locus-tag	class	description
H9L19_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9L19_RS00030	COG0187	DNA topoisomerase II activity
H9L19_RS00035	COG1739	Uncharacterized protein family UPF0029
H9L19_RS00060	COG1126	abc transporter atp-binding protein
H9L19_RS00090	COG0477	Major facilitator Superfamily
H9L19_RS00110	COG0438	transferase activity, transferring glycosyl groups
H9L19_RS00135	COG1073	alpha beta
H9L19_RS00170	COG0438	transferase activity, transferring glycosyl groups
H9L19_RS00195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9L19_RS00200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9L19_RS00215	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H9L19_RS00220	COG2384	SAM-dependent methyltransferase
H9L19_RS00225	COG0105	UTP biosynthetic process
H9L19_RS00250	COG4720	Psort location CytoplasmicMembrane, score
H9L19_RS00255	COG0351	phosphomethylpyrimidine kinase
H9L19_RS00260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9L19_RS00260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9L19_RS00265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L19_RS00280	COG2217	Heavy metal translocating P-type atpase
H9L19_RS00285	COG0670	Belongs to the BI1 family
H9L19_RS00290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9L19_RS00300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L19_RS00305	COG1363	Peptidase, m42
H9L19_RS00310	COG0572	uridine kinase
H9L19_RS00315	COG5002	protein histidine kinase activity
H9L19_RS00320	COG0745	RESPONSE REGULATOR receiver
H9L19_RS00345	COG0484	heat shock protein binding
H9L19_RS00350	COG0443	Heat shock 70 kDa protein
H9L19_RS00360	COG1420	regulation of RNA biosynthetic process
H9L19_RS00370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9L19_RS00375	COG0358	DNA primase activity
H9L19_RS00385	COG4886	Leucine-rich repeat (LRR) protein
H9L19_RS00385	COG4932	domain protein
H9L19_RS00395	COG2153	protein acetylation
H9L19_RS00415	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H9L19_RS00420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9L19_RS00470	COG0596	Alpha beta hydrolase
H9L19_RS00480	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L19_RS00495	COG0095	Lipoate-protein ligase
H9L19_RS00505	COG0561	phosphatase activity
H9L19_RS00510	COG4975	Glucose uptake
H9L19_RS00520	COG1160	GTP binding
H9L19_RS00525	COG0539	negative regulation of cytoplasmic translation
H9L19_RS00530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9L19_RS00540	COG0514	ATP-dependent DNA helicase (RecQ)
H9L19_RS00550	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H9L19_RS00555	COG1187	pseudouridine synthase activity
H9L19_RS00560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H9L19_RS00565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H9L19_RS00580	COG2996	Protein conserved in bacteria
H9L19_RS00590	COG1490	D-aminoacyl-tRNA deacylase activity
H9L19_RS00595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9L19_RS00600	COG0587	DNA-directed DNA polymerase activity
H9L19_RS00615	COG0488	(ABC) transporter
H9L19_RS00620	COG0617	tRNA 3'-terminal CCA addition
H9L19_RS00625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9L19_RS00640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9L19_RS00645	COG0602	queuosine metabolic process
H9L19_RS00665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9L19_RS00670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H9L19_RS00680	COG1428	Deoxynucleoside kinase
H9L19_RS00690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9L19_RS00695	COG0004	ammonium transporteR
H9L19_RS00705	COG0528	UMP kinase activity
H9L19_RS00710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9L19_RS00725	COG2827	Endonuclease containing a URI domain
H9L19_RS00730	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H9L19_RS00735	COG0204	Acyl-transferase
H9L19_RS00740	COG3763	UPF0154 protein
H9L19_RS00745	COG4224	UPF0291 protein
H9L19_RS00750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9L19_RS00760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H9L19_RS00760	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H9L19_RS00765	COG1234	tRNA 3'-trailer cleavage
H9L19_RS00770	COG1335	isochorismatase
H9L19_RS00775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H9L19_RS00795	COG0024	Methionine aminopeptidase
H9L19_RS00805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9L19_RS00825	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9L19_RS00830	COG1058	Belongs to the CinA family
H9L19_RS00830	COG1546	Belongs to the CinA family
H9L19_RS00835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9L19_RS00840	COG1426	Protein conserved in bacteria
H9L19_RS00845	COG0612	Peptidase, M16
H9L19_RS00855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9L19_RS00865	COG1070	Carbohydrate kinase
H9L19_RS00870	COG2610	gluconate transmembrane transporter activity
H9L19_RS00880	COG1682	transport, permease protein
H9L19_RS00885	COG1388	LysM domain
H9L19_RS00885	COG1134	teichoic acid transport
H9L19_RS00900	COG0196	riboflavin kinase activity
H9L19_RS00905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9L19_RS00920	COG0346	lactoylglutathione lyase activity
H9L19_RS00925	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
H9L19_RS00930	COG1381	Involved in DNA repair and RecF pathway recombination
H9L19_RS00935	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9L19_RS00940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9L19_RS00945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9L19_RS00950	COG1702	phosphate starvation-inducible protein PhoH
H9L19_RS00955	COG1610	YqeY-like protein
