locus-tag	class	description
G4V46_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G4V46_RS00010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G4V46_RS00015	COG0594	ribonuclease P activity
G4V46_RS00030	COG1120	ATPase activity
G4V46_RS00035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4V46_RS00040	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
G4V46_RS00065	COG0569	domain protein
G4V46_RS00070	COG1113	amino acid transport
G4V46_RS00115	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G4V46_RS00120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G4V46_RS00125	COG0561	phosphatase activity
G4V46_RS00135	COG0328	RNA-DNA hybrid ribonuclease activity
G4V46_RS00160	COG2252	PERMEase
G4V46_RS00165	COG0431	NADPH-dependent FMN reductase
G4V46_RS00170	COG1846	Transcriptional regulator
G4V46_RS00185	COG0149	triose-phosphate isomerase activity
G4V46_RS00225	COG0517	IMP dehydrogenase activity
G4V46_RS00225	COG1125	glycine betaine transport
G4V46_RS00230	COG1174	glycine betaine transport
G4V46_RS00240	COG1464	Belongs to the NlpA lipoprotein family
G4V46_RS00245	COG0823	Involved in the tonB-independent uptake of proteins
G4V46_RS00245	COG1506	peptidase
G4V46_RS00245	COG4946	Tricorn protease homolog
G4V46_RS00310	COG1744	ABC transporter substrate-binding protein PnrA-like
G4V46_RS00330	COG1388	LysM domain
G4V46_RS00350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4V46_RS00355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4V46_RS00365	COG0697	spore germination
G4V46_RS00385	COG1846	Transcriptional regulator
G4V46_RS00390	COG1132	(ABC) transporter
G4V46_RS00400	COG0656	L-ascorbic acid biosynthetic process
G4V46_RS00410	COG4619	ABC transporter
G4V46_RS00415	COG0390	transport system, permease component
G4V46_RS00420	COG1126	abc transporter atp-binding protein
G4V46_RS00425	COG0765	amino acid transport
G4V46_RS00430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4V46_RS00435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4V46_RS00440	COG1254	Belongs to the acylphosphatase family
G4V46_RS00455	COG2801	Transposase and inactivated derivatives
G4V46_RS00470	COG2801	Transposase and inactivated derivatives
G4V46_RS00480	COG0392	lysyltransferase activity
G4V46_RS00480	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
G4V46_RS00490	COG0628	permease
G4V46_RS00510	COG2801	Transposase and inactivated derivatives
G4V46_RS00530	COG1113	amino acid transport
G4V46_RS00555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G4V46_RS00565	COG2855	membrane
G4V46_RS00585	COG1228	amidohydrolase
G4V46_RS00590	COG0531	amino acid
G4V46_RS00600	COG4975	Glucose uptake
G4V46_RS00615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4V46_RS00625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G4V46_RS00635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G4V46_RS00640	COG1063	alcohol dehydrogenase
G4V46_RS00645	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G4V46_RS00655	COG0477	Major facilitator Superfamily
G4V46_RS00665	COG0531	amino acid
G4V46_RS00705	COG1113	amino acid transport
G4V46_RS00710	COG0531	amino acid
G4V46_RS00715	COG0252	asparaginase activity
G4V46_RS00720	COG4443	Transcriptional Coactivator p15 (PC4)
G4V46_RS00730	COG2226	methyltransferase
G4V46_RS00735	COG1335	isochorismatase
G4V46_RS00740	COG2050	protein possibly involved in aromatic compounds catabolism
G4V46_RS00745	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G4V46_RS00750	COG0318	PFAM AMP-dependent synthetase and ligase
G4V46_RS00765	COG0745	RESPONSE REGULATOR receiver
G4V46_RS00770	COG5002	protein histidine kinase activity
G4V46_RS00775	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
G4V46_RS00790	COG2207	Transcriptional regulator
G4V46_RS00800	COG1511	domain protein
G4V46_RS00815	COG1194	a g-specific adenine glycosylase
G4V46_RS00820	COG1957	nucleoside hydrolase
G4V46_RS00825	COG0357	Ribosomal RNA small subunit methyltransferase G
G4V46_RS00830	COG1192	Involved in chromosome partitioning
G4V46_RS00835	COG1475	DNA binding
G4V46_RS00840	COG4481	Protein conserved in bacteria
G4V46_RS00845	COG0012	GTP binding
G4V46_RS00855	COG0745	RESPONSE REGULATOR receiver
G4V46_RS00865	COG1686	Belongs to the peptidase S11 family
G4V46_RS00915	COG3104	oligopeptide transport
G4V46_RS00920	COG0477	Major facilitator Superfamily
G4V46_RS00925	COG3479	Phenolic acid decarboxylase
G4V46_RS00960	COG3091	SprT-like family
G4V46_RS00965	COG1979	alcohol dehydrogenase
G4V46_RS00970	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G4V46_RS00970	COG2755	lipolytic protein G-D-S-L family
G4V46_RS00975	COG1846	Transcriptional regulator
G4V46_RS00985	COG1121	(ABC) transporter
G4V46_RS00995	COG0488	(ABC) transporter
G4V46_RS01000	COG0534	Mate efflux family protein
G4V46_RS01070	COG1418	mRNA catabolic process
G4V46_RS01075	COG2814	Major facilitator Superfamily
G4V46_RS01100	COG2188	Transcriptional regulator
G4V46_RS01105	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
G4V46_RS01110	COG5039	Polysaccharide pyruvyl transferase
G4V46_RS01145	COG3590	peptidase
G4V46_RS01155	COG1454	alcohol dehydrogenase
G4V46_RS01155	COG1012	belongs to the aldehyde dehydrogenase family
G4V46_RS01170	COG0708	Exodeoxyribonuclease III
G4V46_RS01175	COG1131	(ABC) transporter
G4V46_RS01195	COG0588	phosphoglycerate mutase activity
G4V46_RS01200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G4V46_RS01210	COG1132	(ABC) transporter
G4V46_RS01215	COG1132	(ABC) transporter
G4V46_RS01230	COG2801	Transposase and inactivated derivatives
G4V46_RS01245	COG2801	Transposase and inactivated derivatives
G4V46_RS01270	COG1482	cell wall glycoprotein biosynthetic process
G4V46_RS01285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G4V46_RS01290	COG3442	glutamine amidotransferase
G4V46_RS01310	COG1435	thymidine kinase activity
G4V46_RS01320	COG2890	protein-(glutamine-N5) methyltransferase activity
G4V46_RS01325	COG0009	L-threonylcarbamoyladenylate synthase
G4V46_RS01330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G4V46_RS01335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G4V46_RS01340	COG0702	epimerase
G4V46_RS01345	COG2233	PERMEase
G4V46_RS01350	COG0356	it plays a direct role in the translocation of protons across the membrane
G4V46_RS01355	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4V46_RS01360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G4V46_RS01365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4V46_RS01370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G4V46_RS01375	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G4V46_RS01380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G4V46_RS01385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G4V46_RS01390	COG1876	peptidase activity
G4V46_RS01395	COG1428	Deoxynucleoside kinase
G4V46_RS01400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G4V46_RS01405	COG1686	Belongs to the peptidase S11 family
G4V46_RS01430	COG4463	regulation of RNA biosynthetic process
G4V46_RS01435	COG0542	response to heat
G4V46_RS01440	COG0085	RNA polymerase activity
G4V46_RS01450	COG1979	alcohol dehydrogenase
G4V46_RS01470	COG0500	methyltransferase
