locus-tag	class	description
AO080_RS00045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AO080_RS00050	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AO080_RS00050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AO080_RS00055	COG0307	riboflavin synthase, alpha
AO080_RS00060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AO080_RS00060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AO080_RS00065	COG2076	Multidrug Resistance protein
AO080_RS00070	COG2076	Multidrug Resistance protein
AO080_RS00075	COG1435	thymidine kinase activity
AO080_RS00090	COG1307	EDD domain protein, DegV family
AO080_RS00095	COG0656	L-ascorbic acid biosynthetic process
AO080_RS00100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AO080_RS00105	COG2814	Major facilitator Superfamily
AO080_RS00125	COG4166	transmembrane transport
AO080_RS00165	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AO080_RS00170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AO080_RS00180	COG2252	PERMEase
AO080_RS00190	COG0352	thiamine-phosphate diphosphorylase activity
AO080_RS00195	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AO080_RS00205	COG2814	Major facilitator Superfamily
AO080_RS00210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AO080_RS00220	COG2188	Transcriptional regulator
AO080_RS00230	COG0577	efflux transmembrane transporter activity
AO080_RS00230	COG1136	(ABC) transporter
AO080_RS00240	COG0561	phosphatase activity
AO080_RS00245	COG2169	Transcriptional regulator
AO080_RS00245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AO080_RS00250	COG0561	phosphatase activity
AO080_RS00270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AO080_RS00275	COG0772	Belongs to the SEDS family
AO080_RS00285	COG1077	Cell shape determining protein MreB Mrl
AO080_RS00290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AO080_RS00295	COG1079	Belongs to the binding-protein-dependent transport system permease family
AO080_RS00300	COG4603	Belongs to the binding-protein-dependent transport system permease family
AO080_RS00305	COG3845	ABC transporter
AO080_RS00310	COG1744	ABC transporter substrate-binding protein PnrA-like
AO080_RS00315	COG0446	pyridine nucleotide-disulphide oxidoreductase
AO080_RS00325	COG0640	Transcriptional regulator
AO080_RS00330	COG0628	permease
AO080_RS00335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AO080_RS00355	COG0386	Belongs to the glutathione peroxidase family
AO080_RS00360	COG0588	phosphoglycerate mutase activity
AO080_RS00375	COG0492	ferredoxin-NADP+ reductase activity
AO080_RS00390	COG1744	ABC transporter substrate-binding protein PnrA-like
AO080_RS00395	COG1744	ABC transporter substrate-binding protein PnrA-like
AO080_RS00400	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AO080_RS00405	COG2832	Protein of unknown function (DUF454)
AO080_RS00430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AO080_RS00440	COG2814	Major facilitator Superfamily
AO080_RS00445	COG0305	Participates in initiation and elongation during chromosome replication
AO080_RS00450	COG0359	binds to the 23S rRNA
AO080_RS00460	COG4608	Belongs to the ABC transporter superfamily
AO080_RS00465	COG0444	Belongs to the ABC transporter superfamily
AO080_RS00470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AO080_RS00475	COG0601	transmembrane transport
AO080_RS00480	COG4166	transmembrane transport
AO080_RS00485	COG0765	amino acid transport
AO080_RS00490	COG0765	amino acid transport
AO080_RS00495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AO080_RS00500	COG1126	abc transporter atp-binding protein
AO080_RS00515	COG0194	GDP metabolic process
AO080_RS00520	COG1268	BioY protein
AO080_RS00525	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AO080_RS00525	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AO080_RS00550	COG2211	Major facilitator Superfamily
AO080_RS00555	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AO080_RS00570	COG3973	AAA domain
AO080_RS00590	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AO080_RS00600	COG1696	Membrane protein involved in D-alanine export
AO080_RS00620	COG2337	Toxic component of a toxin-antitoxin (TA) module
AO080_RS00635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AO080_RS00640	COG0504	CTP synthase activity
AO080_RS00650	COG3343	RNA polymerase activity
AO080_RS00655	COG0561	phosphatase activity
AO080_RS00660	COG1078	dGTPase activity
AO080_RS00670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AO080_RS00675	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AO080_RS00695	COG0745	RESPONSE REGULATOR receiver
AO080_RS00725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AO080_RS00730	COG0629	single-stranded DNA binding
AO080_RS00735	COG0360	Binds together with S18 to 16S ribosomal RNA
AO080_RS00750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AO080_RS00760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AO080_RS00765	COG1051	belongs to the nudix hydrolase family
AO080_RS00780	COG2814	Major facilitator Superfamily
AO080_RS00785	COG1064	alcohol dehydrogenase
AO080_RS00790	COG1074	ATP-dependent DNA helicase activity
AO080_RS00795	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AO080_RS00810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AO080_RS00815	COG0531	amino acid
AO080_RS00820	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AO080_RS00830	COG1902	pentaerythritol trinitrate reductase activity
AO080_RS00835	COG0626	cystathionine gamma-synthase activity
AO080_RS00850	COG2244	polysaccharide biosynthetic process
AO080_RS00860	COG0438	transferase activity, transferring glycosyl groups
AO080_RS00865	COG0495	leucyl-tRNA aminoacylation
AO080_RS00870	COG0671	phosphoesterase, PA-phosphatase related
AO080_RS00880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AO080_RS00905	COG2723	6-phospho-beta-galactosidase activity
AO080_RS00910	COG2801	Transposase and inactivated derivatives
AO080_RS00925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AO080_RS00940	COG0024	Methionine aminopeptidase
AO080_RS00950	COG1316	TRANSCRIPTIONal
AO080_RS00960	COG2205	protein histidine kinase activity
AO080_RS00965	COG0745	RESPONSE REGULATOR receiver
AO080_RS00970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AO080_RS01005	COG0308	aminopeptidase N
AO080_RS01010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AO080_RS01015	COG0542	response to heat
AO080_RS01030	COG0395	ABC-type sugar transport system, permease component
AO080_RS01035	COG1175	transmembrane transport
AO080_RS01040	COG2801	Transposase and inactivated derivatives
AO080_RS01085	COG2814	Major facilitator Superfamily
AO080_RS01105	COG1914	H( )-stimulated, divalent metal cation uptake system
AO080_RS01170	COG0438	transferase activity, transferring glycosyl groups
AO080_RS01195	COG2084	Dehydrogenase
AO080_RS01200	COG1028	Short-chain dehydrogenase reductase Sdr
AO080_RS01210	COG1620	l-lactate permease
AO080_RS01215	COG4989	oxidoreductase activity
AO080_RS01220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AO080_RS01225	COG2233	PERMEase
AO080_RS01240	COG1956	GAF domain-containing protein
AO080_RS01255	COG1132	(ABC) transporter
AO080_RS01260	COG1132	(ABC) transporter
AO080_RS01265	COG0747	negative chemotaxis
AO080_RS01270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AO080_RS01275	COG0601	transmembrane transport
AO080_RS01280	COG4608	Belongs to the ABC transporter superfamily
AO080_RS01285	COG0444	Belongs to the ABC transporter superfamily
AO080_RS01290	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AO080_RS01295	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AO080_RS01300	COG2211	Major facilitator Superfamily
AO080_RS01300	COG2190	(PTS) system
AO080_RS01315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AO080_RS01320	COG0436	Aminotransferase
AO080_RS01330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AO080_RS01335	COG2723	6-phospho-beta-galactosidase activity
