locus-tag	class	description
WS74_RS00005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WS74_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WS74_RS00020	COG2501	S4 domain
WS74_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WS74_RS00030	COG0187	DNA topoisomerase II activity
WS74_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WS74_RS00040	COG1368	sulfuric ester hydrolase activity
WS74_RS00115	COG1737	Transcriptional regulator
WS74_RS00120	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
WS74_RS00145	COG2233	PERMEase
WS74_RS00150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WS74_RS00155	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
WS74_RS00200	COG2252	PERMEase
WS74_RS00210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WS74_RS00215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WS74_RS00220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WS74_RS00225	COG2818	Glycosylase
WS74_RS00235	COG0495	leucyl-tRNA aminoacylation
WS74_RS00245	COG2244	polysaccharide biosynthetic process
WS74_RS00255	COG0531	amino acid
WS74_RS00265	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
WS74_RS00270	COG1074	ATP-dependent DNA helicase activity
WS74_RS00275	COG1064	alcohol dehydrogenase
WS74_RS00290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WS74_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WS74_RS00300	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WS74_RS00305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WS74_RS00310	COG4493	Belongs to the UPF0637 family
WS74_RS00315	COG0360	Binds together with S18 to 16S ribosomal RNA
WS74_RS00320	COG0629	single-stranded DNA binding
WS74_RS00325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WS74_RS00345	COG0745	RESPONSE REGULATOR receiver
WS74_RS00350	COG5002	protein histidine kinase activity
WS74_RS00365	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
WS74_RS00370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WS74_RS00380	COG1078	dGTPase activity
WS74_RS00385	COG0561	phosphatase activity
WS74_RS00390	COG3343	RNA polymerase activity
WS74_RS00395	COG0504	CTP synthase activity
WS74_RS00400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WS74_RS00420	COG2337	Toxic component of a toxin-antitoxin (TA) module
WS74_RS00425	COG3973	AAA domain
WS74_RS00435	COG0248	Ppx GppA phosphatase
WS74_RS00460	COG0194	GDP metabolic process
WS74_RS00480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WS74_RS00485	COG0765	amino acid transport
WS74_RS00490	COG0765	amino acid transport
WS74_RS00495	COG4166	transmembrane transport
WS74_RS00500	COG4166	transmembrane transport
WS74_RS00505	COG0601	transmembrane transport
WS74_RS00510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WS74_RS00515	COG0444	Belongs to the ABC transporter superfamily
WS74_RS00520	COG4608	Belongs to the ABC transporter superfamily
WS74_RS00530	COG0359	binds to the 23S rRNA
WS74_RS00535	COG0305	Participates in initiation and elongation during chromosome replication
WS74_RS00540	COG2814	Major facilitator Superfamily
WS74_RS00555	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WS74_RS00570	COG0588	phosphoglycerate mutase activity
WS74_RS00575	COG1134	teichoic acid transport
WS74_RS00575	COG1388	LysM domain
WS74_RS00590	COG0586	Pfam SNARE associated Golgi protein
WS74_RS00605	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WS74_RS00610	COG1077	Cell shape determining protein MreB Mrl
WS74_RS00620	COG0772	Belongs to the SEDS family
WS74_RS00625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WS74_RS00635	COG0561	phosphatase activity
WS74_RS00640	COG0577	efflux transmembrane transporter activity
WS74_RS00640	COG1136	(ABC) transporter
WS74_RS00650	COG2188	Transcriptional regulator
WS74_RS00655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WS74_RS00670	COG2252	PERMEase
WS74_RS00680	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
WS74_RS00700	COG0561	phosphatase activity
WS74_RS00705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WS74_RS00710	COG4589	Belongs to the CDS family
WS74_RS00715	COG0750	zinc metalloprotease
WS74_RS00720	COG0442	prolyl-tRNA aminoacylation
WS74_RS00725	COG2176	DNA-directed DNA polymerase activity
WS74_RS00730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WS74_RS00765	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
WS74_RS00790	COG2183	response to ionizing radiation
WS74_RS00800	COG2217	Heavy metal translocating P-type atpase
WS74_RS00935	COG3706	GGDEF domain
WS74_RS00940	COG0716	FMN binding
WS74_RS00945	COG2199	diguanylate cyclase activity
WS74_RS00970	COG1869	D-ribose catabolic process
WS74_RS00985	COG0668	transmembrane transport
WS74_RS00990	COG4975	Glucose uptake
WS74_RS00995	COG0166	Belongs to the GPI family
WS74_RS01000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WS74_RS01005	COG1302	Protein conserved in bacteria
