locus-tag	class	description
OF848_RS00005	COG0583	DNA-binding transcription factor activity
OF848_RS00015	COG1473	amidohydrolase
OF848_RS00025	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
OF848_RS00065	COG1982	Orn Lys Arg decarboxylase major
OF848_RS00085	COG0483	inositol monophosphate 1-phosphatase activity
OF848_RS00095	COG1217	gtp-binding protein TYPA
OF848_RS00105	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
OF848_RS00110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OF848_RS00115	COG4838	Belongs to the UPF0358 family
OF848_RS00120	COG0772	Belongs to the SEDS family
OF848_RS00125	COG1612	heme a metabolic process
OF848_RS00130	COG0109	protoheme IX farnesyltransferase activity
OF848_RS00135	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OF848_RS00135	COG2010	Cytochrome c
OF848_RS00150	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OF848_RS00155	COG3336	cytochrome c oxidase
OF848_RS00165	COG2340	Cysteine-rich secretory protein family
OF848_RS00190	COG3679	Belongs to the UPF0342 family
OF848_RS00195	COG4471	UPF0298 protein
OF848_RS00205	COG0742	ribosomal rna small subunit methyltransferase
OF848_RS00210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OF848_RS00215	COG3314	Sporulation integral membrane protein YlbJ
OF848_RS00220	COG1752	Esterase of the alpha-beta hydrolase superfamily
OF848_RS00225	COG3480	Lon protease (S16) C-terminal proteolytic domain
OF848_RS00230	COG1323	Belongs to the UPF0348 family
OF848_RS00235	COG1399	metal-binding, possibly nucleic acid-binding protein
OF848_RS00240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OF848_RS00250	COG0454	-acetyltransferase
OF848_RS00255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OF848_RS00260	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
OF848_RS00265	COG2001	Belongs to the MraZ family
OF848_RS00270	COG0275	rRNA processing
OF848_RS00275	COG4839	cell division protein FtsL
OF848_RS00280	COG0768	penicillin binding
OF848_RS00285	COG0768	penicillin binding
OF848_RS00300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OF848_RS00305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OF848_RS00310	COG0772	Belongs to the SEDS family
OF848_RS00315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OF848_RS00320	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OF848_RS00325	COG0849	cell division
OF848_RS00330	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OF848_RS00340	COG1191	sigma factor activity
OF848_RS00345	COG1191	sigma factor activity
OF848_RS00350	COG1873	PFAM PRC-barrel domain
OF848_RS00355	COG3584	3D domain protein
OF848_RS00355	COG1388	LysM domain
OF848_RS00365	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OF848_RS00370	COG1799	cell septum assembly
OF848_RS00375	COG0762	integral membrane protein
OF848_RS00380	COG2302	S4 RNA-binding domain
OF848_RS00385	COG3599	regulation of cell shape
OF848_RS00400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OF848_RS00405	COG0564	pseudouridine synthase activity
OF848_RS00410	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
OF848_RS00415	COG0540	Belongs to the ATCase OTCase family
OF848_RS00420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OF848_RS00435	COG0543	2 iron, 2 sulfur cluster binding
OF848_RS00440	COG0167	dihydroorotate dehydrogenase activity
OF848_RS00450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OF848_RS00475	COG1803	Methylglyoxal synthase
OF848_RS00495	COG0477	Major facilitator Superfamily
OF848_RS00500	COG0477	Major facilitator Superfamily
OF848_RS00505	COG0628	permease
OF848_RS00520	COG0385	Bile acid
OF848_RS00530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OF848_RS00535	COG1561	YicC-like family, N-terminal region
OF848_RS00540	COG2052	Domain of unknown function (DUF370)
OF848_RS00545	COG0194	GDP metabolic process
OF848_RS00550	COG1758	RNA polymerase activity
OF848_RS00560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OF848_RS00565	COG0242	peptide deformylase activity
OF848_RS00570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OF848_RS00575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OF848_RS00575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OF848_RS00580	COG0631	protein serine/threonine phosphatase activity
OF848_RS00585	COG2815	serine threonine protein kinase
OF848_RS00585	COG0515	serine threonine protein kinase
OF848_RS00590	COG1162	GTPase activity
OF848_RS00595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OF848_RS00600	COG1564	THIamine pyrophosphokinase
OF848_RS00610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OF848_RS00620	COG1302	Protein conserved in bacteria
OF848_RS00630	COG1760	l-serine dehydratase
OF848_RS00635	COG1760	l-serine dehydratase
OF848_RS00640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OF848_RS00650	COG0416	fatty acid biosynthetic process
OF848_RS00655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OF848_RS00660	COG1028	Short-chain dehydrogenase reductase Sdr
OF848_RS00670	COG0571	ribonuclease III activity
OF848_RS00675	COG1196	nuclear chromosome segregation
OF848_RS00680	COG0552	protein localization to endoplasmic reticulum
OF848_RS00685	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
OF848_RS00690	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OF848_RS00695	COG0228	four-way junction DNA binding
OF848_RS00700	COG1837	Belongs to the UPF0109 family
OF848_RS00710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OF848_RS00715	COG0336	Belongs to the RNA methyltransferase TrmD family
OF848_RS00730	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
OF848_RS00745	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OF848_RS00750	COG0045	succinate-CoA ligase (ADP-forming) activity
OF848_RS00755	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OF848_RS00760	COG0758	DNA mediated transformation
OF848_RS00770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OF848_RS00775	COG4974	Belongs to the 'phage' integrase family
OF848_RS00780	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
OF848_RS00790	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
OF848_RS00795	COG1815	bacterial-type flagellum-dependent cell motility
OF848_RS00800	COG1558	bacterial-type flagellum-dependent cell motility
OF848_RS00805	COG1677	Flagellar hook-basal body complex protein FliE
OF848_RS00810	COG1766	The M ring may be actively involved in energy transduction
OF848_RS00820	COG1317	bacterial-type flagellum organization
OF848_RS00825	COG1157	protein secretion by the type III secretion system
OF848_RS00830	COG2882	bacterial-type flagellum organization
OF848_RS00845	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
OF848_RS00855	COG4786	Flagellar basal body rod
OF848_RS00865	COG1580	Controls the rotational direction of flagella during chemotaxis
OF848_RS00870	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OF848_RS00875	COG1776	CheC inhibitor of MCP methylation
OF848_RS00875	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OF848_RS00880	COG2201	protein-glutamate methylesterase activity
OF848_RS00885	COG3190	flagellar
OF848_RS00890	COG1338	Plays a role in the flagellum-specific transport system
OF848_RS00895	COG1987	bacterial-type flagellum assembly
OF848_RS00900	COG1684	flagellar biosynthetic protein fliR
OF848_RS00905	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OF848_RS00910	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OF848_RS00915	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OF848_RS00920	COG1419	protein localization to endoplasmic reticulum
OF848_RS00925	COG0455	bacterial-type flagellum organization
OF848_RS00930	COG2201	protein-glutamate methylesterase activity
OF848_RS00940	COG0835	chemotaxis
OF848_RS00945	COG1776	CheC inhibitor of MCP methylation
OF848_RS00950	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
OF848_RS00955	COG1191	sigma factor activity
OF848_RS00965	COG0052	Belongs to the universal ribosomal protein uS2 family
OF848_RS00970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OF848_RS00975	COG0528	UMP kinase activity
OF848_RS00980	COG0233	cytoplasmic translational termination
OF848_RS00985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OF848_RS00990	COG4589	Belongs to the CDS family
OF848_RS00995	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OF848_RS01000	COG0750	zinc metalloprotease
OF848_RS01005	COG0442	prolyl-tRNA aminoacylation
OF848_RS01010	COG2176	DNA-directed DNA polymerase activity
OF848_RS01015	COG0779	Required for maturation of 30S ribosomal subunits
OF848_RS01020	COG0195	Participates in both transcription termination and antitermination
OF848_RS01025	COG2740	Nucleic-acid-binding protein implicated in transcription termination
OF848_RS01030	COG1358	cellular component organization or biogenesis
OF848_RS01040	COG1550	Protein conserved in bacteria
OF848_RS01045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OF848_RS01050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OF848_RS01055	COG0196	riboflavin kinase activity
OF848_RS01060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OF848_RS01065	COG1185	polyribonucleotide nucleotidyltransferase activity
OF848_RS01070	COG0726	polysaccharide deacetylase
OF848_RS01075	COG0612	Peptidase, M16
OF848_RS01080	COG1873	PFAM PRC-barrel domain
OF848_RS01085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OF848_RS01095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OF848_RS01100	COG0527	aspartate kinase activity
OF848_RS01115	COG0740	serine-type endopeptidase activity
OF848_RS01125	COG1674	ftsk spoiiie
OF848_RS01125	COG4980	gas vesicle protein
OF848_RS01130	COG1744	ABC transporter substrate-binding protein PnrA-like
OF848_RS01140	COG4603	Belongs to the binding-protein-dependent transport system permease family
OF848_RS01145	COG1079	Belongs to the binding-protein-dependent transport system permease family
OF848_RS01150	COG0612	Peptidase, M16
OF848_RS01155	COG0612	Peptidase, M16
OF848_RS01175	COG1426	Protein conserved in bacteria
OF848_RS01180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OF848_RS01185	COG1546	Belongs to the CinA family
OF848_RS01185	COG1058	Belongs to the CinA family
OF848_RS01195	COG1418	mRNA catabolic process
OF848_RS01200	COG1692	metallophosphoesterase
OF848_RS01205	COG2359	stage V sporulation protein S
OF848_RS01210	COG0826	peptidase U32
OF848_RS01215	COG0826	peptidase U32
OF848_RS01220	COG0531	amino acid
OF848_RS01225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OF848_RS01230	COG4550	Control of competence regulator ComK, YlbF/YmcA
OF848_RS01240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OF848_RS01245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OF848_RS01265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OF848_RS01275	COG0464	growth
OF848_RS01280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OF848_RS01285	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
OF848_RS01290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OF848_RS01315	COG1321	iron dependent repressor
OF848_RS01320	COG2759	Belongs to the formate--tetrahydrofolate ligase family
OF848_RS01330	COG0488	(ABC) transporter
OF848_RS01350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OF848_RS01355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
OF848_RS01360	COG1272	protein, Hemolysin III
OF848_RS01365	COG2755	lipolytic protein G-D-S-L family
OF848_RS01375	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
OF848_RS01375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OF848_RS01380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OF848_RS01385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OF848_RS01395	COG0840	transmembrane signaling receptor activity
OF848_RS01400	COG4479	Belongs to the UPF0346 family
OF848_RS01415	COG1876	peptidase activity
OF848_RS01420	COG3409	Peptidoglycan-binding domain 1 protein
OF848_RS01420	COG0793	Belongs to the peptidase S41A family
OF848_RS01425	COG1846	Transcriptional regulator
OF848_RS01430	COG2340	Cysteine-rich secretory protein family
OF848_RS01435	COG0534	Mate efflux family protein
OF848_RS01450	COG1793	dna ligase
OF848_RS01450	COG3285	dna ligase
OF848_RS01455	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