G4V46_RS01505	COG2807	transmembrane transport
G4V46_RS01515	COG2813	Specifically methylates the guanine in position
G4V46_RS01530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G4V46_RS01540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G4V46_RS01555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4V46_RS01560	COG3870	Protein conserved in bacteria
G4V46_RS01580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G4V46_RS01600	COG2801	Transposase and inactivated derivatives
G4V46_RS01615	COG1214	PFAM Peptidase M22, glycoprotease
G4V46_RS01630	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G4V46_RS01640	COG0051	transcription antitermination factor activity, RNA binding
G4V46_RS01645	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G4V46_RS01655	COG0089	rRNA binding
G4V46_RS01660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G4V46_RS01665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G4V46_RS01670	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G4V46_RS01675	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G4V46_RS01680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G4V46_RS01685	COG0255	Belongs to the universal ribosomal protein uL29 family
G4V46_RS01695	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G4V46_RS01700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G4V46_RS01705	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G4V46_RS01710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G4V46_RS01715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G4V46_RS01720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G4V46_RS01725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G4V46_RS01730	COG1841	ribosomal large subunit assembly
G4V46_RS01735	COG0200	Binds to the 23S rRNA
G4V46_RS01750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G4V46_RS01755	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G4V46_RS01760	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G4V46_RS01765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G4V46_RS01770	COG0202	RNA polymerase activity
G4V46_RS01775	COG0203	ribosomal protein L17
G4V46_RS01800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G4V46_RS01815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G4V46_RS01825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4V46_RS01840	COG0215	cysteine-tRNA ligase activity
G4V46_RS01850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G4V46_RS01855	COG1464	Belongs to the NlpA lipoprotein family
G4V46_RS01860	COG1854	S-ribosylhomocysteine lyase activity
G4V46_RS01865	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
G4V46_RS01870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4V46_RS01885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G4V46_RS01890	COG0250	Participates in transcription elongation, termination and antitermination
G4V46_RS01895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G4V46_RS01900	COG0081	regulation of translation
G4V46_RS01905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G4V46_RS01910	COG0222	ribosome binding
G4V46_RS01920	COG1121	(ABC) transporter
G4V46_RS01925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4V46_RS01930	COG0803	Belongs to the bacterial solute-binding protein 9 family
G4V46_RS01935	COG1252	NADH dehydrogenase
G4V46_RS01945	COG1122	ATPase activity
G4V46_RS01950	COG1122	ATPase activity
G4V46_RS01960	COG0101	tRNA pseudouridine synthase activity
G4V46_RS01965	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G4V46_RS01985	COG2814	Major facilitator Superfamily
G4V46_RS01995	COG0028	Belongs to the TPP enzyme family
G4V46_RS02000	COG1573	uracil-dna glycosylase
G4V46_RS02010	COG0366	Alpha amylase catalytic
G4V46_RS02025	COG0671	phosphoesterase, PA-phosphatase related
G4V46_RS02040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4V46_RS02055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G4V46_RS02060	COG1481	regulation of sporulation
G4V46_RS02065	COG0740	serine-type endopeptidase activity
G4V46_RS02080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4V46_RS02080	COG1263	PTS System
G4V46_RS02080	COG2190	(PTS) system
G4V46_RS02090	COG1914	H( )-stimulated, divalent metal cation uptake system
G4V46_RS02110	COG2514	catechol 2,3-dioxygenase activity
G4V46_RS02115	COG2801	Transposase and inactivated derivatives
G4V46_RS02130	COG1215	transferase activity, transferring glycosyl groups
G4V46_RS02145	COG0039	L-malate dehydrogenase activity
G4V46_RS02150	COG0028	Belongs to the TPP enzyme family
G4V46_RS02155	COG3527	Alpha-acetolactate decarboxylase
G4V46_RS02165	COG1388	LysM domain
G4V46_RS02165	COG0791	NLP P60 protein
G4V46_RS02180	COG0756	dUTP diphosphatase activity
G4V46_RS02190	COG4956	integral membrane protein (PIN domain superfamily)
G4V46_RS02200	COG0653	protein targeting
G4V46_RS02205	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G4V46_RS02215	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
G4V46_RS02245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4V46_RS02270	COG1733	regulation of RNA biosynthetic process
G4V46_RS02275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G4V46_RS02280	COG0072	phenylalanine-tRNA ligase activity
G4V46_RS02280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4V46_RS02285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G4V46_RS02290	COG0514	ATP-dependent DNA helicase (RecQ)
G4V46_RS02295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4V46_RS02310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G4V46_RS02325	COG1940	carbohydrate kinase activity
G4V46_RS02335	COG4942	peptidase
G4V46_RS02340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4V46_RS02355	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G4V46_RS02360	COG0789	Transcriptional regulator
G4V46_RS02365	COG0174	glutamine synthetase
G4V46_RS02390	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G4V46_RS02395	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G4V46_RS02430	COG1396	sequence-specific DNA binding
G4V46_RS02670	COG1523	belongs to the glycosyl hydrolase 13 family
G4V46_RS02680	COG1472	Belongs to the glycosyl hydrolase 3 family
G4V46_RS02710	COG2801	Transposase and inactivated derivatives
G4V46_RS02720	COG1132	(ABC) transporter
G4V46_RS02725	COG1169	isochorismate synthase
G4V46_RS02730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
G4V46_RS02735	COG0596	Alpha beta hydrolase
G4V46_RS02740	COG4948	Mandelate Racemase Muconate Lactonizing
G4V46_RS02745	COG0006	proline dipeptidase activity
G4V46_RS02765	COG4470	Protein conserved in bacteria
G4V46_RS02770	COG0647	UMP catabolic process
G4V46_RS02775	COG4166	transmembrane transport
G4V46_RS02780	COG0673	inositol 2-dehydrogenase activity
G4V46_RS02785	COG1957	nucleoside hydrolase
G4V46_RS02805	COG0573	inorganic phosphate transmembrane transporter activity
G4V46_RS02810	COG0581	inorganic phosphate transmembrane transporter activity
G4V46_RS02815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4V46_RS02820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4V46_RS02825	COG0704	Plays a role in the regulation of phosphate uptake
