locus-tag	class	description
KHQ32_RS00005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KHQ32_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KHQ32_RS00020	COG2501	S4 domain
KHQ32_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KHQ32_RS00030	COG0187	DNA topoisomerase II activity
KHQ32_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KHQ32_RS00040	COG1368	sulfuric ester hydrolase activity
KHQ32_RS00105	COG1737	Transcriptional regulator
KHQ32_RS00110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KHQ32_RS00135	COG2233	PERMEase
KHQ32_RS00140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KHQ32_RS00145	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KHQ32_RS00190	COG2252	PERMEase
KHQ32_RS00200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KHQ32_RS00215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KHQ32_RS00220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KHQ32_RS00230	COG2818	Glycosylase
KHQ32_RS00240	COG0495	leucyl-tRNA aminoacylation
KHQ32_RS00250	COG2244	polysaccharide biosynthetic process
KHQ32_RS00265	COG0531	amino acid
KHQ32_RS00275	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KHQ32_RS00280	COG1074	ATP-dependent DNA helicase activity
KHQ32_RS00285	COG1064	alcohol dehydrogenase
KHQ32_RS00300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KHQ32_RS00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KHQ32_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KHQ32_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KHQ32_RS00320	COG4493	Belongs to the UPF0637 family
KHQ32_RS00325	COG0360	Binds together with S18 to 16S ribosomal RNA
KHQ32_RS00330	COG0629	single-stranded DNA binding
KHQ32_RS00335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KHQ32_RS00350	COG0745	RESPONSE REGULATOR receiver
KHQ32_RS00355	COG5002	protein histidine kinase activity
KHQ32_RS00370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KHQ32_RS00375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KHQ32_RS00385	COG1078	dGTPase activity
KHQ32_RS00390	COG0561	phosphatase activity
KHQ32_RS00395	COG3343	RNA polymerase activity
KHQ32_RS00400	COG0504	CTP synthase activity
KHQ32_RS00405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KHQ32_RS00420	COG2337	Toxic component of a toxin-antitoxin (TA) module
KHQ32_RS00425	COG3973	AAA domain
KHQ32_RS00435	COG0248	Ppx GppA phosphatase
KHQ32_RS00460	COG0194	GDP metabolic process
KHQ32_RS00480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KHQ32_RS00485	COG0765	amino acid transport
KHQ32_RS00490	COG0765	amino acid transport
KHQ32_RS00495	COG4166	transmembrane transport
KHQ32_RS00500	COG4166	transmembrane transport
KHQ32_RS00505	COG0601	transmembrane transport
KHQ32_RS00510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KHQ32_RS00515	COG0444	Belongs to the ABC transporter superfamily
KHQ32_RS00520	COG4608	Belongs to the ABC transporter superfamily
KHQ32_RS00530	COG0359	binds to the 23S rRNA
KHQ32_RS00535	COG0305	Participates in initiation and elongation during chromosome replication
KHQ32_RS00540	COG2814	Major facilitator Superfamily
KHQ32_RS00555	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KHQ32_RS00565	COG0492	ferredoxin-NADP+ reductase activity
KHQ32_RS00570	COG0588	phosphoglycerate mutase activity
KHQ32_RS00575	COG1134	teichoic acid transport
KHQ32_RS00575	COG1388	LysM domain
KHQ32_RS00595	COG0586	Pfam SNARE associated Golgi protein
KHQ32_RS00610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KHQ32_RS00615	COG1077	Cell shape determining protein MreB Mrl
KHQ32_RS00625	COG0772	Belongs to the SEDS family
KHQ32_RS00630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KHQ32_RS00640	COG0561	phosphatase activity
KHQ32_RS00645	COG0577	efflux transmembrane transporter activity
KHQ32_RS00645	COG1136	(ABC) transporter
KHQ32_RS00655	COG2188	Transcriptional regulator
KHQ32_RS00660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KHQ32_RS00670	COG2252	PERMEase
KHQ32_RS00680	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KHQ32_RS00700	COG0561	phosphatase activity
KHQ32_RS00705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KHQ32_RS00710	COG4589	Belongs to the CDS family
KHQ32_RS00715	COG0750	zinc metalloprotease
KHQ32_RS00720	COG0442	prolyl-tRNA aminoacylation
KHQ32_RS00725	COG2176	DNA-directed DNA polymerase activity
KHQ32_RS00730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KHQ32_RS00755	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KHQ32_RS00780	COG2183	response to ionizing radiation
KHQ32_RS00790	COG2217	Heavy metal translocating P-type atpase
KHQ32_RS00920	COG3706	GGDEF domain
KHQ32_RS00925	COG0716	FMN binding
KHQ32_RS00930	COG2199	diguanylate cyclase activity
KHQ32_RS00955	COG1869	D-ribose catabolic process
KHQ32_RS00970	COG0668	transmembrane transport
KHQ32_RS00975	COG4975	Glucose uptake
KHQ32_RS00980	COG0166	Belongs to the GPI family
KHQ32_RS00985	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KHQ32_RS00990	COG1302	Protein conserved in bacteria
KHQ32_RS00995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KHQ32_RS01005	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KHQ32_RS01015	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KHQ32_RS01020	COG0049	tRNA binding
