locus-tag	class	description
B6254_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B6254_RS00010	COG0592	DNA-directed DNA polymerase activity
B6254_RS00015	COG2501	S4 domain
B6254_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6254_RS00025	COG0187	DNA topoisomerase II activity
B6254_RS00040	COG2153	protein acetylation
B6254_RS00045	COG1368	sulfuric ester hydrolase activity
B6254_RS00065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B6254_RS00130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6254_RS00130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6254_RS00140	COG0084	hydrolase, TatD family'
B6254_RS00145	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B6254_RS00150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6254_RS00155	COG1253	flavin adenine dinucleotide binding
B6254_RS00160	COG1253	flavin adenine dinucleotide binding
B6254_RS00165	COG4466	Protein conserved in bacteria
B6254_RS00170	COG2131	deaminase
B6254_RS00180	COG1316	TRANSCRIPTIONal
B6254_RS00185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6254_RS00185	COG1263	PTS System
B6254_RS00190	COG2723	6-phospho-beta-galactosidase activity
B6254_RS00200	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B6254_RS00215	COG0737	Belongs to the 5'-nucleotidase family
B6254_RS00220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B6254_RS00225	COG1983	PspC domain protein
B6254_RS00230	COG1695	Transcriptional regulator
B6254_RS00245	COG1968	undecaprenyl-diphosphatase activity
B6254_RS00250	COG2818	Glycosylase
B6254_RS00275	COG3507	Belongs to the glycosyl hydrolase 43 family
B6254_RS00280	COG2211	Major facilitator Superfamily
B6254_RS00290	COG2115	Belongs to the xylose isomerase family
B6254_RS00300	COG0667	Aldo Keto reductase
B6254_RS00315	COG0477	Major facilitator Superfamily
B6254_RS00320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6254_RS00335	COG1309	transcriptional regulator
B6254_RS00340	COG1511	domain protein
B6254_RS00340	COG1511	domain protein
B6254_RS00355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B6254_RS00360	COG0297	glycogen (starch) synthase activity
B6254_RS00365	COG0058	SHG alpha-glucan phosphorylase activity
B6254_RS00375	COG0193	aminoacyl-tRNA hydrolase activity
B6254_RS00380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B6254_RS00385	COG2244	polysaccharide biosynthetic process
B6254_RS00390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B6254_RS00400	COG0037	tRNA processing
B6254_RS00415	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B6254_RS00420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B6254_RS00485	COG2261	transglycosylase associated protein
B6254_RS00490	COG0656	L-ascorbic acid biosynthetic process
B6254_RS00500	COG1737	Transcriptional regulator
B6254_RS00505	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B6254_RS00540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B6254_RS00555	COG1216	Glycosyl transferase, family 2
B6254_RS00570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B6254_RS00575	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6254_RS00580	COG1447	Phosphotransferase system cellobiose-specific component IIA
B6254_RS00585	COG2723	6-phospho-beta-galactosidase activity
B6254_RS00590	COG2723	6-phospho-beta-galactosidase activity
B6254_RS00595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6254_RS00605	COG0436	Aminotransferase
B6254_RS00610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B6254_RS00625	COG2211	Major facilitator Superfamily
B6254_RS00625	COG2190	(PTS) system
B6254_RS00630	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B6254_RS00635	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B6254_RS00640	COG0444	Belongs to the ABC transporter superfamily
B6254_RS00645	COG4608	Belongs to the ABC transporter superfamily
B6254_RS00650	COG0601	transmembrane transport
B6254_RS00655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6254_RS00660	COG0747	negative chemotaxis
B6254_RS00665	COG1132	(ABC) transporter
B6254_RS00670	COG1132	(ABC) transporter
B6254_RS00685	COG1956	GAF domain-containing protein
B6254_RS00700	COG2233	PERMEase
B6254_RS00705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B6254_RS00710	COG4989	oxidoreductase activity
B6254_RS00715	COG1620	l-lactate permease
B6254_RS00725	COG1028	Short-chain dehydrogenase reductase Sdr
B6254_RS00730	COG2084	Dehydrogenase
B6254_RS00755	COG0438	transferase activity, transferring glycosyl groups
B6254_RS00870	COG3842	ATPase activity
B6254_RS00875	COG1175	transmembrane transport
B6254_RS00880	COG0395	ABC-type sugar transport system, permease component
B6254_RS00895	COG0542	response to heat
B6254_RS00900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6254_RS00905	COG2040	homocysteine
B6254_RS00910	COG0833	amino acid
B6254_RS00915	COG0308	aminopeptidase N
B6254_RS00935	COG2207	Transcriptional regulator
B6254_RS00950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6254_RS00955	COG0745	RESPONSE REGULATOR receiver
B6254_RS00960	COG2205	protein histidine kinase activity
B6254_RS00970	COG1316	TRANSCRIPTIONal
B6254_RS00980	COG0024	Methionine aminopeptidase
B6254_RS00990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B6254_RS01010	COG2723	6-phospho-beta-galactosidase activity
B6254_RS01035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6254_RS01045	COG0671	phosphoesterase, PA-phosphatase related
B6254_RS01050	COG0495	leucyl-tRNA aminoacylation
B6254_RS01055	COG0438	transferase activity, transferring glycosyl groups
B6254_RS01065	COG2244	polysaccharide biosynthetic process
B6254_RS01085	COG1902	pentaerythritol trinitrate reductase activity
B6254_RS01095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B6254_RS01100	COG0531	amino acid
B6254_RS01105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6254_RS01120	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B6254_RS01125	COG1074	ATP-dependent DNA helicase activity
B6254_RS01130	COG1064	alcohol dehydrogenase
B6254_RS01135	COG2814	Major facilitator Superfamily
B6254_RS01150	COG1051	belongs to the nudix hydrolase family
B6254_RS01155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B6254_RS01165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6254_RS01180	COG0360	Binds together with S18 to 16S ribosomal RNA
B6254_RS01185	COG0629	single-stranded DNA binding
B6254_RS01190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B6254_RS01220	COG0745	RESPONSE REGULATOR receiver
B6254_RS01240	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B6254_RS01245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6254_RS01255	COG1078	dGTPase activity
B6254_RS01260	COG0561	phosphatase activity
B6254_RS01265	COG3343	RNA polymerase activity
B6254_RS01290	COG0504	CTP synthase activity
B6254_RS01295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B6254_RS01310	COG2337	Toxic component of a toxin-antitoxin (TA) module
B6254_RS01330	COG1696	Membrane protein involved in D-alanine export
B6254_RS01340	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B6254_RS01360	COG3973	AAA domain
B6254_RS01375	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B6254_RS01380	COG2211	Major facilitator Superfamily
B6254_RS01405	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B6254_RS01405	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B6254_RS01410	COG1268	BioY protein
B6254_RS01415	COG0194	GDP metabolic process
B6254_RS01430	COG1126	abc transporter atp-binding protein
B6254_RS01435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6254_RS01440	COG0765	amino acid transport
B6254_RS01445	COG0765	amino acid transport
B6254_RS01450	COG4166	transmembrane transport
B6254_RS01455	COG0601	transmembrane transport
B6254_RS01460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6254_RS01465	COG0444	Belongs to the ABC transporter superfamily
B6254_RS01470	COG4608	Belongs to the ABC transporter superfamily
