locus-tag	class	description
C6N67_RS00075	COG0629	single-stranded DNA binding
C6N67_RS00130	COG1783	phage Terminase large subunit
C6N67_RS00240	COG0588	phosphoglycerate mutase activity
C6N67_RS00245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C6N67_RS00250	COG0336	Belongs to the RNA methyltransferase TrmD family
C6N67_RS00255	COG0335	large ribosomal subunit rRNA binding
C6N67_RS00265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C6N67_RS00270	COG1942	4-Oxalocrotonate Tautomerase
C6N67_RS00275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C6N67_RS00285	COG1428	Deoxynucleoside kinase
C6N67_RS00290	COG1970	mechanosensitive ion channel activity
C6N67_RS00295	COG0561	phosphatase activity
C6N67_RS00360	COG3853	Toxic anion resistance protein (TelA)
C6N67_RS00365	COG1393	Belongs to the ArsC family
C6N67_RS00370	COG4862	establishment of competence for transformation
C6N67_RS00375	COG2723	6-phospho-beta-galactosidase activity
C6N67_RS00380	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C6N67_RS00385	COG1447	Phosphotransferase system cellobiose-specific component IIA
C6N67_RS00390	COG2723	6-phospho-beta-galactosidase activity
C6N67_RS00395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C6N67_RS00405	COG1164	Oligoendopeptidase f
C6N67_RS00410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C6N67_RS00425	COG1609	Transcriptional regulator
C6N67_RS00430	COG0006	proline dipeptidase activity
C6N67_RS00505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C6N67_RS00510	COG3425	synthase
C6N67_RS00525	COG0860	N-Acetylmuramoyl-L-alanine amidase
C6N67_RS00530	COG0124	histidyl-tRNA synthetase
C6N67_RS00535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C6N67_RS00545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C6N67_RS00550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C6N67_RS00555	COG1610	YqeY-like protein
C6N67_RS00560	COG1702	phosphate starvation-inducible protein PhoH
C6N67_RS00565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C6N67_RS00570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C6N67_RS00575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C6N67_RS00580	COG1381	Involved in DNA repair and RecF pathway recombination
C6N67_RS00590	COG0752	glycyl-tRNA synthetase alpha subunit
C6N67_RS00595	COG0751	glycine-tRNA ligase activity
C6N67_RS00615	COG2706	6-phosphogluconolactonase activity
C6N67_RS00620	COG0628	permease
C6N67_RS00630	COG1674	ftsk spoiiie
C6N67_RS00640	COG4152	abc transporter atp-binding protein
C6N67_RS00645	COG1668	transmembrane transport
C6N67_RS00655	COG0322	excinuclease ABC activity
C6N67_RS00660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C6N67_RS00665	COG1739	Uncharacterized protein family UPF0029
C6N67_RS00680	COG0517	IMP dehydrogenase activity
C6N67_RS00680	COG0516	GMP reductase activity
C6N67_RS00685	COG0516	GMP reductase activity
C6N67_RS00685	COG0517	IMP dehydrogenase activity
C6N67_RS00690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C6N67_RS00695	COG0632	four-way junction helicase activity
C6N67_RS00700	COG2255	four-way junction helicase activity
C6N67_RS00740	COG0343	queuine tRNA-ribosyltransferase activity
C6N67_RS00745	COG1862	Preprotein translocase
C6N67_RS00750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6N67_RS00755	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C6N67_RS00760	COG0513	Belongs to the DEAD box helicase family
C6N67_RS00775	COG1929	Belongs to the glycerate kinase type-1 family
C6N67_RS00780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C6N67_RS00800	COG3906	Belongs to the UPF0473 family
C6N67_RS00810	COG2333	competence protein COMEC
C6N67_RS00810	COG0658	competence protein
C6N67_RS00815	COG1466	dna polymerase III delta subunit
C6N67_RS00820	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C6N67_RS00825	COG0268	Binds directly to 16S ribosomal RNA
C6N67_RS00850	COG0544	peptidyl-prolyl cis-trans isomerase activity
C6N67_RS00855	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C6N67_RS00860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C6N67_RS00880	COG1193	negative regulation of DNA recombination
C6N67_RS00900	COG3118	belongs to the thioredoxin family
C6N67_RS00905	COG0187	DNA topoisomerase II activity
C6N67_RS00910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6N67_RS00915	COG3527	Alpha-acetolactate decarboxylase
C6N67_RS00925	COG1473	amidohydrolase
C6N67_RS00940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6N67_RS00960	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C6N67_RS00965	COG3201	nicotinamide mononucleotide transporter
C6N67_RS01005	COG0028	Belongs to the TPP enzyme family
C6N67_RS01020	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C6N67_RS01025	COG0248	Ppx GppA phosphatase
C6N67_RS01035	COG2801	Transposase and inactivated derivatives
C6N67_RS01070	COG0277	FAD linked oxidase domain protein
C6N67_RS01075	COG0436	Aminotransferase
C6N67_RS01090	COG1464	Belongs to the NlpA lipoprotein family
C6N67_RS01100	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C6N67_RS01105	COG0351	phosphomethylpyrimidine kinase
C6N67_RS01110	COG0352	thiamine-phosphate diphosphorylase activity
C6N67_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
C6N67_RS01140	COG1940	carbohydrate kinase activity
C6N67_RS01220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C6N67_RS01225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C6N67_RS01255	COG2801	Transposase and inactivated derivatives
C6N67_RS01260	COG5290	Psort location Cytoplasmic, score
C6N67_RS01270	COG2357	RelA SpoT domain protein
C6N67_RS01275	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C6N67_RS01280	COG0564	pseudouridine synthase activity
C6N67_RS01285	COG2239	Acts as a magnesium transporter
C6N67_RS01290	COG2814	Major facilitator Superfamily
C6N67_RS01305	COG0488	(ABC) transporter
C6N67_RS01350	COG0656	L-ascorbic acid biosynthetic process
C6N67_RS01355	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6N67_RS01365	COG1846	Transcriptional regulator
C6N67_RS01370	COG0456	acetyltransferase
C6N67_RS01435	COG4684	Psort location CytoplasmicMembrane, score
C6N67_RS01445	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C6N67_RS01455	COG0596	Alpha beta hydrolase
C6N67_RS01485	COG0384	phenazine biosynthesis protein PhzF
C6N67_RS01495	COG1621	beta-fructofuranosidase activity
C6N67_RS01515	COG2409	Drug exporters of the RND superfamily
C6N67_RS01515	COG1033	growth of symbiont in host cell
C6N67_RS01530	COG0583	DNA-binding transcription factor activity
C6N67_RS01550	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6N67_RS01555	COG0287	Prephenate dehydrogenase
C6N67_RS01565	COG0738	Major facilitator superfamily
C6N67_RS01570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C6N67_RS01590	COG1304	FMN binding
C6N67_RS01605	COG0779	Required for maturation of 30S ribosomal subunits
C6N67_RS01610	COG0195	Participates in both transcription termination and antitermination
C6N67_RS01615	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C6N67_RS01625	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C6N67_RS01630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C6N67_RS01635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C6N67_RS01640	COG1252	NADH dehydrogenase
C6N67_RS01650	COG0196	riboflavin kinase activity
C6N67_RS01655	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C6N67_RS01660	COG3142	Participates in the control of copper homeostasis
C6N67_RS01675	COG2270	Major facilitator Superfamily
C6N67_RS01680	COG1307	EDD domain protein, DegV family
C6N67_RS01685	COG1307	EDD domain protein, DegV family
