locus-tag	class	description
Vsou_RS00025	COG0463	Glycosyl transferase, family 2
Vsou_RS00030	COG0116	Belongs to the methyltransferase superfamily
Vsou_RS00030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Vsou_RS00040	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Vsou_RS00070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Vsou_RS00075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vsou_RS00115	COG0457	Tetratricopeptide repeat
Vsou_RS00115	COG0552	protein localization to endoplasmic reticulum
Vsou_RS00135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Vsou_RS00155	COG0405	Gamma-glutamyltransferase
Vsou_RS00165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vsou_RS00170	COG1120	ATPase activity
Vsou_RS00175	COG2414	aldehyde ferredoxin oxidoreductase
Vsou_RS00185	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vsou_RS00185	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vsou_RS00190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vsou_RS00190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Vsou_RS00220	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Vsou_RS00235	COG0037	tRNA processing
Vsou_RS00245	COG0525	valine-tRNA ligase activity
Vsou_RS00260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vsou_RS00315	COG0402	S-adenosylhomocysteine deaminase activity
Vsou_RS00325	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Vsou_RS00330	COG0157	Belongs to the NadC ModD family
Vsou_RS00335	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Vsou_RS00355	COG1454	alcohol dehydrogenase
Vsou_RS00360	COG0022	dehydrogenase e1 component
Vsou_RS00370	COG0022	dehydrogenase e1 component
Vsou_RS00375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Vsou_RS00385	COG0095	Lipoate-protein ligase
Vsou_RS00395	COG0508	dehydrogenase complex catalyzes the overall conversion of
Vsou_RS00430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Vsou_RS00435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Vsou_RS00440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Vsou_RS00445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Vsou_RS00450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Vsou_RS00455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Vsou_RS00460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Vsou_RS00465	COG0151	Belongs to the GarS family
Vsou_RS00470	COG0477	Major facilitator Superfamily
Vsou_RS00475	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Vsou_RS00480	COG0047	phosphoribosylformylglycinamidine synthase activity
Vsou_RS00540	COG0017	Asparaginyl-tRNA synthetase
Vsou_RS00570	COG0778	Nitroreductase
Vsou_RS00570	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Vsou_RS00605	COG4608	Belongs to the ABC transporter superfamily
Vsou_RS00610	COG0444	Belongs to the ABC transporter superfamily
Vsou_RS00615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vsou_RS00620	COG0601	transmembrane transport
Vsou_RS00625	COG4166	transmembrane transport
Vsou_RS00640	COG0596	Alpha beta hydrolase
Vsou_RS00670	COG0430	RNA-3'-phosphate cyclase activity
Vsou_RS00690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Vsou_RS00725	COG2045	Belongs to the ComB family
Vsou_RS00740	COG5564	TIM-barrel signal transduction protein
Vsou_RS00815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Vsou_RS00860	COG1028	Short-chain dehydrogenase reductase Sdr
Vsou_RS00895	COG0412	Dienelactone hydrolase
Vsou_RS00900	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Vsou_RS00915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vsou_RS00960	COG1205	dead DEAH box helicase
Vsou_RS00960	COG1111	helicase
Vsou_RS00970	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Vsou_RS00975	COG2814	Major facilitator Superfamily
Vsou_RS00980	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Vsou_RS00990	COG1012	belongs to the aldehyde dehydrogenase family
Vsou_RS01015	COG4948	Mandelate Racemase Muconate Lactonizing
Vsou_RS01070	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Vsou_RS01090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Vsou_RS01095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Vsou_RS01110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Vsou_RS01170	COG1492	cobalamin metabolic process
Vsou_RS01180	COG0417	DNA replication proofreading
Vsou_RS01190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Vsou_RS01190	COG1213	nucleotidyl transferase
Vsou_RS01200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Vsou_RS01205	COG0426	domain, Protein
Vsou_RS01225	COG1051	belongs to the nudix hydrolase family
Vsou_RS01225	COG1056	cytidyltransferase-related domain
Vsou_RS01230	COG0372	Belongs to the citrate synthase family
Vsou_RS01255	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Vsou_RS01280	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Vsou_RS01295	COG0459	protein refolding
Vsou_RS01305	COG3854	ATPases associated with a variety of cellular activities
Vsou_RS01325	COG0343	queuine tRNA-ribosyltransferase activity
Vsou_RS01345	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vsou_RS01350	COG0717	Belongs to the dCTP deaminase family
Vsou_RS01360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Vsou_RS01380	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Vsou_RS01405	COG0175	sulfate reduction
