locus-tag	class	description
WS105_RS00005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WS105_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WS105_RS00020	COG2501	S4 domain
WS105_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WS105_RS00030	COG0187	DNA topoisomerase II activity
WS105_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WS105_RS00040	COG1368	sulfuric ester hydrolase activity
WS105_RS00095	COG1737	Transcriptional regulator
WS105_RS00100	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
WS105_RS00125	COG2233	PERMEase
WS105_RS00130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WS105_RS00180	COG2252	PERMEase
WS105_RS00190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WS105_RS00195	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WS105_RS00200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WS105_RS00205	COG2818	Glycosylase
WS105_RS00215	COG0495	leucyl-tRNA aminoacylation
WS105_RS00225	COG2244	polysaccharide biosynthetic process
WS105_RS00235	COG0531	amino acid
WS105_RS00245	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
WS105_RS00250	COG1074	ATP-dependent DNA helicase activity
WS105_RS00255	COG1064	alcohol dehydrogenase
WS105_RS00270	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WS105_RS00275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WS105_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WS105_RS00285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WS105_RS00290	COG4493	Belongs to the UPF0637 family
WS105_RS00295	COG0360	Binds together with S18 to 16S ribosomal RNA
WS105_RS00300	COG0629	single-stranded DNA binding
WS105_RS00305	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WS105_RS00320	COG0745	RESPONSE REGULATOR receiver
WS105_RS00325	COG5002	protein histidine kinase activity
WS105_RS00340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
WS105_RS00345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WS105_RS00355	COG1078	dGTPase activity
WS105_RS00360	COG0561	phosphatase activity
WS105_RS00365	COG3343	RNA polymerase activity
WS105_RS00370	COG0504	CTP synthase activity
WS105_RS00375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WS105_RS00395	COG2337	Toxic component of a toxin-antitoxin (TA) module
WS105_RS00400	COG3973	AAA domain
WS105_RS00410	COG0248	Ppx GppA phosphatase
WS105_RS00435	COG0194	GDP metabolic process
WS105_RS00455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WS105_RS00460	COG0765	amino acid transport
WS105_RS00465	COG0765	amino acid transport
WS105_RS00470	COG4166	transmembrane transport
WS105_RS00475	COG4166	transmembrane transport
WS105_RS00480	COG0601	transmembrane transport
WS105_RS00485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WS105_RS00490	COG0444	Belongs to the ABC transporter superfamily
WS105_RS00495	COG4608	Belongs to the ABC transporter superfamily
WS105_RS00505	COG0359	binds to the 23S rRNA
WS105_RS00515	COG2814	Major facilitator Superfamily
WS105_RS00530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WS105_RS00540	COG0492	ferredoxin-NADP+ reductase activity
WS105_RS00545	COG0588	phosphoglycerate mutase activity
WS105_RS00550	COG1134	teichoic acid transport
WS105_RS00550	COG1388	LysM domain
WS105_RS00565	COG0586	Pfam SNARE associated Golgi protein
WS105_RS00580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WS105_RS00585	COG1077	Cell shape determining protein MreB Mrl
WS105_RS00595	COG0772	Belongs to the SEDS family
WS105_RS00600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WS105_RS00610	COG0561	phosphatase activity
WS105_RS00615	COG1136	(ABC) transporter
WS105_RS00615	COG0577	efflux transmembrane transporter activity
WS105_RS00625	COG2188	Transcriptional regulator
WS105_RS00630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WS105_RS00645	COG2252	PERMEase
WS105_RS00675	COG0561	phosphatase activity
WS105_RS00680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WS105_RS00685	COG4589	Belongs to the CDS family
WS105_RS00690	COG0750	zinc metalloprotease
WS105_RS00695	COG0442	prolyl-tRNA aminoacylation
WS105_RS00700	COG2176	DNA-directed DNA polymerase activity
WS105_RS00740	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
WS105_RS00765	COG2183	response to ionizing radiation
WS105_RS00775	COG2217	Heavy metal translocating P-type atpase
WS105_RS00905	COG3706	GGDEF domain
WS105_RS00910	COG0716	FMN binding
WS105_RS00915	COG2199	diguanylate cyclase activity
WS105_RS00940	COG1869	D-ribose catabolic process
WS105_RS00955	COG0668	transmembrane transport
WS105_RS00960	COG4975	Glucose uptake
WS105_RS00965	COG0166	Belongs to the GPI family
WS105_RS00970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WS105_RS00975	COG1302	Protein conserved in bacteria
WS105_RS00980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WS105_RS00990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WS105_RS00995	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WS105_RS01005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WS105_RS01010	COG0049	tRNA binding