OF848_RS01460	COG0671	phosphoesterase, PA-phosphatase related
OF848_RS01465	COG1368	sulfuric ester hydrolase activity
OF848_RS01470	COG1331	Highly conserved protein containing a thioredoxin domain
OF848_RS01475	COG2814	Major facilitator Superfamily
OF848_RS01485	COG0745	RESPONSE REGULATOR receiver
OF848_RS01490	COG5002	protein histidine kinase activity
OF848_RS01505	COG0567	Dehydrogenase, E1 component
OF848_RS01510	COG0508	dehydrogenase complex catalyzes the overall conversion of
OF848_RS01535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OF848_RS01545	COG1054	Belongs to the UPF0176 family
OF848_RS01550	COG2135	peptidase activity
OF848_RS01560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OF848_RS01565	COG0517	IMP dehydrogenase activity
OF848_RS01565	COG0516	GMP reductase activity
OF848_RS01570	COG0723	plastoquinol--plastocyanin reductase activity
OF848_RS01570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OF848_RS01580	COG3584	3D domain protein
OF848_RS01580	COG1388	LysM domain
OF848_RS01585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OF848_RS01590	COG1113	amino acid transport
OF848_RS01595	COG0598	Magnesium transport protein CorA
OF848_RS01605	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
OF848_RS01610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OF848_RS01620	COG0131	Imidazoleglycerol-phosphate dehydratase
OF848_RS01625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OF848_RS01640	COG0140	phosphoribosyl-ATP diphosphatase activity
OF848_RS01640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OF848_RS01650	COG2391	methyltransferase activity
OF848_RS01655	COG2962	Rard protein
OF848_RS01660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OF848_RS01665	COG0569	domain protein
OF848_RS01685	COG2807	transmembrane transport
OF848_RS01690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OF848_RS01700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OF848_RS01710	COG1278	Cold shock
OF848_RS01715	COG0302	gtp cyclohydrolase
OF848_RS01720	COG3634	alkyl hydroperoxide reductase activity
OF848_RS01735	COG0577	efflux transmembrane transporter activity
OF848_RS01740	COG1136	(ABC) transporter
OF848_RS01745	COG0642	Histidine kinase
OF848_RS01750	COG0745	RESPONSE REGULATOR receiver
OF848_RS01755	COG1113	amino acid transport
OF848_RS01765	COG0477	Major facilitator Superfamily
OF848_RS01775	COG1132	(ABC) transporter
OF848_RS01780	COG1132	(ABC) transporter
OF848_RS01790	COG1380	Effector of murein hydrolase LrgA
OF848_RS01795	COG1346	cytolysis
OF848_RS01800	COG0318	PFAM AMP-dependent synthetase and ligase
OF848_RS01825	COG2309	aminopeptidase activity
OF848_RS01835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OF848_RS01855	COG0824	Thioesterase
OF848_RS01865	COG4841	protein insertion into membrane
OF848_RS01870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OF848_RS01875	COG1832	CoA-binding protein
OF848_RS01880	COG0187	DNA topoisomerase II activity
OF848_RS01900	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OF848_RS01935	COG0681	Belongs to the peptidase S26 family
OF848_RS01955	COG0456	acetyltransferase
OF848_RS01960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OF848_RS01965	COG0456	acetyltransferase
OF848_RS01975	COG1028	Short-chain dehydrogenase reductase Sdr
OF848_RS01985	COG0351	phosphomethylpyrimidine kinase
OF848_RS01990	COG0352	thiamine-phosphate diphosphorylase activity
OF848_RS02000	COG2258	MOSC domain
OF848_RS02040	COG1309	transcriptional regulator
OF848_RS02045	COG2814	Major facilitator Superfamily
OF848_RS02050	COG2814	Major facilitator Superfamily
OF848_RS02060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OF848_RS02065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OF848_RS02080	COG2045	Belongs to the ComB family
OF848_RS02085	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OF848_RS02090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OF848_RS02115	COG0697	spore germination
OF848_RS02120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OF848_RS02125	COG0022	dehydrogenase e1 component
OF848_RS02130	COG0508	dehydrogenase complex catalyzes the overall conversion of
OF848_RS02135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OF848_RS02145	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
OF848_RS02145	COG3264	Mechanosensitive ion channel
OF848_RS02160	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
OF848_RS02175	COG0183	Belongs to the thiolase family
OF848_RS02180	COG0318	PFAM AMP-dependent synthetase and ligase
OF848_RS02190	COG0561	phosphatase activity
OF848_RS02215	COG2322	membrane
OF848_RS02230	COG0039	L-malate dehydrogenase activity
OF848_RS02235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OF848_RS02235	COG0475	glutathione-regulated potassium exporter activity
OF848_RS02265	COG0589	response to stress
OF848_RS02285	COG0583	DNA-binding transcription factor activity
OF848_RS02325	COG0640	Transcriptional regulator
OF848_RS02330	COG0798	PFAM Bile acid sodium symporter
OF848_RS02335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OF848_RS02375	COG1028	Short-chain dehydrogenase reductase Sdr
OF848_RS02380	COG2223	nitrite transmembrane transporter activity
OF848_RS02385	COG3773	Cell wall hydrolase
OF848_RS02390	COG0708	Exodeoxyribonuclease III
OF848_RS02395	COG2084	Dehydrogenase
OF848_RS02400	COG0297	glycogen (starch) synthase activity
OF848_RS02405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OF848_RS02410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OF848_RS02415	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OF848_RS02435	COG1247	-acetyltransferase
OF848_RS02440	COG0494	nUDIX hydrolase
OF848_RS02450	COG0783	Belongs to the Dps family
OF848_RS02460	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
OF848_RS02465	COG1131	(ABC) transporter
OF848_RS02495	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OF848_RS02505	COG1028	Short-chain dehydrogenase reductase Sdr
OF848_RS02520	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
OF848_RS02525	COG0709	Synthesizes selenophosphate from selenide and ATP
OF848_RS02535	COG0701	Predicted permease
OF848_RS02540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OF848_RS02545	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OF848_RS02555	COG1252	NADH dehydrogenase
OF848_RS02560	COG2404	hydrolase activity, acting on ester bonds
OF848_RS02570	COG4990	cell redox homeostasis
OF848_RS02575	COG0789	Transcriptional regulator
OF848_RS02605	COG0436	Aminotransferase
OF848_RS02610	COG0165	Argininosuccinate lyase
OF848_RS02615	COG0137	argininosuccinate synthase activity
OF848_RS02620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OF848_RS02625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OF848_RS02630	COG0505	Belongs to the CarA family
OF848_RS02635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OF848_RS02640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OF848_RS02645	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OF848_RS02650	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OF848_RS02685	COG1619	proteins homologs of microcin C7 resistance protein MccF
OF848_RS02690	COG2027	D-alanyl-D-alanine carboxypeptidase
OF848_RS02695	COG0204	Acyl-transferase
OF848_RS02705	COG4846	Membrane protein involved in cytochrome C biogenesis
OF848_RS02710	COG2201	protein-glutamate methylesterase activity
OF848_RS02715	COG0785	Cytochrome C biogenesis protein
OF848_RS02720	COG3763	UPF0154 protein
OF848_RS02735	COG4224	UPF0291 protein
OF848_RS02740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OF848_RS02750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OF848_RS02755	COG0174	glutamine synthetase
OF848_RS02760	COG0789	Transcriptional regulator
OF848_RS02765	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
OF848_RS02770	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
OF848_RS02785	COG2233	PERMEase
OF848_RS02795	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
OF848_RS02800	COG0116	Belongs to the methyltransferase superfamily
OF848_RS02815	COG4474	Belongs to the UPF0398 family
OF848_RS02825	COG3359	exonuclease
OF848_RS02835	COG0071	Belongs to the small heat shock protein (HSP20) family
OF848_RS02860	COG3331	DNA recombination
OF848_RS02865	COG4499	WXG100 protein secretion system (Wss), protein YukC
OF848_RS02865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OF848_RS02875	COG3935	DnaD domain protein
OF848_RS02880	COG0017	Asparaginyl-tRNA synthetase
OF848_RS02895	COG1199	ATP-dependent helicase activity
OF848_RS02895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OF848_RS02900	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OF848_RS02905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OF848_RS02925	COG0438	transferase activity, transferring glycosyl groups
OF848_RS02930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
OF848_RS02935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OF848_RS02940	COG1694	Mazg nucleotide pyrophosphohydrolase
OF848_RS02945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OF848_RS02955	COG2738	Putative neutral zinc metallopeptidase
OF848_RS02965	COG4347	Protein of unknown function (DUF1405)
OF848_RS02975	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OF848_RS02990	COG5582	Belongs to the UPF0302 family
OF848_RS02995	COG0457	Tetratricopeptide repeat
OF848_RS03000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OF848_RS03005	COG0287	Prephenate dehydrogenase
OF848_RS03010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OF848_RS03015	COG4401	Chorismate mutase type I
OF848_RS03025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OF848_RS03030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OF848_RS03035	COG0105	UTP biosynthetic process
OF848_RS03040	COG0142	geranyltranstransferase activity
OF848_RS03045	COG2226	methyltransferase
OF848_RS03055	COG0142	geranyltranstransferase activity
OF848_RS03065	COG0776	regulation of translation
OF848_RS03070	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
OF848_RS03110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OF848_RS03120	COG2959	enzyme of heme biosynthesis
OF848_RS03125	COG3409	Peptidoglycan-binding domain 1 protein
OF848_RS03125	COG3773	Cell wall hydrolase
OF848_RS03130	COG2339	peptidase activity
OF848_RS03135	COG0492	ferredoxin-NADP+ reductase activity
OF848_RS03140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OF848_RS03150	COG1408	metallophosphoesterase
OF848_RS03165	COG3546	catalase activity
OF848_RS03180	COG1266	CAAX protease self-immunity
OF848_RS03185	COG0514	ATP-dependent DNA helicase (RecQ)
OF848_RS03205	COG1141	Ferredoxin
OF848_RS03210	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
OF848_RS03215	COG0739	heme binding
OF848_RS03215	COG0741	lytic transglycosylase activity
OF848_RS03215	COG1196	nuclear chromosome segregation
OF848_RS03220	COG5002	protein histidine kinase activity
OF848_RS03225	COG0745	RESPONSE REGULATOR receiver
OF848_RS03230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OF848_RS03235	COG1333	cytochrome c biogenesis protein
OF848_RS03240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF848_RS03245	COG1187	pseudouridine synthase activity
OF848_RS03250	COG0700	Nucleoside recognition
OF848_RS03255	COG2715	membrane protein required for spore maturation
OF848_RS03260	COG1686	Belongs to the peptidase S11 family
OF848_RS03265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OF848_RS03290	COG0697	spore germination
OF848_RS03310	COG1191	sigma factor activity
OF848_RS03325	COG1686	Belongs to the peptidase S11 family
OF848_RS03330	COG4974	Belongs to the 'phage' integrase family
OF848_RS03340	COG0735	belongs to the Fur family
OF848_RS03345	COG1300	Membrane
OF848_RS03350	COG1379	DNA repair
OF848_RS03365	COG0667	Aldo Keto reductase
OF848_RS03375	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
OF848_RS03380	COG3853	Toxic anion resistance protein (TelA)
OF848_RS03385	COG1073	alpha beta
OF848_RS03390	COG1388	LysM domain
OF848_RS03390	COG3858	chitin binding
OF848_RS03400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OF848_RS03405	COG0300	oxidoreductase activity
OF848_RS03410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OF848_RS03420	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OF848_RS03435	COG2195	Cleaves the N-terminal amino acid of tripeptides