KHQ32_RS01025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KHQ32_RS01030	COG0673	inositol 2-dehydrogenase activity
KHQ32_RS01035	COG3842	ATPase activity
KHQ32_RS01045	COG1177	transmembrane transport
KHQ32_RS01050	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KHQ32_RS01055	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KHQ32_RS01060	COG1950	PFAM Membrane protein of
KHQ32_RS01065	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KHQ32_RS01070	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KHQ32_RS01080	COG0492	ferredoxin-NADP+ reductase activity
KHQ32_RS01100	COG0149	triose-phosphate isomerase activity
KHQ32_RS01115	COG0557	exoribonuclease II activity
KHQ32_RS01120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KHQ32_RS01125	COG0765	amino acid transport
KHQ32_RS01130	COG1126	abc transporter atp-binding protein
KHQ32_RS01135	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KHQ32_RS01140	COG0280	phosphate acetyltransferase
KHQ32_RS01145	COG0802	atpase or kinase
KHQ32_RS01160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KHQ32_RS01185	COG0540	Belongs to the ATCase OTCase family
KHQ32_RS01195	COG0505	Belongs to the CarA family
KHQ32_RS01205	COG0284	orotidine-5'-phosphate decarboxylase activity
KHQ32_RS01210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KHQ32_RS01215	COG0438	transferase activity, transferring glycosyl groups
KHQ32_RS01220	COG0438	transferase activity, transferring glycosyl groups
KHQ32_RS01230	COG1368	sulfuric ester hydrolase activity
KHQ32_RS01250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KHQ32_RS01250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KHQ32_RS01255	COG0025	NhaP-type Na H and K H
KHQ32_RS01260	COG0084	hydrolase, TatD family'
KHQ32_RS01265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KHQ32_RS01270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KHQ32_RS01275	COG1253	flavin adenine dinucleotide binding
KHQ32_RS01280	COG4466	Protein conserved in bacteria
KHQ32_RS01285	COG2131	deaminase
KHQ32_RS01295	COG1316	TRANSCRIPTIONal
KHQ32_RS01300	COG1983	PspC domain protein
KHQ32_RS01305	COG1968	undecaprenyl-diphosphatase activity
KHQ32_RS01325	COG0193	aminoacyl-tRNA hydrolase activity
KHQ32_RS01330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KHQ32_RS01335	COG2244	polysaccharide biosynthetic process
KHQ32_RS01340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KHQ32_RS01355	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KHQ32_RS01365	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KHQ32_RS01370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KHQ32_RS01480	COG1271	oxidase subunit
KHQ32_RS01485	COG1294	oxidase, subunit
KHQ32_RS01490	COG4988	ABC transporter
KHQ32_RS01495	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KHQ32_RS01500	COG1705	Flagellar rod assembly protein muramidase FlgJ
KHQ32_RS01530	COG0494	nUDIX hydrolase
KHQ32_RS01540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KHQ32_RS01550	COG1388	LysM domain
KHQ32_RS01560	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KHQ32_RS01565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KHQ32_RS01570	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KHQ32_RS01580	COG4120	Belongs to the binding-protein-dependent transport system permease family
KHQ32_RS01585	COG1116	anion transmembrane transporter activity
KHQ32_RS01605	COG2003	Belongs to the UPF0758 family
KHQ32_RS01610	COG1077	Cell shape determining protein MreB Mrl
KHQ32_RS01630	COG0765	amino acid transport
KHQ32_RS01645	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KHQ32_RS01670	COG0833	amino acid
KHQ32_RS01680	COG2264	protein methyltransferase activity
KHQ32_RS01685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KHQ32_RS01690	COG2001	Belongs to the MraZ family
KHQ32_RS01695	COG0275	rRNA processing
KHQ32_RS01705	COG0768	penicillin binding
KHQ32_RS01715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KHQ32_RS01720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KHQ32_RS01730	COG0849	cell division
KHQ32_RS01735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KHQ32_RS01740	COG1799	cell septum assembly
KHQ32_RS01745	COG0762	integral membrane protein
KHQ32_RS01750	COG2302	S4 RNA-binding domain
KHQ32_RS01755	COG3599	regulation of cell shape
KHQ32_RS01760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KHQ32_RS01775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KHQ32_RS01780	COG0217	transcriptional regulatory protein
KHQ32_RS01785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KHQ32_RS01790	COG1459	type II secretion system
KHQ32_RS01795	COG4537	Required for transformation and DNA binding
KHQ32_RS01825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KHQ32_RS01830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KHQ32_RS01835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KHQ32_RS01835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KHQ32_RS01845	COG0515	serine threonine protein kinase
KHQ32_RS01845	COG2815	serine threonine protein kinase
KHQ32_RS01850	COG1162	GTPase activity
KHQ32_RS01855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KHQ32_RS01865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KHQ32_RS01875	COG1461	Dihydroxyacetone kinase
