locus-tag	class	description
WEEVI_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WEEVI_RS00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WEEVI_RS00015	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WEEVI_RS00035	COG0629	single-stranded DNA binding
WEEVI_RS00045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WEEVI_RS00050	COG0569	domain protein
WEEVI_RS00060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WEEVI_RS00070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WEEVI_RS00075	COG1028	Short-chain dehydrogenase reductase Sdr
WEEVI_RS00080	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WEEVI_RS00095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WEEVI_RS00100	COG1216	Glycosyl transferase, family 2
WEEVI_RS00100	COG0463	Glycosyl transferase, family 2
WEEVI_RS00125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WEEVI_RS00130	COG3001	Fructosamine kinase
WEEVI_RS00165	COG0431	NADPH-dependent FMN reductase
WEEVI_RS00170	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WEEVI_RS00175	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WEEVI_RS00175	COG1918	ferrous iron import across plasma membrane
WEEVI_RS00185	COG1301	dicarboxylic acid transport
WEEVI_RS00270	COG2217	Heavy metal translocating P-type atpase
WEEVI_RS00355	COG0129	dihydroxy-acid dehydratase activity
WEEVI_RS00360	COG0028	Belongs to the TPP enzyme family
WEEVI_RS00365	COG0440	acetolactate synthase activity
WEEVI_RS00370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WEEVI_RS00375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WEEVI_RS00405	COG3059	membrane
WEEVI_RS00425	COG4413	Urea transporter
WEEVI_RS00430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WEEVI_RS00440	COG1401	restriction endodeoxyribonuclease activity
WEEVI_RS00445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
WEEVI_RS00455	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WEEVI_RS00470	COG3392	D12 class N6 adenine-specific DNA methyltransferase
WEEVI_RS00630	COG2003	Belongs to the UPF0758 family
WEEVI_RS00745	COG1230	cation diffusion facilitator family transporter
WEEVI_RS00765	COG1002	Type II restriction enzyme, methylase subunits
WEEVI_RS00800	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WEEVI_RS00805	COG4974	Belongs to the 'phage' integrase family
WEEVI_RS00810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WEEVI_RS00815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WEEVI_RS00820	COG0569	domain protein
WEEVI_RS00855	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WEEVI_RS00880	COG2890	protein-(glutamine-N5) methyltransferase activity
WEEVI_RS00885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WEEVI_RS00895	COG1183	phosphatidylcholine synthase activity
WEEVI_RS00900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WEEVI_RS00905	COG0179	Fumarylacetoacetate (FAA) hydrolase
WEEVI_RS00915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WEEVI_RS00925	COG0450	alkyl hydroperoxide reductase
WEEVI_RS00930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WEEVI_RS00940	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WEEVI_RS00945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WEEVI_RS00945	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WEEVI_RS00960	COG3591	Belongs to the peptidase S1B family
WEEVI_RS00970	COG1012	belongs to the aldehyde dehydrogenase family
WEEVI_RS00975	COG1960	acyl-CoA dehydrogenase activity
WEEVI_RS00990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WEEVI_RS00995	COG0586	Pfam SNARE associated Golgi protein
WEEVI_RS01000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WEEVI_RS01010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WEEVI_RS01010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WEEVI_RS01015	COG1739	Uncharacterized protein family UPF0029
WEEVI_RS01025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WEEVI_RS01035	COG3185	4-Hydroxyphenylpyruvate dioxygenase
WEEVI_RS01050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WEEVI_RS01075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WEEVI_RS01125	COG1538	Outer membrane efflux protein
WEEVI_RS01440	COG0423	glycine-tRNA ligase activity
WEEVI_RS01445	COG1950	PFAM Membrane protein of
WEEVI_RS01450	COG1360	Flagellar Motor Protein
WEEVI_RS01455	COG1652	LysM domain
WEEVI_RS01465	COG0252	asparaginase activity
WEEVI_RS01475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WEEVI_RS01490	COG0666	response to abiotic stimulus
WEEVI_RS01495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WEEVI_RS01500	COG0505	Belongs to the CarA family
WEEVI_RS01505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WEEVI_RS01510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WEEVI_RS01515	COG0137	argininosuccinate synthase activity
WEEVI_RS01520	COG1438	arginine binding
WEEVI_RS01530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WEEVI_RS01655	COG2963	transposase activity
WEEVI_RS01675	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WEEVI_RS01720	COG0420	3'-5' exonuclease activity
WEEVI_RS01725	COG0419	ATPase involved in DNA repair
WEEVI_RS01730	COG0326	Molecular chaperone. Has ATPase activity
WEEVI_RS01740	COG1428	Deoxynucleoside kinase
WEEVI_RS01750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WEEVI_RS01755	COG0719	Fe-S assembly protein
WEEVI_RS01760	COG0396	ATPase activity
WEEVI_RS01765	COG0719	Fe-S assembly protein
WEEVI_RS01770	COG0316	Belongs to the HesB IscA family
WEEVI_RS01785	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WEEVI_RS01810	COG0656	L-ascorbic acid biosynthetic process
WEEVI_RS01835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WEEVI_RS01845	COG1858	cytochrome C peroxidase
WEEVI_RS01855	COG1999	signal sequence binding
WEEVI_RS01870	COG2326	polyphosphate kinase activity
WEEVI_RS01895	COG0335	large ribosomal subunit rRNA binding
WEEVI_RS01900	COG0194	GDP metabolic process
WEEVI_RS01905	COG1561	YicC-like family, N-terminal region
WEEVI_RS01910	COG1228	amidohydrolase
WEEVI_RS01915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WEEVI_RS01930	COG2195	Cleaves the N-terminal amino acid of tripeptides
WEEVI_RS01940	COG1169	isochorismate synthase
WEEVI_RS01945	COG2050	protein possibly involved in aromatic compounds catabolism
WEEVI_RS01995	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WEEVI_RS02010	COG0254	rRNA binding
WEEVI_RS02020	COG2234	aminopeptidase activity
WEEVI_RS02025	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WEEVI_RS02030	COG1960	acyl-CoA dehydrogenase activity
WEEVI_RS02035	COG0183	Belongs to the thiolase family
WEEVI_RS02040	COG1024	Enoyl-CoA hydratase
WEEVI_RS02040	COG1250	3-hydroxyacyl-CoA dehydrogenase
WEEVI_RS02045	COG1846	Transcriptional regulator
WEEVI_RS02055	COG0783	Belongs to the Dps family
WEEVI_RS02060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WEEVI_RS02085	COG0288	reversible hydration of carbon dioxide