Vsou_RS01440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Vsou_RS01445	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Vsou_RS01450	COG2079	MmgE PrpD family protein
Vsou_RS01470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Vsou_RS01480	COG0456	acetyltransferase
Vsou_RS01535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vsou_RS01600	COG0395	ABC-type sugar transport system, permease component
Vsou_RS01630	COG2217	Heavy metal translocating P-type atpase
Vsou_RS01655	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS01665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Vsou_RS01670	COG1378	Sugar-specific transcriptional regulator TrmB
Vsou_RS01675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Vsou_RS01700	COG0126	phosphoglycerate kinase activity
Vsou_RS01725	COG0515	serine threonine protein kinase
Vsou_RS01725	COG2815	serine threonine protein kinase
Vsou_RS01730	COG0247	lactate metabolic process
Vsou_RS01730	COG2181	nitrate reductase activity
Vsou_RS01735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Vsou_RS01740	COG2086	electron transfer activity
Vsou_RS01815	COG0714	Associated with various cellular activities
Vsou_RS01835	COG0072	phenylalanine-tRNA ligase activity
Vsou_RS01840	COG1881	PFAM PEBP family protein
Vsou_RS01850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Vsou_RS01860	COG1573	uracil-dna glycosylase
Vsou_RS01885	COG0708	Exodeoxyribonuclease III
Vsou_RS01890	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_RS01915	COG0714	Associated with various cellular activities
Vsou_RS01935	COG2271	Major facilitator Superfamily
Vsou_RS02000	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Vsou_RS02010	COG0243	molybdopterin cofactor binding
Vsou_RS02040	COG1254	Belongs to the acylphosphatase family
Vsou_RS02060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Vsou_RS02065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Vsou_RS02105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vsou_RS02110	COG0577	efflux transmembrane transporter activity
Vsou_RS02115	COG1252	NADH dehydrogenase
Vsou_RS02125	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Vsou_RS02140	COG0183	Belongs to the thiolase family
Vsou_RS02150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Vsou_RS02185	COG2151	metal-sulfur cluster biosynthetic enzyme
Vsou_RS02190	COG0009	L-threonylcarbamoyladenylate synthase
Vsou_RS02195	COG0039	L-malate dehydrogenase activity
Vsou_RS02215	COG0402	S-adenosylhomocysteine deaminase activity
Vsou_RS02250	COG0180	Tryptophanyl-tRNA synthetase
Vsou_RS02310	COG0189	ligase activity
Vsou_RS02340	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_RS02350	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_RS02395	COG0142	geranyltranstransferase activity
Vsou_RS02430	COG1363	Peptidase, m42
Vsou_RS02435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Vsou_RS02445	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Vsou_RS02465	COG1028	Short-chain dehydrogenase reductase Sdr
Vsou_RS02505	COG0200	Binds to the 23S rRNA
Vsou_RS02515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Vsou_RS02530	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Vsou_RS02545	COG0477	Major facilitator Superfamily
Vsou_RS02560	COG0668	transmembrane transport
Vsou_RS02580	COG0371	Dehydrogenase
Vsou_RS02605	COG1144	Oxidoreductase
Vsou_RS02610	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS02615	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS02645	COG0083	homoserine kinase activity
Vsou_RS02660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Vsou_RS02675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vsou_RS02690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Vsou_RS02755	COG0124	histidyl-tRNA synthetase
Vsou_RS02905	COG1331	Highly conserved protein containing a thioredoxin domain
Vsou_RS02920	COG0114	fumarate hydratase activity
Vsou_RS02925	COG1741	Belongs to the pirin family
Vsou_RS02950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vsou_RS02965	COG2897	thiosulfate sulfurtransferase activity
Vsou_RS02980	COG0312	modulator of DNA gyrase
Vsou_RS02990	COG0444	Belongs to the ABC transporter superfamily
Vsou_RS02995	COG4608	Belongs to the ABC transporter superfamily
Vsou_RS03000	COG0747	negative chemotaxis
Vsou_RS03005	COG0601	transmembrane transport
Vsou_RS03010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vsou_RS03025	COG0657	acetylesterase activity
Vsou_RS03035	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Vsou_RS03045	COG0113	porphobilinogen synthase activity
Vsou_RS03050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vsou_RS03065	COG0489	protein tyrosine kinase activity
Vsou_RS03070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Vsou_RS03160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vsou_RS03160	COG0731	radical SAM domain protein
Vsou_RS03195	COG0477	Major facilitator Superfamily
Vsou_RS03200	COG1304	FMN binding
Vsou_RS03210	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Vsou_RS03275	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS03280	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS03290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vsou_RS03300	COG0010	Belongs to the arginase family
