locus-tag	class	description
H3N00_RS00015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3N00_RS00020	COG0531	amino acid
H3N00_RS00035	COG1902	pentaerythritol trinitrate reductase activity
H3N00_RS00040	COG0626	cystathionine gamma-synthase activity
H3N00_RS00060	COG2244	polysaccharide biosynthetic process
H3N00_RS00070	COG0438	transferase activity, transferring glycosyl groups
H3N00_RS00075	COG0495	leucyl-tRNA aminoacylation
H3N00_RS00080	COG0671	phosphoesterase, PA-phosphatase related
H3N00_RS00090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H3N00_RS00115	COG2723	6-phospho-beta-galactosidase activity
H3N00_RS00135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H3N00_RS00145	COG0024	Methionine aminopeptidase
H3N00_RS00155	COG1316	TRANSCRIPTIONal
H3N00_RS00165	COG2205	protein histidine kinase activity
H3N00_RS00170	COG0745	RESPONSE REGULATOR receiver
H3N00_RS00175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H3N00_RS00190	COG2207	Transcriptional regulator
H3N00_RS00210	COG0308	aminopeptidase N
H3N00_RS00215	COG0833	amino acid
H3N00_RS00220	COG2040	homocysteine
H3N00_RS00225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3N00_RS00230	COG0542	response to heat
H3N00_RS00235	COG0308	aminopeptidase N
H3N00_RS00250	COG0395	ABC-type sugar transport system, permease component
H3N00_RS00255	COG1175	transmembrane transport
H3N00_RS00260	COG3842	ATPase activity
H3N00_RS00310	COG2814	Major facilitator Superfamily
H3N00_RS00335	COG1914	H( )-stimulated, divalent metal cation uptake system
H3N00_RS00405	COG0438	transferase activity, transferring glycosyl groups
H3N00_RS00435	COG2084	Dehydrogenase
H3N00_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
H3N00_RS00450	COG1620	l-lactate permease
H3N00_RS00455	COG4989	oxidoreductase activity
H3N00_RS00460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H3N00_RS00465	COG2233	PERMEase
H3N00_RS00480	COG1956	GAF domain-containing protein
H3N00_RS00495	COG1132	(ABC) transporter
H3N00_RS00500	COG1132	(ABC) transporter
H3N00_RS00505	COG0747	negative chemotaxis
H3N00_RS00510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3N00_RS00515	COG0601	transmembrane transport
H3N00_RS00520	COG4608	Belongs to the ABC transporter superfamily
H3N00_RS00525	COG0444	Belongs to the ABC transporter superfamily
H3N00_RS00530	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H3N00_RS00535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H3N00_RS00540	COG2211	Major facilitator Superfamily
H3N00_RS00540	COG2190	(PTS) system
H3N00_RS00555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H3N00_RS00560	COG0436	Aminotransferase
H3N00_RS00570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H3N00_RS00575	COG2723	6-phospho-beta-galactosidase activity
H3N00_RS00580	COG2723	6-phospho-beta-galactosidase activity
H3N00_RS00585	COG1447	Phosphotransferase system cellobiose-specific component IIA
H3N00_RS00590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H3N00_RS00595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H3N00_RS00610	COG1216	Glycosyl transferase, family 2
H3N00_RS00625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H3N00_RS00680	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H3N00_RS00685	COG1737	Transcriptional regulator
H3N00_RS00695	COG0656	L-ascorbic acid biosynthetic process
H3N00_RS00700	COG2261	transglycosylase associated protein
H3N00_RS00765	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H3N00_RS00770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H3N00_RS00785	COG0037	tRNA processing
H3N00_RS00795	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H3N00_RS00800	COG2244	polysaccharide biosynthetic process
H3N00_RS00805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H3N00_RS00810	COG0193	aminoacyl-tRNA hydrolase activity
H3N00_RS00820	COG0058	SHG alpha-glucan phosphorylase activity
H3N00_RS00825	COG0297	glycogen (starch) synthase activity
H3N00_RS00830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H3N00_RS00840	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H3N00_RS00850	COG1511	domain protein
H3N00_RS00850	COG1511	domain protein
H3N00_RS00855	COG1309	transcriptional regulator
H3N00_RS00870	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H3N00_RS00875	COG0477	Major facilitator Superfamily
H3N00_RS00885	COG0667	Aldo Keto reductase
H3N00_RS00895	COG2115	Belongs to the xylose isomerase family
H3N00_RS00905	COG2211	Major facilitator Superfamily
H3N00_RS00910	COG3507	Belongs to the glycosyl hydrolase 43 family
H3N00_RS00935	COG2818	Glycosylase
H3N00_RS00940	COG1968	undecaprenyl-diphosphatase activity
H3N00_RS00955	COG1695	Transcriptional regulator
H3N00_RS00960	COG1983	PspC domain protein
H3N00_RS00965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H3N00_RS00990	COG0737	Belongs to the 5'-nucleotidase family
H3N00_RS01005	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H3N00_RS01020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H3N00_RS01020	COG1263	PTS System
H3N00_RS01025	COG1316	TRANSCRIPTIONal
H3N00_RS01035	COG2131	deaminase
H3N00_RS01040	COG4466	Protein conserved in bacteria
H3N00_RS01045	COG1253	flavin adenine dinucleotide binding
H3N00_RS01050	COG1253	flavin adenine dinucleotide binding
H3N00_RS01055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H3N00_RS01060	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H3N00_RS01065	COG0084	hydrolase, TatD family'
H3N00_RS01075	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3N00_RS01075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3N00_RS01135	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H3N00_RS01155	COG1368	sulfuric ester hydrolase activity
H3N00_RS01160	COG2153	protein acetylation
H3N00_RS01175	COG0187	DNA topoisomerase II activity
H3N00_RS01180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H3N00_RS01185	COG2501	S4 domain
H3N00_RS01190	COG0592	DNA-directed DNA polymerase activity
H3N00_RS01195	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H3N00_RS01200	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H3N00_RS01205	COG0594	ribonuclease P activity
H3N00_RS01210	COG0706	membrane insertase activity
H3N00_RS01220	COG1120	ATPase activity
H3N00_RS01230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H3N00_RS01245	COG0569	domain protein
H3N00_RS01250	COG1113	amino acid transport
H3N00_RS01270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H3N00_RS01280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H3N00_RS01285	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3N00_RS01295	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H3N00_RS01300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H3N00_RS01310	COG1136	(ABC) transporter
H3N00_RS01315	COG0577	efflux transmembrane transporter activity
H3N00_RS01320	COG2409	Drug exporters of the RND superfamily
H3N00_RS01320	COG1033	growth of symbiont in host cell
H3N00_RS01325	COG0561	phosphatase activity
H3N00_RS01335	COG0328	RNA-DNA hybrid ribonuclease activity
H3N00_RS01355	COG3152	Membrane
H3N00_RS01360	COG2252	PERMEase
H3N00_RS01400	COG1881	PFAM PEBP family protein
H3N00_RS01415	COG2801	Transposase and inactivated derivatives
H3N00_RS01425	COG1476	TRANSCRIPTIONal
H3N00_RS01455	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H3N00_RS01455	COG0517	IMP dehydrogenase activity
H3N00_RS01460	COG2723	6-phospho-beta-galactosidase activity
H3N00_RS01490	COG0697	spore germination
H3N00_RS01505	COG0561	phosphatase activity
H3N00_RS01510	COG0561	phosphatase activity
H3N00_RS01520	COG1744	ABC transporter substrate-binding protein PnrA-like
H3N00_RS01525	COG0137	argininosuccinate synthase activity
H3N00_RS01530	COG0165	Argininosuccinate lyase
