locus-tag	class	description
C6P08_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6P08_RS00015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C6P08_RS00020	COG0594	ribonuclease P activity
C6P08_RS00025	COG0706	membrane insertase activity
C6P08_RS00035	COG1120	ATPase activity
C6P08_RS00040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6P08_RS00060	COG0569	domain protein
C6P08_RS00065	COG1113	amino acid transport
C6P08_RS00105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C6P08_RS00110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C6P08_RS00115	COG0561	phosphatase activity
C6P08_RS00125	COG0328	RNA-DNA hybrid ribonuclease activity
C6P08_RS00150	COG2252	PERMEase
C6P08_RS00155	COG0431	NADPH-dependent FMN reductase
C6P08_RS00160	COG1846	Transcriptional regulator
C6P08_RS00175	COG0149	triose-phosphate isomerase activity
C6P08_RS00195	COG1881	PFAM PEBP family protein
C6P08_RS00210	COG0517	IMP dehydrogenase activity
C6P08_RS00210	COG1125	glycine betaine transport
C6P08_RS00215	COG1174	glycine betaine transport
C6P08_RS00225	COG1464	Belongs to the NlpA lipoprotein family
C6P08_RS00230	COG4946	Tricorn protease homolog
C6P08_RS00230	COG1506	peptidase
C6P08_RS00230	COG0823	Involved in the tonB-independent uptake of proteins
C6P08_RS00255	COG1744	ABC transporter substrate-binding protein PnrA-like
C6P08_RS00260	COG0137	argininosuccinate synthase activity
C6P08_RS00265	COG0165	Argininosuccinate lyase
C6P08_RS00270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C6P08_RS00275	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C6P08_RS00280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C6P08_RS00285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6P08_RS00295	COG0505	Belongs to the CarA family
C6P08_RS00320	COG1388	LysM domain
C6P08_RS00335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6P08_RS00340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6P08_RS00350	COG0697	spore germination
C6P08_RS00370	COG1846	Transcriptional regulator
C6P08_RS00375	COG1132	(ABC) transporter
C6P08_RS00385	COG0656	L-ascorbic acid biosynthetic process
C6P08_RS00395	COG4619	ABC transporter
C6P08_RS00400	COG0390	transport system, permease component
C6P08_RS00405	COG1126	abc transporter atp-binding protein
C6P08_RS00410	COG0765	amino acid transport
C6P08_RS00415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6P08_RS00420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6P08_RS00425	COG1254	Belongs to the acylphosphatase family
C6P08_RS00435	COG0392	lysyltransferase activity
C6P08_RS00435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C6P08_RS00445	COG0628	permease
C6P08_RS00465	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6P08_RS00465	COG2918	glutathione biosynthetic process
C6P08_RS00475	COG1113	amino acid transport
C6P08_RS00500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6P08_RS00510	COG2855	membrane
C6P08_RS00530	COG1228	amidohydrolase
C6P08_RS00535	COG0531	amino acid
C6P08_RS00545	COG4975	Glucose uptake
C6P08_RS00560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6P08_RS00570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C6P08_RS00580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C6P08_RS00585	COG1063	alcohol dehydrogenase
C6P08_RS00590	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C6P08_RS00595	COG0477	Major facilitator Superfamily
C6P08_RS00600	COG4975	Glucose uptake
C6P08_RS00605	COG0531	amino acid
C6P08_RS00635	COG1113	amino acid transport
C6P08_RS00640	COG0531	amino acid
C6P08_RS00645	COG0252	asparaginase activity
C6P08_RS00650	COG4443	Transcriptional Coactivator p15 (PC4)
C6P08_RS00660	COG2226	methyltransferase
C6P08_RS00665	COG1335	isochorismatase
C6P08_RS00670	COG2050	protein possibly involved in aromatic compounds catabolism
C6P08_RS00675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C6P08_RS00680	COG0318	PFAM AMP-dependent synthetase and ligase
C6P08_RS00700	COG0745	RESPONSE REGULATOR receiver
C6P08_RS00705	COG5002	protein histidine kinase activity
C6P08_RS00710	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C6P08_RS00725	COG2207	Transcriptional regulator
C6P08_RS00745	COG1194	a g-specific adenine glycosylase
C6P08_RS00750	COG1957	nucleoside hydrolase
C6P08_RS00755	COG0357	Ribosomal RNA small subunit methyltransferase G
C6P08_RS00760	COG1192	Involved in chromosome partitioning
C6P08_RS00765	COG1475	DNA binding
C6P08_RS00770	COG4481	Protein conserved in bacteria
C6P08_RS00775	COG0012	GTP binding
C6P08_RS00785	COG0745	RESPONSE REGULATOR receiver
C6P08_RS00795	COG1686	Belongs to the peptidase S11 family
C6P08_RS00850	COG3104	oligopeptide transport
C6P08_RS00855	COG0477	Major facilitator Superfamily
C6P08_RS00890	COG3091	SprT-like family
C6P08_RS00895	COG1979	alcohol dehydrogenase
C6P08_RS00900	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C6P08_RS00900	COG2755	lipolytic protein G-D-S-L family
C6P08_RS00905	COG1846	Transcriptional regulator
C6P08_RS00915	COG1121	(ABC) transporter
C6P08_RS00925	COG0488	(ABC) transporter
C6P08_RS00930	COG0534	Mate efflux family protein
C6P08_RS00965	COG0765	amino acid transport
C6P08_RS01000	COG1418	mRNA catabolic process
C6P08_RS01005	COG2814	Major facilitator Superfamily
C6P08_RS01010	COG2188	Transcriptional regulator
C6P08_RS01015	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C6P08_RS01030	COG5039	Polysaccharide pyruvyl transferase
C6P08_RS01070	COG3590	peptidase
C6P08_RS01080	COG2190	(PTS) system
C6P08_RS01080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6P08_RS01080	COG1263	PTS System
C6P08_RS01085	COG1263	PTS System
C6P08_RS01085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6P08_RS01085	COG2190	(PTS) system
C6P08_RS01090	COG0366	Alpha amylase catalytic
C6P08_RS01095	COG1454	alcohol dehydrogenase
C6P08_RS01095	COG1012	belongs to the aldehyde dehydrogenase family
C6P08_RS01105	COG0708	Exodeoxyribonuclease III
C6P08_RS01110	COG1131	(ABC) transporter
C6P08_RS01130	COG0588	phosphoglycerate mutase activity
C6P08_RS01135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C6P08_RS01145	COG1132	(ABC) transporter
C6P08_RS01150	COG1132	(ABC) transporter
C6P08_RS01180	COG1482	cell wall glycoprotein biosynthetic process
C6P08_RS01190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C6P08_RS01195	COG3442	glutamine amidotransferase
C6P08_RS01215	COG1435	thymidine kinase activity
C6P08_RS01225	COG2890	protein-(glutamine-N5) methyltransferase activity
C6P08_RS01230	COG0009	L-threonylcarbamoyladenylate synthase
C6P08_RS01235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6P08_RS01240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C6P08_RS01245	COG0702	epimerase
C6P08_RS01250	COG2233	PERMEase
C6P08_RS01255	COG0356	it plays a direct role in the translocation of protons across the membrane
C6P08_RS01260	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6P08_RS01265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C6P08_RS01270	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6P08_RS01275	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C6P08_RS01280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C6P08_RS01285	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C6P08_RS01290	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C6P08_RS01295	COG1876	peptidase activity
C6P08_RS01300	COG1428	Deoxynucleoside kinase
C6P08_RS01305	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C6P08_RS01315	COG1686	Belongs to the peptidase S11 family
C6P08_RS01340	COG4463	regulation of RNA biosynthetic process
C6P08_RS01345	COG0542	response to heat
C6P08_RS01350	COG0085	RNA polymerase activity
C6P08_RS01360	COG1979	alcohol dehydrogenase
C6P08_RS01370	COG0500	methyltransferase