Vsou_RS03305	COG0423	glycine-tRNA ligase activity
Vsou_RS03310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Vsou_RS03335	COG0725	ABC transporter, periplasmic molybdate-binding protein
Vsou_RS03340	COG4149	molybdate abc transporter
Vsou_RS03345	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vsou_RS03350	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Vsou_RS03405	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Vsou_RS03430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vsou_RS03435	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Vsou_RS03440	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Vsou_RS03445	COG1429	ligase activity, forming nitrogen-metal bonds
Vsou_RS03465	COG4555	ABC transporter
Vsou_RS03475	COG0477	Major facilitator Superfamily
Vsou_RS03500	COG0584	glycerophosphoryl diester phosphodiesterase
Vsou_RS03505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Vsou_RS03515	COG2267	carboxylic ester hydrolase activity
Vsou_RS03555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Vsou_RS03575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Vsou_RS03595	COG1793	dna ligase
Vsou_RS03600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Vsou_RS03625	COG2813	Specifically methylates the guanine in position
Vsou_RS03650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vsou_RS03655	COG1584	GPR1 FUN34 yaaH family protein
Vsou_RS03660	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Vsou_RS03720	COG1215	transferase activity, transferring glycosyl groups
Vsou_RS03730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vsou_RS03745	COG2192	nodulation
Vsou_RS03750	COG2890	protein-(glutamine-N5) methyltransferase activity
Vsou_RS03830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vsou_RS03830	COG0301	tRNA thio-modification
Vsou_RS03835	COG1515	deoxyribonuclease V activity
Vsou_RS03850	COG0531	amino acid
Vsou_RS03935	COG2723	6-phospho-beta-galactosidase activity
Vsou_RS03955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vsou_RS03955	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS03960	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS03975	COG0517	IMP dehydrogenase activity
Vsou_RS03975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Vsou_RS03980	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_RS03985	COG1960	acyl-CoA dehydrogenase activity
Vsou_RS03990	COG1309	transcriptional regulator
Vsou_RS04000	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_RS04005	COG2267	carboxylic ester hydrolase activity
Vsou_RS04030	COG1024	Enoyl-CoA hydratase
Vsou_RS04035	COG0277	FAD linked oxidase domain protein
Vsou_RS04055	COG1489	DNA binding
Vsou_RS04060	COG0252	asparaginase activity
Vsou_RS04065	COG3383	formate dehydrogenase (NAD+) activity
Vsou_RS04075	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Vsou_RS04080	COG3383	formate dehydrogenase (NAD+) activity
Vsou_RS04135	COG0477	Major facilitator Superfamily
Vsou_RS04165	COG1358	cellular component organization or biogenesis
Vsou_RS04170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Vsou_RS04175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Vsou_RS04180	COG0085	RNA polymerase activity
Vsou_RS04190	COG0018	arginyl-trna synthetase
Vsou_RS04195	COG0012	GTP binding
Vsou_RS04215	COG0667	Aldo Keto reductase
Vsou_RS04220	COG1324	tolerance protein
Vsou_RS04225	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Vsou_RS04230	COG0454	-acetyltransferase
Vsou_RS04230	COG0456	acetyltransferase
Vsou_RS04240	COG0459	protein refolding
Vsou_RS04295	COG0419	ATPase involved in DNA repair
Vsou_RS04440	COG1012	belongs to the aldehyde dehydrogenase family
Vsou_RS04555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vsou_RS04565	COG0697	spore germination
Vsou_RS04580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Vsou_RS04610	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Vsou_RS04655	COG0167	dihydroorotate dehydrogenase activity
Vsou_RS04660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Vsou_RS04660	COG0284	orotidine-5'-phosphate decarboxylase activity
Vsou_RS04665	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Vsou_RS04670	COG0540	Belongs to the ATCase OTCase family
Vsou_RS04680	COG3842	ATPase activity
Vsou_RS04685	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Vsou_RS04705	COG0045	succinate-CoA ligase (ADP-forming) activity
Vsou_RS04710	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Vsou_RS04720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vsou_RS04805	COG0586	Pfam SNARE associated Golgi protein
Vsou_RS04845	COG1136	(ABC) transporter
Vsou_RS04880	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS04955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Vsou_RS04975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vsou_RS04985	COG0456	acetyltransferase
Vsou_RS05020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vsou_RS05030	COG1702	phosphate starvation-inducible protein PhoH
Vsou_RS05035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Vsou_RS05040	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Vsou_RS05065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vsou_RS05105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Vsou_RS05110	COG0612	Peptidase, M16
