locus-tag	class	description
VDIS_RS00025	COG0463	Glycosyl transferase, family 2
VDIS_RS00030	COG0116	Belongs to the methyltransferase superfamily
VDIS_RS00030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VDIS_RS00040	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VDIS_RS00075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VDIS_RS00080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VDIS_RS00090	COG0081	regulation of translation
VDIS_RS00110	COG0457	Tetratricopeptide repeat
VDIS_RS00110	COG0552	protein localization to endoplasmic reticulum
VDIS_RS00130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VDIS_RS00150	COG0405	Gamma-glutamyltransferase
VDIS_RS00160	COG4139	cobalamin transport
VDIS_RS00165	COG1120	ATPase activity
VDIS_RS00170	COG2414	aldehyde ferredoxin oxidoreductase
VDIS_RS00180	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VDIS_RS00180	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VDIS_RS00185	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VDIS_RS00185	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VDIS_RS00215	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
VDIS_RS00230	COG0037	tRNA processing
VDIS_RS00255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VDIS_RS00305	COG0531	amino acid
VDIS_RS00310	COG0531	amino acid
VDIS_RS00345	COG2814	Major facilitator Superfamily
VDIS_RS00400	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
VDIS_RS00415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VDIS_RS00420	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VDIS_RS00425	COG0200	Binds to the 23S rRNA
VDIS_RS00460	COG1028	Short-chain dehydrogenase reductase Sdr
VDIS_RS00490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VDIS_RS00495	COG1363	Peptidase, m42
VDIS_RS00500	COG2252	PERMEase
VDIS_RS00620	COG2226	methyltransferase
VDIS_RS00820	COG0433	COG0433 Predicted ATPase
VDIS_RS00935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VDIS_RS00950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VDIS_RS00960	COG0189	ligase activity
VDIS_RS00965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VDIS_RS00970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VDIS_RS00975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VDIS_RS00980	COG0189	ligase activity
VDIS_RS00990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VDIS_RS00995	COG0436	Aminotransferase
VDIS_RS01000	COG0505	Belongs to the CarA family
VDIS_RS01005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VDIS_RS01010	COG0165	Argininosuccinate lyase
VDIS_RS01030	COG0137	argininosuccinate synthase activity
VDIS_RS01035	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VDIS_RS01045	COG1605	Chorismate mutase
VDIS_RS01045	COG0077	Prephenate dehydratase
VDIS_RS01050	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
VDIS_RS01055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VDIS_RS01060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VDIS_RS01070	COG0083	homoserine kinase activity
VDIS_RS01080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VDIS_RS01090	COG0134	indole-3-glycerol-phosphate synthase activity
VDIS_RS01095	COG0159	tryptophan synthase activity
VDIS_RS01100	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
VDIS_RS01105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VDIS_RS01110	COG0135	phosphoribosylanthranilate isomerase activity
VDIS_RS01115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VDIS_RS01120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VDIS_RS01120	COG0512	Glutamine amidotransferase of anthranilate synthase
VDIS_RS01125	COG0574	Belongs to the PEP-utilizing enzyme family
VDIS_RS01125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VDIS_RS01145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VDIS_RS01150	COG0396	ATPase activity
VDIS_RS01155	COG0719	Fe-S assembly protein
VDIS_RS01160	COG0719	Fe-S assembly protein
VDIS_RS01170	COG2226	methyltransferase
VDIS_RS01195	COG0483	inositol monophosphate 1-phosphatase activity
VDIS_RS01235	COG0318	PFAM AMP-dependent synthetase and ligase
VDIS_RS01245	COG1024	Enoyl-CoA hydratase
VDIS_RS01255	COG0183	Belongs to the thiolase family
VDIS_RS01260	COG1250	3-hydroxyacyl-CoA dehydrogenase
VDIS_RS01270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VDIS_RS01275	COG0028	Belongs to the TPP enzyme family
VDIS_RS01290	COG1960	acyl-CoA dehydrogenase activity
VDIS_RS01325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VDIS_RS01335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VDIS_RS01340	COG0277	FAD linked oxidase domain protein
VDIS_RS01360	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
VDIS_RS01365	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
VDIS_RS01390	COG0019	diaminopimelate decarboxylase activity
VDIS_RS01400	COG2814	Major facilitator Superfamily
VDIS_RS01435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VDIS_RS01455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VDIS_RS01495	COG0237	dephospho-CoA kinase activity