C6N67_RS01690	COG2755	lipolytic protein G-D-S-L family
C6N67_RS01700	COG4479	Belongs to the UPF0346 family
C6N67_RS01710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C6N67_RS01715	COG0758	DNA mediated transformation
C6N67_RS01720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6N67_RS01725	COG4974	Belongs to the 'phage' integrase family
C6N67_RS01735	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C6N67_RS01755	COG4175	Glycine betaine
C6N67_RS01755	COG3448	diguanylate cyclase activity
C6N67_RS01770	COG1464	Belongs to the NlpA lipoprotein family
C6N67_RS01775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6N67_RS01780	COG1597	lipid kinase activity
C6N67_RS01785	COG1011	Hydrolase
C6N67_RS01805	COG5503	Protein of unknown function (DUF1447)
C6N67_RS01820	COG0242	peptide deformylase activity
C6N67_RS01825	COG4476	Belongs to the UPF0223 family
C6N67_RS01830	COG0483	inositol monophosphate 1-phosphatase activity
C6N67_RS01835	COG1217	gtp-binding protein TYPA
C6N67_RS01840	COG0772	Belongs to the SEDS family
C6N67_RS01845	COG4471	UPF0298 protein
C6N67_RS01850	COG0742	ribosomal rna small subunit methyltransferase
C6N67_RS01855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C6N67_RS01860	COG3480	Lon protease (S16) C-terminal proteolytic domain
C6N67_RS01865	COG0477	Major facilitator Superfamily
C6N67_RS01875	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C6N67_RS01880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C6N67_RS01950	COG2801	Transposase and inactivated derivatives
C6N67_RS01970	COG0358	DNA primase activity
C6N67_RS01975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6N67_RS02005	COG0745	RESPONSE REGULATOR receiver
C6N67_RS02010	COG5002	protein histidine kinase activity
C6N67_RS02015	COG0572	uridine kinase
C6N67_RS02020	COG1363	Peptidase, m42
C6N67_RS02025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6N67_RS02035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6N67_RS02040	COG0670	Belongs to the BI1 family
C6N67_RS02045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6N67_RS02045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6N67_RS02050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6N67_RS02055	COG0237	dephospho-CoA kinase activity
C6N67_RS02065	COG1484	DNA-dependent DNA replication
C6N67_RS02080	COG0745	RESPONSE REGULATOR receiver
C6N67_RS02085	COG5002	protein histidine kinase activity
C6N67_RS02095	COG3942	CHAP domain
C6N67_RS02095	COG1705	Flagellar rod assembly protein muramidase FlgJ
C6N67_RS02105	COG2801	Transposase and inactivated derivatives
C6N67_RS02130	COG0706	membrane insertase activity
C6N67_RS02135	COG1028	Short-chain dehydrogenase reductase Sdr
C6N67_RS02140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C6N67_RS02150	COG1304	FMN binding
C6N67_RS02170	COG1199	ATP-dependent helicase activity
C6N67_RS02170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6N67_RS02180	COG0017	Asparaginyl-tRNA synthetase
C6N67_RS02185	COG3935	DnaD domain protein
C6N67_RS02195	COG3331	DNA recombination
C6N67_RS02200	COG4474	Belongs to the UPF0398 family
C6N67_RS02205	COG3599	regulation of cell shape
C6N67_RS02215	COG0116	Belongs to the methyltransferase superfamily
C6N67_RS02225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6N67_RS02245	COG0556	nucleotide-excision repair
C6N67_RS02255	COG0439	Biotin carboxylase
C6N67_RS02260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C6N67_RS02270	COG3104	oligopeptide transport
C6N67_RS02275	COG0363	glucosamine-6-phosphate deaminase activity
C6N67_RS02285	COG0537	adenosine 5'-monophosphoramidase activity
C6N67_RS02290	COG1131	(ABC) transporter
C6N67_RS02300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C6N67_RS02305	COG1719	4-vinyl reductase, 4VR
C6N67_RS02310	COG1397	ADP-ribosylglycohydrolase
C6N67_RS02340	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6N67_RS02345	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
C6N67_RS02350	COG1349	DNA-binding transcription factor activity
C6N67_RS02360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6N67_RS02360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6N67_RS02360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6N67_RS02370	COG1609	Transcriptional regulator
C6N67_RS02380	COG0306	phosphate transporter
C6N67_RS02415	COG0531	amino acid
C6N67_RS02425	COG0481	GTPase activity
C6N67_RS02455	COG1028	Short-chain dehydrogenase reductase Sdr
C6N67_RS02460	COG4708	membrane
C6N67_RS02470	COG0531	amino acid
C6N67_RS02480	COG0583	DNA-binding transcription factor activity
C6N67_RS02495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6N67_RS02510	COG1136	(ABC) transporter
C6N67_RS02515	COG0577	efflux transmembrane transporter activity
C6N67_RS02525	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6N67_RS02535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C6N67_RS02540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C6N67_RS02570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C6N67_RS02575	COG2384	SAM-dependent methyltransferase
C6N67_RS02580	COG0071	Belongs to the small heat shock protein (HSP20) family
C6N67_RS02585	COG0457	Tetratricopeptide repeat
C6N67_RS02620	COG0419	ATPase involved in DNA repair
C6N67_RS02625	COG0420	3'-5' exonuclease activity
C6N67_RS02635	COG2807	transmembrane transport
C6N67_RS02640	COG4720	Psort location CytoplasmicMembrane, score
C6N67_RS02645	COG0351	phosphomethylpyrimidine kinase
C6N67_RS02655	COG1160	GTP binding
C6N67_RS02660	COG0539	negative regulation of cytoplasmic translation
C6N67_RS02665	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C6N67_RS02675	COG0514	ATP-dependent DNA helicase (RecQ)
C6N67_RS02685	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C6N67_RS02700	COG1187	pseudouridine synthase activity
C6N67_RS02705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C6N67_RS02710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C6N67_RS02725	COG2996	Protein conserved in bacteria
C6N67_RS02735	COG0475	glutathione-regulated potassium exporter activity
C6N67_RS02745	COG1490	D-aminoacyl-tRNA deacylase activity
C6N67_RS02750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6N67_RS02755	COG0587	DNA-directed DNA polymerase activity
C6N67_RS02765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C6N67_RS02770	COG0488	(ABC) transporter
C6N67_RS02775	COG0617	tRNA 3'-terminal CCA addition
C6N67_RS02785	COG2801	Transposase and inactivated derivatives
C6N67_RS02805	COG1136	(ABC) transporter
C6N67_RS02815	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6N67_RS02820	COG0004	ammonium transporteR
C6N67_RS02830	COG5263	repeat protein
C6N67_RS02830	COG0366	Alpha amylase catalytic
C6N67_RS02835	COG1316	TRANSCRIPTIONal
C6N67_RS02840	COG1216	Glycosyl transferase, family 2
C6N67_RS02855	COG1216	Glycosyl transferase, family 2
C6N67_RS02865	COG0438	transferase activity, transferring glycosyl groups
C6N67_RS02870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6N67_RS02875	COG0489	protein tyrosine kinase activity
C6N67_RS02890	COG0233	cytoplasmic translational termination
C6N67_RS02900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C6N67_RS02905	COG0052	Belongs to the universal ribosomal protein uS2 family
C6N67_RS02910	COG2827	Endonuclease containing a URI domain
C6N67_RS02915	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C6N67_RS02920	COG0204	Acyl-transferase
C6N67_RS02925	COG0791	NLP P60 protein
C6N67_RS02925	COG3883	PFAM NLP P60 protein
C6N67_RS02940	COG3763	UPF0154 protein
C6N67_RS02945	COG4224	UPF0291 protein