WS74_RS01010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WS74_RS01020	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WS74_RS01025	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WS74_RS01035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WS74_RS01040	COG0049	tRNA binding
WS74_RS01045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WS74_RS01050	COG0673	inositol 2-dehydrogenase activity
WS74_RS01055	COG3842	ATPase activity
WS74_RS01065	COG1177	transmembrane transport
WS74_RS01070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WS74_RS01075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WS74_RS01080	COG1950	PFAM Membrane protein of
WS74_RS01085	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
WS74_RS01090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WS74_RS01100	COG0492	ferredoxin-NADP+ reductase activity
WS74_RS01115	COG0149	triose-phosphate isomerase activity
WS74_RS01130	COG0557	exoribonuclease II activity
WS74_RS01135	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WS74_RS01140	COG0765	amino acid transport
WS74_RS01145	COG1126	abc transporter atp-binding protein
WS74_RS01150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WS74_RS01155	COG0280	phosphate acetyltransferase
WS74_RS01160	COG0802	atpase or kinase
WS74_RS01175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WS74_RS01200	COG0540	Belongs to the ATCase OTCase family
WS74_RS01210	COG0505	Belongs to the CarA family
WS74_RS01215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WS74_RS01220	COG0284	orotidine-5'-phosphate decarboxylase activity
WS74_RS01225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WS74_RS01230	COG0438	transferase activity, transferring glycosyl groups
WS74_RS01235	COG0438	transferase activity, transferring glycosyl groups
WS74_RS01245	COG1368	sulfuric ester hydrolase activity
WS74_RS01265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS74_RS01265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS74_RS01270	COG0025	NhaP-type Na H and K H
WS74_RS01275	COG0084	hydrolase, TatD family'
WS74_RS01280	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
WS74_RS01285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WS74_RS01290	COG1253	flavin adenine dinucleotide binding
WS74_RS01295	COG4466	Protein conserved in bacteria
WS74_RS01300	COG2131	deaminase
WS74_RS01310	COG1316	TRANSCRIPTIONal
WS74_RS01315	COG1983	PspC domain protein
WS74_RS01320	COG1968	undecaprenyl-diphosphatase activity
WS74_RS01340	COG0193	aminoacyl-tRNA hydrolase activity
WS74_RS01345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WS74_RS01350	COG2244	polysaccharide biosynthetic process
WS74_RS01355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WS74_RS01380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WS74_RS01385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WS74_RS01515	COG1271	oxidase subunit
WS74_RS01520	COG1294	oxidase, subunit
WS74_RS01525	COG4988	ABC transporter
WS74_RS01530	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WS74_RS01535	COG1705	Flagellar rod assembly protein muramidase FlgJ
WS74_RS01565	COG0494	nUDIX hydrolase
WS74_RS01575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WS74_RS01590	COG1388	LysM domain
WS74_RS01600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WS74_RS01605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WS74_RS01610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WS74_RS01620	COG4120	Belongs to the binding-protein-dependent transport system permease family
WS74_RS01625	COG1116	anion transmembrane transporter activity
WS74_RS01645	COG2003	Belongs to the UPF0758 family
WS74_RS01650	COG1077	Cell shape determining protein MreB Mrl
WS74_RS01670	COG0765	amino acid transport
WS74_RS01685	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WS74_RS01710	COG0833	amino acid
WS74_RS01720	COG2264	protein methyltransferase activity
WS74_RS01725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WS74_RS01730	COG2001	Belongs to the MraZ family
WS74_RS01735	COG0275	rRNA processing
WS74_RS01745	COG0768	penicillin binding
WS74_RS01755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WS74_RS01760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WS74_RS01770	COG0849	cell division
WS74_RS01780	COG1799	cell septum assembly
WS74_RS01785	COG0762	integral membrane protein
WS74_RS01790	COG2302	S4 RNA-binding domain
WS74_RS01795	COG3599	regulation of cell shape
WS74_RS01800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WS74_RS01815	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WS74_RS01820	COG0217	transcriptional regulatory protein
WS74_RS01825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WS74_RS01830	COG1459	type II secretion system
WS74_RS01835	COG4537	Required for transformation and DNA binding
WS74_RS01865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WS74_RS01870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WS74_RS01870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WS74_RS01880	COG2815	serine threonine protein kinase
WS74_RS01880	COG0515	serine threonine protein kinase
WS74_RS01885	COG1162	GTPase activity