OF848_RS03450	COG1376	ErfK ybiS ycfS ynhG family protein
OF848_RS03460	COG1105	Belongs to the carbohydrate kinase PfkB family
OF848_RS03465	COG0508	dehydrogenase complex catalyzes the overall conversion of
OF848_RS03470	COG0022	dehydrogenase e1 component
OF848_RS03475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OF848_RS03480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OF848_RS03490	COG3290	protein histidine kinase activity
OF848_RS03490	COG3829	transcription factor binding
OF848_RS03505	COG0584	glycerophosphoryl diester phosphodiesterase
OF848_RS03510	COG0745	RESPONSE REGULATOR receiver
OF848_RS03515	COG0750	zinc metalloprotease
OF848_RS03520	COG0497	DNA recombination
OF848_RS03530	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
OF848_RS03535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OF848_RS03550	COG1570	exodeoxyribonuclease VII activity
OF848_RS03555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OF848_RS03565	COG1302	Protein conserved in bacteria
OF848_RS03570	COG0439	Biotin carboxylase
OF848_RS03575	COG0511	ligase activity, forming carbon-carbon bonds
OF848_RS03615	COG3854	ATPases associated with a variety of cellular activities
OF848_RS03620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OF848_RS03625	COG0006	proline dipeptidase activity
OF848_RS03630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
OF848_RS03640	COG3872	metal-dependent enzyme
OF848_RS03650	COG1752	Esterase of the alpha-beta hydrolase superfamily
OF848_RS03680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OF848_RS03685	COG0095	Lipoate-protein ligase
OF848_RS03695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OF848_RS03705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OF848_RS03710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OF848_RS03725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OF848_RS03750	COG4537	Required for transformation and DNA binding
OF848_RS03755	COG1459	type II secretion system
OF848_RS03760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OF848_RS03775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OF848_RS03785	COG1940	carbohydrate kinase activity
OF848_RS03790	COG4483	Protein conserved in bacteria
OF848_RS03795	COG0457	Tetratricopeptide repeat
OF848_RS03795	COG0705	Rhomboid family
OF848_RS03805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OF848_RS03815	COG0768	penicillin binding
OF848_RS03820	COG0477	Major facilitator Superfamily
OF848_RS03825	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OF848_RS03835	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
OF848_RS03840	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
OF848_RS03845	COG0735	belongs to the Fur family
OF848_RS03850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OF848_RS03855	COG1121	(ABC) transporter
OF848_RS03865	COG0791	NLP P60 protein
OF848_RS03865	COG3883	PFAM NLP P60 protein
OF848_RS03870	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
OF848_RS03875	COG0513	Belongs to the DEAD box helicase family
OF848_RS03885	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OF848_RS03890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OF848_RS03900	COG2010	Cytochrome c
OF848_RS03910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OF848_RS03915	COG0358	DNA primase activity
OF848_RS03925	COG0517	IMP dehydrogenase activity
OF848_RS03935	COG1381	Involved in DNA repair and RecF pathway recombination
OF848_RS03945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OF848_RS03950	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OF848_RS03955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OF848_RS03960	COG1480	7TM receptor with intracellular HD hydrolase
OF848_RS03970	COG1702	phosphate starvation-inducible protein PhoH
OF848_RS03985	COG1610	YqeY-like protein
OF848_RS03995	COG1254	Belongs to the acylphosphatase family
OF848_RS04000	COG1283	sodium-dependent phosphate transmembrane transporter activity
OF848_RS04005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OF848_RS04010	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OF848_RS04015	COG2264	protein methyltransferase activity
OF848_RS04025	COG0443	Heat shock 70 kDa protein
OF848_RS04030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OF848_RS04040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OF848_RS04045	COG0481	GTPase activity
OF848_RS04050	COG0860	N-Acetylmuramoyl-L-alanine amidase
OF848_RS04055	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
OF848_RS04060	COG0268	Binds directly to 16S ribosomal RNA
OF848_RS04065	COG1466	dna polymerase III delta subunit
OF848_RS04075	COG2333	competence protein COMEC
OF848_RS04075	COG0658	competence protein
OF848_RS04080	COG2131	deaminase
OF848_RS04085	COG1596	polysaccharide export
OF848_RS04085	COG1555	photosystem II stabilization
OF848_RS04090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OF848_RS04095	COG2226	methyltransferase
OF848_RS04105	COG1713	HD superfamily hydrolase involved in NAD metabolism
OF848_RS04110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OF848_RS04115	COG1534	Rna-binding protein
OF848_RS04125	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
OF848_RS04130	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
OF848_RS04135	COG0247	lactate metabolic process
OF848_RS04140	COG0277	FAD linked oxidase domain protein
OF848_RS04145	COG3835	regulator
OF848_RS04150	COG2132	Multicopper oxidase
OF848_RS04155	COG0071	Belongs to the small heat shock protein (HSP20) family
OF848_RS04165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF848_RS04175	COG1704	LemA family
OF848_RS04205	COG1183	phosphatidylcholine synthase activity
OF848_RS04215	COG3634	alkyl hydroperoxide reductase activity
OF848_RS04220	COG0450	alkyl hydroperoxide reductase
OF848_RS04235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OF848_RS04250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OF848_RS04255	COG0572	uridine kinase
OF848_RS04260	COG4122	O-methyltransferase activity
OF848_RS04265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OF848_RS04270	COG3906	Belongs to the UPF0473 family
OF848_RS04275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OF848_RS04280	COG4472	Bacterial protein of unknown function (DUF965)
OF848_RS04285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OF848_RS04290	COG0628	permease
OF848_RS04315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OF848_RS04320	COG1477	protein flavinylation
OF848_RS04320	COG0457	Tetratricopeptide repeat
OF848_RS04325	COG0482	sulfurtransferase activity
OF848_RS04330	COG1104	cysteine desulfurase activity
OF848_RS04335	COG1959	2 iron, 2 sulfur cluster binding
OF848_RS04350	COG0697	spore germination
OF848_RS04365	COG0425	Belongs to the sulfur carrier protein TusA family
OF848_RS04370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OF848_RS04370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OF848_RS04375	COG2210	Belongs to the sulfur carrier protein TusA family
OF848_RS04380	COG0425	Belongs to the sulfur carrier protein TusA family
OF848_RS04380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OF848_RS04385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OF848_RS04390	COG1937	Protein conserved in bacteria
OF848_RS04410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF848_RS04420	COG0785	Cytochrome C biogenesis protein
OF848_RS04435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF848_RS04460	COG1028	Short-chain dehydrogenase reductase Sdr
OF848_RS04470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OF848_RS04475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OF848_RS04480	COG0385	Bile acid
OF848_RS04490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OF848_RS04495	COG0124	histidyl-tRNA synthetase
OF848_RS04505	COG4991	sh3 domain protein
OF848_RS04505	COG3103	Sh3 type 3 domain protein
OF848_RS04505	COG0860	N-Acetylmuramoyl-L-alanine amidase
OF848_RS04510	COG2814	Major facilitator Superfamily
OF848_RS04515	COG1566	PFAM secretion protein HlyD family protein
OF848_RS04520	COG1846	Transcriptional regulator
OF848_RS04525	COG1490	D-aminoacyl-tRNA deacylase activity
OF848_RS04530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OF848_RS04535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OF848_RS04540	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
OF848_RS04540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OF848_RS04545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OF848_RS04545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OF848_RS04555	COG2244	polysaccharide biosynthetic process
OF848_RS04560	COG2323	membrane
OF848_RS04570	COG1862	Preprotein translocase
OF848_RS04575	COG0343	queuine tRNA-ribosyltransferase activity
OF848_RS04580	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
OF848_RS04595	COG0632	four-way junction helicase activity
OF848_RS04600	COG0217	transcriptional regulatory protein
OF848_RS04615	COG1827	regulation of RNA biosynthetic process
OF848_RS04620	COG0077	Prephenate dehydratase
OF848_RS04625	COG4492	Belongs to the UPF0735 family
OF848_RS04630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OF848_RS04635	COG3290	protein histidine kinase activity
OF848_RS04640	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OF848_RS04650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OF848_RS04655	COG1530	ribonuclease E activity
OF848_RS04665	COG1994	Peptidase M50
OF848_RS04675	COG2894	cell division
OF848_RS04680	COG0850	regulation of cytokinetic process
OF848_RS04690	COG1792	Involved in formation and maintenance of cell shape
OF848_RS04695	COG1077	Cell shape determining protein MreB Mrl
OF848_RS04720	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
OF848_RS04745	COG1459	type II secretion system
OF848_RS04755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OF848_RS04795	COG0285	dihydrofolate synthase activity
OF848_RS04800	COG0525	valine-tRNA ligase activity
OF848_RS04815	COG1388	LysM domain
OF848_RS04815	COG1388	LysM domain
OF848_RS04820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OF848_RS04825	COG0113	porphobilinogen synthase activity
OF848_RS04835	COG0181	hydroxymethylbilane synthase activity
OF848_RS04840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OF848_RS04855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OF848_RS04860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
OF848_RS04865	COG1067	ATP-dependent peptidase activity
OF848_RS04865	COG0470	DNA polymerase III
OF848_RS04875	COG0544	peptidyl-prolyl cis-trans isomerase activity
OF848_RS04880	COG1477	protein flavinylation
OF848_RS04880	COG0457	Tetratricopeptide repeat
OF848_RS04900	COG0622	Phosphoesterase
OF848_RS04905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OF848_RS04910	COG5401	PFAM Sporulation and spore germination
OF848_RS04920	COG1846	Transcriptional regulator
OF848_RS04950	COG2197	response regulator
OF848_RS04955	COG0824	Thioesterase
OF848_RS04960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OF848_RS04965	COG1053	succinate dehydrogenase
OF848_RS04970	COG2009	succinate dehydrogenase
OF848_RS04975	COG1719	4-vinyl reductase, 4VR
OF848_RS04985	COG0322	excinuclease ABC activity
OF848_RS04990	COG3118	belongs to the thioredoxin family
OF848_RS04995	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OF848_RS05000	COG2086	electron transfer activity
OF848_RS05005	COG1024	Enoyl-CoA hydratase
OF848_RS05010	COG1309	transcriptional regulator
OF848_RS05015	COG0318	PFAM AMP-dependent synthetase and ligase
OF848_RS05020	COG1193	negative regulation of DNA recombination
OF848_RS05025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
OF848_RS05025	COG1796	DNA polymerase
OF848_RS05030	COG1286	toxin biosynthetic process
OF848_RS05035	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
OF848_RS05060	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OF848_RS05065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OF848_RS05100	COG1695	Transcriptional regulator
OF848_RS05120	COG0431	NADPH-dependent FMN reductase
OF848_RS05125	COG1363	Peptidase, m42
OF848_RS05140	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
