locus-tag	class	description
Wei3612_RS00010	COG0741	lytic transglycosylase activity
Wei3612_RS00015	COG2814	Major facilitator Superfamily
Wei3612_RS00025	COG1278	Cold shock
Wei3612_RS00030	COG0564	pseudouridine synthase activity
Wei3612_RS00045	COG2309	aminopeptidase activity
Wei3612_RS00080	COG2801	Transposase and inactivated derivatives
Wei3612_RS00120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Wei3612_RS00140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Wei3612_RS00145	COG1216	Glycosyl transferase, family 2
Wei3612_RS00155	COG2246	polysaccharide biosynthetic process
Wei3612_RS00160	COG0463	Glycosyl transferase, family 2
Wei3612_RS00170	COG3475	LICD family
Wei3612_RS00175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Wei3612_RS00185	COG1388	LysM domain
Wei3612_RS00185	COG1134	teichoic acid transport
Wei3612_RS00190	COG1682	transport, permease protein
Wei3612_RS00200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Wei3612_RS00230	COG2801	Transposase and inactivated derivatives
Wei3612_RS00245	COG1705	Flagellar rod assembly protein muramidase FlgJ
Wei3612_RS00245	COG1388	LysM domain
Wei3612_RS00265	COG0024	Methionine aminopeptidase
Wei3612_RS00290	COG0562	UDP-galactopyranose mutase
Wei3612_RS00305	COG1705	Flagellar rod assembly protein muramidase FlgJ
Wei3612_RS00315	COG0463	Glycosyl transferase, family 2
Wei3612_RS00325	COG1216	Glycosyl transferase, family 2
Wei3612_RS00355	COG1420	regulation of RNA biosynthetic process
Wei3612_RS00365	COG0443	Heat shock 70 kDa protein
Wei3612_RS00370	COG0484	heat shock protein binding
Wei3612_RS00385	COG1234	tRNA 3'-trailer cleavage
Wei3612_RS00390	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Wei3612_RS00390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Wei3612_RS00410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Wei3612_RS00415	COG4224	UPF0291 protein
Wei3612_RS00420	COG3763	UPF0154 protein
Wei3612_RS00440	COG0791	NLP P60 protein
Wei3612_RS00440	COG3883	PFAM NLP P60 protein
Wei3612_RS00445	COG0204	Acyl-transferase
Wei3612_RS00450	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Wei3612_RS00455	COG2827	Endonuclease containing a URI domain
Wei3612_RS00460	COG0052	Belongs to the universal ribosomal protein uS2 family
Wei3612_RS00465	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Wei3612_RS00475	COG0233	cytoplasmic translational termination
Wei3612_RS00490	COG0489	protein tyrosine kinase activity
Wei3612_RS00495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Wei3612_RS00500	COG0438	transferase activity, transferring glycosyl groups
Wei3612_RS00510	COG1216	Glycosyl transferase, family 2
Wei3612_RS00525	COG1216	Glycosyl transferase, family 2
Wei3612_RS00530	COG1316	TRANSCRIPTIONal
Wei3612_RS00535	COG0366	Alpha amylase catalytic
Wei3612_RS00535	COG5263	repeat protein
Wei3612_RS00545	COG0004	ammonium transporteR
Wei3612_RS00550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Wei3612_RS00565	COG1136	(ABC) transporter
Wei3612_RS00575	COG0617	tRNA 3'-terminal CCA addition
Wei3612_RS00580	COG0488	(ABC) transporter
Wei3612_RS00585	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Wei3612_RS00595	COG0587	DNA-directed DNA polymerase activity
Wei3612_RS00600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Wei3612_RS00605	COG1490	D-aminoacyl-tRNA deacylase activity
Wei3612_RS00615	COG0475	glutathione-regulated potassium exporter activity
Wei3612_RS00625	COG2996	Protein conserved in bacteria
Wei3612_RS00640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Wei3612_RS00645	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Wei3612_RS00650	COG1187	pseudouridine synthase activity
Wei3612_RS00665	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Wei3612_RS00675	COG0514	ATP-dependent DNA helicase (RecQ)
Wei3612_RS00685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Wei3612_RS00690	COG0539	negative regulation of cytoplasmic translation
Wei3612_RS00695	COG1160	GTP binding
Wei3612_RS00705	COG0351	phosphomethylpyrimidine kinase
Wei3612_RS00710	COG4720	Psort location CytoplasmicMembrane, score
Wei3612_RS00715	COG2807	transmembrane transport
Wei3612_RS00725	COG0420	3'-5' exonuclease activity
Wei3612_RS00730	COG0419	ATPase involved in DNA repair
Wei3612_RS00765	COG0457	Tetratricopeptide repeat
Wei3612_RS00770	COG0071	Belongs to the small heat shock protein (HSP20) family
Wei3612_RS00775	COG2384	SAM-dependent methyltransferase
Wei3612_RS00780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Wei3612_RS00810	COG2801	Transposase and inactivated derivatives
Wei3612_RS00820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Wei3612_RS00825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Wei3612_RS00835	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Wei3612_RS00855	COG0577	efflux transmembrane transporter activity
Wei3612_RS00860	COG1136	(ABC) transporter
Wei3612_RS00875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Wei3612_RS00895	COG4221	oxidoreductase activity
Wei3612_RS00900	COG0531	amino acid
Wei3612_RS00910	COG4708	membrane
Wei3612_RS00915	COG1028	Short-chain dehydrogenase reductase Sdr
Wei3612_RS00945	COG0481	GTPase activity
Wei3612_RS00955	COG0531	amino acid
Wei3612_RS00975	COG2723	6-phospho-beta-galactosidase activity
Wei3612_RS00990	COG0306	phosphate transporter
Wei3612_RS01000	COG1609	Transcriptional regulator
Wei3612_RS01010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Wei3612_RS01010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Wei3612_RS01010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Wei3612_RS01015	COG1105	Belongs to the carbohydrate kinase PfkB family
Wei3612_RS01020	COG1349	DNA-binding transcription factor activity
Wei3612_RS01025	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
Wei3612_RS01030	COG0446	pyridine nucleotide-disulphide oxidoreductase
Wei3612_RS01065	COG2801	Transposase and inactivated derivatives
Wei3612_RS01075	COG1397	ADP-ribosylglycohydrolase
Wei3612_RS01080	COG1719	4-vinyl reductase, 4VR
Wei3612_RS01085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Wei3612_RS01095	COG1131	(ABC) transporter
Wei3612_RS01100	COG0537	adenosine 5'-monophosphoramidase activity
Wei3612_RS01110	COG0363	glucosamine-6-phosphate deaminase activity
Wei3612_RS01115	COG3104	oligopeptide transport
Wei3612_RS01125	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Wei3612_RS01130	COG0439	Biotin carboxylase
Wei3612_RS01140	COG0556	nucleotide-excision repair
Wei3612_RS01160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Wei3612_RS01170	COG0116	Belongs to the methyltransferase superfamily
Wei3612_RS01180	COG3599	regulation of cell shape
Wei3612_RS01185	COG4474	Belongs to the UPF0398 family
Wei3612_RS01190	COG3331	DNA recombination
Wei3612_RS01200	COG3935	DnaD domain protein
Wei3612_RS01205	COG0017	Asparaginyl-tRNA synthetase
Wei3612_RS01215	COG1199	ATP-dependent helicase activity
Wei3612_RS01215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Wei3612_RS01235	COG1304	FMN binding
Wei3612_RS01245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Wei3612_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
Wei3612_RS01255	COG0706	membrane insertase activity
Wei3612_RS01290	COG2801	Transposase and inactivated derivatives
Wei3612_RS01295	COG3942	CHAP domain
Wei3612_RS01295	COG1705	Flagellar rod assembly protein muramidase FlgJ
Wei3612_RS01305	COG5002	protein histidine kinase activity
Wei3612_RS01310	COG0745	RESPONSE REGULATOR receiver
Wei3612_RS01325	COG1484	DNA-dependent DNA replication
Wei3612_RS01335	COG0237	dephospho-CoA kinase activity
Wei3612_RS01340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Wei3612_RS01345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Wei3612_RS01345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Wei3612_RS01350	COG0670	Belongs to the BI1 family
Wei3612_RS01355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Wei3612_RS01365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Wei3612_RS01370	COG1363	Peptidase, m42
Wei3612_RS01375	COG0572	uridine kinase
Wei3612_RS01380	COG5002	protein histidine kinase activity
Wei3612_RS01385	COG0745	RESPONSE REGULATOR receiver
Wei3612_RS01415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Wei3612_RS01420	COG0358	DNA primase activity