WS74_RS01890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WS74_RS01900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WS74_RS01910	COG1461	Dihydroxyacetone kinase
WS74_RS01915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WS74_RS01920	COG0416	fatty acid biosynthetic process
WS74_RS01925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WS74_RS01930	COG0571	ribonuclease III activity
WS74_RS01935	COG1196	nuclear chromosome segregation
WS74_RS01940	COG0552	protein localization to endoplasmic reticulum
WS74_RS01945	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
WS74_RS01950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WS74_RS01955	COG0228	four-way junction DNA binding
WS74_RS01960	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WS74_RS01965	COG0336	Belongs to the RNA methyltransferase TrmD family
WS74_RS01970	COG0335	large ribosomal subunit rRNA binding
WS74_RS01975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WS74_RS01980	COG1942	4-Oxalocrotonate Tautomerase
WS74_RS01985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WS74_RS01990	COG0494	nUDIX hydrolase
WS74_RS01995	COG1428	Deoxynucleoside kinase
WS74_RS02005	COG0561	phosphatase activity
WS74_RS02030	COG4862	establishment of competence for transformation
WS74_RS02050	COG0006	proline dipeptidase activity
WS74_RS02055	COG1609	Transcriptional regulator
WS74_RS02105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WS74_RS02110	COG3425	synthase
WS74_RS02120	COG0860	N-Acetylmuramoyl-L-alanine amidase
WS74_RS02125	COG0124	histidyl-tRNA synthetase
WS74_RS02130	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WS74_RS02135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WS74_RS02145	COG1610	YqeY-like protein
WS74_RS02150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WS74_RS02155	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WS74_RS02160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WS74_RS02165	COG1381	Involved in DNA repair and RecF pathway recombination
WS74_RS02170	COG0752	glycyl-tRNA synthetase alpha subunit
WS74_RS02175	COG0751	glycine-tRNA ligase activity
WS74_RS02190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WS74_RS02195	COG1620	l-lactate permease
WS74_RS02205	COG2706	6-phosphogluconolactonase activity
WS74_RS02215	COG1674	ftsk spoiiie
WS74_RS02220	COG4152	abc transporter atp-binding protein
WS74_RS02225	COG1668	transmembrane transport
WS74_RS02230	COG0584	glycerophosphoryl diester phosphodiesterase
WS74_RS02235	COG0322	excinuclease ABC activity
WS74_RS02250	COG1739	Uncharacterized protein family UPF0029
WS74_RS02260	COG0517	IMP dehydrogenase activity
WS74_RS02260	COG0516	GMP reductase activity
WS74_RS02265	COG0632	four-way junction helicase activity
WS74_RS02270	COG2255	four-way junction helicase activity
WS74_RS02310	COG1862	Preprotein translocase
WS74_RS02315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WS74_RS02320	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WS74_RS02325	COG0513	Belongs to the DEAD box helicase family
WS74_RS02330	COG0110	maltose O-acetyltransferase activity
WS74_RS02335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WS74_RS02350	COG3906	Belongs to the UPF0473 family
WS74_RS02355	COG3906	Belongs to the UPF0473 family
WS74_RS02360	COG1555	photosystem II stabilization
WS74_RS02365	COG2333	competence protein COMEC
WS74_RS02365	COG0658	competence protein
WS74_RS02370	COG1466	dna polymerase III delta subunit
WS74_RS02375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WS74_RS02380	COG0268	Binds directly to 16S ribosomal RNA
WS74_RS02415	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WS74_RS02430	COG1193	negative regulation of DNA recombination
WS74_RS02440	COG3118	belongs to the thioredoxin family
WS74_RS02445	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WS74_RS02450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WS74_RS02460	COG2357	RelA SpoT domain protein
WS74_RS02465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WS74_RS02470	COG0564	pseudouridine synthase activity
WS74_RS02475	COG2239	Acts as a magnesium transporter
WS74_RS02480	COG0779	Required for maturation of 30S ribosomal subunits
WS74_RS02485	COG0195	Participates in both transcription termination and antitermination
WS74_RS02490	COG2740	Nucleic-acid-binding protein implicated in transcription termination
WS74_RS02500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WS74_RS02505	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WS74_RS02510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WS74_RS02515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WS74_RS02525	COG0196	riboflavin kinase activity
WS74_RS02535	COG3142	Participates in the control of copper homeostasis
WS74_RS02540	COG1307	EDD domain protein, DegV family
WS74_RS02545	COG1307	EDD domain protein, DegV family
WS74_RS02550	COG0277	FAD linked oxidase domain protein
WS74_RS02555	COG4479	Belongs to the UPF0346 family