H3N00_RS01535	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H3N00_RS01540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H3N00_RS01545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H3N00_RS01550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H3N00_RS01555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H3N00_RS01560	COG0505	Belongs to the CarA family
H3N00_RS01565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H3N00_RS01585	COG1131	(ABC) transporter
H3N00_RS01595	COG0789	Transcriptional regulator
H3N00_RS01600	COG1028	Short-chain dehydrogenase reductase Sdr
H3N00_RS01610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H3N00_RS01620	COG0697	spore germination
H3N00_RS01645	COG1846	Transcriptional regulator
H3N00_RS01650	COG1132	(ABC) transporter
H3N00_RS01660	COG0656	L-ascorbic acid biosynthetic process
H3N00_RS01670	COG4619	ABC transporter
H3N00_RS01675	COG0390	transport system, permease component
H3N00_RS01685	COG1131	(ABC) transporter
H3N00_RS01695	COG1126	abc transporter atp-binding protein
H3N00_RS01700	COG0765	amino acid transport
H3N00_RS01705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3N00_RS01710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3N00_RS01715	COG1254	Belongs to the acylphosphatase family
H3N00_RS01725	COG0392	lysyltransferase activity
H3N00_RS01725	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H3N00_RS01735	COG0628	permease
H3N00_RS01765	COG1113	amino acid transport
H3N00_RS01790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H3N00_RS01795	COG0456	acetyltransferase
H3N00_RS01795	COG0454	-acetyltransferase
H3N00_RS01805	COG2855	membrane
H3N00_RS01815	COG2855	membrane
H3N00_RS01820	COG0583	DNA-binding transcription factor activity
H3N00_RS01830	COG2070	2-Nitropropane dioxygenase
H3N00_RS01850	COG0531	amino acid
H3N00_RS01860	COG3223	Belongs to the PsiE family
H3N00_RS01870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H3N00_RS01880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H3N00_RS01890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H3N00_RS01895	COG4166	transmembrane transport
H3N00_RS01900	COG2267	carboxylic ester hydrolase activity
H3N00_RS01910	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H3N00_RS01925	COG0477	Major facilitator Superfamily
H3N00_RS01930	COG4975	Glucose uptake
H3N00_RS01940	COG0531	amino acid
H3N00_RS01945	COG1113	amino acid transport
H3N00_RS01950	COG0531	amino acid
H3N00_RS01955	COG0252	asparaginase activity
H3N00_RS01960	COG4443	Transcriptional Coactivator p15 (PC4)
H3N00_RS01970	COG2226	methyltransferase
H3N00_RS01975	COG1335	isochorismatase
H3N00_RS01980	COG2050	protein possibly involved in aromatic compounds catabolism
H3N00_RS01985	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H3N00_RS01990	COG0318	PFAM AMP-dependent synthetase and ligase
H3N00_RS02005	COG0745	RESPONSE REGULATOR receiver
H3N00_RS02010	COG5002	protein histidine kinase activity
H3N00_RS02050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H3N00_RS02055	COG1194	a g-specific adenine glycosylase
H3N00_RS02065	COG0357	Ribosomal RNA small subunit methyltransferase G
H3N00_RS02070	COG1192	Involved in chromosome partitioning
H3N00_RS02075	COG1475	DNA binding
H3N00_RS02080	COG4481	Protein conserved in bacteria
H3N00_RS02085	COG0012	GTP binding
H3N00_RS02095	COG0745	RESPONSE REGULATOR receiver
H3N00_RS02105	COG1686	Belongs to the peptidase S11 family
H3N00_RS02110	COG2801	Transposase and inactivated derivatives
H3N00_RS02165	COG3104	oligopeptide transport
H3N00_RS02170	COG0477	Major facilitator Superfamily
H3N00_RS02175	COG4975	Glucose uptake
H3N00_RS02220	COG3091	SprT-like family
H3N00_RS02225	COG2755	lipolytic protein G-D-S-L family
H3N00_RS02225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H3N00_RS02230	COG1846	Transcriptional regulator
H3N00_RS02240	COG1121	(ABC) transporter
H3N00_RS02245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H3N00_RS02250	COG1373	ATPase (AAA superfamily
H3N00_RS02255	COG0488	(ABC) transporter
H3N00_RS02260	COG0534	Mate efflux family protein
H3N00_RS02275	COG3940	Belongs to the glycosyl hydrolase 43 family
H3N00_RS02295	COG2160	L-arabinose isomerase activity
H3N00_RS02300	COG0656	L-ascorbic acid biosynthetic process
H3N00_RS02325	COG0765	amino acid transport
H3N00_RS02365	COG1215	transferase activity, transferring glycosyl groups
H3N00_RS02370	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H3N00_RS02375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H3N00_RS02390	COG1418	mRNA catabolic process
H3N00_RS02395	COG2814	Major facilitator Superfamily
H3N00_RS02400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H3N00_RS02405	COG2188	Transcriptional regulator
H3N00_RS02410	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H3N00_RS02420	COG1216	Glycosyl transferase, family 2
H3N00_RS02445	COG5039	Polysaccharide pyruvyl transferase
H3N00_RS02495	COG3590	peptidase
H3N00_RS02505	COG1454	alcohol dehydrogenase
H3N00_RS02505	COG1012	belongs to the aldehyde dehydrogenase family
H3N00_RS02515	COG1373	ATPase (AAA superfamily
H3N00_RS02520	COG0708	Exodeoxyribonuclease III
H3N00_RS02540	COG0588	phosphoglycerate mutase activity
H3N00_RS02560	COG1132	(ABC) transporter
H3N00_RS02565	COG1132	(ABC) transporter
H3N00_RS02570	COG1373	ATPase (AAA superfamily
H3N00_RS02615	COG1482	cell wall glycoprotein biosynthetic process
H3N00_RS02620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H3N00_RS02625	COG3442	glutamine amidotransferase
H3N00_RS02635	COG1435	thymidine kinase activity
H3N00_RS02640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H3N00_RS02645	COG2890	protein-(glutamine-N5) methyltransferase activity
H3N00_RS02650	COG0009	L-threonylcarbamoyladenylate synthase
H3N00_RS02655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H3N00_RS02660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H3N00_RS02665	COG0702	epimerase
H3N00_RS02675	COG2233	PERMEase
H3N00_RS02680	COG0356	it plays a direct role in the translocation of protons across the membrane
H3N00_RS02685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H3N00_RS02690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H3N00_RS02695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H3N00_RS02700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H3N00_RS02705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H3N00_RS02710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H3N00_RS02715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H3N00_RS02720	COG1876	peptidase activity
H3N00_RS02725	COG1428	Deoxynucleoside kinase
H3N00_RS02730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H3N00_RS02755	COG4463	regulation of RNA biosynthetic process
H3N00_RS02760	COG0542	response to heat
H3N00_RS02765	COG0085	RNA polymerase activity
H3N00_RS02785	COG1979	alcohol dehydrogenase
H3N00_RS02810	COG1309	transcriptional regulator
H3N00_RS02815	COG0500	methyltransferase
H3N00_RS02860	COG3620	sequence-specific DNA binding
H3N00_RS02870	COG2807	transmembrane transport
H3N00_RS02880	COG2813	Specifically methylates the guanine in position
H3N00_RS02885	COG0590	tRNA wobble adenosine to inosine editing
H3N00_RS02895	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H3N00_RS02920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H3N00_RS02925	COG3870	Protein conserved in bacteria
H3N00_RS02945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H3N00_RS02950	COG1214	PFAM Peptidase M22, glycoprotease
H3N00_RS02955	COG0456	acetyltransferase
H3N00_RS02965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H3N00_RS02970	COG0142	geranyltranstransferase activity
H3N00_RS02975	COG0051	transcription antitermination factor activity, RNA binding
H3N00_RS02980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H3N00_RS02990	COG0089	rRNA binding