G4V46_RS02830	COG2137	regulation of response to DNA damage stimulus
G4V46_RS02845	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G4V46_RS02860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G4V46_RS02890	COG1272	protein, Hemolysin III
G4V46_RS02905	COG0525	valine-tRNA ligase activity
G4V46_RS02910	COG0285	dihydrofolate synthase activity
G4V46_RS02925	COG0488	(ABC) transporter
G4V46_RS02930	COG2814	Major facilitator Superfamily
G4V46_RS02940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G4V46_RS02945	COG0459	protein refolding
G4V46_RS02950	COG0531	amino acid
G4V46_RS02960	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4V46_RS02965	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
G4V46_RS02970	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G4V46_RS02980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G4V46_RS02985	COG1713	HD superfamily hydrolase involved in NAD metabolism
G4V46_RS02990	COG0799	negative regulation of ribosome biogenesis
G4V46_RS02995	COG2226	methyltransferase
G4V46_RS03000	COG1323	Belongs to the UPF0348 family
G4V46_RS03010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G4V46_RS03015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G4V46_RS03040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G4V46_RS03045	COG0363	glucosamine-6-phosphate deaminase activity
G4V46_RS03060	COG0577	efflux transmembrane transporter activity
G4V46_RS03065	COG1136	(ABC) transporter
G4V46_RS03080	COG4720	Psort location CytoplasmicMembrane, score
G4V46_RS03085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G4V46_RS03100	COG0142	geranyltranstransferase activity
G4V46_RS03105	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
G4V46_RS03110	COG1438	arginine binding
G4V46_RS03115	COG0497	DNA recombination
G4V46_RS03125	COG0194	GDP metabolic process
G4V46_RS03130	COG1758	RNA polymerase activity
G4V46_RS03135	COG0586	Pfam SNARE associated Golgi protein
G4V46_RS03145	COG1098	S1 RNA binding domain
G4V46_RS03255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4V46_RS03260	COG4684	Psort location CytoplasmicMembrane, score
G4V46_RS03265	COG1271	oxidase subunit
G4V46_RS03270	COG1294	oxidase, subunit
G4V46_RS03275	COG4988	ABC transporter
G4V46_RS03280	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G4V46_RS03285	COG1705	Flagellar rod assembly protein muramidase FlgJ
G4V46_RS03290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G4V46_RS03330	COG1278	Cold shock
G4V46_RS03335	COG0494	nUDIX hydrolase
G4V46_RS03345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G4V46_RS03350	COG0346	lactoylglutathione lyase activity
G4V46_RS03355	COG0400	carboxylic ester hydrolase activity
G4V46_RS03365	COG0741	lytic transglycosylase activity
G4V46_RS03385	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G4V46_RS03390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4V46_RS03405	COG4120	Belongs to the binding-protein-dependent transport system permease family
G4V46_RS03415	COG0038	chloride channel
G4V46_RS03420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G4V46_RS03425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G4V46_RS03430	COG1307	EDD domain protein, DegV family
G4V46_RS03435	COG2190	(PTS) system
G4V46_RS03435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4V46_RS03435	COG1263	PTS System
G4V46_RS03450	COG2003	Belongs to the UPF0758 family
G4V46_RS03455	COG1077	Cell shape determining protein MreB Mrl
G4V46_RS03475	COG0765	amino acid transport
G4V46_RS03480	COG1126	abc transporter atp-binding protein
G4V46_RS03490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4V46_RS03490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4V46_RS03495	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G4V46_RS03500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G4V46_RS03510	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4V46_RS03515	COG0047	phosphoribosylformylglycinamidine synthase activity
G4V46_RS03520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4V46_RS03535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G4V46_RS03540	COG0138	bifunctional purine biosynthesis protein purh
G4V46_RS03545	COG0151	Belongs to the GarS family
G4V46_RS03550	COG2759	Belongs to the formate--tetrahydrofolate ligase family
G4V46_RS03565	COG0833	amino acid
G4V46_RS03575	COG2264	protein methyltransferase activity
G4V46_RS03580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G4V46_RS03590	COG2001	Belongs to the MraZ family
G4V46_RS03595	COG0275	rRNA processing
G4V46_RS03610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4V46_RS03615	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G4V46_RS03620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G4V46_RS03625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G4V46_RS03630	COG0849	cell division
G4V46_RS03635	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G4V46_RS03640	COG1799	cell septum assembly
G4V46_RS03655	COG3599	regulation of cell shape
G4V46_RS03665	COG0406	alpha-ribazole phosphatase activity
G4V46_RS03675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G4V46_RS03680	COG0217	transcriptional regulatory protein
G4V46_RS03685	COG2252	PERMEase
G4V46_RS03690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G4V46_RS03735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G4V46_RS03760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G4V46_RS03765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G4V46_RS03770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G4V46_RS03770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4V46_RS03780	COG0515	serine threonine protein kinase
G4V46_RS03780	COG2815	serine threonine protein kinase
G4V46_RS03785	COG1162	GTPase activity
G4V46_RS03790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G4V46_RS03795	COG1564	THIamine pyrophosphokinase
G4V46_RS03800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G4V46_RS03810	COG1461	Dihydroxyacetone kinase
G4V46_RS03830	COG2211	Major facilitator Superfamily
G4V46_RS03835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G4V46_RS03840	COG0416	fatty acid biosynthetic process
G4V46_RS03845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4V46_RS03850	COG0571	ribonuclease III activity
G4V46_RS03855	COG1196	nuclear chromosome segregation
G4V46_RS03860	COG0552	protein localization to endoplasmic reticulum
G4V46_RS03865	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
G4V46_RS03870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G4V46_RS03890	COG0228	four-way junction DNA binding
G4V46_RS03900	COG0588	phosphoglycerate mutase activity
G4V46_RS03905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G4V46_RS03910	COG0336	Belongs to the RNA methyltransferase TrmD family
G4V46_RS03925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4V46_RS03930	COG1942	4-Oxalocrotonate Tautomerase
G4V46_RS03945	COG1428	Deoxynucleoside kinase
G4V46_RS03950	COG1970	mechanosensitive ion channel activity
G4V46_RS03955	COG0561	phosphatase activity
G4V46_RS03990	COG4974	Belongs to the 'phage' integrase family
G4V46_RS04070	COG3723	Recombinational DNA repair protein, rece pathway