WS74_RS02560	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WS74_RS02565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WS74_RS02580	COG0758	DNA mediated transformation
WS74_RS02585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WS74_RS02590	COG4974	Belongs to the 'phage' integrase family
WS74_RS02605	COG2814	Major facilitator Superfamily
WS74_RS02615	COG0187	DNA topoisomerase II activity
WS74_RS02620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WS74_RS02640	COG1227	inorganic diphosphatase activity
WS74_RS02650	COG3448	diguanylate cyclase activity
WS74_RS02650	COG4175	Glycine betaine
WS74_RS02680	COG1011	Hydrolase
WS74_RS02700	COG5503	Protein of unknown function (DUF1447)
WS74_RS02710	COG0242	peptide deformylase activity
WS74_RS02715	COG4476	Belongs to the UPF0223 family
WS74_RS02720	COG0483	inositol monophosphate 1-phosphatase activity
WS74_RS02725	COG1217	gtp-binding protein TYPA
WS74_RS02730	COG0772	Belongs to the SEDS family
WS74_RS02735	COG4471	UPF0298 protein
WS74_RS02740	COG0742	ribosomal rna small subunit methyltransferase
WS74_RS02745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WS74_RS02750	COG3480	Lon protease (S16) C-terminal proteolytic domain
WS74_RS02755	COG0477	Major facilitator Superfamily
WS74_RS02770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WS74_RS02780	COG0745	RESPONSE REGULATOR receiver
WS74_RS02785	COG5002	protein histidine kinase activity
WS74_RS02790	COG0572	uridine kinase
WS74_RS02795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS74_RS02805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WS74_RS02810	COG0670	Belongs to the BI1 family
WS74_RS02830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WS74_RS02835	COG0237	dephospho-CoA kinase activity
WS74_RS02845	COG1484	DNA-dependent DNA replication
WS74_RS02860	COG0745	RESPONSE REGULATOR receiver
WS74_RS02865	COG5002	protein histidine kinase activity
WS74_RS02890	COG1686	Belongs to the peptidase S11 family
WS74_RS02895	COG0626	cystathionine gamma-synthase activity
WS74_RS02920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WS74_RS02930	COG0488	(ABC) transporter
WS74_RS02980	COG1304	FMN binding
WS74_RS02995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WS74_RS03010	COG4690	dipeptidase activity
WS74_RS03095	COG1216	Glycosyl transferase, family 2
WS74_RS03100	COG1272	protein, Hemolysin III
WS74_RS03120	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WS74_RS03125	COG0439	Biotin carboxylase
WS74_RS03130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WS74_RS03150	COG3321	synthase
WS74_RS03150	COG0604	alcohol dehydrogenase
WS74_RS03165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WS74_RS03175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WS74_RS03180	COG2755	lipolytic protein G-D-S-L family
WS74_RS03180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
WS74_RS03195	COG0446	pyridine nucleotide-disulphide oxidoreductase
WS74_RS03215	COG0352	thiamine-phosphate diphosphorylase activity
WS74_RS03220	COG0351	phosphomethylpyrimidine kinase
WS74_RS03225	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
WS74_RS03230	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
WS74_RS03240	COG0584	glycerophosphoryl diester phosphodiesterase
WS74_RS03255	COG0561	phosphatase activity
WS74_RS03275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WS74_RS03285	COG1131	(ABC) transporter
WS74_RS03290	COG0537	adenosine 5'-monophosphoramidase activity
WS74_RS03300	COG0556	nucleotide-excision repair
WS74_RS03315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WS74_RS03350	COG3599	regulation of cell shape
WS74_RS03360	COG3331	DNA recombination
WS74_RS03375	COG3935	DnaD domain protein
WS74_RS03385	COG0017	Asparaginyl-tRNA synthetase
WS74_RS03395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WS74_RS03395	COG1199	ATP-dependent helicase activity
WS74_RS03400	COG2261	transglycosylase associated protein
WS74_RS03470	COG1304	FMN binding
WS74_RS03475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WS74_RS03480	COG0706	membrane insertase activity
WS74_RS03490	COG0105	UTP biosynthetic process
WS74_RS03495	COG0531	amino acid
WS74_RS03505	COG2855	membrane
WS74_RS03515	COG1215	transferase activity, transferring glycosyl groups
WS74_RS03525	COG0183	Belongs to the thiolase family
WS74_RS03535	COG0735	belongs to the Fur family
WS74_RS03545	COG0390	transport system, permease component
WS74_RS03550	COG4619	ABC transporter
WS74_RS03555	COG2267	carboxylic ester hydrolase activity
WS74_RS03560	COG2390	Transcriptional regulator
WS74_RS03570	COG1136	(ABC) transporter
WS74_RS03600	COG0095	Lipoate-protein ligase
WS74_RS03605	COG0366	Alpha amylase catalytic
WS74_RS03625	COG0741	lytic transglycosylase activity
WS74_RS03635	COG1694	Mazg nucleotide pyrophosphohydrolase
WS74_RS03640	COG1611	Belongs to the LOG family
WS74_RS03655	COG1609	Transcriptional regulator
WS74_RS03665	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WS74_RS03670	COG0151	Belongs to the GarS family
WS74_RS03675	COG0138	bifunctional purine biosynthesis protein purh