H9L19_RS00960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H9L19_RS00975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9L19_RS00980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9L19_RS00985	COG0124	histidyl-tRNA synthetase
H9L19_RS01005	COG3425	synthase
H9L19_RS01010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H9L19_RS01040	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H9L19_RS01055	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
H9L19_RS01060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9L19_RS01075	COG4946	Tricorn protease homolog
H9L19_RS01075	COG0823	Involved in the tonB-independent uptake of proteins
H9L19_RS01075	COG1506	peptidase
H9L19_RS01100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9L19_RS01105	COG1674	ftsk spoiiie
H9L19_RS01110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9L19_RS01115	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9L19_RS01125	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H9L19_RS01130	COG0195	Participates in both transcription termination and antitermination
H9L19_RS01135	COG0779	Required for maturation of 30S ribosomal subunits
H9L19_RS01145	COG1609	Transcriptional regulator
H9L19_RS01150	COG0006	proline dipeptidase activity
H9L19_RS01160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9L19_RS01165	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9L19_RS01175	COG0825	malonyl-CoA metabolic process
H9L19_RS01180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9L19_RS01185	COG0439	Biotin carboxylase
H9L19_RS01200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9L19_RS01205	COG1028	Short-chain dehydrogenase reductase Sdr
H9L19_RS01210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H9L19_RS01220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L19_RS01225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9L19_RS01230	COG1846	Transcriptional regulator
H9L19_RS01235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9L19_RS01245	COG3599	regulation of cell shape
H9L19_RS01260	COG1799	cell septum assembly
H9L19_RS01275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H9L19_RS01280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9L19_RS01285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9L19_RS01290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L19_RS01295	COG0768	penicillin binding
H9L19_RS01305	COG0275	rRNA processing
H9L19_RS01310	COG2001	Belongs to the MraZ family
H9L19_RS01320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9L19_RS01325	COG2264	protein methyltransferase activity
H9L19_RS01330	COG0833	amino acid
H9L19_RS01355	COG1077	Cell shape determining protein MreB Mrl
H9L19_RS01360	COG2003	Belongs to the UPF0758 family
H9L19_RS01365	COG1307	EDD domain protein, DegV family
H9L19_RS01375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9L19_RS01410	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9L19_RS01515	COG1185	polyribonucleotide nucleotidyltransferase activity
H9L19_RS01525	COG0586	Pfam SNARE associated Golgi protein
H9L19_RS01530	COG0628	permease
H9L19_RS01535	COG2706	6-phosphogluconolactonase activity
H9L19_RS01550	COG1597	lipid kinase activity
H9L19_RS01555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L19_RS01570	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9L19_RS01570	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H9L19_RS01580	COG0561	phosphatase activity
H9L19_RS01585	COG0667	Aldo Keto reductase
H9L19_RS01590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9L19_RS01595	COG4721	ABC-type cobalt transport system, permease component
H9L19_RS01600	COG1122	ATPase activity
H9L19_RS01620	COG2814	Major facilitator Superfamily
H9L19_RS01635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9L19_RS01640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9L19_RS01645	COG1230	cation diffusion facilitator family transporter
H9L19_RS01650	COG4684	Psort location CytoplasmicMembrane, score
H9L19_RS01655	COG0436	Aminotransferase
H9L19_RS01660	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H9L19_RS01665	COG3557	Belongs to the UPF0374 family
H9L19_RS01670	COG2137	regulation of response to DNA damage stimulus
H9L19_RS01675	COG0488	(ABC) transporter
H9L19_RS01680	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H9L19_RS01685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9L19_RS01700	COG2226	methyltransferase
H9L19_RS01705	COG0799	negative regulation of ribosome biogenesis
H9L19_RS01710	COG1713	HD superfamily hydrolase involved in NAD metabolism
H9L19_RS01715	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H9L19_RS01725	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H9L19_RS01730	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H9L19_RS01740	COG0126	phosphoglycerate kinase activity
H9L19_RS01790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9L19_RS01795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L19_RS01805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9L19_RS01810	COG0492	ferredoxin-NADP+ reductase activity
H9L19_RS01815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H9L19_RS01820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9L19_RS01825	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H9L19_RS01830	COG1950	PFAM Membrane protein of
H9L19_RS01835	COG2814	Major facilitator Superfamily
H9L19_RS01850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L19_RS01855	COG4493	Belongs to the UPF0637 family
H9L19_RS01865	COG1177	transmembrane transport
H9L19_RS01875	COG3842	ATPase activity