Wei3612_RS01425	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Wei3612_RS01430	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Wei3612_RS01440	COG0477	Major facilitator Superfamily
Wei3612_RS01445	COG3480	Lon protease (S16) C-terminal proteolytic domain
Wei3612_RS01450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Wei3612_RS01455	COG0742	ribosomal rna small subunit methyltransferase
Wei3612_RS01460	COG4471	UPF0298 protein
Wei3612_RS01465	COG0772	Belongs to the SEDS family
Wei3612_RS01470	COG1217	gtp-binding protein TYPA
Wei3612_RS01475	COG0483	inositol monophosphate 1-phosphatase activity
Wei3612_RS01480	COG4476	Belongs to the UPF0223 family
Wei3612_RS01485	COG0242	peptide deformylase activity
Wei3612_RS01500	COG5503	Protein of unknown function (DUF1447)
Wei3612_RS01520	COG1011	Hydrolase
Wei3612_RS01525	COG1597	lipid kinase activity
Wei3612_RS01530	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Wei3612_RS01535	COG1464	Belongs to the NlpA lipoprotein family
Wei3612_RS01540	COG0446	pyridine nucleotide-disulphide oxidoreductase
Wei3612_RS01550	COG3448	diguanylate cyclase activity
Wei3612_RS01550	COG4175	Glycine betaine
Wei3612_RS01570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Wei3612_RS01580	COG4974	Belongs to the 'phage' integrase family
Wei3612_RS01585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Wei3612_RS01595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Wei3612_RS01605	COG4479	Belongs to the UPF0346 family
Wei3612_RS01615	COG2755	lipolytic protein G-D-S-L family
Wei3612_RS01620	COG1307	EDD domain protein, DegV family
Wei3612_RS01625	COG1307	EDD domain protein, DegV family
Wei3612_RS01630	COG2270	Major facilitator Superfamily
Wei3612_RS01645	COG3142	Participates in the control of copper homeostasis
Wei3612_RS01650	COG1293	RNA-binding protein homologous to eukaryotic snRNP
Wei3612_RS01655	COG0196	riboflavin kinase activity
Wei3612_RS01670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Wei3612_RS01675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Wei3612_RS01680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Wei3612_RS01690	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Wei3612_RS01695	COG0195	Participates in both transcription termination and antitermination
Wei3612_RS01700	COG0779	Required for maturation of 30S ribosomal subunits
Wei3612_RS01715	COG1304	FMN binding
Wei3612_RS01735	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Wei3612_RS01740	COG0738	Major facilitator superfamily
Wei3612_RS01745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Wei3612_RS01760	COG4684	Psort location CytoplasmicMembrane, score
Wei3612_RS01765	COG1033	growth of symbiont in host cell
Wei3612_RS01765	COG2409	Drug exporters of the RND superfamily
Wei3612_RS01785	COG1621	beta-fructofuranosidase activity
Wei3612_RS01795	COG0384	phenazine biosynthesis protein PhzF
Wei3612_RS01805	COG4753	response regulator
Wei3612_RS01805	COG2207	Transcriptional regulator
Wei3612_RS01820	COG2801	Transposase and inactivated derivatives
Wei3612_RS01870	COG0456	acetyltransferase
Wei3612_RS01880	COG2239	Acts as a magnesium transporter
Wei3612_RS01885	COG0564	pseudouridine synthase activity
Wei3612_RS01890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Wei3612_RS01895	COG2357	RelA SpoT domain protein
Wei3612_RS01910	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Wei3612_RS01915	COG1518	maintenance of DNA repeat elements
Wei3612_RS01920	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
Wei3612_RS01935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Wei3612_RS01940	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Wei3612_RS01945	COG0546	phosphoglycolate phosphatase activity
Wei3612_RS02020	COG1940	carbohydrate kinase activity
Wei3612_RS02030	COG1028	Short-chain dehydrogenase reductase Sdr
Wei3612_RS02050	COG0352	thiamine-phosphate diphosphorylase activity
Wei3612_RS02055	COG0351	phosphomethylpyrimidine kinase
Wei3612_RS02060	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Wei3612_RS02070	COG1464	Belongs to the NlpA lipoprotein family
Wei3612_RS02085	COG0436	Aminotransferase
Wei3612_RS02090	COG0277	FAD linked oxidase domain protein
Wei3612_RS02140	COG2801	Transposase and inactivated derivatives
Wei3612_RS02145	COG0028	Belongs to the TPP enzyme family
Wei3612_RS02180	COG3201	nicotinamide mononucleotide transporter
Wei3612_RS02185	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Wei3612_RS02210	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Wei3612_RS02225	COG1473	amidohydrolase
Wei3612_RS02230	COG3527	Alpha-acetolactate decarboxylase
Wei3612_RS02235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Wei3612_RS02240	COG0187	DNA topoisomerase II activity
Wei3612_RS02245	COG3118	belongs to the thioredoxin family
Wei3612_RS02270	COG1193	negative regulation of DNA recombination
Wei3612_RS02290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Wei3612_RS02295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Wei3612_RS02300	COG0544	peptidyl-prolyl cis-trans isomerase activity
Wei3612_RS02325	COG0268	Binds directly to 16S ribosomal RNA
Wei3612_RS02330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Wei3612_RS02335	COG1466	dna polymerase III delta subunit
Wei3612_RS02340	COG2333	competence protein COMEC
Wei3612_RS02340	COG0658	competence protein
Wei3612_RS02350	COG3906	Belongs to the UPF0473 family
Wei3612_RS02370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Wei3612_RS02375	COG1929	Belongs to the glycerate kinase type-1 family
Wei3612_RS02380	COG0513	Belongs to the DEAD box helicase family
Wei3612_RS02385	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Wei3612_RS02390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Wei3612_RS02395	COG1862	Preprotein translocase
Wei3612_RS02400	COG0343	queuine tRNA-ribosyltransferase activity
Wei3612_RS02435	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Wei3612_RS02440	COG2255	four-way junction helicase activity
Wei3612_RS02445	COG0632	four-way junction helicase activity
Wei3612_RS02450	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Wei3612_RS02455	COG0516	GMP reductase activity
Wei3612_RS02455	COG0517	IMP dehydrogenase activity
Wei3612_RS02460	COG0517	IMP dehydrogenase activity
Wei3612_RS02460	COG0516	GMP reductase activity
Wei3612_RS02475	COG1739	Uncharacterized protein family UPF0029
Wei3612_RS02485	COG0322	excinuclease ABC activity
Wei3612_RS02495	COG1668	transmembrane transport
Wei3612_RS02500	COG4152	abc transporter atp-binding protein
Wei3612_RS02510	COG1674	ftsk spoiiie
Wei3612_RS02520	COG0628	permease
Wei3612_RS02525	COG2706	6-phosphogluconolactonase activity
Wei3612_RS02545	COG0751	glycine-tRNA ligase activity
Wei3612_RS02550	COG0752	glycyl-tRNA synthetase alpha subunit
Wei3612_RS02560	COG1381	Involved in DNA repair and RecF pathway recombination
Wei3612_RS02565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Wei3612_RS02570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Wei3612_RS02575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Wei3612_RS02580	COG1702	phosphate starvation-inducible protein PhoH
Wei3612_RS02585	COG1610	YqeY-like protein
Wei3612_RS02590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Wei3612_RS02595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Wei3612_RS02610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Wei3612_RS02615	COG0124	histidyl-tRNA synthetase
Wei3612_RS02620	COG0860	N-Acetylmuramoyl-L-alanine amidase
Wei3612_RS02635	COG3425	synthase
Wei3612_RS02640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Wei3612_RS02715	COG0006	proline dipeptidase activity
Wei3612_RS02720	COG1609	Transcriptional regulator
Wei3612_RS02735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Wei3612_RS02740	COG1164	Oligoendopeptidase f
Wei3612_RS02750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Wei3612_RS02755	COG2723	6-phospho-beta-galactosidase activity
Wei3612_RS02760	COG1447	Phosphotransferase system cellobiose-specific component IIA
Wei3612_RS02765	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Wei3612_RS02770	COG2723	6-phospho-beta-galactosidase activity
Wei3612_RS02775	COG4862	establishment of competence for transformation
Wei3612_RS02780	COG1393	Belongs to the ArsC family