OF848_RS05150	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OF848_RS05160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OF848_RS05170	COG1484	DNA-dependent DNA replication
OF848_RS05175	COG3611	Membrane attachment protein
OF848_RS05180	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OF848_RS05190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OF848_RS05195	COG0237	dephospho-CoA kinase activity
OF848_RS05200	COG1971	Probably functions as a manganese efflux pump
OF848_RS05205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OF848_RS05210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OF848_RS05210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OF848_RS05220	COG0039	L-malate dehydrogenase activity
OF848_RS05225	COG0538	isocitrate dehydrogenase activity
OF848_RS05230	COG0372	Belongs to the citrate synthase family
OF848_RS05235	COG2707	UPF0756 membrane protein
OF848_RS05240	COG0628	permease
OF848_RS05250	COG0205	6-phosphofructokinase activity
OF848_RS05255	COG0825	malonyl-CoA metabolic process
OF848_RS05260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OF848_RS05265	COG0281	malic enzyme
OF848_RS05270	COG0587	DNA-directed DNA polymerase activity
OF848_RS05285	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
OF848_RS05295	COG4109	DRTGG domain
OF848_RS05300	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
OF848_RS05305	COG0006	proline dipeptidase activity
OF848_RS05315	COG0589	response to stress
OF848_RS05325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OF848_RS05330	COG0827	DNA restriction-modification system
OF848_RS05335	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
OF848_RS05340	COG3874	Sporulation protein YtfJ
OF848_RS05350	COG1714	RDD family
OF848_RS05355	COG0616	signal peptide processing
OF848_RS05360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OF848_RS05370	COG0301	tRNA thio-modification
OF848_RS05375	COG1104	cysteine desulfurase activity
OF848_RS05380	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
OF848_RS05385	COG1309	transcriptional regulator
OF848_RS05390	COG1956	GAF domain-containing protein
OF848_RS05395	COG2203	Gaf domain
OF848_RS05395	COG2199	diguanylate cyclase activity
OF848_RS05400	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OF848_RS05415	COG0506	proline dehydrogenase activity
OF848_RS05420	COG1012	belongs to the aldehyde dehydrogenase family
OF848_RS05425	COG3290	protein histidine kinase activity
OF848_RS05425	COG3829	transcription factor binding
OF848_RS05435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OF848_RS05445	COG2427	Protein of unknown function (DUF1641)
OF848_RS05450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OF848_RS05455	COG0315	cyclic pyranopterin monophosphate synthase activity
OF848_RS05460	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OF848_RS05465	COG0314	molybdopterin synthase activity
OF848_RS05470	COG1763	Mo-molybdopterin cofactor biosynthetic process
OF848_RS05475	COG0303	'Molybdopterin
OF848_RS05490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OF848_RS05495	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
OF848_RS05500	COG4149	molybdate abc transporter
OF848_RS05510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OF848_RS05515	COG0454	-acetyltransferase
OF848_RS05520	COG0517	IMP dehydrogenase activity
OF848_RS05525	COG0123	including yeast histone deacetylase and acetoin utilization protein
OF848_RS05535	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
OF848_RS05535	COG1605	Chorismate mutase
OF848_RS05540	COG4980	gas vesicle protein
OF848_RS05550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OF848_RS05555	COG1674	ftsk spoiiie
OF848_RS05565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OF848_RS05570	COG4848	Belongs to the UPF0354 family
OF848_RS05575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF848_RS05580	COG2208	phosphoserine phosphatase activity
OF848_RS05585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OF848_RS05590	COG5002	protein histidine kinase activity
OF848_RS05590	COG0784	Response regulator, receiver
OF848_RS05595	COG5584	Small secreted protein
OF848_RS05600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OF848_RS05605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OF848_RS05615	COG0510	thiamine kinase activity
OF848_RS05640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OF848_RS05645	COG1349	DNA-binding transcription factor activity
OF848_RS05665	COG0495	leucyl-tRNA aminoacylation
OF848_RS05670	COG2814	Major facilitator Superfamily
OF848_RS05680	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
OF848_RS05695	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OF848_RS05700	COG0367	asparagine synthase
OF848_RS05705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OF848_RS05730	COG1506	peptidase
OF848_RS05735	COG0655	NAD(P)H dehydrogenase (quinone) activity
OF848_RS05745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OF848_RS05750	COG1116	anion transmembrane transporter activity
OF848_RS05755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OF848_RS05770	COG0783	Belongs to the Dps family
OF848_RS05775	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
OF848_RS05785	COG0803	Belongs to the bacterial solute-binding protein 9 family
OF848_RS05795	COG4948	Mandelate Racemase Muconate Lactonizing
OF848_RS05800	COG0318	PFAM AMP-dependent synthetase and ligase
OF848_RS05805	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OF848_RS05810	COG0596	Alpha beta hydrolase
OF848_RS05815	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
OF848_RS05820	COG1169	isochorismate synthase
OF848_RS05830	COG1575	Belongs to the MenA family. Type 1 subfamily
OF848_RS05975	COG1285	pathogenesis
OF848_RS05990	COG2217	Heavy metal translocating P-type atpase
OF848_RS05995	COG2608	mercury ion transmembrane transporter activity
OF848_RS06005	COG1522	sequence-specific DNA binding
OF848_RS06025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OF848_RS06060	COG5002	protein histidine kinase activity
OF848_RS06070	COG1388	LysM domain
OF848_RS06085	COG0726	polysaccharide deacetylase
OF848_RS06115	COG0038	chloride channel
OF848_RS06125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OF848_RS06130	COG1937	Protein conserved in bacteria
OF848_RS06135	COG1525	nuclease
OF848_RS06140	COG2190	(PTS) system
OF848_RS06165	COG1028	Short-chain dehydrogenase reductase Sdr
OF848_RS06170	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
OF848_RS06185	COG1012	belongs to the aldehyde dehydrogenase family
OF848_RS06205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OF848_RS06215	COG2155	Conserved Protein
OF848_RS06225	COG1098	S1 RNA binding domain
OF848_RS06235	COG1902	pentaerythritol trinitrate reductase activity
OF848_RS06240	COG0656	L-ascorbic acid biosynthetic process
OF848_RS06260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OF848_RS06305	COG2814	Major facilitator Superfamily
OF848_RS06310	COG2050	protein possibly involved in aromatic compounds catabolism
OF848_RS06325	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OF848_RS06335	COG0697	spore germination
OF848_RS06345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OF848_RS06350	COG3584	3D domain protein
OF848_RS06360	COG1252	NADH dehydrogenase
OF848_RS06365	COG0492	ferredoxin-NADP+ reductase activity
OF848_RS06380	COG0726	polysaccharide deacetylase
OF848_RS06420	COG4837	Protein of unknown function (DUF1462)
OF848_RS06435	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
OF848_RS06440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OF848_RS06445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OF848_RS06450	COG0647	UMP catabolic process
OF848_RS06455	COG2445	Protein of unknown function DUF86
OF848_RS06460	COG4470	Protein conserved in bacteria
OF848_RS06465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
OF848_RS06470	COG0739	heme binding
OF848_RS06480	COG3377	Domain of unknown function (DUF1805)
OF848_RS06485	COG0737	Belongs to the 5'-nucleotidase family
OF848_RS06490	COG0719	Fe-S assembly protein
OF848_RS06495	COG0822	iron-sulfur transferase activity
OF848_RS06500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OF848_RS06505	COG0719	Fe-S assembly protein
OF848_RS06510	COG0396	ATPase activity
OF848_RS06520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF848_RS06525	COG0509	glycine decarboxylation via glycine cleavage system
OF848_RS06530	COG1393	Belongs to the ArsC family
OF848_RS06535	COG1960	acyl-CoA dehydrogenase activity
OF848_RS06540	COG0183	Belongs to the thiolase family
OF848_RS06545	COG1250	3-hydroxyacyl-CoA dehydrogenase
OF848_RS06545	COG1024	Enoyl-CoA hydratase
OF848_RS06560	COG5577	PFAM Coat F domain
OF848_RS06570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF848_RS06595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OF848_RS06605	COG0753	catalase activity
OF848_RS06610	COG0671	phosphoesterase, PA-phosphatase related
OF848_RS06620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OF848_RS06635	COG1595	DNA-templated transcription, initiation
OF848_RS06640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OF848_RS06655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OF848_RS06665	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
OF848_RS06670	COG1028	Short-chain dehydrogenase reductase Sdr
OF848_RS06675	COG2211	Major facilitator Superfamily
OF848_RS06685	COG2721	sulfolactate sulfo-lyase activity
OF848_RS06690	COG0246	Mannitol dehydrogenase
OF848_RS06700	COG0800	Aldolase
OF848_RS06720	COG0488	(ABC) transporter
OF848_RS06790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OF848_RS06795	COG0557	exoribonuclease II activity
OF848_RS06805	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OF848_RS06810	COG0148	phosphopyruvate hydratase activity
OF848_RS06815	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OF848_RS06825	COG0126	phosphoglycerate kinase activity
OF848_RS06845	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
OF848_RS06870	COG3383	formate dehydrogenase (NAD+) activity
OF848_RS06885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OF848_RS06900	COG4608	Belongs to the ABC transporter superfamily
OF848_RS06905	COG0791	NLP P60 protein
OF848_RS06910	COG4166	transmembrane transport
OF848_RS06915	COG0444	Belongs to the ABC transporter superfamily
OF848_RS06920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OF848_RS06925	COG0601	transmembrane transport
OF848_RS06930	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OF848_RS06935	COG0598	Magnesium transport protein CorA
OF848_RS06945	COG2719	SpoVR family
OF848_RS06950	COG3594	Acyltransferase
OF848_RS06975	COG1392	Phosphate transport regulator
OF848_RS06980	COG0306	phosphate transporter
OF848_RS06995	COG2718	Belongs to the UPF0229 family
OF848_RS07000	COG2766	serine protein kinase
OF848_RS07005	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OF848_RS07020	COG2095	MarC family integral membrane protein
OF848_RS07030	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
OF848_RS07035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OF848_RS07040	COG0765	amino acid transport
OF848_RS07050	COG2116	formate transmembrane transporter activity
OF848_RS07055	COG1882	Formate acetyltransferase
OF848_RS07060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OF848_RS07065	COG0431	NADPH-dependent FMN reductase
OF848_RS07080	COG1131	(ABC) transporter
OF848_RS07105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OF848_RS07215	COG3527	Alpha-acetolactate decarboxylase
OF848_RS07220	COG0028	Belongs to the TPP enzyme family
OF848_RS07225	COG0583	DNA-binding transcription factor activity
OF848_RS07230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OF848_RS07235	COG0735	belongs to the Fur family
OF848_RS07250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OF848_RS07260	COG4129	membrane
OF848_RS07265	COG1737	Transcriptional regulator
OF848_RS07270	COG1263	PTS System
OF848_RS07270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OF848_RS07275	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
OF848_RS07290	COG1132	(ABC) transporter
OF848_RS07295	COG3557	Belongs to the UPF0374 family
OF848_RS07310	COG1028	Short-chain dehydrogenase reductase Sdr