KHQ32_RS01880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KHQ32_RS01885	COG0416	fatty acid biosynthetic process
KHQ32_RS01890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KHQ32_RS01895	COG0571	ribonuclease III activity
KHQ32_RS01900	COG1196	nuclear chromosome segregation
KHQ32_RS01905	COG0552	protein localization to endoplasmic reticulum
KHQ32_RS01910	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KHQ32_RS01915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KHQ32_RS01920	COG0228	four-way junction DNA binding
KHQ32_RS01925	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KHQ32_RS01930	COG0336	Belongs to the RNA methyltransferase TrmD family
KHQ32_RS01935	COG0335	large ribosomal subunit rRNA binding
KHQ32_RS01940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KHQ32_RS01945	COG1942	4-Oxalocrotonate Tautomerase
KHQ32_RS01950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KHQ32_RS01955	COG0494	nUDIX hydrolase
KHQ32_RS01960	COG1428	Deoxynucleoside kinase
KHQ32_RS01970	COG0561	phosphatase activity
KHQ32_RS01995	COG4862	establishment of competence for transformation
KHQ32_RS02015	COG0006	proline dipeptidase activity
KHQ32_RS02020	COG1609	Transcriptional regulator
KHQ32_RS02060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KHQ32_RS02065	COG3425	synthase
KHQ32_RS02075	COG0860	N-Acetylmuramoyl-L-alanine amidase
KHQ32_RS02080	COG0124	histidyl-tRNA synthetase
KHQ32_RS02085	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KHQ32_RS02090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KHQ32_RS02095	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KHQ32_RS02100	COG1610	YqeY-like protein
KHQ32_RS02105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KHQ32_RS02110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KHQ32_RS02115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KHQ32_RS02120	COG1381	Involved in DNA repair and RecF pathway recombination
KHQ32_RS02125	COG0752	glycyl-tRNA synthetase alpha subunit
KHQ32_RS02130	COG0751	glycine-tRNA ligase activity
KHQ32_RS02145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KHQ32_RS02150	COG1620	l-lactate permease
KHQ32_RS02165	COG2706	6-phosphogluconolactonase activity
KHQ32_RS02175	COG1674	ftsk spoiiie
KHQ32_RS02180	COG4152	abc transporter atp-binding protein
KHQ32_RS02185	COG1668	transmembrane transport
KHQ32_RS02190	COG0584	glycerophosphoryl diester phosphodiesterase
KHQ32_RS02195	COG0322	excinuclease ABC activity
KHQ32_RS02210	COG1739	Uncharacterized protein family UPF0029
KHQ32_RS02220	COG0516	GMP reductase activity
KHQ32_RS02220	COG0517	IMP dehydrogenase activity
KHQ32_RS02225	COG0632	four-way junction helicase activity
KHQ32_RS02230	COG2255	four-way junction helicase activity
KHQ32_RS02260	COG1862	Preprotein translocase
KHQ32_RS02265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KHQ32_RS02270	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KHQ32_RS02275	COG0513	Belongs to the DEAD box helicase family
KHQ32_RS02280	COG0110	maltose O-acetyltransferase activity
KHQ32_RS02285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KHQ32_RS02300	COG3906	Belongs to the UPF0473 family
KHQ32_RS02305	COG3906	Belongs to the UPF0473 family
KHQ32_RS02310	COG1555	photosystem II stabilization
KHQ32_RS02315	COG2333	competence protein COMEC
KHQ32_RS02315	COG0658	competence protein
KHQ32_RS02320	COG1466	dna polymerase III delta subunit
KHQ32_RS02325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KHQ32_RS02330	COG0268	Binds directly to 16S ribosomal RNA
KHQ32_RS02365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KHQ32_RS02380	COG1193	negative regulation of DNA recombination
KHQ32_RS02390	COG3118	belongs to the thioredoxin family
KHQ32_RS02395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KHQ32_RS02400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KHQ32_RS02410	COG2357	RelA SpoT domain protein
KHQ32_RS02415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KHQ32_RS02420	COG0564	pseudouridine synthase activity
KHQ32_RS02425	COG2239	Acts as a magnesium transporter
KHQ32_RS02430	COG0779	Required for maturation of 30S ribosomal subunits
KHQ32_RS02435	COG0195	Participates in both transcription termination and antitermination
KHQ32_RS02440	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KHQ32_RS02450	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KHQ32_RS02455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KHQ32_RS02460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KHQ32_RS02465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KHQ32_RS02475	COG0196	riboflavin kinase activity
KHQ32_RS02485	COG3142	Participates in the control of copper homeostasis
KHQ32_RS02490	COG1307	EDD domain protein, DegV family
KHQ32_RS02495	COG1307	EDD domain protein, DegV family
KHQ32_RS02500	COG0277	FAD linked oxidase domain protein
KHQ32_RS02505	COG4479	Belongs to the UPF0346 family
KHQ32_RS02510	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KHQ32_RS02515	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KHQ32_RS02535	COG0758	DNA mediated transformation
KHQ32_RS02540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KHQ32_RS02545	COG4974	Belongs to the 'phage' integrase family