VDIS_RS01500	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
VDIS_RS01510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VDIS_RS01540	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
VDIS_RS01555	COG2062	phosphohistidine phosphatase, SixA
VDIS_RS01565	COG0535	radical SAM domain protein
VDIS_RS01570	COG0535	radical SAM domain protein
VDIS_RS01575	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VDIS_RS01580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VDIS_RS01625	COG2409	Drug exporters of the RND superfamily
VDIS_RS01630	COG1136	(ABC) transporter
VDIS_RS01655	COG1881	PFAM PEBP family protein
VDIS_RS01705	COG0303	'Molybdopterin
VDIS_RS01710	COG0318	PFAM AMP-dependent synthetase and ligase
VDIS_RS01715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VDIS_RS01725	COG0069	glutamate synthase activity
VDIS_RS01785	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
VDIS_RS01795	COG0215	cysteine-tRNA ligase activity
VDIS_RS01810	COG1830	Aldolase
VDIS_RS01840	COG2721	sulfolactate sulfo-lyase activity
VDIS_RS01850	COG2084	Dehydrogenase
VDIS_RS01880	COG1312	Catalyzes the dehydration of D-mannonate
VDIS_RS01905	COG4948	Mandelate Racemase Muconate Lactonizing
VDIS_RS01910	COG1063	alcohol dehydrogenase
VDIS_RS01925	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
VDIS_RS01955	COG1136	(ABC) transporter
VDIS_RS01985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VDIS_RS01990	COG0477	Major facilitator Superfamily
VDIS_RS01995	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
VDIS_RS02000	COG2086	electron transfer activity
VDIS_RS02010	COG0644	oxidoreductase
VDIS_RS02015	COG0535	radical SAM domain protein
VDIS_RS02020	COG1032	radical SAM domain protein
VDIS_RS02115	COG0842	Transport permease protein
VDIS_RS02115	COG1131	(ABC) transporter
VDIS_RS02115	COG1716	ATPase activity
VDIS_RS02135	COG0714	Associated with various cellular activities
VDIS_RS02230	COG0463	Glycosyl transferase, family 2
VDIS_RS02240	COG0438	transferase activity, transferring glycosyl groups
VDIS_RS02260	COG0297	glycogen (starch) synthase activity
VDIS_RS02285	COG0438	transferase activity, transferring glycosyl groups
VDIS_RS02300	COG0438	transferase activity, transferring glycosyl groups
VDIS_RS02360	COG1215	transferase activity, transferring glycosyl groups
VDIS_RS02395	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VDIS_RS02400	COG0157	Belongs to the NadC ModD family
VDIS_RS02415	COG3276	selenocysteine insertion sequence binding
VDIS_RS02430	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VDIS_RS02440	COG2226	methyltransferase
VDIS_RS02540	COG1144	Oxidoreductase
VDIS_RS02545	COG0674	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS02550	COG1013	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS02560	COG0277	FAD linked oxidase domain protein
VDIS_RS02565	COG0277	FAD linked oxidase domain protein
VDIS_RS02585	COG4581	dead DEAH box helicase
VDIS_RS02600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VDIS_RS02605	COG2814	Major facilitator Superfamily
VDIS_RS02620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VDIS_RS02680	COG0124	histidyl-tRNA synthetase
VDIS_RS02710	COG3473	Maleate cis-trans isomerase
VDIS_RS02790	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
VDIS_RS02795	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
VDIS_RS02810	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VDIS_RS02815	COG0477	Major facilitator Superfamily
VDIS_RS02820	COG0151	Belongs to the GarS family
VDIS_RS02825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VDIS_RS02830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VDIS_RS02835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VDIS_RS02840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VDIS_RS02845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VDIS_RS02850	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VDIS_RS02855	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VDIS_RS02865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VDIS_RS02870	COG0602	queuosine metabolic process
VDIS_RS02875	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VDIS_RS02880	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VDIS_RS02885	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VDIS_RS02900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VDIS_RS02905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VDIS_RS02910	COG0140	phosphoribosyl-ATP diphosphatase activity
VDIS_RS02910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VDIS_RS02915	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VDIS_RS02920	COG0107	imidazoleglycerol-phosphate synthase activity
VDIS_RS02925	COG0131	Imidazoleglycerol-phosphate dehydratase