Wei3612_RS02785	COG3853	Toxic anion resistance protein (TelA)
Wei3612_RS02850	COG0561	phosphatase activity
Wei3612_RS02855	COG1970	mechanosensitive ion channel activity
Wei3612_RS02860	COG1428	Deoxynucleoside kinase
Wei3612_RS02870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Wei3612_RS02875	COG1942	4-Oxalocrotonate Tautomerase
Wei3612_RS02880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Wei3612_RS02890	COG0335	large ribosomal subunit rRNA binding
Wei3612_RS02895	COG0336	Belongs to the RNA methyltransferase TrmD family
Wei3612_RS02900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Wei3612_RS02905	COG0588	phosphoglycerate mutase activity
Wei3612_RS03020	COG1783	phage Terminase large subunit
Wei3612_RS03085	COG0629	single-stranded DNA binding
Wei3612_RS03135	COG1396	sequence-specific DNA binding
Wei3612_RS03150	COG0582	viral genome integration into host DNA
Wei3612_RS03155	COG0228	four-way junction DNA binding
Wei3612_RS03170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Wei3612_RS03175	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Wei3612_RS03180	COG0552	protein localization to endoplasmic reticulum
Wei3612_RS03185	COG1196	nuclear chromosome segregation
Wei3612_RS03190	COG0571	ribonuclease III activity
Wei3612_RS03195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Wei3612_RS03200	COG0416	fatty acid biosynthetic process
Wei3612_RS03205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Wei3612_RS03215	COG0438	transferase activity, transferring glycosyl groups
Wei3612_RS03225	COG1461	Dihydroxyacetone kinase
Wei3612_RS03235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Wei3612_RS03245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Wei3612_RS03250	COG1162	GTPase activity
Wei3612_RS03255	COG2815	serine threonine protein kinase
Wei3612_RS03255	COG0515	serine threonine protein kinase
Wei3612_RS03260	COG0631	protein serine/threonine phosphatase activity
Wei3612_RS03265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Wei3612_RS03265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Wei3612_RS03270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Wei3612_RS03275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Wei3612_RS03280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Wei3612_RS03320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Wei3612_RS03325	COG2252	PERMEase
Wei3612_RS03330	COG0217	transcriptional regulatory protein
Wei3612_RS03335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Wei3612_RS03355	COG3599	regulation of cell shape
Wei3612_RS03370	COG1799	cell septum assembly
Wei3612_RS03380	COG0849	cell division
Wei3612_RS03385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Wei3612_RS03390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Wei3612_RS03395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Wei3612_RS03400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Wei3612_RS03405	COG0768	penicillin binding
Wei3612_RS03415	COG0275	rRNA processing
Wei3612_RS03420	COG2001	Belongs to the MraZ family
Wei3612_RS03430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Wei3612_RS03435	COG2264	protein methyltransferase activity
Wei3612_RS03445	COG0833	amino acid
Wei3612_RS03465	COG0446	pyridine nucleotide-disulphide oxidoreductase
Wei3612_RS03485	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Wei3612_RS03490	COG0151	Belongs to the GarS family
Wei3612_RS03495	COG0138	bifunctional purine biosynthesis protein purh
Wei3612_RS03500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Wei3612_RS03505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Wei3612_RS03515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Wei3612_RS03520	COG0047	phosphoribosylformylglycinamidine synthase activity
Wei3612_RS03525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Wei3612_RS03530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Wei3612_RS03535	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Wei3612_RS03540	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Wei3612_RS03545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Wei3612_RS03545	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Wei3612_RS03550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Wei3612_RS03555	COG1126	abc transporter atp-binding protein
Wei3612_RS03560	COG0765	amino acid transport
Wei3612_RS03570	COG3338	carbonate dehydratase activity
Wei3612_RS03580	COG1077	Cell shape determining protein MreB Mrl
Wei3612_RS03585	COG2003	Belongs to the UPF0758 family
Wei3612_RS03600	COG2190	(PTS) system
Wei3612_RS03600	COG1263	PTS System
Wei3612_RS03600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Wei3612_RS03605	COG1307	EDD domain protein, DegV family
Wei3612_RS03610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Wei3612_RS03615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Wei3612_RS03620	COG0038	chloride channel
Wei3612_RS03630	COG4120	Belongs to the binding-protein-dependent transport system permease family
Wei3612_RS03640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Wei3612_RS03645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Wei3612_RS03650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Wei3612_RS03670	COG0741	lytic transglycosylase activity
Wei3612_RS03675	COG2801	Transposase and inactivated derivatives
Wei3612_RS03695	COG0400	carboxylic ester hydrolase activity
Wei3612_RS03700	COG0346	lactoylglutathione lyase activity
Wei3612_RS03705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Wei3612_RS03715	COG0494	nUDIX hydrolase
Wei3612_RS03720	COG1278	Cold shock
Wei3612_RS03735	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Wei3612_RS03740	COG1705	Flagellar rod assembly protein muramidase FlgJ
Wei3612_RS03740	COG1388	LysM domain
Wei3612_RS03745	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Wei3612_RS03750	COG4988	ABC transporter
Wei3612_RS03755	COG1294	oxidase, subunit
Wei3612_RS03760	COG1271	oxidase subunit
Wei3612_RS03765	COG4684	Psort location CytoplasmicMembrane, score
Wei3612_RS03880	COG1098	S1 RNA binding domain
Wei3612_RS03885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Wei3612_RS03890	COG0586	Pfam SNARE associated Golgi protein
Wei3612_RS03900	COG0194	GDP metabolic process
Wei3612_RS03910	COG0497	DNA recombination
Wei3612_RS03915	COG1438	arginine binding
Wei3612_RS03920	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Wei3612_RS03925	COG0142	geranyltranstransferase activity
Wei3612_RS03935	COG1570	exodeoxyribonuclease VII activity
Wei3612_RS03940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Wei3612_RS03945	COG4720	Psort location CytoplasmicMembrane, score
Wei3612_RS03960	COG1136	(ABC) transporter
Wei3612_RS03965	COG0577	efflux transmembrane transporter activity
Wei3612_RS03975	COG0776	regulation of translation
Wei3612_RS03980	COG0363	glucosamine-6-phosphate deaminase activity
Wei3612_RS03985	COG3764	Sortase (surface protein transpeptidase)
Wei3612_RS03990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Wei3612_RS04080	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Wei3612_RS04085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Wei3612_RS04095	COG1323	Belongs to the UPF0348 family
Wei3612_RS04100	COG2226	methyltransferase
Wei3612_RS04105	COG0799	negative regulation of ribosome biogenesis
Wei3612_RS04110	COG1713	HD superfamily hydrolase involved in NAD metabolism
Wei3612_RS04115	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Wei3612_RS04125	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Wei3612_RS04130	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Wei3612_RS04135	COG1181	Belongs to the D-alanine--D-alanine ligase family
Wei3612_RS04145	COG0531	amino acid
Wei3612_RS04150	COG0459	protein refolding
Wei3612_RS04155	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Wei3612_RS04160	COG0488	(ABC) transporter
Wei3612_RS04185	COG2801	Transposase and inactivated derivatives
Wei3612_RS04190	COG0285	dihydrofolate synthase activity
Wei3612_RS04200	COG0525	valine-tRNA ligase activity
Wei3612_RS04230	COG1272	protein, Hemolysin III
Wei3612_RS04350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Wei3612_RS04360	COG5506	Protein of unknown function (DUF1694)
