locus-tag	class	description
AKJ08_RS00005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKJ08_RS00020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKJ08_RS00025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKJ08_RS00030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKJ08_RS00045	COG0483	inositol monophosphate 1-phosphatase activity
AKJ08_RS00050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKJ08_RS00055	COG1666	GTP binding
AKJ08_RS00060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKJ08_RS00075	COG2373	Large extracellular alpha-helical protein
AKJ08_RS00080	COG2373	Large extracellular alpha-helical protein
AKJ08_RS00100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AKJ08_RS00125	COG0297	glycogen (starch) synthase activity
AKJ08_RS00140	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKJ08_RS00145	COG0047	phosphoribosylformylglycinamidine synthase activity
AKJ08_RS00150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKJ08_RS00160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKJ08_RS00190	COG2801	Transposase and inactivated derivatives
AKJ08_RS00220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AKJ08_RS00230	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AKJ08_RS00245	COG0713	ATP synthesis coupled electron transport
AKJ08_RS00250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKJ08_RS00270	COG2204	response regulator
AKJ08_RS00275	COG4191	Histidine kinase
AKJ08_RS00280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKJ08_RS00290	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKJ08_RS00320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AKJ08_RS00340	COG0590	tRNA wobble adenosine to inosine editing
AKJ08_RS00360	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKJ08_RS00365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKJ08_RS00380	COG1013	pyruvate-flavodoxin oxidoreductase activity
AKJ08_RS00385	COG0674	pyruvate-flavodoxin oxidoreductase activity
AKJ08_RS00385	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AKJ08_RS00415	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AKJ08_RS00420	COG1074	ATP-dependent DNA helicase activity
AKJ08_RS00470	COG0545	Peptidyl-prolyl cis-trans isomerase
AKJ08_RS00485	COG1012	belongs to the aldehyde dehydrogenase family
AKJ08_RS00490	COG0463	Glycosyl transferase, family 2
AKJ08_RS00495	COG1368	sulfuric ester hydrolase activity
AKJ08_RS00505	COG1012	belongs to the aldehyde dehydrogenase family
AKJ08_RS00550	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AKJ08_RS00555	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AKJ08_RS00580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKJ08_RS00625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKJ08_RS00630	COG0390	transport system, permease component
AKJ08_RS00635	COG1129	ABC transporter
AKJ08_RS00650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKJ08_RS00665	COG1703	isobutyryl-CoA mutase activity
AKJ08_RS00670	COG2205	protein histidine kinase activity
AKJ08_RS00675	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AKJ08_RS00690	COG0439	Biotin carboxylase
AKJ08_RS00695	COG0511	ligase activity, forming carbon-carbon bonds
AKJ08_RS00745	COG0564	pseudouridine synthase activity
AKJ08_RS00750	COG0617	tRNA 3'-terminal CCA addition
AKJ08_RS00760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKJ08_RS00765	COG0473	3-isopropylmalate dehydrogenase activity
AKJ08_RS00770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKJ08_RS00805	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKJ08_RS00815	COG5520	Belongs to the glycosyl hydrolase 30 family
AKJ08_RS00815	COG4447	cellulose binding
AKJ08_RS00815	COG3291	Pkd domain containing protein
AKJ08_RS00825	COG0484	heat shock protein binding
AKJ08_RS00830	COG0443	Heat shock 70 kDa protein
AKJ08_RS00850	COG0237	dephospho-CoA kinase activity
AKJ08_RS00855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AKJ08_RS00915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKJ08_RS00935	COG0484	heat shock protein binding
AKJ08_RS00940	COG2385	sporulation resulting in formation of a cellular spore
AKJ08_RS00960	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKJ08_RS00980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AKJ08_RS01020	COG1138	Cytochrome C-type biogenesis protein
AKJ08_RS01025	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AKJ08_RS01030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKJ08_RS01040	COG1131	(ABC) transporter
AKJ08_RS01045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKJ08_RS01060	COG2226	methyltransferase
AKJ08_RS01065	COG0163	prenyltransferase activity
AKJ08_RS01075	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AKJ08_RS01080	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AKJ08_RS01090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AKJ08_RS01095	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AKJ08_RS01100	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AKJ08_RS01115	COG0438	transferase activity, transferring glycosyl groups
AKJ08_RS01130	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKJ08_RS01130	COG2755	lipolytic protein G-D-S-L family
AKJ08_RS01190	COG0318	PFAM AMP-dependent synthetase and ligase
AKJ08_RS01195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKJ08_RS01200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKJ08_RS01230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKJ08_RS01235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AKJ08_RS01240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AKJ08_RS01275	COG0285	dihydrofolate synthase activity
AKJ08_RS01290	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AKJ08_RS01295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKJ08_RS01305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKJ08_RS01310	COG1862	Preprotein translocase
AKJ08_RS01315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKJ08_RS01320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKJ08_RS01340	COG2259	Doxx family
AKJ08_RS01355	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AKJ08_RS01355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AKJ08_RS01360	COG3795	YCII-related domain
AKJ08_RS01370	COG4941	Belongs to the sigma-70 factor family
AKJ08_RS01380	COG3384	dioxygenase
AKJ08_RS01405	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AKJ08_RS01410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AKJ08_RS01425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKJ08_RS01430	COG1597	lipid kinase activity
AKJ08_RS01475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKJ08_RS01480	COG0352	thiamine-phosphate diphosphorylase activity
AKJ08_RS01485	COG2022	thiamine diphosphate biosynthetic process
AKJ08_RS01505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKJ08_RS01510	COG0456	acetyltransferase
AKJ08_RS01515	COG0156	8-amino-7-oxononanoate synthase activity
AKJ08_RS01525	COG2937	Belongs to the GPAT DAPAT family
AKJ08_RS01530	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS01535	COG5002	protein histidine kinase activity
AKJ08_RS01555	COG0456	acetyltransferase
AKJ08_RS01560	COG0167	dihydroorotate dehydrogenase activity
AKJ08_RS01575	COG0602	queuosine metabolic process
AKJ08_RS01595	COG1381	Involved in DNA repair and RecF pathway recombination
AKJ08_RS01600	COG0300	oxidoreductase activity
AKJ08_RS01605	COG0277	FAD linked oxidase domain protein
AKJ08_RS01620	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_RS01630	COG0552	protein localization to endoplasmic reticulum
AKJ08_RS01635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AKJ08_RS01655	COG2223	nitrite transmembrane transporter activity
AKJ08_RS01685	COG1610	YqeY-like protein
AKJ08_RS01705	COG1959	2 iron, 2 sulfur cluster binding
AKJ08_RS01705	COG1295	ribonuclease BN
AKJ08_RS01710	COG1530	ribonuclease E activity
AKJ08_RS01740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKJ08_RS01750	COG1408	metallophosphoesterase
AKJ08_RS01755	COG0110	maltose O-acetyltransferase activity
AKJ08_RS01765	COG0577	efflux transmembrane transporter activity
AKJ08_RS01765	COG1136	(ABC) transporter
AKJ08_RS01770	COG0577	efflux transmembrane transporter activity
AKJ08_RS01770	COG1136	(ABC) transporter
AKJ08_RS01775	COG0494	nUDIX hydrolase
AKJ08_RS01805	COG0300	oxidoreductase activity
AKJ08_RS01815	COG0714	Associated with various cellular activities
AKJ08_RS01860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKJ08_RS01895	COG0585	pseudouridine synthase activity
AKJ08_RS01910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKJ08_RS01910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKJ08_RS01915	COG2226	methyltransferase
AKJ08_RS01920	COG0252	asparaginase activity
AKJ08_RS01950	COG2890	protein-(glutamine-N5) methyltransferase activity
AKJ08_RS01970	COG0779	Required for maturation of 30S ribosomal subunits
AKJ08_RS01975	COG0195	Participates in both transcription termination and antitermination
AKJ08_RS01975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKJ08_RS02000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKJ08_RS02005	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKJ08_RS02010	COG1185	polyribonucleotide nucleotidyltransferase activity
AKJ08_RS02020	COG5492	domain, Protein
AKJ08_RS02020	COG4932	domain protein
AKJ08_RS02060	COG0308	aminopeptidase N
AKJ08_RS02065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AKJ08_RS02075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AKJ08_RS02085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKJ08_RS02100	COG1757	Na H antiporter
AKJ08_RS02115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKJ08_RS02120	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS02135	COG2078	PFAM AMMECR1 domain protein
AKJ08_RS02135	COG3885	ferrous iron binding