OF848_RS07315	COG0583	DNA-binding transcription factor activity
OF848_RS07320	COG0067	glutamate synthase
OF848_RS07320	COG0070	glutamate synthase
OF848_RS07320	COG0069	glutamate synthase activity
OF848_RS07325	COG0493	'glutamate synthase
OF848_RS07335	COG1988	membrane-bound metal-dependent
OF848_RS07350	COG2137	regulation of response to DNA damage stimulus
OF848_RS07365	COG0159	tryptophan synthase activity
OF848_RS07375	COG0133	tryptophan synthase activity
OF848_RS07380	COG0134	indole-3-glycerol-phosphate synthase activity
OF848_RS07385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OF848_RS07390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OF848_RS07390	COG0512	Glutamine amidotransferase of anthranilate synthase
OF848_RS07400	COG0577	efflux transmembrane transporter activity
OF848_RS07400	COG1136	(ABC) transporter
OF848_RS07405	COG0058	SHG alpha-glucan phosphorylase activity
OF848_RS07410	COG0840	transmembrane signaling receptor activity
OF848_RS07415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OF848_RS07420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OF848_RS07440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OF848_RS07445	COG0066	3-isopropylmalate dehydratase activity
OF848_RS07450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OF848_RS07460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OF848_RS07470	COG0440	acetolactate synthase activity
OF848_RS07475	COG0028	Belongs to the TPP enzyme family
OF848_RS07480	COG0129	dihydroxy-acid dehydratase activity
OF848_RS07485	COG1114	Component of the transport system for branched-chain amino acids
OF848_RS07490	COG1366	Belongs to the anti-sigma-factor antagonist family
OF848_RS07500	COG2124	cytochrome p450
OF848_RS07505	COG0670	Belongs to the BI1 family
OF848_RS07510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OF848_RS07520	COG3279	Response regulator of the LytR AlgR family
OF848_RS07525	COG3275	phosphorelay sensor kinase activity
OF848_RS07530	COG0252	asparaginase activity
OF848_RS07535	COG2132	Multicopper oxidase
OF848_RS07545	COG1511	domain protein
OF848_RS07585	COG3655	Transcriptional regulator
OF848_RS07600	COG1823	symporter activity
OF848_RS07605	COG2839	Protein conserved in bacteria
OF848_RS07625	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
OF848_RS07630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OF848_RS07635	COG1279	arginine transmembrane transporter activity
OF848_RS07655	COG1132	(ABC) transporter
OF848_RS07660	COG1846	Transcriptional regulator
OF848_RS07665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OF848_RS07670	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
OF848_RS07690	COG0387	Pfam Sodium calcium exchanger
OF848_RS07695	COG0477	Major facilitator Superfamily
OF848_RS07700	COG1295	ribonuclease BN
OF848_RS07705	COG4840	Belongs to the UPF0435 family
OF848_RS07715	COG0693	protein deglycase activity
OF848_RS07725	COG1360	Flagellar Motor Protein
OF848_RS07730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OF848_RS07745	COG3189	MarR family transcriptional regulator
OF848_RS07755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OF848_RS07760	COG1607	acyl-coa hydrolase
OF848_RS07765	COG1077	Cell shape determining protein MreB Mrl
OF848_RS07770	COG2268	Band 7 protein
OF848_RS07775	COG1585	Membrane protein implicated in regulation of membrane protease activity
OF848_RS07780	COG0626	cystathionine gamma-synthase activity
OF848_RS07785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OF848_RS07790	COG1854	S-ribosylhomocysteine lyase activity
OF848_RS07795	COG2226	methyltransferase
OF848_RS07800	COG0288	reversible hydration of carbon dioxide
OF848_RS07815	COG2197	response regulator
OF848_RS07835	COG4086	secreted protein
OF848_RS07845	COG1737	Transcriptional regulator
OF848_RS07850	COG0737	Belongs to the 5'-nucleotidase family
OF848_RS07870	COG3620	sequence-specific DNA binding
OF848_RS07880	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
OF848_RS07885	COG1518	maintenance of DNA repeat elements
OF848_RS07990	COG1304	FMN binding
OF848_RS07995	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
OF848_RS08000	COG0166	Belongs to the GPI family
OF848_RS08005	COG0025	NhaP-type Na H and K H
OF848_RS08010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF848_RS08010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OF848_RS08010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OF848_RS08015	COG1349	DNA-binding transcription factor activity
OF848_RS08020	COG0371	Dehydrogenase
OF848_RS08025	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
OF848_RS08035	COG0561	phosphatase activity
OF848_RS08050	COG2814	Major facilitator Superfamily
OF848_RS08055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
OF848_RS08080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OF848_RS08085	COG0531	amino acid
OF848_RS08090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OF848_RS08095	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
OF848_RS08105	COG2376	Dihydroxyacetone kinase
OF848_RS08175	COG0778	Nitroreductase
OF848_RS08180	COG1113	amino acid transport
OF848_RS08185	COG0730	response to heat
OF848_RS08190	COG2233	PERMEase
OF848_RS08195	COG0210	DNA helicase
OF848_RS08200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OF848_RS08215	COG1028	Short-chain dehydrogenase reductase Sdr
OF848_RS08220	COG1683	Conserved Protein
OF848_RS08245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OF848_RS08250	COG3829	transcription factor binding
OF848_RS08270	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
OF848_RS08275	COG0833	amino acid
OF848_RS08300	COG3588	fructose-bisphosphate aldolase
OF848_RS08335	COG0494	nUDIX hydrolase
OF848_RS08340	COG1715	Restriction endonuclease
OF848_RS08345	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
OF848_RS08370	COG1280	lysine exporter protein (LysE YggA)
OF848_RS08375	COG0386	Belongs to the glutathione peroxidase family
OF848_RS08380	COG2190	(PTS) system
OF848_RS08395	COG3403	YqcI/YcgG family
OF848_RS08400	COG0582	viral genome integration into host DNA
OF848_RS08430	COG1301	dicarboxylic acid transport
OF848_RS08445	COG1328	CTP reductase activity
OF848_RS08460	COG1929	Belongs to the glycerate kinase type-1 family
OF848_RS08480	COG4549	nuclear export factor GLE1
OF848_RS08485	COG2372	response to copper ion
OF848_RS08485	COG1276	copper resistance
OF848_RS08505	COG5002	protein histidine kinase activity
OF848_RS08510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OF848_RS08515	COG1278	Cold shock
OF848_RS08530	COG1472	Belongs to the glycosyl hydrolase 3 family
OF848_RS08540	COG3876	Protein conserved in bacteria
OF848_RS08545	COG1132	(ABC) transporter
OF848_RS08550	COG1132	(ABC) transporter
OF848_RS08560	COG1388	LysM domain
OF848_RS08560	COG0791	NLP P60 protein
OF848_RS08600	COG3153	acetyltransferase
OF848_RS08600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OF848_RS08605	COG5583	Uncharacterized small protein (DUF2292)
OF848_RS08610	COG0431	NADPH-dependent FMN reductase
OF848_RS08620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OF848_RS08625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OF848_RS08640	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OF848_RS08655	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
OF848_RS08665	COG2390	Transcriptional regulator
OF848_RS08675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OF848_RS08685	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
OF848_RS08700	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OF848_RS08705	COG1984	allophanate hydrolase subunit 2
OF848_RS08710	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OF848_RS08715	COG2814	Major facilitator Superfamily
OF848_RS08720	COG1764	response to oxidative stress
OF848_RS08725	COG1126	abc transporter atp-binding protein
OF848_RS08730	COG0765	amino acid transport
OF848_RS08735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OF848_RS08740	COG1473	amidohydrolase
OF848_RS08770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OF848_RS08785	COG1064	alcohol dehydrogenase
OF848_RS08795	COG5444	nuclease activity
OF848_RS08865	COG1401	restriction endodeoxyribonuclease activity
OF848_RS08965	COG2963	transposase activity
OF848_RS08995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OF848_RS09000	COG1597	lipid kinase activity
OF848_RS09020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OF848_RS09025	COG0154	amidase activity
OF848_RS09030	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OF848_RS09035	COG2224	Isocitrate lyase
OF848_RS09040	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OF848_RS09045	COG4851	CamS sex pheromone cAM373 precursor
OF848_RS09055	COG0210	DNA helicase
OF848_RS09060	COG3344	reverse transcriptase
OF848_RS09075	COG4496	protein, YerC YecD
OF848_RS09080	COG1470	cell adhesion involved in biofilm formation
OF848_RS09095	COG0151	Belongs to the GarS family
OF848_RS09100	COG0138	bifunctional purine biosynthesis protein purh
OF848_RS09105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OF848_RS09110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OF848_RS09115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
OF848_RS09120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OF848_RS09125	COG0047	phosphoribosylformylglycinamidine synthase activity
OF848_RS09130	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OF848_RS09140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OF848_RS09145	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OF848_RS09150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OF848_RS09160	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
OF848_RS09165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OF848_RS09210	COG1301	dicarboxylic acid transport
OF848_RS09220	COG3711	transcriptional antiterminator
OF848_RS09225	COG2252	PERMEase
OF848_RS09235	COG1132	(ABC) transporter
OF848_RS09240	COG2814	Major facilitator Superfamily
OF848_RS09260	COG0471	metal ion transport
OF848_RS09295	COG3328	transposase activity
OF848_RS09305	COG1131	(ABC) transporter
OF848_RS09310	COG1725	Transcriptional regulator
OF848_RS09315	COG1695	Transcriptional regulator
OF848_RS09320	COG3479	Phenolic acid decarboxylase
OF848_RS09325	COG2910	NAD(P)H-binding
OF848_RS09330	COG1959	2 iron, 2 sulfur cluster binding
OF848_RS09340	COG0535	radical SAM domain protein
OF848_RS09345	COG1994	Peptidase M50
OF848_RS09350	COG1131	(ABC) transporter
OF848_RS09365	COG4372	Transposase
OF848_RS09370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OF848_RS09385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OF848_RS09390	COG1279	arginine transmembrane transporter activity
OF848_RS09410	COG0425	Belongs to the sulfur carrier protein TusA family
OF848_RS09415	COG2391	methyltransferase activity
OF848_RS09425	COG1028	Short-chain dehydrogenase reductase Sdr
OF848_RS09445	COG1120	ATPase activity
OF848_RS09450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OF848_RS09485	COG3620	sequence-specific DNA binding
OF848_RS09505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OF848_RS09510	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
OF848_RS09515	COG1335	isochorismatase
OF848_RS09520	COG4948	Mandelate Racemase Muconate Lactonizing
OF848_RS09530	COG0463	Glycosyl transferase, family 2
OF848_RS09535	COG2246	polysaccharide biosynthetic process
OF848_RS09540	COG0459	protein refolding
OF848_RS09545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OF848_RS09550	COG1266	CAAX protease self-immunity
OF848_RS09565	COG0805	protein transport
OF848_RS09570	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
OF848_RS09575	COG0488	(ABC) transporter
OF848_RS09580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OF848_RS09585	COG0456	acetyltransferase
OF848_RS09590	COG1214	PFAM Peptidase M22, glycoprotease
OF848_RS09595	COG0802	atpase or kinase
OF848_RS09680	COG3091	SprT-like family
OF848_RS09690	COG2183	response to ionizing radiation
OF848_RS09695	COG2208	phosphoserine phosphatase activity
OF848_RS09700	COG1191	sigma factor activity
OF848_RS09705	COG2172	sigma factor antagonist activity
OF848_RS09710	COG1366	Belongs to the anti-sigma-factor antagonist family
OF848_RS09715	COG2208	phosphoserine phosphatase activity
OF848_RS09720	COG2172	sigma factor antagonist activity
OF848_RS09725	COG1366	Belongs to the anti-sigma-factor antagonist family
OF848_RS09730	COG1366	Belongs to the anti-sigma-factor antagonist family
OF848_RS09735	COG2337	Toxic component of a toxin-antitoxin (TA) module
OF848_RS09740	COG0864	Transcriptional regulator
OF848_RS09745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OF848_RS09750	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OF848_RS09755	COG0736	holo-[acyl-carrier-protein] synthase activity
OF848_RS09760	COG0705	Rhomboid family
OF848_RS09775	COG0513	Belongs to the DEAD box helicase family
OF848_RS09780	COG1280	lysine exporter protein (LysE YggA)
OF848_RS09790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OF848_RS09795	COG1609	Transcriptional regulator
OF848_RS09800	COG0366	Alpha amylase catalytic
OF848_RS09810	COG2182	Extracellular solute-binding protein
OF848_RS09815	COG1175	transmembrane transport
OF848_RS09820	COG3833	ABC-type maltose transport systems, permease component
OF848_RS09825	COG5521	maltodextrose utilization protein MalA
OF848_RS09830	COG1554	hydrolase, family 65, central catalytic
OF848_RS09840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OF848_RS09845	COG1181	Belongs to the D-alanine--D-alanine ligase family
OF848_RS09865	COG1253	flavin adenine dinucleotide binding
OF848_RS09870	COG0789	Transcriptional regulator
OF848_RS09875	COG1253	flavin adenine dinucleotide binding
OF848_RS09910	COG0629	single-stranded DNA binding
OF848_RS09920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OF848_RS09925	COG4786	Flagellar basal body rod
OF848_RS09930	COG4786	Flagellar basal body rod
OF848_RS09935	COG1077	Cell shape determining protein MreB Mrl
OF848_RS09940	COG1609	Transcriptional regulator
OF848_RS09945	COG0739	heme binding
OF848_RS09950	COG2385	sporulation resulting in formation of a cellular spore
OF848_RS09955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OF848_RS09965	COG4836	Membrane
OF848_RS09970	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OF848_RS09975	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OF848_RS09980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OF848_RS09985	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OF848_RS09990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OF848_RS10000	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OF848_RS10005	COG0356	it plays a direct role in the translocation of protons across the membrane
OF848_RS10015	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OF848_RS10020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OF848_RS10030	COG4475	Protein of unknown function (DUF436)
OF848_RS10035	COG0698	ribose 5-phosphate isomerase
OF848_RS10040	COG0840	transmembrane signaling receptor activity
OF848_RS10080	COG1971	Probably functions as a manganese efflux pump
OF848_RS10085	COG0009	L-threonylcarbamoyladenylate synthase
OF848_RS10100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OF848_RS10110	COG1435	thymidine kinase activity
OF848_RS10115	COG0254	rRNA binding
OF848_RS10120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OF848_RS10125	COG1494	fructose-1,6-bisphosphatase
OF848_RS10130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OF848_RS10135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OF848_RS10140	COG0191	fructose-bisphosphate aldolase activity
OF848_RS10145	COG2204	response regulator
OF848_RS10170	COG1131	(ABC) transporter
OF848_RS10175	COG1725	Transcriptional regulator
OF848_RS10180	COG0504	CTP synthase activity
OF848_RS10185	COG3343	RNA polymerase activity
OF848_RS10200	COG1309	transcriptional regulator
OF848_RS10205	COG1960	acyl-CoA dehydrogenase activity
OF848_RS10210	COG1960	acyl-CoA dehydrogenase activity
OF848_RS10215	COG0183	Belongs to the thiolase family
OF848_RS10220	COG0247	lactate metabolic process
OF848_RS10220	COG2181	nitrate reductase activity
OF848_RS10225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OF848_RS10230	COG0018	arginyl-trna synthetase
OF848_RS10240	COG0010	Belongs to the arginase family
OF848_RS10245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OF848_RS10255	COG1994	Peptidase M50
OF848_RS10265	COG3465	dGTPase activity
OF848_RS10270	COG1078	dGTPase activity
OF848_RS10280	COG0095	Lipoate-protein ligase
OF848_RS10290	COG0280	phosphate acetyltransferase
OF848_RS10295	COG3253	May function as heme-dependent peroxidase
OF848_RS10325	COG2363	Small membrane protein
OF848_RS10335	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
OF848_RS10360	COG3949	Membrane
OF848_RS10365	COG4948	Mandelate Racemase Muconate Lactonizing
OF848_RS10375	COG1473	amidohydrolase
OF848_RS10385	COG0351	phosphomethylpyrimidine kinase
OF848_RS10400	COG0561	phosphatase activity
OF848_RS10405	COG0514	ATP-dependent DNA helicase (RecQ)
OF848_RS10410	COG1785	Belongs to the alkaline phosphatase family
OF848_RS10415	COG1737	Transcriptional regulator
OF848_RS10430	COG3850	Histidine kinase
OF848_RS10430	COG5002	protein histidine kinase activity
OF848_RS10440	COG0745	RESPONSE REGULATOR receiver
OF848_RS10450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OF848_RS10460	COG1346	cytolysis
OF848_RS10465	COG1380	Effector of murein hydrolase LrgA
OF848_RS10470	COG0583	DNA-binding transcription factor activity
OF848_RS10475	COG0367	asparagine synthase
OF848_RS10550	COG2966	Psort location CytoplasmicMembrane, score
OF848_RS10555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OF848_RS10560	COG1966	Carbon starvation protein
OF848_RS10565	COG1464	Belongs to the NlpA lipoprotein family
OF848_RS10570	COG2011	ABC-type metal ion transport system permease component
OF848_RS10575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OF848_RS10580	COG1119	ATPase activity
OF848_RS10595	COG0534	Mate efflux family protein
OF848_RS10600	COG1442	glycosyl transferase family 8
OF848_RS10605	COG2195	Cleaves the N-terminal amino acid of tripeptides
OF848_RS10620	COG2814	Major facilitator Superfamily
OF848_RS10630	COG0028	Belongs to the TPP enzyme family
OF848_RS10675	COG0584	glycerophosphoryl diester phosphodiesterase
OF848_RS10700	COG1132	(ABC) transporter
OF848_RS10710	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OF848_RS10730	COG1366	Belongs to the anti-sigma-factor antagonist family
OF848_RS10765	COG1126	abc transporter atp-binding protein
OF848_RS10775	COG0765	amino acid transport
OF848_RS10800	COG0579	oxidoreductase
OF848_RS10880	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
OF848_RS10885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OF848_RS10890	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
OF848_RS10895	COG4853	Protein conserved in bacteria
OF848_RS10900	COG4863	YycH protein
OF848_RS10905	COG5002	protein histidine kinase activity
OF848_RS10910	COG0745	RESPONSE REGULATOR receiver
OF848_RS10925	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OF848_RS10930	COG0305	Participates in initiation and elongation during chromosome replication
OF848_RS10935	COG0359	binds to the 23S rRNA
OF848_RS10940	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
OF848_RS10950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OF848_RS10960	COG0360	Binds together with S18 to 16S ribosomal RNA
OF848_RS10965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OF848_RS10970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OF848_RS10970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OF848_RS10975	COG0307	riboflavin synthase, alpha
OF848_RS10980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OF848_RS10980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OF848_RS10985	COG0012	GTP binding
OF848_RS10990	COG4481	Protein conserved in bacteria
OF848_RS10995	COG0668	transmembrane transport
OF848_RS11005	COG1811	Na channel or pump
OF848_RS11010	COG1475	DNA binding
OF848_RS11015	COG1192	Involved in chromosome partitioning
OF848_RS11025	COG1475	DNA binding
OF848_RS11030	COG0357	Ribosomal RNA small subunit methyltransferase G
OF848_RS11035	COG0445	tRNA wobble uridine modification
OF848_RS11040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OF848_RS11045	COG1847	R3H domain protein
OF848_RS11050	COG0706	membrane insertase activity
OF848_RS11055	COG0594	ribonuclease P activity
OF848_RS11060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
OF848_RS11065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OF848_RS11070	COG0592	DNA-directed DNA polymerase activity
OF848_RS11080	COG2501	S4 domain
OF848_RS11085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OF848_RS11095	COG0187	DNA topoisomerase II activity
OF848_RS11100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OF848_RS11105	COG3437	response regulator, receiver
OF848_RS11140	COG1982	Orn Lys Arg decarboxylase major
OF848_RS11150	COG3870	Protein conserved in bacteria
OF848_RS11155	COG1728	Protein conserved in bacteria
OF848_RS11160	COG0470	DNA polymerase III
OF848_RS11165	COG1774	PSP1 C-terminal conserved region
OF848_RS11170	COG4467	Involved in initiation control of chromosome replication
OF848_RS11175	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
OF848_RS11180	COG2827	Endonuclease containing a URI domain
OF848_RS11185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
OF848_RS11200	COG0084	hydrolase, TatD family'
OF848_RS11220	COG4466	Protein conserved in bacteria
OF848_RS11230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OF848_RS11235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OF848_RS11240	COG0251	oxidation-reduction process
OF848_RS11250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OF848_RS11255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OF848_RS11260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
OF848_RS11280	COG2002	toxin-antitoxin pair type II binding
OF848_RS11285	COG2244	polysaccharide biosynthetic process
OF848_RS11290	COG3956	TIGRFAM MazG family protein
OF848_RS11295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OF848_RS11315	COG1098	S1 RNA binding domain
OF848_RS11325	COG2208	phosphoserine phosphatase activity
OF848_RS11330	COG2304	oxidoreductase activity
OF848_RS11335	COG0515	serine threonine protein kinase
OF848_RS11340	COG0037	tRNA processing
OF848_RS11345	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
OF848_RS11350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OF848_RS11360	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
OF848_RS11365	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OF848_RS11370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OF848_RS11375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OF848_RS11380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OF848_RS11385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OF848_RS11465	COG0517	IMP dehydrogenase activity
OF848_RS11465	COG0516	GMP reductase activity
OF848_RS11480	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
OF848_RS11485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OF848_RS11495	COG1428	Deoxynucleoside kinase
OF848_RS11500	COG1428	Deoxynucleoside kinase
OF848_RS11515	COG0590	tRNA wobble adenosine to inosine editing
OF848_RS11525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OF848_RS11530	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OF848_RS11535	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OF848_RS11580	COG3880	PFAM UvrB UvrC protein
OF848_RS11585	COG3869	Catalyzes the specific phosphorylation of arginine residues in
OF848_RS11590	COG0542	response to heat
OF848_RS11595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
OF848_RS11600	COG4956	integral membrane protein (PIN domain superfamily)
OF848_RS11610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OF848_RS11615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OF848_RS11625	COG0215	cysteine-tRNA ligase activity
OF848_RS11635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OF848_RS11660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OF848_RS11665	COG0250	Participates in transcription elongation, termination and antitermination
OF848_RS11670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OF848_RS11675	COG0081	regulation of translation
OF848_RS11680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OF848_RS11690	COG2813	Specifically methylates the guanine in position