B6254_RS01480	COG0359	binds to the 23S rRNA
B6254_RS01485	COG0305	Participates in initiation and elongation during chromosome replication
B6254_RS01490	COG2814	Major facilitator Superfamily
B6254_RS01500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6254_RS01525	COG2832	Protein of unknown function (DUF454)
B6254_RS01530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B6254_RS01535	COG1744	ABC transporter substrate-binding protein PnrA-like
B6254_RS01540	COG1744	ABC transporter substrate-binding protein PnrA-like
B6254_RS01555	COG0492	ferredoxin-NADP+ reductase activity
B6254_RS01570	COG0588	phosphoglycerate mutase activity
B6254_RS01575	COG0386	Belongs to the glutathione peroxidase family
B6254_RS01595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6254_RS01600	COG0628	permease
B6254_RS01605	COG0640	Transcriptional regulator
B6254_RS01615	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6254_RS01620	COG1744	ABC transporter substrate-binding protein PnrA-like
B6254_RS01625	COG3845	ABC transporter
B6254_RS01630	COG4603	Belongs to the binding-protein-dependent transport system permease family
B6254_RS01635	COG1079	Belongs to the binding-protein-dependent transport system permease family
B6254_RS01640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B6254_RS01645	COG1077	Cell shape determining protein MreB Mrl
B6254_RS01655	COG0772	Belongs to the SEDS family
B6254_RS01660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B6254_RS01690	COG0561	phosphatase activity
B6254_RS01695	COG2169	Transcriptional regulator
B6254_RS01695	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6254_RS01700	COG0561	phosphatase activity
B6254_RS01710	COG0577	efflux transmembrane transporter activity
B6254_RS01710	COG1136	(ABC) transporter
B6254_RS01720	COG2188	Transcriptional regulator
B6254_RS01730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B6254_RS01735	COG2814	Major facilitator Superfamily
B6254_RS01745	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B6254_RS01750	COG0352	thiamine-phosphate diphosphorylase activity
B6254_RS01760	COG2252	PERMEase
B6254_RS01770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B6254_RS01775	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B6254_RS01830	COG4166	transmembrane transport
B6254_RS01835	COG1228	amidohydrolase
B6254_RS01855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B6254_RS01860	COG0656	L-ascorbic acid biosynthetic process
B6254_RS01865	COG1307	EDD domain protein, DegV family
B6254_RS01880	COG1435	thymidine kinase activity
B6254_RS01885	COG2076	Multidrug Resistance protein
B6254_RS01890	COG2076	Multidrug Resistance protein
B6254_RS01895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B6254_RS01895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B6254_RS01900	COG0307	riboflavin synthase, alpha
B6254_RS01905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6254_RS01905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6254_RS01910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B6254_RS01930	COG1174	glycine betaine transport
B6254_RS01940	COG1979	alcohol dehydrogenase
B6254_RS01945	COG1811	Na channel or pump
B6254_RS01970	COG2246	polysaccharide biosynthetic process
B6254_RS01975	COG0561	phosphatase activity
B6254_RS01980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6254_RS01985	COG4589	Belongs to the CDS family
B6254_RS01990	COG0750	zinc metalloprotease
B6254_RS01995	COG0442	prolyl-tRNA aminoacylation
B6254_RS02000	COG2176	DNA-directed DNA polymerase activity
B6254_RS02085	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B6254_RS02090	COG1040	competence protein
B6254_RS02095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B6254_RS02100	COG2873	o-acetylhomoserine
B6254_RS02110	COG2183	response to ionizing radiation
B6254_RS02130	COG1940	carbohydrate kinase activity
B6254_RS02135	COG2723	6-phospho-beta-galactosidase activity
B6254_RS02140	COG3711	transcriptional antiterminator
B6254_RS02160	COG1309	transcriptional regulator
B6254_RS02180	COG2217	Heavy metal translocating P-type atpase
B6254_RS02185	COG2814	Major facilitator Superfamily
B6254_RS02215	COG2217	Heavy metal translocating P-type atpase
B6254_RS02225	COG2235	arginine
B6254_RS02230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B6254_RS02255	COG3759	membrane
B6254_RS02260	COG1136	(ABC) transporter
B6254_RS02265	COG0577	efflux transmembrane transporter activity
B6254_RS02295	COG1609	Transcriptional regulator
B6254_RS02310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6254_RS02325	COG0246	Mannitol dehydrogenase
B6254_RS02330	COG1312	Catalyzes the dehydration of D-mannonate
B6254_RS02335	COG1904	glucuronate isomerase
B6254_RS02340	COG0800	Aldolase
B6254_RS02345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6254_RS02350	COG1464	Belongs to the NlpA lipoprotein family
B6254_RS02355	COG1506	peptidase
B6254_RS02355	COG4946	Tricorn protease homolog
B6254_RS02355	COG0823	Involved in the tonB-independent uptake of proteins
B6254_RS02365	COG0561	phosphatase activity
B6254_RS02380	COG0302	gtp cyclohydrolase
B6254_RS02380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B6254_RS02385	COG0302	gtp cyclohydrolase
B6254_RS02390	COG0285	dihydrofolate synthase activity
B6254_RS02400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6254_RS02405	COG1116	anion transmembrane transporter activity
B6254_RS02415	COG0318	PFAM AMP-dependent synthetase and ligase
B6254_RS02425	COG2223	nitrite transmembrane transporter activity
B6254_RS02455	COG1609	Transcriptional regulator
B6254_RS02470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6254_RS02495	COG1609	Transcriptional regulator
B6254_RS02500	COG1869	D-ribose catabolic process
B6254_RS02505	COG0738	Major facilitator superfamily
B6254_RS02630	COG4166	transmembrane transport
B6254_RS02635	COG1228	amidohydrolase
B6254_RS02655	COG0516	GMP reductase activity
B6254_RS02690	COG1126	abc transporter atp-binding protein
B6254_RS02700	COG0668	transmembrane transport
B6254_RS02720	COG0741	lytic transglycosylase activity
B6254_RS02725	COG0673	inositol 2-dehydrogenase activity
B6254_RS02730	COG0402	S-adenosylhomocysteine deaminase activity
B6254_RS02735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B6254_RS02740	COG0745	RESPONSE REGULATOR receiver
B6254_RS02745	COG5002	protein histidine kinase activity
B6254_RS02745	COG3850	Histidine kinase
B6254_RS02750	COG4975	Glucose uptake
B6254_RS02760	COG2017	converts alpha-aldose to the beta-anomer
B6254_RS02770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B6254_RS02775	COG1302	Protein conserved in bacteria
B6254_RS02790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B6254_RS02795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B6254_RS02800	COG1744	ABC transporter substrate-binding protein PnrA-like
B6254_RS02810	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B6254_RS02815	COG0626	cystathionine gamma-synthase activity
B6254_RS02820	COG0460	homoserine dehydrogenase
B6254_RS02830	COG0601	transmembrane transport
B6254_RS02835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6254_RS02840	COG0444	Belongs to the ABC transporter superfamily
B6254_RS02845	COG4608	Belongs to the ABC transporter superfamily
B6254_RS02850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B6254_RS02855	COG0049	tRNA binding
B6254_RS02860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B6254_RS02870	COG3842	ATPase activity
B6254_RS02880	COG1177	transmembrane transport
B6254_RS02890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B6254_RS02900	COG0589	response to stress
B6254_RS02910	COG1950	PFAM Membrane protein of
B6254_RS02915	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B6254_RS02920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B6254_RS02925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B6254_RS02950	COG0492	ferredoxin-NADP+ reductase activity
