locus-tag	class	description
WS08_RS00005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WS08_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WS08_RS00020	COG2501	S4 domain
WS08_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WS08_RS00030	COG0187	DNA topoisomerase II activity
WS08_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WS08_RS00040	COG1368	sulfuric ester hydrolase activity
WS08_RS00115	COG1737	Transcriptional regulator
WS08_RS00120	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
WS08_RS00145	COG2233	PERMEase
WS08_RS00150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WS08_RS00155	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
WS08_RS00200	COG2252	PERMEase
WS08_RS00210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WS08_RS00220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WS08_RS00225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WS08_RS00230	COG2818	Glycosylase
WS08_RS00240	COG0495	leucyl-tRNA aminoacylation
WS08_RS00250	COG2244	polysaccharide biosynthetic process
WS08_RS00260	COG0531	amino acid
WS08_RS00270	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
WS08_RS00275	COG1074	ATP-dependent DNA helicase activity
WS08_RS00280	COG1064	alcohol dehydrogenase
WS08_RS00295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WS08_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WS08_RS00305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WS08_RS00310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WS08_RS00315	COG4493	Belongs to the UPF0637 family
WS08_RS00320	COG0360	Binds together with S18 to 16S ribosomal RNA
WS08_RS00325	COG0629	single-stranded DNA binding
WS08_RS00330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WS08_RS00345	COG0745	RESPONSE REGULATOR receiver
WS08_RS00350	COG5002	protein histidine kinase activity
WS08_RS00365	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
WS08_RS00370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WS08_RS00380	COG1078	dGTPase activity
WS08_RS00385	COG0561	phosphatase activity
WS08_RS00390	COG3343	RNA polymerase activity
WS08_RS00395	COG0504	CTP synthase activity
WS08_RS00400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WS08_RS00420	COG2337	Toxic component of a toxin-antitoxin (TA) module
WS08_RS00425	COG3973	AAA domain
WS08_RS00435	COG0248	Ppx GppA phosphatase
WS08_RS00460	COG0194	GDP metabolic process
WS08_RS00480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WS08_RS00485	COG0765	amino acid transport
WS08_RS00490	COG0765	amino acid transport
WS08_RS00495	COG4166	transmembrane transport
WS08_RS00500	COG4166	transmembrane transport
WS08_RS00505	COG0601	transmembrane transport
WS08_RS00510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WS08_RS00515	COG0444	Belongs to the ABC transporter superfamily
WS08_RS00520	COG4608	Belongs to the ABC transporter superfamily
WS08_RS00530	COG0359	binds to the 23S rRNA
WS08_RS00535	COG0305	Participates in initiation and elongation during chromosome replication
WS08_RS00540	COG2814	Major facilitator Superfamily
WS08_RS00555	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WS08_RS00565	COG0492	ferredoxin-NADP+ reductase activity
WS08_RS00570	COG0588	phosphoglycerate mutase activity
WS08_RS00575	COG1134	teichoic acid transport
WS08_RS00575	COG1388	LysM domain
WS08_RS00590	COG0586	Pfam SNARE associated Golgi protein
WS08_RS00605	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WS08_RS00610	COG1077	Cell shape determining protein MreB Mrl
WS08_RS00620	COG0772	Belongs to the SEDS family
WS08_RS00625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WS08_RS00635	COG0561	phosphatase activity
WS08_RS00640	COG0577	efflux transmembrane transporter activity
WS08_RS00640	COG1136	(ABC) transporter
WS08_RS00650	COG2188	Transcriptional regulator
WS08_RS00655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WS08_RS00670	COG2252	PERMEase
WS08_RS00680	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
WS08_RS00700	COG0561	phosphatase activity
WS08_RS00705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WS08_RS00710	COG4589	Belongs to the CDS family
WS08_RS00715	COG0750	zinc metalloprotease
WS08_RS00720	COG0442	prolyl-tRNA aminoacylation
WS08_RS00725	COG2176	DNA-directed DNA polymerase activity
WS08_RS00730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WS08_RS00765	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
WS08_RS00790	COG2183	response to ionizing radiation
WS08_RS00805	COG2217	Heavy metal translocating P-type atpase
WS08_RS00930	COG3706	GGDEF domain
WS08_RS00935	COG0716	FMN binding
WS08_RS00940	COG2199	diguanylate cyclase activity
WS08_RS00965	COG1869	D-ribose catabolic process
WS08_RS00980	COG0668	transmembrane transport
WS08_RS00985	COG4975	Glucose uptake
WS08_RS00990	COG0166	Belongs to the GPI family
WS08_RS00995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WS08_RS01000	COG1302	Protein conserved in bacteria
WS08_RS01005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WS08_RS01015	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WS08_RS01020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WS08_RS01030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WS08_RS01035	COG0049	tRNA binding
WS08_RS01040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WS08_RS01045	COG0673	inositol 2-dehydrogenase activity
WS08_RS01050	COG3842	ATPase activity
WS08_RS01060	COG1177	transmembrane transport
WS08_RS01065	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WS08_RS01070	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WS08_RS01075	COG1950	PFAM Membrane protein of
WS08_RS01080	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
WS08_RS01085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WS08_RS01095	COG0492	ferredoxin-NADP+ reductase activity
WS08_RS01110	COG0149	triose-phosphate isomerase activity
WS08_RS01125	COG0557	exoribonuclease II activity
WS08_RS01130	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WS08_RS01135	COG0765	amino acid transport
WS08_RS01140	COG1126	abc transporter atp-binding protein
WS08_RS01145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WS08_RS01150	COG0280	phosphate acetyltransferase
WS08_RS01155	COG0802	atpase or kinase
WS08_RS01170	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WS08_RS01195	COG0540	Belongs to the ATCase OTCase family
WS08_RS01205	COG0505	Belongs to the CarA family
WS08_RS01210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WS08_RS01215	COG0284	orotidine-5'-phosphate decarboxylase activity
WS08_RS01220	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WS08_RS01225	COG0438	transferase activity, transferring glycosyl groups
WS08_RS01230	COG0438	transferase activity, transferring glycosyl groups
WS08_RS01240	COG1368	sulfuric ester hydrolase activity
WS08_RS01260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS08_RS01260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS08_RS01265	COG0025	NhaP-type Na H and K H
WS08_RS01270	COG0084	hydrolase, TatD family'
WS08_RS01275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
WS08_RS01280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WS08_RS01285	COG1253	flavin adenine dinucleotide binding
WS08_RS01290	COG4466	Protein conserved in bacteria
WS08_RS01295	COG2131	deaminase
WS08_RS01305	COG1316	TRANSCRIPTIONal
WS08_RS01310	COG1983	PspC domain protein
WS08_RS01315	COG1968	undecaprenyl-diphosphatase activity
WS08_RS01335	COG0193	aminoacyl-tRNA hydrolase activity
WS08_RS01340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WS08_RS01345	COG2244	polysaccharide biosynthetic process
WS08_RS01350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WS08_RS01375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WS08_RS01380	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WS08_RS01515	COG1271	oxidase subunit
WS08_RS01520	COG1294	oxidase, subunit
WS08_RS01525	COG4988	ABC transporter
WS08_RS01530	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WS08_RS01535	COG1705	Flagellar rod assembly protein muramidase FlgJ
WS08_RS01565	COG0494	nUDIX hydrolase
WS08_RS01575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WS08_RS01590	COG1388	LysM domain
WS08_RS01600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WS08_RS01605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WS08_RS01610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WS08_RS01620	COG4120	Belongs to the binding-protein-dependent transport system permease family
WS08_RS01625	COG1116	anion transmembrane transporter activity
WS08_RS01645	COG2003	Belongs to the UPF0758 family
WS08_RS01650	COG1077	Cell shape determining protein MreB Mrl
WS08_RS01670	COG0765	amino acid transport
WS08_RS01685	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WS08_RS01710	COG0833	amino acid
WS08_RS01720	COG2264	protein methyltransferase activity
WS08_RS01725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WS08_RS01730	COG2001	Belongs to the MraZ family
WS08_RS01735	COG0275	rRNA processing
WS08_RS01745	COG0768	penicillin binding
WS08_RS01755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WS08_RS01760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WS08_RS01770	COG0849	cell division
WS08_RS01775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WS08_RS01780	COG1799	cell septum assembly
WS08_RS01785	COG0762	integral membrane protein
WS08_RS01790	COG2302	S4 RNA-binding domain
WS08_RS01795	COG3599	regulation of cell shape
WS08_RS01800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WS08_RS01815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WS08_RS01820	COG0217	transcriptional regulatory protein
WS08_RS01825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WS08_RS01830	COG1459	type II secretion system
WS08_RS01835	COG4537	Required for transformation and DNA binding
WS08_RS01860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WS08_RS01865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WS08_RS01870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WS08_RS01870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WS08_RS01880	COG2815	serine threonine protein kinase
WS08_RS01880	COG0515	serine threonine protein kinase
WS08_RS01885	COG1162	GTPase activity
WS08_RS01890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WS08_RS01900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WS08_RS01910	COG1461	Dihydroxyacetone kinase
WS08_RS01915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WS08_RS01920	COG0416	fatty acid biosynthetic process
WS08_RS01925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WS08_RS01930	COG0571	ribonuclease III activity
WS08_RS01935	COG1196	nuclear chromosome segregation
WS08_RS01940	COG0552	protein localization to endoplasmic reticulum
WS08_RS01945	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
WS08_RS01950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WS08_RS01955	COG0228	four-way junction DNA binding
WS08_RS01960	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WS08_RS01965	COG0336	Belongs to the RNA methyltransferase TrmD family
WS08_RS01970	COG0335	large ribosomal subunit rRNA binding
WS08_RS01975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WS08_RS01980	COG1942	4-Oxalocrotonate Tautomerase
WS08_RS01985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WS08_RS01990	COG0494	nUDIX hydrolase
WS08_RS01995	COG1428	Deoxynucleoside kinase
WS08_RS02005	COG0561	phosphatase activity
WS08_RS02030	COG4862	establishment of competence for transformation
WS08_RS02050	COG0006	proline dipeptidase activity
WS08_RS02055	COG1609	Transcriptional regulator
WS08_RS02100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WS08_RS02105	COG3425	synthase
WS08_RS02115	COG0860	N-Acetylmuramoyl-L-alanine amidase
WS08_RS02120	COG0124	histidyl-tRNA synthetase
WS08_RS02125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WS08_RS02130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WS08_RS02135	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WS08_RS02140	COG1610	YqeY-like protein
WS08_RS02145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WS08_RS02150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WS08_RS02155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WS08_RS02160	COG1381	Involved in DNA repair and RecF pathway recombination
WS08_RS02165	COG0752	glycyl-tRNA synthetase alpha subunit
WS08_RS02170	COG0751	glycine-tRNA ligase activity
WS08_RS02185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WS08_RS02190	COG1620	l-lactate permease
WS08_RS02200	COG2706	6-phosphogluconolactonase activity
WS08_RS02210	COG1674	ftsk spoiiie
WS08_RS02215	COG4152	abc transporter atp-binding protein
WS08_RS02220	COG1668	transmembrane transport
WS08_RS02225	COG0584	glycerophosphoryl diester phosphodiesterase
WS08_RS02230	COG0322	excinuclease ABC activity
WS08_RS02245	COG1739	Uncharacterized protein family UPF0029
WS08_RS02255	COG0517	IMP dehydrogenase activity
WS08_RS02255	COG0516	GMP reductase activity
WS08_RS02260	COG0632	four-way junction helicase activity
WS08_RS02265	COG2255	four-way junction helicase activity
WS08_RS02305	COG1862	Preprotein translocase
WS08_RS02310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WS08_RS02315	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WS08_RS02320	COG0513	Belongs to the DEAD box helicase family
WS08_RS02325	COG0110	maltose O-acetyltransferase activity
WS08_RS02330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WS08_RS02345	COG3906	Belongs to the UPF0473 family
WS08_RS02350	COG3906	Belongs to the UPF0473 family
WS08_RS02355	COG1555	photosystem II stabilization
WS08_RS02360	COG2333	competence protein COMEC
WS08_RS02360	COG0658	competence protein
WS08_RS02365	COG1466	dna polymerase III delta subunit
WS08_RS02370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WS08_RS02375	COG0268	Binds directly to 16S ribosomal RNA
WS08_RS02410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WS08_RS02425	COG1193	negative regulation of DNA recombination
WS08_RS02435	COG3118	belongs to the thioredoxin family
WS08_RS02440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WS08_RS02445	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WS08_RS02455	COG2357	RelA SpoT domain protein
WS08_RS02460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WS08_RS02465	COG0564	pseudouridine synthase activity
WS08_RS02470	COG2239	Acts as a magnesium transporter
WS08_RS02475	COG0779	Required for maturation of 30S ribosomal subunits
WS08_RS02480	COG0195	Participates in both transcription termination and antitermination
WS08_RS02485	COG2740	Nucleic-acid-binding protein implicated in transcription termination
WS08_RS02495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WS08_RS02500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WS08_RS02505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WS08_RS02510	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WS08_RS02520	COG0196	riboflavin kinase activity
WS08_RS02530	COG3142	Participates in the control of copper homeostasis
WS08_RS02535	COG1307	EDD domain protein, DegV family
WS08_RS02540	COG1307	EDD domain protein, DegV family
WS08_RS02545	COG0277	FAD linked oxidase domain protein
WS08_RS02550	COG4479	Belongs to the UPF0346 family
WS08_RS02555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WS08_RS02560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WS08_RS02580	COG0758	DNA mediated transformation
WS08_RS02585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WS08_RS02590	COG4974	Belongs to the 'phage' integrase family
WS08_RS02605	COG2814	Major facilitator Superfamily
WS08_RS02615	COG0187	DNA topoisomerase II activity
WS08_RS02620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WS08_RS02640	COG1227	inorganic diphosphatase activity
WS08_RS02650	COG3448	diguanylate cyclase activity
WS08_RS02650	COG4175	Glycine betaine
WS08_RS02680	COG1011	Hydrolase
WS08_RS02700	COG5503	Protein of unknown function (DUF1447)
WS08_RS02710	COG0242	peptide deformylase activity
WS08_RS02715	COG4476	Belongs to the UPF0223 family
WS08_RS02720	COG0483	inositol monophosphate 1-phosphatase activity
WS08_RS02725	COG1217	gtp-binding protein TYPA
WS08_RS02730	COG0772	Belongs to the SEDS family
WS08_RS02735	COG4471	UPF0298 protein
WS08_RS02740	COG0742	ribosomal rna small subunit methyltransferase
WS08_RS02745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WS08_RS02750	COG3480	Lon protease (S16) C-terminal proteolytic domain
WS08_RS02755	COG0477	Major facilitator Superfamily
WS08_RS02760	COG0358	DNA primase activity
WS08_RS02765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WS08_RS02775	COG0745	RESPONSE REGULATOR receiver
WS08_RS02780	COG5002	protein histidine kinase activity
WS08_RS02785	COG0572	uridine kinase
WS08_RS02790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS08_RS02800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WS08_RS02805	COG0670	Belongs to the BI1 family
WS08_RS02825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WS08_RS02830	COG0237	dephospho-CoA kinase activity
WS08_RS02840	COG1484	DNA-dependent DNA replication
WS08_RS02855	COG0745	RESPONSE REGULATOR receiver
WS08_RS02860	COG5002	protein histidine kinase activity
WS08_RS02885	COG1686	Belongs to the peptidase S11 family
WS08_RS02890	COG0626	cystathionine gamma-synthase activity
WS08_RS02915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WS08_RS02925	COG0488	(ABC) transporter
WS08_RS02975	COG1304	FMN binding
WS08_RS02990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WS08_RS03005	COG4690	dipeptidase activity
WS08_RS03090	COG1216	Glycosyl transferase, family 2
WS08_RS03095	COG1272	protein, Hemolysin III
WS08_RS03100	COG1268	BioY protein
WS08_RS03115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WS08_RS03120	COG0439	Biotin carboxylase
WS08_RS03125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WS08_RS03135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WS08_RS03145	COG0604	alcohol dehydrogenase
WS08_RS03145	COG3321	synthase
WS08_RS03160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WS08_RS03170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WS08_RS03175	COG2755	lipolytic protein G-D-S-L family
WS08_RS03175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
WS08_RS03190	COG0446	pyridine nucleotide-disulphide oxidoreductase
WS08_RS03210	COG0352	thiamine-phosphate diphosphorylase activity
WS08_RS03215	COG0351	phosphomethylpyrimidine kinase
WS08_RS03220	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
WS08_RS03225	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
WS08_RS03235	COG0584	glycerophosphoryl diester phosphodiesterase
WS08_RS03250	COG0561	phosphatase activity
WS08_RS03270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WS08_RS03280	COG1131	(ABC) transporter
WS08_RS03285	COG0537	adenosine 5'-monophosphoramidase activity
WS08_RS03295	COG0556	nucleotide-excision repair
WS08_RS03310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WS08_RS03340	COG0116	Belongs to the methyltransferase superfamily
WS08_RS03345	COG3599	regulation of cell shape
WS08_RS03350	COG4474	Belongs to the UPF0398 family
WS08_RS03355	COG3331	DNA recombination
WS08_RS03370	COG3935	DnaD domain protein
WS08_RS03380	COG0017	Asparaginyl-tRNA synthetase
WS08_RS03390	COG1199	ATP-dependent helicase activity
WS08_RS03390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WS08_RS03395	COG2261	transglycosylase associated protein
WS08_RS03465	COG1304	FMN binding
WS08_RS03470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WS08_RS03475	COG0706	membrane insertase activity
WS08_RS03485	COG0105	UTP biosynthetic process
WS08_RS03490	COG0531	amino acid
WS08_RS03500	COG2855	membrane
WS08_RS03510	COG1215	transferase activity, transferring glycosyl groups
WS08_RS03520	COG0183	Belongs to the thiolase family
WS08_RS03530	COG0735	belongs to the Fur family
WS08_RS03540	COG0390	transport system, permease component
WS08_RS03545	COG4619	ABC transporter
WS08_RS03550	COG2267	carboxylic ester hydrolase activity
WS08_RS03555	COG2390	Transcriptional regulator
WS08_RS03565	COG1136	(ABC) transporter
WS08_RS03595	COG0095	Lipoate-protein ligase
WS08_RS03600	COG0366	Alpha amylase catalytic
WS08_RS03620	COG0741	lytic transglycosylase activity
WS08_RS03630	COG1694	Mazg nucleotide pyrophosphohydrolase
WS08_RS03635	COG1611	Belongs to the LOG family
WS08_RS03650	COG1609	Transcriptional regulator
WS08_RS03660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WS08_RS03665	COG0151	Belongs to the GarS family
WS08_RS03670	COG0138	bifunctional purine biosynthesis protein purh
WS08_RS03675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WS08_RS03680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WS08_RS03690	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WS08_RS03695	COG0047	phosphoribosylformylglycinamidine synthase activity
WS08_RS03700	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WS08_RS03705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WS08_RS03710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WS08_RS03715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WS08_RS03720	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
WS08_RS03725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WS08_RS03730	COG1696	Membrane protein involved in D-alanine export
WS08_RS03750	COG0481	GTPase activity
WS08_RS03770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WS08_RS03775	COG3475	LICD family
WS08_RS03800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WS08_RS03805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WS08_RS03820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WS08_RS03825	COG2195	Cleaves the N-terminal amino acid of tripeptides
WS08_RS03830	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WS08_RS03835	COG2384	SAM-dependent methyltransferase
WS08_RS03840	COG0457	Tetratricopeptide repeat
WS08_RS03865	COG2807	transmembrane transport
WS08_RS03870	COG4720	Psort location CytoplasmicMembrane, score
WS08_RS03875	COG0351	phosphomethylpyrimidine kinase
WS08_RS03885	COG1160	GTP binding
WS08_RS03890	COG0539	negative regulation of cytoplasmic translation
WS08_RS03895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WS08_RS03905	COG0514	ATP-dependent DNA helicase (RecQ)
WS08_RS03915	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
WS08_RS03920	COG1187	pseudouridine synthase activity
WS08_RS03925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WS08_RS03930	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WS08_RS03935	COG0456	acetyltransferase
WS08_RS03945	COG2996	Protein conserved in bacteria
WS08_RS03955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WS08_RS03960	COG0149	triose-phosphate isomerase activity
WS08_RS03965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WS08_RS03975	COG3835	regulator
WS08_RS03980	COG0475	glutathione-regulated potassium exporter activity
WS08_RS03990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WS08_RS03995	COG0587	DNA-directed DNA polymerase activity
WS08_RS04010	COG0488	(ABC) transporter
WS08_RS04015	COG0617	tRNA 3'-terminal CCA addition
WS08_RS04030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WS08_RS04040	COG1316	TRANSCRIPTIONal
WS08_RS04055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WS08_RS04065	COG0052	Belongs to the universal ribosomal protein uS2 family
WS08_RS04070	COG2827	Endonuclease containing a URI domain
WS08_RS04075	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WS08_RS04080	COG0204	Acyl-transferase
WS08_RS04085	COG3763	UPF0154 protein
WS08_RS04090	COG4224	UPF0291 protein
WS08_RS04095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WS08_RS04100	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
WS08_RS04100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WS08_RS04105	COG1234	tRNA 3'-trailer cleavage
WS08_RS04120	COG0484	heat shock protein binding
WS08_RS04125	COG0443	Heat shock 70 kDa protein
WS08_RS04130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WS08_RS04135	COG1420	regulation of RNA biosynthetic process
WS08_RS04150	COG0463	Glycosyl transferase, family 2
WS08_RS04165	COG0024	Methionine aminopeptidase
WS08_RS04175	COG1682	transport, permease protein
WS08_RS04180	COG1388	LysM domain
WS08_RS04180	COG1134	teichoic acid transport
WS08_RS04190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WS08_RS04195	COG2309	aminopeptidase activity
WS08_RS04200	COG1278	Cold shock
WS08_RS04210	COG2814	Major facilitator Superfamily
WS08_RS04215	COG1388	LysM domain
WS08_RS04220	COG1072	(Pantothenic acid kinase))
WS08_RS04225	COG3973	AAA domain
WS08_RS04230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WS08_RS04235	COG1058	Belongs to the CinA family
WS08_RS04235	COG1546	Belongs to the CinA family
WS08_RS04240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WS08_RS04245	COG1426	Protein conserved in bacteria
WS08_RS04255	COG0612	Peptidase, M16
WS08_RS04260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WS08_RS04280	COG1070	Carbohydrate kinase
WS08_RS04285	COG3481	metal-dependent phosphohydrolase, HD sub domain
WS08_RS04290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WS08_RS04295	COG0420	3'-5' exonuclease activity
WS08_RS04305	COG3679	Belongs to the UPF0342 family
WS08_RS04310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WS08_RS04315	COG1438	arginine binding
WS08_RS04320	COG0018	arginyl-trna synthetase
WS08_RS04335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WS08_RS04345	COG1597	lipid kinase activity
WS08_RS04350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WS08_RS04360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WS08_RS04365	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WS08_RS04365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WS08_RS04385	COG0667	Aldo Keto reductase
WS08_RS04390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WS08_RS04395	COG0167	dihydroorotate dehydrogenase activity
WS08_RS04400	COG3859	Proton-coupled thiamine transporter YuaJ
WS08_RS04410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WS08_RS04415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WS08_RS04420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WS08_RS04425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WS08_RS04430	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
WS08_RS04435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WS08_RS04455	COG4684	Psort location CytoplasmicMembrane, score
WS08_RS04460	COG0436	Aminotransferase
WS08_RS04470	COG0436	Aminotransferase
WS08_RS04480	COG1609	Transcriptional regulator
WS08_RS04505	COG1321	iron dependent repressor
WS08_RS04505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WS08_RS04515	COG3764	Sortase (surface protein transpeptidase)
WS08_RS04520	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
WS08_RS04525	COG0513	Belongs to the DEAD box helicase family
WS08_RS04530	COG0673	inositol 2-dehydrogenase activity
WS08_RS04535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WS08_RS04540	COG0501	Belongs to the peptidase M48B family
WS08_RS04545	COG1704	LemA family
WS08_RS04560	COG2153	protein acetylation
WS08_RS04580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WS08_RS04585	COG0562	UDP-galactopyranose mutase
WS08_RS04590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WS08_RS04595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WS08_RS04605	COG0505	Belongs to the CarA family
WS08_RS04615	COG0564	pseudouridine synthase activity
WS08_RS04625	COG1757	Na H antiporter
WS08_RS04630	COG1113	amino acid transport
WS08_RS04645	COG0126	phosphoglycerate kinase activity
WS08_RS04675	COG0737	Belongs to the 5'-nucleotidase family
WS08_RS04720	COG3716	PTS system mannose fructose sorbose family IID component
WS08_RS04725	COG3715	PTS system
WS08_RS04795	COG1185	polyribonucleotide nucleotidyltransferase activity
WS08_RS04805	COG0586	Pfam SNARE associated Golgi protein
WS08_RS04810	COG1758	RNA polymerase activity
WS08_RS04815	COG0194	GDP metabolic process
WS08_RS04820	COG0497	DNA recombination
WS08_RS04825	COG1438	arginine binding
WS08_RS04830	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
WS08_RS04840	COG1722	exodeoxyribonuclease VII activity
WS08_RS04845	COG1570	exodeoxyribonuclease VII activity
WS08_RS04850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WS08_RS04855	COG4720	Psort location CytoplasmicMembrane, score
WS08_RS04870	COG0363	glucosamine-6-phosphate deaminase activity
WS08_RS04875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WS08_RS04890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WS08_RS04900	COG1323	Belongs to the UPF0348 family
WS08_RS04910	COG0799	negative regulation of ribosome biogenesis
WS08_RS04915	COG1713	HD superfamily hydrolase involved in NAD metabolism
WS08_RS04920	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WS08_RS04930	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WS08_RS04935	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
WS08_RS04940	COG1181	Belongs to the D-alanine--D-alanine ligase family
WS08_RS04950	COG0531	amino acid
WS08_RS04955	COG0459	protein refolding
WS08_RS04960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WS08_RS04965	COG0488	(ABC) transporter
WS08_RS04970	COG0285	dihydrofolate synthase activity
WS08_RS04975	COG0525	valine-tRNA ligase activity
WS08_RS04980	COG1279	arginine transmembrane transporter activity
WS08_RS04985	COG0589	response to stress
WS08_RS05000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WS08_RS05025	COG3557	Belongs to the UPF0374 family
WS08_RS05030	COG2137	regulation of response to DNA damage stimulus
WS08_RS05040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WS08_RS05050	COG0581	inorganic phosphate transmembrane transporter activity
WS08_RS05055	COG0573	inorganic phosphate transmembrane transporter activity
WS08_RS05080	COG0393	Putative heavy-metal-binding
WS08_RS05085	COG0647	UMP catabolic process
WS08_RS05090	COG4470	Protein conserved in bacteria
WS08_RS05095	COG0737	Belongs to the 5'-nucleotidase family
WS08_RS05105	COG0006	proline dipeptidase activity
WS08_RS05125	COG0596	Alpha beta hydrolase
WS08_RS05130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WS08_RS05135	COG1169	isochorismate synthase
WS08_RS05150	COG0531	amino acid
WS08_RS05160	COG2814	Major facilitator Superfamily
WS08_RS05170	COG1063	alcohol dehydrogenase
WS08_RS05175	COG0813	purine-nucleoside phosphorylase activity
WS08_RS05180	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WS08_RS05190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WS08_RS05200	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WS08_RS05205	COG1447	Phosphotransferase system cellobiose-specific component IIA
WS08_RS05210	COG1120	ATPase activity
WS08_RS05240	COG1686	Belongs to the peptidase S11 family
WS08_RS05245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WS08_RS05250	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WS08_RS05255	COG2271	Major facilitator Superfamily
WS08_RS05285	COG0174	glutamine synthetase
WS08_RS05290	COG0789	Transcriptional regulator
WS08_RS05295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WS08_RS05310	COG1940	carbohydrate kinase activity
WS08_RS05325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WS08_RS05330	COG0768	penicillin binding
WS08_RS05340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WS08_RS05345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WS08_RS05350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS08_RS05350	COG0072	phenylalanine-tRNA ligase activity
WS08_RS05355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WS08_RS05360	COG1733	regulation of RNA biosynthetic process
WS08_RS05370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WS08_RS05385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WS08_RS05390	COG0653	protein targeting
WS08_RS05405	COG0756	dUTP diphosphatase activity
WS08_RS05415	COG0791	NLP P60 protein
WS08_RS05425	COG0542	response to heat
WS08_RS05430	COG0604	alcohol dehydrogenase
WS08_RS05435	COG0028	Belongs to the TPP enzyme family
WS08_RS05440	COG3527	Alpha-acetolactate decarboxylase
WS08_RS05470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WS08_RS05485	COG0740	serine-type endopeptidase activity
WS08_RS05495	COG1481	regulation of sporulation
WS08_RS05500	COG0391	Required for morphogenesis under gluconeogenic growth conditions
WS08_RS05505	COG1660	Displays ATPase and GTPase activities
WS08_RS05515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WS08_RS05550	COG0101	tRNA pseudouridine synthase activity
WS08_RS05560	COG1122	ATPase activity
WS08_RS05565	COG1122	ATPase activity
WS08_RS05570	COG3594	Acyltransferase
WS08_RS05585	COG0803	Belongs to the bacterial solute-binding protein 9 family
WS08_RS05590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WS08_RS05595	COG1121	(ABC) transporter
WS08_RS05610	COG0222	ribosome binding
WS08_RS05615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WS08_RS05620	COG0081	regulation of translation
WS08_RS05625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WS08_RS05630	COG0250	Participates in transcription elongation, termination and antitermination
WS08_RS05635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WS08_RS05645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WS08_RS05650	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
WS08_RS05655	COG0215	cysteine-tRNA ligase activity
WS08_RS05670	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
WS08_RS05680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WS08_RS05690	COG0203	ribosomal protein L17
WS08_RS05695	COG0202	RNA polymerase activity
WS08_RS05700	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WS08_RS05705	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WS08_RS05710	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WS08_RS05715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WS08_RS05730	COG0200	Binds to the 23S rRNA
WS08_RS05735	COG1841	ribosomal large subunit assembly
WS08_RS05740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WS08_RS05745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WS08_RS05750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WS08_RS05755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WS08_RS05760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WS08_RS05765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WS08_RS05770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WS08_RS05780	COG0255	Belongs to the universal ribosomal protein uL29 family
WS08_RS05785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WS08_RS05790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WS08_RS05795	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WS08_RS05800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WS08_RS05805	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WS08_RS05810	COG0089	rRNA binding
WS08_RS05820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WS08_RS05825	COG0051	transcription antitermination factor activity, RNA binding
WS08_RS05850	COG1214	PFAM Peptidase M22, glycoprotease
WS08_RS05855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WS08_RS05875	COG3870	Protein conserved in bacteria
WS08_RS05880	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WS08_RS05890	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WS08_RS05895	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WS08_RS05900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WS08_RS05910	COG2813	Specifically methylates the guanine in position
WS08_RS05945	COG1979	alcohol dehydrogenase
WS08_RS05950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WS08_RS05955	COG0085	RNA polymerase activity
WS08_RS05965	COG4463	regulation of RNA biosynthetic process
WS08_RS05985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WS08_RS05990	COG1428	Deoxynucleoside kinase