WS74_RS03680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WS74_RS03685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WS74_RS03695	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WS74_RS03705	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WS74_RS03710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WS74_RS03715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WS74_RS03720	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WS74_RS03725	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
WS74_RS03730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WS74_RS03735	COG1696	Membrane protein involved in D-alanine export
WS74_RS03780	COG3475	LICD family
WS74_RS03805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WS74_RS03810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WS74_RS03825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WS74_RS03830	COG2195	Cleaves the N-terminal amino acid of tripeptides
WS74_RS03835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WS74_RS03840	COG2384	SAM-dependent methyltransferase
WS74_RS03845	COG0457	Tetratricopeptide repeat
WS74_RS03870	COG2807	transmembrane transport
WS74_RS03875	COG4720	Psort location CytoplasmicMembrane, score
WS74_RS03880	COG0351	phosphomethylpyrimidine kinase
WS74_RS03890	COG1160	GTP binding
WS74_RS03895	COG0539	negative regulation of cytoplasmic translation
WS74_RS03900	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WS74_RS03910	COG0514	ATP-dependent DNA helicase (RecQ)
WS74_RS03920	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
WS74_RS03925	COG1187	pseudouridine synthase activity
WS74_RS03930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WS74_RS03935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WS74_RS03940	COG0456	acetyltransferase
WS74_RS03950	COG2996	Protein conserved in bacteria
WS74_RS03960	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WS74_RS03965	COG0149	triose-phosphate isomerase activity
WS74_RS03970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WS74_RS03980	COG3835	regulator
WS74_RS03985	COG0475	glutathione-regulated potassium exporter activity
WS74_RS03995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WS74_RS04000	COG0587	DNA-directed DNA polymerase activity
WS74_RS04015	COG0488	(ABC) transporter
WS74_RS04020	COG0617	tRNA 3'-terminal CCA addition
WS74_RS04035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WS74_RS04060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WS74_RS04075	COG0052	Belongs to the universal ribosomal protein uS2 family
WS74_RS04080	COG2827	Endonuclease containing a URI domain
WS74_RS04085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WS74_RS04090	COG0204	Acyl-transferase
WS74_RS04095	COG3763	UPF0154 protein
WS74_RS04100	COG4224	UPF0291 protein
WS74_RS04105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WS74_RS04110	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
WS74_RS04110	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WS74_RS04115	COG1234	tRNA 3'-trailer cleavage
WS74_RS04130	COG0484	heat shock protein binding
WS74_RS04135	COG0443	Heat shock 70 kDa protein
WS74_RS04140	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WS74_RS04145	COG1420	regulation of RNA biosynthetic process
WS74_RS04160	COG0463	Glycosyl transferase, family 2
WS74_RS04175	COG0024	Methionine aminopeptidase
WS74_RS04185	COG1682	transport, permease protein
WS74_RS04190	COG1134	teichoic acid transport
WS74_RS04190	COG1388	LysM domain
WS74_RS04200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WS74_RS04205	COG2309	aminopeptidase activity
WS74_RS04210	COG1278	Cold shock
WS74_RS04220	COG2814	Major facilitator Superfamily
WS74_RS04230	COG1072	(Pantothenic acid kinase))
WS74_RS04235	COG3973	AAA domain
WS74_RS04240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WS74_RS04245	COG1546	Belongs to the CinA family
WS74_RS04245	COG1058	Belongs to the CinA family
WS74_RS04250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WS74_RS04255	COG1426	Protein conserved in bacteria
WS74_RS04265	COG0612	Peptidase, M16
WS74_RS04270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WS74_RS04380	COG1783	phage Terminase large subunit
WS74_RS04515	COG3646	Phage regulatory protein
WS74_RS04540	COG1396	sequence-specific DNA binding
WS74_RS04560	COG4974	Belongs to the 'phage' integrase family
WS74_RS04565	COG1070	Carbohydrate kinase
WS74_RS04570	COG3481	metal-dependent phosphohydrolase, HD sub domain
WS74_RS04575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WS74_RS04580	COG0420	3'-5' exonuclease activity
WS74_RS04590	COG3679	Belongs to the UPF0342 family
WS74_RS04595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WS74_RS04600	COG1438	arginine binding
WS74_RS04605	COG0018	arginyl-trna synthetase
WS74_RS04620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WS74_RS04630	COG1597	lipid kinase activity
WS74_RS04635	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WS74_RS04645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WS74_RS04650	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WS74_RS04650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WS74_RS04670	COG0667	Aldo Keto reductase