Vsou_RS05115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vsou_RS05115	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vsou_RS05145	COG0442	prolyl-tRNA aminoacylation
Vsou_RS05195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Vsou_RS05200	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_RS05220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vsou_RS05225	COG0569	domain protein
Vsou_RS05250	COG1492	cobalamin metabolic process
Vsou_RS05260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Vsou_RS05265	COG2095	MarC family integral membrane protein
Vsou_RS05345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Vsou_RS05355	COG1139	Iron-sulfur cluster binding protein
Vsou_RS05365	COG0651	ATP synthesis coupled electron transport
Vsou_RS05375	COG1444	tRNA N-acetyltransferase activity
Vsou_RS05480	COG1612	heme a metabolic process
Vsou_RS05480	COG0109	protoheme IX farnesyltransferase activity
Vsou_RS05495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Vsou_RS05505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Vsou_RS05525	COG1522	sequence-specific DNA binding
Vsou_RS05535	COG0281	malic enzyme
Vsou_RS05570	COG1201	RNA secondary structure unwinding
Vsou_RS05585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Vsou_RS05600	COG0089	rRNA binding
Vsou_RS05610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Vsou_RS05635	COG0200	Binds to the 23S rRNA
Vsou_RS05645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Vsou_RS05700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Vsou_RS05750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vsou_RS05765	COG0516	GMP reductase activity
Vsou_RS05765	COG0517	IMP dehydrogenase activity
Vsou_RS05815	COG0746	molybdenum cofactor guanylyltransferase activity
Vsou_RS05820	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Vsou_RS05860	COG0463	Glycosyl transferase, family 2
Vsou_RS05895	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Vsou_RS05960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Vsou_RS05990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Vsou_RS06040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Vsou_RS06045	COG1185	polyribonucleotide nucleotidyltransferase activity
Vsou_RS06050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Vsou_RS06060	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Vsou_RS06065	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Vsou_RS06070	COG0644	oxidoreductase
Vsou_RS06115	COG2890	protein-(glutamine-N5) methyltransferase activity
Vsou_RS06125	COG0071	Belongs to the small heat shock protein (HSP20) family
Vsou_RS06155	COG2078	PFAM AMMECR1 domain protein
Vsou_RS06170	COG0546	phosphoglycolate phosphatase activity
Vsou_RS06195	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Vsou_RS06200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vsou_RS06220	COG2226	methyltransferase
Vsou_RS06240	COG0671	phosphoesterase, PA-phosphatase related
Vsou_RS06245	COG1121	(ABC) transporter
Vsou_RS06310	COG0477	Major facilitator Superfamily
Vsou_RS06370	COG1058	Belongs to the CinA family
Vsou_RS06370	COG1546	Belongs to the CinA family
Vsou_RS06405	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
Vsou_RS06455	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Vsou_RS06495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vsou_RS06495	COG1648	precorrin-2 dehydrogenase activity
Vsou_RS06500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Vsou_RS06510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Vsou_RS06620	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Vsou_RS06695	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Vsou_RS06840	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Vsou_RS06855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Vsou_RS06855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Vsou_RS06865	COG0148	phosphopyruvate hydratase activity
Vsou_RS06870	COG0052	Belongs to the universal ribosomal protein uS2 family
Vsou_RS06875	COG1355	regulation of microtubule-based process
Vsou_RS06910	COG3118	belongs to the thioredoxin family
Vsou_RS06920	COG0174	glutamine synthetase
Vsou_RS06925	COG0004	ammonium transporteR
Vsou_RS06965	COG0516	GMP reductase activity
Vsou_RS06965	COG0517	IMP dehydrogenase activity
Vsou_RS06970	COG0495	leucyl-tRNA aminoacylation
Vsou_RS07015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Vsou_RS07020	COG0051	transcription antitermination factor activity, RNA binding
Vsou_RS07030	COG0612	Peptidase, M16
Vsou_RS07035	COG0137	argininosuccinate synthase activity
Vsou_RS07050	COG0165	Argininosuccinate lyase
Vsou_RS07055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Vsou_RS07060	COG0505	Belongs to the CarA family
Vsou_RS07065	COG0436	Aminotransferase
Vsou_RS07070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Vsou_RS07080	COG0189	ligase activity
Vsou_RS07085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vsou_RS07090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vsou_RS07095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Vsou_RS07100	COG0189	ligase activity