G4V46_RS04355	COG3853	Toxic anion resistance protein (TelA)
G4V46_RS04360	COG1393	Belongs to the ArsC family
G4V46_RS04375	COG2801	Transposase and inactivated derivatives
G4V46_RS04405	COG1164	Oligoendopeptidase f
G4V46_RS04410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G4V46_RS04425	COG1609	Transcriptional regulator
G4V46_RS04430	COG0006	proline dipeptidase activity
G4V46_RS04510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G4V46_RS04515	COG3425	synthase
G4V46_RS04540	COG0124	histidyl-tRNA synthetase
G4V46_RS04545	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G4V46_RS04555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4V46_RS04560	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G4V46_RS04565	COG1610	YqeY-like protein
G4V46_RS04570	COG1702	phosphate starvation-inducible protein PhoH
G4V46_RS04575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G4V46_RS04580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G4V46_RS04585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G4V46_RS04590	COG1381	Involved in DNA repair and RecF pathway recombination
G4V46_RS04605	COG0752	glycyl-tRNA synthetase alpha subunit
G4V46_RS04610	COG0751	glycine-tRNA ligase activity
G4V46_RS04630	COG2706	6-phosphogluconolactonase activity
G4V46_RS04635	COG0628	permease
G4V46_RS04645	COG1674	ftsk spoiiie
G4V46_RS04655	COG4152	abc transporter atp-binding protein
G4V46_RS04660	COG1668	transmembrane transport
G4V46_RS04670	COG0322	excinuclease ABC activity
G4V46_RS04680	COG1739	Uncharacterized protein family UPF0029
G4V46_RS04690	COG2814	Major facilitator Superfamily
G4V46_RS04695	COG0517	IMP dehydrogenase activity
G4V46_RS04695	COG0516	GMP reductase activity
G4V46_RS04700	COG0516	GMP reductase activity
G4V46_RS04700	COG0517	IMP dehydrogenase activity
G4V46_RS04705	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G4V46_RS04710	COG0632	four-way junction helicase activity
G4V46_RS04715	COG2255	four-way junction helicase activity
G4V46_RS04720	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G4V46_RS04755	COG0343	queuine tRNA-ribosyltransferase activity
G4V46_RS04760	COG1862	Preprotein translocase
G4V46_RS04765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4V46_RS04770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G4V46_RS04775	COG0513	Belongs to the DEAD box helicase family
G4V46_RS04790	COG1929	Belongs to the glycerate kinase type-1 family
G4V46_RS04795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G4V46_RS04810	COG3906	Belongs to the UPF0473 family
G4V46_RS04815	COG3906	Belongs to the UPF0473 family
G4V46_RS04820	COG1596	polysaccharide export
G4V46_RS04820	COG1555	photosystem II stabilization
G4V46_RS04825	COG0658	competence protein
G4V46_RS04825	COG2333	competence protein COMEC
G4V46_RS04830	COG1466	dna polymerase III delta subunit
G4V46_RS04835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G4V46_RS04840	COG0268	Binds directly to 16S ribosomal RNA
G4V46_RS04875	COG0544	peptidyl-prolyl cis-trans isomerase activity
G4V46_RS04880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G4V46_RS04885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G4V46_RS04910	COG1193	negative regulation of DNA recombination
G4V46_RS04940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G4V46_RS04955	COG3118	belongs to the thioredoxin family
G4V46_RS04960	COG0110	maltose O-acetyltransferase activity
G4V46_RS04965	COG0737	Belongs to the 5'-nucleotidase family
G4V46_RS04970	COG3842	ATPase activity
G4V46_RS04975	COG1175	transmembrane transport
G4V46_RS04980	COG0395	ABC-type sugar transport system, permease component
G4V46_RS05010	COG2801	Transposase and inactivated derivatives
G4V46_RS05025	COG0308	aminopeptidase N
G4V46_RS05060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G4V46_RS05080	COG0681	Belongs to the peptidase S26 family
G4V46_RS05100	COG1621	beta-fructofuranosidase activity
G4V46_RS05105	COG1609	Transcriptional regulator
G4V46_RS05140	COG1131	(ABC) transporter
G4V46_RS05155	COG4720	Psort location CytoplasmicMembrane, score
G4V46_RS05160	COG1122	ATPase activity
G4V46_RS05175	COG2801	Transposase and inactivated derivatives
G4V46_RS05230	COG2723	6-phospho-beta-galactosidase activity
G4V46_RS05255	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
G4V46_RS05260	COG0351	phosphomethylpyrimidine kinase
G4V46_RS05265	COG0352	thiamine-phosphate diphosphorylase activity
G4V46_RS05345	COG0546	phosphoglycolate phosphatase activity
G4V46_RS05350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G4V46_RS05355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G4V46_RS05370	COG2357	RelA SpoT domain protein
G4V46_RS05375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G4V46_RS05380	COG0564	pseudouridine synthase activity
G4V46_RS05385	COG2239	Acts as a magnesium transporter
G4V46_RS05390	COG2814	Major facilitator Superfamily
G4V46_RS05395	COG1131	(ABC) transporter
G4V46_RS05420	COG1869	D-ribose catabolic process
G4V46_RS05425	COG0738	Major facilitator superfamily
G4V46_RS05465	COG2315	Protein conserved in bacteria
G4V46_RS05490	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4V46_RS05515	COG0656	L-ascorbic acid biosynthetic process
G4V46_RS05520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4V46_RS05535	COG1846	Transcriptional regulator
G4V46_RS05540	COG0456	acetyltransferase
G4V46_RS05550	COG1309	transcriptional regulator
G4V46_RS05595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G4V46_RS05605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G4V46_RS05610	COG0738	Major facilitator superfamily
G4V46_RS05615	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G4V46_RS05625	COG0277	FAD linked oxidase domain protein
G4V46_RS05645	COG2814	Major facilitator Superfamily
G4V46_RS05650	COG1304	FMN binding
G4V46_RS05660	COG0779	Required for maturation of 30S ribosomal subunits
G4V46_RS05665	COG0195	Participates in both transcription termination and antitermination
G4V46_RS05670	COG2740	Nucleic-acid-binding protein implicated in transcription termination
G4V46_RS05680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G4V46_RS05685	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G4V46_RS05690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G4V46_RS05710	COG0196	riboflavin kinase activity
G4V46_RS05715	COG1293	RNA-binding protein homologous to eukaryotic snRNP
G4V46_RS05720	COG3142	Participates in the control of copper homeostasis
G4V46_RS05735	COG2270	Major facilitator Superfamily
G4V46_RS05740	COG1307	EDD domain protein, DegV family
G4V46_RS05745	COG1307	EDD domain protein, DegV family
G4V46_RS05750	COG2755	lipolytic protein G-D-S-L family
G4V46_RS05760	COG4479	Belongs to the UPF0346 family
G4V46_RS05770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G4V46_RS05780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4V46_RS05785	COG4974	Belongs to the 'phage' integrase family
G4V46_RS05795	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G4V46_RS05800	COG0187	DNA topoisomerase II activity
G4V46_RS05820	COG3448	diguanylate cyclase activity
G4V46_RS05820	COG4175	Glycine betaine