Wei3612_RS04370	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Wei3612_RS04405	COG2137	regulation of response to DNA damage stimulus
Wei3612_RS04410	COG0704	Plays a role in the regulation of phosphate uptake
Wei3612_RS04415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Wei3612_RS04420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Wei3612_RS04425	COG0581	inorganic phosphate transmembrane transporter activity
Wei3612_RS04430	COG0573	inorganic phosphate transmembrane transporter activity
Wei3612_RS04465	COG0673	inositol 2-dehydrogenase activity
Wei3612_RS04470	COG4166	transmembrane transport
Wei3612_RS04475	COG0647	UMP catabolic process
Wei3612_RS04480	COG4470	Protein conserved in bacteria
Wei3612_RS04485	COG0737	Belongs to the 5'-nucleotidase family
Wei3612_RS04515	COG4948	Mandelate Racemase Muconate Lactonizing
Wei3612_RS04520	COG0596	Alpha beta hydrolase
Wei3612_RS04525	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Wei3612_RS04530	COG1169	isochorismate synthase
Wei3612_RS04535	COG0778	Nitroreductase
Wei3612_RS04565	COG1472	Belongs to the glycosyl hydrolase 3 family
Wei3612_RS04570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Wei3612_RS04575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Wei3612_RS04600	COG0174	glutamine synthetase
Wei3612_RS04605	COG0789	Transcriptional regulator
Wei3612_RS04610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Wei3612_RS04615	COG0584	glycerophosphoryl diester phosphodiesterase
Wei3612_RS04635	COG3942	CHAP domain
Wei3612_RS04650	COG1940	carbohydrate kinase activity
Wei3612_RS04665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Wei3612_RS04670	COG0768	penicillin binding
Wei3612_RS04680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Wei3612_RS04685	COG0514	ATP-dependent DNA helicase (RecQ)
Wei3612_RS04690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Wei3612_RS04695	COG0072	phenylalanine-tRNA ligase activity
Wei3612_RS04695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Wei3612_RS04700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Wei3612_RS04705	COG1733	regulation of RNA biosynthetic process
Wei3612_RS04715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Wei3612_RS04730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Wei3612_RS04735	COG0653	protein targeting
Wei3612_RS04745	COG4956	integral membrane protein (PIN domain superfamily)
Wei3612_RS04755	COG0756	dUTP diphosphatase activity
Wei3612_RS04765	COG0791	NLP P60 protein
Wei3612_RS04770	COG1388	LysM domain
Wei3612_RS04770	COG3942	CHAP domain
Wei3612_RS04780	COG3527	Alpha-acetolactate decarboxylase
Wei3612_RS04785	COG0028	Belongs to the TPP enzyme family
Wei3612_RS04790	COG0039	L-malate dehydrogenase activity
Wei3612_RS04810	COG1914	H( )-stimulated, divalent metal cation uptake system
Wei3612_RS04820	COG1263	PTS System
Wei3612_RS04820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Wei3612_RS04835	COG0740	serine-type endopeptidase activity
Wei3612_RS04840	COG1481	regulation of sporulation
Wei3612_RS04845	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Wei3612_RS04860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Wei3612_RS04865	COG2814	Major facilitator Superfamily
Wei3612_RS04885	COG0671	phosphoesterase, PA-phosphatase related
Wei3612_RS04895	COG0366	Alpha amylase catalytic
Wei3612_RS04910	COG1573	uracil-dna glycosylase
Wei3612_RS04920	COG0028	Belongs to the TPP enzyme family
Wei3612_RS04945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Wei3612_RS04950	COG0101	tRNA pseudouridine synthase activity
Wei3612_RS04960	COG1122	ATPase activity
Wei3612_RS04965	COG1122	ATPase activity
Wei3612_RS04975	COG1252	NADH dehydrogenase
Wei3612_RS04980	COG0803	Belongs to the bacterial solute-binding protein 9 family
Wei3612_RS04985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Wei3612_RS04990	COG1121	(ABC) transporter
Wei3612_RS04995	COG2801	Transposase and inactivated derivatives
Wei3612_RS05015	COG0222	ribosome binding
Wei3612_RS05020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Wei3612_RS05025	COG0081	regulation of translation
Wei3612_RS05030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Wei3612_RS05035	COG0250	Participates in transcription elongation, termination and antitermination
Wei3612_RS05040	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Wei3612_RS05055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Wei3612_RS05060	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Wei3612_RS05065	COG1854	S-ribosylhomocysteine lyase activity
Wei3612_RS05070	COG1464	Belongs to the NlpA lipoprotein family
Wei3612_RS05075	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Wei3612_RS05080	COG0626	cystathionine gamma-synthase activity
Wei3612_RS05085	COG0215	cysteine-tRNA ligase activity
Wei3612_RS05090	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Wei3612_RS05095	COG0039	L-malate dehydrogenase activity
Wei3612_RS05100	COG0471	metal ion transport
Wei3612_RS05105	COG1053	succinate dehydrogenase
Wei3612_RS05115	COG0583	DNA-binding transcription factor activity
Wei3612_RS05140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Wei3612_RS05155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Wei3612_RS05180	COG0203	ribosomal protein L17
Wei3612_RS05185	COG0202	RNA polymerase activity
Wei3612_RS05190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Wei3612_RS05195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Wei3612_RS05200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Wei3612_RS05205	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Wei3612_RS05220	COG0200	Binds to the 23S rRNA
Wei3612_RS05225	COG1841	ribosomal large subunit assembly
Wei3612_RS05230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Wei3612_RS05235	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Wei3612_RS05240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Wei3612_RS05245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Wei3612_RS05250	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Wei3612_RS05255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Wei3612_RS05260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Wei3612_RS05270	COG0255	Belongs to the universal ribosomal protein uL29 family
Wei3612_RS05275	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Wei3612_RS05280	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Wei3612_RS05285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Wei3612_RS05290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Wei3612_RS05295	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Wei3612_RS05300	COG0089	rRNA binding
Wei3612_RS05310	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Wei3612_RS05315	COG0051	transcription antitermination factor activity, RNA binding
Wei3612_RS05320	COG0142	geranyltranstransferase activity
Wei3612_RS05325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Wei3612_RS05335	COG0456	acetyltransferase
Wei3612_RS05340	COG1214	PFAM Peptidase M22, glycoprotease
Wei3612_RS05345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Wei3612_RS05365	COG3870	Protein conserved in bacteria
Wei3612_RS05370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Wei3612_RS05395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Wei3612_RS05405	COG0590	tRNA wobble adenosine to inosine editing
Wei3612_RS05410	COG2813	Specifically methylates the guanine in position
Wei3612_RS05420	COG2807	transmembrane transport
Wei3612_RS05430	COG3620	sequence-specific DNA binding
Wei3612_RS05475	COG0500	methyltransferase
Wei3612_RS05480	COG1309	transcriptional regulator
Wei3612_RS05505	COG1979	alcohol dehydrogenase
Wei3612_RS05525	COG0085	RNA polymerase activity
Wei3612_RS05530	COG0542	response to heat
Wei3612_RS05535	COG4463	regulation of RNA biosynthetic process
Wei3612_RS05560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Wei3612_RS05565	COG1428	Deoxynucleoside kinase
Wei3612_RS05570	COG1876	peptidase activity
Wei3612_RS05575	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Wei3612_RS05580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Wei3612_RS05585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Wei3612_RS05590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Wei3612_RS05595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Wei3612_RS05600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Wei3612_RS05605	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Wei3612_RS05610	COG0356	it plays a direct role in the translocation of protons across the membrane
