locus-tag	class	description
WCW_RS00035	COG5433	transposase activity
WCW_RS00055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WCW_RS00060	COG2943	transferase activity, transferring hexosyl groups
WCW_RS00065	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
WCW_RS00070	COG1181	Belongs to the D-alanine--D-alanine ligase family
WCW_RS00080	COG0805	protein transport
WCW_RS00085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WCW_RS00090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WCW_RS00105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WCW_RS00130	COG2814	Major facilitator Superfamily
WCW_RS00135	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WCW_RS00140	COG1074	ATP-dependent DNA helicase activity
WCW_RS00145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WCW_RS00170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WCW_RS00255	COG0560	Phosphoserine phosphatase
WCW_RS00260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WCW_RS00280	COG1596	polysaccharide export
WCW_RS00310	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
WCW_RS00325	COG0814	amino acid
WCW_RS00340	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WCW_RS00350	COG1022	Amp-dependent synthetase and ligase
WCW_RS00375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WCW_RS00380	COG1747	RNA polymerase binding
WCW_RS00380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WCW_RS00390	COG0719	Fe-S assembly protein
WCW_RS00395	COG0396	ATPase activity
WCW_RS00400	COG0719	Fe-S assembly protein
WCW_RS00405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WCW_RS00410	COG0009	L-threonylcarbamoyladenylate synthase
WCW_RS00420	COG4791	protein targeting
WCW_RS00425	COG1987	bacterial-type flagellum assembly
WCW_RS00430	COG4790	Type iii secretion
WCW_RS00460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WCW_RS00465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WCW_RS00495	COG0653	protein targeting
WCW_RS00505	COG0688	phosphatidylethanolamine metabolic process
WCW_RS00510	COG0084	hydrolase, TatD family'
WCW_RS00525	COG1454	alcohol dehydrogenase
WCW_RS00550	COG0811	peptide transport
WCW_RS00565	COG0823	Involved in the tonB-independent uptake of proteins
WCW_RS00580	COG1705	Flagellar rod assembly protein muramidase FlgJ
WCW_RS00580	COG1388	LysM domain
WCW_RS00585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WCW_RS00600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WCW_RS00605	COG0745	RESPONSE REGULATOR receiver
WCW_RS00615	COG0697	spore germination
WCW_RS00630	COG0742	ribosomal rna small subunit methyltransferase
WCW_RS00725	COG2264	protein methyltransferase activity
WCW_RS00760	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WCW_RS00775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WCW_RS00795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WCW_RS00815	COG1217	gtp-binding protein TYPA
WCW_RS00820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
WCW_RS00825	COG2183	response to ionizing radiation
WCW_RS00830	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WCW_RS00880	COG2801	Transposase and inactivated derivatives
WCW_RS00905	COG0814	amino acid
WCW_RS00910	COG0814	amino acid
WCW_RS00920	COG0556	nucleotide-excision repair
WCW_RS00930	COG0666	response to abiotic stimulus
WCW_RS00945	COG2050	protein possibly involved in aromatic compounds catabolism
WCW_RS00960	COG0848	biopolymer transport protein
WCW_RS00965	COG0811	peptide transport
WCW_RS00980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WCW_RS00985	COG0343	queuine tRNA-ribosyltransferase activity
WCW_RS00990	COG1862	Preprotein translocase
WCW_RS00995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WCW_RS01020	COG4651	solute:proton antiporter activity
WCW_RS01020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WCW_RS01025	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
WCW_RS01030	COG3202	ADP transmembrane transporter activity
WCW_RS01035	COG0326	Molecular chaperone. Has ATPase activity
WCW_RS01040	COG2871	sodium ion transport
WCW_RS01045	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WCW_RS01045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WCW_RS01055	COG5433	transposase activity
WCW_RS01070	COG3335	DDE superfamily endonuclease
WCW_RS01085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
WCW_RS01090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WCW_RS01115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WCW_RS01120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WCW_RS01130	COG2824	Alkylphosphonate utilization operon protein PhnA
WCW_RS01135	COG0659	secondary active sulfate transmembrane transporter activity
WCW_RS01140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WCW_RS01145	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WCW_RS01155	COG0542	response to heat
WCW_RS01170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WCW_RS01170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WCW_RS01170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WCW_RS01175	COG0756	dUTP diphosphatase activity
WCW_RS01180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WCW_RS01185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WCW_RS01190	COG0181	hydroxymethylbilane synthase activity
WCW_RS01195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WCW_RS01200	COG0571	ribonuclease III activity
WCW_RS01250	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WCW_RS01255	COG0509	glycine decarboxylation via glycine cleavage system
WCW_RS01260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WCW_RS01265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WCW_RS01270	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WCW_RS01275	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WCW_RS01280	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WCW_RS01285	COG1805	sodium ion transport
WCW_RS01315	COG0438	transferase activity, transferring glycosyl groups
WCW_RS01320	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WCW_RS01340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WCW_RS01360	COG0601	transmembrane transport
WCW_RS01365	COG3335	DDE superfamily endonuclease