WS105_RS01015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WS105_RS01020	COG0673	inositol 2-dehydrogenase activity
WS105_RS01025	COG3842	ATPase activity
WS105_RS01035	COG1177	transmembrane transport
WS105_RS01040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WS105_RS01045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WS105_RS01050	COG1950	PFAM Membrane protein of
WS105_RS01055	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
WS105_RS01060	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WS105_RS01070	COG0492	ferredoxin-NADP+ reductase activity
WS105_RS01085	COG0149	triose-phosphate isomerase activity
WS105_RS01100	COG0557	exoribonuclease II activity
WS105_RS01105	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WS105_RS01115	COG1126	abc transporter atp-binding protein
WS105_RS01120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WS105_RS01125	COG0280	phosphate acetyltransferase
WS105_RS01130	COG0802	atpase or kinase
WS105_RS01145	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WS105_RS01170	COG0540	Belongs to the ATCase OTCase family
WS105_RS01180	COG0505	Belongs to the CarA family
WS105_RS01185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WS105_RS01190	COG0284	orotidine-5'-phosphate decarboxylase activity
WS105_RS01195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WS105_RS01200	COG0438	transferase activity, transferring glycosyl groups
WS105_RS01205	COG0438	transferase activity, transferring glycosyl groups
WS105_RS01215	COG1368	sulfuric ester hydrolase activity
WS105_RS01235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS105_RS01235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS105_RS01240	COG0025	NhaP-type Na H and K H
WS105_RS01245	COG0084	hydrolase, TatD family'
WS105_RS01250	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
WS105_RS01255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WS105_RS01260	COG1253	flavin adenine dinucleotide binding
WS105_RS01265	COG2131	deaminase
WS105_RS01275	COG1316	TRANSCRIPTIONal
WS105_RS01280	COG1983	PspC domain protein
WS105_RS01285	COG1968	undecaprenyl-diphosphatase activity
WS105_RS01305	COG0193	aminoacyl-tRNA hydrolase activity
WS105_RS01310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WS105_RS01315	COG2244	polysaccharide biosynthetic process
WS105_RS01320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WS105_RS01345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WS105_RS01350	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WS105_RS01485	COG1271	oxidase subunit
WS105_RS01490	COG1294	oxidase, subunit
WS105_RS01495	COG4988	ABC transporter
WS105_RS01500	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WS105_RS01505	COG1705	Flagellar rod assembly protein muramidase FlgJ
WS105_RS01535	COG0494	nUDIX hydrolase
WS105_RS01545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WS105_RS01560	COG1388	LysM domain
WS105_RS01570	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WS105_RS01575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WS105_RS01580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WS105_RS01590	COG4120	Belongs to the binding-protein-dependent transport system permease family
WS105_RS01595	COG1116	anion transmembrane transporter activity
WS105_RS01615	COG2003	Belongs to the UPF0758 family
WS105_RS01640	COG0765	amino acid transport
WS105_RS01655	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WS105_RS01680	COG0833	amino acid
WS105_RS01690	COG2264	protein methyltransferase activity
WS105_RS01695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WS105_RS01700	COG2001	Belongs to the MraZ family
WS105_RS01705	COG0275	rRNA processing
WS105_RS01715	COG0768	penicillin binding
WS105_RS01725	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WS105_RS01730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WS105_RS01740	COG0849	cell division
WS105_RS01745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WS105_RS01750	COG1799	cell septum assembly
WS105_RS01755	COG0762	integral membrane protein
WS105_RS01760	COG2302	S4 RNA-binding domain
WS105_RS01765	COG3599	regulation of cell shape
WS105_RS01770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WS105_RS01785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WS105_RS01790	COG0217	transcriptional regulatory protein
WS105_RS01795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WS105_RS01800	COG1459	type II secretion system
WS105_RS01805	COG4537	Required for transformation and DNA binding
WS105_RS01830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WS105_RS01835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WS105_RS01840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WS105_RS01840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WS105_RS01850	COG0515	serine threonine protein kinase
WS105_RS01850	COG2815	serine threonine protein kinase
WS105_RS01855	COG1162	GTPase activity
WS105_RS01860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WS105_RS01870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WS105_RS01880	COG1461	Dihydroxyacetone kinase
WS105_RS01885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WS105_RS01890	COG0416	fatty acid biosynthetic process
WS105_RS01895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WS105_RS01900	COG0571	ribonuclease III activity
WS105_RS01910	COG0552	protein localization to endoplasmic reticulum
WS105_RS01915	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
WS105_RS01920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WS105_RS01925	COG0228	four-way junction DNA binding
WS105_RS01930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WS105_RS01935	COG0336	Belongs to the RNA methyltransferase TrmD family
WS105_RS01940	COG0335	large ribosomal subunit rRNA binding
WS105_RS01945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WS105_RS01950	COG1942	4-Oxalocrotonate Tautomerase
WS105_RS01955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WS105_RS01960	COG0494	nUDIX hydrolase
WS105_RS01965	COG1428	Deoxynucleoside kinase
WS105_RS01975	COG0561	phosphatase activity
WS105_RS02000	COG4862	establishment of competence for transformation
WS105_RS02020	COG0006	proline dipeptidase activity
WS105_RS02025	COG1609	Transcriptional regulator
WS105_RS02070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WS105_RS02075	COG3425	synthase
WS105_RS02085	COG0860	N-Acetylmuramoyl-L-alanine amidase
WS105_RS02090	COG0124	histidyl-tRNA synthetase
WS105_RS02095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WS105_RS02100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WS105_RS02105	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WS105_RS02110	COG1610	YqeY-like protein
WS105_RS02115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WS105_RS02120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WS105_RS02125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WS105_RS02130	COG1381	Involved in DNA repair and RecF pathway recombination
WS105_RS02135	COG0752	glycyl-tRNA synthetase alpha subunit
WS105_RS02140	COG0751	glycine-tRNA ligase activity
WS105_RS02155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WS105_RS02160	COG1620	l-lactate permease
WS105_RS02170	COG2706	6-phosphogluconolactonase activity
WS105_RS02180	COG1674	ftsk spoiiie
WS105_RS02185	COG4152	abc transporter atp-binding protein
WS105_RS02195	COG0584	glycerophosphoryl diester phosphodiesterase
WS105_RS02200	COG0322	excinuclease ABC activity
WS105_RS02215	COG1739	Uncharacterized protein family UPF0029
WS105_RS02225	COG0517	IMP dehydrogenase activity
WS105_RS02225	COG0516	GMP reductase activity
WS105_RS02230	COG0632	four-way junction helicase activity
WS105_RS02235	COG2255	four-way junction helicase activity
WS105_RS02275	COG1862	Preprotein translocase
WS105_RS02280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WS105_RS02285	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WS105_RS02290	COG0513	Belongs to the DEAD box helicase family
WS105_RS02295	COG0110	maltose O-acetyltransferase activity
WS105_RS02300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WS105_RS02315	COG3906	Belongs to the UPF0473 family
WS105_RS02320	COG3906	Belongs to the UPF0473 family
WS105_RS02325	COG1555	photosystem II stabilization
WS105_RS02330	COG2333	competence protein COMEC
WS105_RS02330	COG0658	competence protein
WS105_RS02335	COG1466	dna polymerase III delta subunit
WS105_RS02340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WS105_RS02345	COG0268	Binds directly to 16S ribosomal RNA
WS105_RS02380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WS105_RS02395	COG1193	negative regulation of DNA recombination
WS105_RS02405	COG3118	belongs to the thioredoxin family
WS105_RS02410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WS105_RS02415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WS105_RS02425	COG2357	RelA SpoT domain protein
WS105_RS02430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WS105_RS02440	COG2239	Acts as a magnesium transporter
WS105_RS02445	COG0779	Required for maturation of 30S ribosomal subunits
WS105_RS02450	COG0195	Participates in both transcription termination and antitermination
WS105_RS02455	COG2740	Nucleic-acid-binding protein implicated in transcription termination
WS105_RS02465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WS105_RS02470	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WS105_RS02475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WS105_RS02490	COG0196	riboflavin kinase activity
WS105_RS02500	COG3142	Participates in the control of copper homeostasis
WS105_RS02505	COG1307	EDD domain protein, DegV family
WS105_RS02510	COG1307	EDD domain protein, DegV family
WS105_RS02515	COG0277	FAD linked oxidase domain protein
WS105_RS02520	COG4479	Belongs to the UPF0346 family
WS105_RS02525	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WS105_RS02530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WS105_RS02550	COG0758	DNA mediated transformation
WS105_RS02555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WS105_RS02560	COG4974	Belongs to the 'phage' integrase family
WS105_RS02575	COG2814	Major facilitator Superfamily
WS105_RS02585	COG0187	DNA topoisomerase II activity
WS105_RS02590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WS105_RS02610	COG1227	inorganic diphosphatase activity
WS105_RS02620	COG3448	diguanylate cyclase activity
WS105_RS02620	COG4175	Glycine betaine
WS105_RS02650	COG1011	Hydrolase
WS105_RS02670	COG5503	Protein of unknown function (DUF1447)
WS105_RS02680	COG0242	peptide deformylase activity
WS105_RS02685	COG4476	Belongs to the UPF0223 family
WS105_RS02690	COG0483	inositol monophosphate 1-phosphatase activity
WS105_RS02695	COG1217	gtp-binding protein TYPA
WS105_RS02700	COG0772	Belongs to the SEDS family
WS105_RS02705	COG4471	UPF0298 protein
WS105_RS02710	COG0742	ribosomal rna small subunit methyltransferase
WS105_RS02715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WS105_RS02720	COG3480	Lon protease (S16) C-terminal proteolytic domain
WS105_RS02725	COG0477	Major facilitator Superfamily
WS105_RS02730	COG0358	DNA primase activity
WS105_RS02735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WS105_RS02745	COG0745	RESPONSE REGULATOR receiver
WS105_RS02750	COG5002	protein histidine kinase activity
WS105_RS02755	COG0572	uridine kinase
WS105_RS02760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS105_RS02770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WS105_RS02775	COG0670	Belongs to the BI1 family
WS105_RS02795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WS105_RS02800	COG0237	dephospho-CoA kinase activity
WS105_RS02810	COG1484	DNA-dependent DNA replication
WS105_RS02825	COG0745	RESPONSE REGULATOR receiver
WS105_RS02855	COG1686	Belongs to the peptidase S11 family
WS105_RS02860	COG0626	cystathionine gamma-synthase activity
WS105_RS02885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WS105_RS02895	COG0488	(ABC) transporter
WS105_RS02945	COG1304	FMN binding
WS105_RS02960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WS105_RS02975	COG4690	dipeptidase activity
WS105_RS03060	COG1216	Glycosyl transferase, family 2
WS105_RS03065	COG1272	protein, Hemolysin III
WS105_RS03085	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WS105_RS03090	COG0439	Biotin carboxylase
WS105_RS03095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WS105_RS03115	COG3321	synthase
WS105_RS03115	COG0604	alcohol dehydrogenase
WS105_RS03130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WS105_RS03140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WS105_RS03145	COG2755	lipolytic protein G-D-S-L family
WS105_RS03145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
WS105_RS03160	COG0446	pyridine nucleotide-disulphide oxidoreductase
WS105_RS03180	COG0352	thiamine-phosphate diphosphorylase activity
WS105_RS03185	COG0351	phosphomethylpyrimidine kinase
WS105_RS03190	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
WS105_RS03195	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
WS105_RS03205	COG0584	glycerophosphoryl diester phosphodiesterase
WS105_RS03220	COG0561	phosphatase activity
WS105_RS03240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WS105_RS03250	COG1131	(ABC) transporter
WS105_RS03255	COG0537	adenosine 5'-monophosphoramidase activity
WS105_RS03265	COG0556	nucleotide-excision repair
WS105_RS03280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WS105_RS03475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WS105_RS03570	COG4974	Belongs to the 'phage' integrase family
WS105_RS03575	COG0116	Belongs to the methyltransferase superfamily
WS105_RS03580	COG3599	regulation of cell shape
WS105_RS03585	COG4474	Belongs to the UPF0398 family
WS105_RS03590	COG3331	DNA recombination
WS105_RS03605	COG3935	DnaD domain protein
WS105_RS03615	COG0017	Asparaginyl-tRNA synthetase
WS105_RS03625	COG1199	ATP-dependent helicase activity
WS105_RS03625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WS105_RS03630	COG2261	transglycosylase associated protein
WS105_RS03700	COG1304	FMN binding
WS105_RS03705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WS105_RS03710	COG0706	membrane insertase activity
WS105_RS03720	COG0105	UTP biosynthetic process
WS105_RS03725	COG0531	amino acid
WS105_RS03735	COG2855	membrane
WS105_RS03745	COG1215	transferase activity, transferring glycosyl groups
WS105_RS03755	COG0183	Belongs to the thiolase family
WS105_RS03765	COG0735	belongs to the Fur family
WS105_RS03775	COG0390	transport system, permease component
WS105_RS03780	COG4619	ABC transporter
WS105_RS03785	COG2267	carboxylic ester hydrolase activity
WS105_RS03790	COG2390	Transcriptional regulator
WS105_RS03800	COG1136	(ABC) transporter
WS105_RS03830	COG0095	Lipoate-protein ligase
WS105_RS03855	COG0741	lytic transglycosylase activity
WS105_RS03865	COG1694	Mazg nucleotide pyrophosphohydrolase
WS105_RS03870	COG1611	Belongs to the LOG family
WS105_RS03885	COG1609	Transcriptional regulator
WS105_RS03895	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WS105_RS03900	COG0151	Belongs to the GarS family
WS105_RS03905	COG0138	bifunctional purine biosynthesis protein purh
WS105_RS03910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WS105_RS03915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WS105_RS03925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WS105_RS03930	COG0047	phosphoribosylformylglycinamidine synthase activity
WS105_RS03935	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WS105_RS03940	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WS105_RS03945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WS105_RS03950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WS105_RS03955	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
WS105_RS03960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WS105_RS03965	COG1696	Membrane protein involved in D-alanine export
WS105_RS04010	COG3475	LICD family
WS105_RS04035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WS105_RS04040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WS105_RS04050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WS105_RS04055	COG2195	Cleaves the N-terminal amino acid of tripeptides
WS105_RS04060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WS105_RS04065	COG2384	SAM-dependent methyltransferase
WS105_RS04070	COG0457	Tetratricopeptide repeat
WS105_RS04095	COG2807	transmembrane transport
WS105_RS04100	COG4720	Psort location CytoplasmicMembrane, score
WS105_RS04105	COG0351	phosphomethylpyrimidine kinase
WS105_RS04115	COG1160	GTP binding
WS105_RS04120	COG0539	negative regulation of cytoplasmic translation
WS105_RS04125	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WS105_RS04145	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
WS105_RS04150	COG1187	pseudouridine synthase activity
WS105_RS04155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WS105_RS04160	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WS105_RS04165	COG0456	acetyltransferase
WS105_RS04175	COG2996	Protein conserved in bacteria
WS105_RS04185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WS105_RS04190	COG0149	triose-phosphate isomerase activity
WS105_RS04195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WS105_RS04210	COG2508	Transcriptional regulator
WS105_RS04225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WS105_RS04230	COG0587	DNA-directed DNA polymerase activity
WS105_RS04245	COG0488	(ABC) transporter
WS105_RS04250	COG0617	tRNA 3'-terminal CCA addition
WS105_RS04265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WS105_RS04275	COG1316	TRANSCRIPTIONal
WS105_RS04290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WS105_RS04305	COG0052	Belongs to the universal ribosomal protein uS2 family
WS105_RS04310	COG2827	Endonuclease containing a URI domain
WS105_RS04315	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WS105_RS04320	COG0204	Acyl-transferase
WS105_RS04325	COG3763	UPF0154 protein
WS105_RS04330	COG4224	UPF0291 protein
WS105_RS04335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WS105_RS04340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WS105_RS04340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
WS105_RS04345	COG1234	tRNA 3'-trailer cleavage
WS105_RS04360	COG0484	heat shock protein binding
WS105_RS04365	COG0443	Heat shock 70 kDa protein
WS105_RS04370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WS105_RS04375	COG1420	regulation of RNA biosynthetic process
WS105_RS04390	COG0463	Glycosyl transferase, family 2
WS105_RS04405	COG0024	Methionine aminopeptidase
WS105_RS04415	COG1682	transport, permease protein
WS105_RS04420	COG1388	LysM domain
WS105_RS04420	COG1134	teichoic acid transport
WS105_RS04430	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WS105_RS04435	COG2309	aminopeptidase activity
WS105_RS04440	COG1278	Cold shock
WS105_RS04450	COG2814	Major facilitator Superfamily
WS105_RS04460	COG1072	(Pantothenic acid kinase))
WS105_RS04465	COG3973	AAA domain
WS105_RS04470	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WS105_RS04475	COG1058	Belongs to the CinA family
WS105_RS04475	COG1546	Belongs to the CinA family
WS105_RS04480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WS105_RS04485	COG1426	Protein conserved in bacteria
WS105_RS04495	COG0612	Peptidase, M16
WS105_RS04500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WS105_RS04520	COG1070	Carbohydrate kinase
WS105_RS04525	COG3481	metal-dependent phosphohydrolase, HD sub domain
WS105_RS04530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WS105_RS04535	COG0420	3'-5' exonuclease activity
WS105_RS04545	COG3679	Belongs to the UPF0342 family
WS105_RS04550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WS105_RS04555	COG1438	arginine binding
WS105_RS04560	COG0018	arginyl-trna synthetase
WS105_RS04590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WS105_RS04605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WS105_RS04605	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WS105_RS04625	COG0667	Aldo Keto reductase
WS105_RS04630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WS105_RS04635	COG0167	dihydroorotate dehydrogenase activity
WS105_RS04640	COG3859	Proton-coupled thiamine transporter YuaJ
WS105_RS04650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WS105_RS04655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WS105_RS04660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WS105_RS04665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WS105_RS04670	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
WS105_RS04675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WS105_RS04695	COG4684	Psort location CytoplasmicMembrane, score
WS105_RS04710	COG0436	Aminotransferase
WS105_RS04720	COG1609	Transcriptional regulator
WS105_RS04745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WS105_RS04745	COG1321	iron dependent repressor
WS105_RS04755	COG3764	Sortase (surface protein transpeptidase)
WS105_RS04760	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
WS105_RS04765	COG0513	Belongs to the DEAD box helicase family
WS105_RS04770	COG0673	inositol 2-dehydrogenase activity
WS105_RS04775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WS105_RS04780	COG0501	Belongs to the peptidase M48B family
WS105_RS04785	COG1704	LemA family
WS105_RS04800	COG2153	protein acetylation
WS105_RS04820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WS105_RS04825	COG0562	UDP-galactopyranose mutase
WS105_RS04830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WS105_RS04835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WS105_RS04845	COG0505	Belongs to the CarA family
WS105_RS04855	COG0564	pseudouridine synthase activity
WS105_RS04865	COG1757	Na H antiporter
WS105_RS04870	COG1113	amino acid transport
WS105_RS04885	COG0126	phosphoglycerate kinase activity
WS105_RS04915	COG0737	Belongs to the 5'-nucleotidase family
WS105_RS04960	COG3716	PTS system mannose fructose sorbose family IID component
WS105_RS04965	COG3715	PTS system
WS105_RS05035	COG1185	polyribonucleotide nucleotidyltransferase activity
WS105_RS05045	COG0586	Pfam SNARE associated Golgi protein
WS105_RS05050	COG1758	RNA polymerase activity
WS105_RS05055	COG0194	GDP metabolic process
WS105_RS05060	COG0497	DNA recombination
WS105_RS05065	COG1438	arginine binding
WS105_RS05070	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
WS105_RS05080	COG1722	exodeoxyribonuclease VII activity
WS105_RS05085	COG1570	exodeoxyribonuclease VII activity
WS105_RS05090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WS105_RS05095	COG4720	Psort location CytoplasmicMembrane, score
WS105_RS05110	COG0363	glucosamine-6-phosphate deaminase activity
WS105_RS05115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WS105_RS05130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WS105_RS05140	COG1323	Belongs to the UPF0348 family
WS105_RS05150	COG0799	negative regulation of ribosome biogenesis
WS105_RS05155	COG1713	HD superfamily hydrolase involved in NAD metabolism
WS105_RS05160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WS105_RS05170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WS105_RS05175	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
WS105_RS05180	COG1181	Belongs to the D-alanine--D-alanine ligase family
WS105_RS05190	COG0531	amino acid
WS105_RS05195	COG0459	protein refolding
WS105_RS05200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WS105_RS05205	COG0488	(ABC) transporter
WS105_RS05210	COG0285	dihydrofolate synthase activity
WS105_RS05215	COG0525	valine-tRNA ligase activity
WS105_RS05220	COG1279	arginine transmembrane transporter activity
WS105_RS05225	COG0589	response to stress
WS105_RS05240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WS105_RS05270	COG2137	regulation of response to DNA damage stimulus
WS105_RS05280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WS105_RS05290	COG0581	inorganic phosphate transmembrane transporter activity
WS105_RS05295	COG0573	inorganic phosphate transmembrane transporter activity
WS105_RS05320	COG0393	Putative heavy-metal-binding
WS105_RS05325	COG0647	UMP catabolic process
WS105_RS05330	COG4470	Protein conserved in bacteria
WS105_RS05335	COG0737	Belongs to the 5'-nucleotidase family
WS105_RS05345	COG0006	proline dipeptidase activity
WS105_RS05365	COG0596	Alpha beta hydrolase
WS105_RS05370	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WS105_RS05375	COG1169	isochorismate synthase
WS105_RS05390	COG0531	amino acid
WS105_RS05400	COG2814	Major facilitator Superfamily
WS105_RS05410	COG1063	alcohol dehydrogenase
WS105_RS05415	COG0813	purine-nucleoside phosphorylase activity
WS105_RS05420	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WS105_RS05430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WS105_RS05440	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WS105_RS05445	COG1447	Phosphotransferase system cellobiose-specific component IIA
WS105_RS05450	COG1120	ATPase activity
WS105_RS05480	COG1686	Belongs to the peptidase S11 family
WS105_RS05485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WS105_RS05490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WS105_RS05495	COG2271	Major facilitator Superfamily
WS105_RS05525	COG0174	glutamine synthetase
WS105_RS05530	COG0789	Transcriptional regulator
WS105_RS05535	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WS105_RS05550	COG1940	carbohydrate kinase activity
WS105_RS05560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WS105_RS05580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WS105_RS05585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS105_RS05585	COG0072	phenylalanine-tRNA ligase activity
WS105_RS05590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WS105_RS05595	COG1733	regulation of RNA biosynthetic process
WS105_RS05605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WS105_RS05620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WS105_RS05625	COG0653	protein targeting
WS105_RS05640	COG0756	dUTP diphosphatase activity
WS105_RS05650	COG0791	NLP P60 protein
WS105_RS05660	COG0542	response to heat
WS105_RS05665	COG0604	alcohol dehydrogenase
WS105_RS05670	COG0028	Belongs to the TPP enzyme family
WS105_RS05675	COG3527	Alpha-acetolactate decarboxylase
WS105_RS05705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WS105_RS05720	COG0740	serine-type endopeptidase activity
WS105_RS05730	COG1481	regulation of sporulation
WS105_RS05735	COG0391	Required for morphogenesis under gluconeogenic growth conditions
WS105_RS05750	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WS105_RS05785	COG0101	tRNA pseudouridine synthase activity
WS105_RS05795	COG1122	ATPase activity
WS105_RS05800	COG1122	ATPase activity
WS105_RS05805	COG3594	Acyltransferase
WS105_RS05815	COG1252	NADH dehydrogenase
WS105_RS05820	COG0803	Belongs to the bacterial solute-binding protein 9 family
WS105_RS05825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WS105_RS05830	COG1121	(ABC) transporter
WS105_RS05845	COG0222	ribosome binding
WS105_RS05850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WS105_RS05855	COG0081	regulation of translation
WS105_RS05860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WS105_RS05865	COG0250	Participates in transcription elongation, termination and antitermination
WS105_RS05870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WS105_RS05885	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
WS105_RS05890	COG0215	cysteine-tRNA ligase activity
WS105_RS05905	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
WS105_RS05915	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WS105_RS05925	COG0203	ribosomal protein L17
WS105_RS05930	COG0202	RNA polymerase activity
WS105_RS05935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WS105_RS05940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WS105_RS05945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WS105_RS05950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WS105_RS05965	COG0200	Binds to the 23S rRNA
WS105_RS05970	COG1841	ribosomal large subunit assembly
WS105_RS05975	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WS105_RS05980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WS105_RS05985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WS105_RS05990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WS105_RS05995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WS105_RS06000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WS105_RS06005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WS105_RS06015	COG0255	Belongs to the universal ribosomal protein uL29 family
WS105_RS06020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WS105_RS06025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WS105_RS06030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WS105_RS06035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WS105_RS06040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WS105_RS06045	COG0089	rRNA binding
WS105_RS06060	COG0051	transcription antitermination factor activity, RNA binding
WS105_RS06090	COG1214	PFAM Peptidase M22, glycoprotease
WS105_RS06095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WS105_RS06115	COG3870	Protein conserved in bacteria
WS105_RS06120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WS105_RS06130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WS105_RS06135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WS105_RS06140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WS105_RS06150	COG2813	Specifically methylates the guanine in position
WS105_RS06185	COG1979	alcohol dehydrogenase
WS105_RS06190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WS105_RS06205	COG4463	regulation of RNA biosynthetic process
WS105_RS06225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WS105_RS06230	COG1428	Deoxynucleoside kinase
WS105_RS06240	COG1686	Belongs to the peptidase S11 family