C6P08_RS01390	COG1373	ATPase (AAA superfamily
C6P08_RS01410	COG2807	transmembrane transport
C6P08_RS01420	COG2813	Specifically methylates the guanine in position
C6P08_RS01435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C6P08_RS01445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C6P08_RS01460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6P08_RS01465	COG3870	Protein conserved in bacteria
C6P08_RS01485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C6P08_RS01490	COG1214	PFAM Peptidase M22, glycoprotease
C6P08_RS01505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C6P08_RS01515	COG0051	transcription antitermination factor activity, RNA binding
C6P08_RS01520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C6P08_RS01530	COG0089	rRNA binding
C6P08_RS01535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C6P08_RS01540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C6P08_RS01545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C6P08_RS01550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C6P08_RS01555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C6P08_RS01560	COG0255	Belongs to the universal ribosomal protein uL29 family
C6P08_RS01570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C6P08_RS01575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C6P08_RS01580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C6P08_RS01585	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C6P08_RS01590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C6P08_RS01595	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C6P08_RS01600	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C6P08_RS01605	COG1841	ribosomal large subunit assembly
C6P08_RS01610	COG0200	Binds to the 23S rRNA
C6P08_RS01625	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C6P08_RS01630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C6P08_RS01635	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C6P08_RS01640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C6P08_RS01645	COG0202	RNA polymerase activity
C6P08_RS01650	COG0203	ribosomal protein L17
C6P08_RS01680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C6P08_RS01695	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C6P08_RS01705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6P08_RS01720	COG0215	cysteine-tRNA ligase activity
C6P08_RS01730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C6P08_RS01735	COG1464	Belongs to the NlpA lipoprotein family
C6P08_RS01740	COG1854	S-ribosylhomocysteine lyase activity
C6P08_RS01745	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C6P08_RS01750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6P08_RS01765	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6P08_RS01770	COG0250	Participates in transcription elongation, termination and antitermination
C6P08_RS01775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C6P08_RS01780	COG0081	regulation of translation
C6P08_RS01785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C6P08_RS01790	COG0222	ribosome binding
C6P08_RS01800	COG1121	(ABC) transporter
C6P08_RS01805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6P08_RS01810	COG0803	Belongs to the bacterial solute-binding protein 9 family
C6P08_RS01815	COG1252	NADH dehydrogenase
C6P08_RS01825	COG1122	ATPase activity
C6P08_RS01830	COG1122	ATPase activity
C6P08_RS01840	COG0101	tRNA pseudouridine synthase activity
C6P08_RS01845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C6P08_RS01860	COG5263	repeat protein
C6P08_RS01860	COG0366	Alpha amylase catalytic
C6P08_RS01865	COG2814	Major facilitator Superfamily
C6P08_RS01875	COG0028	Belongs to the TPP enzyme family
C6P08_RS01880	COG1573	uracil-dna glycosylase
C6P08_RS01890	COG0366	Alpha amylase catalytic
C6P08_RS01900	COG0671	phosphoesterase, PA-phosphatase related
C6P08_RS01910	COG2814	Major facilitator Superfamily
C6P08_RS01915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6P08_RS01925	COG2801	Transposase and inactivated derivatives
C6P08_RS01940	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C6P08_RS01945	COG1481	regulation of sporulation
C6P08_RS01950	COG0740	serine-type endopeptidase activity
C6P08_RS01965	COG1263	PTS System
C6P08_RS01965	COG2190	(PTS) system
C6P08_RS01965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6P08_RS01975	COG1914	H( )-stimulated, divalent metal cation uptake system
C6P08_RS01995	COG2514	catechol 2,3-dioxygenase activity
C6P08_RS02005	COG1215	transferase activity, transferring glycosyl groups
C6P08_RS02020	COG0039	L-malate dehydrogenase activity
C6P08_RS02025	COG0028	Belongs to the TPP enzyme family
C6P08_RS02030	COG3527	Alpha-acetolactate decarboxylase
C6P08_RS02040	COG1388	LysM domain
C6P08_RS02040	COG0791	NLP P60 protein
C6P08_RS02055	COG0756	dUTP diphosphatase activity
C6P08_RS02065	COG4956	integral membrane protein (PIN domain superfamily)
C6P08_RS02080	COG0653	protein targeting
C6P08_RS02085	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C6P08_RS02095	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
C6P08_RS02115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6P08_RS02135	COG1733	regulation of RNA biosynthetic process
C6P08_RS02140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C6P08_RS02145	COG0072	phenylalanine-tRNA ligase activity
C6P08_RS02145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6P08_RS02150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C6P08_RS02155	COG0514	ATP-dependent DNA helicase (RecQ)
C6P08_RS02160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6P08_RS02170	COG0768	penicillin binding
C6P08_RS02175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C6P08_RS02180	COG0705	Rhomboid family
C6P08_RS02180	COG0457	Tetratricopeptide repeat
C6P08_RS02190	COG1940	carbohydrate kinase activity
C6P08_RS02200	COG4942	peptidase
C6P08_RS02205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6P08_RS02220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C6P08_RS02225	COG0789	Transcriptional regulator
C6P08_RS02230	COG0174	glutamine synthetase
C6P08_RS02255	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C6P08_RS02260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C6P08_RS02355	COG0629	single-stranded DNA binding
C6P08_RS02520	COG1472	Belongs to the glycosyl hydrolase 3 family
C6P08_RS02535	COG1132	(ABC) transporter
C6P08_RS02540	COG1169	isochorismate synthase
C6P08_RS02545	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C6P08_RS02550	COG0596	Alpha beta hydrolase
C6P08_RS02555	COG4948	Mandelate Racemase Muconate Lactonizing
C6P08_RS02560	COG0006	proline dipeptidase activity
C6P08_RS02575	COG0737	Belongs to the 5'-nucleotidase family
C6P08_RS02580	COG4470	Protein conserved in bacteria
C6P08_RS02585	COG0647	UMP catabolic process
C6P08_RS02590	COG4166	transmembrane transport
C6P08_RS02595	COG0673	inositol 2-dehydrogenase activity
C6P08_RS02600	COG1957	nucleoside hydrolase
C6P08_RS02605	COG2188	Transcriptional regulator
C6P08_RS02620	COG0573	inorganic phosphate transmembrane transporter activity
C6P08_RS02625	COG0581	inorganic phosphate transmembrane transporter activity
C6P08_RS02630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6P08_RS02635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6P08_RS02640	COG0704	Plays a role in the regulation of phosphate uptake
C6P08_RS02645	COG2137	regulation of response to DNA damage stimulus
C6P08_RS02660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C6P08_RS02675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C6P08_RS02685	COG0589	response to stress
C6P08_RS02705	COG1272	protein, Hemolysin III
C6P08_RS02720	COG0525	valine-tRNA ligase activity
C6P08_RS02725	COG0285	dihydrofolate synthase activity