Vsou_RS07110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Vsou_RS07125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Vsou_RS07160	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Vsou_RS07165	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Vsou_RS07175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Vsou_RS07180	COG0477	Major facilitator Superfamily
Vsou_RS07185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Vsou_RS07195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vsou_RS07195	COG0574	Belongs to the PEP-utilizing enzyme family
Vsou_RS07200	COG0512	Glutamine amidotransferase of anthranilate synthase
Vsou_RS07200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Vsou_RS07205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Vsou_RS07210	COG0135	phosphoribosylanthranilate isomerase activity
Vsou_RS07215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Vsou_RS07220	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Vsou_RS07225	COG0159	tryptophan synthase activity
Vsou_RS07230	COG0134	indole-3-glycerol-phosphate synthase activity
Vsou_RS07240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Vsou_RS07245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Vsou_RS07250	COG0083	homoserine kinase activity
Vsou_RS07260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Vsou_RS07265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Vsou_RS07270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Vsou_RS07275	COG0077	Prephenate dehydratase
Vsou_RS07275	COG1605	Chorismate mutase
Vsou_RS07290	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Vsou_RS07305	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Vsou_RS07310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Vsou_RS07310	COG0519	Catalyzes the synthesis of GMP from XMP
Vsou_RS07325	COG0402	S-adenosylhomocysteine deaminase activity
Vsou_RS07370	COG0617	tRNA 3'-terminal CCA addition
Vsou_RS07370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Vsou_RS07370	COG0517	IMP dehydrogenase activity
Vsou_RS07375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Vsou_RS07385	COG0420	3'-5' exonuclease activity
Vsou_RS07390	COG0419	ATPase involved in DNA repair
Vsou_RS07405	COG0475	glutathione-regulated potassium exporter activity
Vsou_RS07450	COG1131	(ABC) transporter
Vsou_RS07460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Vsou_RS07460	COG0539	negative regulation of cytoplasmic translation
Vsou_RS07470	COG0023	Translation Initiation Factor
Vsou_RS07480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Vsou_RS07495	COG1201	RNA secondary structure unwinding
Vsou_RS07540	COG1192	Involved in chromosome partitioning
Vsou_RS07570	COG1136	(ABC) transporter
Vsou_RS07640	COG2814	Major facilitator Superfamily
Vsou_RS07655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Vsou_RS07675	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Vsou_RS07705	COG0277	FAD linked oxidase domain protein
Vsou_RS07710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Vsou_RS07720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vsou_RS07750	COG1960	acyl-CoA dehydrogenase activity
Vsou_RS07765	COG0028	Belongs to the TPP enzyme family
Vsou_RS07770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vsou_RS07780	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vsou_RS07785	COG0183	Belongs to the thiolase family
Vsou_RS07795	COG1024	Enoyl-CoA hydratase
Vsou_RS07810	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_RS07830	COG0483	inositol monophosphate 1-phosphatase activity
Vsou_RS07940	COG1618	nucleotide phosphatase activity, acting on free nucleotides
Vsou_RS07955	COG0719	Fe-S assembly protein
Vsou_RS07960	COG0719	Fe-S assembly protein
Vsou_RS07965	COG0719	Fe-S assembly protein
Vsou_RS07980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Vsou_RS07985	COG0527	aspartate kinase activity
Vsou_RS07990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vsou_RS08005	COG0066	3-isopropylmalate dehydratase activity
Vsou_RS08015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Vsou_RS08025	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS08030	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS08040	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vsou_RS08050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vsou_RS08055	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Vsou_RS08065	COG0028	Belongs to the TPP enzyme family
Vsou_RS08075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vsou_RS08085	COG0473	3-isopropylmalate dehydrogenase activity
Vsou_RS08090	COG0067	glutamate synthase
Vsou_RS08095	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Vsou_RS08095	COG0069	glutamate synthase activity
Vsou_RS08100	COG0077	Prephenate dehydratase
Vsou_RS08100	COG1605	Chorismate mutase
Vsou_RS08105	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
Vsou_RS08135	COG0477	Major facilitator Superfamily
Vsou_RS08140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Vsou_RS08150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vsou_RS08195	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
Vsou_RS08205	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Vsou_RS08230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vsou_RS08230	COG0574	Belongs to the PEP-utilizing enzyme family
Vsou_RS08235	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Vsou_RS08260	COG0535	radical SAM domain protein