G4V46_RS05830	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4V46_RS05835	COG1464	Belongs to the NlpA lipoprotein family
G4V46_RS05840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G4V46_RS05845	COG1597	lipid kinase activity
G4V46_RS05850	COG1011	Hydrolase
G4V46_RS05890	COG0242	peptide deformylase activity
G4V46_RS05895	COG4476	Belongs to the UPF0223 family
G4V46_RS05900	COG0483	inositol monophosphate 1-phosphatase activity
G4V46_RS05910	COG0772	Belongs to the SEDS family
G4V46_RS05915	COG4471	UPF0298 protein
G4V46_RS05920	COG0742	ribosomal rna small subunit methyltransferase
G4V46_RS05925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G4V46_RS05930	COG3480	Lon protease (S16) C-terminal proteolytic domain
G4V46_RS05935	COG0105	UTP biosynthetic process
G4V46_RS05940	COG0477	Major facilitator Superfamily
G4V46_RS05945	COG0358	DNA primase activity
G4V46_RS05950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4V46_RS05975	COG0745	RESPONSE REGULATOR receiver
G4V46_RS05980	COG5002	protein histidine kinase activity
G4V46_RS05985	COG0572	uridine kinase
G4V46_RS05990	COG1363	Peptidase, m42
G4V46_RS05995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4V46_RS06005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G4V46_RS06015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4V46_RS06015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4V46_RS06020	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4V46_RS06035	COG1484	DNA-dependent DNA replication
G4V46_RS06050	COG0745	RESPONSE REGULATOR receiver
G4V46_RS06055	COG5002	protein histidine kinase activity
G4V46_RS06075	COG1942	4-Oxalocrotonate Tautomerase
G4V46_RS06090	COG0706	membrane insertase activity
G4V46_RS06095	COG1028	Short-chain dehydrogenase reductase Sdr
G4V46_RS06100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4V46_RS06110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4V46_RS06125	COG0577	efflux transmembrane transporter activity
G4V46_RS06130	COG1136	(ABC) transporter
G4V46_RS06135	COG2076	Multidrug Resistance protein
G4V46_RS06140	COG2076	Multidrug Resistance protein
G4V46_RS06150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4V46_RS06165	COG0281	malic enzyme
G4V46_RS06170	COG0583	DNA-binding transcription factor activity
G4V46_RS06175	COG4221	oxidoreductase activity
G4V46_RS06180	COG0531	amino acid
G4V46_RS06190	COG4708	membrane
G4V46_RS06210	COG0481	GTPase activity
G4V46_RS06220	COG0531	amino acid
G4V46_RS06250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4V46_RS06260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G4V46_RS06275	COG1914	H( )-stimulated, divalent metal cation uptake system
G4V46_RS06305	COG2801	Transposase and inactivated derivatives
G4V46_RS06410	COG1719	4-vinyl reductase, 4VR
G4V46_RS06415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G4V46_RS06425	COG1131	(ABC) transporter
G4V46_RS06430	COG0537	adenosine 5'-monophosphoramidase activity
G4V46_RS06440	COG0363	glucosamine-6-phosphate deaminase activity
G4V46_RS06445	COG3104	oligopeptide transport
G4V46_RS06465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4V46_RS06480	COG0825	malonyl-CoA metabolic process
G4V46_RS06485	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G4V46_RS06490	COG0439	Biotin carboxylase
G4V46_RS06500	COG0556	nucleotide-excision repair
G4V46_RS06515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4V46_RS06525	COG0116	Belongs to the methyltransferase superfamily
G4V46_RS06535	COG3599	regulation of cell shape
G4V46_RS06540	COG4474	Belongs to the UPF0398 family
G4V46_RS06545	COG3331	DNA recombination
G4V46_RS06550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4V46_RS06555	COG1132	(ABC) transporter
G4V46_RS06560	COG1132	(ABC) transporter
G4V46_RS06565	COG0747	negative chemotaxis
G4V46_RS06570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4V46_RS06575	COG0601	transmembrane transport
G4V46_RS06580	COG4608	Belongs to the ABC transporter superfamily
G4V46_RS06585	COG0444	Belongs to the ABC transporter superfamily
G4V46_RS06590	COG3935	DnaD domain protein
G4V46_RS06690	COG2801	Transposase and inactivated derivatives
G4V46_RS06835	COG1396	sequence-specific DNA binding
G4V46_RS06860	COG0582	viral genome integration into host DNA
G4V46_RS06865	COG0017	Asparaginyl-tRNA synthetase
G4V46_RS06870	COG5353	protein conserved in bacteria
G4V46_RS06875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G4V46_RS06875	COG1199	ATP-dependent helicase activity
G4V46_RS06895	COG1304	FMN binding
G4V46_RS06910	COG3620	sequence-specific DNA binding
G4V46_RS06925	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
G4V46_RS06930	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
G4V46_RS06935	COG2211	Major facilitator Superfamily
G4V46_RS06935	COG2190	(PTS) system
G4V46_RS06950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G4V46_RS06955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G4V46_RS06970	COG2801	Transposase and inactivated derivatives
G4V46_RS06985	COG2357	RelA SpoT domain protein
G4V46_RS07005	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G4V46_RS07015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G4V46_RS07025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G4V46_RS07030	COG2384	SAM-dependent methyltransferase
G4V46_RS07035	COG0071	Belongs to the small heat shock protein (HSP20) family
G4V46_RS07070	COG0457	Tetratricopeptide repeat
G4V46_RS07110	COG0419	ATPase involved in DNA repair
G4V46_RS07115	COG0420	3'-5' exonuclease activity
G4V46_RS07125	COG2807	transmembrane transport
G4V46_RS07130	COG4720	Psort location CytoplasmicMembrane, score
G4V46_RS07145	COG1160	GTP binding
G4V46_RS07150	COG0539	negative regulation of cytoplasmic translation
G4V46_RS07155	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G4V46_RS07165	COG0514	ATP-dependent DNA helicase (RecQ)
G4V46_RS07175	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
G4V46_RS07190	COG1187	pseudouridine synthase activity
G4V46_RS07195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G4V46_RS07200	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G4V46_RS07215	COG2996	Protein conserved in bacteria
G4V46_RS07230	COG0475	glutathione-regulated potassium exporter activity
G4V46_RS07240	COG1490	D-aminoacyl-tRNA deacylase activity
G4V46_RS07245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4V46_RS07250	COG0587	DNA-directed DNA polymerase activity
G4V46_RS07265	COG0488	(ABC) transporter
G4V46_RS07270	COG0617	tRNA 3'-terminal CCA addition
G4V46_RS07290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4V46_RS07295	COG0004	ammonium transporteR
G4V46_RS07310	COG4464	protein tyrosine phosphatase activity
G4V46_RS07315	COG1316	TRANSCRIPTIONal
G4V46_RS07325	COG0233	cytoplasmic translational termination
G4V46_RS07335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G4V46_RS07355	COG2827	Endonuclease containing a URI domain
G4V46_RS07360	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G4V46_RS07365	COG0204	Acyl-transferase
G4V46_RS07375	COG2801	Transposase and inactivated derivatives
G4V46_RS07385	COG3763	UPF0154 protein
G4V46_RS07390	COG4224	UPF0291 protein