AO080_RS01340	COG2723	6-phospho-beta-galactosidase activity
AO080_RS01345	COG1447	Phosphotransferase system cellobiose-specific component IIA
AO080_RS01350	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AO080_RS01355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AO080_RS01370	COG1215	transferase activity, transferring glycosyl groups
AO080_RS01385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AO080_RS01455	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AO080_RS01460	COG1737	Transcriptional regulator
AO080_RS01470	COG0656	L-ascorbic acid biosynthetic process
AO080_RS01475	COG2261	transglycosylase associated protein
AO080_RS01540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AO080_RS01545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AO080_RS01560	COG0037	tRNA processing
AO080_RS01570	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AO080_RS01575	COG2244	polysaccharide biosynthetic process
AO080_RS01580	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AO080_RS01585	COG0193	aminoacyl-tRNA hydrolase activity
AO080_RS01595	COG0058	SHG alpha-glucan phosphorylase activity
AO080_RS01600	COG0297	glycogen (starch) synthase activity
AO080_RS01605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AO080_RS01615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AO080_RS01620	COG1511	domain protein
AO080_RS01620	COG1511	domain protein
AO080_RS01625	COG1309	transcriptional regulator
AO080_RS01640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AO080_RS01645	COG0477	Major facilitator Superfamily
AO080_RS01650	COG1134	teichoic acid transport
AO080_RS01650	COG1388	LysM domain
AO080_RS01665	COG2115	Belongs to the xylose isomerase family
AO080_RS01675	COG2211	Major facilitator Superfamily
AO080_RS01680	COG3507	Belongs to the glycosyl hydrolase 43 family
AO080_RS01710	COG2818	Glycosylase
AO080_RS01715	COG1968	undecaprenyl-diphosphatase activity
AO080_RS01730	COG1695	Transcriptional regulator
AO080_RS01735	COG1983	PspC domain protein
AO080_RS01740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AO080_RS01745	COG0737	Belongs to the 5'-nucleotidase family
AO080_RS01760	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AO080_RS01775	COG1263	PTS System
AO080_RS01775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AO080_RS01780	COG1316	TRANSCRIPTIONal
AO080_RS01790	COG2131	deaminase
AO080_RS01795	COG4466	Protein conserved in bacteria
AO080_RS01800	COG1253	flavin adenine dinucleotide binding
AO080_RS01805	COG1253	flavin adenine dinucleotide binding
AO080_RS01810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AO080_RS01815	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AO080_RS01820	COG0084	hydrolase, TatD family'
AO080_RS01830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AO080_RS01830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AO080_RS01875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AO080_RS01895	COG2801	Transposase and inactivated derivatives
AO080_RS01905	COG1368	sulfuric ester hydrolase activity
AO080_RS01910	COG2153	protein acetylation
AO080_RS01925	COG0187	DNA topoisomerase II activity
AO080_RS01930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AO080_RS01935	COG2501	S4 domain
AO080_RS01940	COG0592	DNA-directed DNA polymerase activity
AO080_RS01945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AO080_RS01950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AO080_RS01955	COG0594	ribonuclease P activity
AO080_RS01960	COG0706	membrane insertase activity
AO080_RS01970	COG1120	ATPase activity
AO080_RS01980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AO080_RS01995	COG0569	domain protein
AO080_RS02000	COG1113	amino acid transport
AO080_RS02020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AO080_RS02030	COG0446	pyridine nucleotide-disulphide oxidoreductase
AO080_RS02040	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AO080_RS02045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AO080_RS02055	COG1136	(ABC) transporter
AO080_RS02060	COG0577	efflux transmembrane transporter activity
AO080_RS02065	COG2409	Drug exporters of the RND superfamily
AO080_RS02065	COG1033	growth of symbiont in host cell
AO080_RS02070	COG0561	phosphatase activity
AO080_RS02080	COG0328	RNA-DNA hybrid ribonuclease activity
AO080_RS02100	COG3152	Membrane
AO080_RS02105	COG2252	PERMEase
AO080_RS02145	COG1881	PFAM PEBP family protein
AO080_RS02185	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AO080_RS02185	COG0517	IMP dehydrogenase activity
AO080_RS02190	COG2723	6-phospho-beta-galactosidase activity
AO080_RS02220	COG0697	spore germination
AO080_RS02235	COG0561	phosphatase activity
AO080_RS02245	COG1744	ABC transporter substrate-binding protein PnrA-like
AO080_RS02250	COG0137	argininosuccinate synthase activity
AO080_RS02255	COG0165	Argininosuccinate lyase
AO080_RS02260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AO080_RS02265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AO080_RS02270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AO080_RS02275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AO080_RS02280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AO080_RS02285	COG0505	Belongs to the CarA family
AO080_RS02290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AO080_RS02310	COG1131	(ABC) transporter
AO080_RS02330	COG0789	Transcriptional regulator
AO080_RS02335	COG1028	Short-chain dehydrogenase reductase Sdr
AO080_RS02345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AO080_RS02355	COG0697	spore germination
AO080_RS02360	COG1744	ABC transporter substrate-binding protein PnrA-like
AO080_RS02380	COG1846	Transcriptional regulator
AO080_RS02385	COG1132	(ABC) transporter
AO080_RS02395	COG0656	L-ascorbic acid biosynthetic process
AO080_RS02405	COG4619	ABC transporter
AO080_RS02410	COG0390	transport system, permease component
AO080_RS02420	COG1131	(ABC) transporter
AO080_RS02430	COG1126	abc transporter atp-binding protein
AO080_RS02435	COG0765	amino acid transport
AO080_RS02440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AO080_RS02445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AO080_RS02450	COG1254	Belongs to the acylphosphatase family
AO080_RS02460	COG0392	lysyltransferase activity
AO080_RS02460	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AO080_RS02470	COG0628	permease
AO080_RS02500	COG1113	amino acid transport
AO080_RS02525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AO080_RS02530	COG0456	acetyltransferase
AO080_RS02530	COG0454	-acetyltransferase
AO080_RS02540	COG2855	membrane
AO080_RS02550	COG2855	membrane
AO080_RS02555	COG0583	DNA-binding transcription factor activity
AO080_RS02565	COG2070	2-Nitropropane dioxygenase
AO080_RS02580	COG1228	amidohydrolase
AO080_RS02585	COG0531	amino acid
AO080_RS02595	COG3223	Belongs to the PsiE family
AO080_RS02605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AO080_RS02615	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AO080_RS02625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AO080_RS02630	COG4166	transmembrane transport
AO080_RS02635	COG2267	carboxylic ester hydrolase activity
AO080_RS02640	COG1131	(ABC) transporter
AO080_RS02665	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AO080_RS02680	COG4975	Glucose uptake
AO080_RS02690	COG0531	amino acid
AO080_RS02695	COG1113	amino acid transport
AO080_RS02700	COG0531	amino acid
AO080_RS02705	COG0252	asparaginase activity
AO080_RS02710	COG4443	Transcriptional Coactivator p15 (PC4)
AO080_RS02720	COG2226	methyltransferase
AO080_RS02725	COG1335	isochorismatase
AO080_RS02730	COG2050	protein possibly involved in aromatic compounds catabolism
AO080_RS02735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AO080_RS02740	COG0318	PFAM AMP-dependent synthetase and ligase
AO080_RS02755	COG0745	RESPONSE REGULATOR receiver