WCW_RS01370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WCW_RS01390	COG0306	phosphate transporter
WCW_RS01395	COG1392	Phosphate transport regulator
WCW_RS01400	COG0444	Belongs to the ABC transporter superfamily
WCW_RS01405	COG4608	Belongs to the ABC transporter superfamily
WCW_RS01420	COG1187	pseudouridine synthase activity
WCW_RS01425	COG0588	phosphoglycerate mutase activity
WCW_RS01435	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WCW_RS01435	COG2906	2 iron, 2 sulfur cluster binding
WCW_RS01435	COG0822	iron-sulfur transferase activity
WCW_RS01450	COG0772	Belongs to the SEDS family
WCW_RS01465	COG0051	transcription antitermination factor activity, RNA binding
WCW_RS01470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WCW_RS01475	COG0049	tRNA binding
WCW_RS01480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WCW_RS01495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WCW_RS01505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WCW_RS01510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WCW_RS01515	COG0481	GTPase activity
WCW_RS01530	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WCW_RS01535	COG0861	Integral membrane protein TerC family
WCW_RS01540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WCW_RS01545	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WCW_RS01550	COG1509	lysine 2,3-aminomutase activity
WCW_RS01585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WCW_RS01600	COG0318	PFAM AMP-dependent synthetase and ligase
WCW_RS01615	COG0284	orotidine-5'-phosphate decarboxylase activity
WCW_RS01620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WCW_RS01630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WCW_RS01635	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
WCW_RS01640	COG0540	Belongs to the ATCase OTCase family
WCW_RS01655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WCW_RS01685	COG0275	rRNA processing
WCW_RS01700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WCW_RS01715	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
WCW_RS01720	COG0750	zinc metalloprotease
WCW_RS01735	COG1132	(ABC) transporter
WCW_RS01740	COG1132	(ABC) transporter
WCW_RS01755	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WCW_RS01755	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WCW_RS01790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WCW_RS01795	COG0101	tRNA pseudouridine synthase activity
WCW_RS01805	COG1408	metallophosphoesterase
WCW_RS01825	COG1114	Component of the transport system for branched-chain amino acids
WCW_RS01845	COG0217	transcriptional regulatory protein
WCW_RS01890	COG0442	prolyl-tRNA aminoacylation
WCW_RS01915	COG1025	Belongs to the peptidase M16 family
WCW_RS01930	COG1530	ribonuclease E activity
WCW_RS01945	COG0416	fatty acid biosynthetic process
WCW_RS01970	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WCW_RS01970	COG3952	Lipid A Biosynthesis
WCW_RS01975	COG0463	Glycosyl transferase, family 2
WCW_RS01995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WCW_RS02000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WCW_RS02005	COG0814	amino acid
WCW_RS02020	COG0420	3'-5' exonuclease activity
WCW_RS02025	COG0419	ATPase involved in DNA repair
WCW_RS02035	COG0552	protein localization to endoplasmic reticulum
WCW_RS02040	COG0045	succinate-CoA ligase (ADP-forming) activity
WCW_RS02045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WCW_RS02070	COG0446	pyridine nucleotide-disulphide oxidoreductase
WCW_RS02080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WCW_RS02085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WCW_RS02095	COG1301	dicarboxylic acid transport
WCW_RS02105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WCW_RS02115	COG0482	sulfurtransferase activity
WCW_RS02130	COG1028	Short-chain dehydrogenase reductase Sdr
WCW_RS02135	COG3387	PFAM Glycoside hydrolase 15-related
WCW_RS02155	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WCW_RS02175	COG1024	Enoyl-CoA hydratase
WCW_RS02180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WCW_RS02220	COG1703	isobutyryl-CoA mutase activity
WCW_RS02220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WCW_RS02220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WCW_RS02230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WCW_RS02235	COG0022	dehydrogenase e1 component
WCW_RS02245	COG3189	MarR family transcriptional regulator
WCW_RS02250	COG1017	nitric oxide dioxygenase activity
WCW_RS02250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WCW_RS02285	COG5433	transposase activity
WCW_RS02295	COG1959	2 iron, 2 sulfur cluster binding
WCW_RS02300	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
WCW_RS02330	COG0109	protoheme IX farnesyltransferase activity
WCW_RS02345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WCW_RS02350	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WCW_RS02365	COG1183	phosphatidylcholine synthase activity
WCW_RS02370	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WCW_RS02385	COG1322	Protein conserved in bacteria
WCW_RS02395	COG5433	transposase activity
WCW_RS02405	COG3266	domain, Protein
WCW_RS02420	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WCW_RS02425	COG0513	Belongs to the DEAD box helicase family
WCW_RS02435	COG2081	HI0933 family
WCW_RS02450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WCW_RS02450	COG3153	acetyltransferase
WCW_RS02460	COG1028	Short-chain dehydrogenase reductase Sdr
WCW_RS02465	COG1064	alcohol dehydrogenase
WCW_RS02470	COG3258	Cytochrome c
WCW_RS02480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
WCW_RS02485	COG0433	COG0433 Predicted ATPase
WCW_RS02490	COG0667	Aldo Keto reductase
WCW_RS02505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WCW_RS02540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WCW_RS02550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WCW_RS02555	COG0681	Belongs to the peptidase S26 family
WCW_RS02565	COG1929	Belongs to the glycerate kinase type-1 family
WCW_RS02570	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
WCW_RS02575	COG1335	isochorismatase
WCW_RS02585	COG1872	DUF167