B6254_RS02955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6254_RS02965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6254_RS02970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6254_RS02975	COG0149	triose-phosphate isomerase activity
B6254_RS02995	COG0154	amidase activity
B6254_RS03000	COG2814	Major facilitator Superfamily
B6254_RS03010	COG0557	exoribonuclease II activity
B6254_RS03030	COG0765	amino acid transport
B6254_RS03035	COG1126	abc transporter atp-binding protein
B6254_RS03040	COG2076	Multidrug Resistance protein
B6254_RS03045	COG2076	Multidrug Resistance protein
B6254_RS03055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B6254_RS03060	COG0280	phosphate acetyltransferase
B6254_RS03065	COG0802	atpase or kinase
B6254_RS03080	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B6254_RS03095	COG4856	YbbR-like protein
B6254_RS03100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6254_RS03120	COG0540	Belongs to the ATCase OTCase family
B6254_RS03125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6254_RS03130	COG0505	Belongs to the CarA family
B6254_RS03135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B6254_RS03140	COG0167	dihydroorotate dehydrogenase activity
B6254_RS03145	COG0284	orotidine-5'-phosphate decarboxylase activity
B6254_RS03150	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B6254_RS03155	COG0438	transferase activity, transferring glycosyl groups
B6254_RS03160	COG0438	transferase activity, transferring glycosyl groups
B6254_RS03175	COG1368	sulfuric ester hydrolase activity
B6254_RS03235	COG1397	ADP-ribosylglycohydrolase
B6254_RS03250	COG3715	PTS system
B6254_RS03255	COG3716	PTS system mannose fructose sorbose family IID component
B6254_RS03265	COG0588	phosphoglycerate mutase activity
B6254_RS03315	COG0126	phosphoglycerate kinase activity
B6254_RS03320	COG0583	DNA-binding transcription factor activity
B6254_RS03330	COG0105	UTP biosynthetic process
B6254_RS03335	COG1012	belongs to the aldehyde dehydrogenase family
B6254_RS03335	COG1454	alcohol dehydrogenase
B6254_RS03345	COG0656	L-ascorbic acid biosynthetic process
B6254_RS03360	COG4974	Belongs to the 'phage' integrase family
B6254_RS03385	COG1396	sequence-specific DNA binding
B6254_RS03660	COG1113	amino acid transport
B6254_RS03665	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B6254_RS03670	COG1757	Na H antiporter
B6254_RS03675	COG0328	RNA-DNA hybrid ribonuclease activity
B6254_RS03685	COG0564	pseudouridine synthase activity
B6254_RS03695	COG0505	Belongs to the CarA family
B6254_RS03705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B6254_RS03710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B6254_RS03720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B6254_RS03725	COG1846	Transcriptional regulator
B6254_RS03730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6254_RS03735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6254_RS03740	COG2070	2-Nitropropane dioxygenase
B6254_RS03745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B6254_RS03750	COG1028	Short-chain dehydrogenase reductase Sdr
B6254_RS03755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6254_RS03770	COG0439	Biotin carboxylase
B6254_RS03775	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B6254_RS03785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B6254_RS03800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6254_RS03805	COG4115	mRNA cleavage
B6254_RS03815	COG1704	LemA family
B6254_RS03820	COG0501	Belongs to the peptidase M48B family
B6254_RS03830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6254_RS03835	COG0673	inositol 2-dehydrogenase activity
B6254_RS03840	COG0513	Belongs to the DEAD box helicase family
B6254_RS03860	COG3764	Sortase (surface protein transpeptidase)
B6254_RS03865	COG1321	iron dependent repressor
B6254_RS03880	COG0083	homoserine kinase activity
B6254_RS03885	COG1609	Transcriptional regulator
B6254_RS03895	COG0527	aspartate kinase activity
B6254_RS03900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B6254_RS03910	COG2171	N-acyltransferase activity
B6254_RS03920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6254_RS03925	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B6254_RS03930	COG0436	Aminotransferase
B6254_RS03935	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B6254_RS03940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B6254_RS03955	COG0436	Aminotransferase
B6254_RS03960	COG4684	Psort location CytoplasmicMembrane, score
B6254_RS03975	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B6254_RS03980	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B6254_RS03985	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B6254_RS03990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B6254_RS03995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6254_RS04000	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B6254_RS04005	COG0710	3-dehydroquinate dehydratase activity
B6254_RS04020	COG1122	ATPase activity
B6254_RS04025	COG4721	ABC-type cobalt transport system, permease component
B6254_RS04030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6254_RS04035	COG0667	Aldo Keto reductase
B6254_RS04055	COG1914	H( )-stimulated, divalent metal cation uptake system
B6254_RS04065	COG1695	Transcriptional regulator
B6254_RS04090	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B6254_RS04090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6254_RS04095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6254_RS04100	COG0154	amidase activity
B6254_RS04105	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6254_RS04110	COG1597	lipid kinase activity
B6254_RS04130	COG1121	(ABC) transporter
B6254_RS04140	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B6254_RS04155	COG0018	arginyl-trna synthetase
B6254_RS04175	COG1438	arginine binding
B6254_RS04180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6254_RS04185	COG3679	Belongs to the UPF0342 family
B6254_RS04195	COG4717	serine-type aminopeptidase activity
B6254_RS04215	COG0028	Belongs to the TPP enzyme family
B6254_RS04230	COG0612	Peptidase, M16
B6254_RS04235	COG0612	Peptidase, M16
B6254_RS04240	COG1426	Protein conserved in bacteria
B6254_RS04245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B6254_RS04250	COG1546	Belongs to the CinA family
B6254_RS04250	COG1058	Belongs to the CinA family
B6254_RS04255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B6254_RS04265	COG3973	AAA domain
B6254_RS04275	COG0741	lytic transglycosylase activity
B6254_RS04280	COG2814	Major facilitator Superfamily
B6254_RS04290	COG1278	Cold shock
B6254_RS04295	COG0564	pseudouridine synthase activity
B6254_RS04310	COG2309	aminopeptidase activity
B6254_RS04430	COG3883	PFAM NLP P60 protein
B6254_RS04430	COG0791	NLP P60 protein
B6254_RS04450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6254_RS04470	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B6254_RS04480	COG3475	LICD family
B6254_RS04485	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B6254_RS04490	COG1063	alcohol dehydrogenase
B6254_RS04495	COG1388	LysM domain
B6254_RS04495	COG1134	teichoic acid transport
B6254_RS04500	COG1682	transport, permease protein
B6254_RS04520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B6254_RS04555	COG4974	Belongs to the 'phage' integrase family
B6254_RS04580	COG1396	sequence-specific DNA binding
B6254_RS04630	COG0629	single-stranded DNA binding
B6254_RS04800	COG0024	Methionine aminopeptidase
B6254_RS04830	COG0562	UDP-galactopyranose mutase
B6254_RS04845	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6254_RS04855	COG0463	Glycosyl transferase, family 2
B6254_RS04865	COG1216	Glycosyl transferase, family 2
B6254_RS04895	COG1420	regulation of RNA biosynthetic process
B6254_RS04905	COG0443	Heat shock 70 kDa protein
B6254_RS04910	COG0484	heat shock protein binding