H3N00_RS02995	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H3N00_RS03000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H3N00_RS03005	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H3N00_RS03010	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H3N00_RS03015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H3N00_RS03020	COG0255	Belongs to the universal ribosomal protein uL29 family
H3N00_RS03030	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H3N00_RS03035	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H3N00_RS03040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H3N00_RS03045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H3N00_RS03050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H3N00_RS03055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H3N00_RS03060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H3N00_RS03065	COG1841	ribosomal large subunit assembly
H3N00_RS03070	COG0200	Binds to the 23S rRNA
H3N00_RS03085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H3N00_RS03090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H3N00_RS03095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H3N00_RS03100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H3N00_RS03105	COG0202	RNA polymerase activity
H3N00_RS03110	COG0203	ribosomal protein L17
H3N00_RS03135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H3N00_RS03150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H3N00_RS03175	COG0583	DNA-binding transcription factor activity
H3N00_RS03185	COG1053	succinate dehydrogenase
H3N00_RS03190	COG0471	metal ion transport
H3N00_RS03195	COG0039	L-malate dehydrogenase activity
H3N00_RS03200	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H3N00_RS03205	COG0215	cysteine-tRNA ligase activity
H3N00_RS03210	COG0626	cystathionine gamma-synthase activity
H3N00_RS03215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H3N00_RS03220	COG1464	Belongs to the NlpA lipoprotein family
H3N00_RS03225	COG1854	S-ribosylhomocysteine lyase activity
H3N00_RS03230	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H3N00_RS03235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H3N00_RS03250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H3N00_RS03255	COG0250	Participates in transcription elongation, termination and antitermination
H3N00_RS03260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H3N00_RS03265	COG0081	regulation of translation
H3N00_RS03270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H3N00_RS03275	COG0222	ribosome binding
H3N00_RS03295	COG2801	Transposase and inactivated derivatives
H3N00_RS03300	COG1121	(ABC) transporter
H3N00_RS03305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H3N00_RS03310	COG0803	Belongs to the bacterial solute-binding protein 9 family
H3N00_RS03315	COG1252	NADH dehydrogenase
H3N00_RS03325	COG1122	ATPase activity
H3N00_RS03330	COG1122	ATPase activity
H3N00_RS03340	COG0101	tRNA pseudouridine synthase activity
H3N00_RS03345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H3N00_RS03370	COG0028	Belongs to the TPP enzyme family
H3N00_RS03385	COG1573	uracil-dna glycosylase
H3N00_RS03400	COG0366	Alpha amylase catalytic
H3N00_RS03410	COG0671	phosphoesterase, PA-phosphatase related
H3N00_RS03430	COG2814	Major facilitator Superfamily
H3N00_RS03435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H3N00_RS03450	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H3N00_RS03455	COG1481	regulation of sporulation
H3N00_RS03460	COG0740	serine-type endopeptidase activity
H3N00_RS03475	COG1263	PTS System
H3N00_RS03475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H3N00_RS03485	COG1914	H( )-stimulated, divalent metal cation uptake system
H3N00_RS03505	COG0039	L-malate dehydrogenase activity
H3N00_RS03510	COG0028	Belongs to the TPP enzyme family
H3N00_RS03515	COG3527	Alpha-acetolactate decarboxylase
H3N00_RS03525	COG1388	LysM domain
H3N00_RS03525	COG3942	CHAP domain
H3N00_RS03530	COG0791	NLP P60 protein
H3N00_RS03540	COG0756	dUTP diphosphatase activity
H3N00_RS03550	COG4956	integral membrane protein (PIN domain superfamily)
H3N00_RS03560	COG0653	protein targeting
H3N00_RS03565	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H3N00_RS03580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H3N00_RS03590	COG1733	regulation of RNA biosynthetic process
H3N00_RS03595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H3N00_RS03600	COG0072	phenylalanine-tRNA ligase activity
H3N00_RS03600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3N00_RS03605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H3N00_RS03610	COG0514	ATP-dependent DNA helicase (RecQ)
H3N00_RS03615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H3N00_RS03625	COG0768	penicillin binding
H3N00_RS03630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H3N00_RS03645	COG1940	carbohydrate kinase activity
H3N00_RS03660	COG3942	CHAP domain
H3N00_RS03680	COG0584	glycerophosphoryl diester phosphodiesterase
H3N00_RS03690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H3N00_RS03695	COG0789	Transcriptional regulator
H3N00_RS03700	COG0174	glutamine synthetase
H3N00_RS03725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H3N00_RS03730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H3N00_RS03735	COG1472	Belongs to the glycosyl hydrolase 3 family
H3N00_RS03765	COG0778	Nitroreductase
H3N00_RS03770	COG1169	isochorismate synthase
H3N00_RS03775	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H3N00_RS03780	COG0596	Alpha beta hydrolase
H3N00_RS03785	COG4948	Mandelate Racemase Muconate Lactonizing
H3N00_RS03815	COG0737	Belongs to the 5'-nucleotidase family
H3N00_RS03820	COG4470	Protein conserved in bacteria
H3N00_RS03825	COG0647	UMP catabolic process
H3N00_RS03830	COG4166	transmembrane transport
H3N00_RS03835	COG0673	inositol 2-dehydrogenase activity
H3N00_RS03870	COG0573	inorganic phosphate transmembrane transporter activity
H3N00_RS03875	COG0581	inorganic phosphate transmembrane transporter activity
H3N00_RS03880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H3N00_RS03885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H3N00_RS03890	COG0704	Plays a role in the regulation of phosphate uptake
H3N00_RS03895	COG2137	regulation of response to DNA damage stimulus
H3N00_RS03925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H3N00_RS03935	COG5506	Protein of unknown function (DUF1694)
H3N00_RS03945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H3N00_RS04065	COG1272	protein, Hemolysin III
H3N00_RS04095	COG0525	valine-tRNA ligase activity
H3N00_RS04105	COG0285	dihydrofolate synthase activity
H3N00_RS04135	COG0488	(ABC) transporter
H3N00_RS04140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H3N00_RS04145	COG0459	protein refolding
H3N00_RS04150	COG0531	amino acid
H3N00_RS04160	COG1181	Belongs to the D-alanine--D-alanine ligase family
H3N00_RS04165	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H3N00_RS04170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H3N00_RS04180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H3N00_RS04185	COG1713	HD superfamily hydrolase involved in NAD metabolism
H3N00_RS04190	COG0799	negative regulation of ribosome biogenesis
H3N00_RS04195	COG2226	methyltransferase
H3N00_RS04200	COG1323	Belongs to the UPF0348 family
H3N00_RS04210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H3N00_RS04215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H3N00_RS04315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H3N00_RS04320	COG3764	Sortase (surface protein transpeptidase)
H3N00_RS04325	COG0363	glucosamine-6-phosphate deaminase activity
H3N00_RS04330	COG0776	regulation of translation
H3N00_RS04340	COG0577	efflux transmembrane transporter activity
H3N00_RS04345	COG1136	(ABC) transporter
H3N00_RS04360	COG4720	Psort location CytoplasmicMembrane, score
H3N00_RS04365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H3N00_RS04370	COG1570	exodeoxyribonuclease VII activity
H3N00_RS04380	COG0142	geranyltranstransferase activity