WCW_RS02595	COG1028	Short-chain dehydrogenase reductase Sdr
WCW_RS02610	COG2801	Transposase and inactivated derivatives
WCW_RS02620	COG5433	transposase activity
WCW_RS02655	COG0488	(ABC) transporter
WCW_RS02660	COG0583	DNA-binding transcription factor activity
WCW_RS02665	COG2814	Major facilitator Superfamily
WCW_RS02670	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
WCW_RS02675	COG1253	flavin adenine dinucleotide binding
WCW_RS02690	COG0494	nUDIX hydrolase
WCW_RS02695	COG0494	nUDIX hydrolase
WCW_RS02730	COG4286	Uncharacterised protein family (UPF0160)
WCW_RS02735	COG0537	adenosine 5'-monophosphoramidase activity
WCW_RS02750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WCW_RS02765	COG0006	proline dipeptidase activity
WCW_RS02770	COG0814	amino acid
WCW_RS02780	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WCW_RS02790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WCW_RS02805	COG0250	Participates in transcription elongation, termination and antitermination
WCW_RS02810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WCW_RS02815	COG0081	regulation of translation
WCW_RS02820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WCW_RS02825	COG0222	ribosome binding
WCW_RS02830	COG0085	RNA polymerase activity
WCW_RS02835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WCW_RS02845	COG3202	ADP transmembrane transporter activity
WCW_RS02850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WCW_RS02885	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
WCW_RS02895	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
WCW_RS02900	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
WCW_RS02905	COG1394	ATPase activity, coupled to movement of substances
WCW_RS02910	COG1269	ATP hydrolysis coupled proton transport
WCW_RS02935	COG1222	aaa ATPase
WCW_RS02955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
WCW_RS02990	COG2801	Transposase and inactivated derivatives
WCW_RS03000	COG2801	Transposase and inactivated derivatives
WCW_RS03060	COG1028	Short-chain dehydrogenase reductase Sdr
WCW_RS03075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WCW_RS03115	COG1830	Aldolase
WCW_RS03130	COG0519	Catalyzes the synthesis of GMP from XMP
WCW_RS03155	COG2801	Transposase and inactivated derivatives
WCW_RS03180	COG3335	DDE superfamily endonuclease
WCW_RS03205	COG0305	Participates in initiation and elongation during chromosome replication
WCW_RS03265	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
WCW_RS03270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WCW_RS03295	COG0037	tRNA processing
WCW_RS03300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WCW_RS03310	COG1185	polyribonucleotide nucleotidyltransferase activity
WCW_RS03315	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WCW_RS03325	COG0590	tRNA wobble adenosine to inosine editing
WCW_RS03345	COG0254	rRNA binding
WCW_RS03350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WCW_RS03355	COG2890	protein-(glutamine-N5) methyltransferase activity
WCW_RS03360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WCW_RS03365	COG0228	four-way junction DNA binding
WCW_RS03370	COG0336	Belongs to the RNA methyltransferase TrmD family
WCW_RS03375	COG0335	large ribosomal subunit rRNA binding
WCW_RS03380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WCW_RS03400	COG1561	YicC-like family, N-terminal region
WCW_RS03405	COG0194	GDP metabolic process
WCW_RS03420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WCW_RS03420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WCW_RS03425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WCW_RS03450	COG0724	RNA recognition motif
WCW_RS03465	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WCW_RS03470	COG2224	Isocitrate lyase
WCW_RS03480	COG0024	Methionine aminopeptidase
WCW_RS03485	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WCW_RS03490	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
WCW_RS03500	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
WCW_RS03505	COG0166	Belongs to the GPI family
WCW_RS03515	COG4974	Belongs to the 'phage' integrase family
WCW_RS03530	COG0307	riboflavin synthase, alpha
WCW_RS03545	COG2067	long-chain fatty acid transport protein
WCW_RS03555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WCW_RS03560	COG0154	amidase activity
WCW_RS03565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WCW_RS03580	COG1090	epimerase
WCW_RS03620	COG0497	DNA recombination
WCW_RS03630	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WCW_RS03645	COG0101	tRNA pseudouridine synthase activity
WCW_RS03650	COG2095	MarC family integral membrane protein
WCW_RS03655	COG2095	MarC family integral membrane protein
WCW_RS03670	COG0837	glucose binding
WCW_RS03680	COG0436	Aminotransferase
WCW_RS03685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WCW_RS03690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WCW_RS03695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WCW_RS03700	COG2363	Small membrane protein
WCW_RS03710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WCW_RS03715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WCW_RS03730	COG0358	DNA primase activity
WCW_RS03765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WCW_RS03775	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
WCW_RS03780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WCW_RS03785	COG1271	oxidase subunit
WCW_RS03790	COG1294	oxidase, subunit
WCW_RS03795	COG2826	transposase and inactivated derivatives, IS30 family
WCW_RS03810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WCW_RS03820	COG0587	DNA-directed DNA polymerase activity
WCW_RS03825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WCW_RS03830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WCW_RS03840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WCW_RS03845	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
WCW_RS03850	COG2252	PERMEase
WCW_RS03870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WCW_RS03875	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WCW_RS03880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WCW_RS03890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WCW_RS03900	COG1115	amino acid carrier protein