B6254_RS04925	COG1234	tRNA 3'-trailer cleavage
B6254_RS04930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B6254_RS04930	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B6254_RS04950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B6254_RS04955	COG4224	UPF0291 protein
B6254_RS04960	COG3763	UPF0154 protein
B6254_RS04975	COG0791	NLP P60 protein
B6254_RS04975	COG3883	PFAM NLP P60 protein
B6254_RS04980	COG0204	Acyl-transferase
B6254_RS04985	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B6254_RS04990	COG2827	Endonuclease containing a URI domain
B6254_RS04995	COG0052	Belongs to the universal ribosomal protein uS2 family
B6254_RS05000	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B6254_RS05010	COG0233	cytoplasmic translational termination
B6254_RS05015	COG4464	protein tyrosine phosphatase activity
B6254_RS05025	COG0489	protein tyrosine kinase activity
B6254_RS05030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B6254_RS05035	COG0438	transferase activity, transferring glycosyl groups
B6254_RS05045	COG1216	Glycosyl transferase, family 2
B6254_RS05055	COG1216	Glycosyl transferase, family 2
B6254_RS05060	COG1316	TRANSCRIPTIONal
B6254_RS05065	COG0366	Alpha amylase catalytic
B6254_RS05065	COG5263	repeat protein
B6254_RS05075	COG0004	ammonium transporteR
B6254_RS05080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6254_RS05090	COG1136	(ABC) transporter
B6254_RS05105	COG0617	tRNA 3'-terminal CCA addition
B6254_RS05110	COG0488	(ABC) transporter
B6254_RS05115	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B6254_RS05125	COG0587	DNA-directed DNA polymerase activity
B6254_RS05130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6254_RS05135	COG1490	D-aminoacyl-tRNA deacylase activity
B6254_RS05145	COG0475	glutathione-regulated potassium exporter activity
B6254_RS05155	COG2996	Protein conserved in bacteria
B6254_RS05170	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B6254_RS05175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B6254_RS05180	COG1187	pseudouridine synthase activity
B6254_RS05195	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B6254_RS05205	COG0514	ATP-dependent DNA helicase (RecQ)
B6254_RS05215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B6254_RS05220	COG0539	negative regulation of cytoplasmic translation
B6254_RS05225	COG1160	GTP binding
B6254_RS05235	COG0351	phosphomethylpyrimidine kinase
B6254_RS05240	COG4720	Psort location CytoplasmicMembrane, score
B6254_RS05245	COG2807	transmembrane transport
B6254_RS05260	COG0419	ATPase involved in DNA repair
B6254_RS05295	COG0457	Tetratricopeptide repeat
B6254_RS05300	COG0071	Belongs to the small heat shock protein (HSP20) family
B6254_RS05305	COG2384	SAM-dependent methyltransferase
B6254_RS05310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B6254_RS05340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B6254_RS05345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B6254_RS05355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6254_RS05365	COG0577	efflux transmembrane transporter activity
B6254_RS05370	COG1136	(ABC) transporter
B6254_RS05385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6254_RS05395	COG0281	malic enzyme
B6254_RS05400	COG0583	DNA-binding transcription factor activity
B6254_RS05405	COG4221	oxidoreductase activity
B6254_RS05410	COG0531	amino acid
B6254_RS05420	COG4708	membrane
B6254_RS05425	COG1028	Short-chain dehydrogenase reductase Sdr
B6254_RS05455	COG0481	GTPase activity
B6254_RS05465	COG0531	amino acid
B6254_RS05485	COG2723	6-phospho-beta-galactosidase activity
B6254_RS05495	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B6254_RS05505	COG0306	phosphate transporter
B6254_RS05515	COG1609	Transcriptional regulator
B6254_RS05525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6254_RS05525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6254_RS05525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6254_RS05530	COG1105	Belongs to the carbohydrate kinase PfkB family
B6254_RS05535	COG1349	DNA-binding transcription factor activity
B6254_RS05540	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
B6254_RS05545	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6254_RS05575	COG1397	ADP-ribosylglycohydrolase
B6254_RS05580	COG1719	4-vinyl reductase, 4VR
B6254_RS05585	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B6254_RS05595	COG1131	(ABC) transporter
B6254_RS05600	COG0537	adenosine 5'-monophosphoramidase activity
B6254_RS05610	COG0363	glucosamine-6-phosphate deaminase activity
B6254_RS05615	COG3104	oligopeptide transport
B6254_RS05620	COG0825	malonyl-CoA metabolic process
B6254_RS05625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B6254_RS05630	COG0439	Biotin carboxylase
B6254_RS05640	COG0556	nucleotide-excision repair
B6254_RS05660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B6254_RS05670	COG0116	Belongs to the methyltransferase superfamily
B6254_RS05680	COG3599	regulation of cell shape
B6254_RS05685	COG4474	Belongs to the UPF0398 family
B6254_RS05690	COG3331	DNA recombination
B6254_RS05700	COG3935	DnaD domain protein
B6254_RS05925	COG3723	Recombinational DNA repair protein, rece pathway
B6254_RS05985	COG0582	viral genome integration into host DNA
B6254_RS05990	COG0017	Asparaginyl-tRNA synthetase
B6254_RS06000	COG1199	ATP-dependent helicase activity
B6254_RS06000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6254_RS06020	COG1304	FMN binding
B6254_RS06030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6254_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
B6254_RS06040	COG0706	membrane insertase activity
B6254_RS06065	COG1388	LysM domain
B6254_RS06065	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6254_RS06075	COG5002	protein histidine kinase activity
B6254_RS06080	COG0745	RESPONSE REGULATOR receiver
B6254_RS06095	COG1484	DNA-dependent DNA replication
B6254_RS06105	COG0237	dephospho-CoA kinase activity
B6254_RS06110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B6254_RS06115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6254_RS06115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6254_RS06120	COG0670	Belongs to the BI1 family
B6254_RS06125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B6254_RS06135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6254_RS06140	COG1363	Peptidase, m42
B6254_RS06145	COG0572	uridine kinase
B6254_RS06150	COG5002	protein histidine kinase activity
B6254_RS06155	COG0745	RESPONSE REGULATOR receiver
B6254_RS06185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B6254_RS06190	COG0358	DNA primase activity
B6254_RS06225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6254_RS06250	COG0741	lytic transglycosylase activity
B6254_RS06250	COG0739	heme binding
B6254_RS06250	COG1196	nuclear chromosome segregation
B6254_RS06280	COG1192	Involved in chromosome partitioning
B6254_RS06305	COG0542	response to heat
B6254_RS06405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B6254_RS06415	COG0673	inositol 2-dehydrogenase activity
B6254_RS06425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6254_RS06450	COG0406	alpha-ribazole phosphatase activity
B6254_RS06455	COG0583	DNA-binding transcription factor activity
B6254_RS06555	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B6254_RS06560	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B6254_RS06570	COG0477	Major facilitator Superfamily
B6254_RS06575	COG3480	Lon protease (S16) C-terminal proteolytic domain
B6254_RS06580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B6254_RS06585	COG0742	ribosomal rna small subunit methyltransferase
B6254_RS06590	COG4471	UPF0298 protein
B6254_RS06595	COG0772	Belongs to the SEDS family
B6254_RS06600	COG1217	gtp-binding protein TYPA
B6254_RS06605	COG0483	inositol monophosphate 1-phosphatase activity
B6254_RS06610	COG4476	Belongs to the UPF0223 family