H3N00_RS04385	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H3N00_RS04390	COG1438	arginine binding
H3N00_RS04395	COG0497	DNA recombination
H3N00_RS04405	COG0194	GDP metabolic process
H3N00_RS04415	COG0586	Pfam SNARE associated Golgi protein
H3N00_RS04420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H3N00_RS04425	COG1098	S1 RNA binding domain
H3N00_RS04540	COG4684	Psort location CytoplasmicMembrane, score
H3N00_RS04545	COG1271	oxidase subunit
H3N00_RS04550	COG1294	oxidase, subunit
H3N00_RS04555	COG4988	ABC transporter
H3N00_RS04560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H3N00_RS04565	COG1705	Flagellar rod assembly protein muramidase FlgJ
H3N00_RS04565	COG1388	LysM domain
H3N00_RS04570	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H3N00_RS04585	COG1278	Cold shock
H3N00_RS04590	COG0494	nUDIX hydrolase
H3N00_RS04600	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H3N00_RS04605	COG0346	lactoylglutathione lyase activity
H3N00_RS04610	COG0400	carboxylic ester hydrolase activity
H3N00_RS04630	COG0741	lytic transglycosylase activity
H3N00_RS04650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H3N00_RS04655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H3N00_RS04660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H3N00_RS04670	COG4120	Belongs to the binding-protein-dependent transport system permease family
H3N00_RS04680	COG0038	chloride channel
H3N00_RS04685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H3N00_RS04690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H3N00_RS04695	COG1307	EDD domain protein, DegV family
H3N00_RS04700	COG2190	(PTS) system
H3N00_RS04700	COG1263	PTS System
H3N00_RS04700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H3N00_RS04715	COG2003	Belongs to the UPF0758 family
H3N00_RS04720	COG1077	Cell shape determining protein MreB Mrl
H3N00_RS04730	COG3338	carbonate dehydratase activity
H3N00_RS04740	COG0765	amino acid transport
H3N00_RS04745	COG1126	abc transporter atp-binding protein
H3N00_RS04755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3N00_RS04755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3N00_RS04760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H3N00_RS04765	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H3N00_RS04770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H3N00_RS04775	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H3N00_RS04780	COG0047	phosphoribosylformylglycinamidine synthase activity
H3N00_RS04785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H3N00_RS04795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H3N00_RS04800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H3N00_RS04805	COG0138	bifunctional purine biosynthesis protein purh
H3N00_RS04810	COG0151	Belongs to the GarS family
H3N00_RS04815	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H3N00_RS04835	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3N00_RS04855	COG0833	amino acid
H3N00_RS04865	COG2264	protein methyltransferase activity
H3N00_RS04870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H3N00_RS04880	COG2001	Belongs to the MraZ family
H3N00_RS04885	COG0275	rRNA processing
H3N00_RS04900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H3N00_RS04905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H3N00_RS04910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H3N00_RS04915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H3N00_RS04920	COG0849	cell division
H3N00_RS04930	COG1799	cell septum assembly
H3N00_RS04945	COG3599	regulation of cell shape
H3N00_RS04965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H3N00_RS04970	COG0217	transcriptional regulatory protein
H3N00_RS04975	COG2252	PERMEase
H3N00_RS04980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H3N00_RS05020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H3N00_RS05025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H3N00_RS05030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H3N00_RS05035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H3N00_RS05035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H3N00_RS05040	COG0631	protein serine/threonine phosphatase activity
H3N00_RS05045	COG0515	serine threonine protein kinase
H3N00_RS05045	COG2815	serine threonine protein kinase
H3N00_RS05050	COG1162	GTPase activity
H3N00_RS05055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H3N00_RS05065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H3N00_RS05075	COG1461	Dihydroxyacetone kinase
H3N00_RS05085	COG0438	transferase activity, transferring glycosyl groups
H3N00_RS05095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H3N00_RS05100	COG0416	fatty acid biosynthetic process
H3N00_RS05105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3N00_RS05110	COG0571	ribonuclease III activity
H3N00_RS05115	COG1196	nuclear chromosome segregation
H3N00_RS05120	COG0552	protein localization to endoplasmic reticulum
H3N00_RS05125	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H3N00_RS05130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H3N00_RS05150	COG0228	four-way junction DNA binding
H3N00_RS05155	COG0582	viral genome integration into host DNA
H3N00_RS05265	COG0588	phosphoglycerate mutase activity
H3N00_RS05270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H3N00_RS05275	COG0336	Belongs to the RNA methyltransferase TrmD family
H3N00_RS05280	COG0335	large ribosomal subunit rRNA binding
H3N00_RS05290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H3N00_RS05295	COG1942	4-Oxalocrotonate Tautomerase
H3N00_RS05300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H3N00_RS05310	COG1428	Deoxynucleoside kinase
H3N00_RS05315	COG1970	mechanosensitive ion channel activity
H3N00_RS05320	COG0561	phosphatase activity
H3N00_RS05385	COG3853	Toxic anion resistance protein (TelA)
H3N00_RS05390	COG1393	Belongs to the ArsC family
H3N00_RS05395	COG4862	establishment of competence for transformation
H3N00_RS05400	COG2723	6-phospho-beta-galactosidase activity
H3N00_RS05405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H3N00_RS05410	COG1447	Phosphotransferase system cellobiose-specific component IIA
H3N00_RS05415	COG2723	6-phospho-beta-galactosidase activity
H3N00_RS05420	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H3N00_RS05430	COG1164	Oligoendopeptidase f
H3N00_RS05435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H3N00_RS05450	COG1609	Transcriptional regulator
H3N00_RS05455	COG0006	proline dipeptidase activity
H3N00_RS05530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H3N00_RS05535	COG3425	synthase
H3N00_RS05550	COG0860	N-Acetylmuramoyl-L-alanine amidase
H3N00_RS05555	COG0124	histidyl-tRNA synthetase
H3N00_RS05560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H3N00_RS05575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H3N00_RS05580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H3N00_RS05585	COG1610	YqeY-like protein
H3N00_RS05590	COG1702	phosphate starvation-inducible protein PhoH
H3N00_RS05595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H3N00_RS05600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H3N00_RS05605	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H3N00_RS05610	COG1381	Involved in DNA repair and RecF pathway recombination
H3N00_RS05625	COG0752	glycyl-tRNA synthetase alpha subunit
H3N00_RS05630	COG0751	glycine-tRNA ligase activity
H3N00_RS05650	COG2706	6-phosphogluconolactonase activity
H3N00_RS05655	COG0628	permease
H3N00_RS05665	COG1674	ftsk spoiiie
H3N00_RS05675	COG4152	abc transporter atp-binding protein
H3N00_RS05680	COG1668	transmembrane transport
H3N00_RS05690	COG0322	excinuclease ABC activity
H3N00_RS05700	COG1739	Uncharacterized protein family UPF0029
H3N00_RS05715	COG0517	IMP dehydrogenase activity
H3N00_RS05715	COG0516	GMP reductase activity