C6P08_RS02740	COG0488	(ABC) transporter
C6P08_RS02745	COG2814	Major facilitator Superfamily
C6P08_RS02760	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C6P08_RS02765	COG0459	protein refolding
C6P08_RS02770	COG0531	amino acid
C6P08_RS02780	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6P08_RS02785	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C6P08_RS02790	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C6P08_RS02800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C6P08_RS02805	COG1713	HD superfamily hydrolase involved in NAD metabolism
C6P08_RS02810	COG0799	negative regulation of ribosome biogenesis
C6P08_RS02815	COG2226	methyltransferase
C6P08_RS02820	COG1323	Belongs to the UPF0348 family
C6P08_RS02830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C6P08_RS02835	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C6P08_RS02845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6P08_RS02860	COG0318	PFAM AMP-dependent synthetase and ligase
C6P08_RS02885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C6P08_RS02890	COG0363	glucosamine-6-phosphate deaminase activity
C6P08_RS02905	COG0577	efflux transmembrane transporter activity
C6P08_RS02910	COG1136	(ABC) transporter
C6P08_RS02925	COG4720	Psort location CytoplasmicMembrane, score
C6P08_RS02930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C6P08_RS02945	COG0142	geranyltranstransferase activity
C6P08_RS02950	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C6P08_RS02955	COG1438	arginine binding
C6P08_RS02960	COG0497	DNA recombination
C6P08_RS02970	COG0194	GDP metabolic process
C6P08_RS02975	COG1758	RNA polymerase activity
C6P08_RS02985	COG2801	Transposase and inactivated derivatives
C6P08_RS02990	COG0586	Pfam SNARE associated Golgi protein
C6P08_RS02995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C6P08_RS03000	COG1098	S1 RNA binding domain
C6P08_RS03110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6P08_RS03115	COG4684	Psort location CytoplasmicMembrane, score
C6P08_RS03120	COG1271	oxidase subunit
C6P08_RS03125	COG1294	oxidase, subunit
C6P08_RS03130	COG4988	ABC transporter
C6P08_RS03135	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C6P08_RS03145	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C6P08_RS03175	COG1278	Cold shock
C6P08_RS03180	COG0494	nUDIX hydrolase
C6P08_RS03190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C6P08_RS03195	COG0346	lactoylglutathione lyase activity
C6P08_RS03210	COG0741	lytic transglycosylase activity
C6P08_RS03230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C6P08_RS03235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6P08_RS03250	COG4120	Belongs to the binding-protein-dependent transport system permease family
C6P08_RS03260	COG0038	chloride channel
C6P08_RS03265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6P08_RS03270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6P08_RS03275	COG1307	EDD domain protein, DegV family
C6P08_RS03280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6P08_RS03280	COG1263	PTS System
C6P08_RS03280	COG2190	(PTS) system
C6P08_RS03295	COG2003	Belongs to the UPF0758 family
C6P08_RS03300	COG1077	Cell shape determining protein MreB Mrl
C6P08_RS03320	COG0765	amino acid transport
C6P08_RS03325	COG1126	abc transporter atp-binding protein
C6P08_RS03330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6P08_RS03340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C6P08_RS03345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C6P08_RS03355	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6P08_RS03360	COG0047	phosphoribosylformylglycinamidine synthase activity
C6P08_RS03365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6P08_RS03380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C6P08_RS03385	COG0138	bifunctional purine biosynthesis protein purh
C6P08_RS03390	COG0151	Belongs to the GarS family
C6P08_RS03395	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C6P08_RS03410	COG0833	amino acid
C6P08_RS03420	COG2264	protein methyltransferase activity
C6P08_RS03425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C6P08_RS03440	COG2001	Belongs to the MraZ family
C6P08_RS03445	COG0275	rRNA processing
C6P08_RS03455	COG0768	penicillin binding
C6P08_RS03460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6P08_RS03465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C6P08_RS03470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C6P08_RS03475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C6P08_RS03480	COG0849	cell division
C6P08_RS03485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C6P08_RS03490	COG1799	cell septum assembly
C6P08_RS03505	COG3599	regulation of cell shape
C6P08_RS03515	COG0406	alpha-ribazole phosphatase activity
C6P08_RS03525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6P08_RS03530	COG0217	transcriptional regulatory protein
C6P08_RS03535	COG2252	PERMEase
C6P08_RS03540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C6P08_RS03580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C6P08_RS03630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C6P08_RS03635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6P08_RS03640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C6P08_RS03640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C6P08_RS03650	COG2815	serine threonine protein kinase
C6P08_RS03650	COG0515	serine threonine protein kinase
C6P08_RS03655	COG1162	GTPase activity
C6P08_RS03660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C6P08_RS03665	COG1564	THIamine pyrophosphokinase
C6P08_RS03670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C6P08_RS03680	COG1461	Dihydroxyacetone kinase
C6P08_RS03690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C6P08_RS03695	COG0416	fatty acid biosynthetic process
C6P08_RS03700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6P08_RS03705	COG0571	ribonuclease III activity
C6P08_RS03710	COG1196	nuclear chromosome segregation
C6P08_RS03715	COG0552	protein localization to endoplasmic reticulum
C6P08_RS03720	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C6P08_RS03725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C6P08_RS03730	COG2801	Transposase and inactivated derivatives
C6P08_RS03750	COG0228	four-way junction DNA binding
C6P08_RS03765	COG0588	phosphoglycerate mutase activity
C6P08_RS03770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C6P08_RS03775	COG0336	Belongs to the RNA methyltransferase TrmD family
C6P08_RS03790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C6P08_RS03795	COG1942	4-Oxalocrotonate Tautomerase
C6P08_RS03810	COG1428	Deoxynucleoside kinase
C6P08_RS03815	COG1970	mechanosensitive ion channel activity
C6P08_RS03820	COG0561	phosphatase activity
C6P08_RS03855	COG4974	Belongs to the 'phage' integrase family
C6P08_RS04050	COG1388	LysM domain
C6P08_RS04050	COG0791	NLP P60 protein
C6P08_RS04175	COG3853	Toxic anion resistance protein (TelA)
C6P08_RS04180	COG1393	Belongs to the ArsC family
C6P08_RS04185	COG4862	establishment of competence for transformation
C6P08_RS04190	COG2723	6-phospho-beta-galactosidase activity
C6P08_RS04195	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C6P08_RS04200	COG1447	Phosphotransferase system cellobiose-specific component IIA
C6P08_RS04205	COG2723	6-phospho-beta-galactosidase activity
C6P08_RS04210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C6P08_RS04215	COG4469	Competence protein
C6P08_RS04220	COG1164	Oligoendopeptidase f
C6P08_RS04225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C6P08_RS04240	COG1609	Transcriptional regulator
C6P08_RS04245	COG0006	proline dipeptidase activity
C6P08_RS04320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C6P08_RS04325	COG3425	synthase