Wei3612_RS05615	COG2233	PERMEase
Wei3612_RS05625	COG0702	epimerase
Wei3612_RS05630	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Wei3612_RS05635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Wei3612_RS05640	COG0009	L-threonylcarbamoyladenylate synthase
Wei3612_RS05645	COG2890	protein-(glutamine-N5) methyltransferase activity
Wei3612_RS05650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Wei3612_RS05655	COG1435	thymidine kinase activity
Wei3612_RS05665	COG3442	glutamine amidotransferase
Wei3612_RS05670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Wei3612_RS05675	COG1482	cell wall glycoprotein biosynthetic process
Wei3612_RS05715	COG1373	ATPase (AAA superfamily
Wei3612_RS05720	COG1132	(ABC) transporter
Wei3612_RS05725	COG1132	(ABC) transporter
Wei3612_RS05740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Wei3612_RS05745	COG0588	phosphoglycerate mutase activity
Wei3612_RS05765	COG0708	Exodeoxyribonuclease III
Wei3612_RS05770	COG1373	ATPase (AAA superfamily
Wei3612_RS05780	COG1454	alcohol dehydrogenase
Wei3612_RS05780	COG1012	belongs to the aldehyde dehydrogenase family
Wei3612_RS05790	COG3590	peptidase
Wei3612_RS05835	COG5039	Polysaccharide pyruvyl transferase
Wei3612_RS05855	COG1216	Glycosyl transferase, family 2
Wei3612_RS05865	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Wei3612_RS05870	COG2188	Transcriptional regulator
Wei3612_RS05875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Wei3612_RS05880	COG2814	Major facilitator Superfamily
Wei3612_RS05885	COG1418	mRNA catabolic process
Wei3612_RS05905	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Wei3612_RS05910	COG1215	transferase activity, transferring glycosyl groups
Wei3612_RS05940	COG0765	amino acid transport
Wei3612_RS05965	COG0656	L-ascorbic acid biosynthetic process
Wei3612_RS05970	COG2160	L-arabinose isomerase activity
Wei3612_RS05990	COG3940	Belongs to the glycosyl hydrolase 43 family
Wei3612_RS06005	COG0534	Mate efflux family protein
Wei3612_RS06010	COG0488	(ABC) transporter
Wei3612_RS06015	COG1373	ATPase (AAA superfamily
Wei3612_RS06020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Wei3612_RS06025	COG1121	(ABC) transporter
Wei3612_RS06035	COG1846	Transcriptional regulator
Wei3612_RS06040	COG2755	lipolytic protein G-D-S-L family
Wei3612_RS06040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Wei3612_RS06045	COG3091	SprT-like family
Wei3612_RS06090	COG4975	Glucose uptake
Wei3612_RS06095	COG0477	Major facilitator Superfamily
Wei3612_RS06100	COG3104	oligopeptide transport
Wei3612_RS06155	COG2801	Transposase and inactivated derivatives
Wei3612_RS06160	COG1686	Belongs to the peptidase S11 family
Wei3612_RS06170	COG0745	RESPONSE REGULATOR receiver
Wei3612_RS06180	COG0012	GTP binding
Wei3612_RS06185	COG4481	Protein conserved in bacteria
Wei3612_RS06190	COG1475	DNA binding
Wei3612_RS06195	COG1192	Involved in chromosome partitioning
Wei3612_RS06200	COG0357	Ribosomal RNA small subunit methyltransferase G
Wei3612_RS06210	COG1194	a g-specific adenine glycosylase
Wei3612_RS06215	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Wei3612_RS06255	COG5002	protein histidine kinase activity
Wei3612_RS06260	COG0745	RESPONSE REGULATOR receiver
Wei3612_RS06275	COG0318	PFAM AMP-dependent synthetase and ligase
Wei3612_RS06280	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Wei3612_RS06285	COG2050	protein possibly involved in aromatic compounds catabolism
Wei3612_RS06290	COG1335	isochorismatase
Wei3612_RS06295	COG2226	methyltransferase
Wei3612_RS06305	COG4443	Transcriptional Coactivator p15 (PC4)
Wei3612_RS06310	COG0252	asparaginase activity
Wei3612_RS06315	COG0531	amino acid
Wei3612_RS06320	COG1113	amino acid transport
Wei3612_RS06325	COG0531	amino acid
Wei3612_RS06335	COG4975	Glucose uptake
Wei3612_RS06340	COG0477	Major facilitator Superfamily
Wei3612_RS06350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Wei3612_RS06355	COG2267	carboxylic ester hydrolase activity
Wei3612_RS06360	COG4166	transmembrane transport
Wei3612_RS06365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Wei3612_RS06375	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Wei3612_RS06385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Wei3612_RS06395	COG3223	Belongs to the PsiE family
Wei3612_RS06405	COG0531	amino acid
Wei3612_RS06410	COG1228	amidohydrolase
Wei3612_RS06425	COG2070	2-Nitropropane dioxygenase
Wei3612_RS06435	COG0583	DNA-binding transcription factor activity
Wei3612_RS06440	COG2855	membrane
Wei3612_RS06450	COG2855	membrane
Wei3612_RS06460	COG0456	acetyltransferase
Wei3612_RS06460	COG0454	-acetyltransferase
Wei3612_RS06465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Wei3612_RS06490	COG1113	amino acid transport
Wei3612_RS06520	COG0628	permease
Wei3612_RS06530	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Wei3612_RS06530	COG0392	lysyltransferase activity
Wei3612_RS06540	COG1254	Belongs to the acylphosphatase family
Wei3612_RS06545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Wei3612_RS06550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Wei3612_RS06555	COG0765	amino acid transport
Wei3612_RS06560	COG1126	abc transporter atp-binding protein
Wei3612_RS06570	COG1131	(ABC) transporter
Wei3612_RS06580	COG0390	transport system, permease component
Wei3612_RS06585	COG4619	ABC transporter
Wei3612_RS06595	COG0656	L-ascorbic acid biosynthetic process
Wei3612_RS06605	COG1132	(ABC) transporter
Wei3612_RS06610	COG1846	Transcriptional regulator
Wei3612_RS06635	COG0697	spore germination
Wei3612_RS06645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Wei3612_RS06655	COG1028	Short-chain dehydrogenase reductase Sdr
Wei3612_RS06660	COG0789	Transcriptional regulator
Wei3612_RS06670	COG1131	(ABC) transporter
Wei3612_RS06690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Wei3612_RS06695	COG0505	Belongs to the CarA family
Wei3612_RS06700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Wei3612_RS06705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Wei3612_RS06710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Wei3612_RS06715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Wei3612_RS06720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Wei3612_RS06725	COG0165	Argininosuccinate lyase
Wei3612_RS06730	COG0137	argininosuccinate synthase activity
Wei3612_RS06735	COG1744	ABC transporter substrate-binding protein PnrA-like
Wei3612_RS06745	COG0561	phosphatase activity
Wei3612_RS06750	COG0561	phosphatase activity
Wei3612_RS06765	COG0697	spore germination
Wei3612_RS06795	COG2723	6-phospho-beta-galactosidase activity
Wei3612_RS06800	COG0517	IMP dehydrogenase activity
Wei3612_RS06800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Wei3612_RS06830	COG1476	TRANSCRIPTIONal
Wei3612_RS06855	COG1881	PFAM PEBP family protein
Wei3612_RS06895	COG2252	PERMEase
Wei3612_RS06900	COG3152	Membrane
Wei3612_RS06920	COG0328	RNA-DNA hybrid ribonuclease activity
Wei3612_RS06930	COG0561	phosphatase activity
Wei3612_RS06935	COG2409	Drug exporters of the RND superfamily
Wei3612_RS06935	COG1033	growth of symbiont in host cell
Wei3612_RS06940	COG0577	efflux transmembrane transporter activity
Wei3612_RS06945	COG1136	(ABC) transporter
Wei3612_RS06955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Wei3612_RS06960	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Wei3612_RS06970	COG0446	pyridine nucleotide-disulphide oxidoreductase
Wei3612_RS06975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Wei3612_RS06985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Wei3612_RS07005	COG1113	amino acid transport
Wei3612_RS07010	COG0569	domain protein
Wei3612_RS07025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Wei3612_RS07035	COG1120	ATPase activity
Wei3612_RS07045	COG0706	membrane insertase activity
Wei3612_RS07050	COG0594	ribonuclease P activity
Wei3612_RS07055	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Wei3612_RS07060	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Wei3612_RS07065	COG0592	DNA-directed DNA polymerase activity
Wei3612_RS07070	COG2501	S4 domain
