locus-tag	class	description
HUW87_RS00010	COG4989	oxidoreductase activity
HUW87_RS00015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUW87_RS00020	COG2233	PERMEase
HUW87_RS00045	COG1620	l-lactate permease
HUW87_RS00050	COG4989	oxidoreductase activity
HUW87_RS00055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUW87_RS00060	COG2233	PERMEase
HUW87_RS00085	COG1620	l-lactate permease
HUW87_RS00090	COG4989	oxidoreductase activity
HUW87_RS00120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW87_RS00140	COG1132	(ABC) transporter
HUW87_RS00145	COG1132	(ABC) transporter
HUW87_RS00150	COG0747	negative chemotaxis
HUW87_RS00155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW87_RS00160	COG0601	transmembrane transport
HUW87_RS00165	COG4608	Belongs to the ABC transporter superfamily
HUW87_RS00170	COG0444	Belongs to the ABC transporter superfamily
HUW87_RS00175	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HUW87_RS00180	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUW87_RS00185	COG2190	(PTS) system
HUW87_RS00185	COG2211	Major facilitator Superfamily
HUW87_RS00205	COG0436	Aminotransferase
HUW87_RS00215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUW87_RS00220	COG2723	6-phospho-beta-galactosidase activity
HUW87_RS00225	COG2723	6-phospho-beta-galactosidase activity
HUW87_RS00230	COG1447	Phosphotransferase system cellobiose-specific component IIA
HUW87_RS00235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUW87_RS00240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUW87_RS00255	COG1216	Glycosyl transferase, family 2
HUW87_RS00270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUW87_RS00325	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUW87_RS00330	COG1737	Transcriptional regulator
HUW87_RS00340	COG0656	L-ascorbic acid biosynthetic process
HUW87_RS00345	COG2261	transglycosylase associated protein
HUW87_RS00410	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUW87_RS00415	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HUW87_RS00430	COG0037	tRNA processing
HUW87_RS00440	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HUW87_RS00445	COG2244	polysaccharide biosynthetic process
HUW87_RS00450	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUW87_RS00455	COG0193	aminoacyl-tRNA hydrolase activity
HUW87_RS00465	COG0058	SHG alpha-glucan phosphorylase activity
HUW87_RS00470	COG0297	glycogen (starch) synthase activity
HUW87_RS00475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUW87_RS00485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUW87_RS00495	COG1511	domain protein
HUW87_RS00495	COG1511	domain protein
HUW87_RS00500	COG1309	transcriptional regulator
HUW87_RS00515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUW87_RS00520	COG0477	Major facilitator Superfamily
HUW87_RS00530	COG0667	Aldo Keto reductase
HUW87_RS00540	COG2115	Belongs to the xylose isomerase family
HUW87_RS00550	COG2211	Major facilitator Superfamily
HUW87_RS00555	COG3507	Belongs to the glycosyl hydrolase 43 family
HUW87_RS00580	COG2818	Glycosylase
HUW87_RS00585	COG1968	undecaprenyl-diphosphatase activity
HUW87_RS00600	COG1695	Transcriptional regulator
HUW87_RS00605	COG1983	PspC domain protein
HUW87_RS00610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUW87_RS00620	COG2801	Transposase and inactivated derivatives
HUW87_RS00625	COG0737	Belongs to the 5'-nucleotidase family
HUW87_RS00640	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HUW87_RS00655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUW87_RS00655	COG1263	PTS System
HUW87_RS00660	COG1316	TRANSCRIPTIONal
HUW87_RS00670	COG2131	deaminase
HUW87_RS00675	COG4466	Protein conserved in bacteria
HUW87_RS00680	COG1253	flavin adenine dinucleotide binding
HUW87_RS00685	COG1253	flavin adenine dinucleotide binding
HUW87_RS00690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUW87_RS00695	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HUW87_RS00700	COG0084	hydrolase, TatD family'
HUW87_RS00710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW87_RS00710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW87_RS00770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUW87_RS00790	COG1368	sulfuric ester hydrolase activity
HUW87_RS00795	COG2153	protein acetylation
HUW87_RS00810	COG0187	DNA topoisomerase II activity
HUW87_RS00815	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUW87_RS00820	COG2501	S4 domain
HUW87_RS00825	COG0592	DNA-directed DNA polymerase activity
HUW87_RS00830	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUW87_RS00835	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUW87_RS00840	COG0594	ribonuclease P activity
HUW87_RS00845	COG0706	membrane insertase activity
HUW87_RS00855	COG1120	ATPase activity
HUW87_RS00865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUW87_RS00880	COG0569	domain protein
HUW87_RS00885	COG1113	amino acid transport
HUW87_RS00905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW87_RS00915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUW87_RS00920	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUW87_RS00930	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HUW87_RS00935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUW87_RS00945	COG1136	(ABC) transporter
HUW87_RS00950	COG0577	efflux transmembrane transporter activity
HUW87_RS00955	COG2409	Drug exporters of the RND superfamily
HUW87_RS00955	COG1033	growth of symbiont in host cell
HUW87_RS00960	COG0561	phosphatase activity
HUW87_RS00970	COG0328	RNA-DNA hybrid ribonuclease activity
HUW87_RS00990	COG3152	Membrane
HUW87_RS00995	COG2252	PERMEase
HUW87_RS01045	COG1881	PFAM PEBP family protein
HUW87_RS01070	COG1476	TRANSCRIPTIONal
HUW87_RS01100	COG0517	IMP dehydrogenase activity
HUW87_RS01100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUW87_RS01105	COG2723	6-phospho-beta-galactosidase activity
HUW87_RS01135	COG0697	spore germination
HUW87_RS01160	COG1744	ABC transporter substrate-binding protein PnrA-like
HUW87_RS01165	COG0137	argininosuccinate synthase activity
HUW87_RS01170	COG0165	Argininosuccinate lyase
HUW87_RS01180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUW87_RS01185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUW87_RS01190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUW87_RS01195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUW87_RS01200	COG0505	Belongs to the CarA family
HUW87_RS01225	COG1131	(ABC) transporter
HUW87_RS01235	COG0789	Transcriptional regulator
HUW87_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_RS01250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW87_RS01260	COG0697	spore germination
HUW87_RS01285	COG1846	Transcriptional regulator
HUW87_RS01290	COG1132	(ABC) transporter
HUW87_RS01300	COG0656	L-ascorbic acid biosynthetic process
HUW87_RS01310	COG4619	ABC transporter
HUW87_RS01315	COG0390	transport system, permease component
HUW87_RS01325	COG1131	(ABC) transporter
HUW87_RS01335	COG1126	abc transporter atp-binding protein
HUW87_RS01340	COG0765	amino acid transport
HUW87_RS01345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW87_RS01350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW87_RS01355	COG1254	Belongs to the acylphosphatase family
HUW87_RS01365	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUW87_RS01365	COG0392	lysyltransferase activity
HUW87_RS01375	COG0628	permease
HUW87_RS01405	COG1113	amino acid transport
HUW87_RS01430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUW87_RS01435	COG0456	acetyltransferase
HUW87_RS01435	COG0454	-acetyltransferase
HUW87_RS01445	COG2855	membrane
HUW87_RS01455	COG2855	membrane
HUW87_RS01460	COG0583	DNA-binding transcription factor activity
HUW87_RS01470	COG2070	2-Nitropropane dioxygenase
HUW87_RS01485	COG1228	amidohydrolase
HUW87_RS01490	COG0531	amino acid
HUW87_RS01500	COG3223	Belongs to the PsiE family