WS08_RS06000	COG1686	Belongs to the peptidase S11 family
WS08_RS06005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WS08_RS06010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WS08_RS06015	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WS08_RS06020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WS08_RS06025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WS08_RS06030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WS08_RS06035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WS08_RS06040	COG0356	it plays a direct role in the translocation of protons across the membrane
WS08_RS06045	COG2233	PERMEase
WS08_RS06055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WS08_RS06060	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WS08_RS06065	COG0009	L-threonylcarbamoyladenylate synthase
WS08_RS06070	COG2890	protein-(glutamine-N5) methyltransferase activity
WS08_RS06075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WS08_RS06080	COG1435	thymidine kinase activity
WS08_RS06085	COG3442	glutamine amidotransferase
WS08_RS06090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WS08_RS06095	COG1482	cell wall glycoprotein biosynthetic process
WS08_RS06115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WS08_RS06140	COG1132	(ABC) transporter
WS08_RS06145	COG1132	(ABC) transporter
WS08_RS06150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WS08_RS06155	COG0588	phosphoglycerate mutase activity
WS08_RS06170	COG1573	uracil-dna glycosylase
WS08_RS06175	COG2610	gluconate transmembrane transporter activity
WS08_RS06180	COG0708	Exodeoxyribonuclease III
WS08_RS06185	COG1012	belongs to the aldehyde dehydrogenase family
WS08_RS06185	COG1454	alcohol dehydrogenase
WS08_RS06190	COG2235	arginine
WS08_RS06195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WS08_RS06200	COG0531	amino acid
WS08_RS06210	COG3590	peptidase
WS08_RS06225	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
WS08_RS06230	COG2188	Transcriptional regulator
WS08_RS06235	COG1418	mRNA catabolic process
WS08_RS06265	COG0488	(ABC) transporter
WS08_RS06275	COG1121	(ABC) transporter
WS08_RS06285	COG1846	Transcriptional regulator
WS08_RS06290	COG3091	SprT-like family
WS08_RS06330	COG3104	oligopeptide transport
WS08_RS06340	COG5002	protein histidine kinase activity
WS08_RS06345	COG0745	RESPONSE REGULATOR receiver
WS08_RS06355	COG0012	GTP binding
WS08_RS06360	COG4481	Protein conserved in bacteria
WS08_RS06365	COG1475	DNA binding
WS08_RS06370	COG1192	Involved in chromosome partitioning
WS08_RS06375	COG0357	Ribosomal RNA small subunit methyltransferase G
WS08_RS06380	COG1194	a g-specific adenine glycosylase
WS08_RS06385	COG5002	protein histidine kinase activity
WS08_RS06390	COG0745	RESPONSE REGULATOR receiver
WS08_RS06395	COG0318	PFAM AMP-dependent synthetase and ligase
WS08_RS06400	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WS08_RS06410	COG1335	isochorismatase
WS08_RS06420	COG4443	Transcriptional Coactivator p15 (PC4)
WS08_RS06425	COG0252	asparaginase activity
WS08_RS06430	COG0531	amino acid
WS08_RS06440	COG2130	NADP-dependent
WS08_RS06450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WS08_RS06485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WS08_RS06500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WS08_RS06505	COG1554	hydrolase, family 65, central catalytic
WS08_RS06510	COG1263	PTS System
WS08_RS06510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WS08_RS06510	COG2190	(PTS) system
WS08_RS06515	COG1263	PTS System
WS08_RS06515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WS08_RS06515	COG2190	(PTS) system
WS08_RS06520	COG2188	Transcriptional regulator
WS08_RS06530	COG1511	domain protein
WS08_RS06535	COG1959	2 iron, 2 sulfur cluster binding
WS08_RS06545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WS08_RS06550	COG3620	sequence-specific DNA binding
WS08_RS06570	COG0657	acetylesterase activity
WS08_RS06575	COG1113	amino acid transport
WS08_RS06580	COG0628	permease
WS08_RS06590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WS08_RS06595	COG0765	amino acid transport
WS08_RS06600	COG1126	abc transporter atp-binding protein
WS08_RS06610	COG0640	Transcriptional regulator
WS08_RS06615	COG2217	Heavy metal translocating P-type atpase
WS08_RS06620	COG1309	transcriptional regulator
WS08_RS06625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WS08_RS06630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WS08_RS06645	COG0028	Belongs to the TPP enzyme family
WS08_RS06655	COG4221	oxidoreductase activity
WS08_RS06660	COG0346	lactoylglutathione lyase activity
WS08_RS06665	COG0656	L-ascorbic acid biosynthetic process
WS08_RS06670	COG1733	regulation of RNA biosynthetic process
WS08_RS06675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WS08_RS06695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WS08_RS06700	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WS08_RS06705	COG1113	amino acid transport
WS08_RS06710	COG0569	domain protein
WS08_RS06720	COG0706	membrane insertase activity
WS08_RS06725	COG0594	ribonuclease P activity
WS08_RS06750	COG1266	CAAX protease self-immunity