WS74_RS04675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WS74_RS04680	COG0167	dihydroorotate dehydrogenase activity
WS74_RS04685	COG3859	Proton-coupled thiamine transporter YuaJ
WS74_RS04695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WS74_RS04700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WS74_RS04705	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WS74_RS04710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WS74_RS04715	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
WS74_RS04720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WS74_RS04745	COG0436	Aminotransferase
WS74_RS04755	COG0436	Aminotransferase
WS74_RS04765	COG1609	Transcriptional regulator
WS74_RS04790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WS74_RS04790	COG1321	iron dependent repressor
WS74_RS04800	COG3764	Sortase (surface protein transpeptidase)
WS74_RS04805	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
WS74_RS04810	COG0513	Belongs to the DEAD box helicase family
WS74_RS04815	COG0673	inositol 2-dehydrogenase activity
WS74_RS04820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WS74_RS04825	COG0501	Belongs to the peptidase M48B family
WS74_RS04830	COG1704	LemA family
WS74_RS04845	COG2153	protein acetylation
WS74_RS04865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WS74_RS04870	COG0562	UDP-galactopyranose mutase
WS74_RS04875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WS74_RS04880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WS74_RS04890	COG0505	Belongs to the CarA family
WS74_RS04900	COG0564	pseudouridine synthase activity
WS74_RS04910	COG1757	Na H antiporter
WS74_RS04915	COG1113	amino acid transport
WS74_RS04930	COG0126	phosphoglycerate kinase activity
WS74_RS04960	COG0737	Belongs to the 5'-nucleotidase family
WS74_RS05005	COG3716	PTS system mannose fructose sorbose family IID component
WS74_RS05010	COG3715	PTS system
WS74_RS05090	COG1185	polyribonucleotide nucleotidyltransferase activity
WS74_RS05100	COG0586	Pfam SNARE associated Golgi protein
WS74_RS05105	COG1758	RNA polymerase activity
WS74_RS05110	COG0194	GDP metabolic process
WS74_RS05115	COG0497	DNA recombination
WS74_RS05120	COG1438	arginine binding
WS74_RS05125	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
WS74_RS05135	COG1722	exodeoxyribonuclease VII activity
WS74_RS05140	COG1570	exodeoxyribonuclease VII activity
WS74_RS05145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WS74_RS05150	COG4720	Psort location CytoplasmicMembrane, score
WS74_RS05165	COG0363	glucosamine-6-phosphate deaminase activity
WS74_RS05170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WS74_RS05185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WS74_RS05195	COG1323	Belongs to the UPF0348 family
WS74_RS05205	COG0799	negative regulation of ribosome biogenesis
WS74_RS05210	COG1713	HD superfamily hydrolase involved in NAD metabolism
WS74_RS05215	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WS74_RS05225	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WS74_RS05230	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
WS74_RS05235	COG1181	Belongs to the D-alanine--D-alanine ligase family
WS74_RS05245	COG0531	amino acid
WS74_RS05250	COG0459	protein refolding
WS74_RS05255	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WS74_RS05260	COG0488	(ABC) transporter
WS74_RS05265	COG0285	dihydrofolate synthase activity
WS74_RS05270	COG0525	valine-tRNA ligase activity
WS74_RS05275	COG1279	arginine transmembrane transporter activity
WS74_RS05280	COG0589	response to stress
WS74_RS05295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WS74_RS05320	COG3557	Belongs to the UPF0374 family
WS74_RS05325	COG2137	regulation of response to DNA damage stimulus
WS74_RS05335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WS74_RS05345	COG0581	inorganic phosphate transmembrane transporter activity
WS74_RS05350	COG0573	inorganic phosphate transmembrane transporter activity
WS74_RS05375	COG0393	Putative heavy-metal-binding
WS74_RS05380	COG0647	UMP catabolic process
WS74_RS05385	COG4470	Protein conserved in bacteria
WS74_RS05390	COG0737	Belongs to the 5'-nucleotidase family
WS74_RS05400	COG0006	proline dipeptidase activity
WS74_RS05420	COG0596	Alpha beta hydrolase
WS74_RS05425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WS74_RS05430	COG1169	isochorismate synthase
WS74_RS05445	COG0531	amino acid
WS74_RS05455	COG2814	Major facilitator Superfamily
WS74_RS05465	COG1063	alcohol dehydrogenase
WS74_RS05470	COG0813	purine-nucleoside phosphorylase activity
WS74_RS05475	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WS74_RS05485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WS74_RS05495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WS74_RS05500	COG1447	Phosphotransferase system cellobiose-specific component IIA
WS74_RS05505	COG1120	ATPase activity
WS74_RS05535	COG1686	Belongs to the peptidase S11 family
WS74_RS05540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WS74_RS05545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WS74_RS05550	COG2271	Major facilitator Superfamily
WS74_RS05580	COG0174	glutamine synthetase
WS74_RS05585	COG0789	Transcriptional regulator
WS74_RS05590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WS74_RS05605	COG1940	carbohydrate kinase activity
WS74_RS05615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WS74_RS05620	COG0768	penicillin binding
WS74_RS05635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WS74_RS05640	COG0072	phenylalanine-tRNA ligase activity
WS74_RS05640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WS74_RS05645	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WS74_RS05650	COG1733	regulation of RNA biosynthetic process
WS74_RS05660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WS74_RS05675	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WS74_RS05680	COG0653	protein targeting
WS74_RS05695	COG0756	dUTP diphosphatase activity
WS74_RS05705	COG0791	NLP P60 protein
WS74_RS05715	COG0542	response to heat
WS74_RS05720	COG0604	alcohol dehydrogenase
WS74_RS05725	COG0028	Belongs to the TPP enzyme family
WS74_RS05730	COG3527	Alpha-acetolactate decarboxylase
WS74_RS05760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WS74_RS05775	COG0740	serine-type endopeptidase activity
WS74_RS05785	COG1481	regulation of sporulation
WS74_RS05790	COG0391	Required for morphogenesis under gluconeogenic growth conditions
WS74_RS05805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WS74_RS05840	COG0101	tRNA pseudouridine synthase activity
WS74_RS05850	COG1122	ATPase activity
WS74_RS05855	COG1122	ATPase activity
WS74_RS05860	COG3594	Acyltransferase
WS74_RS05870	COG1252	NADH dehydrogenase
WS74_RS05875	COG0803	Belongs to the bacterial solute-binding protein 9 family
WS74_RS05880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WS74_RS05885	COG1121	(ABC) transporter
WS74_RS05900	COG0222	ribosome binding
WS74_RS05905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WS74_RS05910	COG0081	regulation of translation
WS74_RS05915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WS74_RS05920	COG0250	Participates in transcription elongation, termination and antitermination
WS74_RS05925	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WS74_RS05935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WS74_RS05940	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
WS74_RS05945	COG0215	cysteine-tRNA ligase activity
WS74_RS05960	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
WS74_RS05970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WS74_RS05980	COG0203	ribosomal protein L17
WS74_RS05985	COG0202	RNA polymerase activity
WS74_RS05990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WS74_RS05995	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WS74_RS06000	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WS74_RS06005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WS74_RS06020	COG0200	Binds to the 23S rRNA
WS74_RS06025	COG1841	ribosomal large subunit assembly
WS74_RS06030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WS74_RS06035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WS74_RS06040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WS74_RS06045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WS74_RS06050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WS74_RS06055	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WS74_RS06060	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WS74_RS06070	COG0255	Belongs to the universal ribosomal protein uL29 family
WS74_RS06075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WS74_RS06080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WS74_RS06085	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WS74_RS06090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WS74_RS06095	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WS74_RS06100	COG0089	rRNA binding
WS74_RS06110	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WS74_RS06115	COG0051	transcription antitermination factor activity, RNA binding
WS74_RS06145	COG1214	PFAM Peptidase M22, glycoprotease
WS74_RS06150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WS74_RS06170	COG3870	Protein conserved in bacteria
WS74_RS06175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WS74_RS06185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WS74_RS06190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WS74_RS06195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WS74_RS06205	COG2813	Specifically methylates the guanine in position
WS74_RS06240	COG1979	alcohol dehydrogenase
WS74_RS06245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WS74_RS06250	COG0085	RNA polymerase activity
WS74_RS06260	COG4463	regulation of RNA biosynthetic process
WS74_RS06280	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WS74_RS06285	COG1428	Deoxynucleoside kinase