HUW87_RS01510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW87_RS01520	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUW87_RS01530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUW87_RS01535	COG4166	transmembrane transport
HUW87_RS01540	COG2267	carboxylic ester hydrolase activity
HUW87_RS01550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HUW87_RS01565	COG0477	Major facilitator Superfamily
HUW87_RS01570	COG4975	Glucose uptake
HUW87_RS01580	COG0531	amino acid
HUW87_RS01585	COG1113	amino acid transport
HUW87_RS01590	COG0531	amino acid
HUW87_RS01595	COG0252	asparaginase activity
HUW87_RS01600	COG4443	Transcriptional Coactivator p15 (PC4)
HUW87_RS01615	COG2226	methyltransferase
HUW87_RS01620	COG1335	isochorismatase
HUW87_RS01625	COG2050	protein possibly involved in aromatic compounds catabolism
HUW87_RS01630	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HUW87_RS01635	COG0318	PFAM AMP-dependent synthetase and ligase
HUW87_RS01650	COG0745	RESPONSE REGULATOR receiver
HUW87_RS01655	COG5002	protein histidine kinase activity
HUW87_RS01695	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HUW87_RS01700	COG1194	a g-specific adenine glycosylase
HUW87_RS01710	COG0357	Ribosomal RNA small subunit methyltransferase G
HUW87_RS01715	COG1192	Involved in chromosome partitioning
HUW87_RS01720	COG1475	DNA binding
HUW87_RS01725	COG4481	Protein conserved in bacteria
HUW87_RS01730	COG0012	GTP binding
HUW87_RS01740	COG0745	RESPONSE REGULATOR receiver
HUW87_RS01750	COG1686	Belongs to the peptidase S11 family
HUW87_RS01755	COG2801	Transposase and inactivated derivatives
HUW87_RS01810	COG3104	oligopeptide transport
HUW87_RS01815	COG0477	Major facilitator Superfamily
HUW87_RS01820	COG4975	Glucose uptake
HUW87_RS01870	COG3091	SprT-like family
HUW87_RS01875	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUW87_RS01875	COG2755	lipolytic protein G-D-S-L family
HUW87_RS01880	COG1846	Transcriptional regulator
HUW87_RS01890	COG1121	(ABC) transporter
HUW87_RS01895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUW87_RS01900	COG1373	ATPase (AAA superfamily
HUW87_RS01905	COG0488	(ABC) transporter
HUW87_RS01910	COG0534	Mate efflux family protein
HUW87_RS01925	COG3940	Belongs to the glycosyl hydrolase 43 family
HUW87_RS01945	COG2160	L-arabinose isomerase activity
HUW87_RS01950	COG0656	L-ascorbic acid biosynthetic process
HUW87_RS01975	COG0765	amino acid transport
HUW87_RS02015	COG1215	transferase activity, transferring glycosyl groups
HUW87_RS02020	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HUW87_RS02025	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUW87_RS02040	COG1418	mRNA catabolic process
HUW87_RS02045	COG2814	Major facilitator Superfamily
HUW87_RS02050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW87_RS02055	COG2188	Transcriptional regulator
HUW87_RS02060	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HUW87_RS02070	COG1216	Glycosyl transferase, family 2
HUW87_RS02080	COG2801	Transposase and inactivated derivatives
HUW87_RS02090	COG5039	Polysaccharide pyruvyl transferase
HUW87_RS02135	COG3590	peptidase
HUW87_RS02145	COG1012	belongs to the aldehyde dehydrogenase family
HUW87_RS02145	COG1454	alcohol dehydrogenase
HUW87_RS02155	COG1373	ATPase (AAA superfamily
HUW87_RS02160	COG0708	Exodeoxyribonuclease III
HUW87_RS02180	COG0588	phosphoglycerate mutase activity
HUW87_RS02185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUW87_RS02200	COG1132	(ABC) transporter
HUW87_RS02205	COG1132	(ABC) transporter
HUW87_RS02210	COG1373	ATPase (AAA superfamily
HUW87_RS02250	COG1482	cell wall glycoprotein biosynthetic process
HUW87_RS02255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUW87_RS02260	COG3442	glutamine amidotransferase
HUW87_RS02270	COG1435	thymidine kinase activity
HUW87_RS02275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUW87_RS02280	COG2890	protein-(glutamine-N5) methyltransferase activity
HUW87_RS02285	COG0009	L-threonylcarbamoyladenylate synthase
HUW87_RS02290	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUW87_RS02295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUW87_RS02300	COG0702	epimerase
HUW87_RS02310	COG2233	PERMEase
HUW87_RS02315	COG0356	it plays a direct role in the translocation of protons across the membrane
HUW87_RS02320	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW87_RS02325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUW87_RS02330	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUW87_RS02335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUW87_RS02340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUW87_RS02345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUW87_RS02350	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUW87_RS02355	COG1876	peptidase activity
HUW87_RS02360	COG1428	Deoxynucleoside kinase
HUW87_RS02365	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUW87_RS02390	COG4463	regulation of RNA biosynthetic process
HUW87_RS02395	COG0542	response to heat
HUW87_RS02400	COG0085	RNA polymerase activity
HUW87_RS02420	COG1979	alcohol dehydrogenase
HUW87_RS02445	COG1309	transcriptional regulator
HUW87_RS02450	COG0500	methyltransferase
HUW87_RS02495	COG3620	sequence-specific DNA binding
HUW87_RS02505	COG2807	transmembrane transport
HUW87_RS02515	COG2813	Specifically methylates the guanine in position
HUW87_RS02520	COG0590	tRNA wobble adenosine to inosine editing
HUW87_RS02530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUW87_RS02555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUW87_RS02560	COG3870	Protein conserved in bacteria
HUW87_RS02580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUW87_RS02585	COG1214	PFAM Peptidase M22, glycoprotease
HUW87_RS02590	COG0456	acetyltransferase
HUW87_RS02600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUW87_RS02605	COG0142	geranyltranstransferase activity
HUW87_RS02610	COG0051	transcription antitermination factor activity, RNA binding
HUW87_RS02615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUW87_RS02625	COG0089	rRNA binding
HUW87_RS02630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUW87_RS02635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUW87_RS02640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUW87_RS02645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUW87_RS02650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUW87_RS02655	COG0255	Belongs to the universal ribosomal protein uL29 family
HUW87_RS02665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUW87_RS02670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUW87_RS02675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUW87_RS02680	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUW87_RS02685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUW87_RS02690	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUW87_RS02695	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUW87_RS02700	COG1841	ribosomal large subunit assembly
HUW87_RS02705	COG0200	Binds to the 23S rRNA
HUW87_RS02720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUW87_RS02725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUW87_RS02730	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUW87_RS02735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUW87_RS02740	COG0202	RNA polymerase activity
HUW87_RS02745	COG0203	ribosomal protein L17
HUW87_RS02770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUW87_RS02785	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUW87_RS02810	COG0583	DNA-binding transcription factor activity
HUW87_RS02820	COG1053	succinate dehydrogenase
HUW87_RS02825	COG0471	metal ion transport
HUW87_RS02830	COG0039	L-malate dehydrogenase activity
HUW87_RS02835	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUW87_RS02840	COG0215	cysteine-tRNA ligase activity
HUW87_RS02845	COG0626	cystathionine gamma-synthase activity