VDIS_RS02930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VDIS_RS02935	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VDIS_RS02940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VDIS_RS02945	COG0477	Major facilitator Superfamily
VDIS_RS02960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VDIS_RS02965	COG0527	aspartate kinase activity
VDIS_RS02995	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VDIS_RS03000	COG0519	Catalyzes the synthesis of GMP from XMP
VDIS_RS03000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VDIS_RS03005	COG0519	Catalyzes the synthesis of GMP from XMP
VDIS_RS03015	COG0402	S-adenosylhomocysteine deaminase activity
VDIS_RS03065	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VDIS_RS03065	COG0517	IMP dehydrogenase activity
VDIS_RS03065	COG0617	tRNA 3'-terminal CCA addition
VDIS_RS03070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VDIS_RS03080	COG0420	3'-5' exonuclease activity
VDIS_RS03085	COG0419	ATPase involved in DNA repair
VDIS_RS03135	COG1131	(ABC) transporter
VDIS_RS03145	COG1185	polyribonucleotide nucleotidyltransferase activity
VDIS_RS03155	COG0023	Translation Initiation Factor
VDIS_RS03165	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VDIS_RS03185	COG1201	RNA secondary structure unwinding
VDIS_RS03220	COG1192	Involved in chromosome partitioning
VDIS_RS03275	COG0477	Major facilitator Superfamily
VDIS_RS03330	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
VDIS_RS03335	COG0077	Prephenate dehydratase
VDIS_RS03335	COG1605	Chorismate mutase
VDIS_RS03345	COG0067	glutamate synthase
VDIS_RS03350	COG0473	3-isopropylmalate dehydrogenase activity
VDIS_RS03360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VDIS_RS03365	COG0028	Belongs to the TPP enzyme family
VDIS_RS03375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VDIS_RS03400	COG0372	Belongs to the citrate synthase family
VDIS_RS03405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VDIS_RS03415	COG0674	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS03420	COG1013	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS03425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VDIS_RS03440	COG0066	3-isopropylmalate dehydratase activity
VDIS_RS03445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VDIS_RS03455	COG0051	transcription antitermination factor activity, RNA binding
VDIS_RS03460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VDIS_RS03480	COG0521	Mo-molybdopterin cofactor biosynthetic process
VDIS_RS03505	COG0495	leucyl-tRNA aminoacylation
VDIS_RS03510	COG0517	IMP dehydrogenase activity
VDIS_RS03510	COG0516	GMP reductase activity
VDIS_RS03525	COG0469	pyruvate kinase activity
VDIS_RS03555	COG0174	glutamine synthetase
VDIS_RS03565	COG3118	belongs to the thioredoxin family
VDIS_RS03585	COG1102	Psort location Cytoplasmic, score
VDIS_RS03600	COG1355	regulation of microtubule-based process
VDIS_RS03605	COG0052	Belongs to the universal ribosomal protein uS2 family
VDIS_RS03610	COG0148	phosphopyruvate hydratase activity
VDIS_RS03625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VDIS_RS03625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VDIS_RS03645	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
VDIS_RS03675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VDIS_RS03685	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VDIS_RS03730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
VDIS_RS03790	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
VDIS_RS03810	COG0537	adenosine 5'-monophosphoramidase activity
VDIS_RS03825	COG0303	'Molybdopterin
VDIS_RS03865	COG0477	Major facilitator Superfamily
VDIS_RS03925	COG1121	(ABC) transporter
VDIS_RS03930	COG0671	phosphoesterase, PA-phosphatase related
VDIS_RS03950	COG2226	methyltransferase
VDIS_RS03960	COG0561	phosphatase activity
VDIS_RS03970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VDIS_RS04000	COG0546	phosphoglycolate phosphatase activity
VDIS_RS04015	COG2078	PFAM AMMECR1 domain protein
VDIS_RS04045	COG0071	Belongs to the small heat shock protein (HSP20) family
VDIS_RS04055	COG2264	protein methyltransferase activity
VDIS_RS04100	COG0644	oxidoreductase
VDIS_RS04105	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
VDIS_RS04110	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VDIS_RS04120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VDIS_RS04125	COG1185	polyribonucleotide nucleotidyltransferase activity
VDIS_RS04130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VDIS_RS04175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VDIS_RS04185	COG1185	polyribonucleotide nucleotidyltransferase activity
VDIS_RS04330	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VDIS_RS04335	COG0746	molybdenum cofactor guanylyltransferase activity
VDIS_RS04345	COG0123	including yeast histone deacetylase and acetoin utilization protein
VDIS_RS04450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VDIS_RS04495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VDIS_RS04505	COG0200	Binds to the 23S rRNA