AKJ08_RS02165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKJ08_RS02170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKJ08_RS02190	COG0066	3-isopropylmalate dehydratase activity
AKJ08_RS02195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKJ08_RS02215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKJ08_RS02230	COG1012	belongs to the aldehyde dehydrogenase family
AKJ08_RS02235	COG1024	Enoyl-CoA hydratase
AKJ08_RS02245	COG1764	response to oxidative stress
AKJ08_RS02275	COG1024	Enoyl-CoA hydratase
AKJ08_RS02280	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKJ08_RS02380	COG1899	peptidyl-lysine modification to peptidyl-hypusine
AKJ08_RS02395	COG2198	Histidine kinase
AKJ08_RS02395	COG0784	Response regulator, receiver
AKJ08_RS02395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKJ08_RS02395	COG2205	protein histidine kinase activity
AKJ08_RS02405	COG0714	Associated with various cellular activities
AKJ08_RS02410	COG1305	Transglutaminase-like
AKJ08_RS02415	COG0488	(ABC) transporter
AKJ08_RS02430	COG0416	fatty acid biosynthetic process
AKJ08_RS02445	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AKJ08_RS02450	COG2096	Adenosyltransferase
AKJ08_RS02465	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKJ08_RS02470	COG1078	dGTPase activity
AKJ08_RS02475	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKJ08_RS02490	COG4191	Histidine kinase
AKJ08_RS02510	COG2885	chlorophyll binding
AKJ08_RS02515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKJ08_RS02520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKJ08_RS02530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKJ08_RS02545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKJ08_RS02570	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AKJ08_RS02580	COG0309	Hydrogenase expression formation protein (HypE)
AKJ08_RS02585	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AKJ08_RS02595	COG0298	carbon dioxide binding
AKJ08_RS02600	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AKJ08_RS02605	COG0375	protein maturation
AKJ08_RS02650	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS02655	COG5002	protein histidine kinase activity
AKJ08_RS02675	COG2719	SpoVR family
AKJ08_RS02680	COG2718	Belongs to the UPF0229 family
AKJ08_RS02685	COG2766	serine protein kinase
AKJ08_RS02695	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKJ08_RS02705	COG0432	Pfam Uncharacterised protein family UPF0047
AKJ08_RS02725	COG1192	Involved in chromosome partitioning
AKJ08_RS02730	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AKJ08_RS02755	COG1999	signal sequence binding
AKJ08_RS02760	COG0515	serine threonine protein kinase
AKJ08_RS02760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKJ08_RS02765	COG2146	nitrite reductase [NAD(P)H] activity
AKJ08_RS02765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKJ08_RS02785	COG1215	transferase activity, transferring glycosyl groups
AKJ08_RS02800	COG0584	glycerophosphoryl diester phosphodiesterase
AKJ08_RS02815	COG0693	protein deglycase activity
AKJ08_RS02835	COG0189	ligase activity
AKJ08_RS02845	COG0793	Belongs to the peptidase S41A family
AKJ08_RS02850	COG0189	ligase activity
AKJ08_RS02865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKJ08_RS02875	COG0584	glycerophosphoryl diester phosphodiesterase
AKJ08_RS02915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKJ08_RS02950	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKJ08_RS02955	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKJ08_RS02960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AKJ08_RS02995	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKJ08_RS03000	COG0740	serine-type endopeptidase activity
AKJ08_RS03035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKJ08_RS03045	COG3387	PFAM Glycoside hydrolase 15-related
AKJ08_RS03055	COG4948	Mandelate Racemase Muconate Lactonizing
AKJ08_RS03060	COG0028	Belongs to the TPP enzyme family
AKJ08_RS03065	COG0247	lactate metabolic process
AKJ08_RS03065	COG0277	FAD linked oxidase domain protein
AKJ08_RS03105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKJ08_RS03105	COG1845	cytochrome c oxidase, subunit III
AKJ08_RS03110	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKJ08_RS03140	COG0437	4 iron, 4 sulfur cluster binding
AKJ08_RS03145	COG0243	molybdopterin cofactor binding
AKJ08_RS03160	COG1796	DNA polymerase
AKJ08_RS03160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKJ08_RS03170	COG0567	Dehydrogenase, E1 component
AKJ08_RS03175	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKJ08_RS03195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKJ08_RS03200	COG0408	coproporphyrinogen oxidase activity
AKJ08_RS03205	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKJ08_RS03225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKJ08_RS03230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKJ08_RS03235	COG0497	DNA recombination
AKJ08_RS03245	COG0739	heme binding
AKJ08_RS03250	COG0653	protein targeting
AKJ08_RS03255	COG0052	Belongs to the universal ribosomal protein uS2 family
AKJ08_RS03260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKJ08_RS03265	COG0528	UMP kinase activity
AKJ08_RS03270	COG0233	cytoplasmic translational termination
AKJ08_RS03300	COG0009	L-threonylcarbamoyladenylate synthase
AKJ08_RS03335	COG0658	competence protein
AKJ08_RS03335	COG2333	competence protein COMEC
AKJ08_RS03340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AKJ08_RS03350	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AKJ08_RS03355	COG0295	cytidine deaminase activity
AKJ08_RS03365	COG0196	riboflavin kinase activity
AKJ08_RS03370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AKJ08_RS03380	COG1459	type II secretion system
AKJ08_RS03385	COG3852	Histidine kinase
AKJ08_RS03435	COG4968	Prepilin-type N-terminal cleavage methylation domain
AKJ08_RS03440	COG1131	(ABC) transporter
AKJ08_RS03445	COG3119	arylsulfatase activity
AKJ08_RS03450	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKJ08_RS03455	COG4191	Histidine kinase
AKJ08_RS03505	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKJ08_RS03515	COG0439	Biotin carboxylase
AKJ08_RS03575	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKJ08_RS03585	COG3959	Transketolase, thiamine diphosphate binding domain
AKJ08_RS03590	COG3958	Transketolase
AKJ08_RS03595	COG2884	Cell division ATP-binding protein ftsE
AKJ08_RS03600	COG2177	Part of the ABC transporter FtsEX involved in
AKJ08_RS03610	COG2267	carboxylic ester hydrolase activity
AKJ08_RS03615	COG0793	Belongs to the peptidase S41A family
AKJ08_RS03625	COG0443	Heat shock 70 kDa protein
AKJ08_RS03630	COG2766	serine protein kinase
AKJ08_RS03660	COG4565	transcriptional regulatory protein
AKJ08_RS03675	COG2204	response regulator
AKJ08_RS03705	COG0110	maltose O-acetyltransferase activity
AKJ08_RS03740	COG0604	alcohol dehydrogenase
AKJ08_RS03745	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKJ08_RS03760	COG2030	dehydratase
AKJ08_RS03775	COG1253	flavin adenine dinucleotide binding
AKJ08_RS03785	COG1846	Transcriptional regulator
AKJ08_RS03795	COG0741	lytic transglycosylase activity
AKJ08_RS03810	COG0166	Belongs to the GPI family
AKJ08_RS03815	COG0204	Acyl-transferase
AKJ08_RS03825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AKJ08_RS03880	COG0515	serine threonine protein kinase
AKJ08_RS03880	COG2815	serine threonine protein kinase
AKJ08_RS03890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKJ08_RS03890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKJ08_RS03925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKJ08_RS03930	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AKJ08_RS03935	COG1438	arginine binding
AKJ08_RS03940	COG0137	argininosuccinate synthase activity
AKJ08_RS03945	COG0165	Argininosuccinate lyase
AKJ08_RS03960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKJ08_RS03970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKJ08_RS03975	COG0585	pseudouridine synthase activity
AKJ08_RS04010	COG0513	Belongs to the DEAD box helicase family
AKJ08_RS04025	COG4608	Belongs to the ABC transporter superfamily
AKJ08_RS04030	COG0444	Belongs to the ABC transporter superfamily
AKJ08_RS04035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKJ08_RS04040	COG0601	transmembrane transport
AKJ08_RS04045	COG4166	transmembrane transport
AKJ08_RS04070	COG4783	chaperone-mediated protein folding
AKJ08_RS04085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKJ08_RS04085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKJ08_RS04110	COG0084	hydrolase, TatD family'
AKJ08_RS04130	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AKJ08_RS04150	COG0149	triose-phosphate isomerase activity
AKJ08_RS04170	COG0318	PFAM AMP-dependent synthetase and ligase
AKJ08_RS04190	COG1960	acyl-CoA dehydrogenase activity
AKJ08_RS04200	COG1132	(ABC) transporter
AKJ08_RS04205	COG0517	IMP dehydrogenase activity
AKJ08_RS04215	COG2373	Large extracellular alpha-helical protein
AKJ08_RS04220	COG4953	penicillin-binding protein 1C
AKJ08_RS04240	COG3876	Protein conserved in bacteria
AKJ08_RS04245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKJ08_RS04255	COG0542	response to heat
AKJ08_RS04265	COG0823	Involved in the tonB-independent uptake of proteins
AKJ08_RS04275	COG3854	ATPases associated with a variety of cellular activities
AKJ08_RS04285	COG0742	ribosomal rna small subunit methyltransferase
AKJ08_RS04290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AKJ08_RS04295	COG0436	Aminotransferase
AKJ08_RS04300	COG1278	Cold shock
AKJ08_RS04305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKJ08_RS04315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKJ08_RS04330	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKJ08_RS04355	COG1546	Belongs to the CinA family
AKJ08_RS04355	COG1058	Belongs to the CinA family
AKJ08_RS04370	COG2986	histidine ammonia-lyase
AKJ08_RS04375	COG3830	Belongs to the UPF0237 family
AKJ08_RS04375	COG0560	Phosphoserine phosphatase