AO080_RS02760	COG5002	protein histidine kinase activity
AO080_RS02770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AO080_RS02775	COG1194	a g-specific adenine glycosylase
AO080_RS02785	COG0357	Ribosomal RNA small subunit methyltransferase G
AO080_RS02790	COG1192	Involved in chromosome partitioning
AO080_RS02795	COG1475	DNA binding
AO080_RS02800	COG4481	Protein conserved in bacteria
AO080_RS02805	COG0012	GTP binding
AO080_RS02815	COG0745	RESPONSE REGULATOR receiver
AO080_RS02825	COG1686	Belongs to the peptidase S11 family
AO080_RS02875	COG3104	oligopeptide transport
AO080_RS02880	COG0477	Major facilitator Superfamily
AO080_RS02885	COG4975	Glucose uptake
AO080_RS02930	COG3091	SprT-like family
AO080_RS02935	COG2755	lipolytic protein G-D-S-L family
AO080_RS02935	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AO080_RS02940	COG1846	Transcriptional regulator
AO080_RS02950	COG1121	(ABC) transporter
AO080_RS02955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AO080_RS02960	COG1373	ATPase (AAA superfamily
AO080_RS02965	COG0488	(ABC) transporter
AO080_RS02970	COG0534	Mate efflux family protein
AO080_RS02985	COG3940	Belongs to the glycosyl hydrolase 43 family
AO080_RS03005	COG2160	L-arabinose isomerase activity
AO080_RS03010	COG0656	L-ascorbic acid biosynthetic process
AO080_RS03040	COG0765	amino acid transport
AO080_RS03070	COG1215	transferase activity, transferring glycosyl groups
AO080_RS03080	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AO080_RS03095	COG1418	mRNA catabolic process
AO080_RS03100	COG2814	Major facilitator Superfamily
AO080_RS03120	COG2188	Transcriptional regulator
AO080_RS03125	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AO080_RS03145	COG1216	Glycosyl transferase, family 2
AO080_RS03150	COG2801	Transposase and inactivated derivatives
AO080_RS03160	COG0438	transferase activity, transferring glycosyl groups
AO080_RS03165	COG1216	Glycosyl transferase, family 2
AO080_RS03165	COG1442	glycosyl transferase family 8
AO080_RS03175	COG5039	Polysaccharide pyruvyl transferase
AO080_RS03225	COG3590	peptidase
AO080_RS03235	COG1012	belongs to the aldehyde dehydrogenase family
AO080_RS03235	COG1454	alcohol dehydrogenase
AO080_RS03250	COG1373	ATPase (AAA superfamily
AO080_RS03255	COG0708	Exodeoxyribonuclease III
AO080_RS03275	COG0588	phosphoglycerate mutase activity
AO080_RS03280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AO080_RS03295	COG1132	(ABC) transporter
AO080_RS03300	COG1132	(ABC) transporter
AO080_RS03305	COG1373	ATPase (AAA superfamily
AO080_RS03330	COG0110	maltose O-acetyltransferase activity
AO080_RS03340	COG1482	cell wall glycoprotein biosynthetic process
AO080_RS03345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AO080_RS03350	COG3442	glutamine amidotransferase
AO080_RS03360	COG1435	thymidine kinase activity
AO080_RS03365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AO080_RS03370	COG2890	protein-(glutamine-N5) methyltransferase activity
AO080_RS03375	COG0009	L-threonylcarbamoyladenylate synthase
AO080_RS03380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AO080_RS03385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AO080_RS03390	COG0702	epimerase
AO080_RS03400	COG2233	PERMEase
AO080_RS03405	COG0356	it plays a direct role in the translocation of protons across the membrane
AO080_RS03410	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AO080_RS03415	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AO080_RS03420	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AO080_RS03425	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AO080_RS03430	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AO080_RS03435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AO080_RS03440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AO080_RS03445	COG1876	peptidase activity
AO080_RS03450	COG1428	Deoxynucleoside kinase
AO080_RS03455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AO080_RS03480	COG4463	regulation of RNA biosynthetic process
AO080_RS03485	COG0542	response to heat
AO080_RS03490	COG0085	RNA polymerase activity
AO080_RS03510	COG1979	alcohol dehydrogenase
AO080_RS03530	COG1309	transcriptional regulator
AO080_RS03535	COG0500	methyltransferase
AO080_RS03565	COG1051	belongs to the nudix hydrolase family
AO080_RS03580	COG3620	sequence-specific DNA binding
AO080_RS03590	COG2807	transmembrane transport
AO080_RS03600	COG2813	Specifically methylates the guanine in position
AO080_RS03615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AO080_RS03640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AO080_RS03645	COG3870	Protein conserved in bacteria
AO080_RS03665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AO080_RS03670	COG1214	PFAM Peptidase M22, glycoprotease
AO080_RS03685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AO080_RS03690	COG0142	geranyltranstransferase activity
AO080_RS03695	COG0051	transcription antitermination factor activity, RNA binding
AO080_RS03700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AO080_RS03710	COG0089	rRNA binding
AO080_RS03715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AO080_RS03720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AO080_RS03725	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AO080_RS03730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AO080_RS03735	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AO080_RS03740	COG0255	Belongs to the universal ribosomal protein uL29 family
AO080_RS03750	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AO080_RS03755	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AO080_RS03760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AO080_RS03765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AO080_RS03770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AO080_RS03775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AO080_RS03780	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AO080_RS03785	COG1841	ribosomal large subunit assembly
AO080_RS03790	COG0200	Binds to the 23S rRNA
AO080_RS03805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AO080_RS03810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AO080_RS03815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AO080_RS03820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AO080_RS03825	COG0202	RNA polymerase activity
AO080_RS03830	COG0203	ribosomal protein L17
AO080_RS03855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AO080_RS03870	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AO080_RS03895	COG0583	DNA-binding transcription factor activity
AO080_RS03900	COG0114	fumarate hydratase activity
AO080_RS03905	COG1053	succinate dehydrogenase
AO080_RS03910	COG0471	metal ion transport
AO080_RS03915	COG0039	L-malate dehydrogenase activity
AO080_RS03920	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AO080_RS03925	COG0215	cysteine-tRNA ligase activity
AO080_RS03930	COG0626	cystathionine gamma-synthase activity
AO080_RS03935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AO080_RS03940	COG1464	Belongs to the NlpA lipoprotein family
AO080_RS03945	COG1854	S-ribosylhomocysteine lyase activity
AO080_RS03950	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AO080_RS03955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AO080_RS03965	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AO080_RS03970	COG0250	Participates in transcription elongation, termination and antitermination
AO080_RS03975	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AO080_RS03980	COG0081	regulation of translation
AO080_RS03985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AO080_RS03990	COG0222	ribosome binding
AO080_RS04000	COG1121	(ABC) transporter
AO080_RS04005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AO080_RS04010	COG0803	Belongs to the bacterial solute-binding protein 9 family
AO080_RS04015	COG1252	NADH dehydrogenase
AO080_RS04025	COG1122	ATPase activity
AO080_RS04030	COG1122	ATPase activity
AO080_RS04040	COG0101	tRNA pseudouridine synthase activity
AO080_RS04045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AO080_RS04060	COG4221	oxidoreductase activity
AO080_RS04085	COG0028	Belongs to the TPP enzyme family
AO080_RS04095	COG1573	uracil-dna glycosylase
AO080_RS04120	COG0671	phosphoesterase, PA-phosphatase related
AO080_RS04130	COG2814	Major facilitator Superfamily
AO080_RS04135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AO080_RS04145	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AO080_RS04150	COG1481	regulation of sporulation
AO080_RS04155	COG0740	serine-type endopeptidase activity
AO080_RS04170	COG1263	PTS System
AO080_RS04170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AO080_RS04180	COG1914	H( )-stimulated, divalent metal cation uptake system
AO080_RS04200	COG4974	Belongs to the 'phage' integrase family
AO080_RS04260	COG0489	protein tyrosine kinase activity
AO080_RS04265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AO080_RS04290	COG1216	Glycosyl transferase, family 2
AO080_RS04295	COG0438	transferase activity, transferring glycosyl groups
AO080_RS04300	COG0728	peptidoglycan biosynthetic process
AO080_RS04310	COG1316	TRANSCRIPTIONal
AO080_RS04315	COG4464	protein tyrosine phosphatase activity
AO080_RS04345	COG0039	L-malate dehydrogenase activity
AO080_RS04350	COG0028	Belongs to the TPP enzyme family
AO080_RS04355	COG3527	Alpha-acetolactate decarboxylase
AO080_RS04365	COG3942	CHAP domain
AO080_RS04365	COG1388	LysM domain
AO080_RS04370	COG0791	NLP P60 protein
AO080_RS04380	COG0756	dUTP diphosphatase activity
AO080_RS04390	COG4956	integral membrane protein (PIN domain superfamily)
AO080_RS04400	COG0653	protein targeting
AO080_RS04405	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AO080_RS04425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AO080_RS04435	COG1733	regulation of RNA biosynthetic process
AO080_RS04440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AO080_RS04445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AO080_RS04445	COG0072	phenylalanine-tRNA ligase activity
AO080_RS04450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AO080_RS04455	COG0514	ATP-dependent DNA helicase (RecQ)
AO080_RS04460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AO080_RS04470	COG0768	penicillin binding
AO080_RS04475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AO080_RS04490	COG1940	carbohydrate kinase activity
AO080_RS04505	COG3942	CHAP domain
AO080_RS04525	COG0584	glycerophosphoryl diester phosphodiesterase
AO080_RS04530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AO080_RS04535	COG0789	Transcriptional regulator
AO080_RS04540	COG0174	glutamine synthetase
AO080_RS04565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AO080_RS04570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AO080_RS04590	COG1132	(ABC) transporter
AO080_RS04595	COG0778	Nitroreductase
AO080_RS04600	COG1169	isochorismate synthase
AO080_RS04605	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AO080_RS04610	COG0596	Alpha beta hydrolase
AO080_RS04615	COG4948	Mandelate Racemase Muconate Lactonizing
AO080_RS04620	COG0006	proline dipeptidase activity
AO080_RS04635	COG0737	Belongs to the 5'-nucleotidase family
AO080_RS04640	COG4470	Protein conserved in bacteria
AO080_RS04645	COG0647	UMP catabolic process
AO080_RS04650	COG4166	transmembrane transport
AO080_RS04655	COG0673	inositol 2-dehydrogenase activity
AO080_RS04685	COG0573	inorganic phosphate transmembrane transporter activity
AO080_RS04690	COG0581	inorganic phosphate transmembrane transporter activity
AO080_RS04695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AO080_RS04700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AO080_RS04705	COG0704	Plays a role in the regulation of phosphate uptake
AO080_RS04710	COG2137	regulation of response to DNA damage stimulus
AO080_RS04745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AO080_RS04755	COG5506	Protein of unknown function (DUF1694)
AO080_RS04765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AO080_RS04885	COG1272	protein, Hemolysin III
AO080_RS04915	COG0525	valine-tRNA ligase activity
AO080_RS04925	COG0285	dihydrofolate synthase activity
AO080_RS04945	COG0488	(ABC) transporter
AO080_RS04950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AO080_RS04955	COG0459	protein refolding
AO080_RS04960	COG0531	amino acid
AO080_RS04970	COG1181	Belongs to the D-alanine--D-alanine ligase family
AO080_RS04975	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AO080_RS04980	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AO080_RS04990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AO080_RS04995	COG1713	HD superfamily hydrolase involved in NAD metabolism
AO080_RS05000	COG0799	negative regulation of ribosome biogenesis
AO080_RS05005	COG2226	methyltransferase
AO080_RS05010	COG1323	Belongs to the UPF0348 family
AO080_RS05020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AO080_RS05025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AO080_RS05125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AO080_RS05130	COG3764	Sortase (surface protein transpeptidase)
AO080_RS05135	COG0363	glucosamine-6-phosphate deaminase activity
AO080_RS05140	COG0776	regulation of translation
AO080_RS05150	COG0577	efflux transmembrane transporter activity
AO080_RS05155	COG1136	(ABC) transporter
AO080_RS05170	COG4720	Psort location CytoplasmicMembrane, score
AO080_RS05175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AO080_RS05180	COG1570	exodeoxyribonuclease VII activity
AO080_RS05190	COG0142	geranyltranstransferase activity
AO080_RS05195	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AO080_RS05200	COG1438	arginine binding
AO080_RS05205	COG0497	DNA recombination
AO080_RS05215	COG0194	GDP metabolic process
AO080_RS05225	COG0586	Pfam SNARE associated Golgi protein
AO080_RS05230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AO080_RS05235	COG1098	S1 RNA binding domain
AO080_RS05350	COG4684	Psort location CytoplasmicMembrane, score
AO080_RS05355	COG1271	oxidase subunit
AO080_RS05360	COG1294	oxidase, subunit
AO080_RS05365	COG4988	ABC transporter
AO080_RS05370	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AO080_RS05375	COG1388	LysM domain
AO080_RS05375	COG1705	Flagellar rod assembly protein muramidase FlgJ
AO080_RS05380	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AO080_RS05390	COG1278	Cold shock
AO080_RS05395	COG0494	nUDIX hydrolase
AO080_RS05405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AO080_RS05410	COG0346	lactoylglutathione lyase activity
AO080_RS05415	COG0400	carboxylic ester hydrolase activity
AO080_RS05425	COG0741	lytic transglycosylase activity
AO080_RS05445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AO080_RS05450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AO080_RS05455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AO080_RS05465	COG4120	Belongs to the binding-protein-dependent transport system permease family
AO080_RS05475	COG0038	chloride channel
AO080_RS05480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AO080_RS05485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AO080_RS05490	COG1307	EDD domain protein, DegV family
AO080_RS05495	COG2190	(PTS) system
AO080_RS05495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AO080_RS05495	COG1263	PTS System
AO080_RS05515	COG2003	Belongs to the UPF0758 family
AO080_RS05520	COG1077	Cell shape determining protein MreB Mrl
AO080_RS05530	COG3338	carbonate dehydratase activity
AO080_RS05540	COG0765	amino acid transport
AO080_RS05545	COG1126	abc transporter atp-binding protein
AO080_RS05550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AO080_RS05555	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AO080_RS05555	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AO080_RS05560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AO080_RS05565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AO080_RS05570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AO080_RS05575	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AO080_RS05585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AO080_RS05595	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AO080_RS05600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AO080_RS05605	COG0138	bifunctional purine biosynthesis protein purh
AO080_RS05610	COG0151	Belongs to the GarS family
AO080_RS05615	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AO080_RS05630	COG0446	pyridine nucleotide-disulphide oxidoreductase
AO080_RS05650	COG0833	amino acid
AO080_RS05660	COG2264	protein methyltransferase activity
AO080_RS05665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AO080_RS05675	COG2001	Belongs to the MraZ family
AO080_RS05680	COG0275	rRNA processing
AO080_RS05690	COG0768	penicillin binding
AO080_RS05695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AO080_RS05700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AO080_RS05705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AO080_RS05710	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AO080_RS05715	COG0849	cell division
AO080_RS05725	COG1799	cell septum assembly
AO080_RS05740	COG3599	regulation of cell shape
AO080_RS05760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AO080_RS05765	COG0217	transcriptional regulatory protein
AO080_RS05770	COG2252	PERMEase
AO080_RS05775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AO080_RS05815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AO080_RS05820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AO080_RS05825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AO080_RS05830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AO080_RS05830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AO080_RS05835	COG0631	protein serine/threonine phosphatase activity
AO080_RS05840	COG2815	serine threonine protein kinase
AO080_RS05840	COG0515	serine threonine protein kinase
AO080_RS05845	COG1162	GTPase activity
AO080_RS05850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AO080_RS05860	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AO080_RS05870	COG1461	Dihydroxyacetone kinase
AO080_RS05885	COG0438	transferase activity, transferring glycosyl groups
AO080_RS05895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AO080_RS05900	COG0416	fatty acid biosynthetic process
AO080_RS05905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AO080_RS05910	COG0571	ribonuclease III activity
AO080_RS05915	COG1196	nuclear chromosome segregation
AO080_RS05920	COG0552	protein localization to endoplasmic reticulum
AO080_RS05925	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AO080_RS05930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AO080_RS05945	COG0228	four-way junction DNA binding
AO080_RS05950	COG0582	viral genome integration into host DNA
AO080_RS06210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AO080_RS06215	COG0336	Belongs to the RNA methyltransferase TrmD family
AO080_RS06220	COG0335	large ribosomal subunit rRNA binding
AO080_RS06230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AO080_RS06235	COG1942	4-Oxalocrotonate Tautomerase
AO080_RS06240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AO080_RS06250	COG1428	Deoxynucleoside kinase
AO080_RS06255	COG1970	mechanosensitive ion channel activity
AO080_RS06260	COG0561	phosphatase activity
AO080_RS06325	COG3853	Toxic anion resistance protein (TelA)
AO080_RS06330	COG1393	Belongs to the ArsC family
AO080_RS06335	COG4862	establishment of competence for transformation
AO080_RS06340	COG2723	6-phospho-beta-galactosidase activity
AO080_RS06345	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AO080_RS06350	COG1447	Phosphotransferase system cellobiose-specific component IIA
AO080_RS06355	COG2723	6-phospho-beta-galactosidase activity
AO080_RS06360	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AO080_RS06370	COG1164	Oligoendopeptidase f
AO080_RS06375	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AO080_RS06390	COG1609	Transcriptional regulator
AO080_RS06395	COG0006	proline dipeptidase activity
AO080_RS06475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AO080_RS06480	COG3425	synthase
AO080_RS06495	COG0860	N-Acetylmuramoyl-L-alanine amidase
AO080_RS06500	COG0124	histidyl-tRNA synthetase
AO080_RS06505	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AO080_RS06520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AO080_RS06525	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AO080_RS06530	COG1610	YqeY-like protein
AO080_RS06535	COG1702	phosphate starvation-inducible protein PhoH
AO080_RS06540	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AO080_RS06545	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AO080_RS06550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AO080_RS06555	COG1381	Involved in DNA repair and RecF pathway recombination
AO080_RS06565	COG0752	glycyl-tRNA synthetase alpha subunit
AO080_RS06570	COG0751	glycine-tRNA ligase activity
AO080_RS06730	COG1783	phage Terminase large subunit
AO080_RS06755	COG0228	four-way junction DNA binding
AO080_RS06840	COG2706	6-phosphogluconolactonase activity
AO080_RS06845	COG0628	permease
AO080_RS06855	COG1674	ftsk spoiiie
AO080_RS06865	COG4152	abc transporter atp-binding protein
AO080_RS06870	COG1668	transmembrane transport
AO080_RS06880	COG0322	excinuclease ABC activity
AO080_RS06885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AO080_RS06890	COG1739	Uncharacterized protein family UPF0029
AO080_RS06905	COG0517	IMP dehydrogenase activity
AO080_RS06905	COG0516	GMP reductase activity
AO080_RS06910	COG0517	IMP dehydrogenase activity
AO080_RS06910	COG0516	GMP reductase activity
AO080_RS06915	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AO080_RS06920	COG0632	four-way junction helicase activity
AO080_RS06925	COG2255	four-way junction helicase activity
AO080_RS06930	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AO080_RS06965	COG0343	queuine tRNA-ribosyltransferase activity
AO080_RS06970	COG1862	Preprotein translocase
AO080_RS06975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AO080_RS06980	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AO080_RS06985	COG0513	Belongs to the DEAD box helicase family
AO080_RS06990	COG1929	Belongs to the glycerate kinase type-1 family
AO080_RS06995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AO080_RS07015	COG3906	Belongs to the UPF0473 family
AO080_RS07020	COG1555	photosystem II stabilization
AO080_RS07020	COG1596	polysaccharide export
AO080_RS07035	COG1466	dna polymerase III delta subunit
AO080_RS07040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AO080_RS07045	COG0268	Binds directly to 16S ribosomal RNA
AO080_RS07070	COG0544	peptidyl-prolyl cis-trans isomerase activity
AO080_RS07075	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AO080_RS07080	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AO080_RS07100	COG1193	negative regulation of DNA recombination
AO080_RS07120	COG3118	belongs to the thioredoxin family
AO080_RS07125	COG0187	DNA topoisomerase II activity
AO080_RS07130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AO080_RS07135	COG3527	Alpha-acetolactate decarboxylase
AO080_RS07140	COG1473	amidohydrolase
AO080_RS07155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AO080_RS07175	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AO080_RS07180	COG3201	nicotinamide mononucleotide transporter
AO080_RS07215	COG0028	Belongs to the TPP enzyme family
AO080_RS07225	COG0277	FAD linked oxidase domain protein