HUW87_RS02850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUW87_RS02855	COG1464	Belongs to the NlpA lipoprotein family
HUW87_RS02860	COG1854	S-ribosylhomocysteine lyase activity
HUW87_RS02865	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HUW87_RS02870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW87_RS02885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUW87_RS02890	COG0250	Participates in transcription elongation, termination and antitermination
HUW87_RS02895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUW87_RS02900	COG0081	regulation of translation
HUW87_RS02905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUW87_RS02910	COG0222	ribosome binding
HUW87_RS02930	COG1121	(ABC) transporter
HUW87_RS02935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUW87_RS02940	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUW87_RS02945	COG1252	NADH dehydrogenase
HUW87_RS02955	COG1122	ATPase activity
HUW87_RS02960	COG1122	ATPase activity
HUW87_RS02970	COG0101	tRNA pseudouridine synthase activity
HUW87_RS02975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUW87_RS03000	COG0028	Belongs to the TPP enzyme family
HUW87_RS03015	COG1573	uracil-dna glycosylase
HUW87_RS03030	COG0366	Alpha amylase catalytic
HUW87_RS03040	COG0671	phosphoesterase, PA-phosphatase related
HUW87_RS03045	COG2226	methyltransferase
HUW87_RS03060	COG2814	Major facilitator Superfamily
HUW87_RS03065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUW87_RS03080	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUW87_RS03085	COG1481	regulation of sporulation
HUW87_RS03090	COG0740	serine-type endopeptidase activity
HUW87_RS03105	COG1263	PTS System
HUW87_RS03105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUW87_RS03115	COG1914	H( )-stimulated, divalent metal cation uptake system
HUW87_RS03135	COG0582	viral genome integration into host DNA
HUW87_RS03140	COG3759	membrane
HUW87_RS03150	COG1396	sequence-specific DNA binding
HUW87_RS03240	COG1122	ATPase activity
HUW87_RS03245	COG1122	ATPase activity
HUW87_RS03255	COG4166	transmembrane transport
HUW87_RS03260	COG1228	amidohydrolase
HUW87_RS03310	COG2801	Transposase and inactivated derivatives
HUW87_RS03320	COG0039	L-malate dehydrogenase activity
HUW87_RS03325	COG0028	Belongs to the TPP enzyme family
HUW87_RS03330	COG3527	Alpha-acetolactate decarboxylase
HUW87_RS03340	COG3942	CHAP domain
HUW87_RS03340	COG1388	LysM domain
HUW87_RS03345	COG0791	NLP P60 protein
HUW87_RS03355	COG0756	dUTP diphosphatase activity
HUW87_RS03365	COG4956	integral membrane protein (PIN domain superfamily)
HUW87_RS03375	COG0653	protein targeting
HUW87_RS03380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUW87_RS03395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUW87_RS03405	COG1733	regulation of RNA biosynthetic process
HUW87_RS03410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUW87_RS03415	COG0072	phenylalanine-tRNA ligase activity
HUW87_RS03415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW87_RS03420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUW87_RS03425	COG0514	ATP-dependent DNA helicase (RecQ)
HUW87_RS03430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUW87_RS03440	COG0768	penicillin binding
HUW87_RS03445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUW87_RS03460	COG1940	carbohydrate kinase activity
HUW87_RS03480	COG3942	CHAP domain
HUW87_RS03500	COG0584	glycerophosphoryl diester phosphodiesterase
HUW87_RS03505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUW87_RS03510	COG0789	Transcriptional regulator
HUW87_RS03515	COG0174	glutamine synthetase
HUW87_RS03540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUW87_RS03545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUW87_RS03550	COG1472	Belongs to the glycosyl hydrolase 3 family
HUW87_RS03580	COG0778	Nitroreductase
HUW87_RS03585	COG1169	isochorismate synthase
HUW87_RS03590	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HUW87_RS03595	COG0596	Alpha beta hydrolase
HUW87_RS03600	COG4948	Mandelate Racemase Muconate Lactonizing
HUW87_RS03630	COG0737	Belongs to the 5'-nucleotidase family
HUW87_RS03635	COG4470	Protein conserved in bacteria
HUW87_RS03640	COG0647	UMP catabolic process
HUW87_RS03645	COG4166	transmembrane transport
HUW87_RS03650	COG0673	inositol 2-dehydrogenase activity
HUW87_RS03690	COG0573	inorganic phosphate transmembrane transporter activity
HUW87_RS03695	COG0581	inorganic phosphate transmembrane transporter activity
HUW87_RS03700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUW87_RS03705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUW87_RS03710	COG0704	Plays a role in the regulation of phosphate uptake
HUW87_RS03715	COG2137	regulation of response to DNA damage stimulus
HUW87_RS03750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HUW87_RS03760	COG5506	Protein of unknown function (DUF1694)
HUW87_RS03770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUW87_RS03880	COG1272	protein, Hemolysin III
HUW87_RS03910	COG0525	valine-tRNA ligase activity
HUW87_RS03920	COG0285	dihydrofolate synthase activity
HUW87_RS03950	COG0488	(ABC) transporter
HUW87_RS03955	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUW87_RS03960	COG0459	protein refolding
HUW87_RS03965	COG0531	amino acid
HUW87_RS03975	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUW87_RS03980	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HUW87_RS03985	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HUW87_RS03995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUW87_RS04000	COG1713	HD superfamily hydrolase involved in NAD metabolism
HUW87_RS04005	COG0799	negative regulation of ribosome biogenesis
HUW87_RS04010	COG2226	methyltransferase
HUW87_RS04015	COG1323	Belongs to the UPF0348 family
HUW87_RS04025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUW87_RS04030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUW87_RS04130	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUW87_RS04135	COG3764	Sortase (surface protein transpeptidase)
HUW87_RS04140	COG0363	glucosamine-6-phosphate deaminase activity
HUW87_RS04145	COG0776	regulation of translation
HUW87_RS04155	COG0577	efflux transmembrane transporter activity
HUW87_RS04160	COG1136	(ABC) transporter
HUW87_RS04175	COG4720	Psort location CytoplasmicMembrane, score
HUW87_RS04180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUW87_RS04185	COG1570	exodeoxyribonuclease VII activity
HUW87_RS04200	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HUW87_RS04205	COG1438	arginine binding
HUW87_RS04210	COG0497	DNA recombination
HUW87_RS04225	COG0194	GDP metabolic process
HUW87_RS04235	COG0586	Pfam SNARE associated Golgi protein
HUW87_RS04240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW87_RS04245	COG1098	S1 RNA binding domain
HUW87_RS04365	COG4684	Psort location CytoplasmicMembrane, score
HUW87_RS04370	COG1271	oxidase subunit
HUW87_RS04375	COG1294	oxidase, subunit
HUW87_RS04380	COG4988	ABC transporter
HUW87_RS04385	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HUW87_RS04390	COG1388	LysM domain
HUW87_RS04390	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUW87_RS04395	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HUW87_RS04410	COG1278	Cold shock
HUW87_RS04415	COG0494	nUDIX hydrolase
HUW87_RS04425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUW87_RS04430	COG0346	lactoylglutathione lyase activity
HUW87_RS04435	COG0400	carboxylic ester hydrolase activity
HUW87_RS04450	COG2801	Transposase and inactivated derivatives
HUW87_RS04455	COG0741	lytic transglycosylase activity
HUW87_RS04475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HUW87_RS04480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUW87_RS04485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUW87_RS04495	COG4120	Belongs to the binding-protein-dependent transport system permease family
HUW87_RS04505	COG0038	chloride channel