AKJ08_RS04385	COG1215	transferase activity, transferring glycosyl groups
AKJ08_RS04390	COG0210	DNA helicase
AKJ08_RS04405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKJ08_RS04415	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AKJ08_RS04420	COG1127	ABC transporter
AKJ08_RS04435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKJ08_RS04460	COG1217	gtp-binding protein TYPA
AKJ08_RS04485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKJ08_RS04495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKJ08_RS04505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKJ08_RS04510	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKJ08_RS04515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKJ08_RS04520	COG0072	phenylalanine-tRNA ligase activity
AKJ08_RS04530	COG0776	regulation of translation
AKJ08_RS04545	COG1994	Peptidase M50
AKJ08_RS04550	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKJ08_RS04555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKJ08_RS04560	COG1187	pseudouridine synthase activity
AKJ08_RS04580	COG0148	phosphopyruvate hydratase activity
AKJ08_RS04585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKJ08_RS04590	COG0517	IMP dehydrogenase activity
AKJ08_RS04595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKJ08_RS04605	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AKJ08_RS04640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKJ08_RS04725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKJ08_RS04735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AKJ08_RS04740	COG0189	ligase activity
AKJ08_RS04765	COG0009	L-threonylcarbamoyladenylate synthase
AKJ08_RS04785	COG4974	Belongs to the 'phage' integrase family
AKJ08_RS04790	COG0534	Mate efflux family protein
AKJ08_RS04795	COG0017	Asparaginyl-tRNA synthetase
AKJ08_RS04800	COG0495	leucyl-tRNA aminoacylation
AKJ08_RS04810	COG0268	Binds directly to 16S ribosomal RNA
AKJ08_RS04815	COG3956	TIGRFAM MazG family protein
AKJ08_RS04835	COG1480	7TM receptor with intracellular HD hydrolase
AKJ08_RS04840	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AKJ08_RS04850	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKJ08_RS04865	COG4591	ABC-type transport system involved in lipoprotein release permease component
AKJ08_RS04870	COG1136	(ABC) transporter
AKJ08_RS04875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKJ08_RS04875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKJ08_RS04880	COG0450	alkyl hydroperoxide reductase
AKJ08_RS04885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKJ08_RS04890	COG0316	Belongs to the HesB IscA family
AKJ08_RS04895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKJ08_RS04905	COG2095	MarC family integral membrane protein
AKJ08_RS04910	COG1132	(ABC) transporter
AKJ08_RS04925	COG0859	PFAM glycosyl transferase family 9
AKJ08_RS04930	COG1663	tetraacyldisaccharide 4'-kinase activity
AKJ08_RS04940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKJ08_RS04940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKJ08_RS04945	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKJ08_RS04945	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKJ08_RS04950	COG2835	tetraacyldisaccharide 4'-kinase activity
AKJ08_RS04955	COG1561	YicC-like family, N-terminal region
AKJ08_RS04960	COG0194	GDP metabolic process
AKJ08_RS04980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AKJ08_RS05010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKJ08_RS05050	COG1570	exodeoxyribonuclease VII activity
AKJ08_RS05060	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS05065	COG0142	geranyltranstransferase activity
AKJ08_RS05080	COG3177	Filamentation induced by cAMP protein fic
AKJ08_RS05095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AKJ08_RS05105	COG1543	Belongs to the glycosyl hydrolase 57 family
AKJ08_RS05130	COG0489	protein tyrosine kinase activity
AKJ08_RS05135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKJ08_RS05140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AKJ08_RS05145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKJ08_RS05175	COG1045	serine acetyltransferase
AKJ08_RS05205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKJ08_RS05220	COG0443	Heat shock 70 kDa protein
AKJ08_RS05225	COG0484	heat shock protein binding
AKJ08_RS05250	COG0613	PHP domain protein
AKJ08_RS05255	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKJ08_RS05260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKJ08_RS05270	COG0649	NAD binding
AKJ08_RS05275	COG1034	ATP synthesis coupled electron transport
AKJ08_RS05280	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AKJ08_RS05285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AKJ08_RS05295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKJ08_RS05300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKJ08_RS05345	COG0025	NhaP-type Na H and K H
AKJ08_RS05380	COG3344	reverse transcriptase
AKJ08_RS05385	COG1509	lysine 2,3-aminomutase activity
AKJ08_RS05455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKJ08_RS05460	COG2385	sporulation resulting in formation of a cellular spore
AKJ08_RS05495	COG1329	Transcriptional regulator
AKJ08_RS05500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKJ08_RS05500	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKJ08_RS05515	COG0556	nucleotide-excision repair
AKJ08_RS05520	COG2234	aminopeptidase activity
AKJ08_RS05530	COG0322	excinuclease ABC activity
AKJ08_RS05560	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AKJ08_RS05565	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AKJ08_RS05570	COG1324	tolerance protein
AKJ08_RS05615	COG1489	DNA binding
AKJ08_RS05625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKJ08_RS05640	COG1725	Transcriptional regulator
AKJ08_RS05735	COG0750	zinc metalloprotease
AKJ08_RS05755	COG1902	pentaerythritol trinitrate reductase activity
AKJ08_RS05820	COG0534	Mate efflux family protein
AKJ08_RS05840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AKJ08_RS05860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKJ08_RS05905	COG5006	permease, DMT superfamily
AKJ08_RS05915	COG0482	sulfurtransferase activity
AKJ08_RS05920	COG0183	Belongs to the thiolase family
AKJ08_RS05925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AKJ08_RS05930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AKJ08_RS05935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKJ08_RS05940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKJ08_RS05955	COG2259	Doxx family
AKJ08_RS05965	COG3220	belongs to the UPF0276 family
AKJ08_RS05980	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_RS06010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKJ08_RS06050	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS06055	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKJ08_RS06065	COG1024	Enoyl-CoA hydratase
AKJ08_RS06070	COG1960	acyl-CoA dehydrogenase activity
AKJ08_RS06080	COG1960	acyl-CoA dehydrogenase activity
AKJ08_RS06090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKJ08_RS06090	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKJ08_RS06095	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKJ08_RS06095	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKJ08_RS06125	COG0596	Alpha beta hydrolase
AKJ08_RS06135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AKJ08_RS06165	COG0577	efflux transmembrane transporter activity
AKJ08_RS06165	COG1136	(ABC) transporter
AKJ08_RS06170	COG1136	(ABC) transporter
AKJ08_RS06175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKJ08_RS06200	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AKJ08_RS06205	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS06215	COG2267	carboxylic ester hydrolase activity
AKJ08_RS06230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AKJ08_RS06240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKJ08_RS06245	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AKJ08_RS06250	COG0741	lytic transglycosylase activity
AKJ08_RS06260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKJ08_RS06265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKJ08_RS06265	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AKJ08_RS06295	COG1494	fructose-1,6-bisphosphatase
AKJ08_RS06300	COG0616	signal peptide processing
AKJ08_RS06305	COG0489	protein tyrosine kinase activity
AKJ08_RS06320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKJ08_RS06340	COG0586	Pfam SNARE associated Golgi protein
AKJ08_RS06350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKJ08_RS06350	COG0519	Catalyzes the synthesis of GMP from XMP
AKJ08_RS06370	COG1971	Probably functions as a manganese efflux pump
AKJ08_RS06405	COG3811	Belongs to the UPF0386 family
AKJ08_RS06455	COG1201	RNA secondary structure unwinding
AKJ08_RS06460	COG1715	Restriction endonuclease
AKJ08_RS06550	COG0564	pseudouridine synthase activity
AKJ08_RS06560	COG3119	arylsulfatase activity
AKJ08_RS06590	COG1160	GTP binding
AKJ08_RS06605	COG0571	ribonuclease III activity
AKJ08_RS06615	COG1703	isobutyryl-CoA mutase activity
AKJ08_RS06620	COG1960	acyl-CoA dehydrogenase activity
AKJ08_RS06625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKJ08_RS06640	COG4771	TonB-dependent receptor
AKJ08_RS06650	COG3720	iron ion transport
AKJ08_RS06655	COG4558	Periplasmic binding protein
AKJ08_RS06660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKJ08_RS06665	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AKJ08_RS06670	COG1024	Enoyl-CoA hydratase
AKJ08_RS06675	COG0515	serine threonine protein kinase
AKJ08_RS06680	COG5002	protein histidine kinase activity
AKJ08_RS06685	COG0784	Response regulator, receiver
AKJ08_RS06685	COG2205	protein histidine kinase activity
AKJ08_RS06690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKJ08_RS06695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKJ08_RS06720	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKJ08_RS06725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKJ08_RS06730	COG0277	FAD linked oxidase domain protein