AO080_RS07230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AO080_RS07235	COG0248	Ppx GppA phosphatase
AO080_RS07250	COG2801	Transposase and inactivated derivatives
AO080_RS07260	COG0277	FAD linked oxidase domain protein
AO080_RS07265	COG0436	Aminotransferase
AO080_RS07280	COG1464	Belongs to the NlpA lipoprotein family
AO080_RS07290	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AO080_RS07295	COG0351	phosphomethylpyrimidine kinase
AO080_RS07300	COG0352	thiamine-phosphate diphosphorylase activity
AO080_RS07325	COG1028	Short-chain dehydrogenase reductase Sdr
AO080_RS07335	COG1940	carbohydrate kinase activity
AO080_RS07410	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AO080_RS07415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AO080_RS07430	COG2357	RelA SpoT domain protein
AO080_RS07435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AO080_RS07440	COG0564	pseudouridine synthase activity
AO080_RS07445	COG2239	Acts as a magnesium transporter
AO080_RS07450	COG2814	Major facilitator Superfamily
AO080_RS07465	COG2801	Transposase and inactivated derivatives
AO080_RS07505	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AO080_RS07515	COG1846	Transcriptional regulator
AO080_RS07520	COG0456	acetyltransferase
AO080_RS07575	COG1279	arginine transmembrane transporter activity
AO080_RS07595	COG2801	Transposase and inactivated derivatives
AO080_RS07605	COG0384	phenazine biosynthesis protein PhzF
AO080_RS07615	COG1621	beta-fructofuranosidase activity
AO080_RS07635	COG1033	growth of symbiont in host cell
AO080_RS07635	COG2409	Drug exporters of the RND superfamily
AO080_RS07650	COG0583	DNA-binding transcription factor activity
AO080_RS07655	COG1063	alcohol dehydrogenase
AO080_RS07670	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AO080_RS07685	COG0738	Major facilitator superfamily
AO080_RS07690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AO080_RS07710	COG1304	FMN binding
AO080_RS07725	COG0779	Required for maturation of 30S ribosomal subunits
AO080_RS07730	COG0195	Participates in both transcription termination and antitermination
AO080_RS07735	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AO080_RS07745	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AO080_RS07750	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AO080_RS07755	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AO080_RS07760	COG1252	NADH dehydrogenase
AO080_RS07770	COG0196	riboflavin kinase activity
AO080_RS07775	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AO080_RS07780	COG3142	Participates in the control of copper homeostasis
AO080_RS07800	COG1307	EDD domain protein, DegV family
AO080_RS07805	COG1307	EDD domain protein, DegV family
AO080_RS07810	COG2755	lipolytic protein G-D-S-L family
AO080_RS07820	COG4479	Belongs to the UPF0346 family
AO080_RS07830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AO080_RS07835	COG0758	DNA mediated transformation
AO080_RS07840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AO080_RS07845	COG4974	Belongs to the 'phage' integrase family
AO080_RS07855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AO080_RS07875	COG3448	diguanylate cyclase activity
AO080_RS07875	COG4175	Glycine betaine
AO080_RS07885	COG0446	pyridine nucleotide-disulphide oxidoreductase
AO080_RS07890	COG1464	Belongs to the NlpA lipoprotein family
AO080_RS07895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AO080_RS07900	COG1597	lipid kinase activity
AO080_RS07905	COG1011	Hydrolase
AO080_RS07925	COG5503	Protein of unknown function (DUF1447)
AO080_RS07940	COG0242	peptide deformylase activity
AO080_RS07945	COG4476	Belongs to the UPF0223 family
AO080_RS07950	COG0483	inositol monophosphate 1-phosphatase activity
AO080_RS07955	COG1217	gtp-binding protein TYPA
AO080_RS07960	COG0772	Belongs to the SEDS family
AO080_RS07965	COG4471	UPF0298 protein
AO080_RS07970	COG0742	ribosomal rna small subunit methyltransferase
AO080_RS07975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AO080_RS07980	COG3480	Lon protease (S16) C-terminal proteolytic domain
AO080_RS07985	COG0477	Major facilitator Superfamily
AO080_RS07995	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AO080_RS08000	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AO080_RS08005	COG0358	DNA primase activity
AO080_RS08010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AO080_RS08040	COG0745	RESPONSE REGULATOR receiver
AO080_RS08045	COG5002	protein histidine kinase activity
AO080_RS08050	COG0572	uridine kinase
AO080_RS08055	COG1363	Peptidase, m42
AO080_RS08060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AO080_RS08070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AO080_RS08075	COG0670	Belongs to the BI1 family
AO080_RS08080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AO080_RS08080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AO080_RS08085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AO080_RS08090	COG0237	dephospho-CoA kinase activity
AO080_RS08100	COG1484	DNA-dependent DNA replication
AO080_RS08115	COG0745	RESPONSE REGULATOR receiver
AO080_RS08120	COG5002	protein histidine kinase activity
AO080_RS08130	COG1705	Flagellar rod assembly protein muramidase FlgJ
AO080_RS08130	COG3942	CHAP domain
AO080_RS08155	COG0706	membrane insertase activity
AO080_RS08165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AO080_RS08175	COG1304	FMN binding
AO080_RS08195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AO080_RS08195	COG1199	ATP-dependent helicase activity
AO080_RS08205	COG0017	Asparaginyl-tRNA synthetase
AO080_RS08210	COG3935	DnaD domain protein
AO080_RS08220	COG3331	DNA recombination
AO080_RS08225	COG4474	Belongs to the UPF0398 family
AO080_RS08230	COG3599	regulation of cell shape
AO080_RS08240	COG0116	Belongs to the methyltransferase superfamily
AO080_RS08250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AO080_RS08270	COG0556	nucleotide-excision repair
AO080_RS08280	COG0439	Biotin carboxylase
AO080_RS08285	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AO080_RS08290	COG0825	malonyl-CoA metabolic process
AO080_RS08295	COG3104	oligopeptide transport
AO080_RS08300	COG0363	glucosamine-6-phosphate deaminase activity
AO080_RS08310	COG0537	adenosine 5'-monophosphoramidase activity
AO080_RS08315	COG1131	(ABC) transporter
AO080_RS08325	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AO080_RS08330	COG1719	4-vinyl reductase, 4VR
AO080_RS08335	COG1397	ADP-ribosylglycohydrolase
AO080_RS08360	COG0446	pyridine nucleotide-disulphide oxidoreductase
AO080_RS08365	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
AO080_RS08370	COG1349	DNA-binding transcription factor activity
AO080_RS08375	COG1105	Belongs to the carbohydrate kinase PfkB family
AO080_RS08380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AO080_RS08380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AO080_RS08380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AO080_RS08390	COG1609	Transcriptional regulator
AO080_RS08410	COG0306	phosphate transporter
AO080_RS08425	COG2723	6-phospho-beta-galactosidase activity
AO080_RS08445	COG0531	amino acid
AO080_RS08455	COG0481	GTPase activity
AO080_RS08485	COG1028	Short-chain dehydrogenase reductase Sdr
AO080_RS08490	COG4708	membrane
AO080_RS08500	COG0531	amino acid
AO080_RS08510	COG4221	oxidoreductase activity
AO080_RS08520	COG0281	malic enzyme
AO080_RS08530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AO080_RS08545	COG1136	(ABC) transporter
AO080_RS08550	COG0577	efflux transmembrane transporter activity
AO080_RS08560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AO080_RS08570	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AO080_RS08575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AO080_RS08605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AO080_RS08610	COG2384	SAM-dependent methyltransferase
AO080_RS08615	COG0071	Belongs to the small heat shock protein (HSP20) family
AO080_RS08620	COG0457	Tetratricopeptide repeat
AO080_RS08655	COG0419	ATPase involved in DNA repair
AO080_RS08660	COG0420	3'-5' exonuclease activity
AO080_RS08670	COG2807	transmembrane transport
AO080_RS08675	COG4720	Psort location CytoplasmicMembrane, score
AO080_RS08680	COG0351	phosphomethylpyrimidine kinase
AO080_RS08690	COG1160	GTP binding
AO080_RS08695	COG0539	negative regulation of cytoplasmic translation
AO080_RS08700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AO080_RS08710	COG0514	ATP-dependent DNA helicase (RecQ)
AO080_RS08720	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AO080_RS08735	COG1187	pseudouridine synthase activity
AO080_RS08740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AO080_RS08745	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AO080_RS08760	COG2996	Protein conserved in bacteria
AO080_RS08770	COG0475	glutathione-regulated potassium exporter activity
AO080_RS08780	COG1490	D-aminoacyl-tRNA deacylase activity
AO080_RS08785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AO080_RS08790	COG0587	DNA-directed DNA polymerase activity
AO080_RS08800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AO080_RS08805	COG0488	(ABC) transporter
AO080_RS08810	COG0617	tRNA 3'-terminal CCA addition
AO080_RS08825	COG1136	(ABC) transporter
AO080_RS08840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AO080_RS08845	COG0004	ammonium transporteR
AO080_RS08855	COG5263	repeat protein
AO080_RS08855	COG0366	Alpha amylase catalytic
AO080_RS08860	COG1316	TRANSCRIPTIONal
AO080_RS08865	COG1216	Glycosyl transferase, family 2
AO080_RS08880	COG1216	Glycosyl transferase, family 2
AO080_RS08890	COG0438	transferase activity, transferring glycosyl groups
AO080_RS08895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AO080_RS08900	COG0489	protein tyrosine kinase activity
AO080_RS08915	COG0233	cytoplasmic translational termination
AO080_RS08925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AO080_RS08930	COG0052	Belongs to the universal ribosomal protein uS2 family
AO080_RS08935	COG2827	Endonuclease containing a URI domain
AO080_RS08940	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AO080_RS08945	COG0204	Acyl-transferase
AO080_RS08950	COG0791	NLP P60 protein
AO080_RS08950	COG3883	PFAM NLP P60 protein
AO080_RS08965	COG3763	UPF0154 protein
AO080_RS08970	COG4224	UPF0291 protein
AO080_RS08975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AO080_RS08995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AO080_RS08995	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AO080_RS09000	COG1234	tRNA 3'-trailer cleavage
AO080_RS09015	COG0484	heat shock protein binding
AO080_RS09020	COG0443	Heat shock 70 kDa protein
AO080_RS09030	COG1420	regulation of RNA biosynthetic process
AO080_RS09060	COG1216	Glycosyl transferase, family 2
AO080_RS09070	COG0463	Glycosyl transferase, family 2
AO080_RS09080	COG1705	Flagellar rod assembly protein muramidase FlgJ
AO080_RS09095	COG0562	UDP-galactopyranose mutase
AO080_RS09125	COG0024	Methionine aminopeptidase
AO080_RS09150	COG1388	LysM domain
AO080_RS09150	COG1705	Flagellar rod assembly protein muramidase FlgJ
AO080_RS09170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AO080_RS09180	COG1682	transport, permease protein
AO080_RS09185	COG1134	teichoic acid transport
AO080_RS09185	COG1388	LysM domain
AO080_RS09190	COG1063	alcohol dehydrogenase
AO080_RS09195	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AO080_RS09200	COG3475	LICD family
AO080_RS09220	COG0463	Glycosyl transferase, family 2
AO080_RS09225	COG2246	polysaccharide biosynthetic process
AO080_RS09230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AO080_RS09240	COG2801	Transposase and inactivated derivatives
AO080_RS09265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AO080_RS09380	COG0463	Glycosyl transferase, family 2
AO080_RS09395	COG3706	GGDEF domain
AO080_RS09445	COG2309	aminopeptidase activity
AO080_RS09460	COG0564	pseudouridine synthase activity
AO080_RS09465	COG1278	Cold shock
AO080_RS09475	COG2814	Major facilitator Superfamily
AO080_RS09480	COG0741	lytic transglycosylase activity
AO080_RS09490	COG3973	AAA domain
AO080_RS09500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AO080_RS09505	COG1546	Belongs to the CinA family
AO080_RS09505	COG1058	Belongs to the CinA family
AO080_RS09510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AO080_RS09515	COG1426	Protein conserved in bacteria
AO080_RS09520	COG0612	Peptidase, M16
AO080_RS09525	COG0612	Peptidase, M16
AO080_RS09560	COG4717	serine-type aminopeptidase activity
AO080_RS09570	COG3679	Belongs to the UPF0342 family
AO080_RS09575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AO080_RS09580	COG1438	arginine binding
AO080_RS09605	COG0018	arginyl-trna synthetase
AO080_RS09620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AO080_RS09630	COG1121	(ABC) transporter
AO080_RS09650	COG1597	lipid kinase activity
AO080_RS09655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AO080_RS09660	COG0154	amidase activity
AO080_RS09665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AO080_RS09670	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AO080_RS09670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AO080_RS09695	COG1695	Transcriptional regulator
AO080_RS09705	COG1914	H( )-stimulated, divalent metal cation uptake system
AO080_RS09725	COG0667	Aldo Keto reductase
AO080_RS09730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AO080_RS09735	COG4721	ABC-type cobalt transport system, permease component
AO080_RS09740	COG1122	ATPase activity
AO080_RS09755	COG0710	3-dehydroquinate dehydratase activity
AO080_RS09760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AO080_RS09765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AO080_RS09770	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AO080_RS09775	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AO080_RS09780	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AO080_RS09785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AO080_RS09800	COG4684	Psort location CytoplasmicMembrane, score
AO080_RS09805	COG0436	Aminotransferase
AO080_RS09825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AO080_RS09830	COG0436	Aminotransferase
AO080_RS09835	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AO080_RS09840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AO080_RS09850	COG2171	N-acyltransferase activity
AO080_RS09860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AO080_RS09865	COG0527	aspartate kinase activity
AO080_RS09875	COG1609	Transcriptional regulator
AO080_RS09880	COG0083	homoserine kinase activity
AO080_RS09895	COG1321	iron dependent repressor
AO080_RS09925	COG0513	Belongs to the DEAD box helicase family
AO080_RS09930	COG0673	inositol 2-dehydrogenase activity
AO080_RS09935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AO080_RS09950	COG2801	Transposase and inactivated derivatives
AO080_RS09960	COG0501	Belongs to the peptidase M48B family
AO080_RS09965	COG1704	LemA family
AO080_RS09975	COG4115	mRNA cleavage
AO080_RS09980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AO080_RS09995	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AO080_RS10005	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AO080_RS10010	COG0439	Biotin carboxylase
AO080_RS10025	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AO080_RS10030	COG1028	Short-chain dehydrogenase reductase Sdr
AO080_RS10035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AO080_RS10040	COG2070	2-Nitropropane dioxygenase
AO080_RS10045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AO080_RS10050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AO080_RS10055	COG1846	Transcriptional regulator