HUW87_RS04510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUW87_RS04515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUW87_RS04520	COG1307	EDD domain protein, DegV family
HUW87_RS04525	COG1263	PTS System
HUW87_RS04525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUW87_RS04525	COG2190	(PTS) system
HUW87_RS04545	COG1077	Cell shape determining protein MreB Mrl
HUW87_RS04555	COG3338	carbonate dehydratase activity
HUW87_RS04565	COG0765	amino acid transport
HUW87_RS04570	COG1126	abc transporter atp-binding protein
HUW87_RS04575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW87_RS04580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW87_RS04580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUW87_RS04585	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUW87_RS04590	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUW87_RS04595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUW87_RS04600	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUW87_RS04605	COG0047	phosphoribosylformylglycinamidine synthase activity
HUW87_RS04610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUW87_RS04620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUW87_RS04625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUW87_RS04630	COG0138	bifunctional purine biosynthesis protein purh
HUW87_RS04635	COG0151	Belongs to the GarS family
HUW87_RS04640	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HUW87_RS04655	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUW87_RS04675	COG0833	amino acid
HUW87_RS04685	COG2264	protein methyltransferase activity
HUW87_RS04690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUW87_RS04700	COG2001	Belongs to the MraZ family
HUW87_RS04705	COG0275	rRNA processing
HUW87_RS04715	COG0768	penicillin binding
HUW87_RS04720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUW87_RS04725	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUW87_RS04730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUW87_RS04735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUW87_RS04740	COG0849	cell division
HUW87_RS04750	COG1799	cell septum assembly
HUW87_RS04765	COG3599	regulation of cell shape
HUW87_RS04785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW87_RS04790	COG0217	transcriptional regulatory protein
HUW87_RS04795	COG2252	PERMEase
HUW87_RS04800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUW87_RS04840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUW87_RS04845	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUW87_RS04850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUW87_RS04855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUW87_RS04855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUW87_RS04860	COG0631	protein serine/threonine phosphatase activity
HUW87_RS04865	COG0515	serine threonine protein kinase
HUW87_RS04865	COG2815	serine threonine protein kinase
HUW87_RS04870	COG1162	GTPase activity
HUW87_RS04875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUW87_RS04885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUW87_RS04895	COG1461	Dihydroxyacetone kinase
HUW87_RS04915	COG0438	transferase activity, transferring glycosyl groups
HUW87_RS04930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUW87_RS04935	COG0416	fatty acid biosynthetic process
HUW87_RS04940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW87_RS04945	COG0571	ribonuclease III activity
HUW87_RS04950	COG1196	nuclear chromosome segregation
HUW87_RS04955	COG0552	protein localization to endoplasmic reticulum
HUW87_RS04960	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HUW87_RS04965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUW87_RS04985	COG0228	four-way junction DNA binding
HUW87_RS04990	COG0582	viral genome integration into host DNA
HUW87_RS05070	COG0629	single-stranded DNA binding
HUW87_RS05095	COG2801	Transposase and inactivated derivatives
HUW87_RS05165	COG0588	phosphoglycerate mutase activity
HUW87_RS05170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUW87_RS05175	COG0336	Belongs to the RNA methyltransferase TrmD family
HUW87_RS05180	COG0335	large ribosomal subunit rRNA binding
HUW87_RS05190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUW87_RS05195	COG1942	4-Oxalocrotonate Tautomerase
HUW87_RS05200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUW87_RS05210	COG1428	Deoxynucleoside kinase
HUW87_RS05215	COG1970	mechanosensitive ion channel activity
HUW87_RS05220	COG0561	phosphatase activity
HUW87_RS05285	COG3853	Toxic anion resistance protein (TelA)
HUW87_RS05290	COG1393	Belongs to the ArsC family
HUW87_RS05295	COG4862	establishment of competence for transformation
HUW87_RS05300	COG2723	6-phospho-beta-galactosidase activity
HUW87_RS05305	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUW87_RS05310	COG1447	Phosphotransferase system cellobiose-specific component IIA
HUW87_RS05315	COG2723	6-phospho-beta-galactosidase activity
HUW87_RS05330	COG2801	Transposase and inactivated derivatives
HUW87_RS05345	COG1164	Oligoendopeptidase f
HUW87_RS05350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUW87_RS05365	COG1609	Transcriptional regulator
HUW87_RS05370	COG0006	proline dipeptidase activity
HUW87_RS05450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUW87_RS05455	COG3425	synthase
HUW87_RS05470	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUW87_RS05475	COG0124	histidyl-tRNA synthetase
HUW87_RS05480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUW87_RS05495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUW87_RS05500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUW87_RS05505	COG1610	YqeY-like protein
HUW87_RS05510	COG1702	phosphate starvation-inducible protein PhoH
HUW87_RS05515	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUW87_RS05520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HUW87_RS05525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUW87_RS05530	COG1381	Involved in DNA repair and RecF pathway recombination
HUW87_RS05550	COG0752	glycyl-tRNA synthetase alpha subunit
HUW87_RS05555	COG0751	glycine-tRNA ligase activity
HUW87_RS05575	COG2706	6-phosphogluconolactonase activity
HUW87_RS05580	COG0628	permease
HUW87_RS05590	COG1674	ftsk spoiiie
HUW87_RS05600	COG4152	abc transporter atp-binding protein
HUW87_RS05605	COG1668	transmembrane transport
HUW87_RS05615	COG0322	excinuclease ABC activity
HUW87_RS05625	COG1739	Uncharacterized protein family UPF0029
HUW87_RS05640	COG0516	GMP reductase activity
HUW87_RS05640	COG0517	IMP dehydrogenase activity
HUW87_RS05645	COG0516	GMP reductase activity
HUW87_RS05645	COG0517	IMP dehydrogenase activity
HUW87_RS05650	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HUW87_RS05655	COG0632	four-way junction helicase activity
HUW87_RS05660	COG2255	four-way junction helicase activity
HUW87_RS05665	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUW87_RS05700	COG0343	queuine tRNA-ribosyltransferase activity
HUW87_RS05705	COG1862	Preprotein translocase
HUW87_RS05710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUW87_RS05715	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUW87_RS05720	COG0513	Belongs to the DEAD box helicase family
HUW87_RS05725	COG1929	Belongs to the glycerate kinase type-1 family
HUW87_RS05730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUW87_RS05750	COG3906	Belongs to the UPF0473 family
HUW87_RS05770	COG1466	dna polymerase III delta subunit
HUW87_RS05775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUW87_RS05780	COG0268	Binds directly to 16S ribosomal RNA
HUW87_RS05805	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUW87_RS05810	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUW87_RS05815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUW87_RS05835	COG1193	negative regulation of DNA recombination
HUW87_RS05860	COG3118	belongs to the thioredoxin family
HUW87_RS05865	COG0187	DNA topoisomerase II activity