Wei3612_RS07075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Wei3612_RS07080	COG0187	DNA topoisomerase II activity
Wei3612_RS07095	COG2153	protein acetylation
Wei3612_RS07100	COG1368	sulfuric ester hydrolase activity
Wei3612_RS07120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Wei3612_RS07180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Wei3612_RS07180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Wei3612_RS07190	COG0084	hydrolase, TatD family'
Wei3612_RS07195	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
Wei3612_RS07200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Wei3612_RS07205	COG1253	flavin adenine dinucleotide binding
Wei3612_RS07210	COG1253	flavin adenine dinucleotide binding
Wei3612_RS07215	COG4466	Protein conserved in bacteria
Wei3612_RS07220	COG2131	deaminase
Wei3612_RS07230	COG1316	TRANSCRIPTIONal
Wei3612_RS07235	COG1263	PTS System
Wei3612_RS07235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Wei3612_RS07250	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Wei3612_RS07265	COG0737	Belongs to the 5'-nucleotidase family
Wei3612_RS07270	COG2801	Transposase and inactivated derivatives
Wei3612_RS07285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Wei3612_RS07290	COG1983	PspC domain protein
Wei3612_RS07295	COG1695	Transcriptional regulator
Wei3612_RS07310	COG1968	undecaprenyl-diphosphatase activity
Wei3612_RS07315	COG2818	Glycosylase
Wei3612_RS07340	COG3507	Belongs to the glycosyl hydrolase 43 family
Wei3612_RS07345	COG2211	Major facilitator Superfamily
Wei3612_RS07355	COG2115	Belongs to the xylose isomerase family
Wei3612_RS07365	COG0667	Aldo Keto reductase
Wei3612_RS07380	COG0477	Major facilitator Superfamily
Wei3612_RS07385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Wei3612_RS07400	COG1309	transcriptional regulator
Wei3612_RS07405	COG1511	domain protein
Wei3612_RS07405	COG1511	domain protein
Wei3612_RS07410	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Wei3612_RS07420	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Wei3612_RS07425	COG0297	glycogen (starch) synthase activity
Wei3612_RS07430	COG0058	SHG alpha-glucan phosphorylase activity
Wei3612_RS07440	COG0193	aminoacyl-tRNA hydrolase activity
Wei3612_RS07445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Wei3612_RS07450	COG2244	polysaccharide biosynthetic process
Wei3612_RS07455	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Wei3612_RS07465	COG0037	tRNA processing
Wei3612_RS07480	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Wei3612_RS07485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Wei3612_RS07550	COG2261	transglycosylase associated protein
Wei3612_RS07555	COG0656	L-ascorbic acid biosynthetic process
Wei3612_RS07565	COG1737	Transcriptional regulator
Wei3612_RS07570	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Wei3612_RS07620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Wei3612_RS07635	COG1216	Glycosyl transferase, family 2
Wei3612_RS07645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Wei3612_RS07650	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Wei3612_RS07655	COG1447	Phosphotransferase system cellobiose-specific component IIA
Wei3612_RS07660	COG2723	6-phospho-beta-galactosidase activity
Wei3612_RS07665	COG2723	6-phospho-beta-galactosidase activity
Wei3612_RS07670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Wei3612_RS07680	COG0436	Aminotransferase
Wei3612_RS07685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Wei3612_RS07700	COG2190	(PTS) system
Wei3612_RS07700	COG2211	Major facilitator Superfamily
Wei3612_RS07705	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Wei3612_RS07710	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
Wei3612_RS07715	COG0444	Belongs to the ABC transporter superfamily
Wei3612_RS07720	COG4608	Belongs to the ABC transporter superfamily
Wei3612_RS07725	COG0601	transmembrane transport
Wei3612_RS07730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Wei3612_RS07735	COG0747	negative chemotaxis
Wei3612_RS07740	COG1132	(ABC) transporter
Wei3612_RS07745	COG1132	(ABC) transporter
Wei3612_RS07760	COG1956	GAF domain-containing protein
Wei3612_RS07775	COG2233	PERMEase
Wei3612_RS07780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Wei3612_RS07785	COG4989	oxidoreductase activity
Wei3612_RS07790	COG1620	l-lactate permease
Wei3612_RS07800	COG1028	Short-chain dehydrogenase reductase Sdr
Wei3612_RS07805	COG2084	Dehydrogenase
Wei3612_RS07835	COG0438	transferase activity, transferring glycosyl groups
Wei3612_RS07900	COG1914	H( )-stimulated, divalent metal cation uptake system
Wei3612_RS07920	COG2814	Major facilitator Superfamily
Wei3612_RS07975	COG3842	ATPase activity
Wei3612_RS07980	COG1175	transmembrane transport
Wei3612_RS07985	COG0395	ABC-type sugar transport system, permease component
Wei3612_RS08000	COG0308	aminopeptidase N
Wei3612_RS08005	COG0542	response to heat
Wei3612_RS08010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Wei3612_RS08015	COG2040	homocysteine
Wei3612_RS08020	COG0833	amino acid
Wei3612_RS08025	COG0308	aminopeptidase N
Wei3612_RS08045	COG2207	Transcriptional regulator
Wei3612_RS08060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Wei3612_RS08065	COG0745	RESPONSE REGULATOR receiver
Wei3612_RS08070	COG2205	protein histidine kinase activity
Wei3612_RS08080	COG1316	TRANSCRIPTIONal
Wei3612_RS08090	COG0024	Methionine aminopeptidase
Wei3612_RS08100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Wei3612_RS08115	COG2723	6-phospho-beta-galactosidase activity
Wei3612_RS08140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Wei3612_RS08150	COG0671	phosphoesterase, PA-phosphatase related
Wei3612_RS08155	COG0495	leucyl-tRNA aminoacylation
Wei3612_RS08160	COG0438	transferase activity, transferring glycosyl groups
Wei3612_RS08170	COG2244	polysaccharide biosynthetic process
Wei3612_RS08185	COG0626	cystathionine gamma-synthase activity
Wei3612_RS08190	COG1902	pentaerythritol trinitrate reductase activity
Wei3612_RS08200	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Wei3612_RS08205	COG0531	amino acid
Wei3612_RS08210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Wei3612_RS08225	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Wei3612_RS08230	COG1074	ATP-dependent DNA helicase activity
Wei3612_RS08235	COG1064	alcohol dehydrogenase
Wei3612_RS08240	COG2814	Major facilitator Superfamily
Wei3612_RS08255	COG1051	belongs to the nudix hydrolase family
Wei3612_RS08260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Wei3612_RS08270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Wei3612_RS08285	COG0360	Binds together with S18 to 16S ribosomal RNA
Wei3612_RS08290	COG0629	single-stranded DNA binding
Wei3612_RS08295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Wei3612_RS08325	COG0745	RESPONSE REGULATOR receiver
Wei3612_RS08345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Wei3612_RS08350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Wei3612_RS08360	COG1078	dGTPase activity
Wei3612_RS08365	COG0561	phosphatase activity
Wei3612_RS08370	COG3343	RNA polymerase activity
Wei3612_RS08380	COG0504	CTP synthase activity
Wei3612_RS08385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Wei3612_RS08400	COG2337	Toxic component of a toxin-antitoxin (TA) module
Wei3612_RS08420	COG1696	Membrane protein involved in D-alanine export
Wei3612_RS08430	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
Wei3612_RS08450	COG3973	AAA domain
Wei3612_RS08465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Wei3612_RS08495	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Wei3612_RS08495	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Wei3612_RS08500	COG1268	BioY protein
Wei3612_RS08505	COG0194	GDP metabolic process
Wei3612_RS08520	COG1126	abc transporter atp-binding protein
Wei3612_RS08525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Wei3612_RS08530	COG0765	amino acid transport
Wei3612_RS08535	COG0765	amino acid transport
Wei3612_RS08540	COG4166	transmembrane transport
Wei3612_RS08545	COG0601	transmembrane transport
Wei3612_RS08550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Wei3612_RS08555	COG0444	Belongs to the ABC transporter superfamily
Wei3612_RS08560	COG4608	Belongs to the ABC transporter superfamily