AKJ08_RS06735	COG0302	gtp cyclohydrolase
AKJ08_RS06740	COG0720	synthase
AKJ08_RS06765	COG3411	Ferredoxin
AKJ08_RS06770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKJ08_RS06790	COG4932	domain protein
AKJ08_RS06790	COG5492	domain, Protein
AKJ08_RS06805	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKJ08_RS06830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AKJ08_RS06850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKJ08_RS06875	COG0045	succinate-CoA ligase (ADP-forming) activity
AKJ08_RS06885	COG1053	succinate dehydrogenase
AKJ08_RS06920	COG0505	Belongs to the CarA family
AKJ08_RS06930	COG0540	Belongs to the ATCase OTCase family
AKJ08_RS06935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKJ08_RS06950	COG0681	Belongs to the peptidase S26 family
AKJ08_RS06955	COG0481	GTPase activity
AKJ08_RS06985	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AKJ08_RS06995	COG0616	signal peptide processing
AKJ08_RS07010	COG1496	oxidoreductase activity
AKJ08_RS07020	COG1196	nuclear chromosome segregation
AKJ08_RS07020	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS07040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AKJ08_RS07045	COG0438	transferase activity, transferring glycosyl groups
AKJ08_RS07065	COG2322	membrane
AKJ08_RS07070	COG1999	signal sequence binding
AKJ08_RS07075	COG0109	protoheme IX farnesyltransferase activity
AKJ08_RS07085	COG0288	reversible hydration of carbon dioxide
AKJ08_RS07090	COG4608	Belongs to the ABC transporter superfamily
AKJ08_RS07100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AKJ08_RS07105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKJ08_RS07110	COG0601	transmembrane transport
AKJ08_RS07160	COG2340	Cysteine-rich secretory protein family
AKJ08_RS07175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKJ08_RS07175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKJ08_RS07195	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AKJ08_RS07210	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKJ08_RS07215	COG0463	Glycosyl transferase, family 2
AKJ08_RS07260	COG0735	belongs to the Fur family
AKJ08_RS07280	COG0628	permease
AKJ08_RS07285	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_RS07290	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKJ08_RS07300	COG0113	porphobilinogen synthase activity
AKJ08_RS07305	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AKJ08_RS07330	COG0151	Belongs to the GarS family
AKJ08_RS07340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKJ08_RS07355	COG0443	Heat shock 70 kDa protein
AKJ08_RS07430	COG1671	Belongs to the UPF0178 family
AKJ08_RS07445	COG0653	protein targeting
AKJ08_RS07470	COG0737	Belongs to the 5'-nucleotidase family
AKJ08_RS07480	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_RS07540	COG1595	DNA-templated transcription, initiation
AKJ08_RS07555	COG1742	UPF0060 membrane protein
AKJ08_RS07560	COG1733	regulation of RNA biosynthetic process
AKJ08_RS07620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AKJ08_RS07630	COG1335	isochorismatase
AKJ08_RS07655	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKJ08_RS07725	COG0346	lactoylglutathione lyase activity
AKJ08_RS07740	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKJ08_RS07745	COG0022	dehydrogenase e1 component
AKJ08_RS07750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKJ08_RS07765	COG0181	hydroxymethylbilane synthase activity
AKJ08_RS07770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKJ08_RS07775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKJ08_RS07785	COG3118	belongs to the thioredoxin family
AKJ08_RS07790	COG0772	Belongs to the SEDS family
AKJ08_RS07795	COG0768	penicillin binding
AKJ08_RS07820	COG0424	maF-like protein
AKJ08_RS07835	COG0737	Belongs to the 5'-nucleotidase family
AKJ08_RS07880	COG4464	protein tyrosine phosphatase activity
AKJ08_RS07885	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AKJ08_RS07905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKJ08_RS07905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKJ08_RS07920	COG0217	transcriptional regulatory protein
AKJ08_RS07940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKJ08_RS07945	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKJ08_RS07945	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKJ08_RS07955	COG3485	protocatechuate 3,4-dioxygenase
AKJ08_RS07960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKJ08_RS07960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKJ08_RS07965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKJ08_RS07975	COG0698	ribose 5-phosphate isomerase
AKJ08_RS07980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKJ08_RS07985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKJ08_RS07990	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_RS07995	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AKJ08_RS08005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKJ08_RS08025	COG2046	Belongs to the sulfate adenylyltransferase family
AKJ08_RS08025	COG0529	Catalyzes the synthesis of activated sulfate
AKJ08_RS08030	COG3189	MarR family transcriptional regulator
AKJ08_RS08035	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AKJ08_RS08040	COG0488	(ABC) transporter
AKJ08_RS08045	COG2814	Major facilitator Superfamily
AKJ08_RS08070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKJ08_RS08105	COG0705	Rhomboid family
AKJ08_RS08105	COG0457	Tetratricopeptide repeat
AKJ08_RS08110	COG0668	transmembrane transport
AKJ08_RS08115	COG0564	pseudouridine synthase activity
AKJ08_RS08125	COG0484	heat shock protein binding
AKJ08_RS08130	COG0455	bacterial-type flagellum organization
AKJ08_RS08140	COG1921	L-seryl-tRNASec selenium transferase activity
AKJ08_RS08145	COG0741	lytic transglycosylase activity
AKJ08_RS08150	COG3852	Histidine kinase
AKJ08_RS08155	COG2204	response regulator
AKJ08_RS08160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AKJ08_RS08165	COG0792	nuclease activity
AKJ08_RS08175	COG0335	large ribosomal subunit rRNA binding
AKJ08_RS08195	COG0228	four-way junction DNA binding
AKJ08_RS08205	COG1127	ABC transporter
AKJ08_RS08215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKJ08_RS08240	COG0564	pseudouridine synthase activity
AKJ08_RS08250	COG0612	Peptidase, M16
AKJ08_RS08260	COG1858	cytochrome C peroxidase
AKJ08_RS08280	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AKJ08_RS08290	COG0543	2 iron, 2 sulfur cluster binding
AKJ08_RS08290	COG0493	'glutamate synthase
AKJ08_RS08370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AKJ08_RS08445	COG2826	transposase and inactivated derivatives, IS30 family
AKJ08_RS08470	COG2814	Major facilitator Superfamily
AKJ08_RS08485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKJ08_RS08490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AKJ08_RS08490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKJ08_RS08495	COG0180	Tryptophanyl-tRNA synthetase
AKJ08_RS08505	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AKJ08_RS08515	COG2255	four-way junction helicase activity
AKJ08_RS08525	COG0632	four-way junction helicase activity
AKJ08_RS08530	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AKJ08_RS08535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKJ08_RS08550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AKJ08_RS08560	COG1214	PFAM Peptidase M22, glycoprotease
AKJ08_RS08565	COG0750	zinc metalloprotease
AKJ08_RS08575	COG4589	Belongs to the CDS family
AKJ08_RS08580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKJ08_RS08600	COG1484	DNA-dependent DNA replication
AKJ08_RS08610	COG1131	(ABC) transporter
AKJ08_RS08640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKJ08_RS08645	COG0459	protein refolding
AKJ08_RS08680	COG1196	nuclear chromosome segregation
AKJ08_RS08705	COG2204	response regulator
AKJ08_RS08715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKJ08_RS08725	COG1755	Isoprenylcysteine carboxyl methyltransferase
AKJ08_RS08735	COG0318	PFAM AMP-dependent synthetase and ligase
AKJ08_RS08750	COG1595	DNA-templated transcription, initiation
AKJ08_RS08755	COG3872	metal-dependent enzyme
AKJ08_RS08760	COG0254	rRNA binding
AKJ08_RS08765	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AKJ08_RS08770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKJ08_RS08775	COG1254	Belongs to the acylphosphatase family
AKJ08_RS08780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKJ08_RS08795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AKJ08_RS08795	COG4651	solute:proton antiporter activity
AKJ08_RS08800	COG0539	negative regulation of cytoplasmic translation
AKJ08_RS08810	COG0739	heme binding
AKJ08_RS08815	COG0724	RNA recognition motif
AKJ08_RS08825	COG1166	arginine decarboxylase activity
AKJ08_RS08830	COG0443	Heat shock 70 kDa protein
AKJ08_RS08855	COG1012	belongs to the aldehyde dehydrogenase family
AKJ08_RS08860	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKJ08_RS08900	COG1090	epimerase
AKJ08_RS08910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKJ08_RS08930	COG1335	isochorismatase
AKJ08_RS08940	COG1294	oxidase, subunit
AKJ08_RS08945	COG1271	oxidase subunit
AKJ08_RS08955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKJ08_RS08990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKJ08_RS09020	COG0436	Aminotransferase
AKJ08_RS09025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKJ08_RS09030	COG3494	Protein of unknown function (DUF1009)
AKJ08_RS09035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKJ08_RS09040	COG0505	Belongs to the CarA family
AKJ08_RS09070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKJ08_RS09090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKJ08_RS09120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKJ08_RS09180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKJ08_RS09190	COG0183	Belongs to the thiolase family