H9L19_RS01880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9L19_RS01885	COG0049	tRNA binding
H9L19_RS01900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H9L19_RS01905	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9L19_RS01910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H9L19_RS01915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L19_RS01920	COG1302	Protein conserved in bacteria
H9L19_RS01925	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9L19_RS01935	COG0166	Belongs to the GPI family
H9L19_RS01940	COG2017	converts alpha-aldose to the beta-anomer
H9L19_RS01945	COG5002	protein histidine kinase activity
H9L19_RS01945	COG3850	Histidine kinase
H9L19_RS01950	COG0745	RESPONSE REGULATOR receiver
H9L19_RS01955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9L19_RS01965	COG0402	S-adenosylhomocysteine deaminase activity
H9L19_RS01970	COG1902	pentaerythritol trinitrate reductase activity
H9L19_RS01975	COG0628	permease
H9L19_RS01985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L19_RS02005	COG1929	Belongs to the glycerate kinase type-1 family
H9L19_RS02015	COG2217	Heavy metal translocating P-type atpase
H9L19_RS02050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9L19_RS02055	COG2217	Heavy metal translocating P-type atpase
H9L19_RS02070	COG1882	Formate acetyltransferase
H9L19_RS02075	COG2183	response to ionizing radiation
H9L19_RS02090	COG1278	Cold shock
H9L19_RS02100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H9L19_RS02105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9L19_RS02115	COG0305	Participates in initiation and elongation during chromosome replication
H9L19_RS02120	COG0359	binds to the 23S rRNA
H9L19_RS02130	COG4608	Belongs to the ABC transporter superfamily
H9L19_RS02140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L19_RS02145	COG0601	transmembrane transport
H9L19_RS02150	COG4166	transmembrane transport
H9L19_RS02155	COG4166	transmembrane transport
H9L19_RS02160	COG0765	amino acid transport
H9L19_RS02165	COG0765	amino acid transport
H9L19_RS02175	COG1126	abc transporter atp-binding protein
H9L19_RS02180	COG0194	GDP metabolic process
H9L19_RS02185	COG1268	BioY protein
H9L19_RS02205	COG1136	(ABC) transporter
H9L19_RS02205	COG0577	efflux transmembrane transporter activity
H9L19_RS02210	COG1132	(ABC) transporter
H9L19_RS02215	COG1132	(ABC) transporter
H9L19_RS02220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9L19_RS02225	COG0588	phosphoglycerate mutase activity
H9L19_RS02255	COG0708	Exodeoxyribonuclease III
H9L19_RS02275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H9L19_RS02280	COG0772	Belongs to the SEDS family
H9L19_RS02290	COG1077	Cell shape determining protein MreB Mrl
H9L19_RS02295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9L19_RS02300	COG1136	(ABC) transporter
H9L19_RS02305	COG0577	efflux transmembrane transporter activity
H9L19_RS02310	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L19_RS02320	COG0390	transport system, permease component
H9L19_RS02325	COG4619	ABC transporter
H9L19_RS02330	COG0737	Belongs to the 5'-nucleotidase family
H9L19_RS02335	COG0588	phosphoglycerate mutase activity
H9L19_RS02340	COG0492	ferredoxin-NADP+ reductase activity
H9L19_RS02355	COG1733	regulation of RNA biosynthetic process
H9L19_RS02360	COG0477	Major facilitator Superfamily
H9L19_RS02370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L19_RS02375	COG0583	DNA-binding transcription factor activity
H9L19_RS02380	COG0281	malic enzyme
H9L19_RS02405	COG0653	protein targeting
H9L19_RS02410	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H9L19_RS02420	COG1696	Membrane protein involved in D-alanine export
H9L19_RS02425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H9L19_RS02455	COG2337	Toxic component of a toxin-antitoxin (TA) module
H9L19_RS02460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9L19_RS02485	COG1078	dGTPase activity
H9L19_RS02500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9L19_RS02505	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H9L19_RS02520	COG5002	protein histidine kinase activity
H9L19_RS02525	COG0745	RESPONSE REGULATOR receiver
H9L19_RS02550	COG4464	protein tyrosine phosphatase activity
H9L19_RS02555	COG0489	protein tyrosine kinase activity
H9L19_RS02565	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H9L19_RS02570	COG0629	single-stranded DNA binding
H9L19_RS02575	COG0360	Binds together with S18 to 16S ribosomal RNA
H9L19_RS02580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9L19_RS02590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9L19_RS02595	COG2814	Major facilitator Superfamily
H9L19_RS02610	COG1074	ATP-dependent DNA helicase activity
H9L19_RS02615	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H9L19_RS02625	COG2813	Specifically methylates the guanine in position
H9L19_RS02690	COG1064	alcohol dehydrogenase
H9L19_RS02695	COG0203	ribosomal protein L17
H9L19_RS02700	COG0202	RNA polymerase activity
H9L19_RS02705	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9L19_RS02710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9L19_RS02715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9L19_RS02725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9L19_RS02730	COG0563	adenylate kinase activity
H9L19_RS02740	COG0200	Binds to the 23S rRNA
H9L19_RS02745	COG1841	ribosomal large subunit assembly