KHQ32_RS02560	COG2814	Major facilitator Superfamily
KHQ32_RS02570	COG0187	DNA topoisomerase II activity
KHQ32_RS02575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KHQ32_RS02595	COG1227	inorganic diphosphatase activity
KHQ32_RS02605	COG3448	diguanylate cyclase activity
KHQ32_RS02605	COG4175	Glycine betaine
KHQ32_RS02630	COG1011	Hydrolase
KHQ32_RS02650	COG5503	Protein of unknown function (DUF1447)
KHQ32_RS02660	COG0242	peptide deformylase activity
KHQ32_RS02665	COG4476	Belongs to the UPF0223 family
KHQ32_RS02670	COG0483	inositol monophosphate 1-phosphatase activity
KHQ32_RS02675	COG1217	gtp-binding protein TYPA
KHQ32_RS02685	COG4471	UPF0298 protein
KHQ32_RS02690	COG0742	ribosomal rna small subunit methyltransferase
KHQ32_RS02695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KHQ32_RS02700	COG3480	Lon protease (S16) C-terminal proteolytic domain
KHQ32_RS02705	COG0477	Major facilitator Superfamily
KHQ32_RS02710	COG0358	DNA primase activity
KHQ32_RS02715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KHQ32_RS02725	COG0745	RESPONSE REGULATOR receiver
KHQ32_RS02730	COG5002	protein histidine kinase activity
KHQ32_RS02735	COG0572	uridine kinase
KHQ32_RS02740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KHQ32_RS02750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KHQ32_RS02755	COG0670	Belongs to the BI1 family
KHQ32_RS02775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KHQ32_RS02780	COG0237	dephospho-CoA kinase activity
KHQ32_RS02790	COG1484	DNA-dependent DNA replication
KHQ32_RS02805	COG0745	RESPONSE REGULATOR receiver
KHQ32_RS02810	COG5002	protein histidine kinase activity
KHQ32_RS02835	COG1686	Belongs to the peptidase S11 family
KHQ32_RS02840	COG0626	cystathionine gamma-synthase activity
KHQ32_RS02865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KHQ32_RS02875	COG0488	(ABC) transporter
KHQ32_RS02925	COG1304	FMN binding
KHQ32_RS02940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KHQ32_RS02955	COG4690	dipeptidase activity
KHQ32_RS02960	COG1266	CAAX protease self-immunity
KHQ32_RS03040	COG1216	Glycosyl transferase, family 2
KHQ32_RS03045	COG1272	protein, Hemolysin III
KHQ32_RS03050	COG1268	BioY protein
KHQ32_RS03065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KHQ32_RS03070	COG0439	Biotin carboxylase
KHQ32_RS03075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KHQ32_RS03085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KHQ32_RS03095	COG0604	alcohol dehydrogenase
KHQ32_RS03095	COG3321	synthase
KHQ32_RS03110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KHQ32_RS03120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KHQ32_RS03125	COG2755	lipolytic protein G-D-S-L family
KHQ32_RS03125	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KHQ32_RS03140	COG0446	pyridine nucleotide-disulphide oxidoreductase
KHQ32_RS03160	COG0352	thiamine-phosphate diphosphorylase activity
KHQ32_RS03165	COG0351	phosphomethylpyrimidine kinase
KHQ32_RS03170	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KHQ32_RS03175	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KHQ32_RS03185	COG0584	glycerophosphoryl diester phosphodiesterase
KHQ32_RS03200	COG0561	phosphatase activity
KHQ32_RS03220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KHQ32_RS03230	COG1131	(ABC) transporter
KHQ32_RS03235	COG0537	adenosine 5'-monophosphoramidase activity
KHQ32_RS03245	COG0556	nucleotide-excision repair
KHQ32_RS03260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KHQ32_RS03290	COG0116	Belongs to the methyltransferase superfamily
KHQ32_RS03300	COG3599	regulation of cell shape
KHQ32_RS03305	COG4474	Belongs to the UPF0398 family
KHQ32_RS03310	COG3331	DNA recombination
KHQ32_RS03330	COG3935	DnaD domain protein
KHQ32_RS03345	COG0017	Asparaginyl-tRNA synthetase
KHQ32_RS03355	COG1199	ATP-dependent helicase activity
KHQ32_RS03355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KHQ32_RS03360	COG2261	transglycosylase associated protein
KHQ32_RS03435	COG1304	FMN binding
KHQ32_RS03440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KHQ32_RS03445	COG0706	membrane insertase activity
KHQ32_RS03455	COG0105	UTP biosynthetic process
KHQ32_RS03465	COG0531	amino acid
KHQ32_RS03475	COG2855	membrane
KHQ32_RS03485	COG1215	transferase activity, transferring glycosyl groups
KHQ32_RS03495	COG0183	Belongs to the thiolase family
KHQ32_RS03505	COG0735	belongs to the Fur family
KHQ32_RS03515	COG0390	transport system, permease component
KHQ32_RS03520	COG4619	ABC transporter
KHQ32_RS03525	COG2267	carboxylic ester hydrolase activity
KHQ32_RS03530	COG2390	Transcriptional regulator
KHQ32_RS03540	COG1136	(ABC) transporter
KHQ32_RS03570	COG0095	Lipoate-protein ligase
KHQ32_RS03575	COG0366	Alpha amylase catalytic
KHQ32_RS03595	COG0741	lytic transglycosylase activity
KHQ32_RS03605	COG1694	Mazg nucleotide pyrophosphohydrolase
KHQ32_RS03610	COG1611	Belongs to the LOG family
KHQ32_RS03625	COG1609	Transcriptional regulator
KHQ32_RS03635	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KHQ32_RS03640	COG0151	Belongs to the GarS family
KHQ32_RS03645	COG0138	bifunctional purine biosynthesis protein purh
KHQ32_RS03650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KHQ32_RS03655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KHQ32_RS03665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KHQ32_RS03670	COG0047	phosphoribosylformylglycinamidine synthase activity
KHQ32_RS03675	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KHQ32_RS03680	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KHQ32_RS03685	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KHQ32_RS03690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KHQ32_RS03695	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KHQ32_RS03700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KHQ32_RS03705	COG1696	Membrane protein involved in D-alanine export
KHQ32_RS03725	COG0481	GTPase activity
KHQ32_RS03745	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KHQ32_RS03750	COG3475	LICD family
KHQ32_RS03775	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KHQ32_RS03780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KHQ32_RS03795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KHQ32_RS03800	COG2195	Cleaves the N-terminal amino acid of tripeptides
KHQ32_RS03805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KHQ32_RS03810	COG2384	SAM-dependent methyltransferase
KHQ32_RS03815	COG0457	Tetratricopeptide repeat
KHQ32_RS03845	COG2807	transmembrane transport
KHQ32_RS03850	COG4720	Psort location CytoplasmicMembrane, score
KHQ32_RS03855	COG0351	phosphomethylpyrimidine kinase
KHQ32_RS03865	COG1160	GTP binding
KHQ32_RS03870	COG0539	negative regulation of cytoplasmic translation
KHQ32_RS03875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KHQ32_RS03885	COG0514	ATP-dependent DNA helicase (RecQ)
KHQ32_RS03895	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KHQ32_RS03900	COG1187	pseudouridine synthase activity
KHQ32_RS03905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KHQ32_RS03910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KHQ32_RS03915	COG0456	acetyltransferase
KHQ32_RS03925	COG2996	Protein conserved in bacteria
KHQ32_RS03935	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KHQ32_RS03940	COG0149	triose-phosphate isomerase activity
KHQ32_RS03945	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KHQ32_RS03955	COG3835	regulator
KHQ32_RS03960	COG0475	glutathione-regulated potassium exporter activity
KHQ32_RS03970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KHQ32_RS03975	COG0587	DNA-directed DNA polymerase activity
KHQ32_RS03990	COG0488	(ABC) transporter
KHQ32_RS03995	COG0617	tRNA 3'-terminal CCA addition
KHQ32_RS04010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KHQ32_RS04025	COG1316	TRANSCRIPTIONal
KHQ32_RS04040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KHQ32_RS04135	COG2369	cell adhesion
KHQ32_RS04145	COG1783	phage Terminase large subunit
KHQ32_RS04315	COG0052	Belongs to the universal ribosomal protein uS2 family
KHQ32_RS04320	COG2827	Endonuclease containing a URI domain
KHQ32_RS04325	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KHQ32_RS04330	COG0204	Acyl-transferase
KHQ32_RS04335	COG3763	UPF0154 protein
KHQ32_RS04340	COG4224	UPF0291 protein
KHQ32_RS04345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KHQ32_RS04350	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KHQ32_RS04350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KHQ32_RS04355	COG1234	tRNA 3'-trailer cleavage
KHQ32_RS04370	COG0484	heat shock protein binding
KHQ32_RS04375	COG0443	Heat shock 70 kDa protein
KHQ32_RS04380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KHQ32_RS04385	COG1420	regulation of RNA biosynthetic process
KHQ32_RS04400	COG0463	Glycosyl transferase, family 2
KHQ32_RS04415	COG0024	Methionine aminopeptidase
KHQ32_RS04425	COG1682	transport, permease protein
KHQ32_RS04430	COG1134	teichoic acid transport
KHQ32_RS04430	COG1388	LysM domain
KHQ32_RS04440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KHQ32_RS04445	COG2309	aminopeptidase activity
KHQ32_RS04450	COG1278	Cold shock
KHQ32_RS04460	COG2814	Major facilitator Superfamily
KHQ32_RS04465	COG1388	LysM domain
KHQ32_RS04470	COG1072	(Pantothenic acid kinase))
KHQ32_RS04475	COG3973	AAA domain
KHQ32_RS04480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KHQ32_RS04485	COG1058	Belongs to the CinA family
KHQ32_RS04485	COG1546	Belongs to the CinA family
KHQ32_RS04490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KHQ32_RS04495	COG1426	Protein conserved in bacteria
KHQ32_RS04505	COG0612	Peptidase, M16
KHQ32_RS04510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KHQ32_RS04530	COG1070	Carbohydrate kinase
KHQ32_RS04535	COG3481	metal-dependent phosphohydrolase, HD sub domain
KHQ32_RS04540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KHQ32_RS04545	COG0420	3'-5' exonuclease activity
KHQ32_RS04555	COG3679	Belongs to the UPF0342 family
KHQ32_RS04560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KHQ32_RS04565	COG1438	arginine binding
KHQ32_RS04570	COG0018	arginyl-trna synthetase
KHQ32_RS04585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KHQ32_RS04595	COG1597	lipid kinase activity
KHQ32_RS04600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KHQ32_RS04610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KHQ32_RS04615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KHQ32_RS04615	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KHQ32_RS04635	COG0667	Aldo Keto reductase
KHQ32_RS04640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KHQ32_RS04645	COG0167	dihydroorotate dehydrogenase activity
KHQ32_RS04650	COG3859	Proton-coupled thiamine transporter YuaJ
KHQ32_RS04660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KHQ32_RS04665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KHQ32_RS04670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KHQ32_RS04675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KHQ32_RS04680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KHQ32_RS04685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KHQ32_RS04705	COG4684	Psort location CytoplasmicMembrane, score
KHQ32_RS04710	COG0436	Aminotransferase
KHQ32_RS04720	COG0436	Aminotransferase
KHQ32_RS04730	COG1609	Transcriptional regulator
KHQ32_RS04755	COG1321	iron dependent repressor
KHQ32_RS04755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KHQ32_RS04765	COG3764	Sortase (surface protein transpeptidase)
KHQ32_RS04770	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KHQ32_RS04775	COG0513	Belongs to the DEAD box helicase family
KHQ32_RS04780	COG0673	inositol 2-dehydrogenase activity
KHQ32_RS04785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KHQ32_RS04790	COG0501	Belongs to the peptidase M48B family
KHQ32_RS04795	COG1704	LemA family
KHQ32_RS04810	COG2153	protein acetylation
KHQ32_RS04830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KHQ32_RS04835	COG0562	UDP-galactopyranose mutase
KHQ32_RS04840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KHQ32_RS04845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KHQ32_RS04855	COG0505	Belongs to the CarA family
KHQ32_RS04865	COG0564	pseudouridine synthase activity
KHQ32_RS04875	COG1757	Na H antiporter
KHQ32_RS04880	COG1113	amino acid transport
KHQ32_RS04895	COG0126	phosphoglycerate kinase activity
KHQ32_RS04925	COG0737	Belongs to the 5'-nucleotidase family
KHQ32_RS04970	COG3716	PTS system mannose fructose sorbose family IID component
KHQ32_RS04975	COG3715	PTS system
KHQ32_RS05045	COG1185	polyribonucleotide nucleotidyltransferase activity
KHQ32_RS05055	COG0586	Pfam SNARE associated Golgi protein
KHQ32_RS05060	COG1758	RNA polymerase activity
KHQ32_RS05065	COG0194	GDP metabolic process
KHQ32_RS05070	COG0497	DNA recombination
KHQ32_RS05075	COG1438	arginine binding
KHQ32_RS05080	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KHQ32_RS05090	COG1722	exodeoxyribonuclease VII activity
KHQ32_RS05095	COG1570	exodeoxyribonuclease VII activity
KHQ32_RS05100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KHQ32_RS05105	COG4720	Psort location CytoplasmicMembrane, score
KHQ32_RS05120	COG0363	glucosamine-6-phosphate deaminase activity
KHQ32_RS05125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KHQ32_RS05140	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KHQ32_RS05150	COG1323	Belongs to the UPF0348 family
KHQ32_RS05160	COG0799	negative regulation of ribosome biogenesis
KHQ32_RS05165	COG1713	HD superfamily hydrolase involved in NAD metabolism
KHQ32_RS05170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KHQ32_RS05180	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KHQ32_RS05185	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KHQ32_RS05190	COG1181	Belongs to the D-alanine--D-alanine ligase family
KHQ32_RS05205	COG0531	amino acid
KHQ32_RS05210	COG0459	protein refolding
KHQ32_RS05215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KHQ32_RS05220	COG0488	(ABC) transporter
KHQ32_RS05225	COG0285	dihydrofolate synthase activity
KHQ32_RS05230	COG0525	valine-tRNA ligase activity
KHQ32_RS05235	COG1279	arginine transmembrane transporter activity
KHQ32_RS05240	COG0589	response to stress
KHQ32_RS05255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KHQ32_RS05280	COG3557	Belongs to the UPF0374 family
KHQ32_RS05285	COG2137	regulation of response to DNA damage stimulus
KHQ32_RS05295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KHQ32_RS05305	COG0581	inorganic phosphate transmembrane transporter activity
KHQ32_RS05310	COG0573	inorganic phosphate transmembrane transporter activity
KHQ32_RS05335	COG0393	Putative heavy-metal-binding
KHQ32_RS05340	COG0647	UMP catabolic process
KHQ32_RS05345	COG4470	Protein conserved in bacteria
KHQ32_RS05350	COG0737	Belongs to the 5'-nucleotidase family
KHQ32_RS05360	COG0006	proline dipeptidase activity
KHQ32_RS05380	COG0596	Alpha beta hydrolase
KHQ32_RS05385	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KHQ32_RS05390	COG1169	isochorismate synthase
KHQ32_RS05410	COG0531	amino acid
KHQ32_RS05420	COG2814	Major facilitator Superfamily
KHQ32_RS05430	COG1063	alcohol dehydrogenase
KHQ32_RS05435	COG0813	purine-nucleoside phosphorylase activity
KHQ32_RS05440	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KHQ32_RS05450	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KHQ32_RS05460	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KHQ32_RS05465	COG1447	Phosphotransferase system cellobiose-specific component IIA
KHQ32_RS05470	COG1120	ATPase activity
KHQ32_RS05500	COG1686	Belongs to the peptidase S11 family
KHQ32_RS05505	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KHQ32_RS05510	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KHQ32_RS05515	COG2271	Major facilitator Superfamily
KHQ32_RS05545	COG0174	glutamine synthetase
KHQ32_RS05550	COG0789	Transcriptional regulator
KHQ32_RS05555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KHQ32_RS05570	COG1940	carbohydrate kinase activity
KHQ32_RS05585	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KHQ32_RS05590	COG0768	penicillin binding
KHQ32_RS05600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KHQ32_RS05605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KHQ32_RS05610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KHQ32_RS05610	COG0072	phenylalanine-tRNA ligase activity
KHQ32_RS05615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KHQ32_RS05620	COG1733	regulation of RNA biosynthetic process
KHQ32_RS05630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KHQ32_RS05650	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KHQ32_RS05655	COG0653	protein targeting
KHQ32_RS05670	COG0756	dUTP diphosphatase activity
KHQ32_RS05680	COG0791	NLP P60 protein
KHQ32_RS05690	COG0542	response to heat
KHQ32_RS05695	COG0604	alcohol dehydrogenase
KHQ32_RS05700	COG0028	Belongs to the TPP enzyme family
KHQ32_RS05705	COG3527	Alpha-acetolactate decarboxylase
KHQ32_RS05735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KHQ32_RS05750	COG0740	serine-type endopeptidase activity
KHQ32_RS05760	COG1481	regulation of sporulation
KHQ32_RS05765	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KHQ32_RS05770	COG1660	Displays ATPase and GTPase activities
KHQ32_RS05775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KHQ32_RS05815	COG0101	tRNA pseudouridine synthase activity
KHQ32_RS05825	COG1122	ATPase activity
KHQ32_RS05830	COG1122	ATPase activity
KHQ32_RS05835	COG3594	Acyltransferase
KHQ32_RS05850	COG0803	Belongs to the bacterial solute-binding protein 9 family
KHQ32_RS05855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KHQ32_RS05860	COG1121	(ABC) transporter
KHQ32_RS05875	COG0222	ribosome binding
KHQ32_RS05880	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KHQ32_RS05885	COG0081	regulation of translation
KHQ32_RS05890	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KHQ32_RS05895	COG0250	Participates in transcription elongation, termination and antitermination
KHQ32_RS05900	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KHQ32_RS05915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KHQ32_RS05920	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KHQ32_RS05925	COG0215	cysteine-tRNA ligase activity
KHQ32_RS05940	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KHQ32_RS05950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KHQ32_RS05960	COG0203	ribosomal protein L17
KHQ32_RS05965	COG0202	RNA polymerase activity
KHQ32_RS05970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KHQ32_RS05975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KHQ32_RS05980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KHQ32_RS05985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KHQ32_RS06000	COG0200	Binds to the 23S rRNA
KHQ32_RS06005	COG1841	ribosomal large subunit assembly
KHQ32_RS06010	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KHQ32_RS06015	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KHQ32_RS06020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KHQ32_RS06025	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KHQ32_RS06030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KHQ32_RS06035	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KHQ32_RS06040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KHQ32_RS06050	COG0255	Belongs to the universal ribosomal protein uL29 family
KHQ32_RS06055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KHQ32_RS06060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KHQ32_RS06065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KHQ32_RS06070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KHQ32_RS06075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KHQ32_RS06080	COG0089	rRNA binding
KHQ32_RS06090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KHQ32_RS06095	COG0051	transcription antitermination factor activity, RNA binding
KHQ32_RS06120	COG1214	PFAM Peptidase M22, glycoprotease
KHQ32_RS06125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KHQ32_RS06145	COG3870	Protein conserved in bacteria
KHQ32_RS06150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KHQ32_RS06160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KHQ32_RS06165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KHQ32_RS06170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KHQ32_RS06185	COG2813	Specifically methylates the guanine in position
KHQ32_RS06225	COG1979	alcohol dehydrogenase
KHQ32_RS06230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KHQ32_RS06235	COG0085	RNA polymerase activity
KHQ32_RS06240	COG0542	response to heat
KHQ32_RS06245	COG4463	regulation of RNA biosynthetic process
KHQ32_RS06265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KHQ32_RS06270	COG1428	Deoxynucleoside kinase
KHQ32_RS06280	COG1686	Belongs to the peptidase S11 family
KHQ32_RS06285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KHQ32_RS06290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KHQ32_RS06295	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KHQ32_RS06300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KHQ32_RS06305	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KHQ32_RS06310	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KHQ32_RS06315	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KHQ32_RS06320	COG0356	it plays a direct role in the translocation of protons across the membrane
KHQ32_RS06325	COG2233	PERMEase
KHQ32_RS06335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KHQ32_RS06340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KHQ32_RS06345	COG0009	L-threonylcarbamoyladenylate synthase
KHQ32_RS06350	COG2890	protein-(glutamine-N5) methyltransferase activity
KHQ32_RS06355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KHQ32_RS06360	COG1435	thymidine kinase activity
KHQ32_RS06365	COG3442	glutamine amidotransferase
KHQ32_RS06370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KHQ32_RS06375	COG1482	cell wall glycoprotein biosynthetic process
KHQ32_RS06395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KHQ32_RS06420	COG1132	(ABC) transporter
KHQ32_RS06425	COG1132	(ABC) transporter
KHQ32_RS06430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KHQ32_RS06435	COG0588	phosphoglycerate mutase activity
KHQ32_RS06450	COG1573	uracil-dna glycosylase
KHQ32_RS06455	COG2610	gluconate transmembrane transporter activity
KHQ32_RS06460	COG0708	Exodeoxyribonuclease III
KHQ32_RS06465	COG1012	belongs to the aldehyde dehydrogenase family
KHQ32_RS06465	COG1454	alcohol dehydrogenase
KHQ32_RS06470	COG2235	arginine
KHQ32_RS06475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KHQ32_RS06480	COG0531	amino acid
KHQ32_RS06490	COG3590	peptidase
KHQ32_RS06505	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
KHQ32_RS06510	COG2188	Transcriptional regulator
KHQ32_RS06515	COG1418	mRNA catabolic process
KHQ32_RS06540	COG0488	(ABC) transporter
KHQ32_RS06550	COG1121	(ABC) transporter
KHQ32_RS06560	COG1846	Transcriptional regulator
KHQ32_RS06565	COG3091	SprT-like family
KHQ32_RS06605	COG3104	oligopeptide transport
KHQ32_RS06615	COG5002	protein histidine kinase activity
KHQ32_RS06620	COG0745	RESPONSE REGULATOR receiver
KHQ32_RS06630	COG0012	GTP binding
KHQ32_RS06635	COG4481	Protein conserved in bacteria
KHQ32_RS06640	COG1475	DNA binding
KHQ32_RS06645	COG1192	Involved in chromosome partitioning
KHQ32_RS06650	COG0357	Ribosomal RNA small subunit methyltransferase G
KHQ32_RS06655	COG1194	a g-specific adenine glycosylase
KHQ32_RS06660	COG5002	protein histidine kinase activity
KHQ32_RS06665	COG0745	RESPONSE REGULATOR receiver
KHQ32_RS06670	COG0318	PFAM AMP-dependent synthetase and ligase
KHQ32_RS06675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KHQ32_RS06685	COG1335	isochorismatase
KHQ32_RS06695	COG4443	Transcriptional Coactivator p15 (PC4)
KHQ32_RS06700	COG0252	asparaginase activity
KHQ32_RS06705	COG0531	amino acid
KHQ32_RS06715	COG2130	NADP-dependent
KHQ32_RS06725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KHQ32_RS06760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KHQ32_RS06775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KHQ32_RS06780	COG1554	hydrolase, family 65, central catalytic
KHQ32_RS06785	COG1263	PTS System
KHQ32_RS06785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KHQ32_RS06785	COG2190	(PTS) system
KHQ32_RS06790	COG1263	PTS System
KHQ32_RS06790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KHQ32_RS06790	COG2190	(PTS) system
KHQ32_RS06795	COG2188	Transcriptional regulator
KHQ32_RS06805	COG1511	domain protein
KHQ32_RS06810	COG1959	2 iron, 2 sulfur cluster binding
KHQ32_RS06820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KHQ32_RS06825	COG3620	sequence-specific DNA binding
KHQ32_RS06845	COG0657	acetylesterase activity
KHQ32_RS06850	COG1113	amino acid transport
KHQ32_RS06855	COG0628	permease
KHQ32_RS06865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KHQ32_RS06870	COG0765	amino acid transport
KHQ32_RS06875	COG1126	abc transporter atp-binding protein
KHQ32_RS06885	COG0640	Transcriptional regulator
KHQ32_RS06890	COG2217	Heavy metal translocating P-type atpase
KHQ32_RS06895	COG1309	transcriptional regulator
KHQ32_RS06900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KHQ32_RS06905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KHQ32_RS06920	COG0028	Belongs to the TPP enzyme family
KHQ32_RS06930	COG4221	oxidoreductase activity
KHQ32_RS06935	COG0346	lactoylglutathione lyase activity
KHQ32_RS06940	COG0656	L-ascorbic acid biosynthetic process
KHQ32_RS06945	COG1733	regulation of RNA biosynthetic process
KHQ32_RS06950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KHQ32_RS06965	COG0328	RNA-DNA hybrid ribonuclease activity
KHQ32_RS06970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KHQ32_RS06975	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KHQ32_RS06980	COG1113	amino acid transport
KHQ32_RS06985	COG0569	domain protein
KHQ32_RS06995	COG0706	membrane insertase activity
KHQ32_RS07000	COG0594	ribonuclease P activity
KHQ32_RS07025	COG0772	Belongs to the SEDS family