WCW_RS03905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WCW_RS03925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WCW_RS03930	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WCW_RS03935	COG0193	aminoacyl-tRNA hydrolase activity
WCW_RS03940	COG0360	Binds together with S18 to 16S ribosomal RNA
WCW_RS03945	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WCW_RS03950	COG0359	binds to the 23S rRNA
WCW_RS03960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WCW_RS03960	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WCW_RS03975	COG2801	Transposase and inactivated derivatives
WCW_RS03995	COG0277	FAD linked oxidase domain protein
WCW_RS03995	COG0247	lactate metabolic process
WCW_RS04000	COG3724	N-succinylarginine dihydrolase activity
WCW_RS04005	COG1012	belongs to the aldehyde dehydrogenase family
WCW_RS04010	COG3335	DDE superfamily endonuclease
WCW_RS04020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WCW_RS04060	COG0542	response to heat
WCW_RS04070	COG2096	Adenosyltransferase
WCW_RS04080	COG1640	4-alpha-glucanotransferase
WCW_RS04105	COG4789	Type iii secretion
WCW_RS04110	COG4792	protein secretion
WCW_RS04115	COG0012	GTP binding
WCW_RS04140	COG0196	riboflavin kinase activity
WCW_RS04145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WCW_RS04150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WCW_RS04155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WCW_RS04160	COG0195	Participates in both transcription termination and antitermination
WCW_RS04165	COG0539	negative regulation of cytoplasmic translation
WCW_RS04165	COG2183	response to ionizing radiation
WCW_RS04185	COG1114	Component of the transport system for branched-chain amino acids
WCW_RS04190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WCW_RS04195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WCW_RS04200	COG0511	ligase activity, forming carbon-carbon bonds
WCW_RS04205	COG0439	Biotin carboxylase
WCW_RS04225	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WCW_RS04230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WCW_RS04250	COG0431	NADPH-dependent FMN reductase
WCW_RS04255	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WCW_RS04265	COG0714	Associated with various cellular activities
WCW_RS04270	COG0037	tRNA processing
WCW_RS04275	COG0653	protein targeting
WCW_RS04295	COG4122	O-methyltransferase activity
WCW_RS04300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WCW_RS04300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WCW_RS04305	COG0492	ferredoxin-NADP+ reductase activity
WCW_RS04320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WCW_RS04350	COG1435	thymidine kinase activity
WCW_RS04355	COG0488	(ABC) transporter
WCW_RS04365	COG0617	tRNA 3'-terminal CCA addition
WCW_RS04375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WCW_RS04380	COG0628	permease
WCW_RS04410	COG0322	excinuclease ABC activity
WCW_RS04425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WCW_RS04430	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WCW_RS04435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WCW_RS04440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WCW_RS04445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WCW_RS04450	COG0564	pseudouridine synthase activity
WCW_RS04455	COG0859	PFAM glycosyl transferase family 9
WCW_RS04465	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WCW_RS04470	COG1177	transmembrane transport
WCW_RS04475	COG1176	ABC-type spermidine putrescine transport system, permease component I
WCW_RS04480	COG3842	ATPase activity
WCW_RS04485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WCW_RS04490	COG0280	phosphate acetyltransferase
WCW_RS04490	COG0857	belongs to the CobB CobQ family
WCW_RS04520	COG2226	methyltransferase
WCW_RS04525	COG0367	asparagine synthase
WCW_RS04570	COG2062	phosphohistidine phosphatase, SixA
WCW_RS04575	COG1028	Short-chain dehydrogenase reductase Sdr
WCW_RS04585	COG0631	protein serine/threonine phosphatase activity
WCW_RS04590	COG1104	cysteine desulfurase activity
WCW_RS04610	COG0494	nUDIX hydrolase
WCW_RS04635	COG1331	Highly conserved protein containing a thioredoxin domain
WCW_RS04645	COG2239	Acts as a magnesium transporter
WCW_RS04675	COG0733	neurotransmitter:sodium symporter activity
WCW_RS04680	COG2255	four-way junction helicase activity
WCW_RS04690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WCW_RS04710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WCW_RS04725	COG2089	acid synthase
WCW_RS04750	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WCW_RS04760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WCW_RS04770	COG5002	protein histidine kinase activity
WCW_RS04770	COG2205	protein histidine kinase activity
WCW_RS04770	COG0784	Response regulator, receiver
WCW_RS04785	COG0492	ferredoxin-NADP+ reductase activity
WCW_RS04795	COG1333	cytochrome c biogenesis protein
WCW_RS04795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WCW_RS04800	COG0793	Belongs to the peptidase S41A family
WCW_RS04825	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WCW_RS04830	COG0567	Dehydrogenase, E1 component
WCW_RS04835	COG0508	dehydrogenase complex catalyzes the overall conversion of
WCW_RS04840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WCW_RS04845	COG0316	Belongs to the HesB IscA family
WCW_RS04860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WCW_RS04875	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WCW_RS04880	COG0706	membrane insertase activity
WCW_RS04885	COG0515	serine threonine protein kinase
WCW_RS04885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WCW_RS04890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WCW_RS04905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WCW_RS04910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WCW_RS04915	COG0470	DNA polymerase III
WCW_RS04925	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WCW_RS04970	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WCW_RS04985	COG1575	Belongs to the MenA family. Type 1 subfamily
WCW_RS05005	COG1216	Glycosyl transferase, family 2