B6254_RS06615	COG0242	peptide deformylase activity
B6254_RS06630	COG5503	Protein of unknown function (DUF1447)
B6254_RS06650	COG1011	Hydrolase
B6254_RS06655	COG1597	lipid kinase activity
B6254_RS06660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6254_RS06665	COG1464	Belongs to the NlpA lipoprotein family
B6254_RS06670	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6254_RS06680	COG3448	diguanylate cyclase activity
B6254_RS06680	COG4175	Glycine betaine
B6254_RS06700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B6254_RS06710	COG4974	Belongs to the 'phage' integrase family
B6254_RS06715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6254_RS06720	COG0758	DNA mediated transformation
B6254_RS06725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B6254_RS06735	COG4479	Belongs to the UPF0346 family
B6254_RS06745	COG2755	lipolytic protein G-D-S-L family
B6254_RS06750	COG1307	EDD domain protein, DegV family
B6254_RS06755	COG1307	EDD domain protein, DegV family
B6254_RS06760	COG2270	Major facilitator Superfamily
B6254_RS06775	COG3142	Participates in the control of copper homeostasis
B6254_RS06780	COG1293	RNA-binding protein homologous to eukaryotic snRNP
B6254_RS06785	COG0196	riboflavin kinase activity
B6254_RS06795	COG1252	NADH dehydrogenase
B6254_RS06800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6254_RS06805	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B6254_RS06810	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B6254_RS06820	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B6254_RS06825	COG0195	Participates in both transcription termination and antitermination
B6254_RS06830	COG0779	Required for maturation of 30S ribosomal subunits
B6254_RS06845	COG1304	FMN binding
B6254_RS06865	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B6254_RS06870	COG0738	Major facilitator superfamily
B6254_RS06885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6254_RS06890	COG4684	Psort location CytoplasmicMembrane, score
B6254_RS06895	COG1621	beta-fructofuranosidase activity
B6254_RS06905	COG0384	phenazine biosynthesis protein PhzF
B6254_RS06925	COG1942	4-Oxalocrotonate Tautomerase
B6254_RS06940	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B6254_RS06965	COG1279	arginine transmembrane transporter activity
B6254_RS07020	COG0456	acetyltransferase
B6254_RS07025	COG1846	Transcriptional regulator
B6254_RS07035	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6254_RS07040	COG0656	L-ascorbic acid biosynthetic process
B6254_RS07050	COG0583	DNA-binding transcription factor activity
B6254_RS07055	COG4166	transmembrane transport
B6254_RS07085	COG0488	(ABC) transporter
B6254_RS07100	COG2814	Major facilitator Superfamily
B6254_RS07105	COG2239	Acts as a magnesium transporter
B6254_RS07110	COG0564	pseudouridine synthase activity
B6254_RS07115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B6254_RS07120	COG2357	RelA SpoT domain protein
B6254_RS07135	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B6254_RS07140	COG1518	maintenance of DNA repeat elements
B6254_RS07155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B6254_RS07160	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B6254_RS07240	COG1940	carbohydrate kinase activity
B6254_RS07250	COG1028	Short-chain dehydrogenase reductase Sdr
B6254_RS07275	COG0352	thiamine-phosphate diphosphorylase activity
B6254_RS07280	COG0351	phosphomethylpyrimidine kinase
B6254_RS07285	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B6254_RS07295	COG1464	Belongs to the NlpA lipoprotein family
B6254_RS07310	COG0436	Aminotransferase
B6254_RS07315	COG0277	FAD linked oxidase domain protein
B6254_RS07395	COG1122	ATPase activity
B6254_RS07400	COG4720	Psort location CytoplasmicMembrane, score
B6254_RS07410	COG0604	alcohol dehydrogenase
B6254_RS07410	COG3321	synthase
B6254_RS07415	COG0248	Ppx GppA phosphatase
B6254_RS07420	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B6254_RS07425	COG0277	FAD linked oxidase domain protein
B6254_RS07440	COG0028	Belongs to the TPP enzyme family
B6254_RS07475	COG3201	nicotinamide mononucleotide transporter
B6254_RS07480	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B6254_RS07505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B6254_RS07520	COG1473	amidohydrolase
B6254_RS07525	COG3527	Alpha-acetolactate decarboxylase
B6254_RS07530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B6254_RS07535	COG0187	DNA topoisomerase II activity
B6254_RS07540	COG3118	belongs to the thioredoxin family
B6254_RS07560	COG1193	negative regulation of DNA recombination
B6254_RS07580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B6254_RS07585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B6254_RS07590	COG0544	peptidyl-prolyl cis-trans isomerase activity
B6254_RS07615	COG0268	Binds directly to 16S ribosomal RNA
B6254_RS07620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B6254_RS07625	COG1466	dna polymerase III delta subunit
B6254_RS07630	COG0658	competence protein
B6254_RS07630	COG2333	competence protein COMEC
B6254_RS07640	COG3906	Belongs to the UPF0473 family
B6254_RS07660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6254_RS07665	COG1929	Belongs to the glycerate kinase type-1 family
B6254_RS07670	COG0513	Belongs to the DEAD box helicase family
B6254_RS07675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B6254_RS07680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6254_RS07685	COG1862	Preprotein translocase
B6254_RS07690	COG0343	queuine tRNA-ribosyltransferase activity
B6254_RS07725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B6254_RS07730	COG2255	four-way junction helicase activity
B6254_RS07735	COG0632	four-way junction helicase activity
B6254_RS07740	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B6254_RS07745	COG0516	GMP reductase activity
B6254_RS07745	COG0517	IMP dehydrogenase activity
B6254_RS07750	COG0516	GMP reductase activity
B6254_RS07750	COG0517	IMP dehydrogenase activity
B6254_RS07765	COG1739	Uncharacterized protein family UPF0029
B6254_RS07770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6254_RS07775	COG0322	excinuclease ABC activity
B6254_RS07785	COG1668	transmembrane transport
B6254_RS07790	COG4152	abc transporter atp-binding protein
B6254_RS07800	COG1674	ftsk spoiiie
B6254_RS07810	COG0628	permease
B6254_RS07815	COG2706	6-phosphogluconolactonase activity
B6254_RS07835	COG0751	glycine-tRNA ligase activity
B6254_RS07840	COG0752	glycyl-tRNA synthetase alpha subunit
B6254_RS07850	COG1381	Involved in DNA repair and RecF pathway recombination
B6254_RS07855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B6254_RS07860	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B6254_RS07865	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B6254_RS07870	COG1702	phosphate starvation-inducible protein PhoH
B6254_RS07875	COG1610	YqeY-like protein
B6254_RS07880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B6254_RS07885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6254_RS07895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B6254_RS07900	COG0124	histidyl-tRNA synthetase
B6254_RS07905	COG0860	N-Acetylmuramoyl-L-alanine amidase
B6254_RS07920	COG3425	synthase
B6254_RS07925	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B6254_RS07995	COG0006	proline dipeptidase activity
B6254_RS08000	COG1609	Transcriptional regulator
B6254_RS08015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B6254_RS08020	COG1164	Oligoendopeptidase f
B6254_RS08030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6254_RS08035	COG2723	6-phospho-beta-galactosidase activity
B6254_RS08040	COG1447	Phosphotransferase system cellobiose-specific component IIA
B6254_RS08045	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6254_RS08050	COG2723	6-phospho-beta-galactosidase activity
B6254_RS08055	COG4862	establishment of competence for transformation
B6254_RS08060	COG1393	Belongs to the ArsC family
B6254_RS08065	COG3853	Toxic anion resistance protein (TelA)
B6254_RS08130	COG0561	phosphatase activity
B6254_RS08135	COG1970	mechanosensitive ion channel activity
B6254_RS08140	COG1428	Deoxynucleoside kinase
B6254_RS08150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B6254_RS08155	COG1942	4-Oxalocrotonate Tautomerase
B6254_RS08160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6254_RS08170	COG0335	large ribosomal subunit rRNA binding
B6254_RS08175	COG0336	Belongs to the RNA methyltransferase TrmD family
B6254_RS08180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B6254_RS08185	COG0588	phosphoglycerate mutase activity
B6254_RS08200	COG0228	four-way junction DNA binding
B6254_RS08215	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B6254_RS08220	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B6254_RS08225	COG0552	protein localization to endoplasmic reticulum
B6254_RS08230	COG1196	nuclear chromosome segregation
B6254_RS08235	COG0571	ribonuclease III activity
B6254_RS08240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6254_RS08245	COG0416	fatty acid biosynthetic process
B6254_RS08250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B6254_RS08270	COG1461	Dihydroxyacetone kinase
B6254_RS08280	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B6254_RS08290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B6254_RS08295	COG1162	GTPase activity
B6254_RS08300	COG2815	serine threonine protein kinase
B6254_RS08300	COG0515	serine threonine protein kinase
B6254_RS08305	COG0631	protein serine/threonine phosphatase activity
B6254_RS08310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B6254_RS08310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6254_RS08315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B6254_RS08320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B6254_RS08325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B6254_RS08365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B6254_RS08370	COG2252	PERMEase
B6254_RS08375	COG0217	transcriptional regulatory protein
B6254_RS08380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B6254_RS08400	COG3599	regulation of cell shape
B6254_RS08415	COG1799	cell septum assembly
B6254_RS08425	COG0849	cell division
B6254_RS08430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B6254_RS08435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B6254_RS08440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B6254_RS08445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6254_RS08450	COG0768	penicillin binding
B6254_RS08460	COG0275	rRNA processing
B6254_RS08465	COG2001	Belongs to the MraZ family
B6254_RS08475	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B6254_RS08480	COG2264	protein methyltransferase activity
B6254_RS08495	COG0833	amino acid
B6254_RS08515	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6254_RS08530	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B6254_RS08535	COG0151	Belongs to the GarS family
B6254_RS08540	COG0138	bifunctional purine biosynthesis protein purh
B6254_RS08545	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B6254_RS08550	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B6254_RS08560	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6254_RS08565	COG0047	phosphoribosylformylglycinamidine synthase activity
B6254_RS08570	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6254_RS08575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B6254_RS08580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B6254_RS08585	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B6254_RS08590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6254_RS08590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6254_RS08595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6254_RS08600	COG1126	abc transporter atp-binding protein
B6254_RS08605	COG0765	amino acid transport
B6254_RS08615	COG3338	carbonate dehydratase activity
B6254_RS08625	COG1077	Cell shape determining protein MreB Mrl
B6254_RS08630	COG2003	Belongs to the UPF0758 family
B6254_RS08645	COG2190	(PTS) system
B6254_RS08645	COG1263	PTS System
B6254_RS08645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6254_RS08650	COG1307	EDD domain protein, DegV family
B6254_RS08655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B6254_RS08660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B6254_RS08665	COG0038	chloride channel
B6254_RS08675	COG4120	Belongs to the binding-protein-dependent transport system permease family
B6254_RS08685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6254_RS08690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6254_RS08695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B6254_RS08715	COG0741	lytic transglycosylase activity
B6254_RS08725	COG0400	carboxylic ester hydrolase activity
B6254_RS08730	COG0346	lactoylglutathione lyase activity
B6254_RS08735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B6254_RS08745	COG0494	nUDIX hydrolase
B6254_RS08750	COG1278	Cold shock
B6254_RS08765	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B6254_RS08770	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6254_RS08770	COG1388	LysM domain
B6254_RS08775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B6254_RS08780	COG4988	ABC transporter
B6254_RS08785	COG1294	oxidase, subunit
B6254_RS08790	COG1271	oxidase subunit
B6254_RS08795	COG4684	Psort location CytoplasmicMembrane, score
B6254_RS08910	COG1098	S1 RNA binding domain
B6254_RS08915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B6254_RS08920	COG0586	Pfam SNARE associated Golgi protein
B6254_RS08930	COG0194	GDP metabolic process
B6254_RS08940	COG0497	DNA recombination
B6254_RS08945	COG1438	arginine binding
B6254_RS08950	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B6254_RS08955	COG0142	geranyltranstransferase activity
B6254_RS08965	COG1570	exodeoxyribonuclease VII activity
B6254_RS08970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B6254_RS08975	COG4720	Psort location CytoplasmicMembrane, score
B6254_RS08990	COG1136	(ABC) transporter
B6254_RS08995	COG0577	efflux transmembrane transporter activity
B6254_RS09005	COG0776	regulation of translation
B6254_RS09010	COG0363	glucosamine-6-phosphate deaminase activity
B6254_RS09015	COG3764	Sortase (surface protein transpeptidase)
B6254_RS09020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B6254_RS09110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B6254_RS09115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B6254_RS09125	COG1323	Belongs to the UPF0348 family
B6254_RS09130	COG2226	methyltransferase
B6254_RS09135	COG0799	negative regulation of ribosome biogenesis
B6254_RS09140	COG1713	HD superfamily hydrolase involved in NAD metabolism
B6254_RS09145	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B6254_RS09155	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B6254_RS09160	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B6254_RS09165	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6254_RS09175	COG0531	amino acid
B6254_RS09180	COG0459	protein refolding
B6254_RS09185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B6254_RS09190	COG0488	(ABC) transporter
B6254_RS09210	COG0285	dihydrofolate synthase activity
B6254_RS09220	COG0525	valine-tRNA ligase activity
B6254_RS09250	COG1272	protein, Hemolysin III
B6254_RS09365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B6254_RS09375	COG5506	Protein of unknown function (DUF1694)
B6254_RS09385	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B6254_RS09410	COG2137	regulation of response to DNA damage stimulus
B6254_RS09415	COG0704	Plays a role in the regulation of phosphate uptake
B6254_RS09420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B6254_RS09425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B6254_RS09430	COG0581	inorganic phosphate transmembrane transporter activity
