locus-tag	class	description
CHR48_RS00025	COG1126	abc transporter atp-binding protein
CHR48_RS00035	COG0668	transmembrane transport
CHR48_RS00055	COG0741	lytic transglycosylase activity
CHR48_RS00065	COG0402	S-adenosylhomocysteine deaminase activity
CHR48_RS00070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CHR48_RS00075	COG0745	RESPONSE REGULATOR receiver
CHR48_RS00080	COG3850	Histidine kinase
CHR48_RS00080	COG5002	protein histidine kinase activity
CHR48_RS00085	COG4975	Glucose uptake
CHR48_RS00095	COG2017	converts alpha-aldose to the beta-anomer
CHR48_RS00105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CHR48_RS00110	COG1302	Protein conserved in bacteria
CHR48_RS00125	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CHR48_RS00130	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CHR48_RS00135	COG1744	ABC transporter substrate-binding protein PnrA-like
CHR48_RS00145	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CHR48_RS00150	COG0626	cystathionine gamma-synthase activity
CHR48_RS00155	COG0460	homoserine dehydrogenase
CHR48_RS00165	COG0601	transmembrane transport
CHR48_RS00170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHR48_RS00175	COG0444	Belongs to the ABC transporter superfamily
CHR48_RS00180	COG4608	Belongs to the ABC transporter superfamily
CHR48_RS00185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CHR48_RS00190	COG0049	tRNA binding
CHR48_RS00195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CHR48_RS00205	COG3842	ATPase activity
CHR48_RS00215	COG1177	transmembrane transport
CHR48_RS00225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CHR48_RS00235	COG0589	response to stress
CHR48_RS00245	COG1950	PFAM Membrane protein of
CHR48_RS00250	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CHR48_RS00255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CHR48_RS00260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CHR48_RS00285	COG0492	ferredoxin-NADP+ reductase activity
CHR48_RS00290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CHR48_RS00300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHR48_RS00305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CHR48_RS00310	COG0149	triose-phosphate isomerase activity
CHR48_RS00330	COG0154	amidase activity
CHR48_RS00335	COG2814	Major facilitator Superfamily
CHR48_RS00345	COG0557	exoribonuclease II activity
CHR48_RS00360	COG2814	Major facilitator Superfamily
CHR48_RS00365	COG0765	amino acid transport
CHR48_RS00370	COG1126	abc transporter atp-binding protein
CHR48_RS00375	COG2076	Multidrug Resistance protein
CHR48_RS00380	COG2076	Multidrug Resistance protein
CHR48_RS00390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CHR48_RS00395	COG0280	phosphate acetyltransferase
CHR48_RS00400	COG0802	atpase or kinase
CHR48_RS00415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CHR48_RS00430	COG4856	YbbR-like protein
CHR48_RS00435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CHR48_RS00455	COG0540	Belongs to the ATCase OTCase family
CHR48_RS00460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CHR48_RS00465	COG0505	Belongs to the CarA family
CHR48_RS00470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CHR48_RS00475	COG0167	dihydroorotate dehydrogenase activity
CHR48_RS00480	COG0284	orotidine-5'-phosphate decarboxylase activity
CHR48_RS00485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CHR48_RS00490	COG0438	transferase activity, transferring glycosyl groups
CHR48_RS00495	COG0438	transferase activity, transferring glycosyl groups
CHR48_RS00510	COG1368	sulfuric ester hydrolase activity
CHR48_RS00570	COG1397	ADP-ribosylglycohydrolase
CHR48_RS00585	COG3715	PTS system
CHR48_RS00590	COG3716	PTS system mannose fructose sorbose family IID component
CHR48_RS00600	COG0588	phosphoglycerate mutase activity
CHR48_RS00650	COG0126	phosphoglycerate kinase activity
CHR48_RS00655	COG0583	DNA-binding transcription factor activity
CHR48_RS00665	COG0105	UTP biosynthetic process
CHR48_RS00670	COG1454	alcohol dehydrogenase
CHR48_RS00670	COG1012	belongs to the aldehyde dehydrogenase family
CHR48_RS00680	COG0656	L-ascorbic acid biosynthetic process
CHR48_RS00705	COG1113	amino acid transport
CHR48_RS00710	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CHR48_RS00715	COG1757	Na H antiporter
CHR48_RS00720	COG0328	RNA-DNA hybrid ribonuclease activity
CHR48_RS00730	COG0564	pseudouridine synthase activity
CHR48_RS00740	COG0505	Belongs to the CarA family
CHR48_RS00750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CHR48_RS00755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CHR48_RS00765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CHR48_RS00770	COG1846	Transcriptional regulator
CHR48_RS00775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CHR48_RS00780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CHR48_RS00785	COG2070	2-Nitropropane dioxygenase
CHR48_RS00790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CHR48_RS00795	COG1028	Short-chain dehydrogenase reductase Sdr
CHR48_RS00800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CHR48_RS00815	COG0439	Biotin carboxylase
CHR48_RS00820	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CHR48_RS00830	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CHR48_RS00845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CHR48_RS00850	COG4115	mRNA cleavage
CHR48_RS00860	COG1704	LemA family
CHR48_RS00865	COG0501	Belongs to the peptidase M48B family
CHR48_RS00875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CHR48_RS00880	COG0673	inositol 2-dehydrogenase activity
CHR48_RS00885	COG0513	Belongs to the DEAD box helicase family
CHR48_RS00905	COG3764	Sortase (surface protein transpeptidase)
CHR48_RS00910	COG1321	iron dependent repressor
CHR48_RS00925	COG0083	homoserine kinase activity
CHR48_RS00930	COG1609	Transcriptional regulator
CHR48_RS00940	COG0527	aspartate kinase activity
CHR48_RS00945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CHR48_RS00955	COG2171	N-acyltransferase activity
CHR48_RS00965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CHR48_RS00970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CHR48_RS00975	COG0436	Aminotransferase
CHR48_RS00980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CHR48_RS00985	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CHR48_RS01020	COG1396	sequence-specific DNA binding
CHR48_RS01160	COG1783	phage Terminase large subunit
CHR48_RS01175	COG2801	Transposase and inactivated derivatives
CHR48_RS01195	COG0436	Aminotransferase
CHR48_RS01200	COG4684	Psort location CytoplasmicMembrane, score
CHR48_RS01215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CHR48_RS01220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CHR48_RS01225	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CHR48_RS01230	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CHR48_RS01235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CHR48_RS01240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CHR48_RS01245	COG0710	3-dehydroquinate dehydratase activity
CHR48_RS01260	COG0758	DNA mediated transformation
CHR48_RS01275	COG1122	ATPase activity
CHR48_RS01280	COG4721	ABC-type cobalt transport system, permease component
CHR48_RS01285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CHR48_RS01290	COG0667	Aldo Keto reductase
CHR48_RS01310	COG1914	H( )-stimulated, divalent metal cation uptake system
CHR48_RS01320	COG1695	Transcriptional regulator
CHR48_RS01335	COG2936	dipeptidyl-peptidase activity
CHR48_RS01345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CHR48_RS01345	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CHR48_RS01350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CHR48_RS01355	COG0154	amidase activity