AKJ08_RS09200	COG0473	3-isopropylmalate dehydrogenase activity
AKJ08_RS09210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKJ08_RS09220	COG0805	protein transport
AKJ08_RS09225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKJ08_RS09245	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AKJ08_RS09250	COG0564	pseudouridine synthase activity
AKJ08_RS09265	COG0427	acetyl-CoA hydrolase
AKJ08_RS09300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKJ08_RS09315	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AKJ08_RS09335	COG0456	acetyltransferase
AKJ08_RS09350	COG1450	Type ii and iii secretion system protein
AKJ08_RS09370	COG0751	glycine-tRNA ligase activity
AKJ08_RS09375	COG0752	glycyl-tRNA synthetase alpha subunit
AKJ08_RS09390	COG2183	response to ionizing radiation
AKJ08_RS09390	COG0539	negative regulation of cytoplasmic translation
AKJ08_RS09395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKJ08_RS09400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKJ08_RS09405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKJ08_RS09410	COG0825	malonyl-CoA metabolic process
AKJ08_RS09420	COG3973	AAA domain
AKJ08_RS09425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AKJ08_RS09430	COG0124	histidyl-tRNA synthetase
AKJ08_RS09435	COG0688	phosphatidylethanolamine metabolic process
AKJ08_RS09465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKJ08_RS09475	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AKJ08_RS09480	COG0631	protein serine/threonine phosphatase activity
AKJ08_RS09525	COG0203	ribosomal protein L17
AKJ08_RS09540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKJ08_RS09545	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AKJ08_RS09550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AKJ08_RS09560	COG0563	adenylate kinase activity
AKJ08_RS09565	COG0201	protein transport
AKJ08_RS09570	COG0200	Binds to the 23S rRNA
AKJ08_RS09580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKJ08_RS09585	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKJ08_RS09590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKJ08_RS09595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKJ08_RS09605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AKJ08_RS09610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKJ08_RS09615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKJ08_RS09620	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKJ08_RS09625	COG0255	Belongs to the universal ribosomal protein uL29 family
AKJ08_RS09630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AKJ08_RS09645	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKJ08_RS09655	COG0089	rRNA binding
AKJ08_RS09660	COG0088	Forms part of the polypeptide exit tunnel
AKJ08_RS09665	COG0051	transcription antitermination factor activity, RNA binding
AKJ08_RS09670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKJ08_RS09675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKJ08_RS09680	COG0049	tRNA binding
AKJ08_RS09685	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKJ08_RS09730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKJ08_RS09750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKJ08_RS09755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKJ08_RS09775	COG1228	amidohydrolase
AKJ08_RS09805	COG2201	protein-glutamate methylesterase activity
AKJ08_RS09815	COG2201	protein-glutamate methylesterase activity
AKJ08_RS09820	COG0500	methyltransferase
AKJ08_RS09825	COG3844	kynureninase activity
AKJ08_RS09830	COG3483	tryptophan 2,3-dioxygenase activity
AKJ08_RS09835	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AKJ08_RS09840	COG0802	atpase or kinase
AKJ08_RS09845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AKJ08_RS09845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AKJ08_RS09850	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AKJ08_RS09860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKJ08_RS09865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKJ08_RS09875	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AKJ08_RS09880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKJ08_RS09885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKJ08_RS09890	COG0037	tRNA processing
AKJ08_RS09905	COG3246	L-lysine catabolic process to acetate
AKJ08_RS09910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKJ08_RS09930	COG1607	acyl-coa hydrolase
AKJ08_RS09970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AKJ08_RS09975	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AKJ08_RS09985	COG1011	Hydrolase
AKJ08_RS10000	COG0604	alcohol dehydrogenase
AKJ08_RS10005	COG0330	HflC and HflK could
AKJ08_RS10010	COG0616	signal peptide processing
AKJ08_RS10015	COG1573	uracil-dna glycosylase
AKJ08_RS10025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKJ08_RS10050	COG0686	Belongs to the AlaDH PNT family
AKJ08_RS10055	COG1595	DNA-templated transcription, initiation
AKJ08_RS10080	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKJ08_RS10085	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AKJ08_RS10085	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AKJ08_RS10100	COG0525	valine-tRNA ligase activity
AKJ08_RS10105	COG0784	Response regulator, receiver
AKJ08_RS10115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AKJ08_RS10115	COG2010	Cytochrome c
AKJ08_RS10120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AKJ08_RS10125	COG0085	RNA polymerase activity
AKJ08_RS10130	COG0222	ribosome binding
AKJ08_RS10135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKJ08_RS10140	COG0081	regulation of translation
AKJ08_RS10145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKJ08_RS10165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKJ08_RS10170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKJ08_RS10195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKJ08_RS10205	COG0189	ligase activity
AKJ08_RS10220	COG0443	Heat shock 70 kDa protein
AKJ08_RS10230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKJ08_RS10255	COG0110	maltose O-acetyltransferase activity
AKJ08_RS10310	COG0022	dehydrogenase e1 component
AKJ08_RS10320	COG1183	phosphatidylcholine synthase activity
AKJ08_RS10345	COG5002	protein histidine kinase activity
AKJ08_RS10355	COG1193	negative regulation of DNA recombination
AKJ08_RS10365	COG0557	exoribonuclease II activity
AKJ08_RS10375	COG0789	Transcriptional regulator
AKJ08_RS10385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKJ08_RS10395	COG0022	dehydrogenase e1 component
AKJ08_RS10400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKJ08_RS10405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKJ08_RS10415	COG1012	belongs to the aldehyde dehydrogenase family
AKJ08_RS10420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKJ08_RS10420	COG2022	thiamine diphosphate biosynthetic process
AKJ08_RS10430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKJ08_RS10445	COG0101	tRNA pseudouridine synthase activity
AKJ08_RS10455	COG1606	tRNA processing
AKJ08_RS10460	COG2046	Belongs to the sulfate adenylyltransferase family
AKJ08_RS10460	COG0529	Catalyzes the synthesis of activated sulfate
AKJ08_RS10475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKJ08_RS10480	COG4585	Histidine kinase
AKJ08_RS10485	COG2197	response regulator
AKJ08_RS10505	COG2086	electron transfer activity
AKJ08_RS10510	COG1960	acyl-CoA dehydrogenase activity
AKJ08_RS10515	COG1309	transcriptional regulator
AKJ08_RS10565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AKJ08_RS10570	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKJ08_RS10575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKJ08_RS10580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKJ08_RS10595	COG2715	membrane protein required for spore maturation
AKJ08_RS10600	COG0700	Nucleoside recognition
AKJ08_RS10605	COG2894	cell division
AKJ08_RS10645	COG0785	Cytochrome C biogenesis protein
AKJ08_RS10655	COG1595	DNA-templated transcription, initiation
AKJ08_RS10665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKJ08_RS10670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKJ08_RS10675	COG0242	peptide deformylase activity
AKJ08_RS10680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKJ08_RS10695	COG1183	phosphatidylcholine synthase activity
AKJ08_RS10700	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKJ08_RS10705	COG1546	Belongs to the CinA family
AKJ08_RS10705	COG1058	Belongs to the CinA family
AKJ08_RS10720	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AKJ08_RS10725	COG1309	transcriptional regulator
AKJ08_RS10745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKJ08_RS10750	COG1596	polysaccharide export
AKJ08_RS10765	COG1100	Small GTP-binding protein
AKJ08_RS10775	COG1428	Deoxynucleoside kinase
AKJ08_RS10780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKJ08_RS10785	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKJ08_RS10790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKJ08_RS10795	COG0037	tRNA processing
AKJ08_RS10800	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AKJ08_RS10805	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKJ08_RS10830	COG0631	protein serine/threonine phosphatase activity
AKJ08_RS10835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKJ08_RS10845	COG1215	transferase activity, transferring glycosyl groups
AKJ08_RS10880	COG0626	cystathionine gamma-synthase activity
AKJ08_RS10890	COG1131	(ABC) transporter
AKJ08_RS10915	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AKJ08_RS10925	COG0673	inositol 2-dehydrogenase activity
AKJ08_RS10935	COG0714	Associated with various cellular activities
AKJ08_RS10940	COG0515	serine threonine protein kinase
AKJ08_RS10955	COG1024	Enoyl-CoA hydratase