C6N67_RS02950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C6N67_RS02970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C6N67_RS02970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C6N67_RS02975	COG1234	tRNA 3'-trailer cleavage
C6N67_RS02990	COG0484	heat shock protein binding
C6N67_RS02995	COG0443	Heat shock 70 kDa protein
C6N67_RS03005	COG1420	regulation of RNA biosynthetic process
C6N67_RS03035	COG1216	Glycosyl transferase, family 2
C6N67_RS03045	COG0463	Glycosyl transferase, family 2
C6N67_RS03055	COG1705	Flagellar rod assembly protein muramidase FlgJ
C6N67_RS03070	COG0562	UDP-galactopyranose mutase
C6N67_RS03095	COG0024	Methionine aminopeptidase
C6N67_RS03115	COG1388	LysM domain
C6N67_RS03115	COG1705	Flagellar rod assembly protein muramidase FlgJ
C6N67_RS03150	COG1682	transport, permease protein
C6N67_RS03155	COG1134	teichoic acid transport
C6N67_RS03155	COG1388	LysM domain
C6N67_RS03160	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C6N67_RS03160	COG0463	Glycosyl transferase, family 2
C6N67_RS03165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C6N67_RS03165	COG0463	Glycosyl transferase, family 2
C6N67_RS03170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C6N67_RS03190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6N67_RS03240	COG3883	PFAM NLP P60 protein
C6N67_RS03240	COG0791	NLP P60 protein
C6N67_RS03315	COG0463	Glycosyl transferase, family 2
C6N67_RS03335	COG2199	diguanylate cyclase activity
C6N67_RS03345	COG2801	Transposase and inactivated derivatives
C6N67_RS03380	COG2309	aminopeptidase activity
C6N67_RS03395	COG0564	pseudouridine synthase activity
C6N67_RS03400	COG1278	Cold shock
C6N67_RS03410	COG2814	Major facilitator Superfamily
C6N67_RS03415	COG0741	lytic transglycosylase activity
C6N67_RS03425	COG3973	AAA domain
C6N67_RS03435	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C6N67_RS03440	COG1546	Belongs to the CinA family
C6N67_RS03440	COG1058	Belongs to the CinA family
C6N67_RS03445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6N67_RS03450	COG1426	Protein conserved in bacteria
C6N67_RS03455	COG0612	Peptidase, M16
C6N67_RS03460	COG0612	Peptidase, M16
C6N67_RS03475	COG0028	Belongs to the TPP enzyme family
C6N67_RS03495	COG4717	serine-type aminopeptidase activity
C6N67_RS03515	COG3679	Belongs to the UPF0342 family
C6N67_RS03520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6N67_RS03525	COG1438	arginine binding
C6N67_RS03545	COG0018	arginyl-trna synthetase
C6N67_RS03560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C6N67_RS03570	COG1121	(ABC) transporter
C6N67_RS03585	COG2826	transposase and inactivated derivatives, IS30 family
C6N67_RS03595	COG1597	lipid kinase activity
C6N67_RS03600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6N67_RS03605	COG0154	amidase activity
C6N67_RS03610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6N67_RS03615	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C6N67_RS03615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C6N67_RS03640	COG1695	Transcriptional regulator
C6N67_RS03650	COG1914	H( )-stimulated, divalent metal cation uptake system
C6N67_RS03670	COG0667	Aldo Keto reductase
C6N67_RS03675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6N67_RS03680	COG4721	ABC-type cobalt transport system, permease component
C6N67_RS03685	COG1122	ATPase activity
C6N67_RS03700	COG0710	3-dehydroquinate dehydratase activity
C6N67_RS03705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C6N67_RS03710	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6N67_RS03715	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C6N67_RS03720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C6N67_RS03725	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C6N67_RS03730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6N67_RS03745	COG4684	Psort location CytoplasmicMembrane, score
C6N67_RS03750	COG0436	Aminotransferase
C6N67_RS03765	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C6N67_RS03770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C6N67_RS03775	COG0436	Aminotransferase
C6N67_RS03780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C6N67_RS03785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6N67_RS03795	COG2171	N-acyltransferase activity
C6N67_RS03805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6N67_RS03810	COG0527	aspartate kinase activity
C6N67_RS03820	COG1609	Transcriptional regulator
C6N67_RS03825	COG0083	homoserine kinase activity
C6N67_RS03840	COG1321	iron dependent repressor
C6N67_RS03845	COG3764	Sortase (surface protein transpeptidase)
C6N67_RS03865	COG0513	Belongs to the DEAD box helicase family
C6N67_RS03870	COG0673	inositol 2-dehydrogenase activity
C6N67_RS03875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6N67_RS03885	COG0501	Belongs to the peptidase M48B family
C6N67_RS03890	COG1704	LemA family
C6N67_RS03900	COG4115	mRNA cleavage
C6N67_RS03905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6N67_RS03920	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C6N67_RS03930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C6N67_RS03935	COG0439	Biotin carboxylase
C6N67_RS03950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6N67_RS03955	COG1028	Short-chain dehydrogenase reductase Sdr
C6N67_RS03960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C6N67_RS03965	COG2070	2-Nitropropane dioxygenase
C6N67_RS03970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6N67_RS03975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C6N67_RS03980	COG1846	Transcriptional regulator
C6N67_RS03985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C6N67_RS03995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C6N67_RS04000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6N67_RS04010	COG0505	Belongs to the CarA family
C6N67_RS04020	COG0564	pseudouridine synthase activity
C6N67_RS04030	COG0328	RNA-DNA hybrid ribonuclease activity
C6N67_RS04035	COG1757	Na H antiporter
C6N67_RS04040	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C6N67_RS04045	COG1113	amino acid transport
C6N67_RS04195	COG2801	Transposase and inactivated derivatives
C6N67_RS04210	COG1396	sequence-specific DNA binding
C6N67_RS04230	COG4974	Belongs to the 'phage' integrase family
C6N67_RS04255	COG1454	alcohol dehydrogenase
C6N67_RS04255	COG1012	belongs to the aldehyde dehydrogenase family
C6N67_RS04260	COG0105	UTP biosynthetic process
C6N67_RS04270	COG0583	DNA-binding transcription factor activity
C6N67_RS04275	COG0126	phosphoglycerate kinase activity
C6N67_RS04325	COG0588	phosphoglycerate mutase activity
C6N67_RS04335	COG3716	PTS system mannose fructose sorbose family IID component
C6N67_RS04340	COG3715	PTS system
C6N67_RS04355	COG1397	ADP-ribosylglycohydrolase
C6N67_RS04415	COG1368	sulfuric ester hydrolase activity
C6N67_RS04430	COG0438	transferase activity, transferring glycosyl groups
C6N67_RS04435	COG0438	transferase activity, transferring glycosyl groups
C6N67_RS04440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C6N67_RS04445	COG0284	orotidine-5'-phosphate decarboxylase activity
C6N67_RS04450	COG0167	dihydroorotate dehydrogenase activity
C6N67_RS04455	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C6N67_RS04465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C6N67_RS04470	COG0540	Belongs to the ATCase OTCase family
C6N67_RS04490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6N67_RS04495	COG4856	YbbR-like protein
C6N67_RS04510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C6N67_RS04525	COG0802	atpase or kinase
C6N67_RS04530	COG0280	phosphate acetyltransferase
C6N67_RS04545	COG2076	Multidrug Resistance protein
C6N67_RS04550	COG2076	Multidrug Resistance protein