H3N00_RS05720	COG0517	IMP dehydrogenase activity
H3N00_RS05720	COG0516	GMP reductase activity
H3N00_RS05725	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H3N00_RS05730	COG0632	four-way junction helicase activity
H3N00_RS05735	COG2255	four-way junction helicase activity
H3N00_RS05740	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H3N00_RS05775	COG0343	queuine tRNA-ribosyltransferase activity
H3N00_RS05780	COG1862	Preprotein translocase
H3N00_RS05785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H3N00_RS05790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H3N00_RS05795	COG0513	Belongs to the DEAD box helicase family
H3N00_RS05800	COG1929	Belongs to the glycerate kinase type-1 family
H3N00_RS05805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H3N00_RS05825	COG3906	Belongs to the UPF0473 family
H3N00_RS05835	COG2333	competence protein COMEC
H3N00_RS05835	COG0658	competence protein
H3N00_RS05840	COG1466	dna polymerase III delta subunit
H3N00_RS05845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H3N00_RS05850	COG0268	Binds directly to 16S ribosomal RNA
H3N00_RS05875	COG0544	peptidyl-prolyl cis-trans isomerase activity
H3N00_RS05880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H3N00_RS05885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H3N00_RS05905	COG1193	negative regulation of DNA recombination
H3N00_RS05930	COG3118	belongs to the thioredoxin family
H3N00_RS05935	COG0187	DNA topoisomerase II activity
H3N00_RS05940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H3N00_RS05945	COG3527	Alpha-acetolactate decarboxylase
H3N00_RS05950	COG1473	amidohydrolase
H3N00_RS05965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H3N00_RS05990	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H3N00_RS05995	COG3201	nicotinamide mononucleotide transporter
H3N00_RS06030	COG0028	Belongs to the TPP enzyme family
H3N00_RS06035	COG2801	Transposase and inactivated derivatives
H3N00_RS06085	COG0277	FAD linked oxidase domain protein
H3N00_RS06090	COG0436	Aminotransferase
H3N00_RS06105	COG1464	Belongs to the NlpA lipoprotein family
H3N00_RS06120	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H3N00_RS06125	COG0351	phosphomethylpyrimidine kinase
H3N00_RS06130	COG0352	thiamine-phosphate diphosphorylase activity
H3N00_RS06150	COG1028	Short-chain dehydrogenase reductase Sdr
H3N00_RS06160	COG1940	carbohydrate kinase activity
H3N00_RS06240	COG0546	phosphoglycolate phosphatase activity
H3N00_RS06245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H3N00_RS06250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H3N00_RS06260	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
H3N00_RS06285	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
H3N00_RS06290	COG1518	maintenance of DNA repeat elements
H3N00_RS06295	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H3N00_RS06310	COG2357	RelA SpoT domain protein
H3N00_RS06315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H3N00_RS06320	COG0564	pseudouridine synthase activity
H3N00_RS06325	COG2239	Acts as a magnesium transporter
H3N00_RS06335	COG0456	acetyltransferase
H3N00_RS06385	COG2801	Transposase and inactivated derivatives
H3N00_RS06400	COG4753	response regulator
H3N00_RS06400	COG2207	Transcriptional regulator
H3N00_RS06410	COG0384	phenazine biosynthesis protein PhzF
H3N00_RS06420	COG1621	beta-fructofuranosidase activity
H3N00_RS06440	COG1033	growth of symbiont in host cell
H3N00_RS06440	COG2409	Drug exporters of the RND superfamily
H3N00_RS06455	COG4684	Psort location CytoplasmicMembrane, score
H3N00_RS06470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H3N00_RS06475	COG0738	Major facilitator superfamily
H3N00_RS06480	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H3N00_RS06510	COG1304	FMN binding
H3N00_RS06525	COG0779	Required for maturation of 30S ribosomal subunits
H3N00_RS06530	COG0195	Participates in both transcription termination and antitermination
H3N00_RS06535	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H3N00_RS06545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H3N00_RS06550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H3N00_RS06555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H3N00_RS06570	COG0196	riboflavin kinase activity
H3N00_RS06575	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H3N00_RS06580	COG3142	Participates in the control of copper homeostasis
H3N00_RS06595	COG2270	Major facilitator Superfamily
H3N00_RS06600	COG1307	EDD domain protein, DegV family
H3N00_RS06605	COG1307	EDD domain protein, DegV family
H3N00_RS06610	COG2755	lipolytic protein G-D-S-L family
H3N00_RS06620	COG4479	Belongs to the UPF0346 family
H3N00_RS06630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H3N00_RS06640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H3N00_RS06645	COG4974	Belongs to the 'phage' integrase family
H3N00_RS06655	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H3N00_RS06675	COG3448	diguanylate cyclase activity
H3N00_RS06675	COG4175	Glycine betaine
H3N00_RS06690	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3N00_RS06695	COG1464	Belongs to the NlpA lipoprotein family
H3N00_RS06700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H3N00_RS06705	COG1597	lipid kinase activity
H3N00_RS06710	COG1011	Hydrolase
H3N00_RS06745	COG0242	peptide deformylase activity
H3N00_RS06750	COG4476	Belongs to the UPF0223 family
H3N00_RS06755	COG0483	inositol monophosphate 1-phosphatase activity
H3N00_RS06765	COG0772	Belongs to the SEDS family
H3N00_RS06770	COG4471	UPF0298 protein
H3N00_RS06775	COG0742	ribosomal rna small subunit methyltransferase
H3N00_RS06780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H3N00_RS06785	COG3480	Lon protease (S16) C-terminal proteolytic domain
H3N00_RS06790	COG0477	Major facilitator Superfamily
H3N00_RS06800	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H3N00_RS06805	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H3N00_RS06810	COG0358	DNA primase activity
H3N00_RS06815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H3N00_RS06845	COG0745	RESPONSE REGULATOR receiver
H3N00_RS06850	COG5002	protein histidine kinase activity
H3N00_RS06855	COG0572	uridine kinase
H3N00_RS06860	COG1363	Peptidase, m42
H3N00_RS06865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H3N00_RS06875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H3N00_RS06880	COG0670	Belongs to the BI1 family
H3N00_RS06885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H3N00_RS06885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H3N00_RS06890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H3N00_RS06895	COG0237	dephospho-CoA kinase activity
H3N00_RS06905	COG1484	DNA-dependent DNA replication
H3N00_RS06920	COG0745	RESPONSE REGULATOR receiver
H3N00_RS06925	COG5002	protein histidine kinase activity
H3N00_RS06935	COG3942	CHAP domain
H3N00_RS06935	COG1705	Flagellar rod assembly protein muramidase FlgJ
H3N00_RS06940	COG2801	Transposase and inactivated derivatives
H3N00_RS06975	COG0706	membrane insertase activity
H3N00_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
H3N00_RS06985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H3N00_RS06995	COG1304	FMN binding
H3N00_RS07015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H3N00_RS07015	COG1199	ATP-dependent helicase activity
H3N00_RS07025	COG0017	Asparaginyl-tRNA synthetase
H3N00_RS07030	COG3935	DnaD domain protein
H3N00_RS07040	COG3331	DNA recombination
H3N00_RS07045	COG4474	Belongs to the UPF0398 family
H3N00_RS07050	COG3599	regulation of cell shape
H3N00_RS07060	COG0116	Belongs to the methyltransferase superfamily
H3N00_RS07070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H3N00_RS07090	COG0556	nucleotide-excision repair
H3N00_RS07100	COG0439	Biotin carboxylase
H3N00_RS07105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H3N00_RS07115	COG3104	oligopeptide transport
H3N00_RS07120	COG0363	glucosamine-6-phosphate deaminase activity
H3N00_RS07130	COG0537	adenosine 5'-monophosphoramidase activity
H3N00_RS07135	COG1131	(ABC) transporter
H3N00_RS07145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H3N00_RS07150	COG1719	4-vinyl reductase, 4VR
H3N00_RS07155	COG1397	ADP-ribosylglycohydrolase
H3N00_RS07200	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3N00_RS07205	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
H3N00_RS07210	COG1349	DNA-binding transcription factor activity
H3N00_RS07215	COG1105	Belongs to the carbohydrate kinase PfkB family
H3N00_RS07220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H3N00_RS07220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H3N00_RS07220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H3N00_RS07230	COG1609	Transcriptional regulator
H3N00_RS07240	COG0306	phosphate transporter
H3N00_RS07255	COG2723	6-phospho-beta-galactosidase activity
H3N00_RS07275	COG0531	amino acid
H3N00_RS07285	COG0481	GTPase activity
H3N00_RS07320	COG1028	Short-chain dehydrogenase reductase Sdr
H3N00_RS07325	COG4708	membrane
H3N00_RS07335	COG0531	amino acid
H3N00_RS07340	COG4221	oxidoreductase activity
H3N00_RS07360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H3N00_RS07375	COG1136	(ABC) transporter
H3N00_RS07380	COG0577	efflux transmembrane transporter activity
H3N00_RS07405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H3N00_RS07415	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H3N00_RS07420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H3N00_RS07430	COG2801	Transposase and inactivated derivatives
H3N00_RS07460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H3N00_RS07465	COG2384	SAM-dependent methyltransferase
H3N00_RS07470	COG0071	Belongs to the small heat shock protein (HSP20) family
H3N00_RS07475	COG0457	Tetratricopeptide repeat
H3N00_RS07520	COG0419	ATPase involved in DNA repair
H3N00_RS07525	COG0420	3'-5' exonuclease activity
H3N00_RS07535	COG2807	transmembrane transport
H3N00_RS07540	COG4720	Psort location CytoplasmicMembrane, score
H3N00_RS07545	COG0351	phosphomethylpyrimidine kinase
H3N00_RS07555	COG1160	GTP binding
H3N00_RS07560	COG0539	negative regulation of cytoplasmic translation
H3N00_RS07565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H3N00_RS07575	COG0514	ATP-dependent DNA helicase (RecQ)
H3N00_RS07585	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H3N00_RS07600	COG1187	pseudouridine synthase activity
H3N00_RS07605	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H3N00_RS07610	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H3N00_RS07625	COG2996	Protein conserved in bacteria
H3N00_RS07635	COG0475	glutathione-regulated potassium exporter activity
H3N00_RS07645	COG1490	D-aminoacyl-tRNA deacylase activity
H3N00_RS07650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H3N00_RS07655	COG0587	DNA-directed DNA polymerase activity
H3N00_RS07665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H3N00_RS07670	COG0488	(ABC) transporter
H3N00_RS07675	COG0617	tRNA 3'-terminal CCA addition
H3N00_RS07680	COG1136	(ABC) transporter
H3N00_RS07695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H3N00_RS07700	COG0004	ammonium transporteR
H3N00_RS07710	COG0366	Alpha amylase catalytic
H3N00_RS07710	COG5263	repeat protein
H3N00_RS07715	COG1316	TRANSCRIPTIONal
H3N00_RS07720	COG1216	Glycosyl transferase, family 2
H3N00_RS07735	COG1442	glycosyl transferase family 8
H3N00_RS07735	COG1216	Glycosyl transferase, family 2
H3N00_RS07745	COG0438	transferase activity, transferring glycosyl groups
H3N00_RS07750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H3N00_RS07755	COG0489	protein tyrosine kinase activity
H3N00_RS07770	COG0233	cytoplasmic translational termination
H3N00_RS07775	COG0528	UMP kinase activity
H3N00_RS07780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H3N00_RS07785	COG0052	Belongs to the universal ribosomal protein uS2 family
H3N00_RS07790	COG2827	Endonuclease containing a URI domain
H3N00_RS07795	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H3N00_RS07800	COG0204	Acyl-transferase
H3N00_RS07825	COG3763	UPF0154 protein
H3N00_RS07830	COG4224	UPF0291 protein
H3N00_RS07835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H3N00_RS07855	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H3N00_RS07855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H3N00_RS07860	COG1234	tRNA 3'-trailer cleavage
H3N00_RS07875	COG0484	heat shock protein binding
H3N00_RS07880	COG0443	Heat shock 70 kDa protein
H3N00_RS07890	COG1420	regulation of RNA biosynthetic process
H3N00_RS07920	COG1216	Glycosyl transferase, family 2
H3N00_RS07930	COG0463	Glycosyl transferase, family 2
H3N00_RS07940	COG1705	Flagellar rod assembly protein muramidase FlgJ
H3N00_RS07955	COG0562	UDP-galactopyranose mutase
H3N00_RS07980	COG0024	Methionine aminopeptidase
H3N00_RS08000	COG1388	LysM domain
H3N00_RS08000	COG1705	Flagellar rod assembly protein muramidase FlgJ
H3N00_RS08015	COG2801	Transposase and inactivated derivatives
H3N00_RS08045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H3N00_RS08055	COG1682	transport, permease protein
H3N00_RS08060	COG1134	teichoic acid transport
H3N00_RS08060	COG1388	LysM domain
H3N00_RS08070	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H3N00_RS08075	COG3475	LICD family
H3N00_RS08085	COG0463	Glycosyl transferase, family 2
H3N00_RS08090	COG2246	polysaccharide biosynthetic process
H3N00_RS08100	COG1216	Glycosyl transferase, family 2
H3N00_RS08105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H3N00_RS08125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H3N00_RS08165	COG2801	Transposase and inactivated derivatives
H3N00_RS08210	COG2309	aminopeptidase activity
H3N00_RS08225	COG0564	pseudouridine synthase activity
H3N00_RS08230	COG1278	Cold shock
H3N00_RS08240	COG2814	Major facilitator Superfamily
H3N00_RS08245	COG0741	lytic transglycosylase activity
H3N00_RS08255	COG3973	AAA domain
H3N00_RS08265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H3N00_RS08270	COG1546	Belongs to the CinA family
H3N00_RS08270	COG1058	Belongs to the CinA family
H3N00_RS08275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H3N00_RS08280	COG1426	Protein conserved in bacteria
H3N00_RS08285	COG0612	Peptidase, M16
H3N00_RS08290	COG0612	Peptidase, M16
H3N00_RS08305	COG0028	Belongs to the TPP enzyme family
H3N00_RS08325	COG4717	serine-type aminopeptidase activity
H3N00_RS08335	COG3679	Belongs to the UPF0342 family
H3N00_RS08340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H3N00_RS08345	COG1438	arginine binding
H3N00_RS08365	COG0018	arginyl-trna synthetase
H3N00_RS08380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H3N00_RS08390	COG1121	(ABC) transporter
H3N00_RS08400	COG0803	Belongs to the bacterial solute-binding protein 9 family
H3N00_RS08410	COG1597	lipid kinase activity
H3N00_RS08415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H3N00_RS08420	COG0154	amidase activity
H3N00_RS08425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H3N00_RS08430	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H3N00_RS08430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H3N00_RS08440	COG2936	dipeptidyl-peptidase activity
H3N00_RS08455	COG1695	Transcriptional regulator
H3N00_RS08465	COG1914	H( )-stimulated, divalent metal cation uptake system
H3N00_RS08485	COG0667	Aldo Keto reductase
H3N00_RS08490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H3N00_RS08495	COG4721	ABC-type cobalt transport system, permease component
H3N00_RS08500	COG1122	ATPase activity
H3N00_RS08515	COG0710	3-dehydroquinate dehydratase activity
H3N00_RS08520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H3N00_RS08525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H3N00_RS08530	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H3N00_RS08535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H3N00_RS08540	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H3N00_RS08545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H3N00_RS08560	COG4684	Psort location CytoplasmicMembrane, score
H3N00_RS08565	COG0436	Aminotransferase
H3N00_RS08580	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H3N00_RS08585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H3N00_RS08590	COG0436	Aminotransferase
H3N00_RS08595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H3N00_RS08600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H3N00_RS08610	COG2171	N-acyltransferase activity
H3N00_RS08615	COG0019	diaminopimelate decarboxylase activity
H3N00_RS08620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H3N00_RS08625	COG0527	aspartate kinase activity
H3N00_RS08635	COG1609	Transcriptional regulator
H3N00_RS08640	COG0083	homoserine kinase activity
H3N00_RS08655	COG1321	iron dependent repressor
H3N00_RS08660	COG3764	Sortase (surface protein transpeptidase)
H3N00_RS08680	COG0513	Belongs to the DEAD box helicase family
H3N00_RS08685	COG0673	inositol 2-dehydrogenase activity
H3N00_RS08690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H3N00_RS08715	COG0501	Belongs to the peptidase M48B family
H3N00_RS08720	COG1704	LemA family
H3N00_RS08730	COG4115	mRNA cleavage
H3N00_RS08735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H3N00_RS08750	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H3N00_RS08760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H3N00_RS08765	COG0439	Biotin carboxylase
H3N00_RS08780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H3N00_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
H3N00_RS08790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H3N00_RS08795	COG2070	2-Nitropropane dioxygenase
H3N00_RS08800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H3N00_RS08805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3N00_RS08810	COG1846	Transcriptional regulator
H3N00_RS08815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H3N00_RS08825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H3N00_RS08830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H3N00_RS08840	COG0505	Belongs to the CarA family
H3N00_RS08850	COG0564	pseudouridine synthase activity
H3N00_RS08860	COG0328	RNA-DNA hybrid ribonuclease activity
H3N00_RS08870	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H3N00_RS08875	COG1113	amino acid transport
H3N00_RS08890	COG2801	Transposase and inactivated derivatives
H3N00_RS08990	COG2801	Transposase and inactivated derivatives
H3N00_RS09005	COG1396	sequence-specific DNA binding
H3N00_RS09025	COG4974	Belongs to the 'phage' integrase family
H3N00_RS09040	COG0656	L-ascorbic acid biosynthetic process
H3N00_RS09050	COG1012	belongs to the aldehyde dehydrogenase family
H3N00_RS09050	COG1454	alcohol dehydrogenase
H3N00_RS09055	COG0105	UTP biosynthetic process
H3N00_RS09065	COG0583	DNA-binding transcription factor activity
H3N00_RS09070	COG0126	phosphoglycerate kinase activity
H3N00_RS09120	COG0588	phosphoglycerate mutase activity
H3N00_RS09130	COG3716	PTS system mannose fructose sorbose family IID component
H3N00_RS09135	COG3715	PTS system
H3N00_RS09165	COG1397	ADP-ribosylglycohydrolase
H3N00_RS09225	COG1368	sulfuric ester hydrolase activity
H3N00_RS09240	COG0438	transferase activity, transferring glycosyl groups
H3N00_RS09245	COG0438	transferase activity, transferring glycosyl groups
H3N00_RS09250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H3N00_RS09255	COG0284	orotidine-5'-phosphate decarboxylase activity
H3N00_RS09260	COG0167	dihydroorotate dehydrogenase activity
H3N00_RS09265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H3N00_RS09270	COG0505	Belongs to the CarA family
H3N00_RS09275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H3N00_RS09280	COG0540	Belongs to the ATCase OTCase family
H3N00_RS09300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H3N00_RS09305	COG4856	YbbR-like protein
H3N00_RS09320	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H3N00_RS09325	COG2176	DNA-directed DNA polymerase activity
H3N00_RS09335	COG0802	atpase or kinase
H3N00_RS09340	COG0280	phosphate acetyltransferase
H3N00_RS09345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H3N00_RS09355	COG2076	Multidrug Resistance protein
H3N00_RS09360	COG2076	Multidrug Resistance protein
H3N00_RS09365	COG1126	abc transporter atp-binding protein
H3N00_RS09370	COG0765	amino acid transport
H3N00_RS09375	COG2814	Major facilitator Superfamily
H3N00_RS09390	COG0557	exoribonuclease II activity
H3N00_RS09400	COG2814	Major facilitator Superfamily
H3N00_RS09405	COG0154	amidase activity
H3N00_RS09425	COG0149	triose-phosphate isomerase activity
H3N00_RS09430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H3N00_RS09435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H3N00_RS09445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H3N00_RS09450	COG0492	ferredoxin-NADP+ reductase activity
H3N00_RS09470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H3N00_RS09475	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H3N00_RS09480	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H3N00_RS09485	COG1950	PFAM Membrane protein of
H3N00_RS09495	COG0589	response to stress
H3N00_RS09505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H3N00_RS09515	COG1177	transmembrane transport
H3N00_RS09525	COG3842	ATPase activity
H3N00_RS09535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H3N00_RS09540	COG0049	tRNA binding
H3N00_RS09545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H3N00_RS09555	COG4608	Belongs to the ABC transporter superfamily
H3N00_RS09560	COG0444	Belongs to the ABC transporter superfamily
H3N00_RS09565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3N00_RS09570	COG0601	transmembrane transport
H3N00_RS09580	COG0460	homoserine dehydrogenase
H3N00_RS09585	COG0626	cystathionine gamma-synthase activity
H3N00_RS09590	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H3N00_RS09605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H3N00_RS09610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H3N00_RS09625	COG1302	Protein conserved in bacteria
H3N00_RS09630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H3N00_RS09640	COG2017	converts alpha-aldose to the beta-anomer
H3N00_RS09650	COG4975	Glucose uptake
H3N00_RS09670	COG3850	Histidine kinase
H3N00_RS09670	COG5002	protein histidine kinase activity
H3N00_RS09675	COG0745	RESPONSE REGULATOR receiver
H3N00_RS09680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H3N00_RS09685	COG0402	S-adenosylhomocysteine deaminase activity
H3N00_RS09690	COG0673	inositol 2-dehydrogenase activity
H3N00_RS09695	COG0741	lytic transglycosylase activity
H3N00_RS09715	COG0668	transmembrane transport
H3N00_RS09725	COG1126	abc transporter atp-binding protein
H3N00_RS09730	COG0765	amino acid transport
H3N00_RS09770	COG0516	GMP reductase activity
H3N00_RS09855	COG2801	Transposase and inactivated derivatives
H3N00_RS09910	COG1869	D-ribose catabolic process
H3N00_RS09915	COG1609	Transcriptional regulator
H3N00_RS09935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H3N00_RS09950	COG1609	Transcriptional regulator
H3N00_RS09965	COG2223	nitrite transmembrane transporter activity
H3N00_RS09985	COG1116	anion transmembrane transporter activity
H3N00_RS09990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H3N00_RS10000	COG0285	dihydrofolate synthase activity
H3N00_RS10005	COG0302	gtp cyclohydrolase
H3N00_RS10010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H3N00_RS10010	COG0302	gtp cyclohydrolase
H3N00_RS10025	COG0561	phosphatase activity
H3N00_RS10035	COG4946	Tricorn protease homolog
H3N00_RS10035	COG1506	peptidase
H3N00_RS10035	COG0823	Involved in the tonB-independent uptake of proteins
H3N00_RS10040	COG1464	Belongs to the NlpA lipoprotein family
H3N00_RS10055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3N00_RS10070	COG1609	Transcriptional regulator
H3N00_RS10100	COG0577	efflux transmembrane transporter activity
H3N00_RS10105	COG1136	(ABC) transporter
H3N00_RS10110	COG3759	membrane
H3N00_RS10140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H3N00_RS10145	COG2235	arginine
H3N00_RS10155	COG2217	Heavy metal translocating P-type atpase
H3N00_RS10205	COG0438	transferase activity, transferring glycosyl groups
H3N00_RS10245	COG2814	Major facilitator Superfamily
H3N00_RS10250	COG2217	Heavy metal translocating P-type atpase
H3N00_RS10270	COG1309	transcriptional regulator
H3N00_RS10290	COG3711	transcriptional antiterminator
H3N00_RS10295	COG2723	6-phospho-beta-galactosidase activity
H3N00_RS10300	COG1940	carbohydrate kinase activity
H3N00_RS10325	COG2183	response to ionizing radiation
H3N00_RS10335	COG2873	o-acetylhomoserine
H3N00_RS10340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H3N00_RS10345	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H3N00_RS10425	COG2176	DNA-directed DNA polymerase activity
H3N00_RS10430	COG0442	prolyl-tRNA aminoacylation
H3N00_RS10435	COG0750	zinc metalloprotease
H3N00_RS10440	COG4589	Belongs to the CDS family
H3N00_RS10445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H3N00_RS10450	COG0561	phosphatase activity
H3N00_RS10455	COG2246	polysaccharide biosynthetic process
H3N00_RS10480	COG1811	Na channel or pump
H3N00_RS10485	COG1979	alcohol dehydrogenase
H3N00_RS10495	COG1174	glycine betaine transport
H3N00_RS10530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H3N00_RS10535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3N00_RS10535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H3N00_RS10540	COG0307	riboflavin synthase, alpha
H3N00_RS10545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H3N00_RS10545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H3N00_RS10550	COG2076	Multidrug Resistance protein
H3N00_RS10555	COG2076	Multidrug Resistance protein
H3N00_RS10565	COG1435	thymidine kinase activity
H3N00_RS10585	COG2801	Transposase and inactivated derivatives
H3N00_RS10600	COG1307	EDD domain protein, DegV family
H3N00_RS10605	COG0656	L-ascorbic acid biosynthetic process
H3N00_RS10610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H3N00_RS10635	COG4166	transmembrane transport
H3N00_RS10655	COG2826	transposase and inactivated derivatives, IS30 family
H3N00_RS10700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H3N00_RS10710	COG2252	PERMEase
H3N00_RS10720	COG0352	thiamine-phosphate diphosphorylase activity
H3N00_RS10725	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H3N00_RS10735	COG2814	Major facilitator Superfamily
H3N00_RS10740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H3N00_RS10750	COG2188	Transcriptional regulator
H3N00_RS10760	COG1136	(ABC) transporter
H3N00_RS10760	COG0577	efflux transmembrane transporter activity
H3N00_RS10770	COG0561	phosphatase activity
H3N00_RS10775	COG2169	Transcriptional regulator
H3N00_RS10775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H3N00_RS10780	COG0561	phosphatase activity
H3N00_RS10800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H3N00_RS10805	COG0772	Belongs to the SEDS family
H3N00_RS10815	COG1077	Cell shape determining protein MreB Mrl
H3N00_RS10820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H3N00_RS10845	COG2801	Transposase and inactivated derivatives
H3N00_RS10860	COG0446	pyridine nucleotide-disulphide oxidoreductase
H3N00_RS10870	COG0640	Transcriptional regulator
H3N00_RS10875	COG0628	permease
H3N00_RS10880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H3N00_RS10900	COG0386	Belongs to the glutathione peroxidase family
H3N00_RS10905	COG0588	phosphoglycerate mutase activity
H3N00_RS10920	COG0492	ferredoxin-NADP+ reductase activity
H3N00_RS10935	COG1744	ABC transporter substrate-binding protein PnrA-like
H3N00_RS10945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H3N00_RS10950	COG2832	Protein of unknown function (DUF454)
H3N00_RS10975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H3N00_RS10985	COG2814	Major facilitator Superfamily
H3N00_RS10990	COG0305	Participates in initiation and elongation during chromosome replication
H3N00_RS10995	COG0359	binds to the 23S rRNA
H3N00_RS11005	COG4608	Belongs to the ABC transporter superfamily
H3N00_RS11010	COG0444	Belongs to the ABC transporter superfamily
H3N00_RS11015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H3N00_RS11020	COG0601	transmembrane transport
H3N00_RS11030	COG0765	amino acid transport
H3N00_RS11035	COG0765	amino acid transport
H3N00_RS11040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H3N00_RS11045	COG1126	abc transporter atp-binding protein
H3N00_RS11060	COG0194	GDP metabolic process
H3N00_RS11065	COG1268	BioY protein
H3N00_RS11070	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H3N00_RS11070	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H3N00_RS11100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H3N00_RS11115	COG3973	AAA domain
H3N00_RS11135	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H3N00_RS11145	COG1696	Membrane protein involved in D-alanine export
H3N00_RS11165	COG2337	Toxic component of a toxin-antitoxin (TA) module
H3N00_RS11180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H3N00_RS11185	COG0504	CTP synthase activity
H3N00_RS11195	COG3343	RNA polymerase activity
H3N00_RS11200	COG0561	phosphatase activity
H3N00_RS11205	COG1078	dGTPase activity
H3N00_RS11215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H3N00_RS11220	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H3N00_RS11240	COG0745	RESPONSE REGULATOR receiver
H3N00_RS11270	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H3N00_RS11275	COG0629	single-stranded DNA binding
H3N00_RS11280	COG0360	Binds together with S18 to 16S ribosomal RNA
H3N00_RS11295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H3N00_RS11305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H3N00_RS11310	COG1051	belongs to the nudix hydrolase family
H3N00_RS11325	COG2814	Major facilitator Superfamily
H3N00_RS11330	COG1064	alcohol dehydrogenase
H3N00_RS11335	COG1074	ATP-dependent DNA helicase activity
H3N00_RS11340	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H3N00_RS11345	COG1012	belongs to the aldehyde dehydrogenase family
H3N00_RS11345	COG1454	alcohol dehydrogenase
H3N00_RS11355	COG1573	uracil-dna glycosylase
H3N00_RS11360	COG2801	Transposase and inactivated derivatives
H3N00_RS11380	COG2017	converts alpha-aldose to the beta-anomer
H3N00_RS11385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H3N00_RS11425	COG0783	Belongs to the Dps family
H3N00_RS11430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H3N00_RS11440	COG2801	Transposase and inactivated derivatives
H3N00_RS11465	COG2261	transglycosylase associated protein
H3N00_RS11485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H3N00_RS11495	COG0492	ferredoxin-NADP+ reductase activity
H3N00_RS11505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H3N00_RS11510	COG3118	belongs to the thioredoxin family
H3N00_RS11515	COG0640	Transcriptional regulator
H3N00_RS11525	COG0489	protein tyrosine kinase activity
H3N00_RS11550	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H3N00_RS11560	COG1088	dTDP-glucose 4,6-dehydratase activity
H3N00_RS11580	COG3620	sequence-specific DNA binding
H3N00_RS11610	COG2801	Transposase and inactivated derivatives
H3N00_RS11630	COG2801	Transposase and inactivated derivatives
H3N00_RS11640	COG1215	transferase activity, transferring glycosyl groups
H3N00_RS11655	COG2801	Transposase and inactivated derivatives
H3N00_RS11665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family