HUW87_RS05870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUW87_RS05875	COG3527	Alpha-acetolactate decarboxylase
HUW87_RS05880	COG1473	amidohydrolase
HUW87_RS05895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW87_RS05920	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HUW87_RS05925	COG3201	nicotinamide mononucleotide transporter
HUW87_RS05960	COG0028	Belongs to the TPP enzyme family
HUW87_RS05965	COG2801	Transposase and inactivated derivatives
HUW87_RS06025	COG0277	FAD linked oxidase domain protein
HUW87_RS06030	COG0436	Aminotransferase
HUW87_RS06045	COG1464	Belongs to the NlpA lipoprotein family
HUW87_RS06060	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HUW87_RS06065	COG0351	phosphomethylpyrimidine kinase
HUW87_RS06070	COG0352	thiamine-phosphate diphosphorylase activity
HUW87_RS06090	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_RS06100	COG1940	carbohydrate kinase activity
HUW87_RS06180	COG0546	phosphoglycolate phosphatase activity
HUW87_RS06185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HUW87_RS06190	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUW87_RS06205	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HUW87_RS06210	COG1518	maintenance of DNA repeat elements
HUW87_RS06215	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HUW87_RS06230	COG2357	RelA SpoT domain protein
HUW87_RS06235	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUW87_RS06240	COG0564	pseudouridine synthase activity
HUW87_RS06245	COG2239	Acts as a magnesium transporter
HUW87_RS06255	COG0456	acetyltransferase
HUW87_RS06310	COG2801	Transposase and inactivated derivatives
HUW87_RS06325	COG2207	Transcriptional regulator
HUW87_RS06325	COG4753	response regulator
HUW87_RS06335	COG0384	phenazine biosynthesis protein PhzF
HUW87_RS06345	COG1621	beta-fructofuranosidase activity
HUW87_RS06365	COG1033	growth of symbiont in host cell
HUW87_RS06365	COG2409	Drug exporters of the RND superfamily
HUW87_RS06370	COG4684	Psort location CytoplasmicMembrane, score
HUW87_RS06385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUW87_RS06390	COG0738	Major facilitator superfamily
HUW87_RS06395	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUW87_RS06425	COG1304	FMN binding
HUW87_RS06440	COG0779	Required for maturation of 30S ribosomal subunits
HUW87_RS06445	COG0195	Participates in both transcription termination and antitermination
HUW87_RS06450	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HUW87_RS06460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUW87_RS06465	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUW87_RS06470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUW87_RS06485	COG0196	riboflavin kinase activity
HUW87_RS06490	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HUW87_RS06495	COG3142	Participates in the control of copper homeostasis
HUW87_RS06510	COG2270	Major facilitator Superfamily
HUW87_RS06515	COG1307	EDD domain protein, DegV family
HUW87_RS06520	COG1307	EDD domain protein, DegV family
HUW87_RS06525	COG2755	lipolytic protein G-D-S-L family
HUW87_RS06535	COG4479	Belongs to the UPF0346 family
HUW87_RS06545	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUW87_RS06555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUW87_RS06560	COG4974	Belongs to the 'phage' integrase family
HUW87_RS06570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUW87_RS06590	COG3448	diguanylate cyclase activity
HUW87_RS06590	COG4175	Glycine betaine
HUW87_RS06605	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUW87_RS06610	COG1464	Belongs to the NlpA lipoprotein family
HUW87_RS06615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW87_RS06620	COG1597	lipid kinase activity
HUW87_RS06625	COG1011	Hydrolase
HUW87_RS06645	COG5503	Protein of unknown function (DUF1447)
HUW87_RS06660	COG0242	peptide deformylase activity
HUW87_RS06665	COG4476	Belongs to the UPF0223 family
HUW87_RS06670	COG0483	inositol monophosphate 1-phosphatase activity
HUW87_RS06675	COG1217	gtp-binding protein TYPA
HUW87_RS06680	COG0772	Belongs to the SEDS family
HUW87_RS06685	COG4471	UPF0298 protein
HUW87_RS06690	COG0742	ribosomal rna small subunit methyltransferase
HUW87_RS06695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUW87_RS06700	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUW87_RS06705	COG0477	Major facilitator Superfamily
HUW87_RS06715	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HUW87_RS06720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUW87_RS06725	COG0358	DNA primase activity
HUW87_RS06730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUW87_RS06760	COG0745	RESPONSE REGULATOR receiver
HUW87_RS06765	COG5002	protein histidine kinase activity
HUW87_RS06770	COG0572	uridine kinase
HUW87_RS06775	COG1363	Peptidase, m42
HUW87_RS06780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUW87_RS06790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUW87_RS06795	COG0670	Belongs to the BI1 family
HUW87_RS06800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW87_RS06800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUW87_RS06805	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUW87_RS06810	COG0237	dephospho-CoA kinase activity
HUW87_RS06820	COG1484	DNA-dependent DNA replication
HUW87_RS06835	COG0745	RESPONSE REGULATOR receiver
HUW87_RS06840	COG5002	protein histidine kinase activity
HUW87_RS06850	COG3942	CHAP domain
HUW87_RS06850	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUW87_RS06855	COG2801	Transposase and inactivated derivatives
HUW87_RS06885	COG0706	membrane insertase activity
HUW87_RS06890	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_RS06895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUW87_RS06905	COG1304	FMN binding
HUW87_RS06925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUW87_RS06925	COG1199	ATP-dependent helicase activity
HUW87_RS06935	COG0017	Asparaginyl-tRNA synthetase
HUW87_RS06940	COG3935	DnaD domain protein
HUW87_RS06950	COG3331	DNA recombination
HUW87_RS06955	COG4474	Belongs to the UPF0398 family
HUW87_RS06960	COG3599	regulation of cell shape
HUW87_RS06970	COG0116	Belongs to the methyltransferase superfamily
HUW87_RS06980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUW87_RS07000	COG0556	nucleotide-excision repair
HUW87_RS07010	COG0439	Biotin carboxylase
HUW87_RS07020	COG3104	oligopeptide transport
HUW87_RS07025	COG0363	glucosamine-6-phosphate deaminase activity
HUW87_RS07035	COG2801	Transposase and inactivated derivatives
HUW87_RS07050	COG0537	adenosine 5'-monophosphoramidase activity
HUW87_RS07055	COG1131	(ABC) transporter
HUW87_RS07065	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUW87_RS07070	COG1719	4-vinyl reductase, 4VR
HUW87_RS07075	COG1397	ADP-ribosylglycohydrolase
HUW87_RS07085	COG2801	Transposase and inactivated derivatives
HUW87_RS07115	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUW87_RS07120	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HUW87_RS07125	COG1349	DNA-binding transcription factor activity
HUW87_RS07130	COG1105	Belongs to the carbohydrate kinase PfkB family
HUW87_RS07135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUW87_RS07135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUW87_RS07135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUW87_RS07145	COG1609	Transcriptional regulator
HUW87_RS07155	COG0306	phosphate transporter
HUW87_RS07170	COG2723	6-phospho-beta-galactosidase activity
HUW87_RS07190	COG0531	amino acid
HUW87_RS07200	COG0481	GTPase activity
HUW87_RS07235	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_RS07240	COG4708	membrane
HUW87_RS07250	COG0531	amino acid
HUW87_RS07255	COG4221	oxidoreductase activity
HUW87_RS07275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW87_RS07290	COG1136	(ABC) transporter
HUW87_RS07295	COG0577	efflux transmembrane transporter activity
HUW87_RS07305	COG2801	Transposase and inactivated derivatives