WS74_RS06295	COG1686	Belongs to the peptidase S11 family
WS74_RS06300	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WS74_RS06305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WS74_RS06310	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WS74_RS06315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WS74_RS06320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WS74_RS06325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WS74_RS06330	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WS74_RS06340	COG2233	PERMEase
WS74_RS06350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WS74_RS06355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WS74_RS06360	COG0009	L-threonylcarbamoyladenylate synthase
WS74_RS06365	COG2890	protein-(glutamine-N5) methyltransferase activity
WS74_RS06370	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WS74_RS06375	COG1435	thymidine kinase activity
WS74_RS06380	COG3442	glutamine amidotransferase
WS74_RS06385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WS74_RS06390	COG1482	cell wall glycoprotein biosynthetic process
WS74_RS06410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WS74_RS06435	COG1132	(ABC) transporter
WS74_RS06440	COG1132	(ABC) transporter
WS74_RS06445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WS74_RS06450	COG0588	phosphoglycerate mutase activity
WS74_RS06465	COG1573	uracil-dna glycosylase
WS74_RS06470	COG2610	gluconate transmembrane transporter activity
WS74_RS06475	COG0708	Exodeoxyribonuclease III
WS74_RS06480	COG1454	alcohol dehydrogenase
WS74_RS06480	COG1012	belongs to the aldehyde dehydrogenase family
WS74_RS06485	COG2235	arginine
WS74_RS06490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WS74_RS06495	COG0531	amino acid
WS74_RS06505	COG3590	peptidase
WS74_RS06520	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
WS74_RS06525	COG2188	Transcriptional regulator
WS74_RS06530	COG1418	mRNA catabolic process
WS74_RS06560	COG0488	(ABC) transporter
WS74_RS06570	COG1121	(ABC) transporter
WS74_RS06580	COG1846	Transcriptional regulator
WS74_RS06585	COG3091	SprT-like family
WS74_RS06625	COG3104	oligopeptide transport
WS74_RS06635	COG5002	protein histidine kinase activity
WS74_RS06640	COG0745	RESPONSE REGULATOR receiver
WS74_RS06650	COG0012	GTP binding
WS74_RS06655	COG4481	Protein conserved in bacteria
WS74_RS06660	COG1475	DNA binding
WS74_RS06665	COG1192	Involved in chromosome partitioning
WS74_RS06670	COG0357	Ribosomal RNA small subunit methyltransferase G
WS74_RS06675	COG1194	a g-specific adenine glycosylase
WS74_RS06680	COG5002	protein histidine kinase activity
WS74_RS06685	COG0745	RESPONSE REGULATOR receiver
WS74_RS06690	COG0318	PFAM AMP-dependent synthetase and ligase
WS74_RS06695	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WS74_RS06705	COG1335	isochorismatase
WS74_RS06715	COG4443	Transcriptional Coactivator p15 (PC4)
WS74_RS06720	COG0252	asparaginase activity
WS74_RS06725	COG0531	amino acid
WS74_RS06735	COG2130	NADP-dependent
WS74_RS06745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WS74_RS06780	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WS74_RS06795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WS74_RS06800	COG1554	hydrolase, family 65, central catalytic
WS74_RS06805	COG2190	(PTS) system
WS74_RS06805	COG1263	PTS System
WS74_RS06805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WS74_RS06810	COG1263	PTS System
WS74_RS06810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WS74_RS06810	COG2190	(PTS) system
WS74_RS06815	COG2188	Transcriptional regulator
WS74_RS06820	COG1511	domain protein
WS74_RS06825	COG1959	2 iron, 2 sulfur cluster binding
WS74_RS06835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WS74_RS06840	COG3620	sequence-specific DNA binding
WS74_RS06860	COG0657	acetylesterase activity
WS74_RS06865	COG1113	amino acid transport
WS74_RS06870	COG0628	permease
WS74_RS06880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WS74_RS06885	COG0765	amino acid transport
WS74_RS06890	COG1126	abc transporter atp-binding protein
WS74_RS06900	COG0640	Transcriptional regulator
WS74_RS06905	COG2217	Heavy metal translocating P-type atpase
WS74_RS06915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WS74_RS06920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WS74_RS06935	COG0028	Belongs to the TPP enzyme family
WS74_RS06945	COG4221	oxidoreductase activity
WS74_RS06950	COG0346	lactoylglutathione lyase activity
WS74_RS06955	COG0656	L-ascorbic acid biosynthetic process
WS74_RS06960	COG1733	regulation of RNA biosynthetic process
WS74_RS06965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WS74_RS06985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WS74_RS06990	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WS74_RS06995	COG1113	amino acid transport
WS74_RS07000	COG0569	domain protein
WS74_RS07010	COG0706	membrane insertase activity
WS74_RS07015	COG0594	ribonuclease P activity
WS74_RS07035	COG1266	CAAX protease self-immunity
WS74_RS07080	COG2369	cell adhesion