WEEVI_RS02095	COG0592	DNA-directed DNA polymerase activity
WEEVI_RS02110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WEEVI_RS02120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WEEVI_RS02125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WEEVI_RS02130	COG0156	8-amino-7-oxononanoate synthase activity
WEEVI_RS02145	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WEEVI_RS02150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WEEVI_RS02165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WEEVI_RS02170	COG2255	four-way junction helicase activity
WEEVI_RS02175	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WEEVI_RS02185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WEEVI_RS02190	COG0181	hydroxymethylbilane synthase activity
WEEVI_RS02200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WEEVI_RS02215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WEEVI_RS02240	COG0386	Belongs to the glutathione peroxidase family
WEEVI_RS02245	COG1333	cytochrome c biogenesis protein
WEEVI_RS02245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WEEVI_RS02250	COG0693	protein deglycase activity
WEEVI_RS02255	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WEEVI_RS02270	COG0463	Glycosyl transferase, family 2
WEEVI_RS02295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
WEEVI_RS02300	COG1012	belongs to the aldehyde dehydrogenase family
WEEVI_RS02345	COG1506	peptidase
WEEVI_RS02345	COG0823	Involved in the tonB-independent uptake of proteins
WEEVI_RS02365	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
WEEVI_RS02370	COG0730	response to heat
WEEVI_RS02380	COG0288	reversible hydration of carbon dioxide
WEEVI_RS02385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WEEVI_RS02390	COG1053	succinate dehydrogenase
WEEVI_RS02440	COG0508	dehydrogenase complex catalyzes the overall conversion of
WEEVI_RS02450	COG3852	Histidine kinase
WEEVI_RS02455	COG2239	Acts as a magnesium transporter
WEEVI_RS02460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WEEVI_RS02465	COG2177	Part of the ABC transporter FtsEX involved in
WEEVI_RS02475	COG1968	undecaprenyl-diphosphatase activity
WEEVI_RS02480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WEEVI_RS02495	COG0427	acetyl-CoA hydrolase
WEEVI_RS02510	COG0754	glutathionylspermidine amidase activity
WEEVI_RS02515	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WEEVI_RS02520	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WEEVI_RS02525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WEEVI_RS02530	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WEEVI_RS02535	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WEEVI_RS02535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WEEVI_RS02540	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WEEVI_RS02545	COG1078	dGTPase activity
WEEVI_RS02550	COG2204	response regulator
WEEVI_RS02555	COG0802	atpase or kinase
WEEVI_RS02560	COG0686	Belongs to the AlaDH PNT family
WEEVI_RS02570	COG3040	lipid binding
WEEVI_RS02575	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WEEVI_RS02580	COG1181	Belongs to the D-alanine--D-alanine ligase family
WEEVI_RS02590	COG0564	pseudouridine synthase activity
WEEVI_RS02595	COG1546	Belongs to the CinA family
WEEVI_RS02595	COG1058	Belongs to the CinA family
WEEVI_RS02600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WEEVI_RS02610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WEEVI_RS02630	COG1074	ATP-dependent DNA helicase activity
WEEVI_RS02635	COG0322	excinuclease ABC activity
WEEVI_RS02650	COG4771	TonB-dependent receptor
WEEVI_RS02660	COG4771	TonB-dependent receptor
WEEVI_RS02665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WEEVI_RS02670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WEEVI_RS02680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WEEVI_RS02690	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WEEVI_RS02695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WEEVI_RS02695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WEEVI_RS02700	COG0799	negative regulation of ribosome biogenesis
WEEVI_RS02705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WEEVI_RS02715	COG4589	Belongs to the CDS family
WEEVI_RS02720	COG0688	phosphatidylethanolamine metabolic process
WEEVI_RS02735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WEEVI_RS02740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WEEVI_RS02760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WEEVI_RS02785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WEEVI_RS02805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WEEVI_RS02810	COG3829	transcription factor binding
WEEVI_RS02835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WEEVI_RS02840	COG0459	protein refolding
WEEVI_RS02845	COG0579	oxidoreductase
WEEVI_RS02850	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WEEVI_RS02865	COG0438	transferase activity, transferring glycosyl groups
WEEVI_RS02870	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WEEVI_RS02870	COG0463	Glycosyl transferase, family 2
WEEVI_RS02875	COG0438	transferase activity, transferring glycosyl groups
WEEVI_RS02895	COG1136	(ABC) transporter
WEEVI_RS02900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WEEVI_RS02905	COG0612	Peptidase, M16
WEEVI_RS02910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WEEVI_RS02920	COG0463	Glycosyl transferase, family 2
WEEVI_RS02930	COG0504	CTP synthase activity
WEEVI_RS02935	COG0706	membrane insertase activity
WEEVI_RS02945	COG1862	Preprotein translocase
WEEVI_RS02955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WEEVI_RS02960	COG1132	(ABC) transporter
WEEVI_RS02970	COG2261	transglycosylase associated protein
WEEVI_RS02975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WEEVI_RS02990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WEEVI_RS02995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WEEVI_RS03000	COG0489	protein tyrosine kinase activity
WEEVI_RS03015	COG1215	transferase activity, transferring glycosyl groups
WEEVI_RS03025	COG1216	Glycosyl transferase, family 2
WEEVI_RS03025	COG1442	glycosyl transferase family 8
WEEVI_RS03030	COG0438	transferase activity, transferring glycosyl groups
WEEVI_RS03050	COG1028	Short-chain dehydrogenase reductase Sdr
WEEVI_RS03060	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WEEVI_RS03070	COG1216	Glycosyl transferase, family 2
WEEVI_RS03080	COG1216	Glycosyl transferase, family 2
WEEVI_RS03090	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WEEVI_RS03125	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WEEVI_RS03130	COG0564	pseudouridine synthase activity
WEEVI_RS03145	COG1335	isochorismatase
WEEVI_RS03160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WEEVI_RS03165	COG2226	methyltransferase
WEEVI_RS03180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WEEVI_RS03195	COG0805	protein transport