G4V46_RS07395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G4V46_RS07410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G4V46_RS07410	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
G4V46_RS07415	COG1234	tRNA 3'-trailer cleavage
G4V46_RS07435	COG0484	heat shock protein binding
G4V46_RS07440	COG0443	Heat shock 70 kDa protein
G4V46_RS07450	COG1420	regulation of RNA biosynthetic process
G4V46_RS07460	COG1682	transport, permease protein
G4V46_RS07465	COG1388	LysM domain
G4V46_RS07465	COG1134	teichoic acid transport
G4V46_RS07475	COG1216	Glycosyl transferase, family 2
G4V46_RS07480	COG0562	UDP-galactopyranose mutase
G4V46_RS07490	COG0463	Glycosyl transferase, family 2
G4V46_RS07500	COG0024	Methionine aminopeptidase
G4V46_RS07525	COG2801	Transposase and inactivated derivatives
G4V46_RS07555	COG1705	Flagellar rod assembly protein muramidase FlgJ
G4V46_RS07555	COG1388	LysM domain
G4V46_RS07575	COG2235	arginine
G4V46_RS07595	COG2309	aminopeptidase activity
G4V46_RS07610	COG0564	pseudouridine synthase activity
G4V46_RS07615	COG1278	Cold shock
G4V46_RS07630	COG0741	lytic transglycosylase activity
G4V46_RS07640	COG3973	AAA domain
G4V46_RS07660	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G4V46_RS07665	COG1058	Belongs to the CinA family
G4V46_RS07665	COG1546	Belongs to the CinA family
G4V46_RS07670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4V46_RS07675	COG1426	Protein conserved in bacteria
G4V46_RS07680	COG0612	Peptidase, M16
G4V46_RS07685	COG0612	Peptidase, M16
G4V46_RS07705	COG1070	Carbohydrate kinase
G4V46_RS07735	COG0420	3'-5' exonuclease activity
G4V46_RS07740	COG3679	Belongs to the UPF0342 family
G4V46_RS07745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4V46_RS07750	COG1438	arginine binding
G4V46_RS07755	COG0306	phosphate transporter
G4V46_RS07760	COG0519	Catalyzes the synthesis of GMP from XMP
G4V46_RS07765	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G4V46_RS07770	COG0018	arginyl-trna synthetase
G4V46_RS07785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G4V46_RS07795	COG1121	(ABC) transporter
G4V46_RS07815	COG1597	lipid kinase activity
G4V46_RS07820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G4V46_RS07825	COG0154	amidase activity
G4V46_RS07830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G4V46_RS07835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G4V46_RS07835	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
G4V46_RS07865	COG1914	H( )-stimulated, divalent metal cation uptake system
G4V46_RS07870	COG0456	acetyltransferase
G4V46_RS07890	COG0667	Aldo Keto reductase
G4V46_RS07895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G4V46_RS07900	COG0167	dihydroorotate dehydrogenase activity
G4V46_RS07910	COG1122	ATPase activity
G4V46_RS07920	COG2115	Belongs to the xylose isomerase family
G4V46_RS07925	COG0710	3-dehydroquinate dehydratase activity
G4V46_RS07930	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G4V46_RS07935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G4V46_RS07940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G4V46_RS07945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G4V46_RS07950	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G4V46_RS07955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G4V46_RS07975	COG0438	transferase activity, transferring glycosyl groups
G4V46_RS07990	COG4684	Psort location CytoplasmicMembrane, score
G4V46_RS07995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4V46_RS08015	COG1609	Transcriptional regulator
G4V46_RS08020	COG1136	(ABC) transporter
G4V46_RS08020	COG0577	efflux transmembrane transporter activity
G4V46_RS08025	COG1136	(ABC) transporter
G4V46_RS08040	COG1131	(ABC) transporter
G4V46_RS08045	COG2188	Transcriptional regulator
G4V46_RS08055	COG0436	Aminotransferase
G4V46_RS08065	COG0596	Alpha beta hydrolase
G4V46_RS08070	COG4166	transmembrane transport
G4V46_RS08080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G4V46_RS08085	COG0436	Aminotransferase
G4V46_RS08090	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G4V46_RS08095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4V46_RS08100	COG1473	amidohydrolase
G4V46_RS08105	COG2171	N-acyltransferase activity
G4V46_RS08115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4V46_RS08120	COG0527	aspartate kinase activity
G4V46_RS08130	COG1609	Transcriptional regulator
G4V46_RS08135	COG0083	homoserine kinase activity
G4V46_RS08150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4V46_RS08150	COG1321	iron dependent repressor
G4V46_RS08160	COG2801	Transposase and inactivated derivatives
G4V46_RS08165	COG3764	Sortase (surface protein transpeptidase)
G4V46_RS08170	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G4V46_RS08175	COG0513	Belongs to the DEAD box helicase family
G4V46_RS08180	COG0673	inositol 2-dehydrogenase activity
G4V46_RS08185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4V46_RS08190	COG0501	Belongs to the peptidase M48B family
G4V46_RS08195	COG1704	LemA family
G4V46_RS08200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4V46_RS08205	COG4115	mRNA cleavage
G4V46_RS08210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4V46_RS08225	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G4V46_RS08230	COG0439	Biotin carboxylase
G4V46_RS08245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4V46_RS08250	COG1028	Short-chain dehydrogenase reductase Sdr
G4V46_RS08255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G4V46_RS08260	COG2070	2-Nitropropane dioxygenase
G4V46_RS08265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4V46_RS08270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4V46_RS08275	COG1846	Transcriptional regulator
G4V46_RS08280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G4V46_RS08290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G4V46_RS08295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4V46_RS08305	COG0505	Belongs to the CarA family
G4V46_RS08315	COG0564	pseudouridine synthase activity
G4V46_RS08325	COG0328	RNA-DNA hybrid ribonuclease activity
G4V46_RS08365	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
G4V46_RS08370	COG1113	amino acid transport
G4V46_RS08385	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
G4V46_RS08405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G4V46_RS08410	COG1132	(ABC) transporter
G4V46_RS08415	COG1132	(ABC) transporter
G4V46_RS08420	COG0583	DNA-binding transcription factor activity
G4V46_RS08425	COG1811	Na channel or pump
G4V46_RS08430	COG0126	phosphoglycerate kinase activity
G4V46_RS08490	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
G4V46_RS08500	COG1696	Membrane protein involved in D-alanine export
G4V46_RS08515	COG0588	phosphoglycerate mutase activity
G4V46_RS08525	COG3716	PTS system mannose fructose sorbose family IID component
G4V46_RS08530	COG3715	PTS system
G4V46_RS08540	COG1027	Aspartate ammonia-lyase
G4V46_RS08550	COG1397	ADP-ribosylglycohydrolase
G4V46_RS08610	COG1368	sulfuric ester hydrolase activity
G4V46_RS08625	COG0438	transferase activity, transferring glycosyl groups
G4V46_RS08630	COG0438	transferase activity, transferring glycosyl groups