HUW87_RS07315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUW87_RS07325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUW87_RS07330	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUW87_RS07360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUW87_RS07365	COG2384	SAM-dependent methyltransferase
HUW87_RS07370	COG0071	Belongs to the small heat shock protein (HSP20) family
HUW87_RS07375	COG0457	Tetratricopeptide repeat
HUW87_RS07420	COG0419	ATPase involved in DNA repair
HUW87_RS07425	COG0420	3'-5' exonuclease activity
HUW87_RS07435	COG2807	transmembrane transport
HUW87_RS07440	COG4720	Psort location CytoplasmicMembrane, score
HUW87_RS07445	COG0351	phosphomethylpyrimidine kinase
HUW87_RS07455	COG1160	GTP binding
HUW87_RS07460	COG0539	negative regulation of cytoplasmic translation
HUW87_RS07465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUW87_RS07475	COG0514	ATP-dependent DNA helicase (RecQ)
HUW87_RS07485	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HUW87_RS07500	COG1187	pseudouridine synthase activity
HUW87_RS07505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUW87_RS07510	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUW87_RS07525	COG2996	Protein conserved in bacteria
HUW87_RS07535	COG0475	glutathione-regulated potassium exporter activity
HUW87_RS07545	COG1490	D-aminoacyl-tRNA deacylase activity
HUW87_RS07550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUW87_RS07555	COG0587	DNA-directed DNA polymerase activity
HUW87_RS07565	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUW87_RS07570	COG0488	(ABC) transporter
HUW87_RS07575	COG0617	tRNA 3'-terminal CCA addition
HUW87_RS07585	COG2801	Transposase and inactivated derivatives
HUW87_RS07590	COG1136	(ABC) transporter
HUW87_RS07605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUW87_RS07610	COG0004	ammonium transporteR
HUW87_RS07620	COG0366	Alpha amylase catalytic
HUW87_RS07620	COG5263	repeat protein
HUW87_RS07625	COG1316	TRANSCRIPTIONal
HUW87_RS07630	COG1216	Glycosyl transferase, family 2
HUW87_RS07645	COG1216	Glycosyl transferase, family 2
HUW87_RS07655	COG0438	transferase activity, transferring glycosyl groups
HUW87_RS07660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUW87_RS07665	COG0489	protein tyrosine kinase activity
HUW87_RS07680	COG0233	cytoplasmic translational termination
HUW87_RS07690	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUW87_RS07695	COG0052	Belongs to the universal ribosomal protein uS2 family
HUW87_RS07700	COG2827	Endonuclease containing a URI domain
HUW87_RS07705	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUW87_RS07710	COG0204	Acyl-transferase
HUW87_RS07715	COG0791	NLP P60 protein
HUW87_RS07715	COG3883	PFAM NLP P60 protein
HUW87_RS07730	COG3763	UPF0154 protein
HUW87_RS07735	COG4224	UPF0291 protein
HUW87_RS07740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUW87_RS07760	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HUW87_RS07760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUW87_RS07765	COG1234	tRNA 3'-trailer cleavage
HUW87_RS07780	COG0484	heat shock protein binding
HUW87_RS07785	COG0443	Heat shock 70 kDa protein
HUW87_RS07795	COG1420	regulation of RNA biosynthetic process
HUW87_RS07825	COG1216	Glycosyl transferase, family 2
HUW87_RS07835	COG0463	Glycosyl transferase, family 2
HUW87_RS07845	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUW87_RS07860	COG0562	UDP-galactopyranose mutase
HUW87_RS07885	COG0024	Methionine aminopeptidase
HUW87_RS07905	COG1388	LysM domain
HUW87_RS07905	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUW87_RS07935	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUW87_RS07945	COG1682	transport, permease protein
HUW87_RS07950	COG1134	teichoic acid transport
HUW87_RS07950	COG1388	LysM domain
HUW87_RS07955	COG1063	alcohol dehydrogenase
HUW87_RS07960	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUW87_RS07965	COG3475	LICD family
HUW87_RS07985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW87_RS08015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUW87_RS08130	COG0463	Glycosyl transferase, family 2
HUW87_RS08145	COG3706	GGDEF domain
HUW87_RS08160	COG2801	Transposase and inactivated derivatives
HUW87_RS08215	COG2309	aminopeptidase activity
HUW87_RS08230	COG0564	pseudouridine synthase activity
HUW87_RS08235	COG1278	Cold shock
HUW87_RS08245	COG2814	Major facilitator Superfamily
HUW87_RS08250	COG0741	lytic transglycosylase activity
HUW87_RS08260	COG3973	AAA domain
HUW87_RS08270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUW87_RS08275	COG1058	Belongs to the CinA family
HUW87_RS08275	COG1546	Belongs to the CinA family
HUW87_RS08280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUW87_RS08285	COG1426	Protein conserved in bacteria
HUW87_RS08290	COG0612	Peptidase, M16
HUW87_RS08295	COG0612	Peptidase, M16
HUW87_RS08310	COG0028	Belongs to the TPP enzyme family
HUW87_RS08330	COG4717	serine-type aminopeptidase activity
HUW87_RS08340	COG3679	Belongs to the UPF0342 family
HUW87_RS08345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUW87_RS08350	COG1438	arginine binding
HUW87_RS08370	COG0018	arginyl-trna synthetase
HUW87_RS08385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUW87_RS08395	COG1121	(ABC) transporter
HUW87_RS08415	COG1597	lipid kinase activity
HUW87_RS08420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW87_RS08425	COG0154	amidase activity
HUW87_RS08430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUW87_RS08435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUW87_RS08435	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HUW87_RS08445	COG2936	dipeptidyl-peptidase activity
HUW87_RS08460	COG1695	Transcriptional regulator
HUW87_RS08470	COG1914	H( )-stimulated, divalent metal cation uptake system
HUW87_RS08490	COG0667	Aldo Keto reductase
HUW87_RS08495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUW87_RS08500	COG4721	ABC-type cobalt transport system, permease component
HUW87_RS08505	COG1122	ATPase activity
HUW87_RS08520	COG0710	3-dehydroquinate dehydratase activity
HUW87_RS08525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUW87_RS08530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUW87_RS08535	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUW87_RS08540	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUW87_RS08545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HUW87_RS08550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUW87_RS08565	COG4684	Psort location CytoplasmicMembrane, score
HUW87_RS08570	COG0436	Aminotransferase
HUW87_RS08690	COG1783	phage Terminase large subunit
HUW87_RS08780	COG0629	single-stranded DNA binding
HUW87_RS08840	COG1396	sequence-specific DNA binding
HUW87_RS08860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUW87_RS08865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUW87_RS08870	COG0436	Aminotransferase
HUW87_RS08875	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUW87_RS08880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUW87_RS08890	COG2171	N-acyltransferase activity
HUW87_RS08895	COG0019	diaminopimelate decarboxylase activity
HUW87_RS08900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUW87_RS08905	COG0527	aspartate kinase activity
HUW87_RS08915	COG1609	Transcriptional regulator
HUW87_RS08920	COG0083	homoserine kinase activity
HUW87_RS08935	COG1321	iron dependent repressor
HUW87_RS08940	COG3764	Sortase (surface protein transpeptidase)
HUW87_RS08960	COG0513	Belongs to the DEAD box helicase family
HUW87_RS08965	COG0673	inositol 2-dehydrogenase activity
HUW87_RS08970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW87_RS08980	COG2801	Transposase and inactivated derivatives
HUW87_RS08990	COG0501	Belongs to the peptidase M48B family
HUW87_RS08995	COG1704	LemA family
HUW87_RS09005	COG4115	mRNA cleavage