WCW_RS05005	COG0463	Glycosyl transferase, family 2
WCW_RS05010	COG2226	methyltransferase
WCW_RS05025	COG1418	mRNA catabolic process
WCW_RS05025	COG4942	peptidase
WCW_RS05035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WCW_RS05065	COG0557	exoribonuclease II activity
WCW_RS05070	COG0495	leucyl-tRNA aminoacylation
WCW_RS05080	COG3220	belongs to the UPF0276 family
WCW_RS05100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WCW_RS05115	COG1228	amidohydrolase
WCW_RS05120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WCW_RS05125	COG2986	histidine ammonia-lyase
WCW_RS05140	COG1881	PFAM PEBP family protein
WCW_RS05145	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WCW_RS05145	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WCW_RS05150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WCW_RS05170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WCW_RS05200	COG1519	Transferase
WCW_RS05225	COG1760	l-serine dehydratase
WCW_RS05235	COG0205	6-phosphofructokinase activity
WCW_RS05250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WCW_RS05255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WCW_RS05255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WCW_RS05265	COG1295	ribonuclease BN
WCW_RS05285	COG5433	transposase activity
WCW_RS05295	COG1598	PFAM Uncharacterised protein family UPF0150
WCW_RS05300	COG1125	glycine betaine transport
WCW_RS05300	COG0517	IMP dehydrogenase activity
WCW_RS05305	COG1174	glycine betaine transport
WCW_RS05310	COG1704	LemA family
WCW_RS05315	COG0501	Belongs to the peptidase M48B family
WCW_RS05320	COG2259	Doxx family
WCW_RS05340	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
WCW_RS05345	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WCW_RS05350	COG0504	CTP synthase activity
WCW_RS05355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WCW_RS05370	COG0189	ligase activity
WCW_RS05385	COG3425	synthase
WCW_RS05420	COG0356	it plays a direct role in the translocation of protons across the membrane
WCW_RS05425	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WCW_RS05430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WCW_RS05435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WCW_RS05440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WCW_RS05445	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WCW_RS05450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WCW_RS05455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WCW_RS05470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
WCW_RS05485	COG1187	pseudouridine synthase activity
WCW_RS05500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WCW_RS05505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WCW_RS05510	COG4591	ABC-type transport system involved in lipoprotein release permease component
WCW_RS05515	COG1136	(ABC) transporter
WCW_RS05535	COG0626	cystathionine gamma-synthase activity
WCW_RS05550	COG1063	alcohol dehydrogenase
WCW_RS05565	COG2217	Heavy metal translocating P-type atpase
WCW_RS05575	COG0242	peptide deformylase activity
WCW_RS05585	COG0149	triose-phosphate isomerase activity
WCW_RS05590	COG1570	exodeoxyribonuclease VII activity
WCW_RS05595	COG1722	exodeoxyribonuclease VII activity
WCW_RS05600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WCW_RS05610	COG2226	methyltransferase
WCW_RS05620	COG0424	maF-like protein
WCW_RS05640	COG0142	geranyltranstransferase activity
WCW_RS05660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WCW_RS05665	COG1477	protein flavinylation
WCW_RS05690	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WCW_RS05695	COG0592	DNA-directed DNA polymerase activity
WCW_RS05700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WCW_RS05705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WCW_RS05715	COG4956	integral membrane protein (PIN domain superfamily)
WCW_RS05720	COG0736	holo-[acyl-carrier-protein] synthase activity
WCW_RS05725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WCW_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
WCW_RS05735	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WCW_RS05740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WCW_RS05745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WCW_RS05760	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WCW_RS05780	COG3335	DDE superfamily endonuclease
WCW_RS05795	COG0508	dehydrogenase complex catalyzes the overall conversion of
WCW_RS05800	COG0022	dehydrogenase e1 component
WCW_RS05805	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WCW_RS05815	COG1301	dicarboxylic acid transport
WCW_RS05835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WCW_RS05845	COG4864	UPF0365 protein
WCW_RS05850	COG1030	water channel activity
WCW_RS05855	COG1030	water channel activity
WCW_RS05860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WCW_RS05865	COG0729	surface antigen
WCW_RS05880	COG0367	asparagine synthase
WCW_RS05890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WCW_RS05905	COG1678	Uncharacterized ACR, COG1678
WCW_RS05910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WCW_RS05915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WCW_RS05920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WCW_RS05930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WCW_RS05940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WCW_RS05945	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
WCW_RS05955	COG2003	Belongs to the UPF0758 family
WCW_RS05960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WCW_RS05965	COG0321	lipoyl(octanoyl) transferase activity
WCW_RS05965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
WCW_RS05975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WCW_RS05975	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WCW_RS05995	COG0039	L-malate dehydrogenase activity
WCW_RS06000	COG0602	queuosine metabolic process
WCW_RS06040	COG0563	adenylate kinase activity
WCW_RS06090	COG0123	including yeast histone deacetylase and acetoin utilization protein
WCW_RS06095	COG0471	metal ion transport
WCW_RS06100	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
WCW_RS06105	COG0531	amino acid