G4V46_RS08635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G4V46_RS08640	COG0284	orotidine-5'-phosphate decarboxylase activity
G4V46_RS08645	COG0167	dihydroorotate dehydrogenase activity
G4V46_RS08650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G4V46_RS08655	COG0505	Belongs to the CarA family
G4V46_RS08665	COG0540	Belongs to the ATCase OTCase family
G4V46_RS08690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4V46_RS08695	COG4856	YbbR-like protein
G4V46_RS08710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G4V46_RS08720	COG0456	acetyltransferase
G4V46_RS08725	COG0802	atpase or kinase
G4V46_RS08730	COG0280	phosphate acetyltransferase
G4V46_RS08745	COG2076	Multidrug Resistance protein
G4V46_RS08750	COG2076	Multidrug Resistance protein
G4V46_RS08755	COG1126	abc transporter atp-binding protein
G4V46_RS08760	COG0765	amino acid transport
G4V46_RS08770	COG0557	exoribonuclease II activity
G4V46_RS08780	COG2814	Major facilitator Superfamily
G4V46_RS08790	COG2801	Transposase and inactivated derivatives
G4V46_RS08815	COG0149	triose-phosphate isomerase activity
G4V46_RS08820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4V46_RS08825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4V46_RS08835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4V46_RS08840	COG0492	ferredoxin-NADP+ reductase activity
G4V46_RS08855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4V46_RS08860	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G4V46_RS08865	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G4V46_RS08880	COG0589	response to stress
G4V46_RS08890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4V46_RS08900	COG1177	transmembrane transport
G4V46_RS08910	COG3842	ATPase activity
G4V46_RS08920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G4V46_RS08925	COG0049	tRNA binding
G4V46_RS08930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G4V46_RS08945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G4V46_RS08950	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G4V46_RS08955	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G4V46_RS08965	COG1302	Protein conserved in bacteria
G4V46_RS08970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G4V46_RS08980	COG2017	converts alpha-aldose to the beta-anomer
G4V46_RS08990	COG4975	Glucose uptake
G4V46_RS08995	COG3850	Histidine kinase
G4V46_RS08995	COG5002	protein histidine kinase activity
G4V46_RS09000	COG0745	RESPONSE REGULATOR receiver
G4V46_RS09005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G4V46_RS09010	COG0402	S-adenosylhomocysteine deaminase activity
G4V46_RS09025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4V46_RS09040	COG0668	transmembrane transport
G4V46_RS09045	COG0516	GMP reductase activity
G4V46_RS09050	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4V46_RS09130	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G4V46_RS09135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4V46_RS09135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4V46_RS09145	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4V46_RS09145	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4V46_RS09165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G4V46_RS09190	COG2801	Transposase and inactivated derivatives
G4V46_RS09210	COG2801	Transposase and inactivated derivatives
G4V46_RS09225	COG1266	CAAX protease self-immunity
G4V46_RS09240	COG4166	transmembrane transport
G4V46_RS09260	COG0561	phosphatase activity
G4V46_RS09295	COG0577	efflux transmembrane transporter activity
G4V46_RS09300	COG1136	(ABC) transporter
G4V46_RS09310	COG0436	Aminotransferase
G4V46_RS09315	COG3759	membrane
G4V46_RS09320	COG2723	6-phospho-beta-galactosidase activity
G4V46_RS09325	COG1263	PTS System
G4V46_RS09325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G4V46_RS09340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4V46_RS09355	COG1609	Transcriptional regulator
G4V46_RS09385	COG2814	Major facilitator Superfamily
G4V46_RS09390	COG2217	Heavy metal translocating P-type atpase
G4V46_RS09400	COG0431	NADPH-dependent FMN reductase
G4V46_RS09415	COG2409	Drug exporters of the RND superfamily
G4V46_RS09415	COG1033	growth of symbiont in host cell
G4V46_RS09430	COG2183	response to ionizing radiation
G4V46_RS09440	COG2873	o-acetylhomoserine
G4V46_RS09445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G4V46_RS09455	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
G4V46_RS09500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4V46_RS09520	COG1131	(ABC) transporter
G4V46_RS09570	COG2176	DNA-directed DNA polymerase activity
G4V46_RS09575	COG0442	prolyl-tRNA aminoacylation
G4V46_RS09580	COG0750	zinc metalloprotease
G4V46_RS09585	COG4589	Belongs to the CDS family
G4V46_RS09590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G4V46_RS09595	COG0561	phosphatase activity
G4V46_RS09645	COG0656	L-ascorbic acid biosynthetic process
G4V46_RS09655	COG2814	Major facilitator Superfamily
G4V46_RS09675	COG1307	EDD domain protein, DegV family
G4V46_RS09705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G4V46_RS09715	COG2252	PERMEase
G4V46_RS09720	COG0352	thiamine-phosphate diphosphorylase activity
G4V46_RS09730	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
G4V46_RS09755	COG2801	Transposase and inactivated derivatives
G4V46_RS09765	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G4V46_RS09775	COG2188	Transcriptional regulator
G4V46_RS09785	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4V46_RS09790	COG1136	(ABC) transporter
G4V46_RS09790	COG0577	efflux transmembrane transporter activity
G4V46_RS09800	COG0561	phosphatase activity
G4V46_RS09805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4V46_RS09810	COG0561	phosphatase activity
G4V46_RS09825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4V46_RS09830	COG0772	Belongs to the SEDS family
G4V46_RS09840	COG1077	Cell shape determining protein MreB Mrl
G4V46_RS09845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G4V46_RS09870	COG1744	ABC transporter substrate-binding protein PnrA-like
G4V46_RS09875	COG1744	ABC transporter substrate-binding protein PnrA-like
G4V46_RS09880	COG1744	ABC transporter substrate-binding protein PnrA-like
G4V46_RS09885	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4V46_RS09895	COG0640	Transcriptional regulator
G4V46_RS09900	COG0628	permease
G4V46_RS09905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G4V46_RS09920	COG0588	phosphoglycerate mutase activity
G4V46_RS09925	COG0492	ferredoxin-NADP+ reductase activity
G4V46_RS09945	COG1744	ABC transporter substrate-binding protein PnrA-like
G4V46_RS09955	COG2832	Protein of unknown function (DUF454)
G4V46_RS09990	COG2814	Major facilitator Superfamily
G4V46_RS09995	COG0305	Participates in initiation and elongation during chromosome replication
G4V46_RS10000	COG0359	binds to the 23S rRNA
G4V46_RS10010	COG4608	Belongs to the ABC transporter superfamily
G4V46_RS10015	COG0444	Belongs to the ABC transporter superfamily
G4V46_RS10020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4V46_RS10025	COG0601	transmembrane transport