WEEVI_RS03205	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
WEEVI_RS03215	COG2211	Major facilitator Superfamily
WEEVI_RS03220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
WEEVI_RS03230	COG0105	UTP biosynthetic process
WEEVI_RS03235	COG4771	TonB-dependent receptor
WEEVI_RS03245	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WEEVI_RS03250	COG0424	maF-like protein
WEEVI_RS03255	COG0428	transporter
WEEVI_RS03265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WEEVI_RS03270	COG0167	dihydroorotate dehydrogenase activity
WEEVI_RS03290	COG0542	response to heat
WEEVI_RS03295	COG1388	LysM domain
WEEVI_RS03295	COG3942	CHAP domain
WEEVI_RS03300	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
WEEVI_RS03305	COG0584	glycerophosphoryl diester phosphodiesterase
WEEVI_RS03320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WEEVI_RS03345	COG2963	transposase activity
WEEVI_RS03355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WEEVI_RS03370	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WEEVI_RS03420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WEEVI_RS03430	COG0045	succinate-CoA ligase (ADP-forming) activity
WEEVI_RS03450	COG1610	YqeY-like protein
WEEVI_RS03455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WEEVI_RS03470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WEEVI_RS03475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WEEVI_RS03485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WEEVI_RS03490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WEEVI_RS03495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WEEVI_RS03500	COG0768	penicillin binding
WEEVI_RS03510	COG0275	rRNA processing
WEEVI_RS03515	COG2001	Belongs to the MraZ family
WEEVI_RS03525	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WEEVI_RS03530	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WEEVI_RS03540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WEEVI_RS03545	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
WEEVI_RS03550	COG3720	iron ion transport
WEEVI_RS03570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WEEVI_RS03590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WEEVI_RS03595	COG1970	mechanosensitive ion channel activity
WEEVI_RS03610	COG0442	prolyl-tRNA aminoacylation
WEEVI_RS03620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WEEVI_RS03640	COG0508	dehydrogenase complex catalyzes the overall conversion of
WEEVI_RS03650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WEEVI_RS03655	COG0085	RNA polymerase activity
WEEVI_RS03660	COG0222	ribosome binding
WEEVI_RS03665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WEEVI_RS03670	COG0081	regulation of translation
WEEVI_RS03675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WEEVI_RS03695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WEEVI_RS03725	COG4974	Belongs to the 'phage' integrase family
WEEVI_RS03730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WEEVI_RS03735	COG1960	acyl-CoA dehydrogenase activity
WEEVI_RS03740	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
WEEVI_RS03745	COG1012	belongs to the aldehyde dehydrogenase family
WEEVI_RS03760	COG0022	dehydrogenase e1 component
WEEVI_RS03795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WEEVI_RS03800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WEEVI_RS03815	COG0268	Binds directly to 16S ribosomal RNA
WEEVI_RS03820	COG0791	NLP P60 protein
WEEVI_RS03845	COG1611	Belongs to the LOG family
WEEVI_RS03865	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WEEVI_RS03870	COG0545	Peptidyl-prolyl cis-trans isomerase
WEEVI_RS03880	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WEEVI_RS03885	COG1674	ftsk spoiiie
WEEVI_RS03895	COG0795	lipopolysaccharide-transporting ATPase activity
WEEVI_RS03900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WEEVI_RS03900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WEEVI_RS03905	COG0708	Exodeoxyribonuclease III
WEEVI_RS03910	COG3047	cAMP biosynthetic process
WEEVI_RS03910	COG2885	chlorophyll binding
WEEVI_RS03925	COG0494	nUDIX hydrolase
WEEVI_RS03930	COG4974	Belongs to the 'phage' integrase family
WEEVI_RS03935	COG0793	Belongs to the peptidase S41A family
WEEVI_RS03960	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WEEVI_RS03970	COG0742	ribosomal rna small subunit methyltransferase
WEEVI_RS03985	COG0539	negative regulation of cytoplasmic translation
WEEVI_RS03990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WEEVI_RS04050	COG1506	peptidase
WEEVI_RS04050	COG0823	Involved in the tonB-independent uptake of proteins
WEEVI_RS04055	COG3104	oligopeptide transport
WEEVI_RS04060	COG3104	oligopeptide transport
WEEVI_RS04075	COG2333	competence protein COMEC
WEEVI_RS04075	COG0658	competence protein
WEEVI_RS04100	COG4464	protein tyrosine phosphatase activity
WEEVI_RS04105	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WEEVI_RS04125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WEEVI_RS04130	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WEEVI_RS04135	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WEEVI_RS04140	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WEEVI_RS04145	COG0649	NAD binding
WEEVI_RS04150	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WEEVI_RS04155	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WEEVI_RS04160	COG1034	ATP synthesis coupled electron transport
WEEVI_RS04165	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WEEVI_RS04170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WEEVI_RS04180	COG0713	ATP synthesis coupled electron transport
WEEVI_RS04185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WEEVI_RS04190	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WEEVI_RS04195	COG1007	ATP synthesis coupled electron transport
WEEVI_RS04205	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
WEEVI_RS04210	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WEEVI_RS04215	COG3384	dioxygenase
WEEVI_RS04225	COG0509	glycine decarboxylation via glycine cleavage system
WEEVI_RS04235	COG0632	four-way junction helicase activity
WEEVI_RS04250	COG0348	domain, Protein
WEEVI_RS04275	COG2217	Heavy metal translocating P-type atpase
WEEVI_RS04295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WEEVI_RS04305	COG1418	mRNA catabolic process
WEEVI_RS04315	COG0228	four-way junction DNA binding
WEEVI_RS04320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WEEVI_RS04330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WEEVI_RS04340	COG2003	Belongs to the UPF0758 family
WEEVI_RS04355	COG0546	phosphoglycolate phosphatase activity
WEEVI_RS04370	COG0328	RNA-DNA hybrid ribonuclease activity
WEEVI_RS04390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WEEVI_RS04395	COG1703	isobutyryl-CoA mutase activity
WEEVI_RS04405	COG1012	belongs to the aldehyde dehydrogenase family
WEEVI_RS04485	COG3263	regulation of cellular component size
WEEVI_RS04510	COG0196	riboflavin kinase activity
WEEVI_RS04515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WEEVI_RS04520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WEEVI_RS04525	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WEEVI_RS04530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WEEVI_RS04540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WEEVI_RS04545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WEEVI_RS04550	COG1774	PSP1 C-terminal conserved region
WEEVI_RS04565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WEEVI_RS04570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WEEVI_RS04580	COG0157	Belongs to the NadC ModD family
WEEVI_RS04590	COG1619	proteins homologs of microcin C7 resistance protein MccF
WEEVI_RS04595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WEEVI_RS04600	COG0792	nuclease activity
WEEVI_RS04605	COG0586	Pfam SNARE associated Golgi protein
WEEVI_RS04610	COG0586	Pfam SNARE associated Golgi protein
WEEVI_RS04635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WEEVI_RS04645	COG0826	peptidase U32
WEEVI_RS04650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WEEVI_RS04660	COG2963	transposase activity
WEEVI_RS04675	COG1381	Involved in DNA repair and RecF pathway recombination
WEEVI_RS04685	COG0758	DNA mediated transformation
WEEVI_RS04695	COG1607	acyl-coa hydrolase
WEEVI_RS04710	COG0189	ligase activity
WEEVI_RS04720	COG0193	aminoacyl-tRNA hydrolase activity
WEEVI_RS04725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WEEVI_RS04730	COG3530	Putative quorum-sensing-regulated virulence factor
WEEVI_RS04735	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WEEVI_RS04740	COG1160	GTP binding
WEEVI_RS04750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WEEVI_RS04750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WEEVI_RS04755	COG1024	Enoyl-CoA hydratase
WEEVI_RS04765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WEEVI_RS04770	COG0512	Glutamine amidotransferase of anthranilate synthase
WEEVI_RS04775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WEEVI_RS04780	COG0134	indole-3-glycerol-phosphate synthase activity
WEEVI_RS04785	COG0135	phosphoribosylanthranilate isomerase activity
WEEVI_RS04790	COG0133	tryptophan synthase activity
WEEVI_RS04895	COG1045	serine acetyltransferase
WEEVI_RS04900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WEEVI_RS04955	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WEEVI_RS04960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WEEVI_RS04965	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WEEVI_RS04965	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WEEVI_RS04980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WEEVI_RS04990	COG0022	dehydrogenase e1 component
WEEVI_RS04990	COG0508	dehydrogenase complex catalyzes the overall conversion of
WEEVI_RS05005	COG1253	flavin adenine dinucleotide binding
WEEVI_RS05025	COG0463	Glycosyl transferase, family 2
WEEVI_RS05040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WEEVI_RS05045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WEEVI_RS05055	COG0297	glycogen (starch) synthase activity
WEEVI_RS05060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WEEVI_RS05065	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
WEEVI_RS05075	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WEEVI_RS05090	COG1040	competence protein
WEEVI_RS05095	COG0720	synthase
WEEVI_RS05150	COG1435	thymidine kinase activity
WEEVI_RS05155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WEEVI_RS05160	COG1752	Esterase of the alpha-beta hydrolase superfamily
WEEVI_RS05165	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WEEVI_RS05170	COG0445	tRNA wobble uridine modification
WEEVI_RS05185	COG2885	chlorophyll binding
WEEVI_RS05200	COG1741	Belongs to the pirin family
WEEVI_RS05205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WEEVI_RS05210	COG2166	iron-sulfur cluster assembly
WEEVI_RS05225	COG0557	exoribonuclease II activity
WEEVI_RS05230	COG0698	ribose 5-phosphate isomerase
WEEVI_RS05240	COG0126	phosphoglycerate kinase activity
WEEVI_RS05250	COG0714	Associated with various cellular activities
WEEVI_RS05270	COG2304	oxidoreductase activity
WEEVI_RS05285	COG2095	MarC family integral membrane protein
WEEVI_RS05295	COG0594	ribonuclease P activity
WEEVI_RS05310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WEEVI_RS05335	COG1113	amino acid transport
WEEVI_RS05340	COG3118	belongs to the thioredoxin family
WEEVI_RS05345	COG0481	GTPase activity
WEEVI_RS05360	COG2375	cellular response to nickel ion
WEEVI_RS05365	COG4607	ABC-type enterochelin transport system periplasmic component
WEEVI_RS05370	COG4604	ABC transporter, ATP-binding protein
WEEVI_RS05375	COG4605	iron ion homeostasis
WEEVI_RS05380	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WEEVI_RS05385	COG0470	DNA polymerase III
WEEVI_RS05425	COG0429	hydrolase of the alpha beta-hydrolase fold
WEEVI_RS05435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WEEVI_RS05440	COG0124	histidyl-tRNA synthetase
WEEVI_RS05455	COG0602	queuosine metabolic process
WEEVI_RS05460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WEEVI_RS05465	COG2081	HI0933 family
WEEVI_RS05500	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WEEVI_RS05515	COG0571	ribonuclease III activity
WEEVI_RS05520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WEEVI_RS05525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WEEVI_RS05530	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
WEEVI_RS05535	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WEEVI_RS05540	COG5000	phosphorelay sensor kinase activity
WEEVI_RS05565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WEEVI_RS05585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WEEVI_RS05605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WEEVI_RS05635	COG0159	tryptophan synthase activity
WEEVI_RS05640	COG3033	Beta-eliminating lyase
WEEVI_RS05650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WEEVI_RS05655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WEEVI_RS05660	COG0598	Magnesium transport protein CorA
WEEVI_RS05665	COG0702	epimerase
WEEVI_RS05670	COG4771	TonB-dependent receptor
WEEVI_RS05690	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
WEEVI_RS05720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WEEVI_RS05745	COG1187	pseudouridine synthase activity
WEEVI_RS05750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WEEVI_RS05755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WEEVI_RS05770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WEEVI_RS05785	COG0010	Belongs to the arginase family
WEEVI_RS05790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WEEVI_RS05795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WEEVI_RS05800	COG2137	regulation of response to DNA damage stimulus
WEEVI_RS05825	COG0489	protein tyrosine kinase activity
WEEVI_RS05830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WEEVI_RS05840	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WEEVI_RS05865	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WEEVI_RS05870	COG0527	aspartate kinase activity
WEEVI_RS05890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WEEVI_RS05900	COG0756	dUTP diphosphatase activity
WEEVI_RS05920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WEEVI_RS05930	COG0626	cystathionine gamma-synthase activity
WEEVI_RS05935	COG1506	peptidase
WEEVI_RS05940	COG1187	pseudouridine synthase activity
WEEVI_RS05950	COG0823	Involved in the tonB-independent uptake of proteins
WEEVI_RS05950	COG1506	peptidase
WEEVI_RS05955	COG1530	ribonuclease E activity
WEEVI_RS05960	COG0776	regulation of translation
WEEVI_RS05970	COG0629	single-stranded DNA binding
WEEVI_RS05990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WEEVI_RS05995	COG0450	alkyl hydroperoxide reductase
WEEVI_RS06005	COG1505	serine-type exopeptidase activity
WEEVI_RS06020	COG2151	metal-sulfur cluster biosynthetic enzyme
WEEVI_RS06035	COG0745	RESPONSE REGULATOR receiver
WEEVI_RS06040	COG5002	protein histidine kinase activity
WEEVI_RS06050	COG0495	leucyl-tRNA aminoacylation
WEEVI_RS06085	COG1250	3-hydroxyacyl-CoA dehydrogenase
WEEVI_RS06090	COG0673	inositol 2-dehydrogenase activity
WEEVI_RS06095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WEEVI_RS06115	COG2986	histidine ammonia-lyase
WEEVI_RS06120	COG0302	gtp cyclohydrolase
WEEVI_RS06125	COG0215	cysteine-tRNA ligase activity
WEEVI_RS06130	COG1629	transport
WEEVI_RS06170	COG0356	it plays a direct role in the translocation of protons across the membrane
WEEVI_RS06175	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WEEVI_RS06180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WEEVI_RS06185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WEEVI_RS06190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WEEVI_RS06195	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WEEVI_RS06210	COG4206	TonB-dependent receptor
WEEVI_RS06220	COG0488	(ABC) transporter
WEEVI_RS06250	COG0436	Aminotransferase
WEEVI_RS06310	COG0492	ferredoxin-NADP+ reductase activity
WEEVI_RS06320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WEEVI_RS06320	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WEEVI_RS06335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WEEVI_RS06340	COG1127	ABC transporter
WEEVI_RS06355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WEEVI_RS06370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WEEVI_RS06385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WEEVI_RS06390	COG0488	(ABC) transporter
WEEVI_RS06395	COG0284	orotidine-5'-phosphate decarboxylase activity
WEEVI_RS06395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WEEVI_RS06405	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WEEVI_RS06410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WEEVI_RS06435	COG0357	Ribosomal RNA small subunit methyltransferase G
WEEVI_RS06440	COG0187	DNA topoisomerase II activity
WEEVI_RS06450	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WEEVI_RS06460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WEEVI_RS06480	COG0668	transmembrane transport
WEEVI_RS06490	COG0343	queuine tRNA-ribosyltransferase activity
WEEVI_RS06500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WEEVI_RS06505	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WEEVI_RS06510	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WEEVI_RS06515	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WEEVI_RS06545	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WEEVI_RS06545	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WEEVI_RS06555	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WEEVI_RS06565	COG2733	membrane
WEEVI_RS06575	COG0463	Glycosyl transferase, family 2
WEEVI_RS06590	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
WEEVI_RS06590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WEEVI_RS06595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WEEVI_RS06605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WEEVI_RS06620	COG0673	inositol 2-dehydrogenase activity
WEEVI_RS06625	COG1607	acyl-coa hydrolase
WEEVI_RS06630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WEEVI_RS06670	COG3842	ATPase activity
WEEVI_RS06680	COG0596	Alpha beta hydrolase
WEEVI_RS06685	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WEEVI_RS06690	COG0668	transmembrane transport
WEEVI_RS06700	COG0779	Required for maturation of 30S ribosomal subunits
WEEVI_RS06705	COG0195	Participates in both transcription termination and antitermination
WEEVI_RS06710	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WEEVI_RS06715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WEEVI_RS06725	COG0285	dihydrofolate synthase activity
WEEVI_RS06730	COG0542	response to heat
WEEVI_RS06745	COG1045	serine acetyltransferase
WEEVI_RS06755	COG1132	(ABC) transporter
WEEVI_RS06775	COG1490	D-aminoacyl-tRNA deacylase activity
WEEVI_RS06780	COG1162	GTPase activity
WEEVI_RS06785	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WEEVI_RS06790	COG1131	(ABC) transporter
WEEVI_RS06795	COG0012	GTP binding
WEEVI_RS06840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WEEVI_RS06845	COG0739	heme binding
WEEVI_RS06850	COG4978	Transcriptional regulator
WEEVI_RS06850	COG0789	Transcriptional regulator
WEEVI_RS06860	COG3118	belongs to the thioredoxin family
WEEVI_RS06880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WEEVI_RS06885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WEEVI_RS06895	COG0321	lipoyl(octanoyl) transferase activity
WEEVI_RS06895	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
WEEVI_RS06930	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WEEVI_RS06950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WEEVI_RS06955	COG0793	Belongs to the peptidase S41A family
WEEVI_RS06960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WEEVI_RS06970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WEEVI_RS06975	COG2884	Cell division ATP-binding protein ftsE
WEEVI_RS06990	COG0438	transferase activity, transferring glycosyl groups
WEEVI_RS06995	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WEEVI_RS07000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WEEVI_RS07005	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
WEEVI_RS07010	COG0563	adenylate kinase activity
WEEVI_RS07050	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WEEVI_RS07055	COG0049	tRNA binding
WEEVI_RS07060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WEEVI_RS07065	COG0051	transcription antitermination factor activity, RNA binding
WEEVI_RS07070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WEEVI_RS07075	COG0088	Forms part of the polypeptide exit tunnel
WEEVI_RS07080	COG0089	rRNA binding
WEEVI_RS07085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WEEVI_RS07090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WEEVI_RS07095	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WEEVI_RS07100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WEEVI_RS07105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WEEVI_RS07115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WEEVI_RS07120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WEEVI_RS07130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WEEVI_RS07135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WEEVI_RS07140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WEEVI_RS07145	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WEEVI_RS07150	COG0351	phosphomethylpyrimidine kinase
WEEVI_RS07160	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
WEEVI_RS07165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WEEVI_RS07170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WEEVI_RS07175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WEEVI_RS07180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WEEVI_RS07185	COG1841	ribosomal large subunit assembly
WEEVI_RS07190	COG0200	Binds to the 23S rRNA
WEEVI_RS07195	COG0201	protein transport
WEEVI_RS07200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WEEVI_RS07205	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WEEVI_RS07210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WEEVI_RS07215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WEEVI_RS07220	COG0202	RNA polymerase activity
WEEVI_RS07225	COG0203	ribosomal protein L17
WEEVI_RS07265	COG0443	Heat shock 70 kDa protein
WEEVI_RS07280	COG0516	GMP reductase activity
WEEVI_RS07280	COG0517	IMP dehydrogenase activity
WEEVI_RS07305	COG3842	ATPase activity
WEEVI_RS07315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WEEVI_RS07325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WEEVI_RS07345	COG0300	oxidoreductase activity
WEEVI_RS07355	COG0697	spore germination
WEEVI_RS07360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WEEVI_RS07365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WEEVI_RS07385	COG0433	COG0433 Predicted ATPase
WEEVI_RS07390	COG0322	excinuclease ABC activity
WEEVI_RS07395	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WEEVI_RS07420	COG2181	nitrate reductase activity
WEEVI_RS07420	COG0247	lactate metabolic process
WEEVI_RS07425	COG2181	nitrate reductase activity
WEEVI_RS07425	COG0247	lactate metabolic process
WEEVI_RS07435	COG0860	N-Acetylmuramoyl-L-alanine amidase
WEEVI_RS07455	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WEEVI_RS07465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WEEVI_RS07470	COG0511	ligase activity, forming carbon-carbon bonds
WEEVI_RS07475	COG0439	Biotin carboxylase
WEEVI_RS07480	COG0544	peptidyl-prolyl cis-trans isomerase activity
WEEVI_RS07490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WEEVI_RS07505	COG0772	Belongs to the SEDS family
WEEVI_RS07510	COG0768	penicillin binding
WEEVI_RS07525	COG1077	Cell shape determining protein MreB Mrl
WEEVI_RS07530	COG0616	signal peptide processing
WEEVI_RS07535	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WEEVI_RS07535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WEEVI_RS07550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WEEVI_RS07560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WEEVI_RS07570	COG0791	NLP P60 protein
WEEVI_RS07575	COG0339	signal peptide processing
WEEVI_RS07585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WEEVI_RS07590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WEEVI_RS07595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WEEVI_RS07600	COG0552	protein localization to endoplasmic reticulum
WEEVI_RS07625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WEEVI_RS07640	COG1981	membrane
WEEVI_RS07650	COG1702	phosphate starvation-inducible protein PhoH
WEEVI_RS07655	COG0606	chelatase, subunit chli
WEEVI_RS07665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WEEVI_RS07705	COG1595	DNA-templated transcription, initiation
WEEVI_RS07720	COG2264	protein methyltransferase activity
WEEVI_RS07725	COG0149	triose-phosphate isomerase activity
WEEVI_RS07730	COG0601	transmembrane transport
WEEVI_RS07745	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WEEVI_RS07755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WEEVI_RS07760	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WEEVI_RS07760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WEEVI_RS07765	COG2816	NAD+ diphosphatase activity
WEEVI_RS07785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WEEVI_RS07795	COG0148	phosphopyruvate hydratase activity
WEEVI_RS07810	COG0628	permease
WEEVI_RS07820	COG4152	abc transporter atp-binding protein
WEEVI_RS07845	COG0018	arginyl-trna synthetase
WEEVI_RS07855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WEEVI_RS07865	COG2195	Cleaves the N-terminal amino acid of tripeptides
WEEVI_RS07870	COG1595	DNA-templated transcription, initiation
WEEVI_RS07880	COG0205	6-phosphofructokinase activity
WEEVI_RS07890	COG1363	Peptidase, m42
WEEVI_RS07895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WEEVI_RS07905	COG0151	Belongs to the GarS family
WEEVI_RS07915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WEEVI_RS07920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WEEVI_RS07925	COG0052	Belongs to the universal ribosomal protein uS2 family
WEEVI_RS07930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WEEVI_RS07945	COG1132	(ABC) transporter
WEEVI_RS07950	COG0101	tRNA pseudouridine synthase activity
WEEVI_RS07965	COG2986	histidine ammonia-lyase
WEEVI_RS07970	COG1028	Short-chain dehydrogenase reductase Sdr
WEEVI_RS07975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WEEVI_RS07980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WEEVI_RS07995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WEEVI_RS08020	COG1131	(ABC) transporter
WEEVI_RS08035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WEEVI_RS08045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WEEVI_RS08050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WEEVI_RS08080	COG1216	Glycosyl transferase, family 2
WEEVI_RS08090	COG0644	oxidoreductase
WEEVI_RS08110	COG0482	sulfurtransferase activity
WEEVI_RS08130	COG0006	proline dipeptidase activity
WEEVI_RS08135	COG0360	Binds together with S18 to 16S ribosomal RNA
WEEVI_RS08140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WEEVI_RS08145	COG0359	binds to the 23S rRNA
WEEVI_RS08155	COG1234	tRNA 3'-trailer cleavage
WEEVI_RS08160	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WEEVI_RS08170	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WEEVI_RS08175	COG1295	ribonuclease BN
WEEVI_RS08180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WEEVI_RS08185	COG1090	epimerase
WEEVI_RS08210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WEEVI_RS08215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WEEVI_RS08225	COG0534	Mate efflux family protein
WEEVI_RS08235	COG1131	(ABC) transporter
WEEVI_RS08245	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WEEVI_RS08255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WEEVI_RS08275	COG0217	transcriptional regulatory protein
WEEVI_RS08290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WEEVI_RS08310	COG1597	lipid kinase activity
WEEVI_RS08315	COG1368	sulfuric ester hydrolase activity
WEEVI_RS08320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WEEVI_RS08320	COG0047	phosphoribosylformylglycinamidine synthase activity
WEEVI_RS08330	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WEEVI_RS08335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WEEVI_RS08340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WEEVI_RS08345	COG0009	L-threonylcarbamoyladenylate synthase
WEEVI_RS08350	COG3022	response to hydroperoxide
WEEVI_RS08370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WEEVI_RS08370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WEEVI_RS08375	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WEEVI_RS08375	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WEEVI_RS08380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WEEVI_RS08380	COG0140	phosphoribosyl-ATP diphosphatase activity
WEEVI_RS08390	COG3011	Protein conserved in bacteria
WEEVI_RS08425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WEEVI_RS08440	COG2204	response regulator
WEEVI_RS08470	COG1678	Uncharacterized ACR, COG1678
WEEVI_RS08475	COG0259	pyridoxamine-phosphate oxidase activity
WEEVI_RS08480	COG0776	regulation of translation
WEEVI_RS08485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WEEVI_RS08490	COG0514	ATP-dependent DNA helicase (RecQ)
WEEVI_RS08495	COG1770	oligopeptidase
WEEVI_RS08505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WEEVI_RS08510	COG0561	phosphatase activity
WEEVI_RS08515	COG0861	Integral membrane protein TerC family
WEEVI_RS08530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WEEVI_RS08540	COG0564	pseudouridine synthase activity
WEEVI_RS08545	COG0037	tRNA processing
WEEVI_RS08555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WEEVI_RS08555	COG0519	Catalyzes the synthesis of GMP from XMP
WEEVI_RS08575	COG1595	DNA-templated transcription, initiation
WEEVI_RS08580	COG0791	NLP P60 protein
WEEVI_RS08600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WEEVI_RS08605	COG0531	amino acid
WEEVI_RS08610	COG2234	aminopeptidase activity
WEEVI_RS08615	COG3340	Belongs to the peptidase S51 family
WEEVI_RS08620	COG2824	Alkylphosphonate utilization operon protein PhnA
WEEVI_RS08650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WEEVI_RS08660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WEEVI_RS08675	COG0653	protein targeting
WEEVI_RS08700	COG0436	Aminotransferase
WEEVI_RS08705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WEEVI_RS08710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WEEVI_RS08715	COG1663	tetraacyldisaccharide 4'-kinase activity
WEEVI_RS08720	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
WEEVI_RS08725	COG0069	glutamate synthase activity
WEEVI_RS08730	COG0747	negative chemotaxis
WEEVI_RS08735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WEEVI_RS08770	COG1472	Belongs to the glycosyl hydrolase 3 family
WEEVI_RS08775	COG0438	transferase activity, transferring glycosyl groups
WEEVI_RS08780	COG3186	Phenylalanine-4-hydroxylase
WEEVI_RS08785	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WEEVI_RS08790	COG3876	Protein conserved in bacteria
WEEVI_RS08805	COG1137	ATPase activity
WEEVI_RS08810	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
WEEVI_RS08825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WEEVI_RS08865	COG0494	nUDIX hydrolase
WEEVI_RS08900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WEEVI_RS08910	COG1522	sequence-specific DNA binding
WEEVI_RS08925	COG1760	l-serine dehydratase
WEEVI_RS08940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WEEVI_RS08950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WEEVI_RS08950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WEEVI_RS08965	COG0612	Peptidase, M16
WEEVI_RS08985	COG0437	4 iron, 4 sulfur cluster binding
WEEVI_RS09030	COG0242	peptide deformylase activity
WEEVI_RS09035	COG2259	Doxx family
WEEVI_RS09050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WEEVI_RS09060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WEEVI_RS09075	COG3023	N-Acetylmuramoyl-L-alanine amidase
WEEVI_RS09105	COG2356	endonuclease I
WEEVI_RS09110	COG1649	PFAM Uncharacterised BCR, COG1649
WEEVI_RS09155	COG1741	Belongs to the pirin family
WEEVI_RS09160	COG2217	Heavy metal translocating P-type atpase
WEEVI_RS09170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WEEVI_RS09175	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WEEVI_RS09200	COG1960	acyl-CoA dehydrogenase activity
WEEVI_RS09210	COG2226	methyltransferase
WEEVI_RS09220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WEEVI_RS09225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WEEVI_RS09240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WEEVI_RS09245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WEEVI_RS09245	COG4651	solute:proton antiporter activity
WEEVI_RS09255	COG0492	ferredoxin-NADP+ reductase activity
WEEVI_RS09280	COG1185	polyribonucleotide nucleotidyltransferase activity
WEEVI_RS09285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WEEVI_RS09290	COG0488	(ABC) transporter
WEEVI_RS09300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WEEVI_RS09315	COG1289	transmembrane transporter activity
WEEVI_RS09325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WEEVI_RS09325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WEEVI_RS09335	COG0572	uridine kinase
WEEVI_RS09345	COG1946	Acyl-CoA thioesterase
WEEVI_RS09365	COG1022	Amp-dependent synthetase and ligase
WEEVI_RS09410	COG2814	Major facilitator Superfamily
WEEVI_RS09420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WEEVI_RS09430	COG0671	phosphoesterase, PA-phosphatase related
WEEVI_RS09435	COG1271	oxidase subunit
WEEVI_RS09460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WEEVI_RS09475	COG0300	oxidoreductase activity
WEEVI_RS09480	COG1120	ATPase activity
WEEVI_RS09485	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WEEVI_RS09500	COG4771	TonB-dependent receptor
WEEVI_RS09515	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
WEEVI_RS09530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WEEVI_RS09540	COG2135	peptidase activity
WEEVI_RS09545	COG1193	negative regulation of DNA recombination
WEEVI_RS09550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WEEVI_RS09555	COG0300	oxidoreductase activity
WEEVI_RS09575	COG4771	TonB-dependent receptor
WEEVI_RS09585	COG0525	valine-tRNA ligase activity
WEEVI_RS09590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WEEVI_RS09590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WEEVI_RS09610	COG4206	TonB-dependent receptor
WEEVI_RS09615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WEEVI_RS09640	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
WEEVI_RS09645	COG1250	3-hydroxyacyl-CoA dehydrogenase
WEEVI_RS09665	COG0484	heat shock protein binding
WEEVI_RS09670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WEEVI_RS09680	COG0739	heme binding
WEEVI_RS09695	COG1418	mRNA catabolic process
WEEVI_RS09700	COG0006	proline dipeptidase activity
WEEVI_RS09710	COG2176	DNA-directed DNA polymerase activity
WEEVI_RS09715	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WEEVI_RS09740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WEEVI_RS09745	COG1660	Displays ATPase and GTPase activities
WEEVI_RS09760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WEEVI_RS09775	COG1528	Iron-storage protein
WEEVI_RS09785	COG1607	acyl-coa hydrolase
WEEVI_RS09790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WEEVI_RS09795	COG1388	LysM domain
WEEVI_RS09795	COG1705	Flagellar rod assembly protein muramidase FlgJ
WEEVI_RS09800	COG2515	1-aminocyclopropane-1-carboxylate deaminase
WEEVI_RS09815	COG1104	cysteine desulfurase activity
WEEVI_RS09825	COG0556	nucleotide-excision repair
WEEVI_RS09830	COG3956	TIGRFAM MazG family protein
WEEVI_RS09840	COG0242	peptide deformylase activity
WEEVI_RS09845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WEEVI_RS09850	COG2171	N-acyltransferase activity
WEEVI_RS09855	COG2076	Multidrug Resistance protein
WEEVI_RS09860	COG0523	cobalamin synthesis protein
WEEVI_RS09865	COG1408	metallophosphoesterase
WEEVI_RS09870	COG0142	geranyltranstransferase activity
WEEVI_RS09880	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WEEVI_RS09885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WEEVI_RS09920	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WEEVI_RS09935	COG0482	sulfurtransferase activity
WEEVI_RS09940	COG2356	endonuclease I
WEEVI_RS09945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WEEVI_RS09960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WEEVI_RS09975	COG0183	Belongs to the thiolase family
WEEVI_RS09980	COG0825	malonyl-CoA metabolic process
WEEVI_RS09985	COG0305	Participates in initiation and elongation during chromosome replication
WEEVI_RS10000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WEEVI_RS10005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WEEVI_RS10005	COG3153	acetyltransferase
WEEVI_RS10010	COG0322	excinuclease ABC activity
WEEVI_RS10025	COG3040	lipid binding
WEEVI_RS10035	COG4771	TonB-dependent receptor
WEEVI_RS10085	COG2963	transposase activity
WEEVI_RS10090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WEEVI_RS10105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WEEVI_RS10105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WEEVI_RS10130	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
WEEVI_RS10140	COG0358	DNA primase activity
WEEVI_RS10155	COG0463	Glycosyl transferase, family 2
WEEVI_RS10160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WEEVI_RS10175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WEEVI_RS10175	COG0463	Glycosyl transferase, family 2
WEEVI_RS10190	COG0517	IMP dehydrogenase activity
WEEVI_RS10190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WEEVI_RS10190	COG0617	tRNA 3'-terminal CCA addition
WEEVI_RS10210	COG2226	methyltransferase
WEEVI_RS10230	COG0492	ferredoxin-NADP+ reductase activity
WEEVI_RS10240	COG2217	Heavy metal translocating P-type atpase
WEEVI_RS10245	COG0402	S-adenosylhomocysteine deaminase activity
WEEVI_RS10250	COG1834	amidinotransferase
WEEVI_RS10270	COG0778	Nitroreductase
WEEVI_RS10275	COG1803	Methylglyoxal synthase
WEEVI_RS10280	COG0633	Ferredoxin
WEEVI_RS10285	COG0336	Belongs to the RNA methyltransferase TrmD family
WEEVI_RS10290	COG0113	porphobilinogen synthase activity
WEEVI_RS10295	COG0596	Alpha beta hydrolase
WEEVI_RS10305	COG0564	pseudouridine synthase activity
WEEVI_RS10310	COG0497	DNA recombination
WEEVI_RS10335	COG1528	Iron-storage protein
WEEVI_RS10340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WEEVI_RS10350	COG0737	Belongs to the 5'-nucleotidase family
WEEVI_RS10355	COG1960	acyl-CoA dehydrogenase activity
WEEVI_RS10360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WEEVI_RS10365	COG3590	peptidase
WEEVI_RS10370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WEEVI_RS10375	COG3590	peptidase
WEEVI_RS10385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WEEVI_RS10395	COG1575	Belongs to the MenA family. Type 1 subfamily
WEEVI_RS10400	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WEEVI_RS10425	COG1703	isobutyryl-CoA mutase activity
WEEVI_RS10425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WEEVI_RS10425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WEEVI_RS10435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WEEVI_RS10465	COG4717	serine-type aminopeptidase activity
WEEVI_RS10470	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WEEVI_RS10475	COG0017	Asparaginyl-tRNA synthetase
WEEVI_RS10485	COG0233	cytoplasmic translational termination
WEEVI_RS10490	COG0528	UMP kinase activity
WEEVI_RS10495	COG0084	hydrolase, TatD family'
WEEVI_RS10510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WEEVI_RS10550	COG0339	signal peptide processing
WEEVI_RS10585	COG2897	thiosulfate sulfurtransferase activity
WEEVI_RS10590	COG2270	Major facilitator Superfamily
WEEVI_RS10600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WEEVI_RS10605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WEEVI_RS10610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WEEVI_RS10620	COG0484	heat shock protein binding
WEEVI_RS10625	COG1114	Component of the transport system for branched-chain amino acids
WEEVI_RS10645	COG0156	8-amino-7-oxononanoate synthase activity
WEEVI_RS10655	COG0321	lipoyl(octanoyl) transferase activity
WEEVI_RS10680	COG0667	Aldo Keto reductase
WEEVI_RS10685	COG2814	Major facilitator Superfamily
WEEVI_RS10690	COG1902	pentaerythritol trinitrate reductase activity
WEEVI_RS10695	COG1252	NADH dehydrogenase
WEEVI_RS10700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WEEVI_RS10715	COG0735	belongs to the Fur family
WEEVI_RS10725	COG1115	amino acid carrier protein
WEEVI_RS10745	COG0681	Belongs to the peptidase S26 family
WEEVI_RS10745	COG0681	Belongs to the peptidase S26 family
WEEVI_RS10750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WEEVI_RS10760	COG1475	DNA binding
WEEVI_RS10765	COG1192	Involved in chromosome partitioning
WEEVI_RS10780	COG2066	Belongs to the glutaminase family
WEEVI_RS10785	COG0545	Peptidyl-prolyl cis-trans isomerase
WEEVI_RS10800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WEEVI_RS10990	COG0642	Histidine kinase
WEEVI_RS11000	COG0739	heme binding
WEEVI_RS11010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WEEVI_RS11035	COG2807	transmembrane transport