WCW_RS06115	COG0431	NADPH-dependent FMN reductase
WCW_RS06155	COG1024	Enoyl-CoA hydratase
WCW_RS06155	COG1250	3-hydroxyacyl-CoA dehydrogenase
WCW_RS06160	COG0183	Belongs to the thiolase family
WCW_RS06165	COG1022	Amp-dependent synthetase and ligase
WCW_RS06175	COG3335	DDE superfamily endonuclease
WCW_RS06180	COG2270	Major facilitator Superfamily
WCW_RS06200	COG0751	glycine-tRNA ligase activity
WCW_RS06200	COG0752	glycyl-tRNA synthetase alpha subunit
WCW_RS06280	COG0596	Alpha beta hydrolase
WCW_RS06290	COG1181	Belongs to the D-alanine--D-alanine ligase family
WCW_RS06300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WCW_RS06305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WCW_RS06310	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WCW_RS06335	COG0457	Tetratricopeptide repeat
WCW_RS06335	COG0515	serine threonine protein kinase
WCW_RS06360	COG0525	valine-tRNA ligase activity
WCW_RS06370	COG1115	amino acid carrier protein
WCW_RS06375	COG1115	amino acid carrier protein
WCW_RS06380	COG1320	monovalent cation:proton antiporter activity
WCW_RS06385	COG2212	antiporter activity
WCW_RS06390	COG1863	multisubunit Na H antiporter MnhE subunit
WCW_RS06395	COG0651	ATP synthesis coupled electron transport
WCW_RS06400	COG1006	Multisubunit Na H antiporter MnhC subunit
WCW_RS06405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WCW_RS06405	COG2111	Na H antiporter
WCW_RS06415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WCW_RS06435	COG1132	(ABC) transporter
WCW_RS06445	COG0825	malonyl-CoA metabolic process
WCW_RS06455	COG0776	regulation of translation
WCW_RS06460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WCW_RS06470	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WCW_RS06475	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WCW_RS06485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WCW_RS06490	COG1164	Oligoendopeptidase f
WCW_RS06495	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WCW_RS06500	COG0459	protein refolding
WCW_RS06525	COG3657	addiction module killer protein
WCW_RS06540	COG0537	adenosine 5'-monophosphoramidase activity
WCW_RS06545	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WCW_RS06570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WCW_RS06575	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WCW_RS06620	COG0215	cysteine-tRNA ligase activity
WCW_RS06625	COG0204	Acyl-transferase
WCW_RS06625	COG0318	PFAM AMP-dependent synthetase and ligase
WCW_RS06635	COG0494	nUDIX hydrolase
WCW_RS06640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WCW_RS06645	COG0799	negative regulation of ribosome biogenesis
WCW_RS06670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WCW_RS06675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WCW_RS06680	COG0629	single-stranded DNA binding
WCW_RS06695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WCW_RS06700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WCW_RS06705	COG0772	Belongs to the SEDS family
WCW_RS06710	COG1388	LysM domain
WCW_RS06710	COG3584	3D domain protein
WCW_RS06715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WCW_RS06720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WCW_RS06735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WCW_RS06745	COG0157	Belongs to the NadC ModD family
WCW_RS06750	COG0459	protein refolding
WCW_RS06760	COG4139	cobalamin transport
WCW_RS06785	COG0733	neurotransmitter:sodium symporter activity
WCW_RS06790	COG0489	protein tyrosine kinase activity
WCW_RS06795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WCW_RS06815	COG4221	oxidoreductase activity
WCW_RS06825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WCW_RS06840	COG2801	Transposase and inactivated derivatives
WCW_RS06860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WCW_RS06865	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WCW_RS06875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WCW_RS06880	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
WCW_RS06905	COG1968	undecaprenyl-diphosphatase activity
WCW_RS06910	COG1674	ftsk spoiiie
WCW_RS06915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
WCW_RS06920	COG0484	heat shock protein binding
WCW_RS06925	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WCW_RS06935	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WCW_RS06950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WCW_RS06955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WCW_RS06955	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WCW_RS06965	COG1234	tRNA 3'-trailer cleavage
WCW_RS06970	COG4974	Belongs to the 'phage' integrase family
WCW_RS06985	COG0488	(ABC) transporter
WCW_RS06995	COG0302	gtp cyclohydrolase
WCW_RS07005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WCW_RS07010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WCW_RS07015	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WCW_RS07025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WCW_RS07030	COG0740	serine-type endopeptidase activity
WCW_RS07035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WCW_RS07065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WCW_RS07080	COG0534	Mate efflux family protein
WCW_RS07090	COG0183	Belongs to the thiolase family
WCW_RS07095	COG1250	3-hydroxyacyl-CoA dehydrogenase
WCW_RS07095	COG1024	Enoyl-CoA hydratase
WCW_RS07100	COG1024	Enoyl-CoA hydratase
WCW_RS07105	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WCW_RS07110	COG0372	Belongs to the citrate synthase family
WCW_RS07115	COG2079	MmgE PrpD family protein
WCW_RS07120	COG2814	Major facilitator Superfamily
WCW_RS07130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WCW_RS07135	COG0203	ribosomal protein L17
WCW_RS07140	COG0202	RNA polymerase activity
WCW_RS07145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WCW_RS07150	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WCW_RS07160	COG0200	Binds to the 23S rRNA