B6254_RS09435	COG0573	inorganic phosphate transmembrane transporter activity
B6254_RS09465	COG0673	inositol 2-dehydrogenase activity
B6254_RS09470	COG4166	transmembrane transport
B6254_RS09475	COG0647	UMP catabolic process
B6254_RS09480	COG4470	Protein conserved in bacteria
B6254_RS09485	COG0737	Belongs to the 5'-nucleotidase family
B6254_RS09505	COG4948	Mandelate Racemase Muconate Lactonizing
B6254_RS09510	COG0596	Alpha beta hydrolase
B6254_RS09515	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B6254_RS09520	COG1169	isochorismate synthase
B6254_RS09525	COG0778	Nitroreductase
B6254_RS09530	COG1132	(ABC) transporter
B6254_RS09565	COG1472	Belongs to the glycosyl hydrolase 3 family
B6254_RS09570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B6254_RS09575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B6254_RS09600	COG0174	glutamine synthetase
B6254_RS09605	COG0789	Transcriptional regulator
B6254_RS09610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B6254_RS09615	COG0584	glycerophosphoryl diester phosphodiesterase
B6254_RS09635	COG3942	CHAP domain
B6254_RS09645	COG1940	carbohydrate kinase activity
B6254_RS09660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B6254_RS09665	COG0768	penicillin binding
B6254_RS09675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B6254_RS09680	COG0514	ATP-dependent DNA helicase (RecQ)
B6254_RS09685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B6254_RS09690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6254_RS09690	COG0072	phenylalanine-tRNA ligase activity
B6254_RS09695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B6254_RS09700	COG1733	regulation of RNA biosynthetic process
B6254_RS09710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6254_RS09730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B6254_RS09735	COG0653	protein targeting
B6254_RS09745	COG4956	integral membrane protein (PIN domain superfamily)
B6254_RS09755	COG0756	dUTP diphosphatase activity
B6254_RS09770	COG3942	CHAP domain
B6254_RS09770	COG1388	LysM domain
B6254_RS09780	COG3527	Alpha-acetolactate decarboxylase
B6254_RS09785	COG0028	Belongs to the TPP enzyme family
B6254_RS09790	COG0039	L-malate dehydrogenase activity
B6254_RS09795	COG2514	catechol 2,3-dioxygenase activity
B6254_RS09855	COG4974	Belongs to the 'phage' integrase family
B6254_RS09875	COG1914	H( )-stimulated, divalent metal cation uptake system
B6254_RS09885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6254_RS09885	COG1263	PTS System
B6254_RS09900	COG0740	serine-type endopeptidase activity
B6254_RS09905	COG1481	regulation of sporulation
B6254_RS09910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B6254_RS09925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B6254_RS09930	COG2814	Major facilitator Superfamily
B6254_RS09940	COG0671	phosphoesterase, PA-phosphatase related
B6254_RS09950	COG0366	Alpha amylase catalytic
B6254_RS09965	COG1573	uracil-dna glycosylase
B6254_RS09975	COG0028	Belongs to the TPP enzyme family
B6254_RS10000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B6254_RS10005	COG0101	tRNA pseudouridine synthase activity
B6254_RS10015	COG1122	ATPase activity
B6254_RS10020	COG1122	ATPase activity
B6254_RS10030	COG1252	NADH dehydrogenase
B6254_RS10035	COG0803	Belongs to the bacterial solute-binding protein 9 family
B6254_RS10040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B6254_RS10045	COG1121	(ABC) transporter
B6254_RS10055	COG0222	ribosome binding
B6254_RS10060	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B6254_RS10065	COG0081	regulation of translation
B6254_RS10070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B6254_RS10075	COG0250	Participates in transcription elongation, termination and antitermination
B6254_RS10080	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B6254_RS10095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6254_RS10100	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B6254_RS10105	COG1854	S-ribosylhomocysteine lyase activity
B6254_RS10110	COG1464	Belongs to the NlpA lipoprotein family
B6254_RS10115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B6254_RS10120	COG0626	cystathionine gamma-synthase activity
B6254_RS10125	COG0215	cysteine-tRNA ligase activity
B6254_RS10130	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B6254_RS10135	COG0039	L-malate dehydrogenase activity
B6254_RS10140	COG0471	metal ion transport
B6254_RS10145	COG1053	succinate dehydrogenase
B6254_RS10155	COG0583	DNA-binding transcription factor activity
B6254_RS10180	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B6254_RS10195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B6254_RS10220	COG0203	ribosomal protein L17
B6254_RS10225	COG0202	RNA polymerase activity
B6254_RS10230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B6254_RS10235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B6254_RS10240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B6254_RS10245	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B6254_RS10260	COG0200	Binds to the 23S rRNA
B6254_RS10265	COG1841	ribosomal large subunit assembly
B6254_RS10270	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B6254_RS10275	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B6254_RS10280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B6254_RS10285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B6254_RS10290	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B6254_RS10295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B6254_RS10300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B6254_RS10310	COG0255	Belongs to the universal ribosomal protein uL29 family
B6254_RS10315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B6254_RS10320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B6254_RS10325	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B6254_RS10330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B6254_RS10335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B6254_RS10340	COG0089	rRNA binding
B6254_RS10350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B6254_RS10355	COG0051	transcription antitermination factor activity, RNA binding
B6254_RS10360	COG0142	geranyltranstransferase activity
B6254_RS10365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B6254_RS10375	COG0456	acetyltransferase
B6254_RS10380	COG1214	PFAM Peptidase M22, glycoprotease
B6254_RS10385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B6254_RS10405	COG3870	Protein conserved in bacteria
B6254_RS10410	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6254_RS10435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B6254_RS10445	COG0590	tRNA wobble adenosine to inosine editing
B6254_RS10450	COG2813	Specifically methylates the guanine in position
B6254_RS10460	COG2807	transmembrane transport
B6254_RS10470	COG3620	sequence-specific DNA binding
B6254_RS10510	COG0500	methyltransferase
B6254_RS10515	COG1309	transcriptional regulator
B6254_RS10545	COG1979	alcohol dehydrogenase
B6254_RS10565	COG0085	RNA polymerase activity
B6254_RS10570	COG0542	response to heat
B6254_RS10575	COG4463	regulation of RNA biosynthetic process
B6254_RS10600	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B6254_RS10605	COG1428	Deoxynucleoside kinase
B6254_RS10615	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B6254_RS10620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B6254_RS10625	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B6254_RS10630	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B6254_RS10635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6254_RS10640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B6254_RS10645	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6254_RS10650	COG0356	it plays a direct role in the translocation of protons across the membrane
B6254_RS10655	COG2233	PERMEase