CHR48_RS01360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CHR48_RS01365	COG1597	lipid kinase activity
CHR48_RS01385	COG1121	(ABC) transporter
CHR48_RS01395	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CHR48_RS01410	COG0018	arginyl-trna synthetase
CHR48_RS01435	COG1959	2 iron, 2 sulfur cluster binding
CHR48_RS01465	COG1438	arginine binding
CHR48_RS01470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CHR48_RS01475	COG3679	Belongs to the UPF0342 family
CHR48_RS01490	COG4717	serine-type aminopeptidase activity
CHR48_RS01510	COG0028	Belongs to the TPP enzyme family
CHR48_RS01525	COG0612	Peptidase, M16
CHR48_RS01530	COG0612	Peptidase, M16
CHR48_RS01535	COG1426	Protein conserved in bacteria
CHR48_RS01540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CHR48_RS01545	COG1058	Belongs to the CinA family
CHR48_RS01545	COG1546	Belongs to the CinA family
CHR48_RS01550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CHR48_RS01560	COG3973	AAA domain
CHR48_RS01570	COG0741	lytic transglycosylase activity
CHR48_RS01575	COG2814	Major facilitator Superfamily
CHR48_RS01585	COG1278	Cold shock
CHR48_RS01590	COG0564	pseudouridine synthase activity
CHR48_RS01605	COG2309	aminopeptidase activity
CHR48_RS01640	COG2801	Transposase and inactivated derivatives
CHR48_RS01670	COG0024	Methionine aminopeptidase
CHR48_RS01695	COG0562	UDP-galactopyranose mutase
CHR48_RS01710	COG1705	Flagellar rod assembly protein muramidase FlgJ
CHR48_RS01720	COG0463	Glycosyl transferase, family 2
CHR48_RS01730	COG1216	Glycosyl transferase, family 2
CHR48_RS01760	COG1420	regulation of RNA biosynthetic process
CHR48_RS01770	COG0443	Heat shock 70 kDa protein
CHR48_RS01775	COG0484	heat shock protein binding
CHR48_RS01790	COG1234	tRNA 3'-trailer cleavage
CHR48_RS01795	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CHR48_RS01795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CHR48_RS01815	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CHR48_RS01820	COG4224	UPF0291 protein
CHR48_RS01825	COG3763	UPF0154 protein
CHR48_RS01840	COG0791	NLP P60 protein
CHR48_RS01840	COG3883	PFAM NLP P60 protein
CHR48_RS01845	COG0204	Acyl-transferase
CHR48_RS01850	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CHR48_RS01855	COG2827	Endonuclease containing a URI domain
CHR48_RS01860	COG0052	Belongs to the universal ribosomal protein uS2 family
CHR48_RS01865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CHR48_RS01875	COG0233	cytoplasmic translational termination
CHR48_RS01890	COG0489	protein tyrosine kinase activity
CHR48_RS01895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CHR48_RS01900	COG0438	transferase activity, transferring glycosyl groups
CHR48_RS01910	COG1216	Glycosyl transferase, family 2
CHR48_RS01920	COG1216	Glycosyl transferase, family 2
CHR48_RS01925	COG1316	TRANSCRIPTIONal
CHR48_RS01930	COG5263	repeat protein
CHR48_RS01930	COG0366	Alpha amylase catalytic
CHR48_RS01940	COG0004	ammonium transporteR
CHR48_RS01945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CHR48_RS01950	COG1266	CAAX protease self-immunity
CHR48_RS01970	COG0617	tRNA 3'-terminal CCA addition
CHR48_RS01975	COG0488	(ABC) transporter
CHR48_RS01980	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CHR48_RS01990	COG0587	DNA-directed DNA polymerase activity
CHR48_RS01995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CHR48_RS02000	COG1490	D-aminoacyl-tRNA deacylase activity
CHR48_RS02010	COG0475	glutathione-regulated potassium exporter activity
CHR48_RS02020	COG2996	Protein conserved in bacteria
CHR48_RS02035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CHR48_RS02040	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CHR48_RS02045	COG1187	pseudouridine synthase activity
CHR48_RS02060	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CHR48_RS02070	COG0514	ATP-dependent DNA helicase (RecQ)
CHR48_RS02080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CHR48_RS02085	COG0539	negative regulation of cytoplasmic translation
CHR48_RS02090	COG1160	GTP binding
CHR48_RS02100	COG0351	phosphomethylpyrimidine kinase
CHR48_RS02105	COG4720	Psort location CytoplasmicMembrane, score
CHR48_RS02110	COG2807	transmembrane transport
CHR48_RS02120	COG0420	3'-5' exonuclease activity
CHR48_RS02125	COG0419	ATPase involved in DNA repair
CHR48_RS02160	COG0457	Tetratricopeptide repeat
CHR48_RS02165	COG0071	Belongs to the small heat shock protein (HSP20) family
CHR48_RS02170	COG2384	SAM-dependent methyltransferase
CHR48_RS02175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CHR48_RS02205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CHR48_RS02210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CHR48_RS02220	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CHR48_RS02230	COG0577	efflux transmembrane transporter activity
CHR48_RS02235	COG1136	(ABC) transporter
CHR48_RS02250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CHR48_RS02260	COG0281	malic enzyme
CHR48_RS02265	COG0583	DNA-binding transcription factor activity
CHR48_RS02270	COG4221	oxidoreductase activity
CHR48_RS02275	COG0531	amino acid
CHR48_RS02285	COG4708	membrane
CHR48_RS02290	COG1028	Short-chain dehydrogenase reductase Sdr
CHR48_RS02320	COG0481	GTPase activity
CHR48_RS02330	COG0531	amino acid
CHR48_RS02350	COG2723	6-phospho-beta-galactosidase activity
CHR48_RS02360	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CHR48_RS02370	COG0306	phosphate transporter
CHR48_RS02380	COG1609	Transcriptional regulator
CHR48_RS02390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CHR48_RS02390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CHR48_RS02390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CHR48_RS02395	COG1105	Belongs to the carbohydrate kinase PfkB family
CHR48_RS02400	COG1349	DNA-binding transcription factor activity
CHR48_RS02405	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CHR48_RS02410	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHR48_RS02440	COG1397	ADP-ribosylglycohydrolase
CHR48_RS02445	COG1719	4-vinyl reductase, 4VR
CHR48_RS02450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CHR48_RS02460	COG1131	(ABC) transporter
CHR48_RS02465	COG0537	adenosine 5'-monophosphoramidase activity
CHR48_RS02475	COG0363	glucosamine-6-phosphate deaminase activity
CHR48_RS02480	COG3104	oligopeptide transport
CHR48_RS02490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CHR48_RS02495	COG0439	Biotin carboxylase
CHR48_RS02505	COG0556	nucleotide-excision repair
CHR48_RS02525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CHR48_RS02535	COG0116	Belongs to the methyltransferase superfamily
CHR48_RS02545	COG3599	regulation of cell shape
CHR48_RS02550	COG4474	Belongs to the UPF0398 family
CHR48_RS02555	COG3331	DNA recombination
CHR48_RS02565	COG3935	DnaD domain protein
CHR48_RS02570	COG0017	Asparaginyl-tRNA synthetase
CHR48_RS02580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CHR48_RS02580	COG1199	ATP-dependent helicase activity
CHR48_RS02600	COG1304	FMN binding
CHR48_RS02610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR48_RS02615	COG1028	Short-chain dehydrogenase reductase Sdr
CHR48_RS02620	COG0706	membrane insertase activity
CHR48_RS02645	COG3942	CHAP domain
CHR48_RS02645	COG1705	Flagellar rod assembly protein muramidase FlgJ
CHR48_RS02655	COG5002	protein histidine kinase activity
CHR48_RS02660	COG0745	RESPONSE REGULATOR receiver
CHR48_RS02675	COG1484	DNA-dependent DNA replication
CHR48_RS02685	COG0237	dephospho-CoA kinase activity