WCW_RS07165	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WCW_RS07170	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WCW_RS07175	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WCW_RS07180	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WCW_RS07185	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WCW_RS07190	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WCW_RS07195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WCW_RS07200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WCW_RS07205	COG0255	Belongs to the universal ribosomal protein uL29 family
WCW_RS07210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WCW_RS07215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WCW_RS07220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WCW_RS07225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WCW_RS07230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WCW_RS07235	COG0089	rRNA binding
WCW_RS07240	COG0088	Forms part of the polypeptide exit tunnel
WCW_RS07245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WCW_RS07270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WCW_RS07275	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WCW_RS07280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WCW_RS07285	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WCW_RS07290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WCW_RS07310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WCW_RS07310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WCW_RS07320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WCW_RS07330	COG1686	Belongs to the peptidase S11 family
WCW_RS07350	COG0587	DNA-directed DNA polymerase activity
WCW_RS07365	COG0124	histidyl-tRNA synthetase
WCW_RS07370	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WCW_RS07380	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WCW_RS07385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WCW_RS07395	COG1054	Belongs to the UPF0176 family
WCW_RS07430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WCW_RS07430	COG0072	phenylalanine-tRNA ligase activity
WCW_RS07435	COG0105	UTP biosynthetic process
WCW_RS07445	COG0105	UTP biosynthetic process
WCW_RS07455	COG1137	ATPase activity
WCW_RS07465	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WCW_RS07485	COG1837	Belongs to the UPF0109 family
WCW_RS07490	COG1490	D-aminoacyl-tRNA deacylase activity
WCW_RS07530	COG1086	Polysaccharide biosynthesis protein
WCW_RS07535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WCW_RS07545	COG0017	Asparaginyl-tRNA synthetase
WCW_RS07550	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
WCW_RS07555	COG0728	peptidoglycan biosynthetic process
WCW_RS07565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WCW_RS07575	COG2204	response regulator
WCW_RS07585	COG3335	DDE superfamily endonuclease
WCW_RS07605	COG3335	DDE superfamily endonuclease
WCW_RS07635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WCW_RS07660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
WCW_RS07665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WCW_RS07665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WCW_RS07670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WCW_RS07675	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
WCW_RS07680	COG1077	Cell shape determining protein MreB Mrl
WCW_RS07685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WCW_RS07695	COG0544	peptidyl-prolyl cis-trans isomerase activity
WCW_RS07700	COG0740	serine-type endopeptidase activity
WCW_RS07705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WCW_RS07820	COG1450	Type ii and iii secretion system protein
WCW_RS07830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
WCW_RS07840	COG1160	GTP binding
WCW_RS07845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WCW_RS07850	COG0686	Belongs to the AlaDH PNT family
WCW_RS07855	COG1196	nuclear chromosome segregation
WCW_RS07860	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WCW_RS07890	COG1420	regulation of RNA biosynthetic process
WCW_RS07895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WCW_RS07900	COG0443	Heat shock 70 kDa protein
WCW_RS07915	COG1619	proteins homologs of microcin C7 resistance protein MccF
WCW_RS07930	COG0616	signal peptide processing
WCW_RS07940	COG0237	dephospho-CoA kinase activity
WCW_RS07945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WCW_RS07955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WCW_RS07960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WCW_RS07965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WCW_RS07970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WCW_RS07985	COG0138	bifunctional purine biosynthesis protein purh
WCW_RS07995	COG0149	triose-phosphate isomerase activity
WCW_RS08000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WCW_RS08000	COG0519	Catalyzes the synthesis of GMP from XMP
WCW_RS08025	COG0793	Belongs to the peptidase S41A family
WCW_RS08030	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WCW_RS08040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WCW_RS08055	COG1121	(ABC) transporter
WCW_RS08060	COG0803	Belongs to the bacterial solute-binding protein 9 family
WCW_RS08070	COG0489	protein tyrosine kinase activity
WCW_RS08080	COG3202	ADP transmembrane transporter activity
WCW_RS08085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WCW_RS08085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WCW_RS08090	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
WCW_RS08090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WCW_RS08100	COG0793	Belongs to the peptidase S41A family
WCW_RS08105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WCW_RS08120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WCW_RS08150	COG2801	Transposase and inactivated derivatives
WCW_RS08160	COG0735	belongs to the Fur family
WCW_RS08165	COG3202	ADP transmembrane transporter activity
WCW_RS08170	COG3202	ADP transmembrane transporter activity
WCW_RS08175	COG0126	phosphoglycerate kinase activity
WCW_RS08180	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
WCW_RS08185	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
WCW_RS08190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WCW_RS08195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WCW_RS08200	COG0802	atpase or kinase
WCW_RS08215	COG0018	arginyl-trna synthetase
WCW_RS08220	COG2217	Heavy metal translocating P-type atpase
WCW_RS08240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WCW_RS08255	COG0842	Transport permease protein
WCW_RS08260	COG0842	Transport permease protein
WCW_RS08265	COG1131	(ABC) transporter
WCW_RS08270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WCW_RS08305	COG0471	metal ion transport
WCW_RS08305	COG3273	potassium ion transport
WCW_RS08320	COG0517	IMP dehydrogenase activity
WCW_RS08320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WCW_RS08325	COG0473	3-isopropylmalate dehydrogenase activity
WCW_RS08330	COG1301	dicarboxylic acid transport
WCW_RS08335	COG1663	tetraacyldisaccharide 4'-kinase activity
WCW_RS08340	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WCW_RS08390	COG0564	pseudouridine synthase activity
WCW_RS08395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WCW_RS08405	COG1546	Belongs to the CinA family
WCW_RS08405	COG1058	Belongs to the CinA family
WCW_RS08420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WCW_RS08425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WCW_RS08435	COG1611	Belongs to the LOG family
WCW_RS08460	COG0483	inositol monophosphate 1-phosphatase activity
WCW_RS08465	COG4285	Biotin-protein ligase, N terminal
WCW_RS08470	COG1268	BioY protein
WCW_RS08495	COG0408	coproporphyrinogen oxidase activity
WCW_RS08500	COG0442	prolyl-tRNA aminoacylation
WCW_RS08520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WCW_RS08535	COG0305	Participates in initiation and elongation during chromosome replication
WCW_RS08540	COG0445	tRNA wobble uridine modification
WCW_RS08550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WCW_RS08570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WCW_RS08575	COG1053	succinate dehydrogenase
WCW_RS08580	COG2009	succinate dehydrogenase
WCW_RS08585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WCW_RS08590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WCW_RS08595	COG0632	four-way junction helicase activity
WCW_RS08600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WCW_RS08625	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WCW_RS08640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WCW_RS08640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WCW_RS08690	COG2801	Transposase and inactivated derivatives
WCW_RS08720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WCW_RS08725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WCW_RS08745	COG0438	transferase activity, transferring glycosyl groups
WCW_RS08765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WCW_RS08770	COG1538	Outer membrane efflux protein
WCW_RS08825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WCW_RS08840	COG1012	belongs to the aldehyde dehydrogenase family
WCW_RS08865	COG1012	belongs to the aldehyde dehydrogenase family
WCW_RS08870	COG3876	Protein conserved in bacteria
WCW_RS08875	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WCW_RS08880	COG0459	protein refolding
WCW_RS08905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WCW_RS08930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WCW_RS08935	COG0450	alkyl hydroperoxide reductase
WCW_RS08945	COG0148	phosphopyruvate hydratase activity
WCW_RS08950	COG1162	GTPase activity
WCW_RS08965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WCW_RS08970	COG0617	tRNA 3'-terminal CCA addition
WCW_RS08975	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WCW_RS08990	COG0714	Associated with various cellular activities
WCW_RS09015	COG0058	SHG alpha-glucan phosphorylase activity
WCW_RS09020	COG0366	Alpha amylase catalytic
WCW_RS09025	COG0366	Alpha amylase catalytic
WCW_RS09030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WCW_RS09050	COG2801	Transposase and inactivated derivatives
WCW_RS09070	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WCW_RS09115	COG5433	transposase activity
WCW_RS09120	COG2801	Transposase and inactivated derivatives
WCW_RS09175	COG2165	general secretion pathway protein
WCW_RS09190	COG1459	type II secretion system
WCW_RS09195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WCW_RS09220	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WCW_RS09225	COG0668	transmembrane transport
WCW_RS09235	COG0584	glycerophosphoryl diester phosphodiesterase
WCW_RS09255	COG0384	phenazine biosynthesis protein PhzF
WCW_RS09275	COG0768	penicillin binding
WCW_RS09285	COG0052	Belongs to the universal ribosomal protein uS2 family
WCW_RS09290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WCW_RS09295	COG0528	UMP kinase activity
WCW_RS09300	COG0233	cytoplasmic translational termination
WCW_RS09315	COG3880	PFAM UvrB UvrC protein
WCW_RS09320	COG3869	Catalyzes the specific phosphorylation of arginine residues in
WCW_RS09335	COG0268	Binds directly to 16S ribosomal RNA
WCW_RS09340	COG0564	pseudouridine synthase activity
WCW_RS09365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WCW_RS09370	COG1199	ATP-dependent helicase activity
WCW_RS09385	COG1640	4-alpha-glucanotransferase
WCW_RS09440	COG1254	Belongs to the acylphosphatase family
WCW_RS09450	COG0762	integral membrane protein
WCW_RS09475	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WCW_RS09630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WCW_RS09640	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
WCW_RS09645	COG0575	Belongs to the CDS family
WCW_RS09685	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
WCW_RS09695	COG0584	glycerophosphoryl diester phosphodiesterase
WCW_RS09710	COG0668	transmembrane transport
WCW_RS09730	COG1196	nuclear chromosome segregation
WCW_RS09730	COG3264	Mechanosensitive ion channel
WCW_RS09750	COG3850	Histidine kinase
WCW_RS09750	COG3437	response regulator, receiver
WCW_RS09750	COG2205	protein histidine kinase activity
WCW_RS09750	COG4999	Histidine kinase
WCW_RS09770	COG1214	PFAM Peptidase M22, glycoprotease
WCW_RS09785	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WCW_RS09785	COG1776	CheC inhibitor of MCP methylation
WCW_RS09790	COG2815	serine threonine protein kinase
WCW_RS09790	COG0515	serine threonine protein kinase
WCW_RS09830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family