Vsou_RS08265	COG0535	radical SAM domain protein
Vsou_RS08295	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Vsou_RS08315	COG2409	Drug exporters of the RND superfamily
Vsou_RS08320	COG1136	(ABC) transporter
Vsou_RS08330	COG0302	gtp cyclohydrolase
Vsou_RS08340	COG0129	dihydroxy-acid dehydratase activity
Vsou_RS08345	COG1881	PFAM PEBP family protein
Vsou_RS08405	COG0303	'Molybdopterin
Vsou_RS08425	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_RS08430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vsou_RS08435	COG0069	glutamate synthase activity
Vsou_RS08440	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Vsou_RS08480	COG0255	Belongs to the universal ribosomal protein uL29 family
Vsou_RS08495	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Vsou_RS08505	COG0215	cysteine-tRNA ligase activity
Vsou_RS08520	COG1830	Aldolase
Vsou_RS08545	COG2721	sulfolactate sulfo-lyase activity
Vsou_RS08570	COG2084	Dehydrogenase
Vsou_RS08585	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vsou_RS08605	COG3386	PFAM SMP-30 Gluconolaconase
Vsou_RS08625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vsou_RS08735	COG0436	Aminotransferase
Vsou_RS08755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Vsou_RS08835	COG2192	nodulation
Vsou_RS08850	COG1216	Glycosyl transferase, family 2
Vsou_RS08850	COG0463	Glycosyl transferase, family 2
Vsou_RS08860	COG0438	transferase activity, transferring glycosyl groups
Vsou_RS08890	COG0438	transferase activity, transferring glycosyl groups
Vsou_RS08895	COG0438	transferase activity, transferring glycosyl groups
Vsou_RS08900	COG0438	transferase activity, transferring glycosyl groups
Vsou_RS08930	COG0438	transferase activity, transferring glycosyl groups
Vsou_RS08940	COG0297	glycogen (starch) synthase activity
Vsou_RS08945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vsou_RS09040	COG0714	Associated with various cellular activities
Vsou_RS09060	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Vsou_RS09080	COG3273	potassium ion transport
Vsou_RS09080	COG0471	metal ion transport
Vsou_RS09085	COG1028	Short-chain dehydrogenase reductase Sdr
Vsou_RS09115	COG3118	belongs to the thioredoxin family
Vsou_RS09120	COG1335	isochorismatase
Vsou_RS09130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Vsou_RS09145	COG2226	methyltransferase
Vsou_RS09160	COG1028	Short-chain dehydrogenase reductase Sdr
Vsou_RS09185	COG0425	Belongs to the sulfur carrier protein TusA family
Vsou_RS09235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Vsou_RS09250	COG0714	Associated with various cellular activities
Vsou_RS09265	COG1960	acyl-CoA dehydrogenase activity
Vsou_RS09270	COG1960	acyl-CoA dehydrogenase activity
Vsou_RS09275	COG1573	uracil-dna glycosylase
Vsou_RS09295	COG1980	fructose-bisphosphate aldolase activity
Vsou_RS09410	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Vsou_RS09415	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Vsou_RS09425	COG0149	triose-phosphate isomerase activity
Vsou_RS09480	COG0101	tRNA pseudouridine synthase activity
Vsou_RS09490	COG1254	Belongs to the acylphosphatase family
Vsou_RS09540	COG0667	Aldo Keto reductase
Vsou_RS09565	COG2814	Major facilitator Superfamily
Vsou_RS09595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Vsou_RS09595	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Vsou_RS09605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Vsou_RS09615	COG1028	Short-chain dehydrogenase reductase Sdr
Vsou_RS09620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Vsou_RS09625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Vsou_RS09625	COG1754	DNA topoisomerase type I activity
Vsou_RS09650	COG1960	acyl-CoA dehydrogenase activity
Vsou_RS09675	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Vsou_RS09695	COG2855	membrane
Vsou_RS09710	COG0010	Belongs to the arginase family
Vsou_RS09760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Vsou_RS09775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Vsou_RS09780	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Vsou_RS09785	COG2986	histidine ammonia-lyase
Vsou_RS09790	COG0436	Aminotransferase
Vsou_RS09795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Vsou_RS09800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Vsou_RS09810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Vsou_RS09825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Vsou_RS09830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Vsou_RS09835	COG0140	phosphoribosyl-ATP diphosphatase activity
Vsou_RS09840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Vsou_RS09845	COG0107	imidazoleglycerol-phosphate synthase activity
Vsou_RS09850	COG0131	Imidazoleglycerol-phosphate dehydratase
Vsou_RS09855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Vsou_RS09860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Vsou_RS09865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vsou_RS09890	COG0585	pseudouridine synthase activity
Vsou_RS09965	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Vsou_RS09975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Vsou_RS09985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vsou_RS09985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vsou_RS09995	COG0315	cyclic pyranopterin monophosphate synthase activity