C6P08_RS04350	COG0124	histidyl-tRNA synthetase
C6P08_RS04355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C6P08_RS04360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C6P08_RS04365	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C6P08_RS04370	COG1610	YqeY-like protein
C6P08_RS04375	COG1702	phosphate starvation-inducible protein PhoH
C6P08_RS04380	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C6P08_RS04385	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C6P08_RS04390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C6P08_RS04395	COG1381	Involved in DNA repair and RecF pathway recombination
C6P08_RS04415	COG0752	glycyl-tRNA synthetase alpha subunit
C6P08_RS04420	COG0751	glycine-tRNA ligase activity
C6P08_RS04435	COG2706	6-phosphogluconolactonase activity
C6P08_RS04440	COG0628	permease
C6P08_RS04450	COG1674	ftsk spoiiie
C6P08_RS04460	COG4152	abc transporter atp-binding protein
C6P08_RS04465	COG1668	transmembrane transport
C6P08_RS04480	COG0322	excinuclease ABC activity
C6P08_RS04490	COG1739	Uncharacterized protein family UPF0029
C6P08_RS04505	COG0517	IMP dehydrogenase activity
C6P08_RS04505	COG0516	GMP reductase activity
C6P08_RS04510	COG0516	GMP reductase activity
C6P08_RS04510	COG0517	IMP dehydrogenase activity
C6P08_RS04515	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C6P08_RS04520	COG0632	four-way junction helicase activity
C6P08_RS04525	COG2255	four-way junction helicase activity
C6P08_RS04530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C6P08_RS04570	COG0343	queuine tRNA-ribosyltransferase activity
C6P08_RS04575	COG1862	Preprotein translocase
C6P08_RS04580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6P08_RS04585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C6P08_RS04590	COG0513	Belongs to the DEAD box helicase family
C6P08_RS04595	COG2207	Transcriptional regulator
C6P08_RS04595	COG1917	Cupin 2, conserved barrel domain protein
C6P08_RS04600	COG2814	Major facilitator Superfamily
C6P08_RS04615	COG1929	Belongs to the glycerate kinase type-1 family
C6P08_RS04620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C6P08_RS04635	COG3906	Belongs to the UPF0473 family
C6P08_RS04640	COG3906	Belongs to the UPF0473 family
C6P08_RS04645	COG1555	photosystem II stabilization
C6P08_RS04645	COG1596	polysaccharide export
C6P08_RS04650	COG0658	competence protein
C6P08_RS04650	COG2333	competence protein COMEC
C6P08_RS04655	COG1466	dna polymerase III delta subunit
C6P08_RS04660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C6P08_RS04665	COG0268	Binds directly to 16S ribosomal RNA
C6P08_RS04705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C6P08_RS04710	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C6P08_RS04730	COG1193	negative regulation of DNA recombination
C6P08_RS04745	COG1215	transferase activity, transferring glycosyl groups
C6P08_RS04755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C6P08_RS04765	COG3118	belongs to the thioredoxin family
C6P08_RS04770	COG0110	maltose O-acetyltransferase activity
C6P08_RS04775	COG0737	Belongs to the 5'-nucleotidase family
C6P08_RS04780	COG3842	ATPase activity
C6P08_RS04785	COG1175	transmembrane transport
C6P08_RS04790	COG0395	ABC-type sugar transport system, permease component
C6P08_RS04805	COG0308	aminopeptidase N
C6P08_RS04835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6P08_RS04870	COG1621	beta-fructofuranosidase activity
C6P08_RS04875	COG1609	Transcriptional regulator
C6P08_RS04910	COG1063	alcohol dehydrogenase
C6P08_RS04920	COG4720	Psort location CytoplasmicMembrane, score
C6P08_RS04925	COG1122	ATPase activity
C6P08_RS04935	COG4166	transmembrane transport
C6P08_RS04940	COG1228	amidohydrolase
C6P08_RS04945	COG2801	Transposase and inactivated derivatives
C6P08_RS04955	COG0617	tRNA 3'-terminal CCA addition
C6P08_RS04955	COG1353	crispr-associated protein
C6P08_RS04960	COG1002	Type II restriction enzyme, methylase subunits
C6P08_RS05005	COG2723	6-phospho-beta-galactosidase activity
C6P08_RS05040	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C6P08_RS05045	COG0351	phosphomethylpyrimidine kinase
C6P08_RS05050	COG0352	thiamine-phosphate diphosphorylase activity
C6P08_RS05125	COG0546	phosphoglycolate phosphatase activity
C6P08_RS05130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C6P08_RS05135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C6P08_RS05150	COG2357	RelA SpoT domain protein
C6P08_RS05155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C6P08_RS05160	COG0564	pseudouridine synthase activity
C6P08_RS05165	COG2239	Acts as a magnesium transporter
C6P08_RS05170	COG2814	Major facilitator Superfamily
C6P08_RS05195	COG2315	Protein conserved in bacteria
C6P08_RS05200	COG0488	(ABC) transporter
C6P08_RS05210	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6P08_RS05230	COG0656	L-ascorbic acid biosynthetic process
C6P08_RS05235	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6P08_RS05250	COG1846	Transcriptional regulator
C6P08_RS05305	COG0277	FAD linked oxidase domain protein
C6P08_RS05310	COG0436	Aminotransferase
C6P08_RS05350	COG0596	Alpha beta hydrolase
C6P08_RS05355	COG1942	4-Oxalocrotonate Tautomerase
C6P08_RS05370	COG1279	arginine transmembrane transporter activity
C6P08_RS05375	COG0384	phenazine biosynthesis protein PhzF
C6P08_RS05390	COG1063	alcohol dehydrogenase
C6P08_RS05420	COG1609	Transcriptional regulator
C6P08_RS05460	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
C6P08_RS05465	COG1349	DNA-binding transcription factor activity
C6P08_RS05470	COG1105	Belongs to the carbohydrate kinase PfkB family
C6P08_RS05475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6P08_RS05475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6P08_RS05475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6P08_RS05480	COG2801	Transposase and inactivated derivatives
C6P08_RS05490	COG2223	nitrite transmembrane transporter activity
C6P08_RS05500	COG0697	spore germination
C6P08_RS05510	COG4684	Psort location CytoplasmicMembrane, score
C6P08_RS05530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6P08_RS05540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C6P08_RS05545	COG0738	Major facilitator superfamily
C6P08_RS05550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C6P08_RS05555	COG0277	FAD linked oxidase domain protein
C6P08_RS05575	COG2814	Major facilitator Superfamily
C6P08_RS05590	COG0779	Required for maturation of 30S ribosomal subunits
C6P08_RS05595	COG0195	Participates in both transcription termination and antitermination
C6P08_RS05600	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C6P08_RS05610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C6P08_RS05615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C6P08_RS05620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C6P08_RS05625	COG1252	NADH dehydrogenase
C6P08_RS05635	COG0196	riboflavin kinase activity
C6P08_RS05640	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C6P08_RS05645	COG3142	Participates in the control of copper homeostasis
C6P08_RS05660	COG2270	Major facilitator Superfamily
C6P08_RS05665	COG1307	EDD domain protein, DegV family
C6P08_RS05670	COG1307	EDD domain protein, DegV family
C6P08_RS05675	COG2755	lipolytic protein G-D-S-L family
C6P08_RS05685	COG4479	Belongs to the UPF0346 family
C6P08_RS05695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C6P08_RS05700	COG0758	DNA mediated transformation
C6P08_RS05705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6P08_RS05710	COG4974	Belongs to the 'phage' integrase family
C6P08_RS05720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C6P08_RS05725	COG0187	DNA topoisomerase II activity
C6P08_RS05745	COG3448	diguanylate cyclase activity