WS105_RS06245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WS105_RS06255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WS105_RS06260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WS105_RS06265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WS105_RS06270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WS105_RS06275	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WS105_RS06285	COG2233	PERMEase
WS105_RS06295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WS105_RS06300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WS105_RS06305	COG0009	L-threonylcarbamoyladenylate synthase
WS105_RS06310	COG2890	protein-(glutamine-N5) methyltransferase activity
WS105_RS06315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WS105_RS06325	COG3442	glutamine amidotransferase
WS105_RS06330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WS105_RS06335	COG1482	cell wall glycoprotein biosynthetic process
WS105_RS06355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WS105_RS06380	COG1132	(ABC) transporter
WS105_RS06385	COG1132	(ABC) transporter
WS105_RS06390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WS105_RS06395	COG0588	phosphoglycerate mutase activity
WS105_RS06410	COG1573	uracil-dna glycosylase
WS105_RS06415	COG2610	gluconate transmembrane transporter activity
WS105_RS06420	COG0708	Exodeoxyribonuclease III
WS105_RS06425	COG1012	belongs to the aldehyde dehydrogenase family
WS105_RS06425	COG1454	alcohol dehydrogenase
WS105_RS06430	COG2235	arginine
WS105_RS06435	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WS105_RS06440	COG0531	amino acid
WS105_RS06450	COG3590	peptidase
WS105_RS06465	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
WS105_RS06470	COG2188	Transcriptional regulator
WS105_RS06475	COG1418	mRNA catabolic process
WS105_RS06505	COG0488	(ABC) transporter
WS105_RS06515	COG1121	(ABC) transporter
WS105_RS06525	COG1846	Transcriptional regulator
WS105_RS06530	COG3091	SprT-like family
WS105_RS06570	COG3104	oligopeptide transport
WS105_RS06580	COG5002	protein histidine kinase activity
WS105_RS06585	COG0745	RESPONSE REGULATOR receiver
WS105_RS06595	COG0012	GTP binding
WS105_RS06600	COG4481	Protein conserved in bacteria
WS105_RS06605	COG1475	DNA binding
WS105_RS06610	COG1192	Involved in chromosome partitioning
WS105_RS06615	COG0357	Ribosomal RNA small subunit methyltransferase G
WS105_RS06620	COG1194	a g-specific adenine glycosylase
WS105_RS06625	COG5002	protein histidine kinase activity
WS105_RS06630	COG0745	RESPONSE REGULATOR receiver
WS105_RS06635	COG0318	PFAM AMP-dependent synthetase and ligase
WS105_RS06640	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WS105_RS06650	COG1335	isochorismatase
WS105_RS06660	COG4443	Transcriptional Coactivator p15 (PC4)
WS105_RS06665	COG0252	asparaginase activity
WS105_RS06670	COG0531	amino acid
WS105_RS06680	COG2130	NADP-dependent
WS105_RS06690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WS105_RS06725	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WS105_RS06740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WS105_RS06745	COG1554	hydrolase, family 65, central catalytic
WS105_RS06750	COG2190	(PTS) system
WS105_RS06750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WS105_RS06750	COG1263	PTS System
WS105_RS06755	COG1263	PTS System
WS105_RS06755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WS105_RS06755	COG2190	(PTS) system
WS105_RS06760	COG2188	Transcriptional regulator
WS105_RS06770	COG1511	domain protein
WS105_RS06775	COG1959	2 iron, 2 sulfur cluster binding
WS105_RS06785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WS105_RS06790	COG3620	sequence-specific DNA binding
WS105_RS06810	COG0657	acetylesterase activity
WS105_RS06815	COG1113	amino acid transport
WS105_RS06820	COG0628	permease
WS105_RS06830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WS105_RS06835	COG0765	amino acid transport
WS105_RS06840	COG1126	abc transporter atp-binding protein
WS105_RS06850	COG0640	Transcriptional regulator
WS105_RS06855	COG2217	Heavy metal translocating P-type atpase
WS105_RS06865	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WS105_RS06870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WS105_RS06885	COG0028	Belongs to the TPP enzyme family
WS105_RS06895	COG4221	oxidoreductase activity
WS105_RS06900	COG0346	lactoylglutathione lyase activity
WS105_RS06905	COG0656	L-ascorbic acid biosynthetic process
WS105_RS06910	COG1733	regulation of RNA biosynthetic process
WS105_RS06915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WS105_RS06935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WS105_RS06940	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WS105_RS06945	COG1113	amino acid transport
WS105_RS06950	COG0569	domain protein
WS105_RS06960	COG0706	membrane insertase activity
WS105_RS06965	COG0594	ribonuclease P activity
WS105_RS06990	COG1266	CAAX protease self-immunity
WS105_RS07010	COG2369	cell adhesion
WS105_RS07020	COG3646	Phage regulatory protein