AKJ08_RS10960	COG5016	pyruvate
AKJ08_RS10960	COG0511	ligase activity, forming carbon-carbon bonds
AKJ08_RS10965	COG0439	Biotin carboxylase
AKJ08_RS10970	COG1278	Cold shock
AKJ08_RS10975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKJ08_RS11000	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKJ08_RS11005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKJ08_RS11015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKJ08_RS11020	COG0772	Belongs to the SEDS family
AKJ08_RS11025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKJ08_RS11030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKJ08_RS11035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKJ08_RS11040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKJ08_RS11050	COG3116	cell division
AKJ08_RS11065	COG2001	Belongs to the MraZ family
AKJ08_RS11070	COG0438	transferase activity, transferring glycosyl groups
AKJ08_RS11085	COG0596	Alpha beta hydrolase
AKJ08_RS11135	COG0174	glutamine synthetase
AKJ08_RS11140	COG0519	Catalyzes the synthesis of GMP from XMP
AKJ08_RS11145	COG1012	belongs to the aldehyde dehydrogenase family
AKJ08_RS11185	COG2975	iron-sulfur cluster assembly
AKJ08_RS11190	COG0633	Ferredoxin
AKJ08_RS11195	COG0443	Heat shock 70 kDa protein
AKJ08_RS11205	COG0316	Belongs to the HesB IscA family
AKJ08_RS11210	COG0822	iron-sulfur transferase activity
AKJ08_RS11215	COG1104	cysteine desulfurase activity
AKJ08_RS11220	COG4232	protein-disulfide reductase activity
AKJ08_RS11225	COG0515	serine threonine protein kinase
AKJ08_RS11260	COG4191	Histidine kinase
AKJ08_RS11265	COG0612	Peptidase, M16
AKJ08_RS11290	COG0793	Belongs to the peptidase S41A family
AKJ08_RS11305	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AKJ08_RS11310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKJ08_RS11315	COG2088	sporulation resulting in formation of a cellular spore
AKJ08_RS11320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AKJ08_RS11335	COG0360	Binds together with S18 to 16S ribosomal RNA
AKJ08_RS11340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AKJ08_RS11345	COG0359	binds to the 23S rRNA
AKJ08_RS11350	COG0305	Participates in initiation and elongation during chromosome replication
AKJ08_RS11375	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AKJ08_RS11380	COG0352	thiamine-phosphate diphosphorylase activity
AKJ08_RS11395	COG0463	Glycosyl transferase, family 2
AKJ08_RS11410	COG0542	response to heat
AKJ08_RS11435	COG0514	ATP-dependent DNA helicase (RecQ)
AKJ08_RS11435	COG0514	ATP-dependent DNA helicase (RecQ)
AKJ08_RS11440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKJ08_RS11445	COG2890	protein-(glutamine-N5) methyltransferase activity
AKJ08_RS11450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKJ08_RS11485	COG2827	Endonuclease containing a URI domain
AKJ08_RS11500	COG4269	membrane
AKJ08_RS11505	COG0501	Belongs to the peptidase M48B family
AKJ08_RS11530	COG2226	methyltransferase
AKJ08_RS11600	COG2132	Multicopper oxidase
AKJ08_RS11605	COG0789	Transcriptional regulator
AKJ08_RS11610	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKJ08_RS11615	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_RS11625	COG1360	Flagellar Motor Protein
AKJ08_RS11645	COG3706	GGDEF domain
AKJ08_RS11650	COG3706	GGDEF domain
AKJ08_RS11675	COG4294	response to UV
AKJ08_RS11680	COG4932	domain protein
AKJ08_RS11680	COG5492	domain, Protein
AKJ08_RS11710	COG0546	phosphoglycolate phosphatase activity
AKJ08_RS11730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKJ08_RS11745	COG4106	trans-aconitate 2-methyltransferase activity
AKJ08_RS11750	COG2267	carboxylic ester hydrolase activity
AKJ08_RS11755	COG0156	8-amino-7-oxononanoate synthase activity
AKJ08_RS11765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKJ08_RS11775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKJ08_RS11780	COG5002	protein histidine kinase activity
AKJ08_RS11785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKJ08_RS11795	COG2239	Acts as a magnesium transporter
AKJ08_RS11805	COG0420	3'-5' exonuclease activity
AKJ08_RS11810	COG2183	response to ionizing radiation
AKJ08_RS11815	COG0668	transmembrane transport
AKJ08_RS11820	COG2070	2-Nitropropane dioxygenase
AKJ08_RS11820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AKJ08_RS11825	COG3321	synthase
AKJ08_RS11825	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_RS11825	COG4221	oxidoreductase activity
AKJ08_RS11825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKJ08_RS11830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKJ08_RS11835	COG0596	Alpha beta hydrolase
AKJ08_RS11840	COG0318	PFAM AMP-dependent synthetase and ligase
AKJ08_RS11845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKJ08_RS11860	COG3263	regulation of cellular component size
AKJ08_RS11890	COG0513	Belongs to the DEAD box helicase family
AKJ08_RS11895	COG0708	Exodeoxyribonuclease III
AKJ08_RS11910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AKJ08_RS11965	COG1131	(ABC) transporter
AKJ08_RS11970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKJ08_RS11985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKJ08_RS11990	COG4932	domain protein
AKJ08_RS11990	COG5492	domain, Protein
AKJ08_RS11995	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AKJ08_RS12025	COG0501	Belongs to the peptidase M48B family
AKJ08_RS12035	COG0616	signal peptide processing
AKJ08_RS12050	COG5002	protein histidine kinase activity
AKJ08_RS12060	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AKJ08_RS12065	COG0784	Response regulator, receiver
AKJ08_RS12065	COG2205	protein histidine kinase activity
AKJ08_RS12065	COG5002	protein histidine kinase activity
AKJ08_RS12075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AKJ08_RS12080	COG0573	inorganic phosphate transmembrane transporter activity
AKJ08_RS12085	COG0581	inorganic phosphate transmembrane transporter activity
AKJ08_RS12090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKJ08_RS12120	COG0583	DNA-binding transcription factor activity
AKJ08_RS12155	COG0656	L-ascorbic acid biosynthetic process
AKJ08_RS12180	COG0811	peptide transport
AKJ08_RS12205	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS12230	COG0811	peptide transport
AKJ08_RS12350	COG1418	mRNA catabolic process
AKJ08_RS12380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKJ08_RS12385	COG2264	protein methyltransferase activity
AKJ08_RS12390	COG0612	Peptidase, M16
AKJ08_RS12410	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AKJ08_RS12415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKJ08_RS12420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AKJ08_RS12425	COG2197	response regulator
AKJ08_RS12445	COG0492	ferredoxin-NADP+ reductase activity
AKJ08_RS12450	COG2003	Belongs to the UPF0758 family
AKJ08_RS12480	COG0629	single-stranded DNA binding
AKJ08_RS12485	COG2027	D-alanyl-D-alanine carboxypeptidase
AKJ08_RS12490	COG4166	transmembrane transport
AKJ08_RS12505	COG1295	ribonuclease BN
AKJ08_RS12515	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AKJ08_RS12520	COG1278	Cold shock
AKJ08_RS12525	COG2840	Smr protein MutS2
AKJ08_RS12530	COG3483	tryptophan 2,3-dioxygenase activity
AKJ08_RS12570	COG2267	carboxylic ester hydrolase activity
AKJ08_RS12580	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_RS12610	COG1846	Transcriptional regulator
AKJ08_RS12615	COG1136	(ABC) transporter
AKJ08_RS12625	COG0577	efflux transmembrane transporter activity
AKJ08_RS12625	COG1136	(ABC) transporter
AKJ08_RS12680	COG0346	lactoylglutathione lyase activity
AKJ08_RS12685	COG0300	oxidoreductase activity
AKJ08_RS12690	COG1252	NADH dehydrogenase
AKJ08_RS12695	COG0352	thiamine-phosphate diphosphorylase activity
AKJ08_RS12695	COG0351	phosphomethylpyrimidine kinase
AKJ08_RS12700	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_RS12710	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKJ08_RS12710	COG3620	sequence-specific DNA binding
AKJ08_RS12710	COG0617	tRNA 3'-terminal CCA addition
AKJ08_RS12715	COG0617	tRNA 3'-terminal CCA addition
AKJ08_RS12715	COG0517	IMP dehydrogenase activity
AKJ08_RS12715	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKJ08_RS12725	COG3118	belongs to the thioredoxin family
AKJ08_RS12785	COG1192	Involved in chromosome partitioning
AKJ08_RS12805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKJ08_RS12810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKJ08_RS12815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKJ08_RS12820	COG3716	PTS system mannose fructose sorbose family IID component
AKJ08_RS12830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKJ08_RS12835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKJ08_RS12835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKJ08_RS12840	COG1660	Displays ATPase and GTPase activities
AKJ08_RS12845	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AKJ08_RS12850	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS12855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKJ08_RS12880	COG1560	Kdo2-lipid A biosynthetic process
AKJ08_RS12885	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AKJ08_RS12900	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AKJ08_RS12940	COG1024	Enoyl-CoA hydratase
AKJ08_RS12945	COG0251	oxidation-reduction process
AKJ08_RS12990	COG1160	GTP binding
AKJ08_RS13005	COG1960	acyl-CoA dehydrogenase activity
AKJ08_RS13010	COG0824	Thioesterase
AKJ08_RS13030	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKJ08_RS13045	COG1040	competence protein
AKJ08_RS13055	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKJ08_RS13060	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AKJ08_RS13065	COG0799	negative regulation of ribosome biogenesis
AKJ08_RS13075	COG0429	hydrolase of the alpha beta-hydrolase fold
AKJ08_RS13080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKJ08_RS13100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AKJ08_RS13105	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKJ08_RS13110	COG4221	oxidoreductase activity