C6N67_RS04555	COG1126	abc transporter atp-binding protein
C6N67_RS04560	COG0765	amino acid transport
C6N67_RS04580	COG0557	exoribonuclease II activity
C6N67_RS04590	COG2814	Major facilitator Superfamily
C6N67_RS04595	COG0154	amidase activity
C6N67_RS04615	COG0149	triose-phosphate isomerase activity
C6N67_RS04620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6N67_RS04625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6N67_RS04635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C6N67_RS04640	COG0492	ferredoxin-NADP+ reductase activity
C6N67_RS04665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C6N67_RS04670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C6N67_RS04675	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C6N67_RS04680	COG1950	PFAM Membrane protein of
C6N67_RS04690	COG0589	response to stress
C6N67_RS04700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C6N67_RS04710	COG1177	transmembrane transport
C6N67_RS04720	COG3842	ATPase activity
C6N67_RS04730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C6N67_RS04735	COG0049	tRNA binding
C6N67_RS04740	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C6N67_RS04755	COG4608	Belongs to the ABC transporter superfamily
C6N67_RS04760	COG0444	Belongs to the ABC transporter superfamily
C6N67_RS04765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6N67_RS04770	COG0601	transmembrane transport
C6N67_RS04780	COG0460	homoserine dehydrogenase
C6N67_RS04785	COG0626	cystathionine gamma-synthase activity
C6N67_RS04790	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C6N67_RS04800	COG1744	ABC transporter substrate-binding protein PnrA-like
C6N67_RS04805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C6N67_RS04810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C6N67_RS04825	COG1302	Protein conserved in bacteria
C6N67_RS04830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C6N67_RS04840	COG2017	converts alpha-aldose to the beta-anomer
C6N67_RS04850	COG4975	Glucose uptake
C6N67_RS04855	COG3850	Histidine kinase
C6N67_RS04855	COG5002	protein histidine kinase activity
C6N67_RS04860	COG0745	RESPONSE REGULATOR receiver
C6N67_RS04865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6N67_RS04870	COG0402	S-adenosylhomocysteine deaminase activity
C6N67_RS04875	COG0673	inositol 2-dehydrogenase activity
C6N67_RS04900	COG0668	transmembrane transport
C6N67_RS04910	COG1126	abc transporter atp-binding protein
C6N67_RS04945	COG0516	GMP reductase activity
C6N67_RS05010	COG0494	nUDIX hydrolase
C6N67_RS05045	COG0738	Major facilitator superfamily
C6N67_RS05050	COG1869	D-ribose catabolic process
C6N67_RS05055	COG1609	Transcriptional regulator
C6N67_RS05075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6N67_RS05090	COG1609	Transcriptional regulator
C6N67_RS05110	COG2223	nitrite transmembrane transporter activity
C6N67_RS05130	COG1116	anion transmembrane transporter activity
C6N67_RS05135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6N67_RS05145	COG0285	dihydrofolate synthase activity
C6N67_RS05150	COG0302	gtp cyclohydrolase
C6N67_RS05155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C6N67_RS05155	COG0302	gtp cyclohydrolase
C6N67_RS05170	COG0561	phosphatase activity
C6N67_RS05190	COG1464	Belongs to the NlpA lipoprotein family
C6N67_RS05195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6N67_RS05200	COG0800	Aldolase
C6N67_RS05205	COG1904	glucuronate isomerase
C6N67_RS05210	COG1312	Catalyzes the dehydration of D-mannonate
C6N67_RS05215	COG0246	Mannitol dehydrogenase
C6N67_RS05230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6N67_RS05245	COG1609	Transcriptional regulator
C6N67_RS05275	COG0577	efflux transmembrane transporter activity
C6N67_RS05280	COG1136	(ABC) transporter
C6N67_RS05285	COG3759	membrane
C6N67_RS05305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6N67_RS05310	COG2235	arginine
C6N67_RS05320	COG2217	Heavy metal translocating P-type atpase
C6N67_RS05375	COG0438	transferase activity, transferring glycosyl groups
C6N67_RS05430	COG2814	Major facilitator Superfamily
C6N67_RS05435	COG2217	Heavy metal translocating P-type atpase
C6N67_RS05475	COG3711	transcriptional antiterminator
C6N67_RS05480	COG2723	6-phospho-beta-galactosidase activity
C6N67_RS05485	COG1940	carbohydrate kinase activity
C6N67_RS05510	COG2183	response to ionizing radiation
C6N67_RS05520	COG2873	o-acetylhomoserine
C6N67_RS05525	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C6N67_RS05530	COG1040	competence protein
C6N67_RS05535	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C6N67_RS05615	COG2176	DNA-directed DNA polymerase activity
C6N67_RS05620	COG0442	prolyl-tRNA aminoacylation
C6N67_RS05625	COG0750	zinc metalloprotease
C6N67_RS05630	COG4589	Belongs to the CDS family
C6N67_RS05635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6N67_RS05640	COG0561	phosphatase activity
C6N67_RS05645	COG2246	polysaccharide biosynthetic process
C6N67_RS05670	COG1811	Na channel or pump
C6N67_RS05675	COG1979	alcohol dehydrogenase
C6N67_RS05705	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C6N67_RS05715	COG0307	riboflavin synthase, alpha
C6N67_RS05720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6N67_RS05720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6N67_RS05725	COG2076	Multidrug Resistance protein
C6N67_RS05730	COG2076	Multidrug Resistance protein
C6N67_RS05735	COG1435	thymidine kinase activity
C6N67_RS05755	COG0656	L-ascorbic acid biosynthetic process
C6N67_RS05760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6N67_RS05785	COG4166	transmembrane transport
C6N67_RS05830	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C6N67_RS05835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C6N67_RS05845	COG2252	PERMEase
C6N67_RS05855	COG0352	thiamine-phosphate diphosphorylase activity
C6N67_RS05860	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C6N67_RS05875	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C6N67_RS05885	COG2188	Transcriptional regulator
C6N67_RS05895	COG1136	(ABC) transporter
C6N67_RS05895	COG0577	efflux transmembrane transporter activity
C6N67_RS05905	COG0561	phosphatase activity
C6N67_RS05910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6N67_RS05910	COG2169	Transcriptional regulator
C6N67_RS05915	COG0561	phosphatase activity
C6N67_RS05935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C6N67_RS05940	COG0772	Belongs to the SEDS family
C6N67_RS05950	COG1077	Cell shape determining protein MreB Mrl
C6N67_RS05955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C6N67_RS05960	COG1079	Belongs to the binding-protein-dependent transport system permease family
C6N67_RS05965	COG4603	Belongs to the binding-protein-dependent transport system permease family
C6N67_RS05970	COG3845	ABC transporter
C6N67_RS05975	COG1744	ABC transporter substrate-binding protein PnrA-like
C6N67_RS05980	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6N67_RS05990	COG0640	Transcriptional regulator
C6N67_RS05995	COG0628	permease
C6N67_RS06000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C6N67_RS06020	COG0386	Belongs to the glutathione peroxidase family
C6N67_RS06025	COG2357	RelA SpoT domain protein
C6N67_RS06030	COG0588	phosphoglycerate mutase activity
C6N67_RS06040	COG0492	ferredoxin-NADP+ reductase activity
C6N67_RS06055	COG1744	ABC transporter substrate-binding protein PnrA-like
C6N67_RS06060	COG1744	ABC transporter substrate-binding protein PnrA-like
C6N67_RS06070	COG2832	Protein of unknown function (DUF454)
C6N67_RS06095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6N67_RS06105	COG2814	Major facilitator Superfamily