H9L19_RS02750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H9L19_RS02755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H9L19_RS02760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9L19_RS02765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9L19_RS02770	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9L19_RS02775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9L19_RS02780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9L19_RS02790	COG0255	Belongs to the universal ribosomal protein uL29 family
H9L19_RS02795	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H9L19_RS02800	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9L19_RS02805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9L19_RS02810	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9L19_RS02815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9L19_RS02820	COG0089	rRNA binding
H9L19_RS02830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9L19_RS02835	COG0051	transcription antitermination factor activity, RNA binding
H9L19_RS02840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9L19_RS02855	COG1214	PFAM Peptidase M22, glycoprotease
H9L19_RS02880	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9L19_RS02885	COG1428	Deoxynucleoside kinase
H9L19_RS02890	COG1388	LysM domain
H9L19_RS02890	COG3942	CHAP domain
H9L19_RS02895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H9L19_RS02900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9L19_RS02905	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9L19_RS02910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9L19_RS02915	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L19_RS02920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H9L19_RS02925	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L19_RS02930	COG0356	it plays a direct role in the translocation of protons across the membrane
H9L19_RS02940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9L19_RS02945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9L19_RS02950	COG0009	L-threonylcarbamoyladenylate synthase
H9L19_RS02955	COG2890	protein-(glutamine-N5) methyltransferase activity
H9L19_RS02960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9L19_RS02965	COG1435	thymidine kinase activity
H9L19_RS02970	COG3442	glutamine amidotransferase
H9L19_RS02975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9L19_RS02985	COG0531	amino acid
H9L19_RS03000	COG0500	methyltransferase
H9L19_RS03010	COG0531	amino acid
H9L19_RS03015	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H9L19_RS03035	COG2244	polysaccharide biosynthetic process
H9L19_RS03050	COG0495	leucyl-tRNA aminoacylation
H9L19_RS03055	COG0671	phosphoesterase, PA-phosphatase related
H9L19_RS03065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L19_RS03075	COG1114	Component of the transport system for branched-chain amino acids
H9L19_RS03080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9L19_RS03085	COG0392	lysyltransferase activity
H9L19_RS03085	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H9L19_RS03100	COG0351	phosphomethylpyrimidine kinase
H9L19_RS03105	COG0222	ribosome binding
H9L19_RS03110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9L19_RS03115	COG0081	regulation of translation
H9L19_RS03120	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9L19_RS03140	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9L19_RS03150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L19_RS03155	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H9L19_RS03165	COG1122	ATPase activity
H9L19_RS03170	COG4720	Psort location CytoplasmicMembrane, score
H9L19_RS03190	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H9L19_RS03200	COG0215	cysteine-tRNA ligase activity
H9L19_RS03205	COG3548	integral membrane protein
H9L19_RS03215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H9L19_RS03230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9L19_RS03240	COG1482	cell wall glycoprotein biosynthetic process
H9L19_RS03250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H9L19_RS03260	COG0011	TIGRFAM Protein of
H9L19_RS03300	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
H9L19_RS03310	COG2188	Transcriptional regulator
H9L19_RS03315	COG2814	Major facilitator Superfamily
H9L19_RS03335	COG0534	Mate efflux family protein
H9L19_RS03340	COG0488	(ABC) transporter
H9L19_RS03345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9L19_RS03350	COG1121	(ABC) transporter
H9L19_RS03375	COG3104	oligopeptide transport
H9L19_RS03395	COG2211	Major facilitator Superfamily
H9L19_RS03400	COG5002	protein histidine kinase activity
H9L19_RS03415	COG0012	GTP binding
H9L19_RS03420	COG4481	Protein conserved in bacteria
H9L19_RS03425	COG1475	DNA binding
H9L19_RS03430	COG1192	Involved in chromosome partitioning
H9L19_RS03440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9L19_RS03445	COG0436	Aminotransferase
H9L19_RS03465	COG2115	Belongs to the xylose isomerase family
H9L19_RS03470	COG2211	Major facilitator Superfamily
H9L19_RS03475	COG1846	Transcriptional regulator
H9L19_RS03475	COG1940	carbohydrate kinase activity
H9L19_RS03480	COG2855	membrane
H9L19_RS03485	COG1464	Belongs to the NlpA lipoprotein family
H9L19_RS03490	COG0531	amino acid
H9L19_RS03505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9L19_RS03515	COG0657	acetylesterase activity
H9L19_RS03520	COG1113	amino acid transport
H9L19_RS03535	COG0628	permease
H9L19_RS03540	COG1254	Belongs to the acylphosphatase family
H9L19_RS03545	COG1309	transcriptional regulator
H9L19_RS03550	COG0656	L-ascorbic acid biosynthetic process
H9L19_RS03555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L19_RS03595	COG0328	RNA-DNA hybrid ribonuclease activity
H9L19_RS03605	COG0561	phosphatase activity