Vsou_RS10000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Vsou_RS10010	COG1260	myo-inositol-1-phosphate synthase
Vsou_RS10020	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Vsou_RS10025	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS10030	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vsou_RS10030	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS10075	COG3189	MarR family transcriptional regulator
Vsou_RS10095	COG1720	tRNA m6t6A37 methyltransferase activity
Vsou_RS10130	COG2181	nitrate reductase activity
Vsou_RS10135	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Vsou_RS10140	COG1140	nitrate reductase beta subunit
Vsou_RS10180	COG2379	hydroxypyruvate reductase
Vsou_RS10235	COG0528	UMP kinase activity
Vsou_RS10245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Vsou_RS10265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vsou_RS10325	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_RS10330	COG1960	acyl-CoA dehydrogenase activity
Vsou_RS10340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Vsou_RS10340	COG3266	domain, Protein
Vsou_RS10355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Vsou_RS10360	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Vsou_RS10365	COG1047	Peptidyl-prolyl cis-trans
Vsou_RS10380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vsou_RS10390	COG0504	CTP synthase activity
Vsou_RS10445	COG0084	hydrolase, TatD family'
Vsou_RS10475	COG0189	ligase activity
Vsou_RS10505	COG1979	alcohol dehydrogenase
Vsou_RS10515	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Vsou_RS10570	COG3118	belongs to the thioredoxin family
Vsou_RS10575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Vsou_RS10590	COG0501	Belongs to the peptidase M48B family
Vsou_RS10630	COG1372	Participates in initiation and elongation during chromosome replication
Vsou_RS10630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Vsou_RS10640	COG2222	sugar isomerase
Vsou_RS10650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Vsou_RS10675	COG2095	MarC family integral membrane protein
Vsou_RS10710	COG0351	phosphomethylpyrimidine kinase
Vsou_RS10760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Vsou_RS10770	COG4946	Tricorn protease homolog
Vsou_RS10770	COG1506	peptidase
Vsou_RS10770	COG0823	Involved in the tonB-independent uptake of proteins
Vsou_RS10790	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Vsou_RS10795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vsou_RS10815	COG1007	ATP synthesis coupled electron transport
Vsou_RS10865	COG0437	4 iron, 4 sulfur cluster binding
Vsou_RS10870	COG0243	molybdopterin cofactor binding
Vsou_RS10875	COG3301	Polysulphide reductase, NrfD
Vsou_RS10930	COG0805	protein transport
Vsou_RS10945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Vsou_RS10955	COG0450	alkyl hydroperoxide reductase
Vsou_RS11005	COG1024	Enoyl-CoA hydratase
Vsou_RS11010	COG2414	aldehyde ferredoxin oxidoreductase
Vsou_RS11030	COG1940	carbohydrate kinase activity
Vsou_RS11080	COG1110	DNA topoisomerase II activity
Vsou_RS11110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vsou_RS11110	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS11115	COG1013	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS11125	COG1233	COG1233 Phytoene dehydrogenase and related
Vsou_RS11130	COG2181	nitrate reductase activity
Vsou_RS11130	COG0247	lactate metabolic process
Vsou_RS11135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Vsou_RS11140	COG2086	electron transfer activity
Vsou_RS11155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Vsou_RS11165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Vsou_RS11170	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Vsou_RS11175	COG2255	four-way junction helicase activity
Vsou_RS11180	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Vsou_RS11215	COG4555	ABC transporter
Vsou_RS11225	COG0017	Asparaginyl-tRNA synthetase
Vsou_RS11235	COG2814	Major facilitator Superfamily
Vsou_RS11240	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Vsou_RS11255	COG1063	alcohol dehydrogenase
Vsou_RS11275	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Vsou_RS11280	COG0516	GMP reductase activity
Vsou_RS11280	COG0517	IMP dehydrogenase activity
Vsou_RS11310	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Vsou_RS11490	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Vsou_RS11495	COG0183	Belongs to the thiolase family
Vsou_RS11500	COG0735	belongs to the Fur family
Vsou_RS11505	COG1592	Rubrerythrin
Vsou_RS11515	COG2271	Major facilitator Superfamily
Vsou_RS11520	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Vsou_RS11545	COG0049	tRNA binding
Vsou_RS11555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vsou_RS11565	COG2860	membrane
Vsou_RS11575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Vsou_RS11595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Vsou_RS11605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Vsou_RS11610	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Vsou_RS11615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vsou_RS11620	COG1228	amidohydrolase
Vsou_RS11675	COG0516	GMP reductase activity
Vsou_RS11675	COG0517	IMP dehydrogenase activity