OF848_RS11695	COG0085	RNA polymerase activity
OF848_RS11700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OF848_RS11705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OF848_RS11710	COG1358	cellular component organization or biogenesis
OF848_RS11715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OF848_RS11720	COG0049	tRNA binding
OF848_RS11725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OF848_RS11730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OF848_RS11735	COG0051	transcription antitermination factor activity, RNA binding
OF848_RS11755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OF848_RS11760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OF848_RS11770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OF848_RS11775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OF848_RS11780	COG0255	Belongs to the universal ribosomal protein uL29 family
OF848_RS11790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OF848_RS11800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OF848_RS11805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OF848_RS11810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OF848_RS11815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OF848_RS11820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OF848_RS11825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OF848_RS11835	COG0200	Binds to the 23S rRNA
OF848_RS11840	COG0201	protein transport
OF848_RS11845	COG0563	adenylate kinase activity
OF848_RS11850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OF848_RS11855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OF848_RS11860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OF848_RS11865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OF848_RS11870	COG0202	RNA polymerase activity
OF848_RS11875	COG0203	ribosomal protein L17
OF848_RS11880	COG1122	ATPase activity
OF848_RS11885	COG1122	ATPase activity
OF848_RS11890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
OF848_RS11900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OF848_RS11905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OF848_RS11915	COG2046	Belongs to the sulfate adenylyltransferase family
OF848_RS11920	COG0529	Catalyzes the synthesis of activated sulfate
OF848_RS11925	COG0833	amino acid
OF848_RS11935	COG0860	N-Acetylmuramoyl-L-alanine amidase
OF848_RS11940	COG0489	protein tyrosine kinase activity
OF848_RS11950	COG2194	sulfuric ester hydrolase activity
OF848_RS11965	COG0662	Cupin 2, conserved barrel domain protein
OF848_RS11990	COG0726	polysaccharide deacetylase
OF848_RS12000	COG1271	oxidase subunit
OF848_RS12005	COG1294	oxidase, subunit
OF848_RS12010	COG4988	ABC transporter
OF848_RS12015	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
OF848_RS12085	COG1525	nuclease
OF848_RS12110	COG3617	BRO family, N-terminal domain
OF848_RS12150	COG5377	YqaJ viral recombinase family
OF848_RS12155	COG3723	Recombinational DNA repair protein, rece pathway
OF848_RS12240	COG0175	sulfate reduction
OF848_RS12250	COG3677	Transposase
OF848_RS12260	COG5484	DNA packaging
OF848_RS12440	COG1525	nuclease
OF848_RS12465	COG3617	BRO family, N-terminal domain
OF848_RS12505	COG5377	YqaJ viral recombinase family
OF848_RS12510	COG3723	Recombinational DNA repair protein, rece pathway
OF848_RS12605	COG0175	sulfate reduction
OF848_RS12615	COG3677	Transposase
OF848_RS12625	COG5484	DNA packaging
OF848_RS12815	COG5662	AntiSigma factor
OF848_RS12830	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
OF848_RS12835	COG4856	YbbR-like protein
OF848_RS12840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OF848_RS12850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OF848_RS12865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OF848_RS12910	COG3425	synthase
OF848_RS12915	COG0183	Belongs to the thiolase family
OF848_RS12935	COG0517	IMP dehydrogenase activity
OF848_RS12935	COG1125	glycine betaine transport
OF848_RS12940	COG1174	glycine betaine transport
OF848_RS12945	COG2190	(PTS) system
OF848_RS12950	COG1263	PTS System
OF848_RS12950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OF848_RS12955	COG0366	Alpha amylase catalytic
OF848_RS12960	COG2188	Transcriptional regulator
OF848_RS12970	COG1070	Carbohydrate kinase
OF848_RS12980	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
OF848_RS12985	COG0716	FMN binding
OF848_RS12990	COG0322	excinuclease ABC activity
OF848_RS12995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OF848_RS13000	COG2217	Heavy metal translocating P-type atpase
OF848_RS13005	COG2217	Heavy metal translocating P-type atpase
OF848_RS13015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OF848_RS13025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OF848_RS13030	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OF848_RS13035	COG1215	transferase activity, transferring glycosyl groups
OF848_RS13050	COG2076	Multidrug Resistance protein
OF848_RS13055	COG2076	Multidrug Resistance protein
OF848_RS13065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OF848_RS13070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OF848_RS13075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OF848_RS13080	COG1120	ATPase activity
OF848_RS13100	COG0217	transcriptional regulatory protein
OF848_RS13105	COG1366	Belongs to the anti-sigma-factor antagonist family
OF848_RS13110	COG1960	acyl-CoA dehydrogenase activity
OF848_RS13115	COG1028	Short-chain dehydrogenase reductase Sdr
OF848_RS13125	COG1309	transcriptional regulator
OF848_RS13205	COG3226	Transcriptional regulator
OF848_RS13220	COG1012	belongs to the aldehyde dehydrogenase family
OF848_RS13230	COG5434	Belongs to the glycosyl hydrolase 28 family
OF848_RS13240	COG0175	sulfate reduction
OF848_RS13260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OF848_RS13270	COG0371	Dehydrogenase
OF848_RS13285	COG0318	PFAM AMP-dependent synthetase and ligase
OF848_RS13300	COG0697	spore germination
OF848_RS13320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OF848_RS13325	COG1442	glycosyl transferase family 8
OF848_RS13325	COG1216	Glycosyl transferase, family 2
OF848_RS13330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
OF848_RS13345	COG0702	epimerase
OF848_RS13360	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
OF848_RS13380	COG2848	UPF0210 protein
OF848_RS13395	COG1609	Transcriptional regulator
OF848_RS13400	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OF848_RS13405	COG5577	PFAM Coat F domain
OF848_RS13410	COG0667	Aldo Keto reductase
OF848_RS13420	COG1113	amino acid transport
OF848_RS13430	COG3104	oligopeptide transport
OF848_RS13435	COG0833	amino acid
OF848_RS13445	COG3842	ATPase activity
OF848_RS13450	COG1176	ABC-type spermidine putrescine transport system, permease component I
OF848_RS13455	COG1177	transmembrane transport
OF848_RS13470	COG0531	amino acid
OF848_RS13475	COG1556	Lactate utilization protein
OF848_RS13480	COG1139	Iron-sulfur cluster binding protein
OF848_RS13485	COG0247	lactate metabolic process
OF848_RS13490	COG0531	amino acid
OF848_RS13495	COG1979	alcohol dehydrogenase
OF848_RS13500	COG0004	ammonium transporteR
OF848_RS13505	COG3290	protein histidine kinase activity
OF848_RS13510	COG4565	transcriptional regulatory protein
OF848_RS13515	COG2851	Citrate transporter
OF848_RS13520	COG0463	Glycosyl transferase, family 2
OF848_RS13525	COG3973	AAA domain
OF848_RS13570	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
OF848_RS13575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OF848_RS13580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OF848_RS13585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OF848_RS13590	COG1301	dicarboxylic acid transport
OF848_RS13595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OF848_RS13620	COG1902	pentaerythritol trinitrate reductase activity
OF848_RS13635	COG0423	glycine-tRNA ligase activity
OF848_RS13640	COG0531	amino acid
OF848_RS13650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OF848_RS13655	COG0628	permease
OF848_RS13670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OF848_RS13675	COG0765	amino acid transport
OF848_RS13680	COG0765	amino acid transport
OF848_RS13695	COG1733	regulation of RNA biosynthetic process
OF848_RS13705	COG0586	Pfam SNARE associated Golgi protein
OF848_RS13710	COG0586	Pfam SNARE associated Golgi protein
OF848_RS13725	COG0646	methionine synthase
OF848_RS13725	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OF848_RS13730	COG0646	methionine synthase
OF848_RS13730	COG1410	methionine synthase
OF848_RS13755	COG3944	biosynthesis protein
OF848_RS13760	COG0489	protein tyrosine kinase activity
OF848_RS13765	COG4464	protein tyrosine phosphatase activity
OF848_RS13770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OF848_RS13775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OF848_RS13790	COG1442	glycosyl transferase family 8
OF848_RS13790	COG1216	Glycosyl transferase, family 2
OF848_RS13795	COG1442	glycosyl transferase family 8
OF848_RS13795	COG1216	Glycosyl transferase, family 2
OF848_RS13875	COG1070	Carbohydrate kinase
OF848_RS13880	COG1063	alcohol dehydrogenase
OF848_RS13885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OF848_RS13895	COG4193	domain, Protein
OF848_RS13900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OF848_RS13915	COG5504	Zn-dependent protease
OF848_RS13935	COG2226	methyltransferase
OF848_RS13940	COG0366	Alpha amylase catalytic
OF848_RS13940	COG5263	repeat protein
OF848_RS13965	COG2315	Protein conserved in bacteria
OF848_RS13975	COG2333	competence protein COMEC
OF848_RS13975	COG0658	competence protein
OF848_RS14025	COG0531	amino acid
OF848_RS14035	COG1316	TRANSCRIPTIONal
OF848_RS14045	COG4989	oxidoreductase activity
OF848_RS14065	COG2130	NADP-dependent
OF848_RS14095	COG2190	(PTS) system
OF848_RS14095	COG2211	Major facilitator Superfamily
OF848_RS14110	COG2814	Major facilitator Superfamily
OF848_RS14135	COG2814	Major facilitator Superfamily
OF848_RS14140	COG1609	Transcriptional regulator
OF848_RS14160	COG1174	glycine betaine transport
OF848_RS14165	COG1732	Glycine betaine
OF848_RS14170	COG1174	glycine betaine transport
OF848_RS14175	COG0517	IMP dehydrogenase activity
OF848_RS14175	COG1125	glycine betaine transport
OF848_RS14180	COG1510	regulation of RNA biosynthetic process
OF848_RS14185	COG0110	maltose O-acetyltransferase activity
OF848_RS14200	COG4297	protein containing double-stranded beta helix domain
OF848_RS14210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OF848_RS14215	COG2272	Belongs to the type-B carboxylesterase lipase family
OF848_RS14220	COG0606	chelatase, subunit chli
OF848_RS14235	COG0371	Dehydrogenase
OF848_RS14245	COG0157	Belongs to the NadC ModD family
OF848_RS14250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
OF848_RS14255	COG1104	cysteine desulfurase activity
OF848_RS14275	COG1131	(ABC) transporter
OF848_RS14305	COG4720	Psort location CytoplasmicMembrane, score
OF848_RS14340	COG0584	glycerophosphoryl diester phosphodiesterase
OF848_RS14390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OF848_RS14395	COG0737	Belongs to the 5'-nucleotidase family
OF848_RS14400	COG1363	Peptidase, m42
OF848_RS14420	COG1620	l-lactate permease
OF848_RS14425	COG2186	Transcriptional regulator
OF848_RS14475	COG1447	Phosphotransferase system cellobiose-specific component IIA
OF848_RS14500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OF848_RS14500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OF848_RS14505	COG2723	6-phospho-beta-galactosidase activity
OF848_RS14515	COG3711	transcriptional antiterminator
OF848_RS14515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF848_RS14520	COG2877	3-deoxy-8-phosphooctulonate synthase activity
OF848_RS14555	COG1653	transport
OF848_RS14560	COG2207	Transcriptional regulator
OF848_RS14575	COG0604	alcohol dehydrogenase
OF848_RS14580	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
OF848_RS14585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OF848_RS14610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OF848_RS14630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OF848_RS14635	COG1316	TRANSCRIPTIONal
OF848_RS14645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OF848_RS14650	COG1554	hydrolase, family 65, central catalytic
OF848_RS14660	COG1609	Transcriptional regulator
OF848_RS14665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OF848_RS14680	COG3584	3D domain protein
OF848_RS14680	COG1388	LysM domain
OF848_RS14690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OF848_RS14700	COG1511	domain protein
OF848_RS14710	COG0011	TIGRFAM Protein of
OF848_RS14715	COG2706	6-phosphogluconolactonase activity
OF848_RS14725	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
OF848_RS14725	COG3933	PFAM sigma-54 factor interaction domain-containing protein
OF848_RS14730	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF848_RS14730	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OF848_RS14740	COG3715	PTS system
OF848_RS14745	COG3716	PTS system mannose fructose sorbose family IID component
OF848_RS14760	COG2079	MmgE PrpD family protein
OF848_RS14765	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OF848_RS14775	COG0154	amidase activity
OF848_RS14785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OF848_RS14790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OF848_RS14795	COG1116	anion transmembrane transporter activity
OF848_RS14800	COG0083	homoserine kinase activity
OF848_RS14805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OF848_RS14810	COG0460	homoserine dehydrogenase
OF848_RS14815	COG0010	Belongs to the arginase family
OF848_RS14825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OF848_RS14830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OF848_RS14840	COG4145	pantothenate transmembrane transporter activity
OF848_RS14855	COG1012	belongs to the aldehyde dehydrogenase family
OF848_RS14855	COG1454	alcohol dehydrogenase
OF848_RS14870	COG1388	LysM domain
OF848_RS14870	COG0791	NLP P60 protein
OF848_RS14875	COG0024	Methionine aminopeptidase
OF848_RS14880	COG1268	BioY protein
OF848_RS14905	COG2323	membrane
OF848_RS14915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OF848_RS14925	COG1028	Short-chain dehydrogenase reductase Sdr
OF848_RS14930	COG2746	aminoglycoside 3-N-acetyltransferase activity
OF848_RS14935	COG2244	polysaccharide biosynthetic process
OF848_RS14940	COG0589	response to stress
OF848_RS14965	COG0561	phosphatase activity
OF848_RS14990	COG0431	NADPH-dependent FMN reductase
OF848_RS15005	COG0420	3'-5' exonuclease activity
OF848_RS15010	COG4717	serine-type aminopeptidase activity
OF848_RS15020	COG1250	3-hydroxyacyl-CoA dehydrogenase
OF848_RS15025	COG0534	Mate efflux family protein
OF848_RS15030	COG0789	Transcriptional regulator
OF848_RS15035	COG0436	Aminotransferase
OF848_RS15040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OF848_RS15050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OF848_RS15100	COG2226	methyltransferase
OF848_RS15110	COG1090	epimerase
OF848_RS15115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OF848_RS15130	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
OF848_RS15145	COG1960	acyl-CoA dehydrogenase activity
OF848_RS15160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OF848_RS15165	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
OF848_RS15170	COG2017	converts alpha-aldose to the beta-anomer
OF848_RS15175	COG1609	Transcriptional regulator
OF848_RS15200	COG2996	Protein conserved in bacteria
OF848_RS15205	COG0346	lactoylglutathione lyase activity
OF848_RS15210	COG1482	cell wall glycoprotein biosynthetic process
OF848_RS15220	COG0477	Major facilitator Superfamily
OF848_RS15225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OF848_RS15235	COG2188	Transcriptional regulator
OF848_RS15240	COG1388	LysM domain
OF848_RS15240	COG0791	NLP P60 protein
OF848_RS15250	COG0768	penicillin binding
OF848_RS15255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OF848_RS15270	COG2197	response regulator
OF848_RS15275	COG0531	amino acid
OF848_RS15280	COG1307	EDD domain protein, DegV family
OF848_RS15285	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
OF848_RS15290	COG1040	competence protein
OF848_RS15300	COG2747	anti-sigma28 factor FlgM
OF848_RS15310	COG1256	bacterial-type flagellum assembly
OF848_RS15310	COG4786	Flagellar basal body rod
OF848_RS15315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OF848_RS15325	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
OF848_RS15350	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
OF848_RS15355	COG1285	pathogenesis
OF848_RS15360	COG0647	UMP catabolic process
OF848_RS15370	COG2271	Major facilitator Superfamily
OF848_RS15380	COG1113	amino acid transport
OF848_RS15385	COG1067	ATP-dependent peptidase activity
OF848_RS15440	COG2094	Belongs to the DNA glycosylase MPG family
OF848_RS15450	COG1334	flagellar protein FlaG
OF848_RS15455	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
OF848_RS15460	COG1516	flagellar protein fliS
OF848_RS15475	COG0405	Gamma-glutamyltransferase
OF848_RS15495	COG0653	protein targeting
OF848_RS15505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OF848_RS15515	COG2884	Cell division ATP-binding protein ftsE
OF848_RS15520	COG2177	Part of the ABC transporter FtsEX involved in
OF848_RS15525	COG0739	heme binding
OF848_RS15540	COG0460	homoserine dehydrogenase
OF848_RS15545	COG0793	Belongs to the peptidase S41A family
OF848_RS15545	COG3409	Peptidoglycan-binding domain 1 protein
OF848_RS15550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OF848_RS15555	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OF848_RS15560	COG4605	iron ion homeostasis
OF848_RS15565	COG4604	ABC transporter, ATP-binding protein
OF848_RS15570	COG4607	ABC-type enterochelin transport system periplasmic component
OF848_RS15590	COG0745	RESPONSE REGULATOR receiver
OF848_RS15595	COG5002	protein histidine kinase activity
OF848_RS15600	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
OF848_RS15610	COG0573	inorganic phosphate transmembrane transporter activity
OF848_RS15615	COG0581	inorganic phosphate transmembrane transporter activity
OF848_RS15620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OF848_RS15625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OF848_RS15650	COG0556	nucleotide-excision repair
OF848_RS15655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OF848_RS15660	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
OF848_RS15670	COG0463	Glycosyl transferase, family 2
OF848_RS15690	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
OF848_RS15725	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
OF848_RS15730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
OF848_RS15740	COG1682	transport, permease protein
OF848_RS15750	COG3595	metallopeptidase activity
OF848_RS15760	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
OF848_RS15770	COG0546	phosphoglycolate phosphatase activity
OF848_RS15775	COG0110	maltose O-acetyltransferase activity
OF848_RS15780	COG0457	Tetratricopeptide repeat
OF848_RS15785	COG0492	ferredoxin-NADP+ reductase activity
OF848_RS15790	COG1051	belongs to the nudix hydrolase family
OF848_RS15795	COG1660	Displays ATPase and GTPase activities
OF848_RS15800	COG0391	Required for morphogenesis under gluconeogenic growth conditions
OF848_RS15810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF848_RS15850	COG3842	ATPase activity
OF848_RS15855	COG2508	Transcriptional regulator
OF848_RS15865	COG0189	ligase activity
OF848_RS15870	COG0189	ligase activity
OF848_RS15880	COG4399	Belongs to the UPF0754 family
OF848_RS15890	COG0561	phosphatase activity
OF848_RS15895	COG1024	Enoyl-CoA hydratase
OF848_RS15905	COG0861	Integral membrane protein TerC family
OF848_RS15915	COG3689	TIGRFAM TIGR03943 family protein
OF848_RS15920	COG0420	3'-5' exonuclease activity
OF848_RS15925	COG4717	serine-type aminopeptidase activity
OF848_RS15930	COG3481	metal-dependent phosphohydrolase, HD sub domain
OF848_RS15940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OF848_RS15955	COG1846	Transcriptional regulator
OF848_RS15975	COG0537	adenosine 5'-monophosphoramidase activity
OF848_RS15980	COG1131	(ABC) transporter
OF848_RS15985	COG4473	ABC transporter
OF848_RS15995	COG1473	amidohydrolase
OF848_RS16000	COG3069	C4-dicarboxylate transmembrane transporter activity
OF848_RS16005	COG2329	Antibiotic biosynthesis monooxygenase
OF848_RS16010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OF848_RS16015	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OF848_RS16020	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
OF848_RS16025	COG1309	transcriptional regulator
OF848_RS16030	COG1511	domain protein
OF848_RS16035	COG2814	Major facilitator Superfamily
OF848_RS16040	COG0697	spore germination
OF848_RS16050	COG1999	signal sequence binding
OF848_RS16070	COG0318	PFAM AMP-dependent synthetase and ligase
OF848_RS16075	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OF848_RS16085	COG0501	Belongs to the peptidase M48B family
OF848_RS16095	COG4903	ComK protein
OF848_RS16105	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
OF848_RS16110	COG1074	ATP-dependent DNA helicase activity
OF848_RS16145	COG2311	Membrane
OF848_RS16150	COG0179	Fumarylacetoacetate (FAA) hydrolase
OF848_RS16170	COG1307	EDD domain protein, DegV family
OF848_RS16180	COG0561	phosphatase activity
OF848_RS16185	COG2151	metal-sulfur cluster biosynthetic enzyme
OF848_RS16220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OF848_RS16225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OF848_RS16240	COG4608	Belongs to the ABC transporter superfamily
OF848_RS16245	COG0601	transmembrane transport
OF848_RS16265	COG0180	Tryptophanyl-tRNA synthetase
OF848_RS16280	COG4166	transmembrane transport
OF848_RS16285	COG0601	transmembrane transport
OF848_RS16290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OF848_RS16295	COG0444	Belongs to the ABC transporter superfamily
OF848_RS16300	COG4608	Belongs to the ABC transporter superfamily
OF848_RS16305	COG1393	Belongs to the ArsC family
OF848_RS16310	COG4862	establishment of competence for transformation
OF848_RS16315	COG4469	Competence protein
OF848_RS16320	COG1164	Oligoendopeptidase f
OF848_RS16330	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OF848_RS16335	COG2346	COG2346, Truncated hemoglobins
OF848_RS16340	COG0741	lytic transglycosylase activity
OF848_RS16345	COG4116	CYTH
OF848_RS16355	COG2357	RelA SpoT domain protein
OF848_RS16365	COG0564	pseudouridine synthase activity
OF848_RS16370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OF848_RS16375	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OF848_RS16410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OF848_RS16435	COG2153	protein acetylation
OF848_RS16445	COG2382	esterase
OF848_RS16465	COG1940	carbohydrate kinase activity
OF848_RS16475	COG4152	abc transporter atp-binding protein
OF848_RS16480	COG1668	transmembrane transport
OF848_RS16490	COG3579	cysteine-type endopeptidase activity
OF848_RS16505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OF848_RS16510	COG2059	Chromate
OF848_RS16515	COG2059	Chromate
OF848_RS16520	COG1522	sequence-specific DNA binding
OF848_RS16545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OF848_RS16550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OF848_RS16585	COG2323	membrane
OF848_RS16635	COG0477	Major facilitator Superfamily
OF848_RS16645	COG1959	2 iron, 2 sulfur cluster binding
OF848_RS16655	COG0730	response to heat
OF848_RS16660	COG0783	Belongs to the Dps family
OF848_RS16670	COG3852	Histidine kinase
OF848_RS16675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OF848_RS16685	COG0861	Integral membrane protein TerC family
OF848_RS16700	COG5002	protein histidine kinase activity
OF848_RS16705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OF848_RS16720	COG0542	response to heat
OF848_RS16725	COG3949	Membrane
OF848_RS16745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF848_RS16760	COG2084	Dehydrogenase
OF848_RS16765	COG0436	Aminotransferase
OF848_RS16770	COG0784	Response regulator, receiver
OF848_RS16770	COG0835	chemotaxis
OF848_RS16780	COG1033	growth of symbiont in host cell
OF848_RS16780	COG2409	Drug exporters of the RND superfamily
OF848_RS16800	COG1028	Short-chain dehydrogenase reductase Sdr
OF848_RS16810	COG4703	Protein of unknown function (DUF1797)
OF848_RS16815	COG0517	IMP dehydrogenase activity