AKJ08_RS13115	COG2259	Doxx family
AKJ08_RS13120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AKJ08_RS13135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AKJ08_RS13160	COG4206	TonB-dependent receptor
AKJ08_RS13175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKJ08_RS13195	COG1120	ATPase activity
AKJ08_RS13200	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AKJ08_RS13210	COG1490	D-aminoacyl-tRNA deacylase activity
AKJ08_RS13220	COG3138	arginine N-succinyltransferase
AKJ08_RS13240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKJ08_RS13245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKJ08_RS13265	COG1331	Highly conserved protein containing a thioredoxin domain
AKJ08_RS13275	COG2204	response regulator
AKJ08_RS13280	COG3961	Belongs to the TPP enzyme family
AKJ08_RS13290	COG0729	surface antigen
AKJ08_RS13300	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AKJ08_RS13340	COG1940	carbohydrate kinase activity
AKJ08_RS13375	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS13445	COG2801	Transposase and inactivated derivatives
AKJ08_RS13455	COG0494	nUDIX hydrolase
AKJ08_RS13460	COG1968	undecaprenyl-diphosphatase activity
AKJ08_RS13465	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AKJ08_RS13475	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKJ08_RS13475	COG1024	Enoyl-CoA hydratase
AKJ08_RS13540	COG3387	PFAM Glycoside hydrolase 15-related
AKJ08_RS13550	COG3158	transport of potassium into the cell
AKJ08_RS13555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AKJ08_RS13565	COG0523	cobalamin synthesis protein
AKJ08_RS13575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AKJ08_RS13580	COG1309	transcriptional regulator
AKJ08_RS13585	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AKJ08_RS13605	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AKJ08_RS13610	COG1253	flavin adenine dinucleotide binding
AKJ08_RS13635	COG3104	oligopeptide transport
AKJ08_RS13640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKJ08_RS13700	COG2201	protein-glutamate methylesterase activity
AKJ08_RS13710	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS13730	COG1234	tRNA 3'-trailer cleavage
AKJ08_RS13740	COG2826	transposase and inactivated derivatives, IS30 family
AKJ08_RS13755	COG0488	(ABC) transporter
AKJ08_RS13765	COG2267	carboxylic ester hydrolase activity
AKJ08_RS13780	COG1994	Peptidase M50
AKJ08_RS13790	COG0564	pseudouridine synthase activity
AKJ08_RS13800	COG0842	Transport permease protein
AKJ08_RS13805	COG1131	(ABC) transporter
AKJ08_RS13810	COG0372	Belongs to the citrate synthase family
AKJ08_RS13815	COG5002	protein histidine kinase activity
AKJ08_RS13820	COG4413	Urea transporter
AKJ08_RS13825	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AKJ08_RS13830	COG0830	nickel cation binding
AKJ08_RS13835	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AKJ08_RS13840	COG0804	urea catabolic process
AKJ08_RS13845	COG0832	Belongs to the urease beta subunit family
AKJ08_RS13850	COG0831	urea catabolic process
AKJ08_RS13855	COG0829	nickel cation binding
AKJ08_RS13860	COG3619	membrane
AKJ08_RS13900	COG0730	response to heat
AKJ08_RS13905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKJ08_RS13905	COG3453	Protein conserved in bacteria
AKJ08_RS13910	COG2204	response regulator
AKJ08_RS13915	COG2084	Dehydrogenase
AKJ08_RS13965	COG0450	alkyl hydroperoxide reductase
AKJ08_RS13970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKJ08_RS13985	COG2867	negative regulation of translational initiation
AKJ08_RS14010	COG0023	Translation Initiation Factor
AKJ08_RS14020	COG2207	Transcriptional regulator
AKJ08_RS14030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKJ08_RS14035	COG0584	glycerophosphoryl diester phosphodiesterase
AKJ08_RS14085	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AKJ08_RS14105	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS14110	COG2205	protein histidine kinase activity
AKJ08_RS14115	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKJ08_RS14120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AKJ08_RS14125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKJ08_RS14170	COG2967	ApaG domain
AKJ08_RS14180	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AKJ08_RS14215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKJ08_RS14230	COG2094	Belongs to the DNA glycosylase MPG family
AKJ08_RS14240	COG0728	peptidoglycan biosynthetic process
AKJ08_RS14245	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AKJ08_RS14255	COG2205	protein histidine kinase activity
AKJ08_RS14270	COG0626	cystathionine gamma-synthase activity
AKJ08_RS14290	COG1965	Belongs to the frataxin family
AKJ08_RS14295	COG1612	heme a metabolic process
AKJ08_RS14295	COG0109	protoheme IX farnesyltransferase activity
AKJ08_RS14315	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AKJ08_RS14320	COG0504	CTP synthase activity
AKJ08_RS14340	COG0667	Aldo Keto reductase
AKJ08_RS14355	COG1393	Belongs to the ArsC family
AKJ08_RS14365	COG4106	trans-aconitate 2-methyltransferase activity
AKJ08_RS14390	COG1063	alcohol dehydrogenase
AKJ08_RS14405	COG2814	Major facilitator Superfamily
AKJ08_RS14445	COG4941	Belongs to the sigma-70 factor family
AKJ08_RS14460	COG1247	-acetyltransferase
AKJ08_RS14470	COG0640	Transcriptional regulator
AKJ08_RS14485	COG2130	NADP-dependent
AKJ08_RS14490	COG0024	Methionine aminopeptidase
AKJ08_RS14525	COG2059	Chromate
AKJ08_RS14530	COG2085	NADP oxidoreductase coenzyme F420-dependent
AKJ08_RS14570	COG1012	belongs to the aldehyde dehydrogenase family
AKJ08_RS14580	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AKJ08_RS14580	COG0456	acetyltransferase
AKJ08_RS14605	COG1132	(ABC) transporter
AKJ08_RS14610	COG1132	(ABC) transporter
AKJ08_RS14615	COG0590	tRNA wobble adenosine to inosine editing
AKJ08_RS14650	COG2169	Transcriptional regulator
AKJ08_RS14650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKJ08_RS14675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AKJ08_RS14700	COG3795	YCII-related domain
AKJ08_RS14705	COG2824	Alkylphosphonate utilization operon protein PhnA
AKJ08_RS14740	COG1741	Belongs to the pirin family
AKJ08_RS14770	COG0114	fumarate hydratase activity
AKJ08_RS14795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKJ08_RS14870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKJ08_RS14900	COG4191	Histidine kinase
AKJ08_RS14920	COG1595	DNA-templated transcription, initiation
AKJ08_RS14925	COG5507	3-demethylubiquinone-9 3-methyltransferase
AKJ08_RS14945	COG1595	DNA-templated transcription, initiation
AKJ08_RS14960	COG0625	glutathione transferase activity
AKJ08_RS14975	COG1881	PFAM PEBP family protein
AKJ08_RS14980	COG2826	transposase and inactivated derivatives, IS30 family
AKJ08_RS15020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AKJ08_RS15090	COG0625	glutathione transferase activity
AKJ08_RS15095	COG1309	transcriptional regulator
AKJ08_RS15100	COG1028	Short-chain dehydrogenase reductase Sdr
AKJ08_RS15110	COG4585	Histidine kinase
AKJ08_RS15115	COG2197	response regulator
AKJ08_RS15140	COG1741	Belongs to the pirin family
AKJ08_RS15170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKJ08_RS15175	COG0798	PFAM Bile acid sodium symporter
AKJ08_RS15190	COG0431	NADPH-dependent FMN reductase
AKJ08_RS15195	COG1741	Belongs to the pirin family
AKJ08_RS15200	COG0583	DNA-binding transcription factor activity
AKJ08_RS15205	COG0488	(ABC) transporter
AKJ08_RS15230	COG0596	Alpha beta hydrolase
AKJ08_RS15240	COG0598	Magnesium transport protein CorA
AKJ08_RS15250	COG2818	Glycosylase
AKJ08_RS15280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AKJ08_RS15285	COG2226	methyltransferase
AKJ08_RS15290	COG3177	Filamentation induced by cAMP protein fic
AKJ08_RS15370	COG0640	Transcriptional regulator
AKJ08_RS15375	COG0640	Transcriptional regulator
AKJ08_RS15390	COG1984	allophanate hydrolase subunit 2
AKJ08_RS15420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKJ08_RS15500	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKJ08_RS15510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKJ08_RS15520	COG1024	Enoyl-CoA hydratase
AKJ08_RS15530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKJ08_RS15535	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKJ08_RS15540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKJ08_RS15545	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKJ08_RS15550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKJ08_RS15555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKJ08_RS15565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKJ08_RS15565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKJ08_RS15575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKJ08_RS15580	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS15610	COG2363	Small membrane protein
AKJ08_RS15625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKJ08_RS15640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AKJ08_RS15650	COG5002	protein histidine kinase activity
AKJ08_RS15665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKJ08_RS15670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKJ08_RS15705	COG0437	4 iron, 4 sulfur cluster binding
AKJ08_RS15720	COG1643	Atp-dependent helicase
AKJ08_RS15740	COG1420	regulation of RNA biosynthetic process
AKJ08_RS15745	COG0531	amino acid
AKJ08_RS15750	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AKJ08_RS15760	COG0730	response to heat
AKJ08_RS15765	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKJ08_RS15770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AKJ08_RS15775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKJ08_RS15780	COG0189	ligase activity
AKJ08_RS15780	COG0569	domain protein
AKJ08_RS15795	COG0247	lactate metabolic process
AKJ08_RS15795	COG2181	nitrate reductase activity
AKJ08_RS15840	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKJ08_RS15855	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKJ08_RS15860	COG0594	ribonuclease P activity
AKJ08_RS15865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKJ08_RS15870	COG0706	membrane insertase activity
AKJ08_RS15890	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AKJ08_RS15915	COG0357	Ribosomal RNA small subunit methyltransferase G
AKJ08_RS15925	COG1475	DNA binding
AKJ08_RS15935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKJ08_RS15940	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKJ08_RS15945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKJ08_RS15950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKJ08_RS15970	COG0402	S-adenosylhomocysteine deaminase activity
AKJ08_RS15995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKJ08_RS16000	COG1902	pentaerythritol trinitrate reductase activity
AKJ08_RS16000	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKJ08_RS16005	COG0386	Belongs to the glutathione peroxidase family
AKJ08_RS16015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKJ08_RS16030	COG0733	neurotransmitter:sodium symporter activity
AKJ08_RS16035	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AKJ08_RS16040	COG2855	membrane
AKJ08_RS16050	COG0517	IMP dehydrogenase activity
AKJ08_RS16055	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKJ08_RS16065	COG2353	YceI-like domain
AKJ08_RS16080	COG0300	oxidoreductase activity
AKJ08_RS16085	COG0475	glutathione-regulated potassium exporter activity
AKJ08_RS16090	COG2314	TM2 domain
AKJ08_RS16105	COG1704	LemA family
AKJ08_RS16125	COG2204	response regulator
AKJ08_RS16130	COG5002	protein histidine kinase activity
AKJ08_RS16165	COG0347	Belongs to the P(II) protein family
AKJ08_RS16170	COG3852	Histidine kinase
AKJ08_RS16190	COG0356	it plays a direct role in the translocation of protons across the membrane
AKJ08_RS16195	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKJ08_RS16200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKJ08_RS16205	COG0012	GTP binding
AKJ08_RS16215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKJ08_RS16220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKJ08_RS16225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKJ08_RS16230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKJ08_RS16265	COG1045	serine acetyltransferase
AKJ08_RS16270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKJ08_RS16310	COG2962	Rard protein
AKJ08_RS16315	COG1047	Peptidyl-prolyl cis-trans
AKJ08_RS16345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKJ08_RS16350	COG0443	Heat shock 70 kDa protein
AKJ08_RS16355	COG0284	orotidine-5'-phosphate decarboxylase activity
AKJ08_RS16360	COG0484	heat shock protein binding
AKJ08_RS16410	COG0443	Heat shock 70 kDa protein
AKJ08_RS16415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKJ08_RS16440	COG0667	Aldo Keto reductase
AKJ08_RS16455	COG1741	Belongs to the pirin family
AKJ08_RS16465	COG2346	COG2346, Truncated hemoglobins
AKJ08_RS16480	COG3278	Belongs to the heme-copper respiratory oxidase family
AKJ08_RS16490	COG2010	Cytochrome c
AKJ08_RS16500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKJ08_RS16515	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AKJ08_RS16520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKJ08_RS16550	COG0739	heme binding
AKJ08_RS16570	COG4786	Flagellar basal body rod
AKJ08_RS16575	COG4786	Flagellar basal body rod
AKJ08_RS16600	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKJ08_RS16605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKJ08_RS16610	COG1684	flagellar biosynthetic protein fliR
AKJ08_RS16615	COG1987	bacterial-type flagellum assembly
AKJ08_RS16650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AKJ08_RS16665	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AKJ08_RS16690	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKJ08_RS16700	COG1677	Flagellar hook-basal body complex protein FliE
AKJ08_RS16705	COG1558	bacterial-type flagellum-dependent cell motility
AKJ08_RS16710	COG1815	bacterial-type flagellum-dependent cell motility
AKJ08_RS16725	COG5002	protein histidine kinase activity
AKJ08_RS16750	COG1199	ATP-dependent helicase activity
AKJ08_RS16760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKJ08_RS16765	COG1100	Small GTP-binding protein
AKJ08_RS16770	COG5002	protein histidine kinase activity
AKJ08_RS16770	COG0784	Response regulator, receiver
AKJ08_RS16770	COG2205	protein histidine kinase activity
AKJ08_RS16775	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AKJ08_RS16780	COG0840	transmembrane signaling receptor activity
AKJ08_RS16790	COG0643	Histidine kinase
AKJ08_RS16790	COG2198	Histidine kinase
AKJ08_RS16795	COG1691	(AIR) carboxylase
AKJ08_RS16800	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AKJ08_RS16805	COG0745	RESPONSE REGULATOR receiver
AKJ08_RS16805	COG4191	Histidine kinase
AKJ08_RS16805	COG2205	protein histidine kinase activity
AKJ08_RS16830	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AKJ08_RS16845	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKJ08_RS16850	COG0625	glutathione transferase activity
AKJ08_RS16855	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AKJ08_RS16915	COG0174	glutamine synthetase
AKJ08_RS16935	COG0411	ABC transporter
AKJ08_RS16945	COG0559	Belongs to the binding-protein-dependent transport system permease family
AKJ08_RS16960	COG1472	Belongs to the glycosyl hydrolase 3 family
AKJ08_RS16965	COG5002	protein histidine kinase activity
AKJ08_RS16980	COG0714	Associated with various cellular activities
AKJ08_RS17030	COG0489	protein tyrosine kinase activity
AKJ08_RS17030	COG3206	protein involved in exopolysaccharide biosynthesis
AKJ08_RS17035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKJ08_RS17050	COG0297	glycogen (starch) synthase activity
AKJ08_RS17145	COG2814	Major facilitator Superfamily
AKJ08_RS17160	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AKJ08_RS17165	COG0784	Response regulator, receiver
AKJ08_RS17165	COG2205	protein histidine kinase activity
AKJ08_RS17165	COG5002	protein histidine kinase activity
AKJ08_RS17200	COG0420	3'-5' exonuclease activity
AKJ08_RS17210	COG0667	Aldo Keto reductase
AKJ08_RS17230	COG5002	protein histidine kinase activity
AKJ08_RS17235	COG2204	response regulator
AKJ08_RS17260	COG0697	spore germination
AKJ08_RS17290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKJ08_RS17330	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKJ08_RS17385	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AKJ08_RS17400	COG0662	Cupin 2, conserved barrel domain protein
AKJ08_RS17410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKJ08_RS17425	COG0006	proline dipeptidase activity
AKJ08_RS17445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKJ08_RS17490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKJ08_RS17495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKJ08_RS17525	COG1785	Belongs to the alkaline phosphatase family
AKJ08_RS17530	COG1785	Belongs to the alkaline phosphatase family
AKJ08_RS17545	COG2814	Major facilitator Superfamily
AKJ08_RS17610	COG1247	-acetyltransferase
AKJ08_RS17650	COG0318	PFAM AMP-dependent synthetase and ligase
AKJ08_RS17665	COG1505	serine-type exopeptidase activity
AKJ08_RS17670	COG1505	serine-type exopeptidase activity
AKJ08_RS17690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKJ08_RS17720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKJ08_RS17725	COG1301	dicarboxylic acid transport
AKJ08_RS17730	COG0010	Belongs to the arginase family
AKJ08_RS17735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AKJ08_RS17750	COG0121	glutamine amidotransferase
AKJ08_RS17755	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKJ08_RS17800	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AKJ08_RS17805	COG1064	alcohol dehydrogenase
AKJ08_RS17820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKJ08_RS17820	COG0116	Belongs to the methyltransferase superfamily
AKJ08_RS17825	COG0589	response to stress
AKJ08_RS17840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AKJ08_RS17855	COG2826	transposase and inactivated derivatives, IS30 family
AKJ08_RS17875	COG2814	Major facilitator Superfamily
AKJ08_RS17885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AKJ08_RS17900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKJ08_RS17905	COG0477	Major facilitator Superfamily
AKJ08_RS17910	COG0625	glutathione transferase activity
AKJ08_RS17915	COG0488	(ABC) transporter
AKJ08_RS17920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKJ08_RS17925	COG0271	Belongs to the BolA IbaG family
AKJ08_RS17930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AKJ08_RS17935	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AKJ08_RS17940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKJ08_RS17955	COG1993	acr, cog1993
AKJ08_RS17965	COG0366	Alpha amylase catalytic
AKJ08_RS17995	COG0672	)-iron permease
AKJ08_RS18030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AKJ08_RS18040	COG0516	GMP reductase activity
AKJ08_RS18040	COG0517	IMP dehydrogenase activity
AKJ08_RS18045	COG2205	protein histidine kinase activity
AKJ08_RS18100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKJ08_RS18105	COG0154	amidase activity
AKJ08_RS18110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKJ08_RS18130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKJ08_RS18135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKJ08_RS18140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKJ08_RS18155	COG0483	inositol monophosphate 1-phosphatase activity
AKJ08_RS18160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKJ08_RS18165	COG1666	GTP binding
AKJ08_RS18170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKJ08_RS18200	COG2373	Large extracellular alpha-helical protein