VDIS_RS04520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VDIS_RS04545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VDIS_RS04560	COG1201	RNA secondary structure unwinding
VDIS_RS04590	COG3842	ATPase activity
VDIS_RS04595	COG0281	malic enzyme
VDIS_RS04605	COG1522	sequence-specific DNA binding
VDIS_RS04610	COG0417	DNA replication proofreading
VDIS_RS04625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VDIS_RS04635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VDIS_RS04650	COG0109	protoheme IX farnesyltransferase activity
VDIS_RS04755	COG1444	tRNA N-acetyltransferase activity
VDIS_RS04765	COG0651	ATP synthesis coupled electron transport
VDIS_RS04770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VDIS_RS04770	COG2111	Na H antiporter
VDIS_RS04775	COG1139	Iron-sulfur cluster binding protein
VDIS_RS04780	COG0709	Synthesizes selenophosphate from selenide and ATP
VDIS_RS04785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VDIS_RS04865	COG2095	MarC family integral membrane protein
VDIS_RS04870	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VDIS_RS04900	COG0531	amino acid
VDIS_RS04905	COG0569	domain protein
VDIS_RS04930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VDIS_RS04940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VDIS_RS04985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VDIS_RS05010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VDIS_RS05010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VDIS_RS05020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VDIS_RS05040	COG0402	S-adenosylhomocysteine deaminase activity
VDIS_RS05060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VDIS_RS05075	COG0433	COG0433 Predicted ATPase
VDIS_RS05085	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
VDIS_RS05090	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VDIS_RS05095	COG1702	phosphate starvation-inducible protein PhoH
VDIS_RS05145	COG0456	acetyltransferase
VDIS_RS05155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VDIS_RS05170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VDIS_RS05220	COG1013	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS05270	COG0586	Pfam SNARE associated Golgi protein
VDIS_RS05395	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VDIS_RS05405	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VDIS_RS05410	COG0045	succinate-CoA ligase (ADP-forming) activity
VDIS_RS05430	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VDIS_RS05435	COG3842	ATPase activity
VDIS_RS05445	COG0540	Belongs to the ATCase OTCase family
VDIS_RS05450	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VDIS_RS05455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VDIS_RS05460	COG0167	dihydroorotate dehydrogenase activity
VDIS_RS05485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VDIS_RS05505	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VDIS_RS05535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VDIS_RS05550	COG0697	spore germination
VDIS_RS05560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VDIS_RS05835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VDIS_RS05840	COG0419	ATPase involved in DNA repair
VDIS_RS05890	COG0459	protein refolding
VDIS_RS05900	COG0456	acetyltransferase
VDIS_RS05905	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
VDIS_RS05910	COG1324	tolerance protein
VDIS_RS05915	COG0667	Aldo Keto reductase
VDIS_RS05920	COG0352	thiamine-phosphate diphosphorylase activity
VDIS_RS05925	COG0668	transmembrane transport
VDIS_RS05930	COG0012	GTP binding
VDIS_RS05935	COG0018	arginyl-trna synthetase
VDIS_RS05945	COG0085	RNA polymerase activity
VDIS_RS05950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VDIS_RS05955	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VDIS_RS05980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VDIS_RS05980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VDIS_RS06010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VDIS_RS06015	COG2814	Major facilitator Superfamily
VDIS_RS06040	COG0667	Aldo Keto reductase
VDIS_RS06085	COG0425	Belongs to the sulfur carrier protein TusA family
VDIS_RS06090	COG1254	Belongs to the acylphosphatase family
VDIS_RS06100	COG0101	tRNA pseudouridine synthase activity
VDIS_RS06110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VDIS_RS06145	COG0149	triose-phosphate isomerase activity
VDIS_RS06155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VDIS_RS06205	COG0517	IMP dehydrogenase activity
VDIS_RS06205	COG0516	GMP reductase activity
VDIS_RS06220	COG0649	NAD binding
VDIS_RS06220	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VDIS_RS06220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VDIS_RS06225	COG0649	NAD binding
VDIS_RS06250	COG1960	acyl-CoA dehydrogenase activity
VDIS_RS06255	COG1960	acyl-CoA dehydrogenase activity
VDIS_RS06260	COG0318	PFAM AMP-dependent synthetase and ligase