G4V46_RS10030	COG4166	transmembrane transport
G4V46_RS10035	COG1957	nucleoside hydrolase
G4V46_RS10045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G4V46_RS10065	COG2801	Transposase and inactivated derivatives
G4V46_RS10095	COG1609	Transcriptional regulator
G4V46_RS10105	COG2814	Major facilitator Superfamily
G4V46_RS10115	COG0765	amino acid transport
G4V46_RS10120	COG0765	amino acid transport
G4V46_RS10125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4V46_RS10130	COG1126	abc transporter atp-binding protein
G4V46_RS10145	COG0194	GDP metabolic process
G4V46_RS10150	COG1268	BioY protein
G4V46_RS10180	COG2211	Major facilitator Superfamily
G4V46_RS10185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G4V46_RS10190	COG0673	inositol 2-dehydrogenase activity
G4V46_RS10205	COG3973	AAA domain
G4V46_RS10215	COG2337	Toxic component of a toxin-antitoxin (TA) module
G4V46_RS10220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4V46_RS10230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G4V46_RS10235	COG0504	CTP synthase activity
G4V46_RS10255	COG3343	RNA polymerase activity
G4V46_RS10260	COG0561	phosphatase activity
G4V46_RS10265	COG1078	dGTPase activity
G4V46_RS10275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4V46_RS10280	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G4V46_RS10295	COG5002	protein histidine kinase activity
G4V46_RS10300	COG0745	RESPONSE REGULATOR receiver
G4V46_RS10330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4V46_RS10335	COG0629	single-stranded DNA binding
G4V46_RS10340	COG0360	Binds together with S18 to 16S ribosomal RNA
G4V46_RS10350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G4V46_RS10360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G4V46_RS10365	COG1051	belongs to the nudix hydrolase family
G4V46_RS10375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G4V46_RS10380	COG2814	Major facilitator Superfamily
G4V46_RS10385	COG1064	alcohol dehydrogenase
G4V46_RS10390	COG1074	ATP-dependent DNA helicase activity
G4V46_RS10395	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
G4V46_RS10400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4V46_RS10405	COG0531	amino acid
G4V46_RS10410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G4V46_RS10420	COG1902	pentaerythritol trinitrate reductase activity
G4V46_RS10425	COG0626	cystathionine gamma-synthase activity
G4V46_RS10440	COG2244	polysaccharide biosynthetic process
G4V46_RS10450	COG0438	transferase activity, transferring glycosyl groups
G4V46_RS10455	COG0495	leucyl-tRNA aminoacylation
G4V46_RS10460	COG0671	phosphoesterase, PA-phosphatase related
G4V46_RS10470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4V46_RS10490	COG1744	ABC transporter substrate-binding protein PnrA-like
G4V46_RS10535	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G4V46_RS10565	COG2801	Transposase and inactivated derivatives
G4V46_RS10575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G4V46_RS10585	COG0024	Methionine aminopeptidase
G4V46_RS10595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G4V46_RS10600	COG0737	Belongs to the 5'-nucleotidase family
G4V46_RS10605	COG3639	organic phosphonate transmembrane transporter activity
G4V46_RS10615	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G4V46_RS10635	COG0604	alcohol dehydrogenase
G4V46_RS10640	COG1435	thymidine kinase activity
G4V46_RS10645	COG1316	TRANSCRIPTIONal
G4V46_RS10655	COG2205	protein histidine kinase activity
G4V46_RS10660	COG0745	RESPONSE REGULATOR receiver
G4V46_RS10680	COG1914	H( )-stimulated, divalent metal cation uptake system
G4V46_RS10745	COG0438	transferase activity, transferring glycosyl groups
G4V46_RS10750	COG2084	Dehydrogenase
G4V46_RS10765	COG4989	oxidoreductase activity
G4V46_RS10770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G4V46_RS10775	COG2233	PERMEase
G4V46_RS10790	COG1956	GAF domain-containing protein
G4V46_RS10800	COG1216	Glycosyl transferase, family 2
G4V46_RS10815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G4V46_RS10840	COG0531	amino acid
G4V46_RS10845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4V46_RS10850	COG2235	arginine
G4V46_RS10855	COG2910	NAD(P)H-binding
G4V46_RS10875	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G4V46_RS10880	COG1737	Transcriptional regulator
G4V46_RS10890	COG0656	L-ascorbic acid biosynthetic process
G4V46_RS10895	COG2261	transglycosylase associated protein
G4V46_RS10960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4V46_RS10965	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G4V46_RS10990	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G4V46_RS10995	COG2244	polysaccharide biosynthetic process
G4V46_RS11000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G4V46_RS11005	COG0193	aminoacyl-tRNA hydrolase activity
G4V46_RS11015	COG0366	Alpha amylase catalytic
G4V46_RS11015	COG3103	Sh3 type 3 domain protein
G4V46_RS11020	COG0058	SHG alpha-glucan phosphorylase activity
G4V46_RS11030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G4V46_RS11040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G4V46_RS11045	COG1511	domain protein
G4V46_RS11050	COG1309	transcriptional regulator
G4V46_RS11070	COG0477	Major facilitator Superfamily
G4V46_RS11085	COG2115	Belongs to the xylose isomerase family
G4V46_RS11090	COG1846	Transcriptional regulator
G4V46_RS11090	COG1940	carbohydrate kinase activity
G4V46_RS11095	COG2211	Major facilitator Superfamily
G4V46_RS11100	COG3507	Belongs to the glycosyl hydrolase 43 family
G4V46_RS11125	COG1968	undecaprenyl-diphosphatase activity
G4V46_RS11140	COG1695	Transcriptional regulator
G4V46_RS11145	COG1983	PspC domain protein
G4V46_RS11150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G4V46_RS11155	COG1316	TRANSCRIPTIONal
G4V46_RS11165	COG2131	deaminase
G4V46_RS11170	COG4466	Protein conserved in bacteria
G4V46_RS11175	COG1253	flavin adenine dinucleotide binding
G4V46_RS11180	COG1253	flavin adenine dinucleotide binding
G4V46_RS11185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G4V46_RS11190	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
G4V46_RS11195	COG0084	hydrolase, TatD family'
G4V46_RS11205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4V46_RS11205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4V46_RS11235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G4V46_RS11255	COG1368	sulfuric ester hydrolase activity
G4V46_RS11275	COG0187	DNA topoisomerase II activity
G4V46_RS11280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4V46_RS11285	COG2501	S4 domain
G4V46_RS11290	COG0592	DNA-directed DNA polymerase activity
G4V46_RS11435	COG1396	sequence-specific DNA binding
G4V46_RS11460	COG2801	Transposase and inactivated derivatives
G4V46_RS11465	COG1573	uracil-dna glycosylase
G4V46_RS11510	COG2217	Heavy metal translocating P-type atpase
G4V46_RS11515	COG2217	Heavy metal translocating P-type atpase
G4V46_RS11520	COG3682	Transcriptional regulator
G4V46_RS11525	COG1573	uracil-dna glycosylase
G4V46_RS11560	COG0783	Belongs to the Dps family
G4V46_RS11565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein