locus-tag	class	description
IE337_RS00005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IE337_RS00010	COG2501	S4 domain
IE337_RS00015	COG0592	DNA-directed DNA polymerase activity
IE337_RS00020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IE337_RS00025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IE337_RS00030	COG0594	ribonuclease P activity
IE337_RS00035	COG0706	membrane insertase activity
IE337_RS00045	COG1120	ATPase activity
IE337_RS00070	COG0569	domain protein
IE337_RS00075	COG1113	amino acid transport
IE337_RS00085	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IE337_RS00090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IE337_RS00095	COG0328	RNA-DNA hybrid ribonuclease activity
IE337_RS00110	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IE337_RS00115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IE337_RS00125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IE337_RS00130	COG0741	lytic transglycosylase activity
IE337_RS00135	COG3878	Protein conserved in bacteria
IE337_RS00140	COG3878	Protein conserved in bacteria
IE337_RS00150	COG1827	regulation of RNA biosynthetic process
IE337_RS00155	COG0477	Major facilitator Superfamily
IE337_RS00160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IE337_RS00160	COG4499	WXG100 protein secretion system (Wss), protein YukC
IE337_RS00165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IE337_RS00170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IE337_RS00175	COG1250	3-hydroxyacyl-CoA dehydrogenase
IE337_RS00190	COG2217	Heavy metal translocating P-type atpase
IE337_RS00195	COG0640	Transcriptional regulator
IE337_RS00200	COG1126	abc transporter atp-binding protein
IE337_RS00205	COG0765	amino acid transport
IE337_RS00210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE337_RS00220	COG0628	permease
IE337_RS00225	COG1113	amino acid transport
IE337_RS00245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IE337_RS00255	COG0531	amino acid
IE337_RS00265	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IE337_RS00275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IE337_RS00285	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IE337_RS00295	COG0531	amino acid
IE337_RS00300	COG0531	amino acid
IE337_RS00305	COG0252	asparaginase activity
IE337_RS00310	COG4443	Transcriptional Coactivator p15 (PC4)
IE337_RS00320	COG1335	isochorismatase
IE337_RS00340	COG0745	RESPONSE REGULATOR receiver
IE337_RS00345	COG5002	protein histidine kinase activity
IE337_RS00350	COG1194	a g-specific adenine glycosylase
IE337_RS00355	COG0357	Ribosomal RNA small subunit methyltransferase G
IE337_RS00360	COG1192	Involved in chromosome partitioning
IE337_RS00365	COG1475	DNA binding
IE337_RS00370	COG4481	Protein conserved in bacteria
IE337_RS00375	COG0012	GTP binding
IE337_RS00385	COG0745	RESPONSE REGULATOR receiver
IE337_RS00390	COG5002	protein histidine kinase activity
IE337_RS00400	COG3104	oligopeptide transport
IE337_RS00425	COG2814	Major facilitator Superfamily
IE337_RS00450	COG3091	SprT-like family
IE337_RS00455	COG1846	Transcriptional regulator
IE337_RS00465	COG1121	(ABC) transporter
IE337_RS00475	COG0488	(ABC) transporter
IE337_RS00490	COG1418	mRNA catabolic process
IE337_RS00495	COG2188	Transcriptional regulator
IE337_RS00500	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IE337_RS00515	COG3590	peptidase
IE337_RS00520	COG1012	belongs to the aldehyde dehydrogenase family
IE337_RS00520	COG1454	alcohol dehydrogenase
IE337_RS00525	COG0708	Exodeoxyribonuclease III
IE337_RS00545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IE337_RS00550	COG1132	(ABC) transporter
IE337_RS00555	COG1132	(ABC) transporter
IE337_RS00585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IE337_RS00620	COG1482	cell wall glycoprotein biosynthetic process
IE337_RS00625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IE337_RS00630	COG3442	glutamine amidotransferase
IE337_RS00640	COG1435	thymidine kinase activity
IE337_RS00645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IE337_RS00650	COG2890	protein-(glutamine-N5) methyltransferase activity
IE337_RS00655	COG0009	L-threonylcarbamoyladenylate synthase
IE337_RS00660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IE337_RS00665	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IE337_RS00675	COG2233	PERMEase
IE337_RS00680	COG0356	it plays a direct role in the translocation of protons across the membrane
IE337_RS00685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IE337_RS00690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IE337_RS00695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IE337_RS00710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IE337_RS00715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IE337_RS00720	COG1428	Deoxynucleoside kinase
IE337_RS00725	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IE337_RS00750	COG4463	regulation of RNA biosynthetic process
IE337_RS00755	COG0542	response to heat
IE337_RS00760	COG0085	RNA polymerase activity
IE337_RS00765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IE337_RS00770	COG1979	alcohol dehydrogenase
IE337_RS00805	COG1073	alpha beta
IE337_RS00810	COG2813	Specifically methylates the guanine in position
IE337_RS00815	COG0590	tRNA wobble adenosine to inosine editing
IE337_RS00825	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IE337_RS00830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IE337_RS00835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IE337_RS00845	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IE337_RS00850	COG3870	Protein conserved in bacteria
IE337_RS00870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IE337_RS00875	COG1214	PFAM Peptidase M22, glycoprotease
IE337_RS00890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IE337_RS00905	COG0051	transcription antitermination factor activity, RNA binding
IE337_RS00910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IE337_RS00920	COG0089	rRNA binding
IE337_RS00925	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IE337_RS00930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IE337_RS00935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IE337_RS00940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IE337_RS00945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IE337_RS00950	COG0255	Belongs to the universal ribosomal protein uL29 family
IE337_RS00960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IE337_RS00965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IE337_RS00970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IE337_RS00975	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IE337_RS00980	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IE337_RS00985	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IE337_RS00990	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IE337_RS00995	COG1841	ribosomal large subunit assembly
IE337_RS01000	COG0200	Binds to the 23S rRNA
IE337_RS01010	COG0563	adenylate kinase activity
IE337_RS01015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IE337_RS01020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IE337_RS01030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IE337_RS01035	COG0202	RNA polymerase activity
IE337_RS01040	COG0203	ribosomal protein L17
IE337_RS01050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IE337_RS01060	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IE337_RS01075	COG0215	cysteine-tRNA ligase activity
IE337_RS01080	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IE337_RS01085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IE337_RS01095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IE337_RS01105	COG0250	Participates in transcription elongation, termination and antitermination
IE337_RS01110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IE337_RS01115	COG0081	regulation of translation
IE337_RS01120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IE337_RS01125	COG0222	ribosome binding
IE337_RS01130	COG1121	(ABC) transporter
IE337_RS01135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE337_RS01140	COG0803	Belongs to the bacterial solute-binding protein 9 family
IE337_RS01160	COG1122	ATPase activity
IE337_RS01165	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IE337_RS01170	COG0101	tRNA pseudouridine synthase activity
IE337_RS01175	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IE337_RS01240	COG0656	L-ascorbic acid biosynthetic process
IE337_RS01245	COG0477	Major facilitator Superfamily
IE337_RS01260	COG0583	DNA-binding transcription factor activity
IE337_RS01265	COG2855	membrane
IE337_RS01270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE337_RS01285	COG1388	LysM domain
IE337_RS01285	COG3942	CHAP domain
IE337_RS01295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IE337_RS01310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IE337_RS01315	COG1481	regulation of sporulation
IE337_RS01320	COG0740	serine-type endopeptidase activity
IE337_RS01330	COG0653	protein targeting
IE337_RS01345	COG1073	alpha beta
IE337_RS01395	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IE337_RS01405	COG1846	Transcriptional regulator
IE337_RS01415	COG0039	L-malate dehydrogenase activity
IE337_RS01420	COG3527	Alpha-acetolactate decarboxylase
IE337_RS01425	COG0028	Belongs to the TPP enzyme family
IE337_RS01430	COG0542	response to heat
IE337_RS01435	COG1388	LysM domain
IE337_RS01435	COG3942	CHAP domain
IE337_RS01450	COG0756	dUTP diphosphatase activity
IE337_RS01455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IE337_RS01460	COG4956	integral membrane protein (PIN domain superfamily)
IE337_RS01470	COG0653	protein targeting
IE337_RS01475	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IE337_RS01490	COG0584	glycerophosphoryl diester phosphodiesterase
IE337_RS01500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IE337_RS01515	COG1733	regulation of RNA biosynthetic process
IE337_RS01520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IE337_RS01525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IE337_RS01525	COG0072	phenylalanine-tRNA ligase activity
IE337_RS01530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IE337_RS01535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IE337_RS01545	COG0768	penicillin binding
IE337_RS01550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IE337_RS01565	COG1940	carbohydrate kinase activity
IE337_RS01580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IE337_RS01585	COG0789	Transcriptional regulator
IE337_RS01590	COG0174	glutamine synthetase
IE337_RS01630	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IE337_RS01635	COG1687	branched-chain amino acid
IE337_RS01670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IE337_RS01670	COG1215	transferase activity, transferring glycosyl groups
IE337_RS01675	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IE337_RS01680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IE337_RS01715	COG0789	Transcriptional regulator
IE337_RS01735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IE337_RS01740	COG1609	Transcriptional regulator
IE337_RS01750	COG0366	Alpha amylase catalytic
IE337_RS01780	COG1131	(ABC) transporter
IE337_RS01800	COG2249	NAD(P)H dehydrogenase (quinone) activity
IE337_RS01825	COG0586	Pfam SNARE associated Golgi protein
IE337_RS01830	COG1114	Component of the transport system for branched-chain amino acids
IE337_RS01835	COG0446	pyridine nucleotide-disulphide oxidoreductase
IE337_RS01840	COG2188	Transcriptional regulator
IE337_RS01845	COG2190	(PTS) system
IE337_RS01850	COG2190	(PTS) system
IE337_RS01850	COG1263	PTS System
IE337_RS01850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE337_RS01855	COG1554	hydrolase, family 65, central catalytic
IE337_RS01865	COG3706	GGDEF domain
IE337_RS01885	COG0702	epimerase
IE337_RS01900	COG1250	3-hydroxyacyl-CoA dehydrogenase
IE337_RS01910	COG0586	Pfam SNARE associated Golgi protein
IE337_RS01920	COG1272	protein, Hemolysin III
IE337_RS01995	COG2966	Psort location CytoplasmicMembrane, score
IE337_RS02010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IE337_RS02015	COG1063	alcohol dehydrogenase
IE337_RS02035	COG0454	-acetyltransferase
IE337_RS02035	COG0456	acetyltransferase
IE337_RS02045	COG1914	H( )-stimulated, divalent metal cation uptake system
IE337_RS02075	COG1309	transcriptional regulator
IE337_RS02085	COG4690	dipeptidase activity
IE337_RS02095	COG0004	ammonium transporteR
IE337_RS02110	COG0105	UTP biosynthetic process
IE337_RS02115	COG0071	Belongs to the small heat shock protein (HSP20) family
IE337_RS02125	COG1169	isochorismate synthase
IE337_RS02130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IE337_RS02135	COG0596	Alpha beta hydrolase
IE337_RS02155	COG4948	Mandelate Racemase Muconate Lactonizing
IE337_RS02160	COG0006	proline dipeptidase activity
IE337_RS02170	COG0737	Belongs to the 5'-nucleotidase family
IE337_RS02180	COG0647	UMP catabolic process
IE337_RS02195	COG0573	inorganic phosphate transmembrane transporter activity
IE337_RS02200	COG0581	inorganic phosphate transmembrane transporter activity
IE337_RS02210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IE337_RS02215	COG0704	Plays a role in the regulation of phosphate uptake
IE337_RS02220	COG2137	regulation of response to DNA damage stimulus
IE337_RS02225	COG3557	Belongs to the UPF0374 family
IE337_RS02235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IE337_RS02250	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IE337_RS02260	COG0589	response to stress
IE337_RS02270	COG1279	arginine transmembrane transporter activity
IE337_RS02275	COG0525	valine-tRNA ligase activity
IE337_RS02285	COG0488	(ABC) transporter
IE337_RS02290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IE337_RS02295	COG0459	protein refolding
IE337_RS02300	COG0531	amino acid
IE337_RS02310	COG1181	Belongs to the D-alanine--D-alanine ligase family
IE337_RS02320	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IE337_RS02330	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IE337_RS02335	COG1713	HD superfamily hydrolase involved in NAD metabolism
IE337_RS02340	COG0799	negative regulation of ribosome biogenesis
IE337_RS02345	COG2226	methyltransferase
IE337_RS02350	COG1323	Belongs to the UPF0348 family
IE337_RS02360	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IE337_RS02365	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IE337_RS02370	COG0716	FMN binding
IE337_RS02375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IE337_RS02380	COG0363	glucosamine-6-phosphate deaminase activity
IE337_RS02390	COG4720	Psort location CytoplasmicMembrane, score
IE337_RS02395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IE337_RS02400	COG1570	exodeoxyribonuclease VII activity
IE337_RS02405	COG1722	exodeoxyribonuclease VII activity
IE337_RS02415	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IE337_RS02420	COG1438	arginine binding
IE337_RS02425	COG0497	DNA recombination
IE337_RS02430	COG0194	GDP metabolic process
IE337_RS02435	COG1758	RNA polymerase activity
IE337_RS02440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IE337_RS02445	COG1098	S1 RNA binding domain
IE337_RS02555	COG1271	oxidase subunit
IE337_RS02560	COG1294	oxidase, subunit
IE337_RS02565	COG4988	ABC transporter
IE337_RS02570	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IE337_RS02575	COG1705	Flagellar rod assembly protein muramidase FlgJ
IE337_RS02580	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IE337_RS02595	COG1278	Cold shock
IE337_RS02600	COG0494	nUDIX hydrolase
IE337_RS02610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IE337_RS02625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IE337_RS02630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IE337_RS02645	COG4120	Belongs to the binding-protein-dependent transport system permease family
IE337_RS02650	COG1116	anion transmembrane transporter activity
IE337_RS02655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IE337_RS02660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IE337_RS02670	COG2003	Belongs to the UPF0758 family
IE337_RS02675	COG1077	Cell shape determining protein MreB Mrl
IE337_RS02680	COG1792	Involved in formation and maintenance of cell shape
IE337_RS02700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IE337_RS02710	COG0765	amino acid transport
IE337_RS02715	COG1126	abc transporter atp-binding protein
IE337_RS02720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE337_RS02735	COG0730	response to heat
IE337_RS02745	COG0833	amino acid
IE337_RS02755	COG2264	protein methyltransferase activity
IE337_RS02760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IE337_RS02770	COG2001	Belongs to the MraZ family
IE337_RS02775	COG0275	rRNA processing
IE337_RS02785	COG0768	penicillin binding
IE337_RS02795	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IE337_RS02800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IE337_RS02805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IE337_RS02815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IE337_RS02820	COG1799	cell septum assembly
IE337_RS02835	COG3599	regulation of cell shape
IE337_RS02840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IE337_RS02855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IE337_RS02865	COG2252	PERMEase
IE337_RS02875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IE337_RS02885	COG4537	Required for transformation and DNA binding
IE337_RS02895	COG0827	DNA restriction-modification system
IE337_RS02900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IE337_RS02905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IE337_RS02910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IE337_RS02910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IE337_RS02915	COG0631	protein serine/threonine phosphatase activity
IE337_RS02920	COG2815	serine threonine protein kinase
IE337_RS02920	COG0515	serine threonine protein kinase
IE337_RS02925	COG1162	GTPase activity
IE337_RS02930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IE337_RS02940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IE337_RS02950	COG1461	Dihydroxyacetone kinase
IE337_RS02955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IE337_RS02960	COG0416	fatty acid biosynthetic process
IE337_RS02965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IE337_RS02970	COG0571	ribonuclease III activity
IE337_RS02975	COG1196	nuclear chromosome segregation
IE337_RS02980	COG0552	protein localization to endoplasmic reticulum
IE337_RS02985	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
IE337_RS02990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IE337_RS02995	COG0228	four-way junction DNA binding
IE337_RS03000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IE337_RS03005	COG0336	Belongs to the RNA methyltransferase TrmD family
IE337_RS03010	COG0335	large ribosomal subunit rRNA binding
IE337_RS03015	COG1942	4-Oxalocrotonate Tautomerase
IE337_RS03020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IE337_RS03030	COG1428	Deoxynucleoside kinase
IE337_RS03065	COG1164	Oligoendopeptidase f
IE337_RS03080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IE337_RS03085	COG1846	Transcriptional regulator
IE337_RS03090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IE337_RS03095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IE337_RS03100	COG2070	2-Nitropropane dioxygenase
IE337_RS03110	COG1028	Short-chain dehydrogenase reductase Sdr
IE337_RS03115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IE337_RS03130	COG0439	Biotin carboxylase
IE337_RS03135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IE337_RS03140	COG0825	malonyl-CoA metabolic process
IE337_RS03145	COG0006	proline dipeptidase activity
IE337_RS03150	COG1609	Transcriptional regulator
IE337_RS03190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IE337_RS03195	COG3425	synthase
IE337_RS03210	COG0124	histidyl-tRNA synthetase
IE337_RS03215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IE337_RS03220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IE337_RS03225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IE337_RS03230	COG1610	YqeY-like protein
IE337_RS03235	COG1702	phosphate starvation-inducible protein PhoH
IE337_RS03240	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IE337_RS03245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IE337_RS03250	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IE337_RS03255	COG1381	Involved in DNA repair and RecF pathway recombination
IE337_RS03260	COG0752	glycyl-tRNA synthetase alpha subunit
IE337_RS03265	COG0751	glycine-tRNA ligase activity
IE337_RS03275	COG2706	6-phosphogluconolactonase activity
IE337_RS03280	COG0628	permease
IE337_RS03290	COG1674	ftsk spoiiie
IE337_RS03295	COG4152	abc transporter atp-binding protein
IE337_RS03300	COG1668	transmembrane transport
IE337_RS03305	COG0322	excinuclease ABC activity
IE337_RS03310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IE337_RS03315	COG1739	Uncharacterized protein family UPF0029
IE337_RS03325	COG2814	Major facilitator Superfamily
IE337_RS03330	COG0517	IMP dehydrogenase activity
IE337_RS03330	COG0516	GMP reductase activity
IE337_RS03335	COG0632	four-way junction helicase activity
IE337_RS03340	COG2255	four-way junction helicase activity
IE337_RS03345	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IE337_RS03385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IE337_RS03390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IE337_RS03395	COG0513	Belongs to the DEAD box helicase family
IE337_RS03400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IE337_RS03415	COG3906	Belongs to the UPF0473 family
IE337_RS03420	COG3906	Belongs to the UPF0473 family
IE337_RS03425	COG1555	photosystem II stabilization
IE337_RS03425	COG1596	polysaccharide export
IE337_RS03430	COG2333	competence protein COMEC
IE337_RS03430	COG0658	competence protein
IE337_RS03435	COG1466	dna polymerase III delta subunit
IE337_RS03440	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IE337_RS03445	COG0268	Binds directly to 16S ribosomal RNA
IE337_RS03465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IE337_RS03475	COG0544	peptidyl-prolyl cis-trans isomerase activity
IE337_RS03480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IE337_RS03485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IE337_RS03500	COG1193	negative regulation of DNA recombination
IE337_RS03505	COG3118	belongs to the thioredoxin family
IE337_RS03550	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IE337_RS03555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IE337_RS03565	COG2357	RelA SpoT domain protein
IE337_RS03575	COG0564	pseudouridine synthase activity
IE337_RS03580	COG2239	Acts as a magnesium transporter
IE337_RS03585	COG2814	Major facilitator Superfamily
IE337_RS03590	COG0779	Required for maturation of 30S ribosomal subunits
IE337_RS03595	COG0195	Participates in both transcription termination and antitermination
IE337_RS03600	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IE337_RS03610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IE337_RS03615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IE337_RS03620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE337_RS03625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IE337_RS03630	COG0196	riboflavin kinase activity
IE337_RS03635	COG1293	RNA-binding protein homologous to eukaryotic snRNP
IE337_RS03645	COG1307	EDD domain protein, DegV family
IE337_RS03650	COG1307	EDD domain protein, DegV family
IE337_RS03655	COG1307	EDD domain protein, DegV family
IE337_RS03660	COG4479	Belongs to the UPF0346 family
IE337_RS03670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IE337_RS03680	COG0758	DNA mediated transformation
IE337_RS03685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IE337_RS03690	COG4974	Belongs to the 'phage' integrase family
IE337_RS03700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IE337_RS03705	COG0187	DNA topoisomerase II activity
IE337_RS03710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IE337_RS03720	COG1227	inorganic diphosphatase activity
IE337_RS03730	COG4175	Glycine betaine
IE337_RS03730	COG3448	diguanylate cyclase activity
IE337_RS03745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IE337_RS03770	COG1011	Hydrolase
IE337_RS03780	COG5503	Protein of unknown function (DUF1447)
IE337_RS03790	COG0242	peptide deformylase activity
IE337_RS03800	COG0483	inositol monophosphate 1-phosphatase activity
IE337_RS03805	COG1217	gtp-binding protein TYPA
IE337_RS03810	COG0772	Belongs to the SEDS family
IE337_RS03815	COG4471	UPF0298 protein
IE337_RS03820	COG0742	ribosomal rna small subunit methyltransferase
IE337_RS03825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IE337_RS03830	COG3480	Lon protease (S16) C-terminal proteolytic domain
IE337_RS03835	COG0477	Major facilitator Superfamily
IE337_RS03840	COG0358	DNA primase activity
IE337_RS03845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IE337_RS03855	COG0745	RESPONSE REGULATOR receiver
IE337_RS03860	COG5002	protein histidine kinase activity
IE337_RS03865	COG0572	uridine kinase
IE337_RS03870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IE337_RS03885	COG0670	Belongs to the BI1 family
IE337_RS03890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IE337_RS03890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IE337_RS03930	COG1247	-acetyltransferase
IE337_RS03935	COG3579	cysteine-type endopeptidase activity
IE337_RS03940	COG1464	Belongs to the NlpA lipoprotein family
IE337_RS03945	COG0444	Belongs to the ABC transporter superfamily
IE337_RS03950	COG4608	Belongs to the ABC transporter superfamily
IE337_RS03955	COG0601	transmembrane transport
IE337_RS03960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE337_RS03975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IE337_RS03980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IE337_RS03995	COG0047	phosphoribosylformylglycinamidine synthase activity
IE337_RS04000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IE337_RS04010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IE337_RS04015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IE337_RS04020	COG0138	bifunctional purine biosynthesis protein purh
IE337_RS04025	COG0151	Belongs to the GarS family
IE337_RS04030	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IE337_RS04035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IE337_RS04035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IE337_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
IE337_RS04055	COG2610	gluconate transmembrane transporter activity
IE337_RS04065	COG0436	Aminotransferase
IE337_RS04070	COG2017	converts alpha-aldose to the beta-anomer
IE337_RS04125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IE337_RS04130	COG0237	dephospho-CoA kinase activity
IE337_RS04135	COG3611	Membrane attachment protein
IE337_RS04140	COG1484	DNA-dependent DNA replication
IE337_RS04155	COG0745	RESPONSE REGULATOR receiver
IE337_RS04160	COG5002	protein histidine kinase activity
IE337_RS04170	COG0531	amino acid
IE337_RS04175	COG0706	membrane insertase activity
IE337_RS04190	COG1304	FMN binding
IE337_RS04210	COG1199	ATP-dependent helicase activity
IE337_RS04210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IE337_RS04220	COG0017	Asparaginyl-tRNA synthetase
IE337_RS04235	COG3331	DNA recombination
IE337_RS04240	COG4474	Belongs to the UPF0398 family
IE337_RS04245	COG3599	regulation of cell shape
IE337_RS04255	COG0116	Belongs to the methyltransferase superfamily
IE337_RS04265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IE337_RS04280	COG0556	nucleotide-excision repair
IE337_RS04290	COG0537	adenosine 5'-monophosphoramidase activity
IE337_RS04295	COG1131	(ABC) transporter
IE337_RS04305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IE337_RS04310	COG1719	4-vinyl reductase, 4VR
IE337_RS04330	COG0561	phosphatase activity
IE337_RS04335	COG1442	glycosyl transferase family 8
IE337_RS04340	COG0531	amino acid
IE337_RS04345	COG0463	Glycosyl transferase, family 2
IE337_RS04350	COG2246	polysaccharide biosynthetic process
IE337_RS04365	COG0285	dihydrofolate synthase activity
IE337_RS04370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IE337_RS04395	COG1869	D-ribose catabolic process
IE337_RS04405	COG1090	epimerase
IE337_RS04425	COG0583	DNA-binding transcription factor activity
IE337_RS04435	COG0028	Belongs to the TPP enzyme family
IE337_RS04480	COG1694	Mazg nucleotide pyrophosphohydrolase
IE337_RS04485	COG1611	Belongs to the LOG family
IE337_RS04495	COG1028	Short-chain dehydrogenase reductase Sdr
IE337_RS04500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE337_RS04505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IE337_RS04510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IE337_RS04515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE337_RS04525	COG2171	N-acyltransferase activity
IE337_RS04530	COG0019	diaminopimelate decarboxylase activity
IE337_RS04535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IE337_RS04540	COG0527	aspartate kinase activity
IE337_RS04545	COG2807	transmembrane transport
IE337_RS04580	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE337_RS04580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE337_RS04595	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
IE337_RS04605	COG1696	Membrane protein involved in D-alanine export
IE337_RS04630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IE337_RS04635	COG1511	domain protein
IE337_RS04640	COG1959	2 iron, 2 sulfur cluster binding
IE337_RS04675	COG0726	polysaccharide deacetylase
IE337_RS04705	COG2936	dipeptidyl-peptidase activity
IE337_RS04715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IE337_RS04725	COG0488	(ABC) transporter
IE337_RS04735	COG1122	ATPase activity
IE337_RS04740	COG4720	Psort location CytoplasmicMembrane, score
IE337_RS04750	COG1136	(ABC) transporter
IE337_RS04750	COG0577	efflux transmembrane transporter activity
IE337_RS04755	COG1472	Belongs to the glycosyl hydrolase 3 family
IE337_RS04775	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IE337_RS04795	COG0024	Methionine aminopeptidase
IE337_RS04800	COG1113	amino acid transport
IE337_RS04835	COG1174	glycine betaine transport
IE337_RS04845	COG0577	efflux transmembrane transporter activity
IE337_RS04850	COG1136	(ABC) transporter
IE337_RS04850	COG0577	efflux transmembrane transporter activity
IE337_RS04860	COG0531	amino acid
IE337_RS04870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IE337_RS04895	COG0183	Belongs to the thiolase family
IE337_RS04905	COG0735	belongs to the Fur family
IE337_RS04910	COG0390	transport system, permease component
IE337_RS04915	COG4619	ABC transporter
IE337_RS04935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IE337_RS04940	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IE337_RS04965	COG3052	prosthetic group binding
IE337_RS04980	COG2390	Transcriptional regulator
IE337_RS04985	COG0463	Glycosyl transferase, family 2
IE337_RS04990	COG0577	efflux transmembrane transporter activity
IE337_RS04995	COG1136	(ABC) transporter
IE337_RS05005	COG0481	GTPase activity
IE337_RS05015	COG1028	Short-chain dehydrogenase reductase Sdr
IE337_RS05020	COG4708	membrane
IE337_RS05030	COG2814	Major facilitator Superfamily
IE337_RS05055	COG1309	transcriptional regulator
IE337_RS05060	COG2076	Multidrug Resistance protein
IE337_RS05065	COG2076	Multidrug Resistance protein
IE337_RS05070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IE337_RS05075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IE337_RS05090	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IE337_RS05100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IE337_RS05105	COG2195	Cleaves the N-terminal amino acid of tripeptides
IE337_RS05110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IE337_RS05115	COG2384	SAM-dependent methyltransferase
IE337_RS05120	COG0457	Tetratricopeptide repeat
IE337_RS05130	COG0419	ATPase involved in DNA repair
IE337_RS05135	COG0420	3'-5' exonuclease activity
IE337_RS05145	COG2807	transmembrane transport
IE337_RS05150	COG4720	Psort location CytoplasmicMembrane, score
IE337_RS05155	COG0351	phosphomethylpyrimidine kinase
IE337_RS05160	COG0741	lytic transglycosylase activity
IE337_RS05170	COG0741	lytic transglycosylase activity
IE337_RS05190	COG1160	GTP binding
IE337_RS05195	COG0539	negative regulation of cytoplasmic translation
IE337_RS05200	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IE337_RS05210	COG0514	ATP-dependent DNA helicase (RecQ)
IE337_RS05220	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IE337_RS05225	COG2323	membrane
IE337_RS05235	COG1187	pseudouridine synthase activity
IE337_RS05240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IE337_RS05250	COG0456	acetyltransferase
IE337_RS05260	COG2996	Protein conserved in bacteria
IE337_RS05275	COG0475	glutathione-regulated potassium exporter activity
IE337_RS05285	COG1490	D-aminoacyl-tRNA deacylase activity
IE337_RS05290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IE337_RS05295	COG0587	DNA-directed DNA polymerase activity
IE337_RS05310	COG0488	(ABC) transporter
IE337_RS05315	COG0617	tRNA 3'-terminal CCA addition
IE337_RS05320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IE337_RS05325	COG1316	TRANSCRIPTIONal
IE337_RS05330	COG3594	Acyltransferase
IE337_RS05340	COG0528	UMP kinase activity
IE337_RS05345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IE337_RS05350	COG0052	Belongs to the universal ribosomal protein uS2 family
IE337_RS05360	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IE337_RS05365	COG0204	Acyl-transferase
IE337_RS05375	COG4224	UPF0291 protein
IE337_RS05380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IE337_RS05390	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IE337_RS05390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IE337_RS05395	COG1234	tRNA 3'-trailer cleavage
IE337_RS05410	COG0484	heat shock protein binding
IE337_RS05415	COG0443	Heat shock 70 kDa protein
IE337_RS05420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IE337_RS05425	COG1420	regulation of RNA biosynthetic process
IE337_RS05450	COG1682	transport, permease protein
IE337_RS05455	COG1134	teichoic acid transport
IE337_RS05455	COG1388	LysM domain
IE337_RS05460	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IE337_RS05465	COG2309	aminopeptidase activity
IE337_RS05470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IE337_RS05475	COG0564	pseudouridine synthase activity
IE337_RS05480	COG1278	Cold shock
IE337_RS05490	COG2814	Major facilitator Superfamily
IE337_RS05495	COG0741	lytic transglycosylase activity
IE337_RS05500	COG1072	(Pantothenic acid kinase))
IE337_RS05505	COG3973	AAA domain
IE337_RS05510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IE337_RS05515	COG1058	Belongs to the CinA family
IE337_RS05515	COG1546	Belongs to the CinA family
IE337_RS05520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IE337_RS05525	COG1426	Protein conserved in bacteria
IE337_RS05530	COG0612	Peptidase, M16
IE337_RS05535	COG0612	Peptidase, M16
IE337_RS05545	COG1070	Carbohydrate kinase
IE337_RS05550	COG3481	metal-dependent phosphohydrolase, HD sub domain
IE337_RS05560	COG3679	Belongs to the UPF0342 family
IE337_RS05565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IE337_RS05570	COG1438	arginine binding
IE337_RS05575	COG0018	arginyl-trna synthetase
IE337_RS05585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IE337_RS05600	COG1597	lipid kinase activity
IE337_RS05605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IE337_RS05610	COG0154	amidase activity
IE337_RS05620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IE337_RS05620	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IE337_RS05625	COG0561	phosphatase activity
IE337_RS05645	COG0667	Aldo Keto reductase
IE337_RS05650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IE337_RS05655	COG0167	dihydroorotate dehydrogenase activity
IE337_RS05665	COG1122	ATPase activity
IE337_RS05675	COG2267	carboxylic ester hydrolase activity
IE337_RS05675	COG2226	methyltransferase
IE337_RS05680	COG0671	phosphoesterase, PA-phosphatase related
IE337_RS05690	COG3842	ATPase activity
IE337_RS05705	COG0710	3-dehydroquinate dehydratase activity
IE337_RS05710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IE337_RS05715	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IE337_RS05720	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IE337_RS05725	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IE337_RS05730	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IE337_RS05735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IE337_RS05750	COG4684	Psort location CytoplasmicMembrane, score
IE337_RS05755	COG0436	Aminotransferase
IE337_RS05760	COG0436	Aminotransferase
IE337_RS05770	COG1609	Transcriptional regulator
IE337_RS05775	COG0083	homoserine kinase activity
IE337_RS05780	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IE337_RS05795	COG0582	viral genome integration into host DNA
IE337_RS05885	COG1573	uracil-dna glycosylase
IE337_RS05905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE337_RS05905	COG1321	iron dependent repressor
IE337_RS05915	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IE337_RS05925	COG0673	inositol 2-dehydrogenase activity
IE337_RS05930	COG0588	phosphoglycerate mutase activity
IE337_RS05935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IE337_RS05940	COG0501	Belongs to the peptidase M48B family
IE337_RS05945	COG1704	LemA family
IE337_RS05950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IE337_RS05955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IE337_RS05960	COG0562	UDP-galactopyranose mutase
IE337_RS05965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IE337_RS05970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IE337_RS05980	COG0505	Belongs to the CarA family
IE337_RS05985	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IE337_RS05990	COG0564	pseudouridine synthase activity
IE337_RS06005	COG0328	RNA-DNA hybrid ribonuclease activity
IE337_RS06010	COG1136	(ABC) transporter
IE337_RS06040	COG1757	Na H antiporter
IE337_RS06045	COG1686	Belongs to the peptidase S11 family
IE337_RS06050	COG1757	Na H antiporter
IE337_RS06060	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IE337_RS06065	COG1113	amino acid transport
IE337_RS06070	COG2261	transglycosylase associated protein
IE337_RS06110	COG0254	rRNA binding
IE337_RS06120	COG0126	phosphoglycerate kinase activity
IE337_RS06150	COG0584	glycerophosphoryl diester phosphodiesterase
IE337_RS06165	COG1175	transmembrane transport
IE337_RS06170	COG3842	ATPase activity
IE337_RS06195	COG3716	PTS system mannose fructose sorbose family IID component
IE337_RS06200	COG3715	PTS system
IE337_RS06210	COG1027	Aspartate ammonia-lyase
IE337_RS06285	COG1368	sulfuric ester hydrolase activity
IE337_RS06295	COG0438	transferase activity, transferring glycosyl groups
IE337_RS06300	COG0438	transferase activity, transferring glycosyl groups
IE337_RS06310	COG0284	orotidine-5'-phosphate decarboxylase activity
IE337_RS06315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IE337_RS06320	COG0505	Belongs to the CarA family
IE337_RS06330	COG0540	Belongs to the ATCase OTCase family
IE337_RS06340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IE337_RS06345	COG4856	YbbR-like protein
IE337_RS06360	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IE337_RS06365	COG2176	DNA-directed DNA polymerase activity
IE337_RS06375	COG0802	atpase or kinase
IE337_RS06380	COG0280	phosphate acetyltransferase
IE337_RS06385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IE337_RS06390	COG1126	abc transporter atp-binding protein
IE337_RS06395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE337_RS06405	COG0557	exoribonuclease II activity
IE337_RS06415	COG0148	phosphopyruvate hydratase activity
IE337_RS06420	COG0149	triose-phosphate isomerase activity
IE337_RS06430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE337_RS06440	COG0492	ferredoxin-NADP+ reductase activity
IE337_RS06445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IE337_RS06450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IE337_RS06455	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IE337_RS06460	COG1950	PFAM Membrane protein of
IE337_RS06470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IE337_RS06475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IE337_RS06485	COG1177	transmembrane transport
IE337_RS06490	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE337_RS06495	COG3842	ATPase activity
IE337_RS06500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IE337_RS06505	COG0049	tRNA binding
IE337_RS06510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IE337_RS06515	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IE337_RS06520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IE337_RS06525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IE337_RS06530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IE337_RS06540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IE337_RS06545	COG0166	Belongs to the GPI family
IE337_RS06550	COG4975	Glucose uptake
IE337_RS06560	COG4493	Belongs to the UPF0637 family
IE337_RS06565	COG0668	transmembrane transport
IE337_RS06570	COG2076	Multidrug Resistance protein
IE337_RS06575	COG0386	Belongs to the glutathione peroxidase family
IE337_RS06580	COG0519	Catalyzes the synthesis of GMP from XMP
IE337_RS06605	COG1215	transferase activity, transferring glycosyl groups
IE337_RS06610	COG0438	transferase activity, transferring glycosyl groups
IE337_RS06615	COG1216	Glycosyl transferase, family 2
IE337_RS06655	COG3223	Belongs to the PsiE family
IE337_RS06685	COG0516	GMP reductase activity
IE337_RS06730	COG2217	Heavy metal translocating P-type atpase
IE337_RS06750	COG2183	response to ionizing radiation
IE337_RS06765	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IE337_RS06815	COG2176	DNA-directed DNA polymerase activity
IE337_RS06820	COG0442	prolyl-tRNA aminoacylation
IE337_RS06825	COG0750	zinc metalloprotease
IE337_RS06830	COG4589	Belongs to the CDS family
IE337_RS06835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IE337_RS06840	COG0561	phosphatase activity
IE337_RS06850	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IE337_RS06855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IE337_RS06860	COG2252	PERMEase
IE337_RS06870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IE337_RS06875	COG2188	Transcriptional regulator
IE337_RS06885	COG0561	phosphatase activity
IE337_RS06895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IE337_RS06900	COG0772	Belongs to the SEDS family
IE337_RS06910	COG1077	Cell shape determining protein MreB Mrl
IE337_RS06915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IE337_RS06920	COG0586	Pfam SNARE associated Golgi protein
IE337_RS06930	COG1682	transport, permease protein
IE337_RS06935	COG1388	LysM domain
IE337_RS06935	COG1134	teichoic acid transport
IE337_RS06940	COG4464	protein tyrosine phosphatase activity
IE337_RS06945	COG0489	protein tyrosine kinase activity
IE337_RS06955	COG0588	phosphoglycerate mutase activity
IE337_RS06960	COG0492	ferredoxin-NADP+ reductase activity
IE337_RS06970	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IE337_RS06975	COG2832	Protein of unknown function (DUF454)
IE337_RS06990	COG2814	Major facilitator Superfamily
IE337_RS06995	COG0305	Participates in initiation and elongation during chromosome replication
IE337_RS07000	COG0359	binds to the 23S rRNA
IE337_RS07010	COG4608	Belongs to the ABC transporter superfamily
IE337_RS07015	COG0444	Belongs to the ABC transporter superfamily
IE337_RS07020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE337_RS07025	COG0601	transmembrane transport
IE337_RS07030	COG4166	transmembrane transport
IE337_RS07040	COG2706	6-phosphogluconolactonase activity
IE337_RS07045	COG0765	amino acid transport
IE337_RS07050	COG0765	amino acid transport
IE337_RS07055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE337_RS07075	COG0194	GDP metabolic process
IE337_RS07080	COG1268	BioY protein
IE337_RS07100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IE337_RS07110	COG0180	Tryptophanyl-tRNA synthetase
IE337_RS07115	COG3973	AAA domain
IE337_RS07120	COG2337	Toxic component of a toxin-antitoxin (TA) module
IE337_RS07125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IE337_RS07135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IE337_RS07140	COG0504	CTP synthase activity
IE337_RS07145	COG3343	RNA polymerase activity
IE337_RS07150	COG0561	phosphatase activity
IE337_RS07155	COG1078	dGTPase activity
IE337_RS07165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IE337_RS07170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IE337_RS07185	COG5002	protein histidine kinase activity
IE337_RS07190	COG0745	RESPONSE REGULATOR receiver
IE337_RS07205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IE337_RS07210	COG0629	single-stranded DNA binding
IE337_RS07215	COG0360	Binds together with S18 to 16S ribosomal RNA
IE337_RS07220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IE337_RS07225	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IE337_RS07230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IE337_RS07235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IE337_RS07255	COG4975	Glucose uptake
IE337_RS07260	COG1064	alcohol dehydrogenase
IE337_RS07280	COG1074	ATP-dependent DNA helicase activity
IE337_RS07285	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IE337_RS07290	COG0531	amino acid
IE337_RS07295	COG0626	cystathionine gamma-synthase activity
IE337_RS07305	COG1073	alpha beta
IE337_RS07315	COG2235	arginine
IE337_RS07340	COG2244	polysaccharide biosynthetic process
IE337_RS07355	COG0495	leucyl-tRNA aminoacylation
IE337_RS07365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IE337_RS07385	COG1546	Belongs to the CinA family
IE337_RS07385	COG1058	Belongs to the CinA family
IE337_RS07390	COG4555	ABC transporter
IE337_RS07395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IE337_RS07400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IE337_RS07425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IE337_RS07430	COG2252	PERMEase
IE337_RS07445	COG2153	protein acetylation
IE337_RS07490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IE337_RS07495	COG2233	PERMEase
IE337_RS07515	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IE337_RS07520	COG1737	Transcriptional regulator
IE337_RS07575	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IE337_RS07580	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IE337_RS07595	COG0037	tRNA processing
IE337_RS07605	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IE337_RS07610	COG2244	polysaccharide biosynthetic process
IE337_RS07615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IE337_RS07620	COG0193	aminoacyl-tRNA hydrolase activity
IE337_RS07625	COG1511	domain protein
IE337_RS07625	COG1511	domain protein
IE337_RS07640	COG0277	FAD linked oxidase domain protein
IE337_RS07645	COG0577	efflux transmembrane transporter activity
IE337_RS07650	COG1136	(ABC) transporter
IE337_RS07650	COG0577	efflux transmembrane transporter activity
IE337_RS07690	COG1733	regulation of RNA biosynthetic process
IE337_RS07705	COG1968	undecaprenyl-diphosphatase activity
IE337_RS07715	COG0737	Belongs to the 5'-nucleotidase family
IE337_RS07740	COG1316	TRANSCRIPTIONal
IE337_RS07750	COG2131	deaminase
IE337_RS07760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IE337_RS07765	COG1253	flavin adenine dinucleotide binding
IE337_RS07770	COG1253	flavin adenine dinucleotide binding
IE337_RS07785	COG0084	hydrolase, TatD family'
IE337_RS07790	COG0025	NhaP-type Na H and K H
IE337_RS07795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IE337_RS07795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IE337_RS07840	COG1368	sulfuric ester hydrolase activity
IE337_RS07845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IE337_RS07850	COG0187	DNA topoisomerase II activity