VDIS_RS06275	COG1250	3-hydroxyacyl-CoA dehydrogenase
VDIS_RS06290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VDIS_RS06300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VDIS_RS06330	COG2255	four-way junction helicase activity
VDIS_RS06355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VDIS_RS06405	COG0531	amino acid
VDIS_RS06425	COG0084	hydrolase, TatD family'
VDIS_RS06455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VDIS_RS06475	COG1271	oxidase subunit
VDIS_RS06525	COG1546	Belongs to the CinA family
VDIS_RS06525	COG1058	Belongs to the CinA family
VDIS_RS06530	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
VDIS_RS06540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VDIS_RS06570	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VDIS_RS06675	COG1331	Highly conserved protein containing a thioredoxin domain
VDIS_RS06690	COG0114	fumarate hydratase activity
VDIS_RS06695	COG1741	Belongs to the pirin family
VDIS_RS06720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VDIS_RS06735	COG2897	thiosulfate sulfurtransferase activity
VDIS_RS06750	COG0312	modulator of DNA gyrase
VDIS_RS06760	COG0444	Belongs to the ABC transporter superfamily
VDIS_RS06765	COG4608	Belongs to the ABC transporter superfamily
VDIS_RS06770	COG0747	negative chemotaxis
VDIS_RS06775	COG0601	transmembrane transport
VDIS_RS06780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VDIS_RS06795	COG0531	amino acid
VDIS_RS06805	COG0657	acetylesterase activity
VDIS_RS06815	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
VDIS_RS06825	COG0113	porphobilinogen synthase activity
VDIS_RS06830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VDIS_RS06845	COG0489	protein tyrosine kinase activity
VDIS_RS06850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VDIS_RS06890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VDIS_RS06905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VDIS_RS06905	COG0731	radical SAM domain protein
VDIS_RS06945	COG0477	Major facilitator Superfamily
VDIS_RS06950	COG1304	FMN binding
VDIS_RS06960	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VDIS_RS07085	COG1140	nitrate reductase beta subunit
VDIS_RS07090	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
VDIS_RS07095	COG2181	nitrate reductase activity
VDIS_RS07105	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
VDIS_RS07135	COG3189	MarR family transcriptional regulator
VDIS_RS07140	COG3256	nitric oxide reductase
VDIS_RS07155	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VDIS_RS07155	COG0674	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS07160	COG1013	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS07175	COG4948	Mandelate Racemase Muconate Lactonizing
VDIS_RS07185	COG0604	alcohol dehydrogenase
VDIS_RS07190	COG2814	Major facilitator Superfamily
VDIS_RS07200	COG1260	myo-inositol-1-phosphate synthase
VDIS_RS07210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VDIS_RS07215	COG0315	cyclic pyranopterin monophosphate synthase activity
VDIS_RS07225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VDIS_RS07260	COG0017	Asparaginyl-tRNA synthetase
VDIS_RS07305	COG1960	acyl-CoA dehydrogenase activity
VDIS_RS07335	COG2264	protein methyltransferase activity
VDIS_RS07365	COG2271	Major facilitator Superfamily
VDIS_RS07370	COG0584	glycerophosphoryl diester phosphodiesterase
VDIS_RS07375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VDIS_RS07385	COG2267	carboxylic ester hydrolase activity
VDIS_RS07420	COG0644	oxidoreductase
VDIS_RS07425	COG0463	Glycosyl transferase, family 2
VDIS_RS07435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VDIS_RS07455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VDIS_RS07465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VDIS_RS07475	COG1793	dna ligase
VDIS_RS07480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VDIS_RS07505	COG2813	Specifically methylates the guanine in position
VDIS_RS07510	COG0308	aminopeptidase N
VDIS_RS07525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VDIS_RS07530	COG1584	GPR1 FUN34 yaaH family protein
VDIS_RS07535	COG4608	Belongs to the ABC transporter superfamily
VDIS_RS07540	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
VDIS_RS07585	COG0275	rRNA processing
VDIS_RS07600	COG2192	nodulation
VDIS_RS07675	COG1515	deoxyribonuclease V activity
VDIS_RS07690	COG0531	amino acid
VDIS_RS07775	COG2814	Major facilitator Superfamily
VDIS_RS07790	COG2723	6-phospho-beta-galactosidase activity
VDIS_RS07820	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VDIS_RS07820	COG0674	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS07825	COG1013	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS07845	COG1024	Enoyl-CoA hydratase
VDIS_RS07850	COG0277	FAD linked oxidase domain protein
VDIS_RS07865	COG2271	Major facilitator Superfamily
VDIS_RS07890	COG4608	Belongs to the ABC transporter superfamily
VDIS_RS07895	COG0444	Belongs to the ABC transporter superfamily