CHR48_RS02690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CHR48_RS02695	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHR48_RS02695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CHR48_RS02700	COG0670	Belongs to the BI1 family
CHR48_RS02705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CHR48_RS02715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHR48_RS02720	COG1363	Peptidase, m42
CHR48_RS02725	COG0572	uridine kinase
CHR48_RS02730	COG5002	protein histidine kinase activity
CHR48_RS02735	COG0745	RESPONSE REGULATOR receiver
CHR48_RS02765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CHR48_RS02770	COG0358	DNA primase activity
CHR48_RS02775	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CHR48_RS02780	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CHR48_RS02790	COG0477	Major facilitator Superfamily
CHR48_RS02795	COG3480	Lon protease (S16) C-terminal proteolytic domain
CHR48_RS02800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CHR48_RS02805	COG0742	ribosomal rna small subunit methyltransferase
CHR48_RS02810	COG4471	UPF0298 protein
CHR48_RS02815	COG0772	Belongs to the SEDS family
CHR48_RS02820	COG1217	gtp-binding protein TYPA
CHR48_RS02825	COG0483	inositol monophosphate 1-phosphatase activity
CHR48_RS02830	COG4476	Belongs to the UPF0223 family
CHR48_RS02835	COG0242	peptide deformylase activity
CHR48_RS02850	COG5503	Protein of unknown function (DUF1447)
CHR48_RS02870	COG1011	Hydrolase
CHR48_RS02875	COG1597	lipid kinase activity
CHR48_RS02880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHR48_RS02885	COG1464	Belongs to the NlpA lipoprotein family
CHR48_RS02890	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHR48_RS02900	COG3448	diguanylate cyclase activity
CHR48_RS02900	COG4175	Glycine betaine
CHR48_RS02920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CHR48_RS02930	COG4974	Belongs to the 'phage' integrase family
CHR48_RS02935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CHR48_RS02940	COG0758	DNA mediated transformation
CHR48_RS02945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CHR48_RS02955	COG4479	Belongs to the UPF0346 family
CHR48_RS02965	COG2755	lipolytic protein G-D-S-L family
CHR48_RS02970	COG1307	EDD domain protein, DegV family
CHR48_RS02975	COG1307	EDD domain protein, DegV family
CHR48_RS02980	COG2270	Major facilitator Superfamily
CHR48_RS02995	COG3142	Participates in the control of copper homeostasis
CHR48_RS03000	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CHR48_RS03005	COG0196	riboflavin kinase activity
CHR48_RS03015	COG1252	NADH dehydrogenase
CHR48_RS03020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CHR48_RS03025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CHR48_RS03030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CHR48_RS03040	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CHR48_RS03045	COG0195	Participates in both transcription termination and antitermination
CHR48_RS03050	COG0779	Required for maturation of 30S ribosomal subunits
CHR48_RS03065	COG1304	FMN binding
CHR48_RS03085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CHR48_RS03090	COG0738	Major facilitator superfamily
CHR48_RS03100	COG0287	Prephenate dehydrogenase
CHR48_RS03105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CHR48_RS03110	COG4684	Psort location CytoplasmicMembrane, score
CHR48_RS03115	COG1621	beta-fructofuranosidase activity
CHR48_RS03125	COG0384	phenazine biosynthesis protein PhzF
CHR48_RS03180	COG1846	Transcriptional regulator
CHR48_RS03190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CHR48_RS03195	COG0656	L-ascorbic acid biosynthetic process
CHR48_RS03205	COG0583	DNA-binding transcription factor activity
CHR48_RS03240	COG0488	(ABC) transporter
CHR48_RS03245	COG0488	(ABC) transporter
CHR48_RS03260	COG2814	Major facilitator Superfamily
CHR48_RS03265	COG2239	Acts as a magnesium transporter
CHR48_RS03270	COG0564	pseudouridine synthase activity
CHR48_RS03275	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CHR48_RS03280	COG2357	RelA SpoT domain protein
CHR48_RS03295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CHR48_RS03300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CHR48_RS03380	COG1940	carbohydrate kinase activity
CHR48_RS03390	COG1028	Short-chain dehydrogenase reductase Sdr
CHR48_RS03410	COG0352	thiamine-phosphate diphosphorylase activity
CHR48_RS03415	COG0351	phosphomethylpyrimidine kinase
CHR48_RS03420	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CHR48_RS03430	COG1464	Belongs to the NlpA lipoprotein family
CHR48_RS03445	COG0436	Aminotransferase
CHR48_RS03450	COG0277	FAD linked oxidase domain protein
CHR48_RS03480	COG2801	Transposase and inactivated derivatives
CHR48_RS03535	COG2801	Transposase and inactivated derivatives
CHR48_RS03555	COG0604	alcohol dehydrogenase
CHR48_RS03555	COG3321	synthase
CHR48_RS03560	COG0248	Ppx GppA phosphatase
CHR48_RS03565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CHR48_RS03610	COG3201	nicotinamide mononucleotide transporter
CHR48_RS03615	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CHR48_RS03635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CHR48_RS03650	COG1473	amidohydrolase
CHR48_RS03660	COG3527	Alpha-acetolactate decarboxylase
CHR48_RS03665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CHR48_RS03670	COG0187	DNA topoisomerase II activity
CHR48_RS03675	COG3118	belongs to the thioredoxin family
CHR48_RS03695	COG1193	negative regulation of DNA recombination
CHR48_RS03715	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CHR48_RS03720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CHR48_RS03725	COG0544	peptidyl-prolyl cis-trans isomerase activity
CHR48_RS03750	COG0268	Binds directly to 16S ribosomal RNA
CHR48_RS03755	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CHR48_RS03760	COG1466	dna polymerase III delta subunit
CHR48_RS03765	COG0658	competence protein
CHR48_RS03765	COG2333	competence protein COMEC
CHR48_RS03775	COG3906	Belongs to the UPF0473 family
CHR48_RS03795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CHR48_RS03800	COG1929	Belongs to the glycerate kinase type-1 family
CHR48_RS03810	COG0513	Belongs to the DEAD box helicase family
CHR48_RS03815	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CHR48_RS03825	COG1862	Preprotein translocase
CHR48_RS03830	COG0343	queuine tRNA-ribosyltransferase activity
CHR48_RS03865	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CHR48_RS03870	COG2255	four-way junction helicase activity
CHR48_RS03875	COG0632	four-way junction helicase activity
CHR48_RS03885	COG0516	GMP reductase activity
CHR48_RS03885	COG0517	IMP dehydrogenase activity
CHR48_RS03890	COG0517	IMP dehydrogenase activity
CHR48_RS03890	COG0516	GMP reductase activity
CHR48_RS03905	COG1739	Uncharacterized protein family UPF0029
CHR48_RS03910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CHR48_RS03915	COG0322	excinuclease ABC activity
CHR48_RS03925	COG1668	transmembrane transport
CHR48_RS03930	COG4152	abc transporter atp-binding protein
CHR48_RS03940	COG1674	ftsk spoiiie
CHR48_RS03950	COG0628	permease
CHR48_RS03955	COG2706	6-phosphogluconolactonase activity
CHR48_RS03975	COG0751	glycine-tRNA ligase activity
CHR48_RS03980	COG0752	glycyl-tRNA synthetase alpha subunit
CHR48_RS03990	COG1381	Involved in DNA repair and RecF pathway recombination
CHR48_RS03995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CHR48_RS04000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CHR48_RS04005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CHR48_RS04010	COG1702	phosphate starvation-inducible protein PhoH
CHR48_RS04015	COG1610	YqeY-like protein
CHR48_RS04020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CHR48_RS04025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR48_RS04035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CHR48_RS04040	COG0124	histidyl-tRNA synthetase
CHR48_RS04045	COG0860	N-Acetylmuramoyl-L-alanine amidase
CHR48_RS04060	COG3425	synthase
CHR48_RS04065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CHR48_RS04135	COG0006	proline dipeptidase activity
CHR48_RS04140	COG1609	Transcriptional regulator
CHR48_RS04155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CHR48_RS04160	COG1164	Oligoendopeptidase f
CHR48_RS04170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CHR48_RS04175	COG2723	6-phospho-beta-galactosidase activity
CHR48_RS04180	COG1447	Phosphotransferase system cellobiose-specific component IIA
CHR48_RS04185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CHR48_RS04190	COG2723	6-phospho-beta-galactosidase activity
CHR48_RS04195	COG4862	establishment of competence for transformation
CHR48_RS04200	COG1393	Belongs to the ArsC family
CHR48_RS04205	COG3853	Toxic anion resistance protein (TelA)
CHR48_RS04270	COG0561	phosphatase activity
CHR48_RS04275	COG1970	mechanosensitive ion channel activity
CHR48_RS04280	COG1428	Deoxynucleoside kinase
CHR48_RS04290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CHR48_RS04295	COG1942	4-Oxalocrotonate Tautomerase
CHR48_RS04300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR48_RS04310	COG0335	large ribosomal subunit rRNA binding
CHR48_RS04315	COG0336	Belongs to the RNA methyltransferase TrmD family
CHR48_RS04320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CHR48_RS04325	COG0588	phosphoglycerate mutase activity
CHR48_RS04340	COG0228	four-way junction DNA binding
CHR48_RS04355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CHR48_RS04360	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CHR48_RS04365	COG0552	protein localization to endoplasmic reticulum
CHR48_RS04370	COG1196	nuclear chromosome segregation
CHR48_RS04375	COG0571	ribonuclease III activity
CHR48_RS04380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CHR48_RS04385	COG0416	fatty acid biosynthetic process
CHR48_RS04390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CHR48_RS04400	COG0438	transferase activity, transferring glycosyl groups
CHR48_RS04415	COG1461	Dihydroxyacetone kinase
CHR48_RS04425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CHR48_RS04435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CHR48_RS04440	COG1162	GTPase activity
CHR48_RS04445	COG2815	serine threonine protein kinase
CHR48_RS04445	COG0515	serine threonine protein kinase
CHR48_RS04450	COG0631	protein serine/threonine phosphatase activity
CHR48_RS04455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CHR48_RS04455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CHR48_RS04460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CHR48_RS04465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CHR48_RS04470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CHR48_RS04510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CHR48_RS04515	COG2252	PERMEase
CHR48_RS04520	COG0217	transcriptional regulatory protein
CHR48_RS04525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CHR48_RS04545	COG3599	regulation of cell shape
CHR48_RS04560	COG1799	cell septum assembly
CHR48_RS04570	COG0849	cell division
CHR48_RS04575	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CHR48_RS04580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CHR48_RS04585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CHR48_RS04590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CHR48_RS04595	COG0768	penicillin binding
CHR48_RS04605	COG0275	rRNA processing
CHR48_RS04610	COG2001	Belongs to the MraZ family
CHR48_RS04620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CHR48_RS04625	COG2264	protein methyltransferase activity
CHR48_RS04635	COG0833	amino acid
CHR48_RS04650	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHR48_RS04665	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CHR48_RS04670	COG0151	Belongs to the GarS family
CHR48_RS04675	COG0138	bifunctional purine biosynthesis protein purh
CHR48_RS04680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CHR48_RS04685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CHR48_RS04695	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CHR48_RS04710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CHR48_RS04715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CHR48_RS04720	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CHR48_RS04725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CHR48_RS04725	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CHR48_RS04730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHR48_RS04735	COG1126	abc transporter atp-binding protein
CHR48_RS04740	COG0765	amino acid transport
CHR48_RS04750	COG3338	carbonate dehydratase activity
CHR48_RS04760	COG1077	Cell shape determining protein MreB Mrl
CHR48_RS04765	COG2003	Belongs to the UPF0758 family
CHR48_RS04780	COG2190	(PTS) system
CHR48_RS04780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHR48_RS04780	COG1263	PTS System
CHR48_RS04785	COG1307	EDD domain protein, DegV family
CHR48_RS04790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CHR48_RS04795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CHR48_RS04800	COG0038	chloride channel
CHR48_RS04810	COG4120	Belongs to the binding-protein-dependent transport system permease family
CHR48_RS04820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHR48_RS04825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHR48_RS04830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CHR48_RS04850	COG0741	lytic transglycosylase activity
CHR48_RS04860	COG0400	carboxylic ester hydrolase activity
CHR48_RS04865	COG0346	lactoylglutathione lyase activity
CHR48_RS04870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CHR48_RS04880	COG0494	nUDIX hydrolase
CHR48_RS04885	COG1278	Cold shock
CHR48_RS04900	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CHR48_RS04905	COG1705	Flagellar rod assembly protein muramidase FlgJ
CHR48_RS04905	COG1388	LysM domain
CHR48_RS04910	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CHR48_RS04915	COG4988	ABC transporter
CHR48_RS04920	COG1294	oxidase, subunit
CHR48_RS04925	COG1271	oxidase subunit
CHR48_RS04930	COG4684	Psort location CytoplasmicMembrane, score
CHR48_RS05045	COG1098	S1 RNA binding domain
CHR48_RS05050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CHR48_RS05055	COG0586	Pfam SNARE associated Golgi protein
CHR48_RS05065	COG0194	GDP metabolic process
CHR48_RS05075	COG0497	DNA recombination
CHR48_RS05080	COG1438	arginine binding
CHR48_RS05085	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CHR48_RS05090	COG0142	geranyltranstransferase activity
CHR48_RS05100	COG1570	exodeoxyribonuclease VII activity
CHR48_RS05105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CHR48_RS05110	COG4720	Psort location CytoplasmicMembrane, score
CHR48_RS05125	COG1136	(ABC) transporter
CHR48_RS05130	COG0577	efflux transmembrane transporter activity
CHR48_RS05140	COG0776	regulation of translation
CHR48_RS05145	COG0363	glucosamine-6-phosphate deaminase activity
CHR48_RS05155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CHR48_RS05245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CHR48_RS05250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CHR48_RS05260	COG1323	Belongs to the UPF0348 family
CHR48_RS05265	COG2226	methyltransferase
CHR48_RS05270	COG0799	negative regulation of ribosome biogenesis
CHR48_RS05275	COG1713	HD superfamily hydrolase involved in NAD metabolism
CHR48_RS05280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CHR48_RS05290	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CHR48_RS05295	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CHR48_RS05300	COG1181	Belongs to the D-alanine--D-alanine ligase family
CHR48_RS05310	COG0531	amino acid
CHR48_RS05315	COG0459	protein refolding
CHR48_RS05320	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CHR48_RS05325	COG0488	(ABC) transporter
CHR48_RS05345	COG0285	dihydrofolate synthase activity
CHR48_RS05355	COG0525	valine-tRNA ligase activity
CHR48_RS05390	COG1272	protein, Hemolysin III
CHR48_RS05500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CHR48_RS05510	COG5506	Protein of unknown function (DUF1694)
CHR48_RS05520	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CHR48_RS05545	COG2137	regulation of response to DNA damage stimulus
CHR48_RS05550	COG0704	Plays a role in the regulation of phosphate uptake
CHR48_RS05555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CHR48_RS05560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CHR48_RS05565	COG0581	inorganic phosphate transmembrane transporter activity
CHR48_RS05570	COG0573	inorganic phosphate transmembrane transporter activity
CHR48_RS05595	COG0673	inositol 2-dehydrogenase activity
CHR48_RS05600	COG4166	transmembrane transport
CHR48_RS05605	COG0647	UMP catabolic process
CHR48_RS05610	COG4470	Protein conserved in bacteria
CHR48_RS05615	COG0737	Belongs to the 5'-nucleotidase family
CHR48_RS05635	COG4948	Mandelate Racemase Muconate Lactonizing
CHR48_RS05640	COG0596	Alpha beta hydrolase
CHR48_RS05645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CHR48_RS05655	COG0778	Nitroreductase
CHR48_RS05660	COG1132	(ABC) transporter
CHR48_RS05670	COG1472	Belongs to the glycosyl hydrolase 3 family
CHR48_RS05675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CHR48_RS05680	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CHR48_RS05705	COG0174	glutamine synthetase
CHR48_RS05710	COG0789	Transcriptional regulator
CHR48_RS05715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CHR48_RS05720	COG0584	glycerophosphoryl diester phosphodiesterase
CHR48_RS05740	COG3942	CHAP domain
CHR48_RS05745	COG5632	N-Acetylmuramoyl-L-alanine amidase
CHR48_RS05745	COG3409	Peptidoglycan-binding domain 1 protein
CHR48_RS05750	COG1940	carbohydrate kinase activity
CHR48_RS05765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CHR48_RS05770	COG0768	penicillin binding
CHR48_RS05780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CHR48_RS05785	COG0514	ATP-dependent DNA helicase (RecQ)
CHR48_RS05790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CHR48_RS05795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHR48_RS05795	COG0072	phenylalanine-tRNA ligase activity
CHR48_RS05800	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CHR48_RS05805	COG1733	regulation of RNA biosynthetic process
CHR48_RS05815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CHR48_RS05835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CHR48_RS05840	COG0653	protein targeting
CHR48_RS05850	COG4956	integral membrane protein (PIN domain superfamily)
CHR48_RS05860	COG0756	dUTP diphosphatase activity
CHR48_RS05870	COG0791	NLP P60 protein
CHR48_RS05875	COG1388	LysM domain
CHR48_RS05875	COG3942	CHAP domain
CHR48_RS05885	COG3527	Alpha-acetolactate decarboxylase
CHR48_RS05890	COG0028	Belongs to the TPP enzyme family
CHR48_RS05895	COG0039	L-malate dehydrogenase activity
CHR48_RS05915	COG1914	H( )-stimulated, divalent metal cation uptake system
CHR48_RS05925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHR48_RS05925	COG1263	PTS System
CHR48_RS05940	COG0740	serine-type endopeptidase activity
CHR48_RS05945	COG1481	regulation of sporulation
CHR48_RS05950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CHR48_RS05965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CHR48_RS05970	COG2814	Major facilitator Superfamily
CHR48_RS05980	COG0671	phosphoesterase, PA-phosphatase related
CHR48_RS05990	COG0366	Alpha amylase catalytic
CHR48_RS06005	COG1573	uracil-dna glycosylase
CHR48_RS06015	COG0028	Belongs to the TPP enzyme family
CHR48_RS06035	COG4221	oxidoreductase activity
CHR48_RS06045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CHR48_RS06050	COG0101	tRNA pseudouridine synthase activity
CHR48_RS06060	COG1122	ATPase activity
CHR48_RS06065	COG1122	ATPase activity
CHR48_RS06075	COG1252	NADH dehydrogenase
CHR48_RS06080	COG0803	Belongs to the bacterial solute-binding protein 9 family
CHR48_RS06085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CHR48_RS06090	COG1121	(ABC) transporter
CHR48_RS06100	COG0222	ribosome binding
CHR48_RS06105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CHR48_RS06110	COG0081	regulation of translation
CHR48_RS06115	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CHR48_RS06120	COG0250	Participates in transcription elongation, termination and antitermination
CHR48_RS06125	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CHR48_RS06140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CHR48_RS06145	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CHR48_RS06150	COG1854	S-ribosylhomocysteine lyase activity
CHR48_RS06155	COG1464	Belongs to the NlpA lipoprotein family
CHR48_RS06160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CHR48_RS06165	COG0626	cystathionine gamma-synthase activity
CHR48_RS06170	COG0215	cysteine-tRNA ligase activity
CHR48_RS06175	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CHR48_RS06180	COG0039	L-malate dehydrogenase activity
CHR48_RS06185	COG0471	metal ion transport
CHR48_RS06190	COG1053	succinate dehydrogenase
CHR48_RS06195	COG0114	fumarate hydratase activity
CHR48_RS06200	COG0583	DNA-binding transcription factor activity
CHR48_RS06225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CHR48_RS06240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CHR48_RS06265	COG0203	ribosomal protein L17
CHR48_RS06270	COG0202	RNA polymerase activity
CHR48_RS06275	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CHR48_RS06280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CHR48_RS06285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CHR48_RS06290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CHR48_RS06305	COG0200	Binds to the 23S rRNA
CHR48_RS06310	COG1841	ribosomal large subunit assembly
CHR48_RS06315	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CHR48_RS06320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CHR48_RS06325	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CHR48_RS06330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CHR48_RS06335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CHR48_RS06340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CHR48_RS06345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CHR48_RS06355	COG0255	Belongs to the universal ribosomal protein uL29 family
CHR48_RS06360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CHR48_RS06365	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CHR48_RS06370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CHR48_RS06375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CHR48_RS06380	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CHR48_RS06385	COG0089	rRNA binding
CHR48_RS06395	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CHR48_RS06400	COG0051	transcription antitermination factor activity, RNA binding
CHR48_RS06405	COG0142	geranyltranstransferase activity
CHR48_RS06410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CHR48_RS06420	COG0456	acetyltransferase
CHR48_RS06425	COG1214	PFAM Peptidase M22, glycoprotease
CHR48_RS06430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CHR48_RS06450	COG3870	Protein conserved in bacteria
CHR48_RS06455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CHR48_RS06480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CHR48_RS06490	COG0590	tRNA wobble adenosine to inosine editing
CHR48_RS06495	COG2813	Specifically methylates the guanine in position
CHR48_RS06505	COG2807	transmembrane transport
CHR48_RS06515	COG3620	sequence-specific DNA binding
CHR48_RS06560	COG0500	methyltransferase
CHR48_RS06565	COG1309	transcriptional regulator
CHR48_RS06580	COG1979	alcohol dehydrogenase
CHR48_RS06595	COG0085	RNA polymerase activity
CHR48_RS06600	COG0542	response to heat
CHR48_RS06605	COG4463	regulation of RNA biosynthetic process
CHR48_RS06630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CHR48_RS06635	COG1428	Deoxynucleoside kinase
CHR48_RS06640	COG1876	peptidase activity
CHR48_RS06645	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CHR48_RS06650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CHR48_RS06655	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CHR48_RS06660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CHR48_RS06665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CHR48_RS06670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CHR48_RS06675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CHR48_RS06680	COG0356	it plays a direct role in the translocation of protons across the membrane
CHR48_RS06685	COG2233	PERMEase
CHR48_RS06695	COG0702	epimerase
CHR48_RS06700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CHR48_RS06705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CHR48_RS06710	COG0009	L-threonylcarbamoyladenylate synthase
CHR48_RS06715	COG2890	protein-(glutamine-N5) methyltransferase activity
CHR48_RS06720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CHR48_RS06725	COG1435	thymidine kinase activity
CHR48_RS06735	COG3442	glutamine amidotransferase
CHR48_RS06740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CHR48_RS06745	COG1482	cell wall glycoprotein biosynthetic process
CHR48_RS06755	COG0110	maltose O-acetyltransferase activity
CHR48_RS06780	COG1132	(ABC) transporter
CHR48_RS06785	COG1132	(ABC) transporter
CHR48_RS06800	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CHR48_RS06805	COG0588	phosphoglycerate mutase activity
CHR48_RS06825	COG0708	Exodeoxyribonuclease III
CHR48_RS06835	COG1454	alcohol dehydrogenase
CHR48_RS06835	COG1012	belongs to the aldehyde dehydrogenase family
CHR48_RS06840	COG3590	peptidase
CHR48_RS06880	COG5039	Polysaccharide pyruvyl transferase
CHR48_RS06895	COG2801	Transposase and inactivated derivatives
CHR48_RS06900	COG1215	transferase activity, transferring glycosyl groups
CHR48_RS06905	COG1216	Glycosyl transferase, family 2
CHR48_RS06905	COG1442	glycosyl transferase family 8
CHR48_RS06925	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CHR48_RS06925	COG0463	Glycosyl transferase, family 2
CHR48_RS06940	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CHR48_RS06945	COG2188	Transcriptional regulator
CHR48_RS06950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CHR48_RS06955	COG2814	Major facilitator Superfamily
CHR48_RS06960	COG1418	mRNA catabolic process
CHR48_RS06975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CHR48_RS06980	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CHR48_RS06985	COG1215	transferase activity, transferring glycosyl groups
CHR48_RS07015	COG0765	amino acid transport
CHR48_RS07050	COG0656	L-ascorbic acid biosynthetic process
CHR48_RS07055	COG2160	L-arabinose isomerase activity
CHR48_RS07080	COG3940	Belongs to the glycosyl hydrolase 43 family
CHR48_RS07095	COG0534	Mate efflux family protein
CHR48_RS07100	COG0488	(ABC) transporter
CHR48_RS07105	COG1373	ATPase (AAA superfamily
CHR48_RS07110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CHR48_RS07115	COG1121	(ABC) transporter
CHR48_RS07125	COG1846	Transcriptional regulator
CHR48_RS07140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CHR48_RS07140	COG2755	lipolytic protein G-D-S-L family
CHR48_RS07145	COG3091	SprT-like family
CHR48_RS07190	COG4975	Glucose uptake
CHR48_RS07195	COG0477	Major facilitator Superfamily
CHR48_RS07200	COG3104	oligopeptide transport
CHR48_RS07255	COG1686	Belongs to the peptidase S11 family
CHR48_RS07265	COG0745	RESPONSE REGULATOR receiver
CHR48_RS07275	COG0012	GTP binding
CHR48_RS07280	COG4481	Protein conserved in bacteria
CHR48_RS07285	COG1475	DNA binding
CHR48_RS07290	COG1192	Involved in chromosome partitioning
CHR48_RS07295	COG0357	Ribosomal RNA small subunit methyltransferase G
CHR48_RS07305	COG1194	a g-specific adenine glycosylase
CHR48_RS07310	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CHR48_RS07350	COG5002	protein histidine kinase activity
CHR48_RS07355	COG0745	RESPONSE REGULATOR receiver
CHR48_RS07370	COG0318	PFAM AMP-dependent synthetase and ligase
CHR48_RS07375	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CHR48_RS07380	COG2050	protein possibly involved in aromatic compounds catabolism
CHR48_RS07385	COG1335	isochorismatase
CHR48_RS07390	COG2226	methyltransferase
CHR48_RS07400	COG4443	Transcriptional Coactivator p15 (PC4)
CHR48_RS07405	COG0252	asparaginase activity
CHR48_RS07410	COG0531	amino acid
CHR48_RS07415	COG1113	amino acid transport
CHR48_RS07420	COG0531	amino acid
CHR48_RS07430	COG4975	Glucose uptake
CHR48_RS07435	COG0477	Major facilitator Superfamily
CHR48_RS07445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CHR48_RS07450	COG2267	carboxylic ester hydrolase activity
CHR48_RS07455	COG4166	transmembrane transport
CHR48_RS07460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CHR48_RS07470	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CHR48_RS07480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CHR48_RS07490	COG3223	Belongs to the PsiE family
CHR48_RS07500	COG0531	amino acid
CHR48_RS07505	COG1228	amidohydrolase
CHR48_RS07520	COG2070	2-Nitropropane dioxygenase
CHR48_RS07530	COG0583	DNA-binding transcription factor activity
CHR48_RS07535	COG2855	membrane
CHR48_RS07545	COG3620	sequence-specific DNA binding
CHR48_RS07550	COG2855	membrane
CHR48_RS07565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CHR48_RS07590	COG1113	amino acid transport
CHR48_RS07620	COG0628	permease
CHR48_RS07630	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CHR48_RS07630	COG0392	lysyltransferase activity
CHR48_RS07640	COG1254	Belongs to the acylphosphatase family
CHR48_RS07645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHR48_RS07650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHR48_RS07655	COG0765	amino acid transport
CHR48_RS07660	COG1126	abc transporter atp-binding protein
CHR48_RS07670	COG1131	(ABC) transporter
CHR48_RS07680	COG0390	transport system, permease component
CHR48_RS07685	COG4619	ABC transporter
CHR48_RS07695	COG0656	L-ascorbic acid biosynthetic process
CHR48_RS07705	COG1132	(ABC) transporter
CHR48_RS07710	COG1846	Transcriptional regulator
CHR48_RS07730	COG1744	ABC transporter substrate-binding protein PnrA-like
CHR48_RS07735	COG0697	spore germination
CHR48_RS07745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CHR48_RS07760	COG0789	Transcriptional regulator
CHR48_RS07780	COG1131	(ABC) transporter
CHR48_RS07800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CHR48_RS07805	COG0505	Belongs to the CarA family
CHR48_RS07810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CHR48_RS07815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CHR48_RS07825	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CHR48_RS07830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CHR48_RS07835	COG0165	Argininosuccinate lyase
CHR48_RS07840	COG0137	argininosuccinate synthase activity
CHR48_RS07845	COG1744	ABC transporter substrate-binding protein PnrA-like
CHR48_RS07860	COG0697	spore germination
CHR48_RS07880	COG2723	6-phospho-beta-galactosidase activity
CHR48_RS07885	COG0517	IMP dehydrogenase activity
CHR48_RS07885	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CHR48_RS07910	COG1476	TRANSCRIPTIONal
CHR48_RS07980	COG1881	PFAM PEBP family protein
CHR48_RS08020	COG2252	PERMEase
CHR48_RS08025	COG3152	Membrane
CHR48_RS08045	COG0328	RNA-DNA hybrid ribonuclease activity
CHR48_RS08055	COG0561	phosphatase activity
CHR48_RS08060	COG2409	Drug exporters of the RND superfamily
CHR48_RS08060	COG1033	growth of symbiont in host cell
CHR48_RS08065	COG0577	efflux transmembrane transporter activity
CHR48_RS08070	COG1136	(ABC) transporter
CHR48_RS08080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CHR48_RS08085	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CHR48_RS08095	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHR48_RS08105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CHR48_RS08125	COG1113	amino acid transport
CHR48_RS08130	COG0569	domain protein
CHR48_RS08145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CHR48_RS08155	COG1120	ATPase activity
CHR48_RS08165	COG0706	membrane insertase activity
CHR48_RS08170	COG0594	ribonuclease P activity
CHR48_RS08175	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CHR48_RS08180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CHR48_RS08185	COG0592	DNA-directed DNA polymerase activity
CHR48_RS08190	COG2501	S4 domain
CHR48_RS08195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CHR48_RS08200	COG0187	DNA topoisomerase II activity
CHR48_RS08215	COG2153	protein acetylation
CHR48_RS08220	COG1368	sulfuric ester hydrolase activity
CHR48_RS08240	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CHR48_RS08300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHR48_RS08300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CHR48_RS08310	COG0084	hydrolase, TatD family'
CHR48_RS08315	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CHR48_RS08320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CHR48_RS08325	COG1253	flavin adenine dinucleotide binding
CHR48_RS08330	COG1253	flavin adenine dinucleotide binding
CHR48_RS08335	COG4466	Protein conserved in bacteria
CHR48_RS08340	COG2131	deaminase
CHR48_RS08350	COG1316	TRANSCRIPTIONal
CHR48_RS08355	COG1263	PTS System
CHR48_RS08355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CHR48_RS08370	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CHR48_RS08385	COG0737	Belongs to the 5'-nucleotidase family
CHR48_RS08390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CHR48_RS08395	COG1983	PspC domain protein
CHR48_RS08400	COG1695	Transcriptional regulator
CHR48_RS08415	COG1968	undecaprenyl-diphosphatase activity
CHR48_RS08420	COG2818	Glycosylase
CHR48_RS08445	COG3507	Belongs to the glycosyl hydrolase 43 family
CHR48_RS08450	COG2211	Major facilitator Superfamily
CHR48_RS08460	COG2115	Belongs to the xylose isomerase family
CHR48_RS08470	COG0667	Aldo Keto reductase
CHR48_RS08485	COG0477	Major facilitator Superfamily
CHR48_RS08490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CHR48_RS08505	COG1309	transcriptional regulator
CHR48_RS08510	COG1511	domain protein
CHR48_RS08510	COG1511	domain protein
CHR48_RS08515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CHR48_RS08525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CHR48_RS08530	COG0297	glycogen (starch) synthase activity
CHR48_RS08535	COG0058	SHG alpha-glucan phosphorylase activity
CHR48_RS08545	COG0193	aminoacyl-tRNA hydrolase activity
CHR48_RS08550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CHR48_RS08555	COG2244	polysaccharide biosynthetic process
CHR48_RS08560	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CHR48_RS08570	COG0037	tRNA processing
CHR48_RS08585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CHR48_RS08590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CHR48_RS08655	COG2261	transglycosylase associated protein
CHR48_RS08660	COG0656	L-ascorbic acid biosynthetic process
CHR48_RS08670	COG1737	Transcriptional regulator
CHR48_RS08675	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CHR48_RS08725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CHR48_RS08740	COG1216	Glycosyl transferase, family 2
CHR48_RS08755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CHR48_RS08760	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CHR48_RS08765	COG1447	Phosphotransferase system cellobiose-specific component IIA
CHR48_RS08770	COG2723	6-phospho-beta-galactosidase activity
CHR48_RS08775	COG2723	6-phospho-beta-galactosidase activity
CHR48_RS08780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CHR48_RS08790	COG0436	Aminotransferase
CHR48_RS08810	COG2211	Major facilitator Superfamily
CHR48_RS08810	COG2190	(PTS) system
CHR48_RS08815	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CHR48_RS08820	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CHR48_RS08825	COG0444	Belongs to the ABC transporter superfamily
CHR48_RS08830	COG4608	Belongs to the ABC transporter superfamily
CHR48_RS08840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHR48_RS08845	COG0747	negative chemotaxis
CHR48_RS08855	COG1132	(ABC) transporter
CHR48_RS08870	COG1956	GAF domain-containing protein
CHR48_RS08885	COG2233	PERMEase
CHR48_RS08890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CHR48_RS08895	COG4989	oxidoreductase activity
CHR48_RS08900	COG1620	l-lactate permease
CHR48_RS08910	COG1028	Short-chain dehydrogenase reductase Sdr
CHR48_RS08915	COG2084	Dehydrogenase
CHR48_RS08945	COG0438	transferase activity, transferring glycosyl groups
CHR48_RS09055	COG3842	ATPase activity
CHR48_RS09060	COG1175	transmembrane transport
CHR48_RS09065	COG0395	ABC-type sugar transport system, permease component
CHR48_RS09080	COG0542	response to heat
CHR48_RS09085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHR48_RS09090	COG2040	homocysteine
CHR48_RS09095	COG0833	amino acid
CHR48_RS09100	COG0308	aminopeptidase N
CHR48_RS09120	COG2207	Transcriptional regulator
CHR48_RS09135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CHR48_RS09140	COG0745	RESPONSE REGULATOR receiver
CHR48_RS09145	COG2205	protein histidine kinase activity
CHR48_RS09155	COG1316	TRANSCRIPTIONal
CHR48_RS09165	COG0024	Methionine aminopeptidase
CHR48_RS09175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CHR48_RS09185	COG2801	Transposase and inactivated derivatives
CHR48_RS09195	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CHR48_RS09210	COG2723	6-phospho-beta-galactosidase activity
CHR48_RS09235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CHR48_RS09245	COG0671	phosphoesterase, PA-phosphatase related
CHR48_RS09250	COG0495	leucyl-tRNA aminoacylation
CHR48_RS09255	COG0438	transferase activity, transferring glycosyl groups
CHR48_RS09265	COG2244	polysaccharide biosynthetic process
CHR48_RS09280	COG0626	cystathionine gamma-synthase activity
CHR48_RS09285	COG1902	pentaerythritol trinitrate reductase activity
CHR48_RS09295	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CHR48_RS09300	COG0531	amino acid
CHR48_RS09305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHR48_RS09320	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CHR48_RS09330	COG1064	alcohol dehydrogenase
CHR48_RS09335	COG2814	Major facilitator Superfamily
CHR48_RS09350	COG1051	belongs to the nudix hydrolase family
CHR48_RS09355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CHR48_RS09365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CHR48_RS09380	COG0360	Binds together with S18 to 16S ribosomal RNA
CHR48_RS09385	COG0629	single-stranded DNA binding
CHR48_RS09390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CHR48_RS09420	COG0745	RESPONSE REGULATOR receiver
CHR48_RS09440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CHR48_RS09445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CHR48_RS09455	COG1078	dGTPase activity
CHR48_RS09460	COG0561	phosphatase activity
CHR48_RS09465	COG3343	RNA polymerase activity
CHR48_RS09475	COG0504	CTP synthase activity
CHR48_RS09480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CHR48_RS09495	COG2337	Toxic component of a toxin-antitoxin (TA) module
CHR48_RS09515	COG1696	Membrane protein involved in D-alanine export
CHR48_RS09525	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CHR48_RS09545	COG3973	AAA domain
CHR48_RS09560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CHR48_RS09565	COG2211	Major facilitator Superfamily
CHR48_RS09590	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CHR48_RS09590	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CHR48_RS09595	COG1268	BioY protein
CHR48_RS09600	COG0194	GDP metabolic process
CHR48_RS09615	COG1126	abc transporter atp-binding protein
CHR48_RS09620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CHR48_RS09625	COG0765	amino acid transport
CHR48_RS09630	COG0765	amino acid transport
CHR48_RS09635	COG4166	transmembrane transport
CHR48_RS09640	COG0601	transmembrane transport
CHR48_RS09645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CHR48_RS09650	COG0444	Belongs to the ABC transporter superfamily
CHR48_RS09655	COG4608	Belongs to the ABC transporter superfamily
CHR48_RS09665	COG0359	binds to the 23S rRNA
CHR48_RS09670	COG0305	Participates in initiation and elongation during chromosome replication
CHR48_RS09675	COG2814	Major facilitator Superfamily
CHR48_RS09685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CHR48_RS09710	COG2832	Protein of unknown function (DUF454)
CHR48_RS09720	COG1744	ABC transporter substrate-binding protein PnrA-like
CHR48_RS09725	COG1744	ABC transporter substrate-binding protein PnrA-like
CHR48_RS09740	COG0492	ferredoxin-NADP+ reductase activity
CHR48_RS09755	COG0588	phosphoglycerate mutase activity
CHR48_RS09760	COG0386	Belongs to the glutathione peroxidase family
CHR48_RS09780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CHR48_RS09785	COG0628	permease
CHR48_RS09790	COG0640	Transcriptional regulator
CHR48_RS09800	COG0446	pyridine nucleotide-disulphide oxidoreductase
CHR48_RS09805	COG1744	ABC transporter substrate-binding protein PnrA-like
CHR48_RS09810	COG3845	ABC transporter
CHR48_RS09815	COG4603	Belongs to the binding-protein-dependent transport system permease family
CHR48_RS09820	COG1079	Belongs to the binding-protein-dependent transport system permease family
CHR48_RS09825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CHR48_RS09830	COG1077	Cell shape determining protein MreB Mrl
CHR48_RS09840	COG0772	Belongs to the SEDS family
CHR48_RS09845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CHR48_RS09865	COG0561	phosphatase activity
CHR48_RS09870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CHR48_RS09870	COG2169	Transcriptional regulator
CHR48_RS09875	COG0561	phosphatase activity
CHR48_RS09885	COG0577	efflux transmembrane transporter activity
CHR48_RS09885	COG1136	(ABC) transporter
CHR48_RS09895	COG2188	Transcriptional regulator
CHR48_RS09905	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CHR48_RS09910	COG2814	Major facilitator Superfamily
CHR48_RS09920	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CHR48_RS09925	COG0352	thiamine-phosphate diphosphorylase activity
CHR48_RS09935	COG2252	PERMEase
CHR48_RS09945	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CHR48_RS09950	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CHR48_RS09990	COG0604	alcohol dehydrogenase
CHR48_RS09995	COG4166	transmembrane transport
CHR48_RS10000	COG1228	amidohydrolase
CHR48_RS10015	COG2814	Major facilitator Superfamily
CHR48_RS10020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CHR48_RS10025	COG0656	L-ascorbic acid biosynthetic process
CHR48_RS10030	COG1307	EDD domain protein, DegV family
CHR48_RS10045	COG1435	thymidine kinase activity
CHR48_RS10050	COG2076	Multidrug Resistance protein
CHR48_RS10055	COG2076	Multidrug Resistance protein
CHR48_RS10065	COG0307	riboflavin synthase, alpha
CHR48_RS10070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CHR48_RS10070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CHR48_RS10075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CHR48_RS10095	COG1174	glycine betaine transport
CHR48_RS10105	COG1979	alcohol dehydrogenase
CHR48_RS10110	COG1811	Na channel or pump
CHR48_RS10135	COG2246	polysaccharide biosynthetic process
CHR48_RS10140	COG0561	phosphatase activity
CHR48_RS10145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CHR48_RS10150	COG4589	Belongs to the CDS family
CHR48_RS10155	COG0750	zinc metalloprotease
CHR48_RS10160	COG0442	prolyl-tRNA aminoacylation
CHR48_RS10245	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CHR48_RS10250	COG1040	competence protein
CHR48_RS10255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CHR48_RS10260	COG2873	o-acetylhomoserine
CHR48_RS10270	COG2183	response to ionizing radiation
CHR48_RS10295	COG1940	carbohydrate kinase activity
CHR48_RS10300	COG2723	6-phospho-beta-galactosidase activity
CHR48_RS10305	COG3711	transcriptional antiterminator
CHR48_RS10325	COG1309	transcriptional regulator
CHR48_RS10345	COG2217	Heavy metal translocating P-type atpase
CHR48_RS10350	COG2814	Major facilitator Superfamily
CHR48_RS10390	COG0438	transferase activity, transferring glycosyl groups
CHR48_RS10440	COG2217	Heavy metal translocating P-type atpase
CHR48_RS10450	COG2235	arginine
CHR48_RS10455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CHR48_RS10480	COG3759	membrane
CHR48_RS10485	COG1136	(ABC) transporter
CHR48_RS10490	COG0577	efflux transmembrane transporter activity
CHR48_RS10520	COG1609	Transcriptional regulator
CHR48_RS10535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CHR48_RS10550	COG0246	Mannitol dehydrogenase
CHR48_RS10555	COG1312	Catalyzes the dehydration of D-mannonate
CHR48_RS10560	COG1904	glucuronate isomerase
CHR48_RS10565	COG0800	Aldolase
CHR48_RS10570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CHR48_RS10575	COG1464	Belongs to the NlpA lipoprotein family
CHR48_RS10580	COG4946	Tricorn protease homolog
CHR48_RS10580	COG1506	peptidase
CHR48_RS10580	COG0823	Involved in the tonB-independent uptake of proteins
CHR48_RS10595	COG0561	phosphatase activity
CHR48_RS10635	COG0302	gtp cyclohydrolase
CHR48_RS10635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CHR48_RS10640	COG0302	gtp cyclohydrolase
CHR48_RS10645	COG0285	dihydrofolate synthase activity
CHR48_RS10655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CHR48_RS10660	COG1116	anion transmembrane transporter activity
CHR48_RS10670	COG0318	PFAM AMP-dependent synthetase and ligase
CHR48_RS10680	COG2223	nitrite transmembrane transporter activity
CHR48_RS10700	COG1609	Transcriptional regulator
CHR48_RS10715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CHR48_RS10735	COG1609	Transcriptional regulator
CHR48_RS10740	COG1869	D-ribose catabolic process
CHR48_RS10745	COG0738	Major facilitator superfamily
CHR48_RS10785	COG0494	nUDIX hydrolase
CHR48_RS10800	COG2801	Transposase and inactivated derivatives
CHR48_RS10870	COG0516	GMP reductase activity