B6254_RS10665	COG0702	epimerase
B6254_RS10670	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B6254_RS10675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6254_RS10680	COG0009	L-threonylcarbamoyladenylate synthase
B6254_RS10685	COG2890	protein-(glutamine-N5) methyltransferase activity
B6254_RS10690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B6254_RS10695	COG1435	thymidine kinase activity
B6254_RS10705	COG3442	glutamine amidotransferase
B6254_RS10710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B6254_RS10715	COG1482	cell wall glycoprotein biosynthetic process
B6254_RS10725	COG0110	maltose O-acetyltransferase activity
B6254_RS10750	COG1132	(ABC) transporter
B6254_RS10755	COG1132	(ABC) transporter
B6254_RS10770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B6254_RS10775	COG0588	phosphoglycerate mutase activity
B6254_RS10795	COG0708	Exodeoxyribonuclease III
B6254_RS10800	COG1373	ATPase (AAA superfamily
B6254_RS10810	COG1012	belongs to the aldehyde dehydrogenase family
B6254_RS10810	COG1454	alcohol dehydrogenase
B6254_RS10820	COG3590	peptidase
B6254_RS10865	COG5039	Polysaccharide pyruvyl transferase
B6254_RS10875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B6254_RS10895	COG1442	glycosyl transferase family 8
B6254_RS10895	COG1216	Glycosyl transferase, family 2
B6254_RS10900	COG0438	transferase activity, transferring glycosyl groups
B6254_RS10935	COG1216	Glycosyl transferase, family 2
B6254_RS10940	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
B6254_RS10945	COG2188	Transcriptional regulator
B6254_RS10950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B6254_RS10955	COG2814	Major facilitator Superfamily
B6254_RS10960	COG1418	mRNA catabolic process
B6254_RS10975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B6254_RS10980	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B6254_RS10985	COG1215	transferase activity, transferring glycosyl groups
B6254_RS11015	COG0765	amino acid transport
B6254_RS11040	COG0656	L-ascorbic acid biosynthetic process
B6254_RS11045	COG2160	L-arabinose isomerase activity
B6254_RS11065	COG3940	Belongs to the glycosyl hydrolase 43 family
B6254_RS11080	COG0534	Mate efflux family protein
B6254_RS11085	COG0488	(ABC) transporter
B6254_RS11090	COG1373	ATPase (AAA superfamily
B6254_RS11095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B6254_RS11100	COG1121	(ABC) transporter
B6254_RS11110	COG1846	Transcriptional regulator
B6254_RS11115	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B6254_RS11115	COG2755	lipolytic protein G-D-S-L family
B6254_RS11120	COG3091	SprT-like family
B6254_RS11165	COG4975	Glucose uptake
B6254_RS11170	COG0477	Major facilitator Superfamily
B6254_RS11175	COG3104	oligopeptide transport
B6254_RS11225	COG1686	Belongs to the peptidase S11 family
B6254_RS11235	COG0745	RESPONSE REGULATOR receiver
B6254_RS11245	COG0012	GTP binding
B6254_RS11250	COG4481	Protein conserved in bacteria
B6254_RS11255	COG1475	DNA binding
B6254_RS11260	COG1192	Involved in chromosome partitioning
B6254_RS11265	COG0357	Ribosomal RNA small subunit methyltransferase G
B6254_RS11275	COG1194	a g-specific adenine glycosylase
B6254_RS11280	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B6254_RS11320	COG5002	protein histidine kinase activity
B6254_RS11325	COG0745	RESPONSE REGULATOR receiver
B6254_RS11345	COG0318	PFAM AMP-dependent synthetase and ligase
B6254_RS11350	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B6254_RS11355	COG2050	protein possibly involved in aromatic compounds catabolism
B6254_RS11360	COG1335	isochorismatase
B6254_RS11365	COG2226	methyltransferase
B6254_RS11375	COG4443	Transcriptional Coactivator p15 (PC4)
B6254_RS11380	COG0252	asparaginase activity
B6254_RS11385	COG0531	amino acid
B6254_RS11390	COG1113	amino acid transport
B6254_RS11395	COG0531	amino acid
B6254_RS11405	COG4975	Glucose uptake
B6254_RS11410	COG0477	Major facilitator Superfamily
B6254_RS11415	COG1063	alcohol dehydrogenase
B6254_RS11420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B6254_RS11425	COG0596	Alpha beta hydrolase
B6254_RS11430	COG4166	transmembrane transport
B6254_RS11435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B6254_RS11445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B6254_RS11455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6254_RS11465	COG3223	Belongs to the PsiE family
B6254_RS11475	COG0531	amino acid
B6254_RS11480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B6254_RS11495	COG2070	2-Nitropropane dioxygenase
B6254_RS11505	COG0583	DNA-binding transcription factor activity
B6254_RS11515	COG2855	membrane
B6254_RS11535	COG2855	membrane
B6254_RS11545	COG0454	-acetyltransferase
B6254_RS11545	COG0456	acetyltransferase
B6254_RS11550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B6254_RS11575	COG1113	amino acid transport
B6254_RS11605	COG0628	permease
B6254_RS11615	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B6254_RS11615	COG0392	lysyltransferase activity
B6254_RS11625	COG1254	Belongs to the acylphosphatase family
B6254_RS11630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6254_RS11635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6254_RS11640	COG0765	amino acid transport
B6254_RS11645	COG1126	abc transporter atp-binding protein
B6254_RS11655	COG1131	(ABC) transporter
B6254_RS11665	COG0390	transport system, permease component
B6254_RS11670	COG4619	ABC transporter
B6254_RS11680	COG0656	L-ascorbic acid biosynthetic process
B6254_RS11690	COG1132	(ABC) transporter
B6254_RS11695	COG1846	Transcriptional regulator
B6254_RS11715	COG1744	ABC transporter substrate-binding protein PnrA-like
B6254_RS11720	COG0697	spore germination
B6254_RS11730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6254_RS11745	COG0789	Transcriptional regulator
B6254_RS11755	COG1131	(ABC) transporter
B6254_RS11775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B6254_RS11780	COG0505	Belongs to the CarA family
B6254_RS11785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B6254_RS11790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6254_RS11800	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B6254_RS11805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B6254_RS11810	COG0165	Argininosuccinate lyase
B6254_RS11815	COG0137	argininosuccinate synthase activity
B6254_RS11820	COG1744	ABC transporter substrate-binding protein PnrA-like
B6254_RS11830	COG0561	phosphatase activity
B6254_RS11845	COG0697	spore germination
B6254_RS11875	COG2723	6-phospho-beta-galactosidase activity
B6254_RS11880	COG0517	IMP dehydrogenase activity
B6254_RS11880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B6254_RS11920	COG1881	PFAM PEBP family protein
B6254_RS11960	COG2252	PERMEase
B6254_RS11965	COG3152	Membrane
B6254_RS11985	COG0328	RNA-DNA hybrid ribonuclease activity
B6254_RS11995	COG0561	phosphatase activity
B6254_RS12000	COG2409	Drug exporters of the RND superfamily
B6254_RS12000	COG1033	growth of symbiont in host cell
B6254_RS12005	COG0577	efflux transmembrane transporter activity
B6254_RS12010	COG1136	(ABC) transporter
B6254_RS12020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B6254_RS12025	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B6254_RS12035	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6254_RS12045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6254_RS12065	COG1113	amino acid transport
B6254_RS12070	COG0569	domain protein
B6254_RS12085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B6254_RS12095	COG1120	ATPase activity
B6254_RS12105	COG0706	membrane insertase activity
B6254_RS12110	COG0594	ribonuclease P activity
B6254_RS12115	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B6254_RS12270	COG2026	Addiction module toxin, RelE StbE family
B6254_RS12335	COG2261	transglycosylase associated protein
B6254_RS12400	COG2261	transglycosylase associated protein