AO080_RS10060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AO080_RS10070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AO080_RS10075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AO080_RS10085	COG0505	Belongs to the CarA family
AO080_RS10095	COG0564	pseudouridine synthase activity
AO080_RS10105	COG0328	RNA-DNA hybrid ribonuclease activity
AO080_RS10110	COG1757	Na H antiporter
AO080_RS10115	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AO080_RS10120	COG1113	amino acid transport
AO080_RS10165	COG2801	Transposase and inactivated derivatives
AO080_RS10170	COG1396	sequence-specific DNA binding
AO080_RS10190	COG4974	Belongs to the 'phage' integrase family
AO080_RS10205	COG0656	L-ascorbic acid biosynthetic process
AO080_RS10215	COG1012	belongs to the aldehyde dehydrogenase family
AO080_RS10215	COG1454	alcohol dehydrogenase
AO080_RS10220	COG0105	UTP biosynthetic process
AO080_RS10230	COG0583	DNA-binding transcription factor activity
AO080_RS10235	COG0126	phosphoglycerate kinase activity
AO080_RS10285	COG0588	phosphoglycerate mutase activity
AO080_RS10295	COG3716	PTS system mannose fructose sorbose family IID component
AO080_RS10300	COG3715	PTS system
AO080_RS10315	COG1397	ADP-ribosylglycohydrolase
AO080_RS10380	COG1368	sulfuric ester hydrolase activity
AO080_RS10395	COG0438	transferase activity, transferring glycosyl groups
AO080_RS10400	COG0438	transferase activity, transferring glycosyl groups
AO080_RS10405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AO080_RS10410	COG0284	orotidine-5'-phosphate decarboxylase activity
AO080_RS10415	COG0167	dihydroorotate dehydrogenase activity
AO080_RS10420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AO080_RS10425	COG0505	Belongs to the CarA family
AO080_RS10430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AO080_RS10435	COG0540	Belongs to the ATCase OTCase family
AO080_RS10455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AO080_RS10460	COG4856	YbbR-like protein
AO080_RS10475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AO080_RS10490	COG0802	atpase or kinase
AO080_RS10495	COG0280	phosphate acetyltransferase
AO080_RS10500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AO080_RS10510	COG2076	Multidrug Resistance protein
AO080_RS10515	COG2076	Multidrug Resistance protein
AO080_RS10525	COG0765	amino acid transport
AO080_RS10530	COG2814	Major facilitator Superfamily
AO080_RS10545	COG0557	exoribonuclease II activity
AO080_RS10555	COG2814	Major facilitator Superfamily
AO080_RS10560	COG0154	amidase activity
AO080_RS10580	COG2801	Transposase and inactivated derivatives
AO080_RS10590	COG0149	triose-phosphate isomerase activity
AO080_RS10595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AO080_RS10600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AO080_RS10610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AO080_RS10615	COG0492	ferredoxin-NADP+ reductase activity
AO080_RS10640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AO080_RS10645	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AO080_RS10650	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AO080_RS10655	COG1950	PFAM Membrane protein of
AO080_RS10665	COG0589	response to stress
AO080_RS10675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AO080_RS10685	COG1177	transmembrane transport
AO080_RS10695	COG3842	ATPase activity
AO080_RS10705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AO080_RS10710	COG0049	tRNA binding
AO080_RS10715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AO080_RS10725	COG4608	Belongs to the ABC transporter superfamily
AO080_RS10730	COG0444	Belongs to the ABC transporter superfamily
AO080_RS10735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AO080_RS10740	COG0601	transmembrane transport
AO080_RS10750	COG0460	homoserine dehydrogenase
AO080_RS10755	COG0626	cystathionine gamma-synthase activity
AO080_RS10760	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AO080_RS10770	COG1744	ABC transporter substrate-binding protein PnrA-like
AO080_RS10775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AO080_RS10780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AO080_RS10795	COG1302	Protein conserved in bacteria
AO080_RS10800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AO080_RS10810	COG2017	converts alpha-aldose to the beta-anomer
AO080_RS10820	COG4975	Glucose uptake
AO080_RS10825	COG3850	Histidine kinase
AO080_RS10825	COG5002	protein histidine kinase activity
AO080_RS10830	COG0745	RESPONSE REGULATOR receiver
AO080_RS10835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AO080_RS10840	COG0402	S-adenosylhomocysteine deaminase activity
AO080_RS10845	COG0673	inositol 2-dehydrogenase activity
AO080_RS10850	COG0741	lytic transglycosylase activity
AO080_RS10870	COG0668	transmembrane transport
AO080_RS10880	COG1126	abc transporter atp-binding protein
AO080_RS11005	COG0516	GMP reductase activity
AO080_RS11035	COG2801	Transposase and inactivated derivatives
AO080_RS11055	COG0738	Major facilitator superfamily
AO080_RS11060	COG1869	D-ribose catabolic process
AO080_RS11085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AO080_RS11100	COG1609	Transcriptional regulator
AO080_RS11135	COG2223	nitrite transmembrane transporter activity
AO080_RS11145	COG0318	PFAM AMP-dependent synthetase and ligase
AO080_RS11155	COG1116	anion transmembrane transporter activity
AO080_RS11160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AO080_RS11170	COG0285	dihydrofolate synthase activity
AO080_RS11175	COG0302	gtp cyclohydrolase
AO080_RS11180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AO080_RS11180	COG0302	gtp cyclohydrolase
AO080_RS11195	COG0561	phosphatase activity
AO080_RS11210	COG1464	Belongs to the NlpA lipoprotein family
AO080_RS11215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AO080_RS11220	COG0800	Aldolase
AO080_RS11225	COG1904	glucuronate isomerase
AO080_RS11235	COG0246	Mannitol dehydrogenase
AO080_RS11250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AO080_RS11265	COG1609	Transcriptional regulator
AO080_RS11295	COG0577	efflux transmembrane transporter activity
AO080_RS11300	COG1136	(ABC) transporter
AO080_RS11305	COG3759	membrane
AO080_RS11325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AO080_RS11330	COG2235	arginine
AO080_RS11340	COG2217	Heavy metal translocating P-type atpase
AO080_RS11410	COG0438	transferase activity, transferring glycosyl groups
AO080_RS11465	COG2814	Major facilitator Superfamily
AO080_RS11470	COG2217	Heavy metal translocating P-type atpase
AO080_RS11490	COG1309	transcriptional regulator
AO080_RS11510	COG3711	transcriptional antiterminator
AO080_RS11515	COG2723	6-phospho-beta-galactosidase activity
AO080_RS11520	COG1940	carbohydrate kinase activity
AO080_RS11540	COG2183	response to ionizing radiation
AO080_RS11550	COG2873	o-acetylhomoserine
AO080_RS11555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AO080_RS11560	COG1040	competence protein
AO080_RS11640	COG2176	DNA-directed DNA polymerase activity
AO080_RS11645	COG0442	prolyl-tRNA aminoacylation
AO080_RS11650	COG0750	zinc metalloprotease
AO080_RS11655	COG4589	Belongs to the CDS family
AO080_RS11660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AO080_RS11665	COG0561	phosphatase activity
AO080_RS11670	COG2246	polysaccharide biosynthetic process
AO080_RS11695	COG1811	Na channel or pump
AO080_RS11700	COG1979	alcohol dehydrogenase
AO080_RS11710	COG1174	glycine betaine transport
AO080_RS11750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AO080_RS11750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AO080_RS11795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AO080_RS11795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AO080_RS11895	COG0484	heat shock protein binding
AO080_RS11920	COG2252	PERMEase
AO080_RS12150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AO080_RS12150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AO080_RS12205	COG0477	Major facilitator Superfamily