VDIS_RS07905	COG0601	transmembrane transport
VDIS_RS07915	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VDIS_RS07925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VDIS_RS07930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VDIS_RS07940	COG0436	Aminotransferase
VDIS_RS07970	COG1028	Short-chain dehydrogenase reductase Sdr
VDIS_RS08005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VDIS_RS08020	COG0714	Associated with various cellular activities
VDIS_RS08035	COG1960	acyl-CoA dehydrogenase activity
VDIS_RS08040	COG1960	acyl-CoA dehydrogenase activity
VDIS_RS08045	COG1573	uracil-dna glycosylase
VDIS_RS08055	COG0180	Tryptophanyl-tRNA synthetase
VDIS_RS08065	COG1980	fructose-bisphosphate aldolase activity
VDIS_RS08115	COG4948	Mandelate Racemase Muconate Lactonizing
VDIS_RS08140	COG1012	belongs to the aldehyde dehydrogenase family
VDIS_RS08155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VDIS_RS08170	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VDIS_RS08195	COG1335	isochorismatase
VDIS_RS08255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VDIS_RS08315	COG1401	restriction endodeoxyribonuclease activity
VDIS_RS08390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VDIS_RS08400	COG0430	RNA-3'-phosphate cyclase activity
VDIS_RS08430	COG0477	Major facilitator Superfamily
VDIS_RS08460	COG0142	geranyltranstransferase activity
VDIS_RS08520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VDIS_RS08540	COG0189	ligase activity
VDIS_RS08585	COG0006	proline dipeptidase activity
VDIS_RS08595	COG1078	dGTPase activity
VDIS_RS08605	COG0180	Tryptophanyl-tRNA synthetase
VDIS_RS08620	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VDIS_RS08625	COG0181	hydroxymethylbilane synthase activity
VDIS_RS08645	COG0402	S-adenosylhomocysteine deaminase activity
VDIS_RS08665	COG0039	L-malate dehydrogenase activity
VDIS_RS08670	COG0009	L-threonylcarbamoyladenylate synthase
VDIS_RS08675	COG2151	metal-sulfur cluster biosynthetic enzyme
VDIS_RS08710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VDIS_RS08720	COG0183	Belongs to the thiolase family
VDIS_RS08745	COG1252	NADH dehydrogenase
VDIS_RS08750	COG1136	(ABC) transporter
VDIS_RS08750	COG0577	efflux transmembrane transporter activity
VDIS_RS08755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VDIS_RS08795	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
VDIS_RS08805	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
VDIS_RS08810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
VDIS_RS08825	COG1051	belongs to the nudix hydrolase family
VDIS_RS08830	COG1254	Belongs to the acylphosphatase family
VDIS_RS08860	COG0243	molybdopterin cofactor binding
VDIS_RS08870	COG1574	metal-dependent hydrolase with the TIM-barrel fold
VDIS_RS08900	COG2379	hydroxypyruvate reductase
VDIS_RS08910	COG0531	amino acid
VDIS_RS08935	COG2835	tetraacyldisaccharide 4'-kinase activity
VDIS_RS08960	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VDIS_RS08980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VDIS_RS08985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VDIS_RS09000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VDIS_RS09050	COG0417	DNA replication proofreading
VDIS_RS09060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VDIS_RS09065	COG1695	Transcriptional regulator
VDIS_RS09070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VDIS_RS09085	COG1051	belongs to the nudix hydrolase family
VDIS_RS09085	COG1056	cytidyltransferase-related domain
VDIS_RS09090	COG0372	Belongs to the citrate synthase family
VDIS_RS09115	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VDIS_RS09135	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
VDIS_RS09150	COG0459	protein refolding
VDIS_RS09180	COG0343	queuine tRNA-ribosyltransferase activity
VDIS_RS09200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VDIS_RS09205	COG0717	Belongs to the dCTP deaminase family
VDIS_RS09215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VDIS_RS09240	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VDIS_RS09265	COG0175	sulfate reduction
VDIS_RS09295	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VDIS_RS09300	COG2079	MmgE PrpD family protein
VDIS_RS09305	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VDIS_RS09320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VDIS_RS09335	COG0693	protein deglycase activity
VDIS_RS09355	COG4555	ABC transporter
VDIS_RS09375	COG1429	ligase activity, forming nitrogen-metal bonds
VDIS_RS09380	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
VDIS_RS09385	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VDIS_RS09390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VDIS_RS09415	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
VDIS_RS09465	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VDIS_RS09470	COG1250	3-hydroxyacyl-CoA dehydrogenase
VDIS_RS09480	COG0725	ABC transporter, periplasmic molybdate-binding protein
VDIS_RS09490	COG1116	anion transmembrane transporter activity
VDIS_RS09505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VDIS_RS09510	COG0423	glycine-tRNA ligase activity
VDIS_RS09515	COG0010	Belongs to the arginase family
VDIS_RS09525	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VDIS_RS09535	COG0674	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS09540	COG1013	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS09570	COG0714	Associated with various cellular activities
VDIS_RS09595	COG0318	PFAM AMP-dependent synthetase and ligase
VDIS_RS09600	COG0708	Exodeoxyribonuclease III
VDIS_RS09625	COG1573	uracil-dna glycosylase
VDIS_RS09635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VDIS_RS09645	COG1881	PFAM PEBP family protein
VDIS_RS09650	COG0072	phenylalanine-tRNA ligase activity
VDIS_RS09700	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
VDIS_RS09705	COG0247	lactate metabolic process
VDIS_RS09705	COG2181	nitrate reductase activity
VDIS_RS09730	COG1748	Saccharopine dehydrogenase
VDIS_RS09735	COG0126	phosphoglycerate kinase activity
VDIS_RS09760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VDIS_RS09765	COG1378	Sugar-specific transcriptional regulator TrmB
VDIS_RS09770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VDIS_RS09780	COG0674	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS09805	COG2217	Heavy metal translocating P-type atpase
VDIS_RS09825	COG0395	ABC-type sugar transport system, permease component
VDIS_RS09880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VDIS_RS09900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VDIS_RS09950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VDIS_RS09975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VDIS_RS09980	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VDIS_RS09980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VDIS_RS09985	COG0538	isocitrate dehydrogenase activity
VDIS_RS10005	COG0494	nUDIX hydrolase
VDIS_RS10015	COG1063	alcohol dehydrogenase
VDIS_RS10020	COG0105	UTP biosynthetic process
VDIS_RS10025	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VDIS_RS10030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VDIS_RS10035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VDIS_RS10040	COG0301	tRNA thio-modification
VDIS_RS10080	COG0444	Belongs to the ABC transporter superfamily
VDIS_RS10085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VDIS_RS10090	COG0601	transmembrane transport
VDIS_RS10170	COG2017	converts alpha-aldose to the beta-anomer
VDIS_RS10270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VDIS_RS10290	COG2046	Belongs to the sulfate adenylyltransferase family
VDIS_RS10320	COG2181	nitrate reductase activity
VDIS_RS10345	COG2221	Nitrite and sulphite reductase 4Fe-4S
VDIS_RS10355	COG2920	part of a sulfur-relay system
VDIS_RS10375	COG0656	L-ascorbic acid biosynthetic process
VDIS_RS10410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VDIS_RS10410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VDIS_RS10420	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VDIS_RS10425	COG1085	galactose-1-phosphate uridylyltransferase
VDIS_RS10445	COG0446	pyridine nucleotide-disulphide oxidoreductase
VDIS_RS10455	COG2210	Belongs to the sulfur carrier protein TusA family
VDIS_RS10485	COG0492	ferredoxin-NADP+ reductase activity
VDIS_RS10490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VDIS_RS10530	COG0247	lactate metabolic process
VDIS_RS10535	COG0277	FAD linked oxidase domain protein
VDIS_RS10555	COG2239	Acts as a magnesium transporter
VDIS_RS10610	COG1007	ATP synthesis coupled electron transport
VDIS_RS10660	COG0437	4 iron, 4 sulfur cluster binding
VDIS_RS10670	COG3301	Polysulphide reductase, NrfD
VDIS_RS10710	COG0805	protein transport
VDIS_RS10725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VDIS_RS10735	COG0450	alkyl hydroperoxide reductase
VDIS_RS10785	COG1024	Enoyl-CoA hydratase
VDIS_RS10795	COG2226	methyltransferase
VDIS_RS10810	COG1940	carbohydrate kinase activity
VDIS_RS10830	COG0569	domain protein
VDIS_RS10835	COG0295	cytidine deaminase activity
VDIS_RS10855	COG1394	ATPase activity, coupled to movement of substances
VDIS_RS10860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VDIS_RS10880	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VDIS_RS10885	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
VDIS_RS10900	COG1960	acyl-CoA dehydrogenase activity
VDIS_RS10905	COG0318	PFAM AMP-dependent synthetase and ligase
VDIS_RS10955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VDIS_RS10975	COG0585	pseudouridine synthase activity
VDIS_RS11000	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VDIS_RS11010	COG2860	membrane
VDIS_RS11015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VDIS_RS11025	COG0049	tRNA binding
VDIS_RS11040	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VDIS_RS11045	COG2271	Major facilitator Superfamily
VDIS_RS11055	COG1592	Rubrerythrin
VDIS_RS11060	COG0735	belongs to the Fur family
VDIS_RS11065	COG0183	Belongs to the thiolase family
VDIS_RS11075	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
VDIS_RS11140	COG0037	tRNA processing
VDIS_RS11160	COG1110	DNA topoisomerase II activity
VDIS_RS11190	COG0674	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS11190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VDIS_RS11195	COG1013	pyruvate-flavodoxin oxidoreductase activity
VDIS_RS11205	COG1233	COG1233 Phytoene dehydrogenase and related
VDIS_RS11210	COG0247	lactate metabolic process
VDIS_RS11210	COG2181	nitrate reductase activity
VDIS_RS11215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
VDIS_RS11220	COG2086	electron transfer activity
VDIS_RS11235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VDIS_RS11245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VDIS_RS11250	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
VDIS_RS11255	COG2255	four-way junction helicase activity
VDIS_RS11260	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VDIS_RS11305	COG4555	ABC transporter
VDIS_RS11315	COG0017	Asparaginyl-tRNA synthetase
VDIS_RS11330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VDIS_RS11390	COG0409	Hydrogenase expression formation protein
VDIS_RS11400	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
VDIS_RS11410	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VDIS_RS11415	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
VDIS_RS11435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VDIS_RS11450	COG1063	alcohol dehydrogenase
VDIS_RS11470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
VDIS_RS11475	COG0516	GMP reductase activity
VDIS_RS11475	COG0517	IMP dehydrogenase activity
VDIS_RS11490	COG0494	nUDIX hydrolase
VDIS_RS11495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VDIS_RS11500	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
VDIS_RS11505	COG1047	Peptidyl-prolyl cis-trans
VDIS_RS11520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VDIS_RS11530	COG0504	CTP synthase activity
VDIS_RS11585	COG0084	hydrolase, TatD family'
VDIS_RS11625	COG4948	Mandelate Racemase Muconate Lactonizing
VDIS_RS11665	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
VDIS_RS11685	COG3118	belongs to the thioredoxin family
VDIS_RS11690	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VDIS_RS11705	COG0501	Belongs to the peptidase M48B family
VDIS_RS11740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VDIS_RS11745	COG2222	sugar isomerase
VDIS_RS11755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VDIS_RS11760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VDIS_RS11780	COG2095	MarC family integral membrane protein
VDIS_RS11805	COG0351	phosphomethylpyrimidine kinase
VDIS_RS11840	COG2329	Antibiotic biosynthesis monooxygenase
VDIS_RS11850	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VDIS_RS11860	COG4946	Tricorn protease homolog
VDIS_RS11860	COG1506	peptidase
VDIS_RS11860	COG0823	Involved in the tonB-independent uptake of proteins
VDIS_RS11890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VDIS_RS11895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VDIS_RS11975	COG1064	alcohol dehydrogenase
VDIS_RS11990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VDIS_RS12000	COG1335	isochorismatase
VDIS_RS12010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VDIS_RS12025	COG1028	Short-chain dehydrogenase reductase Sdr
VDIS_RS12030	COG0471	metal ion transport
VDIS_RS12030	COG3273	potassium ion transport
VDIS_RS12050	COG0252	asparaginase activity
VDIS_RS12060	COG3383	formate dehydrogenase (NAD+) activity
VDIS_RS12070	COG3383	formate dehydrogenase (NAD+) activity
VDIS_RS12090	COG0528	UMP kinase activity
VDIS_RS12130	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VDIS_RS12160	COG1960	acyl-CoA dehydrogenase activity
VDIS_RS12180	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VDIS_RS12190	COG2855	membrane
VDIS_RS12205	COG0010	Belongs to the arginase family
VDIS_RS12220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VDIS_RS12235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VDIS_RS12240	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VDIS_RS12245	COG2986	histidine ammonia-lyase
VDIS_RS12250	COG0531	amino acid
VDIS_RS12260	COG0436	Aminotransferase
VDIS_RS12275	COG1228	amidohydrolase
VDIS_RS12340	COG4948	Mandelate Racemase Muconate Lactonizing
VDIS_RS12345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VDIS_RS12350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VDIS_RS12360	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
VDIS_RS12400	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VDIS_RS12430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VDIS_RS12440	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VDIS_RS12440	COG0517	IMP dehydrogenase activity