H9L19_RS03610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9L19_RS03615	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9L19_RS03620	COG0569	domain protein
H9L19_RS03625	COG1113	amino acid transport
H9L19_RS03640	COG0594	ribonuclease P activity
H9L19_RS03645	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H9L19_RS03650	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9L19_RS03655	COG0592	DNA-directed DNA polymerase activity
H9L19_RS03660	COG2501	S4 domain
H9L19_RS03665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9L19_RS03670	COG0187	DNA topoisomerase II activity
H9L19_RS03685	COG0454	-acetyltransferase
H9L19_RS03690	COG1368	sulfuric ester hydrolase activity
H9L19_RS03735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L19_RS03735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L19_RS03740	COG0084	hydrolase, TatD family'
H9L19_RS03745	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H9L19_RS03750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9L19_RS03755	COG1253	flavin adenine dinucleotide binding
H9L19_RS03765	COG2131	deaminase
H9L19_RS03775	COG1316	TRANSCRIPTIONal
H9L19_RS03790	COG1968	undecaprenyl-diphosphatase activity
H9L19_RS03800	COG3835	regulator
H9L19_RS03805	COG2235	arginine
H9L19_RS03810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9L19_RS03865	COG2309	aminopeptidase activity
H9L19_RS03875	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H9L19_RS03890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H9L19_RS03895	COG0252	asparaginase activity
H9L19_RS03905	COG0745	RESPONSE REGULATOR receiver
H9L19_RS03910	COG5002	protein histidine kinase activity
H9L19_RS03915	COG1881	PFAM PEBP family protein
H9L19_RS03940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L19_RS03950	COG3118	belongs to the thioredoxin family
H9L19_RS03965	COG0193	aminoacyl-tRNA hydrolase activity
H9L19_RS03975	COG2244	polysaccharide biosynthetic process
H9L19_RS03980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H9L19_RS04015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9L19_RS04020	COG1609	Transcriptional regulator
H9L19_RS04040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H9L19_RS04045	COG0393	Putative heavy-metal-binding
H9L19_RS04085	COG0028	Belongs to the TPP enzyme family
H9L19_RS04095	COG0640	Transcriptional regulator
H9L19_RS04100	COG1113	amino acid transport
H9L19_RS04115	COG1737	Transcriptional regulator
H9L19_RS04120	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H9L19_RS04145	COG1846	Transcriptional regulator
H9L19_RS04155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H9L19_RS04165	COG0656	L-ascorbic acid biosynthetic process
H9L19_RS04190	COG4463	regulation of RNA biosynthetic process
H9L19_RS04195	COG0542	response to heat
H9L19_RS04200	COG0085	RNA polymerase activity
H9L19_RS04205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9L19_RS04225	COG1956	GAF domain-containing protein
H9L19_RS04230	COG1063	alcohol dehydrogenase
H9L19_RS04235	COG2233	PERMEase
H9L19_RS04240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9L19_RS04250	COG3590	peptidase
H9L19_RS04255	COG1454	alcohol dehydrogenase
H9L19_RS04255	COG1012	belongs to the aldehyde dehydrogenase family
H9L19_RS04265	COG1252	NADH dehydrogenase
H9L19_RS04270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L19_RS04275	COG1122	ATPase activity
H9L19_RS04280	COG1122	ATPase activity
H9L19_RS04290	COG0101	tRNA pseudouridine synthase activity
H9L19_RS04300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H9L19_RS04305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9L19_RS04315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9L19_RS04320	COG3870	Protein conserved in bacteria
H9L19_RS04325	COG0470	DNA polymerase III
H9L19_RS04340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9L19_RS04355	COG0656	L-ascorbic acid biosynthetic process
H9L19_RS04360	COG1620	l-lactate permease
H9L19_RS04375	COG0438	transferase activity, transferring glycosyl groups
H9L19_RS04380	COG0438	transferase activity, transferring glycosyl groups
H9L19_RS04435	COG1194	a g-specific adenine glycosylase
H9L19_RS04440	COG0531	amino acid
H9L19_RS04445	COG0626	cystathionine gamma-synthase activity
H9L19_RS04455	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H9L19_RS04460	COG1263	PTS System
H9L19_RS04460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L19_RS04490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9L19_RS04495	COG0514	ATP-dependent DNA helicase (RecQ)
H9L19_RS04525	COG0662	Cupin 2, conserved barrel domain protein
H9L19_RS04525	COG2207	Transcriptional regulator
H9L19_RS04550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9L19_RS04580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9L19_RS04590	COG0531	amino acid
H9L19_RS04600	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9L19_RS04605	COG3507	Belongs to the glycosyl hydrolase 43 family
H9L19_RS04615	COG1914	H( )-stimulated, divalent metal cation uptake system
H9L19_RS04625	COG1660	Displays ATPase and GTPase activities
H9L19_RS04630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H9L19_RS04635	COG1481	regulation of sporulation
H9L19_RS04640	COG0740	serine-type endopeptidase activity
H9L19_RS04655	COG0601	transmembrane transport
H9L19_RS04660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L19_RS04665	COG0747	negative chemotaxis
H9L19_RS04670	COG3759	membrane
H9L19_RS04675	COG3189	MarR family transcriptional regulator
H9L19_RS04710	COG2361	Protein of unknown function DUF86
H9L19_RS04745	COG0433	COG0433 Predicted ATPase
H9L19_RS04755	COG1674	ftsk spoiiie
H9L19_RS04830	COG1846	Transcriptional regulator
H9L19_RS04870	COG0542	response to heat
H9L19_RS04880	COG0756	dUTP diphosphatase activity
H9L19_RS04890	COG4956	integral membrane protein (PIN domain superfamily)
H9L19_RS04895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9L19_RS04900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9L19_RS04905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L19_RS04905	COG0072	phenylalanine-tRNA ligase activity
H9L19_RS04910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H9L19_RS04920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9L19_RS04930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9L19_RS04945	COG1940	carbohydrate kinase activity
H9L19_RS04970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9L19_RS04975	COG0789	Transcriptional regulator
H9L19_RS05000	COG0697	spore germination
H9L19_RS05005	COG4708	membrane
H9L19_RS05050	COG0488	(ABC) transporter
H9L19_RS05070	COG2188	Transcriptional regulator
H9L19_RS05080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9L19_RS05085	COG2252	PERMEase
H9L19_RS05095	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H9L19_RS05125	COG0561	phosphatase activity
H9L19_RS05130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9L19_RS05140	COG0750	zinc metalloprotease
H9L19_RS05155	COG2176	DNA-directed DNA polymerase activity
H9L19_RS05185	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H9L19_RS05190	COG1040	competence protein
H9L19_RS05195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9L19_RS05200	COG0006	proline dipeptidase activity
H9L19_RS05210	COG0737	Belongs to the 5'-nucleotidase family
H9L19_RS05215	COG4470	Protein conserved in bacteria
H9L19_RS05220	COG0647	UMP catabolic process
H9L19_RS05230	COG0573	inorganic phosphate transmembrane transporter activity
H9L19_RS05235	COG0581	inorganic phosphate transmembrane transporter activity
H9L19_RS05245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9L19_RS05250	COG0704	Plays a role in the regulation of phosphate uptake
H9L19_RS05255	COG2910	NAD(P)H-binding
H9L19_RS05270	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H9L19_RS05300	COG0557	exoribonuclease II activity
H9L19_RS05305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H9L19_RS05310	COG4221	oxidoreductase activity
H9L19_RS05315	COG0765	amino acid transport
H9L19_RS05320	COG1126	abc transporter atp-binding protein
H9L19_RS05325	COG0673	inositol 2-dehydrogenase activity
H9L19_RS05355	COG0280	phosphate acetyltransferase
H9L19_RS05360	COG0802	atpase or kinase
H9L19_RS05375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9L19_RS05380	COG0025	NhaP-type Na H and K H
H9L19_RS05405	COG0540	Belongs to the ATCase OTCase family
H9L19_RS05415	COG0505	Belongs to the CarA family
H9L19_RS05420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9L19_RS05425	COG0167	dihydroorotate dehydrogenase activity
H9L19_RS05430	COG0284	orotidine-5'-phosphate decarboxylase activity
H9L19_RS05435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9L19_RS05440	COG0438	transferase activity, transferring glycosyl groups
H9L19_RS05460	COG1368	sulfuric ester hydrolase activity
H9L19_RS05500	COG3142	Participates in the control of copper homeostasis
H9L19_RS05555	COG1027	Aspartate ammonia-lyase
H9L19_RS05565	COG3715	PTS system
H9L19_RS05570	COG3716	PTS system mannose fructose sorbose family IID component
H9L19_RS05580	COG3973	AAA domain
H9L19_RS05585	COG1072	(Pantothenic acid kinase))
H9L19_RS05590	COG0741	lytic transglycosylase activity
H9L19_RS05595	COG1970	mechanosensitive ion channel activity
H9L19_RS05600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H9L19_RS05605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H9L19_RS05610	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9L19_RS05615	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9L19_RS05620	COG0047	phosphoribosylformylglycinamidine synthase activity
H9L19_RS05625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9L19_RS05635	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9L19_RS05640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H9L19_RS05645	COG0138	bifunctional purine biosynthesis protein purh
H9L19_RS05655	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H9L19_RS05660	COG1418	mRNA catabolic process
H9L19_RS05665	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H9L19_RS05670	COG0459	protein refolding
H9L19_RS05690	COG4720	Psort location CytoplasmicMembrane, score
H9L19_RS05695	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9L19_RS05700	COG4807	Protein conserved in bacteria
H9L19_RS05705	COG0716	FMN binding
H9L19_RS05710	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9L19_RS05715	COG1609	Transcriptional regulator
H9L19_RS05735	COG2017	converts alpha-aldose to the beta-anomer
H9L19_RS05740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9L19_RS05745	COG4720	Psort location CytoplasmicMembrane, score
H9L19_RS05755	COG4120	Belongs to the binding-protein-dependent transport system permease family
H9L19_RS05780	COG1609	Transcriptional regulator
H9L19_RS05795	COG2160	L-arabinose isomerase activity
H9L19_RS05805	COG0656	L-ascorbic acid biosynthetic process
H9L19_RS05810	COG0527	aspartate kinase activity
H9L19_RS05815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9L19_RS05830	COG1473	amidohydrolase
H9L19_RS05835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9L19_RS05845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9L19_RS05850	COG2084	Dehydrogenase
H9L19_RS05855	COG0436	Aminotransferase
H9L19_RS05860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L19_RS05870	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H9L19_RS05910	COG1272	protein, Hemolysin III
H9L19_RS05915	COG0525	valine-tRNA ligase activity
H9L19_RS05945	COG1121	(ABC) transporter
H9L19_RS05950	COG3842	ATPase activity
H9L19_RS05960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L19_RS05965	COG0673	inositol 2-dehydrogenase activity
H9L19_RS05970	COG0513	Belongs to the DEAD box helicase family
H9L19_RS05975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9L19_RS05995	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H9L19_RS06000	COG1438	arginine binding
H9L19_RS06005	COG0497	DNA recombination
H9L19_RS06010	COG0194	GDP metabolic process
H9L19_RS06015	COG1758	RNA polymerase activity
H9L19_RS06030	COG0562	UDP-galactopyranose mutase
H9L19_RS06040	COG2357	RelA SpoT domain protein
H9L19_RS06050	COG0564	pseudouridine synthase activity
H9L19_RS06055	COG2239	Acts as a magnesium transporter
H9L19_RS06060	COG2814	Major facilitator Superfamily
H9L19_RS06065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9L19_RS06070	COG4472	Bacterial protein of unknown function (DUF965)
H9L19_RS06080	COG3906	Belongs to the UPF0473 family
H9L19_RS06085	COG3906	Belongs to the UPF0473 family
H9L19_RS06090	COG1695	Transcriptional regulator
H9L19_RS06110	COG1555	photosystem II stabilization
H9L19_RS06110	COG1596	polysaccharide export
H9L19_RS06120	COG1466	dna polymerase III delta subunit
H9L19_RS06125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H9L19_RS06130	COG0268	Binds directly to 16S ribosomal RNA
H9L19_RS06135	COG1136	(ABC) transporter
H9L19_RS06145	COG1438	arginine binding
H9L19_RS06150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9L19_RS06155	COG3679	Belongs to the UPF0342 family
H9L19_RS06165	COG4717	serine-type aminopeptidase activity
H9L19_RS06170	COG3481	metal-dependent phosphohydrolase, HD sub domain
H9L19_RS06175	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H9L19_RS06185	COG0335	large ribosomal subunit rRNA binding
H9L19_RS06200	COG0582	viral genome integration into host DNA
H9L19_RS06225	COG3152	Membrane
H9L19_RS06230	COG1395	domain, Protein
H9L19_RS06300	COG0629	single-stranded DNA binding
H9L19_RS06395	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H9L19_RS06400	COG3421	Type III restriction
H9L19_RS06405	COG0456	acetyltransferase
H9L19_RS06445	COG0346	lactoylglutathione lyase activity
H9L19_RS06450	COG2207	Transcriptional regulator
H9L19_RS06455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L19_RS06465	COG2723	6-phospho-beta-galactosidase activity
H9L19_RS06470	COG2723	6-phospho-beta-galactosidase activity
H9L19_RS06475	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L19_RS06485	COG0363	glucosamine-6-phosphate deaminase activity
H9L19_RS06490	COG0561	phosphatase activity
H9L19_RS06530	COG3507	Belongs to the glycosyl hydrolase 43 family
H9L19_RS06570	COG0564	pseudouridine synthase activity
H9L19_RS06580	COG0505	Belongs to the CarA family
H9L19_RS06585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9L19_RS06590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9L19_RS06595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9L19_RS06605	COG1304	FMN binding
H9L19_RS06620	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H9L19_RS06625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9L19_RS06625	COG1199	ATP-dependent helicase activity
H9L19_RS06635	COG0017	Asparaginyl-tRNA synthetase
H9L19_RS06640	COG4974	Belongs to the 'phage' integrase family
H9L19_RS06715	COG0629	single-stranded DNA binding
H9L19_RS06900	COG0039	L-malate dehydrogenase activity
H9L19_RS06905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9L19_RS06915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9L19_RS06915	COG2169	Transcriptional regulator
H9L19_RS06920	COG1970	mechanosensitive ion channel activity
H9L19_RS06930	COG1393	Belongs to the ArsC family
H9L19_RS06935	COG4862	establishment of competence for transformation
H9L19_RS06940	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L19_RS06945	COG1447	Phosphotransferase system cellobiose-specific component IIA
H9L19_RS06960	COG1164	Oligoendopeptidase f
H9L19_RS06975	COG0752	glycyl-tRNA synthetase alpha subunit
H9L19_RS06980	COG0751	glycine-tRNA ligase activity
H9L19_RS06985	COG2814	Major facilitator Superfamily
H9L19_RS06990	COG0516	GMP reductase activity
H9L19_RS06990	COG0517	IMP dehydrogenase activity
H9L19_RS07015	COG0765	amino acid transport
H9L19_RS07020	COG1126	abc transporter atp-binding protein
H9L19_RS07025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9L19_RS07030	COG2814	Major facilitator Superfamily
H9L19_RS07040	COG3331	DNA recombination
H9L19_RS07045	COG4474	Belongs to the UPF0398 family
H9L19_RS07050	COG3599	regulation of cell shape
H9L19_RS07060	COG0116	Belongs to the methyltransferase superfamily
H9L19_RS07070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9L19_RS07090	COG1132	(ABC) transporter
H9L19_RS07095	COG0556	nucleotide-excision repair
H9L19_RS07105	COG0537	adenosine 5'-monophosphoramidase activity
H9L19_RS07110	COG1131	(ABC) transporter
H9L19_RS07120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9L19_RS07125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9L19_RS07130	COG4974	Belongs to the 'phage' integrase family
H9L19_RS07140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9L19_RS07145	COG0237	dephospho-CoA kinase activity
H9L19_RS07150	COG3611	Membrane attachment protein
H9L19_RS07155	COG1484	DNA-dependent DNA replication
H9L19_RS07170	COG0745	RESPONSE REGULATOR receiver
H9L19_RS07175	COG5002	protein histidine kinase activity
H9L19_RS07180	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L19_RS07190	COG0719	Fe-S assembly protein
H9L19_RS07195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9L19_RS07200	COG0822	iron-sulfur transferase activity
H9L19_RS07205	COG0719	Fe-S assembly protein
H9L19_RS07210	COG2151	metal-sulfur cluster biosynthetic enzyme
H9L19_RS07230	COG1307	EDD domain protein, DegV family
H9L19_RS07235	COG1307	EDD domain protein, DegV family
H9L19_RS07240	COG2755	lipolytic protein G-D-S-L family
H9L19_RS07250	COG4479	Belongs to the UPF0346 family
H9L19_RS07260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9L19_RS07265	COG0758	DNA mediated transformation
H9L19_RS07275	COG1757	Na H antiporter
H9L19_RS07280	COG0632	four-way junction helicase activity
H9L19_RS07285	COG2255	four-way junction helicase activity
H9L19_RS07290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9L19_RS07300	COG1862	Preprotein translocase
H9L19_RS07305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9L19_RS07310	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H9L19_RS07315	COG0513	Belongs to the DEAD box helicase family
H9L19_RS07320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9L19_RS07325	COG1942	4-Oxalocrotonate Tautomerase
H9L19_RS07345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9L19_RS07375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9L19_RS07380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H9L19_RS07385	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9L19_RS07390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9L19_RS07390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L19_RS07395	COG0631	protein serine/threonine phosphatase activity
H9L19_RS07400	COG0515	serine threonine protein kinase
H9L19_RS07400	COG2815	serine threonine protein kinase
H9L19_RS07405	COG1162	GTPase activity
H9L19_RS07410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9L19_RS07415	COG1564	THIamine pyrophosphokinase
H9L19_RS07420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9L19_RS07430	COG1461	Dihydroxyacetone kinase
H9L19_RS07435	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H9L19_RS07455	COG0463	Glycosyl transferase, family 2
H9L19_RS07460	COG1088	dTDP-glucose 4,6-dehydratase activity
H9L19_RS07480	COG4989	oxidoreductase activity
H9L19_RS07495	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9L19_RS07500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9L19_RS07505	COG1704	LemA family
H9L19_RS07510	COG0501	Belongs to the peptidase M48B family
H9L19_RS07535	COG0018	arginyl-trna synthetase
H9L19_RS07560	COG2252	PERMEase
H9L19_RS07565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H9L19_RS07570	COG3940	Belongs to the glycosyl hydrolase 43 family
H9L19_RS07575	COG2211	Major facilitator Superfamily
H9L19_RS07580	COG0416	fatty acid biosynthetic process
H9L19_RS07585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L19_RS07590	COG0571	ribonuclease III activity
H9L19_RS07595	COG1196	nuclear chromosome segregation
H9L19_RS07600	COG0552	protein localization to endoplasmic reticulum
H9L19_RS07605	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H9L19_RS07610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9L19_RS07615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9L19_RS07620	COG0228	four-way junction DNA binding
H9L19_RS07630	COG1511	domain protein
H9L19_RS07635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9L19_RS07640	COG0336	Belongs to the RNA methyltransferase TrmD family
H9L19_RS07650	COG0463	Glycosyl transferase, family 2
H9L19_RS07655	COG0110	maltose O-acetyltransferase activity
H9L19_RS07670	COG0561	phosphatase activity
H9L19_RS07705	COG1869	D-ribose catabolic process
H9L19_RS07715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9L19_RS07720	COG3842	ATPase activity
H9L19_RS07725	COG1175	transmembrane transport
H9L19_RS07740	COG0584	glycerophosphoryl diester phosphodiesterase
H9L19_RS07765	COG0789	Transcriptional regulator
H9L19_RS07785	COG4221	oxidoreductase activity
H9L19_RS07790	COG1979	alcohol dehydrogenase
H9L19_RS07795	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9L19_RS07845	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9L19_RS07875	COG1917	Cupin 2, conserved barrel domain protein
H9L19_RS07875	COG2169	Transcriptional regulator
H9L19_RS07900	COG1309	transcriptional regulator
H9L19_RS07910	COG1131	(ABC) transporter
H9L19_RS07925	COG2261	transglycosylase associated protein
H9L19_RS07940	COG0577	efflux transmembrane transporter activity
H9L19_RS07940	COG1136	(ABC) transporter
H9L19_RS08015	COG0110	maltose O-acetyltransferase activity
H9L19_RS08045	COG0456	acetyltransferase
H9L19_RS08050	COG3091	SprT-like family
H9L19_RS08060	COG0167	dihydroorotate dehydrogenase activity
H9L19_RS08070	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9L19_RS08085	COG1028	Short-chain dehydrogenase reductase Sdr
H9L19_RS08090	COG0706	membrane insertase activity
H9L19_RS08095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L19_RS08130	COG0765	amino acid transport
H9L19_RS08135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9L19_RS08145	COG3480	Lon protease (S16) C-terminal proteolytic domain
H9L19_RS08150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H9L19_RS08155	COG0742	ribosomal rna small subunit methyltransferase
H9L19_RS08160	COG4471	UPF0298 protein
H9L19_RS08165	COG0772	Belongs to the SEDS family
H9L19_RS08170	COG1217	gtp-binding protein TYPA
H9L19_RS08175	COG0483	inositol monophosphate 1-phosphatase activity
H9L19_RS08185	COG0242	peptide deformylase activity
H9L19_RS08195	COG1876	peptidase activity
H9L19_RS08200	COG5503	Protein of unknown function (DUF1447)