C6N67_RS06110	COG0305	Participates in initiation and elongation during chromosome replication
C6N67_RS06115	COG0359	binds to the 23S rRNA
C6N67_RS06125	COG4608	Belongs to the ABC transporter superfamily
C6N67_RS06130	COG0444	Belongs to the ABC transporter superfamily
C6N67_RS06135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6N67_RS06140	COG0601	transmembrane transport
C6N67_RS06145	COG4166	transmembrane transport
C6N67_RS06150	COG0765	amino acid transport
C6N67_RS06155	COG0765	amino acid transport
C6N67_RS06160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6N67_RS06180	COG0194	GDP metabolic process
C6N67_RS06185	COG1268	BioY protein
C6N67_RS06215	COG2211	Major facilitator Superfamily
C6N67_RS06220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C6N67_RS06235	COG3973	AAA domain
C6N67_RS06260	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C6N67_RS06270	COG1696	Membrane protein involved in D-alanine export
C6N67_RS06290	COG2337	Toxic component of a toxin-antitoxin (TA) module
C6N67_RS06305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C6N67_RS06310	COG0504	CTP synthase activity
C6N67_RS06320	COG3343	RNA polymerase activity
C6N67_RS06325	COG0561	phosphatase activity
C6N67_RS06330	COG1078	dGTPase activity
C6N67_RS06340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6N67_RS06345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C6N67_RS06365	COG0745	RESPONSE REGULATOR receiver
C6N67_RS06390	COG2826	transposase and inactivated derivatives, IS30 family
C6N67_RS06400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C6N67_RS06405	COG0629	single-stranded DNA binding
C6N67_RS06410	COG0360	Binds together with S18 to 16S ribosomal RNA
C6N67_RS06420	COG1957	nucleoside hydrolase
C6N67_RS06425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6N67_RS06435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6N67_RS06440	COG1051	belongs to the nudix hydrolase family
C6N67_RS06455	COG2814	Major facilitator Superfamily
C6N67_RS06460	COG1064	alcohol dehydrogenase
C6N67_RS06465	COG1074	ATP-dependent DNA helicase activity
C6N67_RS06470	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C6N67_RS06485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6N67_RS06490	COG2197	response regulator
C6N67_RS06495	COG4585	Histidine kinase
C6N67_RS06505	COG2409	Drug exporters of the RND superfamily
C6N67_RS06510	COG2801	Transposase and inactivated derivatives
C6N67_RS06520	COG2409	Drug exporters of the RND superfamily
C6N67_RS06525	COG0531	amino acid
C6N67_RS06530	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C6N67_RS06540	COG1902	pentaerythritol trinitrate reductase activity
C6N67_RS06545	COG0626	cystathionine gamma-synthase activity
C6N67_RS06560	COG2244	polysaccharide biosynthetic process
C6N67_RS06570	COG0438	transferase activity, transferring glycosyl groups
C6N67_RS06575	COG0495	leucyl-tRNA aminoacylation
C6N67_RS06580	COG0671	phosphoesterase, PA-phosphatase related
C6N67_RS06590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6N67_RS06615	COG2723	6-phospho-beta-galactosidase activity
C6N67_RS06640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C6N67_RS06655	COG0024	Methionine aminopeptidase
C6N67_RS06665	COG1316	TRANSCRIPTIONal
C6N67_RS06675	COG2205	protein histidine kinase activity
C6N67_RS06680	COG0745	RESPONSE REGULATOR receiver
C6N67_RS06685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6N67_RS06700	COG2207	Transcriptional regulator
C6N67_RS06720	COG0308	aminopeptidase N
C6N67_RS06725	COG0833	amino acid
C6N67_RS06730	COG2040	homocysteine
C6N67_RS06735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6N67_RS06740	COG0542	response to heat
C6N67_RS06755	COG0395	ABC-type sugar transport system, permease component
C6N67_RS06760	COG1175	transmembrane transport
C6N67_RS06810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6N67_RS06820	COG0107	imidazoleglycerol-phosphate synthase activity
C6N67_RS06825	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C6N67_RS06835	COG0131	Imidazoleglycerol-phosphate dehydratase
C6N67_RS06840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C6N67_RS06850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C6N67_RS06970	COG0438	transferase activity, transferring glycosyl groups
C6N67_RS06995	COG2084	Dehydrogenase
C6N67_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
C6N67_RS07010	COG1620	l-lactate permease
C6N67_RS07015	COG4989	oxidoreductase activity
C6N67_RS07020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6N67_RS07025	COG2233	PERMEase
C6N67_RS07040	COG1956	GAF domain-containing protein
C6N67_RS07065	COG0747	negative chemotaxis
C6N67_RS07070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6N67_RS07075	COG0601	transmembrane transport
C6N67_RS07080	COG4608	Belongs to the ABC transporter superfamily
C6N67_RS07085	COG0444	Belongs to the ABC transporter superfamily
C6N67_RS07095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C6N67_RS07100	COG2211	Major facilitator Superfamily
C6N67_RS07100	COG2190	(PTS) system
C6N67_RS07120	COG0436	Aminotransferase
C6N67_RS07130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C6N67_RS07135	COG2801	Transposase and inactivated derivatives
C6N67_RS07145	COG2723	6-phospho-beta-galactosidase activity
C6N67_RS07150	COG2723	6-phospho-beta-galactosidase activity
C6N67_RS07155	COG1447	Phosphotransferase system cellobiose-specific component IIA
C6N67_RS07160	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C6N67_RS07165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6N67_RS07170	COG1216	Glycosyl transferase, family 2
C6N67_RS07185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C6N67_RS07245	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C6N67_RS07250	COG1737	Transcriptional regulator
C6N67_RS07260	COG0656	L-ascorbic acid biosynthetic process
C6N67_RS07265	COG2261	transglycosylase associated protein
C6N67_RS07330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6N67_RS07350	COG0037	tRNA processing
C6N67_RS07360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C6N67_RS07365	COG2244	polysaccharide biosynthetic process
C6N67_RS07370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C6N67_RS07375	COG0193	aminoacyl-tRNA hydrolase activity
C6N67_RS07385	COG0058	SHG alpha-glucan phosphorylase activity
C6N67_RS07390	COG0297	glycogen (starch) synthase activity
C6N67_RS07395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C6N67_RS07405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C6N67_RS07410	COG1511	domain protein
C6N67_RS07410	COG1511	domain protein
C6N67_RS07415	COG1309	transcriptional regulator
C6N67_RS07430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C6N67_RS07435	COG0477	Major facilitator Superfamily
C6N67_RS07450	COG0667	Aldo Keto reductase
C6N67_RS07460	COG2115	Belongs to the xylose isomerase family
C6N67_RS07470	COG2211	Major facilitator Superfamily
C6N67_RS07475	COG3507	Belongs to the glycosyl hydrolase 43 family
C6N67_RS07500	COG2818	Glycosylase
C6N67_RS07505	COG1968	undecaprenyl-diphosphatase activity
C6N67_RS07520	COG1695	Transcriptional regulator
C6N67_RS07525	COG1983	PspC domain protein
C6N67_RS07530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C6N67_RS07535	COG0737	Belongs to the 5'-nucleotidase family
C6N67_RS07550	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C6N67_RS07560	COG2723	6-phospho-beta-galactosidase activity
C6N67_RS07570	COG1316	TRANSCRIPTIONal
C6N67_RS07580	COG2131	deaminase
C6N67_RS07585	COG4466	Protein conserved in bacteria
C6N67_RS07590	COG1253	flavin adenine dinucleotide binding
C6N67_RS07595	COG1253	flavin adenine dinucleotide binding