C6P08_RS05745	COG4175	Glycine betaine
C6P08_RS05755	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6P08_RS05760	COG1464	Belongs to the NlpA lipoprotein family
C6P08_RS05770	COG2801	Transposase and inactivated derivatives
C6P08_RS05780	COG1597	lipid kinase activity
C6P08_RS05785	COG1011	Hydrolase
C6P08_RS05800	COG5503	Protein of unknown function (DUF1447)
C6P08_RS05815	COG0242	peptide deformylase activity
C6P08_RS05820	COG4476	Belongs to the UPF0223 family
C6P08_RS05825	COG0483	inositol monophosphate 1-phosphatase activity
C6P08_RS05830	COG1217	gtp-binding protein TYPA
C6P08_RS05835	COG0772	Belongs to the SEDS family
C6P08_RS05840	COG4471	UPF0298 protein
C6P08_RS05845	COG0742	ribosomal rna small subunit methyltransferase
C6P08_RS05850	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C6P08_RS05855	COG3480	Lon protease (S16) C-terminal proteolytic domain
C6P08_RS05860	COG2801	Transposase and inactivated derivatives
C6P08_RS05870	COG0105	UTP biosynthetic process
C6P08_RS05875	COG0477	Major facilitator Superfamily
C6P08_RS05880	COG0358	DNA primase activity
C6P08_RS05885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6P08_RS05910	COG0745	RESPONSE REGULATOR receiver
C6P08_RS05915	COG5002	protein histidine kinase activity
C6P08_RS05920	COG0572	uridine kinase
C6P08_RS05925	COG1363	Peptidase, m42
C6P08_RS05930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6P08_RS05940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6P08_RS05950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6P08_RS05950	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6P08_RS05955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6P08_RS05960	COG0237	dephospho-CoA kinase activity
C6P08_RS05970	COG1484	DNA-dependent DNA replication
C6P08_RS05985	COG0745	RESPONSE REGULATOR receiver
C6P08_RS05990	COG5002	protein histidine kinase activity
C6P08_RS06010	COG1942	4-Oxalocrotonate Tautomerase
C6P08_RS06025	COG0706	membrane insertase activity
C6P08_RS06030	COG1028	Short-chain dehydrogenase reductase Sdr
C6P08_RS06035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C6P08_RS06045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6P08_RS06065	COG0577	efflux transmembrane transporter activity
C6P08_RS06070	COG1136	(ABC) transporter
C6P08_RS06075	COG2076	Multidrug Resistance protein
C6P08_RS06080	COG2076	Multidrug Resistance protein
C6P08_RS06090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6P08_RS06105	COG0281	malic enzyme
C6P08_RS06110	COG0583	DNA-binding transcription factor activity
C6P08_RS06115	COG4221	oxidoreductase activity
C6P08_RS06120	COG0531	amino acid
C6P08_RS06130	COG4708	membrane
C6P08_RS06150	COG0481	GTPase activity
C6P08_RS06160	COG0531	amino acid
C6P08_RS06180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6P08_RS06195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C6P08_RS06200	COG1914	H( )-stimulated, divalent metal cation uptake system
C6P08_RS06270	COG1719	4-vinyl reductase, 4VR
C6P08_RS06275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C6P08_RS06285	COG1131	(ABC) transporter
C6P08_RS06290	COG0537	adenosine 5'-monophosphoramidase activity
C6P08_RS06300	COG0363	glucosamine-6-phosphate deaminase activity
C6P08_RS06305	COG3104	oligopeptide transport
C6P08_RS06315	COG1304	FMN binding
C6P08_RS06340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6P08_RS06345	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6P08_RS06355	COG0285	dihydrofolate synthase activity
C6P08_RS06360	COG0302	gtp cyclohydrolase
C6P08_RS06365	COG0302	gtp cyclohydrolase
C6P08_RS06365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C6P08_RS06375	COG0363	glucosamine-6-phosphate deaminase activity
C6P08_RS06380	COG2723	6-phospho-beta-galactosidase activity
C6P08_RS06390	COG2272	Belongs to the type-B carboxylesterase lipase family
C6P08_RS06395	COG0825	malonyl-CoA metabolic process
C6P08_RS06400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C6P08_RS06405	COG0439	Biotin carboxylase
C6P08_RS06415	COG0556	nucleotide-excision repair
C6P08_RS06430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6P08_RS06440	COG0116	Belongs to the methyltransferase superfamily
C6P08_RS06450	COG3599	regulation of cell shape
C6P08_RS06455	COG4474	Belongs to the UPF0398 family
C6P08_RS06460	COG3331	DNA recombination
C6P08_RS06465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6P08_RS06475	COG1132	(ABC) transporter
C6P08_RS06480	COG1132	(ABC) transporter
C6P08_RS06485	COG0747	negative chemotaxis
C6P08_RS06490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6P08_RS06495	COG0601	transmembrane transport
C6P08_RS06500	COG4608	Belongs to the ABC transporter superfamily
C6P08_RS06505	COG0444	Belongs to the ABC transporter superfamily
C6P08_RS06510	COG3935	DnaD domain protein
C6P08_RS06515	COG0017	Asparaginyl-tRNA synthetase
C6P08_RS06520	COG5353	protein conserved in bacteria
C6P08_RS06525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6P08_RS06525	COG1199	ATP-dependent helicase activity
C6P08_RS06545	COG1304	FMN binding
C6P08_RS06560	COG3620	sequence-specific DNA binding
C6P08_RS06575	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C6P08_RS06580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C6P08_RS06585	COG2190	(PTS) system
C6P08_RS06585	COG2211	Major facilitator Superfamily
C6P08_RS06595	COG0028	Belongs to the TPP enzyme family
C6P08_RS06600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C6P08_RS06605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C6P08_RS06610	COG2357	RelA SpoT domain protein
C6P08_RS06630	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C6P08_RS06640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C6P08_RS06650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C6P08_RS06655	COG2384	SAM-dependent methyltransferase
C6P08_RS06660	COG0071	Belongs to the small heat shock protein (HSP20) family
C6P08_RS06665	COG0457	Tetratricopeptide repeat
C6P08_RS06695	COG0419	ATPase involved in DNA repair
C6P08_RS06700	COG0420	3'-5' exonuclease activity
C6P08_RS06710	COG2807	transmembrane transport
C6P08_RS06715	COG4720	Psort location CytoplasmicMembrane, score
C6P08_RS06925	COG1160	GTP binding
C6P08_RS06930	COG0539	negative regulation of cytoplasmic translation
C6P08_RS06935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C6P08_RS06945	COG0514	ATP-dependent DNA helicase (RecQ)
C6P08_RS06955	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C6P08_RS06970	COG1187	pseudouridine synthase activity
C6P08_RS06975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C6P08_RS06980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C6P08_RS06995	COG2996	Protein conserved in bacteria
C6P08_RS07015	COG0475	glutathione-regulated potassium exporter activity
C6P08_RS07025	COG1490	D-aminoacyl-tRNA deacylase activity
C6P08_RS07030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6P08_RS07035	COG0587	DNA-directed DNA polymerase activity
C6P08_RS07050	COG0488	(ABC) transporter
C6P08_RS07055	COG0617	tRNA 3'-terminal CCA addition
C6P08_RS07070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6P08_RS07085	COG0004	ammonium transporteR
C6P08_RS07090	COG1940	carbohydrate kinase activity
C6P08_RS07115	COG0233	cytoplasmic translational termination
C6P08_RS07125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C6P08_RS07130	COG5632	N-Acetylmuramoyl-L-alanine amidase
C6P08_RS07130	COG3409	Peptidoglycan-binding domain 1 protein
C6P08_RS07145	COG2827	Endonuclease containing a URI domain
C6P08_RS07150	COG2890	protein-(glutamine-N5) methyltransferase activity
C6P08_RS07150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C6P08_RS07155	COG0204	Acyl-transferase
C6P08_RS07165	COG3763	UPF0154 protein
C6P08_RS07170	COG4224	UPF0291 protein
C6P08_RS07175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C6P08_RS07185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C6P08_RS07185	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C6P08_RS07190	COG1234	tRNA 3'-trailer cleavage
C6P08_RS07205	COG0484	heat shock protein binding
C6P08_RS07210	COG0443	Heat shock 70 kDa protein
C6P08_RS07220	COG1420	regulation of RNA biosynthetic process
C6P08_RS07260	COG0791	NLP P60 protein
C6P08_RS07260	COG3883	PFAM NLP P60 protein
C6P08_RS07270	COG1216	Glycosyl transferase, family 2
C6P08_RS07275	COG0463	Glycosyl transferase, family 2
C6P08_RS07285	COG0463	Glycosyl transferase, family 2
C6P08_RS07295	COG0562	UDP-galactopyranose mutase
C6P08_RS07330	COG0024	Methionine aminopeptidase
C6P08_RS07360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C6P08_RS07360	COG0463	Glycosyl transferase, family 2
C6P08_RS07365	COG1682	transport, permease protein
C6P08_RS07370	COG1388	LysM domain
C6P08_RS07370	COG1134	teichoic acid transport
C6P08_RS07380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C6P08_RS07385	COG3475	LICD family
C6P08_RS07400	COG1388	LysM domain
C6P08_RS07400	COG1705	Flagellar rod assembly protein muramidase FlgJ
C6P08_RS07405	COG1316	TRANSCRIPTIONal
C6P08_RS07410	COG2246	polysaccharide biosynthetic process
C6P08_RS07420	COG2235	arginine
C6P08_RS07430	COG2801	Transposase and inactivated derivatives
C6P08_RS07445	COG2309	aminopeptidase activity
C6P08_RS07465	COG0564	pseudouridine synthase activity
C6P08_RS07470	COG1278	Cold shock
C6P08_RS07485	COG0741	lytic transglycosylase activity
C6P08_RS07495	COG3973	AAA domain
C6P08_RS07505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C6P08_RS07510	COG1546	Belongs to the CinA family
C6P08_RS07510	COG1058	Belongs to the CinA family
C6P08_RS07520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6P08_RS07525	COG1426	Protein conserved in bacteria
C6P08_RS07530	COG0612	Peptidase, M16
C6P08_RS07535	COG0612	Peptidase, M16
C6P08_RS07555	COG1070	Carbohydrate kinase
C6P08_RS07585	COG4717	serine-type aminopeptidase activity
C6P08_RS07590	COG0420	3'-5' exonuclease activity
C6P08_RS07595	COG3679	Belongs to the UPF0342 family
C6P08_RS07600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6P08_RS07605	COG1438	arginine binding
C6P08_RS07610	COG0306	phosphate transporter
C6P08_RS07615	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C6P08_RS07620	COG0018	arginyl-trna synthetase
C6P08_RS07635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C6P08_RS07645	COG1121	(ABC) transporter
C6P08_RS07650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6P08_RS07660	COG2315	Protein conserved in bacteria
C6P08_RS07680	COG1597	lipid kinase activity
C6P08_RS07685	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6P08_RS07695	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6P08_RS07700	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C6P08_RS07700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C6P08_RS07735	COG1914	H( )-stimulated, divalent metal cation uptake system
C6P08_RS07740	COG0456	acetyltransferase
C6P08_RS07760	COG0667	Aldo Keto reductase
C6P08_RS07765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6P08_RS07770	COG0167	dihydroorotate dehydrogenase activity
C6P08_RS07780	COG1122	ATPase activity
C6P08_RS07790	COG2115	Belongs to the xylose isomerase family
C6P08_RS07795	COG0710	3-dehydroquinate dehydratase activity
C6P08_RS07800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C6P08_RS07805	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6P08_RS07810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C6P08_RS07815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C6P08_RS07820	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C6P08_RS07825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6P08_RS07845	COG2070	2-Nitropropane dioxygenase
C6P08_RS07855	COG0583	DNA-binding transcription factor activity
C6P08_RS07870	COG0438	transferase activity, transferring glycosyl groups
C6P08_RS07885	COG4684	Psort location CytoplasmicMembrane, score
C6P08_RS07890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6P08_RS07895	COG1554	hydrolase, family 65, central catalytic
C6P08_RS07910	COG1609	Transcriptional regulator
C6P08_RS07915	COG0577	efflux transmembrane transporter activity
C6P08_RS07915	COG1136	(ABC) transporter
C6P08_RS07920	COG1136	(ABC) transporter
C6P08_RS07935	COG1131	(ABC) transporter
C6P08_RS07940	COG2188	Transcriptional regulator
C6P08_RS07950	COG0436	Aminotransferase
C6P08_RS07960	COG0596	Alpha beta hydrolase
C6P08_RS07965	COG4166	transmembrane transport
C6P08_RS07980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C6P08_RS07985	COG0436	Aminotransferase
C6P08_RS07990	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C6P08_RS07995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6P08_RS08000	COG1473	amidohydrolase
C6P08_RS08005	COG2171	N-acyltransferase activity
C6P08_RS08010	COG0019	diaminopimelate decarboxylase activity
C6P08_RS08015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6P08_RS08020	COG0527	aspartate kinase activity
C6P08_RS08030	COG1609	Transcriptional regulator
C6P08_RS08035	COG0083	homoserine kinase activity
C6P08_RS08050	COG1321	iron dependent repressor
C6P08_RS08050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6P08_RS08055	COG3764	Sortase (surface protein transpeptidase)
C6P08_RS08060	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C6P08_RS08065	COG0513	Belongs to the DEAD box helicase family
C6P08_RS08070	COG0673	inositol 2-dehydrogenase activity
C6P08_RS08075	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6P08_RS08080	COG0501	Belongs to the peptidase M48B family
C6P08_RS08085	COG1704	LemA family
C6P08_RS08090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6P08_RS08095	COG4115	mRNA cleavage
C6P08_RS08100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6P08_RS08115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C6P08_RS08120	COG0439	Biotin carboxylase
C6P08_RS08135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6P08_RS08140	COG1028	Short-chain dehydrogenase reductase Sdr
C6P08_RS08145	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C6P08_RS08150	COG2070	2-Nitropropane dioxygenase
C6P08_RS08155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6P08_RS08160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C6P08_RS08165	COG1846	Transcriptional regulator
C6P08_RS08170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C6P08_RS08180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C6P08_RS08190	COG1316	TRANSCRIPTIONal
C6P08_RS08195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C6P08_RS08220	COG1215	transferase activity, transferring glycosyl groups
C6P08_RS08225	COG0438	transferase activity, transferring glycosyl groups
C6P08_RS08230	COG0438	transferase activity, transferring glycosyl groups
C6P08_RS08235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6P08_RS08240	COG0489	protein tyrosine kinase activity
C6P08_RS08250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6P08_RS08260	COG0505	Belongs to the CarA family
C6P08_RS08270	COG0564	pseudouridine synthase activity
C6P08_RS08280	COG0328	RNA-DNA hybrid ribonuclease activity
C6P08_RS08285	COG1757	Na H antiporter
C6P08_RS08320	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C6P08_RS08325	COG1113	amino acid transport
C6P08_RS08345	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
C6P08_RS08365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6P08_RS08370	COG1132	(ABC) transporter
C6P08_RS08380	COG0583	DNA-binding transcription factor activity
C6P08_RS08385	COG1811	Na channel or pump
C6P08_RS08390	COG0126	phosphoglycerate kinase activity
C6P08_RS08450	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C6P08_RS08460	COG1696	Membrane protein involved in D-alanine export
C6P08_RS08475	COG0588	phosphoglycerate mutase activity
C6P08_RS08485	COG3716	PTS system mannose fructose sorbose family IID component
C6P08_RS08490	COG3715	PTS system
C6P08_RS08500	COG1027	Aspartate ammonia-lyase
C6P08_RS08570	COG1368	sulfuric ester hydrolase activity
C6P08_RS08585	COG0438	transferase activity, transferring glycosyl groups
C6P08_RS08590	COG0438	transferase activity, transferring glycosyl groups
C6P08_RS08595	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C6P08_RS08600	COG0284	orotidine-5'-phosphate decarboxylase activity
C6P08_RS08605	COG0167	dihydroorotate dehydrogenase activity
C6P08_RS08610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C6P08_RS08615	COG0505	Belongs to the CarA family
C6P08_RS08625	COG0540	Belongs to the ATCase OTCase family
C6P08_RS08650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6P08_RS08655	COG4856	YbbR-like protein
C6P08_RS08670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C6P08_RS08680	COG0456	acetyltransferase
C6P08_RS08685	COG0802	atpase or kinase
C6P08_RS08690	COG0280	phosphate acetyltransferase
C6P08_RS08705	COG2076	Multidrug Resistance protein
C6P08_RS08710	COG2076	Multidrug Resistance protein
C6P08_RS08715	COG1126	abc transporter atp-binding protein
C6P08_RS08720	COG0765	amino acid transport
C6P08_RS08730	COG0557	exoribonuclease II activity
C6P08_RS08740	COG2814	Major facilitator Superfamily
C6P08_RS08750	COG1028	Short-chain dehydrogenase reductase Sdr
C6P08_RS08775	COG0149	triose-phosphate isomerase activity
C6P08_RS08780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6P08_RS08785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6P08_RS08795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C6P08_RS08800	COG0492	ferredoxin-NADP+ reductase activity
C6P08_RS08830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C6P08_RS08835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C6P08_RS08840	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C6P08_RS08855	COG0589	response to stress
C6P08_RS08865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C6P08_RS08870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C6P08_RS08875	COG1177	transmembrane transport
C6P08_RS08885	COG3842	ATPase activity
C6P08_RS08895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C6P08_RS08900	COG0049	tRNA binding
C6P08_RS08905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C6P08_RS08920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C6P08_RS08925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C6P08_RS08930	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C6P08_RS08940	COG1302	Protein conserved in bacteria
C6P08_RS08945	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C6P08_RS08960	COG2017	converts alpha-aldose to the beta-anomer
C6P08_RS08970	COG4975	Glucose uptake
C6P08_RS08975	COG3850	Histidine kinase
C6P08_RS08975	COG5002	protein histidine kinase activity
C6P08_RS08980	COG0745	RESPONSE REGULATOR receiver
C6P08_RS08985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6P08_RS08990	COG0402	S-adenosylhomocysteine deaminase activity
C6P08_RS09005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6P08_RS09020	COG0668	transmembrane transport
C6P08_RS09025	COG0516	GMP reductase activity
C6P08_RS09030	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6P08_RS09060	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C6P08_RS09075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6P08_RS09075	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6P08_RS09105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6P08_RS09125	COG0494	nUDIX hydrolase
C6P08_RS09130	COG1715	Restriction endonuclease
C6P08_RS09145	COG1266	CAAX protease self-immunity
C6P08_RS09155	COG4166	transmembrane transport
C6P08_RS09190	COG0561	phosphatase activity
C6P08_RS09235	COG0577	efflux transmembrane transporter activity
C6P08_RS09240	COG1136	(ABC) transporter
C6P08_RS09250	COG0436	Aminotransferase
C6P08_RS09255	COG3759	membrane
C6P08_RS09260	COG2723	6-phospho-beta-galactosidase activity
C6P08_RS09265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6P08_RS09265	COG1263	PTS System
C6P08_RS09295	COG2814	Major facilitator Superfamily
C6P08_RS09300	COG2217	Heavy metal translocating P-type atpase
C6P08_RS09310	COG0431	NADPH-dependent FMN reductase
C6P08_RS09325	COG2183	response to ionizing radiation
C6P08_RS09335	COG2873	o-acetylhomoserine
C6P08_RS09340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C6P08_RS09350	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C6P08_RS09400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6P08_RS09420	COG1131	(ABC) transporter
C6P08_RS09470	COG2176	DNA-directed DNA polymerase activity
C6P08_RS09475	COG0442	prolyl-tRNA aminoacylation
C6P08_RS09480	COG0750	zinc metalloprotease
C6P08_RS09485	COG4589	Belongs to the CDS family
C6P08_RS09490	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6P08_RS09495	COG0561	phosphatase activity
C6P08_RS09540	COG0656	L-ascorbic acid biosynthetic process
C6P08_RS09550	COG2814	Major facilitator Superfamily
C6P08_RS09570	COG1307	EDD domain protein, DegV family
C6P08_RS09585	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C6P08_RS09590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C6P08_RS09600	COG2252	PERMEase
C6P08_RS09605	COG0352	thiamine-phosphate diphosphorylase activity
C6P08_RS09615	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C6P08_RS09625	COG3594	Acyltransferase
C6P08_RS09630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C6P08_RS09640	COG2188	Transcriptional regulator
C6P08_RS09650	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6P08_RS09660	COG1136	(ABC) transporter
C6P08_RS09660	COG0577	efflux transmembrane transporter activity
C6P08_RS09670	COG0561	phosphatase activity
C6P08_RS09675	COG2169	Transcriptional regulator
C6P08_RS09675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6P08_RS09680	COG0561	phosphatase activity
C6P08_RS09695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C6P08_RS09700	COG0772	Belongs to the SEDS family
C6P08_RS09710	COG1077	Cell shape determining protein MreB Mrl
C6P08_RS09715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C6P08_RS09730	COG1079	Belongs to the binding-protein-dependent transport system permease family
C6P08_RS09735	COG4603	Belongs to the binding-protein-dependent transport system permease family
C6P08_RS09740	COG3845	ABC transporter
C6P08_RS09745	COG1744	ABC transporter substrate-binding protein PnrA-like
C6P08_RS09750	COG1744	ABC transporter substrate-binding protein PnrA-like
C6P08_RS09755	COG1744	ABC transporter substrate-binding protein PnrA-like
C6P08_RS09760	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6P08_RS09770	COG0640	Transcriptional regulator
C6P08_RS09775	COG0628	permease
C6P08_RS09780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C6P08_RS09790	COG0393	Putative heavy-metal-binding
C6P08_RS09795	COG0588	phosphoglycerate mutase activity
C6P08_RS09805	COG0492	ferredoxin-NADP+ reductase activity
C6P08_RS09825	COG1744	ABC transporter substrate-binding protein PnrA-like
C6P08_RS09830	COG1744	ABC transporter substrate-binding protein PnrA-like
C6P08_RS09840	COG2832	Protein of unknown function (DUF454)
C6P08_RS09880	COG2814	Major facilitator Superfamily
C6P08_RS09885	COG0305	Participates in initiation and elongation during chromosome replication
C6P08_RS09890	COG0359	binds to the 23S rRNA
C6P08_RS09900	COG4608	Belongs to the ABC transporter superfamily
C6P08_RS09905	COG0444	Belongs to the ABC transporter superfamily
C6P08_RS09910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6P08_RS09915	COG0601	transmembrane transport
C6P08_RS09920	COG4166	transmembrane transport
C6P08_RS09930	COG1957	nucleoside hydrolase
C6P08_RS09940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C6P08_RS09985	COG1609	Transcriptional regulator
C6P08_RS09990	COG2814	Major facilitator Superfamily
C6P08_RS10000	COG0765	amino acid transport
C6P08_RS10005	COG0765	amino acid transport
C6P08_RS10010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6P08_RS10015	COG1126	abc transporter atp-binding protein
C6P08_RS10030	COG0194	GDP metabolic process
C6P08_RS10035	COG1268	BioY protein
C6P08_RS10060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6P08_RS10065	COG2211	Major facilitator Superfamily
C6P08_RS10070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C6P08_RS10075	COG0673	inositol 2-dehydrogenase activity
C6P08_RS10090	COG3973	AAA domain
C6P08_RS10100	COG2337	Toxic component of a toxin-antitoxin (TA) module
C6P08_RS10105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6P08_RS10145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C6P08_RS10155	COG0504	CTP synthase activity
C6P08_RS10185	COG3343	RNA polymerase activity
C6P08_RS10190	COG0561	phosphatase activity
C6P08_RS10195	COG1078	dGTPase activity
C6P08_RS10205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6P08_RS10210	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C6P08_RS10225	COG5002	protein histidine kinase activity
C6P08_RS10230	COG0745	RESPONSE REGULATOR receiver
C6P08_RS10260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C6P08_RS10265	COG0629	single-stranded DNA binding
C6P08_RS10270	COG0360	Binds together with S18 to 16S ribosomal RNA
C6P08_RS10280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6P08_RS10290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6P08_RS10295	COG1051	belongs to the nudix hydrolase family
C6P08_RS10305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C6P08_RS10310	COG2814	Major facilitator Superfamily
C6P08_RS10315	COG1064	alcohol dehydrogenase
C6P08_RS10320	COG1074	ATP-dependent DNA helicase activity
C6P08_RS10325	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C6P08_RS10330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6P08_RS10335	COG0531	amino acid
C6P08_RS10345	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C6P08_RS10355	COG1902	pentaerythritol trinitrate reductase activity
C6P08_RS10360	COG0626	cystathionine gamma-synthase activity
C6P08_RS10370	COG2244	polysaccharide biosynthetic process
C6P08_RS10380	COG0438	transferase activity, transferring glycosyl groups
C6P08_RS10385	COG0495	leucyl-tRNA aminoacylation
C6P08_RS10390	COG0671	phosphoesterase, PA-phosphatase related
C6P08_RS10400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6P08_RS10420	COG2246	polysaccharide biosynthetic process
C6P08_RS10425	COG1744	ABC transporter substrate-binding protein PnrA-like
C6P08_RS10440	COG1373	ATPase (AAA superfamily
C6P08_RS10450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C6P08_RS10460	COG0024	Methionine aminopeptidase
C6P08_RS10470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6P08_RS10475	COG0737	Belongs to the 5'-nucleotidase family
C6P08_RS10480	COG3639	organic phosphonate transmembrane transporter activity
C6P08_RS10490	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C6P08_RS10500	COG0604	alcohol dehydrogenase
C6P08_RS10505	COG1435	thymidine kinase activity
C6P08_RS10515	COG1316	TRANSCRIPTIONal
C6P08_RS10525	COG2205	protein histidine kinase activity
C6P08_RS10530	COG0745	RESPONSE REGULATOR receiver
C6P08_RS10550	COG1914	H( )-stimulated, divalent metal cation uptake system
C6P08_RS10555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6P08_RS10560	COG0140	phosphoribosyl-ATP diphosphatase activity
C6P08_RS10560	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C6P08_RS10565	COG0107	imidazoleglycerol-phosphate synthase activity
C6P08_RS10570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C6P08_RS10575	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C6P08_RS10580	COG0131	Imidazoleglycerol-phosphate dehydratase
C6P08_RS10585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C6P08_RS10590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C6P08_RS10595	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C6P08_RS10670	COG0438	transferase activity, transferring glycosyl groups
C6P08_RS10675	COG2084	Dehydrogenase
C6P08_RS10685	COG1620	l-lactate permease
C6P08_RS10690	COG4989	oxidoreductase activity
C6P08_RS10695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6P08_RS10700	COG2233	PERMEase
C6P08_RS10720	COG1956	GAF domain-containing protein
C6P08_RS10740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6P08_RS10750	COG1216	Glycosyl transferase, family 2
C6P08_RS10770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C6P08_RS10785	COG2910	NAD(P)H-binding
C6P08_RS10805	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C6P08_RS10810	COG1737	Transcriptional regulator
C6P08_RS10820	COG0656	L-ascorbic acid biosynthetic process
C6P08_RS10825	COG2261	transglycosylase associated protein
C6P08_RS10890	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6P08_RS10895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C6P08_RS10905	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C6P08_RS10920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C6P08_RS10925	COG2244	polysaccharide biosynthetic process
C6P08_RS10930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C6P08_RS10935	COG0193	aminoacyl-tRNA hydrolase activity
C6P08_RS10945	COG0366	Alpha amylase catalytic
C6P08_RS10945	COG3103	Sh3 type 3 domain protein
C6P08_RS10950	COG0058	SHG alpha-glucan phosphorylase activity
C6P08_RS10960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C6P08_RS10970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C6P08_RS10975	COG1511	domain protein
C6P08_RS10980	COG1309	transcriptional regulator
C6P08_RS10995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C6P08_RS11000	COG0477	Major facilitator Superfamily
C6P08_RS11015	COG2115	Belongs to the xylose isomerase family
C6P08_RS11020	COG1940	carbohydrate kinase activity
C6P08_RS11020	COG1846	Transcriptional regulator
C6P08_RS11025	COG2211	Major facilitator Superfamily
C6P08_RS11030	COG3507	Belongs to the glycosyl hydrolase 43 family
C6P08_RS11055	COG1968	undecaprenyl-diphosphatase activity
C6P08_RS11070	COG1695	Transcriptional regulator
C6P08_RS11075	COG1983	PspC domain protein
C6P08_RS11080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C6P08_RS11085	COG1316	TRANSCRIPTIONal
C6P08_RS11095	COG2131	deaminase
C6P08_RS11100	COG4466	Protein conserved in bacteria
C6P08_RS11105	COG1253	flavin adenine dinucleotide binding
C6P08_RS11110	COG1253	flavin adenine dinucleotide binding
C6P08_RS11115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6P08_RS11120	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C6P08_RS11125	COG0084	hydrolase, TatD family'
C6P08_RS11130	COG2801	Transposase and inactivated derivatives
C6P08_RS11145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6P08_RS11145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6P08_RS11175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C6P08_RS11195	COG1368	sulfuric ester hydrolase activity
C6P08_RS11215	COG0187	DNA topoisomerase II activity
C6P08_RS11220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6P08_RS11225	COG2501	S4 domain
C6P08_RS11230	COG0592	DNA-directed DNA polymerase activity
C6P08_RS11240	COG0582	viral genome integration into host DNA
C6P08_RS11255	COG1136	(ABC) transporter
C6P08_RS11260	COG3620	sequence-specific DNA binding
C6P08_RS11265	COG2217	Heavy metal translocating P-type atpase
C6P08_RS11330	COG2261	transglycosylase associated protein