Wei3612_RS08570	COG0359	binds to the 23S rRNA
Wei3612_RS08575	COG0305	Participates in initiation and elongation during chromosome replication
Wei3612_RS08580	COG2814	Major facilitator Superfamily
Wei3612_RS08590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Wei3612_RS08615	COG2832	Protein of unknown function (DUF454)
Wei3612_RS08620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Wei3612_RS08625	COG1744	ABC transporter substrate-binding protein PnrA-like
Wei3612_RS08630	COG1744	ABC transporter substrate-binding protein PnrA-like
Wei3612_RS08645	COG0492	ferredoxin-NADP+ reductase activity
Wei3612_RS08660	COG0588	phosphoglycerate mutase activity
Wei3612_RS08665	COG0386	Belongs to the glutathione peroxidase family
Wei3612_RS08685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Wei3612_RS08690	COG0628	permease
Wei3612_RS08695	COG0640	Transcriptional regulator
Wei3612_RS08705	COG0446	pyridine nucleotide-disulphide oxidoreductase
Wei3612_RS08720	COG2801	Transposase and inactivated derivatives
Wei3612_RS08725	COG1744	ABC transporter substrate-binding protein PnrA-like
Wei3612_RS08730	COG3845	ABC transporter
Wei3612_RS08735	COG4603	Belongs to the binding-protein-dependent transport system permease family
Wei3612_RS08740	COG1079	Belongs to the binding-protein-dependent transport system permease family
Wei3612_RS08745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Wei3612_RS08750	COG1077	Cell shape determining protein MreB Mrl
Wei3612_RS08760	COG0772	Belongs to the SEDS family
Wei3612_RS08765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Wei3612_RS08785	COG0561	phosphatase activity
Wei3612_RS08790	COG2169	Transcriptional regulator
Wei3612_RS08790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Wei3612_RS08795	COG0561	phosphatase activity
Wei3612_RS08805	COG0577	efflux transmembrane transporter activity
Wei3612_RS08805	COG1136	(ABC) transporter
Wei3612_RS08815	COG2188	Transcriptional regulator
Wei3612_RS08825	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Wei3612_RS08830	COG2814	Major facilitator Superfamily
Wei3612_RS08840	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
Wei3612_RS08845	COG0352	thiamine-phosphate diphosphorylase activity
Wei3612_RS08855	COG2252	PERMEase
Wei3612_RS08865	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Wei3612_RS08870	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Wei3612_RS08910	COG2826	transposase and inactivated derivatives, IS30 family
Wei3612_RS08930	COG4166	transmembrane transport
Wei3612_RS08935	COG1228	amidohydrolase
Wei3612_RS08955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Wei3612_RS08960	COG0656	L-ascorbic acid biosynthetic process
Wei3612_RS08965	COG1307	EDD domain protein, DegV family
Wei3612_RS08995	COG1435	thymidine kinase activity
Wei3612_RS09000	COG2076	Multidrug Resistance protein
Wei3612_RS09005	COG2076	Multidrug Resistance protein
Wei3612_RS09010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Wei3612_RS09010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Wei3612_RS09015	COG0307	riboflavin synthase, alpha
Wei3612_RS09025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Wei3612_RS09035	COG2801	Transposase and inactivated derivatives
Wei3612_RS09060	COG1174	glycine betaine transport
Wei3612_RS09070	COG1979	alcohol dehydrogenase
Wei3612_RS09075	COG1811	Na channel or pump
Wei3612_RS09100	COG2246	polysaccharide biosynthetic process
Wei3612_RS09105	COG0561	phosphatase activity
Wei3612_RS09110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Wei3612_RS09115	COG4589	Belongs to the CDS family
Wei3612_RS09120	COG0750	zinc metalloprotease
Wei3612_RS09125	COG0442	prolyl-tRNA aminoacylation
Wei3612_RS09130	COG2176	DNA-directed DNA polymerase activity
Wei3612_RS09210	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
Wei3612_RS09215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Wei3612_RS09220	COG2873	o-acetylhomoserine
Wei3612_RS09230	COG2183	response to ionizing radiation
Wei3612_RS09255	COG1940	carbohydrate kinase activity
Wei3612_RS09260	COG2723	6-phospho-beta-galactosidase activity
Wei3612_RS09265	COG3711	transcriptional antiterminator
Wei3612_RS09285	COG1309	transcriptional regulator
Wei3612_RS09305	COG2217	Heavy metal translocating P-type atpase
Wei3612_RS09310	COG2814	Major facilitator Superfamily
Wei3612_RS09350	COG0438	transferase activity, transferring glycosyl groups
Wei3612_RS09400	COG2217	Heavy metal translocating P-type atpase
Wei3612_RS09410	COG2235	arginine
Wei3612_RS09415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Wei3612_RS09440	COG3759	membrane
Wei3612_RS09445	COG1136	(ABC) transporter
Wei3612_RS09450	COG0577	efflux transmembrane transporter activity
Wei3612_RS09480	COG1609	Transcriptional regulator
Wei3612_RS09495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Wei3612_RS09510	COG1464	Belongs to the NlpA lipoprotein family
Wei3612_RS09525	COG0561	phosphatase activity
Wei3612_RS09540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Wei3612_RS09540	COG0302	gtp cyclohydrolase
Wei3612_RS09545	COG0302	gtp cyclohydrolase
Wei3612_RS09550	COG0285	dihydrofolate synthase activity
Wei3612_RS09560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Wei3612_RS09565	COG1116	anion transmembrane transporter activity
Wei3612_RS09575	COG0318	PFAM AMP-dependent synthetase and ligase
Wei3612_RS09585	COG2223	nitrite transmembrane transporter activity
Wei3612_RS09595	COG1609	Transcriptional regulator
Wei3612_RS09610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Wei3612_RS09625	COG1609	Transcriptional regulator
Wei3612_RS09630	COG1869	D-ribose catabolic process
Wei3612_RS09635	COG0738	Major facilitator superfamily
Wei3612_RS09680	COG2801	Transposase and inactivated derivatives
Wei3612_RS09760	COG0516	GMP reductase activity
Wei3612_RS09795	COG1126	abc transporter atp-binding protein
Wei3612_RS09805	COG0668	transmembrane transport
Wei3612_RS09825	COG0741	lytic transglycosylase activity
Wei3612_RS09830	COG0673	inositol 2-dehydrogenase activity
Wei3612_RS09835	COG0402	S-adenosylhomocysteine deaminase activity
Wei3612_RS09840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Wei3612_RS09845	COG0745	RESPONSE REGULATOR receiver
Wei3612_RS09850	COG3850	Histidine kinase
Wei3612_RS09850	COG5002	protein histidine kinase activity
Wei3612_RS09870	COG4975	Glucose uptake
Wei3612_RS09880	COG2017	converts alpha-aldose to the beta-anomer
Wei3612_RS09890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Wei3612_RS09895	COG1302	Protein conserved in bacteria
Wei3612_RS09910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Wei3612_RS09915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Wei3612_RS09920	COG1744	ABC transporter substrate-binding protein PnrA-like
Wei3612_RS09930	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Wei3612_RS09935	COG0626	cystathionine gamma-synthase activity
Wei3612_RS09940	COG0460	homoserine dehydrogenase
Wei3612_RS09950	COG0601	transmembrane transport
Wei3612_RS09955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Wei3612_RS09960	COG0444	Belongs to the ABC transporter superfamily
Wei3612_RS09965	COG4608	Belongs to the ABC transporter superfamily
Wei3612_RS09970	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Wei3612_RS09975	COG0049	tRNA binding
Wei3612_RS09980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Wei3612_RS09990	COG3842	ATPase activity
Wei3612_RS10000	COG1177	transmembrane transport
Wei3612_RS10010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Wei3612_RS10020	COG0589	response to stress
Wei3612_RS10030	COG1950	PFAM Membrane protein of
Wei3612_RS10035	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Wei3612_RS10040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Wei3612_RS10045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Wei3612_RS10075	COG0492	ferredoxin-NADP+ reductase activity
Wei3612_RS10080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Wei3612_RS10090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Wei3612_RS10095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Wei3612_RS10100	COG0149	triose-phosphate isomerase activity
Wei3612_RS10120	COG0154	amidase activity
Wei3612_RS10125	COG2814	Major facilitator Superfamily