C6N67_RS07600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6N67_RS07605	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C6N67_RS07610	COG0084	hydrolase, TatD family'
C6N67_RS07620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6N67_RS07620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6N67_RS07640	COG2826	transposase and inactivated derivatives, IS30 family
C6N67_RS07685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C6N67_RS07705	COG1368	sulfuric ester hydrolase activity
C6N67_RS07710	COG2153	protein acetylation
C6N67_RS07725	COG0187	DNA topoisomerase II activity
C6N67_RS07730	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6N67_RS07735	COG2501	S4 domain
C6N67_RS07740	COG0592	DNA-directed DNA polymerase activity
C6N67_RS07745	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6N67_RS07750	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C6N67_RS07755	COG0594	ribonuclease P activity
C6N67_RS07760	COG0706	membrane insertase activity
C6N67_RS07770	COG1120	ATPase activity
C6N67_RS07780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C6N67_RS07795	COG0569	domain protein
C6N67_RS07800	COG1113	amino acid transport
C6N67_RS07820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6N67_RS07830	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6N67_RS07840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C6N67_RS07845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C6N67_RS07855	COG1136	(ABC) transporter
C6N67_RS07860	COG0577	efflux transmembrane transporter activity
C6N67_RS07865	COG1033	growth of symbiont in host cell
C6N67_RS07865	COG2409	Drug exporters of the RND superfamily
C6N67_RS07870	COG0561	phosphatase activity
C6N67_RS07880	COG0328	RNA-DNA hybrid ribonuclease activity
C6N67_RS07900	COG3152	Membrane
C6N67_RS07905	COG2252	PERMEase
C6N67_RS07945	COG1881	PFAM PEBP family protein
C6N67_RS07965	COG1476	TRANSCRIPTIONal
C6N67_RS08020	COG0697	spore germination
C6N67_RS08035	COG1874	Beta-galactosidase
C6N67_RS08050	COG0561	phosphatase activity
C6N67_RS08060	COG1744	ABC transporter substrate-binding protein PnrA-like
C6N67_RS08065	COG0137	argininosuccinate synthase activity
C6N67_RS08070	COG0165	Argininosuccinate lyase
C6N67_RS08075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C6N67_RS08080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C6N67_RS08095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6N67_RS08100	COG0505	Belongs to the CarA family
C6N67_RS08105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C6N67_RS08125	COG1131	(ABC) transporter
C6N67_RS08150	COG0789	Transcriptional regulator
C6N67_RS08155	COG1028	Short-chain dehydrogenase reductase Sdr
C6N67_RS08165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6N67_RS08175	COG0697	spore germination
C6N67_RS08180	COG1744	ABC transporter substrate-binding protein PnrA-like
C6N67_RS08200	COG1846	Transcriptional regulator
C6N67_RS08215	COG0656	L-ascorbic acid biosynthetic process
C6N67_RS08225	COG4619	ABC transporter
C6N67_RS08230	COG0390	transport system, permease component
C6N67_RS08240	COG1131	(ABC) transporter
C6N67_RS08250	COG1126	abc transporter atp-binding protein
C6N67_RS08255	COG0765	amino acid transport
C6N67_RS08260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6N67_RS08265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6N67_RS08270	COG1254	Belongs to the acylphosphatase family
C6N67_RS08280	COG0392	lysyltransferase activity
C6N67_RS08280	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C6N67_RS08290	COG0628	permease
C6N67_RS08320	COG1113	amino acid transport
C6N67_RS08345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6N67_RS08350	COG0454	-acetyltransferase
C6N67_RS08350	COG0456	acetyltransferase
C6N67_RS08360	COG2855	membrane
C6N67_RS08365	COG3620	sequence-specific DNA binding
C6N67_RS08375	COG2855	membrane
C6N67_RS08380	COG0583	DNA-binding transcription factor activity
C6N67_RS08390	COG2070	2-Nitropropane dioxygenase
C6N67_RS08405	COG1228	amidohydrolase
C6N67_RS08410	COG0531	amino acid
C6N67_RS08420	COG3223	Belongs to the PsiE family
C6N67_RS08430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6N67_RS08440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C6N67_RS08450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C6N67_RS08455	COG4166	transmembrane transport
C6N67_RS08460	COG2267	carboxylic ester hydrolase activity
C6N67_RS08465	COG1131	(ABC) transporter
C6N67_RS08485	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C6N67_RS08495	COG0477	Major facilitator Superfamily
C6N67_RS08500	COG4975	Glucose uptake
C6N67_RS08515	COG0531	amino acid
C6N67_RS08520	COG1113	amino acid transport
C6N67_RS08525	COG0531	amino acid
C6N67_RS08530	COG0252	asparaginase activity
C6N67_RS08535	COG4443	Transcriptional Coactivator p15 (PC4)
C6N67_RS08545	COG2226	methyltransferase
C6N67_RS08550	COG1335	isochorismatase
C6N67_RS08555	COG2050	protein possibly involved in aromatic compounds catabolism
C6N67_RS08560	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C6N67_RS08565	COG0318	PFAM AMP-dependent synthetase and ligase
C6N67_RS08580	COG0745	RESPONSE REGULATOR receiver
C6N67_RS08585	COG5002	protein histidine kinase activity
C6N67_RS08625	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C6N67_RS08630	COG1194	a g-specific adenine glycosylase
C6N67_RS08640	COG0357	Ribosomal RNA small subunit methyltransferase G
C6N67_RS08645	COG1192	Involved in chromosome partitioning
C6N67_RS08650	COG1475	DNA binding
C6N67_RS08655	COG4481	Protein conserved in bacteria
C6N67_RS08660	COG0012	GTP binding
C6N67_RS08670	COG0745	RESPONSE REGULATOR receiver
C6N67_RS08680	COG1686	Belongs to the peptidase S11 family
C6N67_RS08730	COG3104	oligopeptide transport
C6N67_RS08735	COG0477	Major facilitator Superfamily
C6N67_RS08740	COG4975	Glucose uptake
C6N67_RS08790	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C6N67_RS08790	COG2755	lipolytic protein G-D-S-L family
C6N67_RS08795	COG1846	Transcriptional regulator
C6N67_RS08805	COG1121	(ABC) transporter
C6N67_RS08810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6N67_RS08815	COG1373	ATPase (AAA superfamily
C6N67_RS08820	COG0488	(ABC) transporter
C6N67_RS08825	COG0534	Mate efflux family protein
C6N67_RS08840	COG3940	Belongs to the glycosyl hydrolase 43 family
C6N67_RS08860	COG2160	L-arabinose isomerase activity
C6N67_RS08865	COG0656	L-ascorbic acid biosynthetic process
C6N67_RS08895	COG0765	amino acid transport
C6N67_RS08930	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C6N67_RS08935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C6N67_RS08950	COG1418	mRNA catabolic process
C6N67_RS08955	COG2814	Major facilitator Superfamily
C6N67_RS08965	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6N67_RS08970	COG2188	Transcriptional regulator
C6N67_RS08975	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C6N67_RS08990	COG5039	Polysaccharide pyruvyl transferase
C6N67_RS09000	COG2801	Transposase and inactivated derivatives
C6N67_RS09055	COG3590	peptidase
C6N67_RS09060	COG1454	alcohol dehydrogenase
C6N67_RS09060	COG1012	belongs to the aldehyde dehydrogenase family
C6N67_RS09070	COG0708	Exodeoxyribonuclease III
C6N67_RS09090	COG0588	phosphoglycerate mutase activity
C6N67_RS09095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C6N67_RS09110	COG1132	(ABC) transporter
C6N67_RS09115	COG1132	(ABC) transporter
C6N67_RS09120	COG1373	ATPase (AAA superfamily
C6N67_RS09145	COG0110	maltose O-acetyltransferase activity
C6N67_RS09155	COG1482	cell wall glycoprotein biosynthetic process
C6N67_RS09160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C6N67_RS09165	COG3442	glutamine amidotransferase
C6N67_RS09175	COG1435	thymidine kinase activity
C6N67_RS09180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C6N67_RS09185	COG2890	protein-(glutamine-N5) methyltransferase activity
C6N67_RS09195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6N67_RS09200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C6N67_RS09205	COG0702	epimerase
C6N67_RS09215	COG2233	PERMEase
C6N67_RS09220	COG0356	it plays a direct role in the translocation of protons across the membrane
C6N67_RS09225	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6N67_RS09230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C6N67_RS09235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6N67_RS09240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C6N67_RS09245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C6N67_RS09250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C6N67_RS09255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C6N67_RS09260	COG1876	peptidase activity
C6N67_RS09265	COG1428	Deoxynucleoside kinase
C6N67_RS09270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C6N67_RS09295	COG4463	regulation of RNA biosynthetic process
C6N67_RS09300	COG0542	response to heat
C6N67_RS09305	COG0085	RNA polymerase activity
C6N67_RS09325	COG1979	alcohol dehydrogenase
C6N67_RS09360	COG1309	transcriptional regulator
C6N67_RS09365	COG0500	methyltransferase
C6N67_RS09410	COG3620	sequence-specific DNA binding
C6N67_RS09420	COG2807	transmembrane transport
C6N67_RS09430	COG2813	Specifically methylates the guanine in position
C6N67_RS09435	COG0590	tRNA wobble adenosine to inosine editing
C6N67_RS09445	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C6N67_RS09470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6N67_RS09475	COG3870	Protein conserved in bacteria
C6N67_RS09495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C6N67_RS09500	COG1214	PFAM Peptidase M22, glycoprotease
C6N67_RS09505	COG0456	acetyltransferase
C6N67_RS09515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C6N67_RS09520	COG0142	geranyltranstransferase activity
C6N67_RS09525	COG0051	transcription antitermination factor activity, RNA binding
C6N67_RS09530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C6N67_RS09540	COG0089	rRNA binding
C6N67_RS09545	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C6N67_RS09550	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C6N67_RS09555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C6N67_RS09560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C6N67_RS09565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C6N67_RS09570	COG0255	Belongs to the universal ribosomal protein uL29 family
C6N67_RS09580	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C6N67_RS09585	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C6N67_RS09590	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C6N67_RS09595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C6N67_RS09600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C6N67_RS09605	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C6N67_RS09610	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C6N67_RS09615	COG1841	ribosomal large subunit assembly
C6N67_RS09620	COG0200	Binds to the 23S rRNA
C6N67_RS09635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C6N67_RS09640	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C6N67_RS09645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C6N67_RS09650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C6N67_RS09655	COG0202	RNA polymerase activity
C6N67_RS09660	COG0203	ribosomal protein L17
C6N67_RS09685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C6N67_RS09700	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C6N67_RS09725	COG0583	DNA-binding transcription factor activity
C6N67_RS09730	COG0114	fumarate hydratase activity
C6N67_RS09735	COG1053	succinate dehydrogenase
C6N67_RS09740	COG0471	metal ion transport
C6N67_RS09745	COG0039	L-malate dehydrogenase activity
C6N67_RS09750	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C6N67_RS09755	COG0215	cysteine-tRNA ligase activity
C6N67_RS09765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C6N67_RS09770	COG1464	Belongs to the NlpA lipoprotein family
C6N67_RS09775	COG1854	S-ribosylhomocysteine lyase activity
C6N67_RS09780	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C6N67_RS09785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6N67_RS09800	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6N67_RS09805	COG0250	Participates in transcription elongation, termination and antitermination
C6N67_RS09810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C6N67_RS09815	COG0081	regulation of translation
C6N67_RS09820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C6N67_RS09825	COG0222	ribosome binding
C6N67_RS09835	COG1121	(ABC) transporter
C6N67_RS09840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6N67_RS09850	COG1252	NADH dehydrogenase
C6N67_RS09860	COG1122	ATPase activity
C6N67_RS09865	COG1122	ATPase activity
C6N67_RS09875	COG0101	tRNA pseudouridine synthase activity
C6N67_RS09880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C6N67_RS09895	COG0028	Belongs to the TPP enzyme family
C6N67_RS09905	COG1573	uracil-dna glycosylase
C6N67_RS09920	COG0366	Alpha amylase catalytic
C6N67_RS09930	COG0671	phosphoesterase, PA-phosphatase related
C6N67_RS09935	COG2226	methyltransferase
C6N67_RS09945	COG2814	Major facilitator Superfamily
C6N67_RS09950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6N67_RS09965	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C6N67_RS09970	COG1481	regulation of sporulation
C6N67_RS09975	COG0740	serine-type endopeptidase activity
C6N67_RS09990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6N67_RS09990	COG1263	PTS System
C6N67_RS10000	COG1914	H( )-stimulated, divalent metal cation uptake system
C6N67_RS10020	COG0039	L-malate dehydrogenase activity
C6N67_RS10025	COG0028	Belongs to the TPP enzyme family
C6N67_RS10030	COG3527	Alpha-acetolactate decarboxylase
C6N67_RS10040	COG3942	CHAP domain
C6N67_RS10040	COG1388	LysM domain
C6N67_RS10045	COG0791	NLP P60 protein
C6N67_RS10055	COG0756	dUTP diphosphatase activity
C6N67_RS10065	COG4956	integral membrane protein (PIN domain superfamily)
C6N67_RS10075	COG0653	protein targeting
C6N67_RS10080	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C6N67_RS10100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6N67_RS10110	COG1733	regulation of RNA biosynthetic process
C6N67_RS10115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C6N67_RS10120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6N67_RS10120	COG0072	phenylalanine-tRNA ligase activity
C6N67_RS10125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C6N67_RS10130	COG0514	ATP-dependent DNA helicase (RecQ)
C6N67_RS10135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6N67_RS10145	COG0768	penicillin binding
C6N67_RS10150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C6N67_RS10165	COG1940	carbohydrate kinase activity
C6N67_RS10175	COG3409	Peptidoglycan-binding domain 1 protein
C6N67_RS10175	COG5632	N-Acetylmuramoyl-L-alanine amidase
C6N67_RS10180	COG3942	CHAP domain
C6N67_RS10200	COG0584	glycerophosphoryl diester phosphodiesterase
C6N67_RS10205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C6N67_RS10210	COG0789	Transcriptional regulator
C6N67_RS10215	COG0174	glutamine synthetase
C6N67_RS10245	COG2801	Transposase and inactivated derivatives
C6N67_RS10260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C6N67_RS10265	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C6N67_RS10290	COG0778	Nitroreductase
C6N67_RS10295	COG1169	isochorismate synthase
C6N67_RS10300	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C6N67_RS10305	COG0596	Alpha beta hydrolase
C6N67_RS10310	COG4948	Mandelate Racemase Muconate Lactonizing
C6N67_RS10335	COG0737	Belongs to the 5'-nucleotidase family
C6N67_RS10340	COG4470	Protein conserved in bacteria
C6N67_RS10345	COG0647	UMP catabolic process
C6N67_RS10355	COG4166	transmembrane transport
C6N67_RS10360	COG0673	inositol 2-dehydrogenase activity
C6N67_RS10390	COG0573	inorganic phosphate transmembrane transporter activity
C6N67_RS10395	COG0581	inorganic phosphate transmembrane transporter activity
C6N67_RS10400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6N67_RS10405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6N67_RS10410	COG0704	Plays a role in the regulation of phosphate uptake
C6N67_RS10415	COG2137	regulation of response to DNA damage stimulus
C6N67_RS10455	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C6N67_RS10465	COG5506	Protein of unknown function (DUF1694)
C6N67_RS10475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C6N67_RS10580	COG1272	protein, Hemolysin III
C6N67_RS10615	COG0525	valine-tRNA ligase activity
C6N67_RS10625	COG0285	dihydrofolate synthase activity
C6N67_RS10645	COG0488	(ABC) transporter
C6N67_RS10650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C6N67_RS10655	COG0459	protein refolding
C6N67_RS10660	COG0531	amino acid
C6N67_RS10670	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6N67_RS10675	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C6N67_RS10680	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C6N67_RS10690	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C6N67_RS10695	COG1713	HD superfamily hydrolase involved in NAD metabolism
C6N67_RS10700	COG0799	negative regulation of ribosome biogenesis
C6N67_RS10705	COG2226	methyltransferase
C6N67_RS10710	COG1323	Belongs to the UPF0348 family
C6N67_RS10720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C6N67_RS10725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C6N67_RS10820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C6N67_RS10830	COG0363	glucosamine-6-phosphate deaminase activity
C6N67_RS10835	COG0776	regulation of translation
C6N67_RS10850	COG1136	(ABC) transporter
C6N67_RS10865	COG4720	Psort location CytoplasmicMembrane, score
C6N67_RS10870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C6N67_RS10875	COG1570	exodeoxyribonuclease VII activity
C6N67_RS10885	COG0142	geranyltranstransferase activity
C6N67_RS10890	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C6N67_RS10895	COG1438	arginine binding
C6N67_RS10900	COG0497	DNA recombination
C6N67_RS10910	COG0194	GDP metabolic process
C6N67_RS10920	COG0586	Pfam SNARE associated Golgi protein
C6N67_RS10925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C6N67_RS10930	COG1098	S1 RNA binding domain
C6N67_RS11040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6N67_RS11050	COG1271	oxidase subunit
C6N67_RS11055	COG1294	oxidase, subunit
C6N67_RS11060	COG4988	ABC transporter
C6N67_RS11065	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C6N67_RS11070	COG1705	Flagellar rod assembly protein muramidase FlgJ
C6N67_RS11070	COG1388	LysM domain
C6N67_RS11075	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C6N67_RS11090	COG1278	Cold shock
C6N67_RS11095	COG0494	nUDIX hydrolase
C6N67_RS11105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C6N67_RS11110	COG0346	lactoylglutathione lyase activity
C6N67_RS11115	COG0400	carboxylic ester hydrolase activity
C6N67_RS11125	COG0741	lytic transglycosylase activity
C6N67_RS11145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C6N67_RS11150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6N67_RS11155	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6N67_RS11165	COG4120	Belongs to the binding-protein-dependent transport system permease family
C6N67_RS11175	COG0038	chloride channel
C6N67_RS11180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6N67_RS11185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6N67_RS11190	COG1307	EDD domain protein, DegV family
C6N67_RS11195	COG1263	PTS System
C6N67_RS11195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6N67_RS11195	COG2190	(PTS) system
C6N67_RS11210	COG2003	Belongs to the UPF0758 family
C6N67_RS11215	COG1077	Cell shape determining protein MreB Mrl
C6N67_RS11225	COG3338	carbonate dehydratase activity
C6N67_RS11235	COG0765	amino acid transport
C6N67_RS11240	COG1126	abc transporter atp-binding protein
C6N67_RS11245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6N67_RS11250	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6N67_RS11250	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6N67_RS11255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C6N67_RS11260	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C6N67_RS11265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C6N67_RS11280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6N67_RS11290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C6N67_RS11295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C6N67_RS11300	COG0138	bifunctional purine biosynthesis protein purh
C6N67_RS11305	COG0151	Belongs to the GarS family
C6N67_RS11310	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C6N67_RS11325	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6N67_RS11340	COG0833	amino acid
C6N67_RS11350	COG2264	protein methyltransferase activity
C6N67_RS11355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C6N67_RS11370	COG2001	Belongs to the MraZ family
C6N67_RS11375	COG0275	rRNA processing
C6N67_RS11385	COG0768	penicillin binding
C6N67_RS11390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6N67_RS11395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C6N67_RS11400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C6N67_RS11405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C6N67_RS11410	COG0849	cell division
C6N67_RS11420	COG1799	cell septum assembly
C6N67_RS11435	COG3599	regulation of cell shape
C6N67_RS11455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6N67_RS11460	COG0217	transcriptional regulatory protein
C6N67_RS11465	COG2252	PERMEase
C6N67_RS11510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C6N67_RS11515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C6N67_RS11520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6N67_RS11525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C6N67_RS11525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C6N67_RS11530	COG0631	protein serine/threonine phosphatase activity
C6N67_RS11535	COG2815	serine threonine protein kinase
C6N67_RS11535	COG0515	serine threonine protein kinase
C6N67_RS11540	COG1162	GTPase activity
C6N67_RS11545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C6N67_RS11555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C6N67_RS11565	COG1461	Dihydroxyacetone kinase
C6N67_RS11585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C6N67_RS11590	COG0416	fatty acid biosynthetic process
C6N67_RS11595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6N67_RS11600	COG0571	ribonuclease III activity
C6N67_RS11605	COG1196	nuclear chromosome segregation
C6N67_RS11610	COG0552	protein localization to endoplasmic reticulum
C6N67_RS11615	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C6N67_RS11620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C6N67_RS11635	COG0228	four-way junction DNA binding
C6N67_RS11640	COG0582	viral genome integration into host DNA