HUW87_RS09010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW87_RS09025	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HUW87_RS09035	COG0439	Biotin carboxylase
HUW87_RS09050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUW87_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_RS09060	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HUW87_RS09065	COG2070	2-Nitropropane dioxygenase
HUW87_RS09070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUW87_RS09075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW87_RS09080	COG1846	Transcriptional regulator
HUW87_RS09085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUW87_RS09095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUW87_RS09100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUW87_RS09110	COG0505	Belongs to the CarA family
HUW87_RS09120	COG0564	pseudouridine synthase activity
HUW87_RS09130	COG0328	RNA-DNA hybrid ribonuclease activity
HUW87_RS09135	COG1757	Na H antiporter
HUW87_RS09140	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HUW87_RS09145	COG1113	amino acid transport
HUW87_RS09160	COG2801	Transposase and inactivated derivatives
HUW87_RS09260	COG2801	Transposase and inactivated derivatives
HUW87_RS09275	COG1396	sequence-specific DNA binding
HUW87_RS09295	COG4974	Belongs to the 'phage' integrase family
HUW87_RS09310	COG0656	L-ascorbic acid biosynthetic process
HUW87_RS09320	COG1012	belongs to the aldehyde dehydrogenase family
HUW87_RS09320	COG1454	alcohol dehydrogenase
HUW87_RS09325	COG0105	UTP biosynthetic process
HUW87_RS09335	COG0583	DNA-binding transcription factor activity
HUW87_RS09340	COG0126	phosphoglycerate kinase activity
HUW87_RS09390	COG0588	phosphoglycerate mutase activity
HUW87_RS09400	COG3716	PTS system mannose fructose sorbose family IID component
HUW87_RS09405	COG3715	PTS system
HUW87_RS09425	COG2801	Transposase and inactivated derivatives
HUW87_RS09430	COG1397	ADP-ribosylglycohydrolase
HUW87_RS09490	COG1368	sulfuric ester hydrolase activity
HUW87_RS09505	COG0438	transferase activity, transferring glycosyl groups
HUW87_RS09510	COG0438	transferase activity, transferring glycosyl groups
HUW87_RS09515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUW87_RS09520	COG0284	orotidine-5'-phosphate decarboxylase activity
HUW87_RS09525	COG0167	dihydroorotate dehydrogenase activity
HUW87_RS09530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUW87_RS09535	COG0505	Belongs to the CarA family
HUW87_RS09540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUW87_RS09545	COG0540	Belongs to the ATCase OTCase family
HUW87_RS09560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUW87_RS09565	COG4856	YbbR-like protein
HUW87_RS09580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUW87_RS09585	COG2176	DNA-directed DNA polymerase activity
HUW87_RS09595	COG0802	atpase or kinase
HUW87_RS09600	COG0280	phosphate acetyltransferase
HUW87_RS09605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUW87_RS09615	COG2076	Multidrug Resistance protein
HUW87_RS09620	COG2076	Multidrug Resistance protein
HUW87_RS09625	COG1126	abc transporter atp-binding protein
HUW87_RS09630	COG0765	amino acid transport
HUW87_RS09635	COG2814	Major facilitator Superfamily
HUW87_RS09650	COG0557	exoribonuclease II activity
HUW87_RS09660	COG2814	Major facilitator Superfamily
HUW87_RS09665	COG0154	amidase activity
HUW87_RS09685	COG0149	triose-phosphate isomerase activity
HUW87_RS09690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUW87_RS09695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUW87_RS09705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUW87_RS09710	COG0492	ferredoxin-NADP+ reductase activity
HUW87_RS09730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUW87_RS09735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUW87_RS09740	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HUW87_RS09745	COG1950	PFAM Membrane protein of
HUW87_RS09755	COG0589	response to stress
HUW87_RS09765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUW87_RS09775	COG1177	transmembrane transport
HUW87_RS09785	COG3842	ATPase activity
HUW87_RS09795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUW87_RS09800	COG0049	tRNA binding
HUW87_RS09805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUW87_RS09810	COG4608	Belongs to the ABC transporter superfamily
HUW87_RS09815	COG0444	Belongs to the ABC transporter superfamily
HUW87_RS09820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW87_RS09825	COG0601	transmembrane transport
HUW87_RS09840	COG0460	homoserine dehydrogenase
HUW87_RS09845	COG0626	cystathionine gamma-synthase activity
HUW87_RS09850	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HUW87_RS09860	COG1744	ABC transporter substrate-binding protein PnrA-like
HUW87_RS09870	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUW87_RS09885	COG1302	Protein conserved in bacteria
HUW87_RS09890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUW87_RS09900	COG2017	converts alpha-aldose to the beta-anomer
HUW87_RS09910	COG4975	Glucose uptake
HUW87_RS09915	COG2801	Transposase and inactivated derivatives
HUW87_RS09925	COG3850	Histidine kinase
HUW87_RS09925	COG5002	protein histidine kinase activity
HUW87_RS09930	COG0745	RESPONSE REGULATOR receiver
HUW87_RS09935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUW87_RS09940	COG0402	S-adenosylhomocysteine deaminase activity
HUW87_RS09945	COG0673	inositol 2-dehydrogenase activity
HUW87_RS09950	COG0741	lytic transglycosylase activity
HUW87_RS09970	COG0668	transmembrane transport
HUW87_RS09980	COG1126	abc transporter atp-binding protein
HUW87_RS09985	COG0765	amino acid transport
HUW87_RS10025	COG0516	GMP reductase activity
HUW87_RS10105	COG2801	Transposase and inactivated derivatives
HUW87_RS10135	COG0738	Major facilitator superfamily
HUW87_RS10140	COG1869	D-ribose catabolic process
HUW87_RS10145	COG1609	Transcriptional regulator
HUW87_RS10165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUW87_RS10180	COG1609	Transcriptional regulator
HUW87_RS10195	COG2223	nitrite transmembrane transporter activity
HUW87_RS10205	COG0318	PFAM AMP-dependent synthetase and ligase
HUW87_RS10215	COG1116	anion transmembrane transporter activity
HUW87_RS10220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUW87_RS10230	COG0285	dihydrofolate synthase activity
HUW87_RS10235	COG0302	gtp cyclohydrolase
HUW87_RS10240	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUW87_RS10240	COG0302	gtp cyclohydrolase
HUW87_RS10255	COG0561	phosphatase activity
HUW87_RS10265	COG0823	Involved in the tonB-independent uptake of proteins
HUW87_RS10265	COG1506	peptidase
HUW87_RS10265	COG4946	Tricorn protease homolog
HUW87_RS10270	COG1464	Belongs to the NlpA lipoprotein family
HUW87_RS10285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUW87_RS10300	COG1609	Transcriptional regulator
HUW87_RS10330	COG0577	efflux transmembrane transporter activity
HUW87_RS10335	COG1136	(ABC) transporter
HUW87_RS10340	COG3759	membrane
HUW87_RS10370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUW87_RS10375	COG2235	arginine
HUW87_RS10385	COG2217	Heavy metal translocating P-type atpase
HUW87_RS10435	COG0438	transferase activity, transferring glycosyl groups
HUW87_RS10480	COG2814	Major facilitator Superfamily
HUW87_RS10485	COG2217	Heavy metal translocating P-type atpase
HUW87_RS10505	COG1309	transcriptional regulator
HUW87_RS10525	COG3711	transcriptional antiterminator
HUW87_RS10530	COG2723	6-phospho-beta-galactosidase activity
HUW87_RS10535	COG1940	carbohydrate kinase activity
HUW87_RS10560	COG2183	response to ionizing radiation
HUW87_RS10570	COG2873	o-acetylhomoserine
HUW87_RS10575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUW87_RS10580	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HUW87_RS10665	COG2176	DNA-directed DNA polymerase activity
HUW87_RS10670	COG0442	prolyl-tRNA aminoacylation
HUW87_RS10675	COG0750	zinc metalloprotease
HUW87_RS10680	COG4589	Belongs to the CDS family
HUW87_RS10685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUW87_RS10690	COG0561	phosphatase activity
HUW87_RS10695	COG2246	polysaccharide biosynthetic process
HUW87_RS10720	COG1811	Na channel or pump
HUW87_RS10725	COG1979	alcohol dehydrogenase
HUW87_RS10735	COG1174	glycine betaine transport
HUW87_RS10755	COG2801	Transposase and inactivated derivatives
HUW87_RS10770	COG1307	EDD domain protein, DegV family
HUW87_RS10775	COG0656	L-ascorbic acid biosynthetic process
HUW87_RS10780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUW87_RS10800	COG1228	amidohydrolase
HUW87_RS10805	COG4166	transmembrane transport
HUW87_RS10825	COG2826	transposase and inactivated derivatives, IS30 family
HUW87_RS10865	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HUW87_RS10870	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUW87_RS10880	COG2252	PERMEase
HUW87_RS10890	COG0352	thiamine-phosphate diphosphorylase activity
HUW87_RS10895	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HUW87_RS10905	COG2814	Major facilitator Superfamily
HUW87_RS10910	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUW87_RS10925	COG2188	Transcriptional regulator
HUW87_RS10935	COG0577	efflux transmembrane transporter activity
HUW87_RS10935	COG1136	(ABC) transporter
HUW87_RS10945	COG0561	phosphatase activity
HUW87_RS10950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUW87_RS10950	COG2169	Transcriptional regulator
HUW87_RS10955	COG0561	phosphatase activity
HUW87_RS10975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUW87_RS10980	COG0772	Belongs to the SEDS family
HUW87_RS10990	COG1077	Cell shape determining protein MreB Mrl
HUW87_RS10995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUW87_RS11000	COG1079	Belongs to the binding-protein-dependent transport system permease family
HUW87_RS11005	COG4603	Belongs to the binding-protein-dependent transport system permease family
HUW87_RS11010	COG3845	ABC transporter
HUW87_RS11015	COG1744	ABC transporter substrate-binding protein PnrA-like
HUW87_RS11020	COG2801	Transposase and inactivated derivatives
HUW87_RS11040	COG0640	Transcriptional regulator
HUW87_RS11045	COG0628	permease
HUW87_RS11050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUW87_RS11070	COG0386	Belongs to the glutathione peroxidase family
HUW87_RS11075	COG0588	phosphoglycerate mutase activity
HUW87_RS11090	COG0492	ferredoxin-NADP+ reductase activity
HUW87_RS11105	COG1744	ABC transporter substrate-binding protein PnrA-like
HUW87_RS11110	COG1744	ABC transporter substrate-binding protein PnrA-like
HUW87_RS11115	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUW87_RS11120	COG2832	Protein of unknown function (DUF454)
HUW87_RS11145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUW87_RS11155	COG2814	Major facilitator Superfamily
HUW87_RS11160	COG0305	Participates in initiation and elongation during chromosome replication
HUW87_RS11165	COG0359	binds to the 23S rRNA
HUW87_RS11175	COG4608	Belongs to the ABC transporter superfamily
HUW87_RS11180	COG0444	Belongs to the ABC transporter superfamily
HUW87_RS11185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUW87_RS11190	COG0601	transmembrane transport
HUW87_RS11195	COG4166	transmembrane transport
HUW87_RS11200	COG0765	amino acid transport
HUW87_RS11205	COG0765	amino acid transport
HUW87_RS11210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW87_RS11215	COG1126	abc transporter atp-binding protein
HUW87_RS11230	COG0194	GDP metabolic process
HUW87_RS11235	COG1268	BioY protein
HUW87_RS11240	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HUW87_RS11240	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HUW87_RS11270	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUW87_RS11285	COG3973	AAA domain
HUW87_RS11305	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HUW87_RS11315	COG1696	Membrane protein involved in D-alanine export
HUW87_RS11335	COG2337	Toxic component of a toxin-antitoxin (TA) module
HUW87_RS11350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUW87_RS11355	COG0504	CTP synthase activity
HUW87_RS11365	COG3343	RNA polymerase activity
HUW87_RS11370	COG0561	phosphatase activity
HUW87_RS11375	COG1078	dGTPase activity
HUW87_RS11385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUW87_RS11390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HUW87_RS11410	COG0745	RESPONSE REGULATOR receiver
HUW87_RS11440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUW87_RS11445	COG0629	single-stranded DNA binding
HUW87_RS11450	COG0360	Binds together with S18 to 16S ribosomal RNA
HUW87_RS11465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUW87_RS11475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUW87_RS11480	COG1051	belongs to the nudix hydrolase family
HUW87_RS11495	COG2814	Major facilitator Superfamily
HUW87_RS11500	COG1064	alcohol dehydrogenase
HUW87_RS11505	COG1074	ATP-dependent DNA helicase activity
HUW87_RS11510	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HUW87_RS11525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUW87_RS11530	COG0531	amino acid
HUW87_RS11535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUW87_RS11545	COG1902	pentaerythritol trinitrate reductase activity
HUW87_RS11550	COG0626	cystathionine gamma-synthase activity
HUW87_RS11570	COG2244	polysaccharide biosynthetic process
HUW87_RS11580	COG0438	transferase activity, transferring glycosyl groups
HUW87_RS11585	COG0495	leucyl-tRNA aminoacylation
HUW87_RS11590	COG0671	phosphoesterase, PA-phosphatase related
HUW87_RS11600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUW87_RS11625	COG2723	6-phospho-beta-galactosidase activity
HUW87_RS11645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUW87_RS11660	COG0024	Methionine aminopeptidase
HUW87_RS11670	COG1316	TRANSCRIPTIONal
HUW87_RS11680	COG2205	protein histidine kinase activity
HUW87_RS11685	COG0745	RESPONSE REGULATOR receiver
HUW87_RS11690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUW87_RS11705	COG2207	Transcriptional regulator
HUW87_RS11725	COG0308	aminopeptidase N
HUW87_RS11730	COG0833	amino acid
HUW87_RS11735	COG2040	homocysteine
HUW87_RS11740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUW87_RS11745	COG0542	response to heat
HUW87_RS11750	COG0308	aminopeptidase N
HUW87_RS11765	COG0395	ABC-type sugar transport system, permease component
HUW87_RS11770	COG1175	transmembrane transport
HUW87_RS11775	COG3842	ATPase activity
HUW87_RS11790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW87_RS11825	COG2814	Major facilitator Superfamily
HUW87_RS11850	COG1914	H( )-stimulated, divalent metal cation uptake system
HUW87_RS11910	COG0438	transferase activity, transferring glycosyl groups
HUW87_RS11945	COG2084	Dehydrogenase
HUW87_RS11950	COG1028	Short-chain dehydrogenase reductase Sdr
HUW87_RS11960	COG1620	l-lactate permease
HUW87_RS11965	COG4989	oxidoreductase activity
HUW87_RS11970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUW87_RS11975	COG2233	PERMEase
HUW87_RS12015	COG0783	Belongs to the Dps family
HUW87_RS12020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUW87_RS12045	COG2261	transglycosylase associated protein
HUW87_RS12065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUW87_RS12075	COG0492	ferredoxin-NADP+ reductase activity
HUW87_RS12085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUW87_RS12090	COG3118	belongs to the thioredoxin family
HUW87_RS12095	COG0640	Transcriptional regulator
HUW87_RS12105	COG1454	alcohol dehydrogenase
HUW87_RS12105	COG1012	belongs to the aldehyde dehydrogenase family
HUW87_RS12115	COG1573	uracil-dna glycosylase
HUW87_RS12145	COG2017	converts alpha-aldose to the beta-anomer
HUW87_RS12225	COG0366	Alpha amylase catalytic
HUW87_RS12225	COG5263	repeat protein
HUW87_RS12240	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HUW87_RS12280	COG1063	alcohol dehydrogenase