Vsou_RS11700	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Vsou_RS11720	COG0516	GMP reductase activity
Vsou_RS11720	COG0517	IMP dehydrogenase activity
Vsou_RS11735	COG0649	NAD binding
Vsou_RS11735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vsou_RS11735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Vsou_RS11740	COG0649	NAD binding
Vsou_RS11790	COG1960	acyl-CoA dehydrogenase activity
Vsou_RS11795	COG1960	acyl-CoA dehydrogenase activity
Vsou_RS11800	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_RS11815	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vsou_RS11830	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Vsou_RS11840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Vsou_RS11870	COG3829	transcription factor binding
Vsou_RS11895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Vsou_RS11945	COG1960	acyl-CoA dehydrogenase activity
Vsou_RS12005	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Vsou_RS12010	COG2226	methyltransferase
Vsou_RS12110	COG0531	amino acid
Vsou_RS12135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Vsou_RS12155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Vsou_RS12175	COG1271	oxidase subunit
Vsou_RS12180	COG0446	pyridine nucleotide-disulphide oxidoreductase
Vsou_RS12220	COG1546	Belongs to the CinA family
Vsou_RS12220	COG1058	Belongs to the CinA family
Vsou_RS12235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vsou_RS12250	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Vsou_RS12255	COG2086	electron transfer activity
Vsou_RS12265	COG0644	oxidoreductase
Vsou_RS12270	COG0535	radical SAM domain protein
Vsou_RS12275	COG1032	radical SAM domain protein
Vsou_RS12295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Vsou_RS12385	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
Vsou_RS12420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Vsou_RS12425	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Vsou_RS12430	COG4948	Mandelate Racemase Muconate Lactonizing
Vsou_RS12455	COG0318	PFAM AMP-dependent synthetase and ligase
Vsou_RS12480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Vsou_RS12485	COG0477	Major facilitator Superfamily
Vsou_RS12490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Vsou_RS12555	COG0277	FAD linked oxidase domain protein
Vsou_RS12560	COG0247	lactate metabolic process
Vsou_RS12575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Vsou_RS12580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Vsou_RS12585	COG0492	ferredoxin-NADP+ reductase activity
Vsou_RS12590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Vsou_RS12595	COG0531	amino acid
Vsou_RS12605	COG2210	Belongs to the sulfur carrier protein TusA family
Vsou_RS12615	COG0446	pyridine nucleotide-disulphide oxidoreductase
Vsou_RS12635	COG1085	galactose-1-phosphate uridylyltransferase
Vsou_RS12655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Vsou_RS12655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Vsou_RS12695	COG0656	L-ascorbic acid biosynthetic process
Vsou_RS12715	COG2920	part of a sulfur-relay system
Vsou_RS12725	COG2221	Nitrite and sulphite reductase 4Fe-4S
Vsou_RS12730	COG2221	Nitrite and sulphite reductase 4Fe-4S
Vsou_RS12780	COG2046	Belongs to the sulfate adenylyltransferase family
Vsou_RS12800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vsou_RS12920	COG0601	transmembrane transport
Vsou_RS12925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vsou_RS12930	COG0444	Belongs to the ABC transporter superfamily
Vsou_RS12935	COG4608	Belongs to the ABC transporter superfamily
Vsou_RS12970	COG0301	tRNA thio-modification
Vsou_RS12975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vsou_RS12980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Vsou_RS12985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Vsou_RS12990	COG0105	UTP biosynthetic process
Vsou_RS12995	COG1063	alcohol dehydrogenase
Vsou_RS13005	COG0494	nUDIX hydrolase
Vsou_RS13010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vsou_RS13025	COG0538	isocitrate dehydrogenase activity
Vsou_RS13030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vsou_RS13030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Vsou_RS13045	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Vsou_RS13050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Vsou_RS13060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Vsou_RS13085	COG3276	selenocysteine insertion sequence binding
Vsou_RS13095	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Vsou_RS13095	COG0674	pyruvate-flavodoxin oxidoreductase activity
Vsou_RS13100	COG1063	alcohol dehydrogenase
Vsou_RS13105	COG4948	Mandelate Racemase Muconate Lactonizing
Vsou_RS13115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Vsou_RS13120	COG0805	protein transport
Vsou_RS13140	COG1653	transport
Vsou_RS13150	COG1129	ABC transporter
Vsou_RS13160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Vsou_RS13170	COG2414	aldehyde ferredoxin oxidoreductase
Vsou_RS13175	COG4948	Mandelate Racemase Muconate Lactonizing
Vsou_RS13185	COG0028	Belongs to the TPP enzyme family
Vsou_RS13195	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Vsou_RS13205	COG0277	FAD linked oxidase domain protein
Vsou_RS13210	COG2814	Major facilitator Superfamily