Wei3612_RS10135	COG0557	exoribonuclease II activity
Wei3612_RS10150	COG2814	Major facilitator Superfamily
Wei3612_RS10155	COG0765	amino acid transport
Wei3612_RS10160	COG1126	abc transporter atp-binding protein
Wei3612_RS10165	COG2076	Multidrug Resistance protein
Wei3612_RS10170	COG2076	Multidrug Resistance protein
Wei3612_RS10180	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Wei3612_RS10185	COG0280	phosphate acetyltransferase
Wei3612_RS10190	COG0802	atpase or kinase
Wei3612_RS10200	COG2176	DNA-directed DNA polymerase activity
Wei3612_RS10205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Wei3612_RS10220	COG4856	YbbR-like protein
Wei3612_RS10225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Wei3612_RS10245	COG0540	Belongs to the ATCase OTCase family
Wei3612_RS10250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Wei3612_RS10255	COG0505	Belongs to the CarA family
Wei3612_RS10260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Wei3612_RS10265	COG0167	dihydroorotate dehydrogenase activity
Wei3612_RS10270	COG0284	orotidine-5'-phosphate decarboxylase activity
Wei3612_RS10275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Wei3612_RS10280	COG0438	transferase activity, transferring glycosyl groups
Wei3612_RS10285	COG0438	transferase activity, transferring glycosyl groups
Wei3612_RS10300	COG1368	sulfuric ester hydrolase activity
Wei3612_RS10355	COG1397	ADP-ribosylglycohydrolase
Wei3612_RS10380	COG3715	PTS system
Wei3612_RS10385	COG3716	PTS system mannose fructose sorbose family IID component
Wei3612_RS10395	COG0588	phosphoglycerate mutase activity
Wei3612_RS10445	COG0126	phosphoglycerate kinase activity
Wei3612_RS10450	COG0583	DNA-binding transcription factor activity
Wei3612_RS10460	COG0105	UTP biosynthetic process
Wei3612_RS10465	COG1454	alcohol dehydrogenase
Wei3612_RS10465	COG1012	belongs to the aldehyde dehydrogenase family
Wei3612_RS10475	COG0656	L-ascorbic acid biosynthetic process
Wei3612_RS10490	COG4974	Belongs to the 'phage' integrase family
Wei3612_RS10510	COG1396	sequence-specific DNA binding
Wei3612_RS10525	COG2801	Transposase and inactivated derivatives
Wei3612_RS10610	COG2801	Transposase and inactivated derivatives
Wei3612_RS10625	COG1113	amino acid transport
Wei3612_RS10630	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Wei3612_RS10635	COG1757	Na H antiporter
Wei3612_RS10640	COG0328	RNA-DNA hybrid ribonuclease activity
Wei3612_RS10650	COG0564	pseudouridine synthase activity
Wei3612_RS10660	COG0505	Belongs to the CarA family
Wei3612_RS10670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Wei3612_RS10675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Wei3612_RS10685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Wei3612_RS10690	COG1846	Transcriptional regulator
Wei3612_RS10695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Wei3612_RS10700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Wei3612_RS10705	COG2070	2-Nitropropane dioxygenase
Wei3612_RS10710	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Wei3612_RS10715	COG1028	Short-chain dehydrogenase reductase Sdr
Wei3612_RS10720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Wei3612_RS10735	COG0439	Biotin carboxylase
Wei3612_RS10740	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Wei3612_RS10750	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Wei3612_RS10765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Wei3612_RS10770	COG4115	mRNA cleavage
Wei3612_RS10780	COG1704	LemA family
Wei3612_RS10785	COG0501	Belongs to the peptidase M48B family
Wei3612_RS10795	COG2801	Transposase and inactivated derivatives
Wei3612_RS10805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Wei3612_RS10810	COG0673	inositol 2-dehydrogenase activity
Wei3612_RS10815	COG0513	Belongs to the DEAD box helicase family
Wei3612_RS10835	COG3764	Sortase (surface protein transpeptidase)
Wei3612_RS10840	COG1321	iron dependent repressor
Wei3612_RS10855	COG0083	homoserine kinase activity
Wei3612_RS10860	COG1609	Transcriptional regulator
Wei3612_RS10870	COG0527	aspartate kinase activity
Wei3612_RS10875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Wei3612_RS10880	COG0019	diaminopimelate decarboxylase activity
Wei3612_RS10885	COG2171	N-acyltransferase activity
Wei3612_RS10895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Wei3612_RS10900	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Wei3612_RS10905	COG0436	Aminotransferase
Wei3612_RS10910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Wei3612_RS10915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Wei3612_RS10930	COG0436	Aminotransferase
Wei3612_RS10935	COG4684	Psort location CytoplasmicMembrane, score
Wei3612_RS10950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Wei3612_RS10955	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Wei3612_RS10960	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Wei3612_RS10965	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Wei3612_RS10970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Wei3612_RS10975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Wei3612_RS10980	COG0710	3-dehydroquinate dehydratase activity
Wei3612_RS10995	COG1122	ATPase activity
Wei3612_RS11000	COG4721	ABC-type cobalt transport system, permease component
Wei3612_RS11005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Wei3612_RS11010	COG0667	Aldo Keto reductase
Wei3612_RS11030	COG1914	H( )-stimulated, divalent metal cation uptake system
Wei3612_RS11040	COG1695	Transcriptional regulator
Wei3612_RS11055	COG2936	dipeptidyl-peptidase activity
Wei3612_RS11065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Wei3612_RS11065	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Wei3612_RS11070	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Wei3612_RS11075	COG0154	amidase activity
Wei3612_RS11080	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Wei3612_RS11085	COG1597	lipid kinase activity
Wei3612_RS11095	COG0803	Belongs to the bacterial solute-binding protein 9 family
Wei3612_RS11105	COG1121	(ABC) transporter
Wei3612_RS11115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Wei3612_RS11130	COG0018	arginyl-trna synthetase
Wei3612_RS11150	COG1438	arginine binding
Wei3612_RS11155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Wei3612_RS11160	COG3679	Belongs to the UPF0342 family
Wei3612_RS11170	COG4717	serine-type aminopeptidase activity
Wei3612_RS11190	COG0028	Belongs to the TPP enzyme family
Wei3612_RS11205	COG0612	Peptidase, M16
Wei3612_RS11210	COG0612	Peptidase, M16
Wei3612_RS11215	COG1426	Protein conserved in bacteria
Wei3612_RS11220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Wei3612_RS11225	COG1546	Belongs to the CinA family
Wei3612_RS11225	COG1058	Belongs to the CinA family
Wei3612_RS11230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Wei3612_RS11240	COG3973	AAA domain
Wei3612_RS11245	COG2801	Transposase and inactivated derivatives
Wei3612_RS11250	COG1573	uracil-dna glycosylase
Wei3612_RS11260	COG1012	belongs to the aldehyde dehydrogenase family
Wei3612_RS11260	COG1454	alcohol dehydrogenase
Wei3612_RS11275	COG0640	Transcriptional regulator
Wei3612_RS11285	COG3118	belongs to the thioredoxin family
Wei3612_RS11290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Wei3612_RS11300	COG0492	ferredoxin-NADP+ reductase activity
Wei3612_RS11310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Wei3612_RS11330	COG2261	transglycosylase associated protein
Wei3612_RS11355	COG2801	Transposase and inactivated derivatives
Wei3612_RS11365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Wei3612_RS11370	COG0783	Belongs to the Dps family
Wei3612_RS11410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Wei3612_RS11415	COG2017	converts alpha-aldose to the beta-anomer
Wei3612_RS11440	COG5039	Polysaccharide pyruvyl transferase
Wei3612_RS11455	COG2801	Transposase and inactivated derivatives
Wei3612_RS11515	COG0489	protein tyrosine kinase activity
Wei3612_RS11520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Wei3612_RS11530	COG1316	TRANSCRIPTIONal
Wei3612_RS11535	COG4464	protein tyrosine phosphatase activity
Wei3612_RS11580	COG0438	transferase activity, transferring glycosyl groups
Wei3612_RS11640	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification