locus-tag	class	description
HYE74_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HYE74_RS00010	COG0592	DNA-directed DNA polymerase activity
HYE74_RS00015	COG2501	S4 domain
HYE74_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYE74_RS00030	COG0187	DNA topoisomerase II activity
HYE74_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYE74_RS00040	COG3437	response regulator, receiver
HYE74_RS00075	COG1982	Orn Lys Arg decarboxylase major
HYE74_RS00085	COG3870	Protein conserved in bacteria
HYE74_RS00090	COG1728	Protein conserved in bacteria
HYE74_RS00095	COG0470	DNA polymerase III
HYE74_RS00100	COG1774	PSP1 C-terminal conserved region
HYE74_RS00105	COG4467	Involved in initiation control of chromosome replication
HYE74_RS00110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HYE74_RS00115	COG2827	Endonuclease containing a URI domain
HYE74_RS00120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HYE74_RS00125	COG2002	toxin-antitoxin pair type II binding
HYE74_RS00135	COG0084	hydrolase, TatD family'
HYE74_RS00145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYE74_RS00155	COG4466	Protein conserved in bacteria
HYE74_RS00165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HYE74_RS00170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYE74_RS00175	COG0251	oxidation-reduction process
HYE74_RS00200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HYE74_RS00205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYE74_RS00210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HYE74_RS00215	COG0193	aminoacyl-tRNA hydrolase activity
HYE74_RS00225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HYE74_RS00230	COG2002	toxin-antitoxin pair type II binding
HYE74_RS00235	COG2244	polysaccharide biosynthetic process
HYE74_RS00240	COG3956	TIGRFAM MazG family protein
HYE74_RS00245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HYE74_RS00265	COG1098	S1 RNA binding domain
HYE74_RS00275	COG2208	phosphoserine phosphatase activity
HYE74_RS00280	COG2304	oxidoreductase activity
HYE74_RS00285	COG0515	serine threonine protein kinase
HYE74_RS00290	COG0037	tRNA processing
HYE74_RS00295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HYE74_RS00300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYE74_RS00305	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HYE74_RS00315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYE74_RS00320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HYE74_RS00325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HYE74_RS00330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HYE74_RS00410	COG0517	IMP dehydrogenase activity
HYE74_RS00410	COG0516	GMP reductase activity
HYE74_RS00425	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HYE74_RS00430	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HYE74_RS00440	COG1428	Deoxynucleoside kinase
HYE74_RS00445	COG1428	Deoxynucleoside kinase
HYE74_RS00450	COG3858	chitin binding
HYE74_RS00450	COG1388	LysM domain
HYE74_RS00455	COG0590	tRNA wobble adenosine to inosine editing
HYE74_RS00465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYE74_RS00470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HYE74_RS00475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYE74_RS00525	COG3880	PFAM UvrB UvrC protein
HYE74_RS00530	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HYE74_RS00535	COG0542	response to heat
HYE74_RS00540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HYE74_RS00545	COG4956	integral membrane protein (PIN domain superfamily)
HYE74_RS00555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HYE74_RS00560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYE74_RS00565	COG1045	serine acetyltransferase
HYE74_RS00570	COG0215	cysteine-tRNA ligase activity
HYE74_RS00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYE74_RS00585	COG3688	RNA-binding protein containing a PIN domain
HYE74_RS00595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYE74_RS00600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYE74_RS00605	COG0250	Participates in transcription elongation, termination and antitermination
HYE74_RS00610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HYE74_RS00615	COG0081	regulation of translation
HYE74_RS00620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HYE74_RS00625	COG0222	ribosome binding
HYE74_RS00630	COG2813	Specifically methylates the guanine in position
HYE74_RS00645	COG1358	cellular component organization or biogenesis
HYE74_RS00650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HYE74_RS00655	COG0049	tRNA binding
HYE74_RS00660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HYE74_RS00665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HYE74_RS00670	COG0051	transcription antitermination factor activity, RNA binding
HYE74_RS00680	COG0088	Forms part of the polypeptide exit tunnel
HYE74_RS00685	COG0089	rRNA binding
HYE74_RS00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HYE74_RS00695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HYE74_RS00705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HYE74_RS00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HYE74_RS00715	COG0255	Belongs to the universal ribosomal protein uL29 family
HYE74_RS00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HYE74_RS00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HYE74_RS00730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HYE74_RS00740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYE74_RS00745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HYE74_RS00750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HYE74_RS00755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HYE74_RS00760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HYE74_RS00770	COG0200	Binds to the 23S rRNA
HYE74_RS00775	COG0201	protein transport
HYE74_RS00780	COG0563	adenylate kinase activity
HYE74_RS00785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HYE74_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HYE74_RS00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HYE74_RS00800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HYE74_RS00805	COG0202	RNA polymerase activity
HYE74_RS00810	COG0203	ribosomal protein L17
HYE74_RS00815	COG1122	ATPase activity
HYE74_RS00820	COG1122	ATPase activity
HYE74_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HYE74_RS00835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HYE74_RS00840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HYE74_RS00845	COG0753	catalase activity
HYE74_RS00855	COG2046	Belongs to the sulfate adenylyltransferase family
HYE74_RS00860	COG0529	Catalyzes the synthesis of activated sulfate
HYE74_RS00865	COG0833	amino acid
HYE74_RS00875	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYE74_RS00880	COG0489	protein tyrosine kinase activity
HYE74_RS00890	COG2194	sulfuric ester hydrolase activity
HYE74_RS00915	COG0726	polysaccharide deacetylase
HYE74_RS00925	COG1271	oxidase subunit
HYE74_RS00930	COG1294	oxidase, subunit
HYE74_RS00935	COG4988	ABC transporter
HYE74_RS00940	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HYE74_RS00945	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS01020	COG1595	DNA-templated transcription, initiation
HYE74_RS01025	COG5662	AntiSigma factor
HYE74_RS01030	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HYE74_RS01035	COG4856	YbbR-like protein
HYE74_RS01040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYE74_RS01045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYE74_RS01075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HYE74_RS01080	COG0840	transmembrane signaling receptor activity
HYE74_RS01095	COG1695	Transcriptional regulator
HYE74_RS01100	COG0840	transmembrane signaling receptor activity
HYE74_RS01105	COG0477	Major facilitator Superfamily
HYE74_RS01155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYE74_RS01160	COG2814	Major facilitator Superfamily
HYE74_RS01180	COG0519	Catalyzes the synthesis of GMP from XMP
HYE74_RS01195	COG0477	Major facilitator Superfamily
HYE74_RS01195	COG2814	Major facilitator Superfamily
HYE74_RS01230	COG3425	synthase
HYE74_RS01235	COG0183	Belongs to the thiolase family
HYE74_RS01240	COG0183	Belongs to the thiolase family
HYE74_RS01245	COG0183	Belongs to the thiolase family
HYE74_RS01270	COG0517	IMP dehydrogenase activity
HYE74_RS01270	COG1125	glycine betaine transport
HYE74_RS01275	COG1174	glycine betaine transport
HYE74_RS01280	COG2190	(PTS) system
HYE74_RS01285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYE74_RS01285	COG1263	PTS System
HYE74_RS01290	COG0366	Alpha amylase catalytic
HYE74_RS01295	COG2188	Transcriptional regulator
HYE74_RS01305	COG1070	Carbohydrate kinase
HYE74_RS01315	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HYE74_RS01320	COG0716	FMN binding
HYE74_RS01325	COG0322	excinuclease ABC activity
HYE74_RS01335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYE74_RS01345	COG2217	Heavy metal translocating P-type atpase
HYE74_RS01350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYE74_RS01360	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYE74_RS01365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HYE74_RS01370	COG0463	Glycosyl transferase, family 2
HYE74_RS01390	COG2076	Multidrug Resistance protein
HYE74_RS01395	COG2076	Multidrug Resistance protein
HYE74_RS01405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYE74_RS01410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYE74_RS01415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HYE74_RS01420	COG1120	ATPase activity
HYE74_RS01445	COG0217	transcriptional regulatory protein
HYE74_RS01450	COG1366	Belongs to the anti-sigma-factor antagonist family
HYE74_RS01460	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS01470	COG1309	transcriptional regulator
HYE74_RS01490	COG1012	belongs to the aldehyde dehydrogenase family
HYE74_RS01495	COG5434	Belongs to the glycosyl hydrolase 28 family
HYE74_RS01505	COG0175	sulfate reduction
HYE74_RS01525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HYE74_RS01530	COG0371	Dehydrogenase
HYE74_RS01535	COG0318	PFAM AMP-dependent synthetase and ligase
HYE74_RS01550	COG0697	spore germination
HYE74_RS01570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYE74_RS01580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HYE74_RS01600	COG0702	epimerase
HYE74_RS01615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYE74_RS01620	COG0765	amino acid transport
HYE74_RS01625	COG1126	abc transporter atp-binding protein
HYE74_RS01630	COG2222	sugar isomerase
HYE74_RS01635	COG2188	Transcriptional regulator
HYE74_RS01640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYE74_RS01650	COG2188	Transcriptional regulator
HYE74_RS01660	COG2222	sugar isomerase
HYE74_RS01665	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HYE74_RS01685	COG2848	UPF0210 protein
HYE74_RS01690	COG1609	Transcriptional regulator
HYE74_RS01700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYE74_RS01715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HYE74_RS01730	COG5577	PFAM Coat F domain
HYE74_RS01735	COG0667	Aldo Keto reductase
HYE74_RS01750	COG1113	amino acid transport
HYE74_RS01760	COG3104	oligopeptide transport
HYE74_RS01765	COG0833	amino acid
HYE74_RS01775	COG3842	ATPase activity
HYE74_RS01780	COG1176	ABC-type spermidine putrescine transport system, permease component I
HYE74_RS01800	COG0531	amino acid
HYE74_RS01805	COG1556	Lactate utilization protein
HYE74_RS01810	COG1139	Iron-sulfur cluster binding protein
HYE74_RS01815	COG0247	lactate metabolic process
HYE74_RS01820	COG0531	amino acid
HYE74_RS01825	COG1979	alcohol dehydrogenase
HYE74_RS01830	COG0004	ammonium transporteR
HYE74_RS01835	COG3290	protein histidine kinase activity
HYE74_RS01840	COG4565	transcriptional regulatory protein
HYE74_RS01845	COG2851	Citrate transporter
HYE74_RS01850	COG0463	Glycosyl transferase, family 2
HYE74_RS01855	COG3973	AAA domain
HYE74_RS01865	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HYE74_RS01870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HYE74_RS01875	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYE74_RS01880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HYE74_RS01885	COG1301	dicarboxylic acid transport
HYE74_RS01890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYE74_RS01905	COG1902	pentaerythritol trinitrate reductase activity
HYE74_RS01920	COG0423	glycine-tRNA ligase activity
HYE74_RS01925	COG0531	amino acid
HYE74_RS01935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HYE74_RS01940	COG0628	permease
HYE74_RS01955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYE74_RS01960	COG0765	amino acid transport
HYE74_RS01965	COG0765	amino acid transport
HYE74_RS01980	COG1733	regulation of RNA biosynthetic process
HYE74_RS01990	COG0586	Pfam SNARE associated Golgi protein
HYE74_RS01995	COG0586	Pfam SNARE associated Golgi protein
HYE74_RS02020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HYE74_RS02020	COG0646	methionine synthase
HYE74_RS02025	COG0646	methionine synthase
HYE74_RS02025	COG1410	methionine synthase
HYE74_RS02050	COG3944	biosynthesis protein
HYE74_RS02055	COG0489	protein tyrosine kinase activity
HYE74_RS02060	COG4464	protein tyrosine phosphatase activity
HYE74_RS02065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYE74_RS02070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYE74_RS02080	COG1215	transferase activity, transferring glycosyl groups
HYE74_RS02080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYE74_RS02115	COG1091	dTDP-4-dehydrorhamnose reductase activity
HYE74_RS02125	COG1196	nuclear chromosome segregation
HYE74_RS02140	COG1501	Belongs to the glycosyl hydrolase 31 family
HYE74_RS02150	COG2115	Belongs to the xylose isomerase family
HYE74_RS02155	COG1070	Carbohydrate kinase
HYE74_RS02195	COG1070	Carbohydrate kinase
HYE74_RS02205	COG1940	carbohydrate kinase activity
HYE74_RS02215	COG1063	alcohol dehydrogenase
HYE74_RS02235	COG4193	domain, Protein
HYE74_RS02255	COG5504	Zn-dependent protease
HYE74_RS02260	COG2226	methyltransferase
HYE74_RS02300	COG3716	PTS system mannose fructose sorbose family IID component
HYE74_RS02305	COG3715	PTS system
HYE74_RS02310	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYE74_RS02315	COG0363	glucosamine-6-phosphate deaminase activity
HYE74_RS02320	COG2188	Transcriptional regulator
HYE74_RS02325	COG1396	sequence-specific DNA binding
HYE74_RS02335	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HYE74_RS02340	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYE74_RS02345	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HYE74_RS02345	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HYE74_RS02355	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYE74_RS02355	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYE74_RS02360	COG3715	PTS system
HYE74_RS02365	COG3716	PTS system mannose fructose sorbose family IID component
HYE74_RS02395	COG1131	(ABC) transporter
HYE74_RS02415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYE74_RS02425	COG0145	ligase activity
HYE74_RS02435	COG2315	Protein conserved in bacteria
HYE74_RS02445	COG0658	competence protein
HYE74_RS02445	COG2333	competence protein COMEC
HYE74_RS02465	COG0531	amino acid
HYE74_RS02480	COG1316	TRANSCRIPTIONal
HYE74_RS02490	COG4989	oxidoreductase activity
HYE74_RS02515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYE74_RS02520	COG2130	NADP-dependent
HYE74_RS02530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYE74_RS02530	COG3711	transcriptional antiterminator
HYE74_RS02535	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYE74_RS02540	COG1447	Phosphotransferase system cellobiose-specific component IIA
HYE74_RS02550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYE74_RS02555	COG2211	Major facilitator Superfamily
HYE74_RS02555	COG2190	(PTS) system
HYE74_RS02565	COG1113	amino acid transport
HYE74_RS02580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYE74_RS02590	COG2814	Major facilitator Superfamily
HYE74_RS02595	COG1609	Transcriptional regulator
HYE74_RS02605	COG1174	glycine betaine transport
HYE74_RS02610	COG1732	Glycine betaine
HYE74_RS02615	COG1174	glycine betaine transport
HYE74_RS02620	COG0517	IMP dehydrogenase activity
HYE74_RS02620	COG1125	glycine betaine transport
HYE74_RS02625	COG1510	regulation of RNA biosynthetic process
HYE74_RS02630	COG0110	maltose O-acetyltransferase activity
HYE74_RS02635	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS02645	COG4297	protein containing double-stranded beta helix domain
HYE74_RS02655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYE74_RS02660	COG2272	Belongs to the type-B carboxylesterase lipase family
HYE74_RS02665	COG0606	chelatase, subunit chli
HYE74_RS02680	COG0371	Dehydrogenase
HYE74_RS02685	COG2814	Major facilitator Superfamily
HYE74_RS02690	COG1070	Carbohydrate kinase
HYE74_RS02695	COG2115	Belongs to the xylose isomerase family
HYE74_RS02710	COG0157	Belongs to the NadC ModD family
HYE74_RS02715	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HYE74_RS02720	COG1104	cysteine desulfurase activity
HYE74_RS02730	COG2116	formate transmembrane transporter activity
HYE74_RS02750	COG4720	Psort location CytoplasmicMembrane, score
HYE74_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS02765	COG2610	gluconate transmembrane transporter activity
HYE74_RS02770	COG1012	belongs to the aldehyde dehydrogenase family
HYE74_RS02780	COG3290	protein histidine kinase activity
HYE74_RS02780	COG3829	transcription factor binding
HYE74_RS02785	COG1501	Belongs to the glycosyl hydrolase 31 family
HYE74_RS02795	COG1960	acyl-CoA dehydrogenase activity
HYE74_RS02800	COG0318	PFAM AMP-dependent synthetase and ligase
HYE74_RS02815	COG1309	transcriptional regulator
HYE74_RS02830	COG1363	Peptidase, m42
HYE74_RS02870	COG2972	Histidine kinase
HYE74_RS02890	COG0531	amino acid
HYE74_RS02900	COG1620	l-lactate permease
HYE74_RS02905	COG2186	Transcriptional regulator
HYE74_RS02960	COG1447	Phosphotransferase system cellobiose-specific component IIA
HYE74_RS02975	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYE74_RS02975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYE74_RS02980	COG2723	6-phospho-beta-galactosidase activity
HYE74_RS02985	COG3711	transcriptional antiterminator
HYE74_RS02985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYE74_RS02995	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HYE74_RS03005	COG1131	(ABC) transporter
HYE74_RS03015	COG0626	cystathionine gamma-synthase activity
HYE74_RS03020	COG0626	cystathionine gamma-synthase activity
HYE74_RS03040	COG1653	transport
HYE74_RS03045	COG2207	Transcriptional regulator
HYE74_RS03080	COG0604	alcohol dehydrogenase
HYE74_RS03085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HYE74_RS03090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYE74_RS03110	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS03115	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HYE74_RS03125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HYE74_RS03135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYE74_RS03140	COG1316	TRANSCRIPTIONal
HYE74_RS03155	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HYE74_RS03170	COG1388	LysM domain
HYE74_RS03170	COG3584	3D domain protein
HYE74_RS03180	COG0488	(ABC) transporter
HYE74_RS03185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYE74_RS03195	COG0011	TIGRFAM Protein of
HYE74_RS03200	COG2706	6-phosphogluconolactonase activity
HYE74_RS03210	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HYE74_RS03210	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HYE74_RS03215	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYE74_RS03215	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYE74_RS03225	COG3715	PTS system
HYE74_RS03230	COG3716	PTS system mannose fructose sorbose family IID component
HYE74_RS03245	COG2079	MmgE PrpD family protein
HYE74_RS03250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HYE74_RS03260	COG0154	amidase activity
HYE74_RS03270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYE74_RS03275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYE74_RS03280	COG1116	anion transmembrane transporter activity
HYE74_RS03285	COG0083	homoserine kinase activity
HYE74_RS03290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYE74_RS03295	COG0460	homoserine dehydrogenase
HYE74_RS03300	COG0010	Belongs to the arginase family
HYE74_RS03310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HYE74_RS03315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYE74_RS03325	COG4145	pantothenate transmembrane transporter activity
HYE74_RS03340	COG1454	alcohol dehydrogenase
HYE74_RS03340	COG1012	belongs to the aldehyde dehydrogenase family
HYE74_RS03360	COG1388	LysM domain
HYE74_RS03360	COG0791	NLP P60 protein
HYE74_RS03365	COG0024	Methionine aminopeptidase
HYE74_RS03370	COG1268	BioY protein
HYE74_RS03380	COG0318	PFAM AMP-dependent synthetase and ligase
HYE74_RS03385	COG1960	acyl-CoA dehydrogenase activity
HYE74_RS03390	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS03395	COG2746	aminoglycoside 3-N-acetyltransferase activity
HYE74_RS03400	COG2244	polysaccharide biosynthetic process
HYE74_RS03405	COG0589	response to stress
HYE74_RS03420	COG0535	radical SAM domain protein
HYE74_RS03425	COG0457	Tetratricopeptide repeat
HYE74_RS03430	COG1063	alcohol dehydrogenase
HYE74_RS03435	COG2211	Major facilitator Superfamily
HYE74_RS03440	COG1609	Transcriptional regulator
HYE74_RS03450	COG0561	phosphatase activity
HYE74_RS03475	COG0657	acetylesterase activity
HYE74_RS03480	COG0656	L-ascorbic acid biosynthetic process
HYE74_RS03485	COG0431	NADPH-dependent FMN reductase
HYE74_RS03490	COG0420	3'-5' exonuclease activity
HYE74_RS03495	COG4717	serine-type aminopeptidase activity
HYE74_RS03500	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYE74_RS03505	COG0534	Mate efflux family protein
HYE74_RS03510	COG1664	Polymer-forming cytoskeletal
HYE74_RS03520	COG0789	Transcriptional regulator
HYE74_RS03525	COG0436	Aminotransferase
HYE74_RS03530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HYE74_RS03540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYE74_RS03550	COG2226	methyltransferase
HYE74_RS03565	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HYE74_RS03605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HYE74_RS03610	COG1113	amino acid transport
HYE74_RS03615	COG2814	Major facilitator Superfamily
HYE74_RS03635	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HYE74_RS03650	COG1960	acyl-CoA dehydrogenase activity
HYE74_RS03670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYE74_RS03675	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HYE74_RS03685	COG1609	Transcriptional regulator
HYE74_RS03700	COG2996	Protein conserved in bacteria
HYE74_RS03705	COG0346	lactoylglutathione lyase activity
HYE74_RS03710	COG1482	cell wall glycoprotein biosynthetic process
HYE74_RS03720	COG0477	Major facilitator Superfamily
HYE74_RS03725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HYE74_RS03735	COG2188	Transcriptional regulator
HYE74_RS03740	COG1388	LysM domain
HYE74_RS03740	COG0791	NLP P60 protein
HYE74_RS03750	COG0768	penicillin binding
HYE74_RS03755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYE74_RS03760	COG1739	Uncharacterized protein family UPF0029
HYE74_RS03770	COG2197	response regulator
HYE74_RS03775	COG0531	amino acid
HYE74_RS03780	COG1307	EDD domain protein, DegV family
HYE74_RS03785	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HYE74_RS03790	COG1040	competence protein
HYE74_RS03800	COG2747	anti-sigma28 factor FlgM
HYE74_RS03810	COG1256	bacterial-type flagellum assembly
HYE74_RS03810	COG4786	Flagellar basal body rod
HYE74_RS03815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYE74_RS03850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HYE74_RS03875	COG1285	pathogenesis
HYE74_RS03885	COG1113	amino acid transport
HYE74_RS03895	COG1067	ATP-dependent peptidase activity
HYE74_RS03905	COG2094	Belongs to the DNA glycosylase MPG family
HYE74_RS03915	COG1334	flagellar protein FlaG
HYE74_RS03920	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HYE74_RS03925	COG1516	flagellar protein fliS
HYE74_RS03945	COG0653	protein targeting
HYE74_RS03955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYE74_RS03965	COG2884	Cell division ATP-binding protein ftsE
HYE74_RS03970	COG2177	Part of the ABC transporter FtsEX involved in
HYE74_RS03975	COG0739	heme binding
HYE74_RS03990	COG0460	homoserine dehydrogenase
HYE74_RS03995	COG0793	Belongs to the peptidase S41A family
HYE74_RS03995	COG3409	Peptidoglycan-binding domain 1 protein
HYE74_RS04000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYE74_RS04005	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYE74_RS04010	COG4605	iron ion homeostasis
HYE74_RS04015	COG4604	ABC transporter, ATP-binding protein
HYE74_RS04020	COG4607	ABC-type enterochelin transport system periplasmic component
HYE74_RS04035	COG0745	RESPONSE REGULATOR receiver
HYE74_RS04040	COG5002	protein histidine kinase activity
HYE74_RS04045	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HYE74_RS04060	COG0573	inorganic phosphate transmembrane transporter activity
HYE74_RS04065	COG0581	inorganic phosphate transmembrane transporter activity
HYE74_RS04075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYE74_RS04080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYE74_RS04105	COG0556	nucleotide-excision repair
HYE74_RS04110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYE74_RS04115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HYE74_RS04125	COG0463	Glycosyl transferase, family 2
HYE74_RS04135	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYE74_RS04140	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYE74_RS04140	COG0463	Glycosyl transferase, family 2
HYE74_RS04145	COG1682	transport, permease protein
HYE74_RS04150	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HYE74_RS04155	COG3595	metallopeptidase activity
HYE74_RS04165	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HYE74_RS04175	COG0546	phosphoglycolate phosphatase activity
HYE74_RS04180	COG0110	maltose O-acetyltransferase activity
HYE74_RS04185	COG0457	Tetratricopeptide repeat
HYE74_RS04190	COG0492	ferredoxin-NADP+ reductase activity
HYE74_RS04195	COG1051	belongs to the nudix hydrolase family
HYE74_RS04200	COG1660	Displays ATPase and GTPase activities
HYE74_RS04205	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HYE74_RS04210	COG1481	regulation of sporulation
HYE74_RS04215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYE74_RS04250	COG3842	ATPase activity
HYE74_RS04255	COG2508	Transcriptional regulator
HYE74_RS04265	COG0189	ligase activity
HYE74_RS04270	COG0189	ligase activity
HYE74_RS04280	COG4399	Belongs to the UPF0754 family
HYE74_RS04290	COG0561	phosphatase activity
HYE74_RS04295	COG1024	Enoyl-CoA hydratase
HYE74_RS04305	COG0861	Integral membrane protein TerC family
HYE74_RS04310	COG0701	Predicted permease
HYE74_RS04315	COG3689	TIGRFAM TIGR03943 family protein
HYE74_RS04320	COG0420	3'-5' exonuclease activity
HYE74_RS04325	COG4717	serine-type aminopeptidase activity
HYE74_RS04330	COG3481	metal-dependent phosphohydrolase, HD sub domain
HYE74_RS04340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYE74_RS04355	COG1846	Transcriptional regulator
HYE74_RS04375	COG0537	adenosine 5'-monophosphoramidase activity
HYE74_RS04380	COG1131	(ABC) transporter
HYE74_RS04385	COG4473	ABC transporter
HYE74_RS04390	COG1473	amidohydrolase
HYE74_RS04395	COG3069	C4-dicarboxylate transmembrane transporter activity
HYE74_RS04400	COG2329	Antibiotic biosynthesis monooxygenase
HYE74_RS04405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HYE74_RS04410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HYE74_RS04415	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HYE74_RS04420	COG1309	transcriptional regulator
HYE74_RS04425	COG1511	domain protein
HYE74_RS04430	COG1263	PTS System
HYE74_RS04430	COG2190	(PTS) system
HYE74_RS04430	COG1263	PTS System
HYE74_RS04430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYE74_RS04430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HYE74_RS04430	COG2190	(PTS) system
HYE74_RS04435	COG1349	DNA-binding transcription factor activity
HYE74_RS04440	COG3254	rhamnose metabolic process
HYE74_RS04445	COG2814	Major facilitator Superfamily
HYE74_RS04450	COG0697	spore germination
HYE74_RS04455	COG1012	belongs to the aldehyde dehydrogenase family
HYE74_RS04460	COG1999	signal sequence binding
HYE74_RS04475	COG0095	Lipoate-protein ligase
HYE74_RS04480	COG0318	PFAM AMP-dependent synthetase and ligase
HYE74_RS04485	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HYE74_RS04495	COG0501	Belongs to the peptidase M48B family
HYE74_RS04515	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HYE74_RS04520	COG1074	ATP-dependent DNA helicase activity
HYE74_RS04555	COG2311	Membrane
HYE74_RS04560	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYE74_RS04580	COG1307	EDD domain protein, DegV family
HYE74_RS04595	COG0561	phosphatase activity
HYE74_RS04600	COG2151	metal-sulfur cluster biosynthetic enzyme
HYE74_RS04630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYE74_RS04635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYE74_RS04650	COG4608	Belongs to the ABC transporter superfamily
HYE74_RS04655	COG0601	transmembrane transport
HYE74_RS04665	COG0747	negative chemotaxis
HYE74_RS04675	COG0180	Tryptophanyl-tRNA synthetase
HYE74_RS04685	COG4166	transmembrane transport
HYE74_RS04690	COG0601	transmembrane transport
HYE74_RS04695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYE74_RS04700	COG0444	Belongs to the ABC transporter superfamily
HYE74_RS04705	COG4608	Belongs to the ABC transporter superfamily
HYE74_RS04710	COG1393	Belongs to the ArsC family
HYE74_RS04715	COG4862	establishment of competence for transformation
HYE74_RS04720	COG4469	Competence protein
HYE74_RS04725	COG1164	Oligoendopeptidase f
HYE74_RS04735	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HYE74_RS04740	COG2346	COG2346, Truncated hemoglobins
HYE74_RS04745	COG0741	lytic transglycosylase activity
HYE74_RS04750	COG4116	CYTH
HYE74_RS04760	COG2357	RelA SpoT domain protein
HYE74_RS04770	COG0564	pseudouridine synthase activity
HYE74_RS04775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HYE74_RS04780	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HYE74_RS04815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HYE74_RS04850	COG2153	protein acetylation
HYE74_RS04860	COG2382	esterase
HYE74_RS04900	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYE74_RS04905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HYE74_RS04910	COG1447	Phosphotransferase system cellobiose-specific component IIA
HYE74_RS04915	COG2723	6-phospho-beta-galactosidase activity
HYE74_RS04920	COG2188	Transcriptional regulator
HYE74_RS04925	COG1940	carbohydrate kinase activity
HYE74_RS04935	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS04940	COG4152	abc transporter atp-binding protein
HYE74_RS04945	COG1668	transmembrane transport
HYE74_RS04955	COG3579	cysteine-type endopeptidase activity
HYE74_RS04985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYE74_RS04990	COG2059	Chromate
HYE74_RS04995	COG2059	Chromate
HYE74_RS05000	COG1522	sequence-specific DNA binding
HYE74_RS05005	COG0477	Major facilitator Superfamily
HYE74_RS05010	COG0405	Gamma-glutamyltransferase
HYE74_RS05015	COG0154	amidase activity
HYE74_RS05040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYE74_RS05045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HYE74_RS05055	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HYE74_RS05105	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS05120	COG1959	2 iron, 2 sulfur cluster binding
HYE74_RS05130	COG0730	response to heat
HYE74_RS05135	COG0783	Belongs to the Dps family
HYE74_RS05140	COG0673	inositol 2-dehydrogenase activity
HYE74_RS05145	COG3852	Histidine kinase
HYE74_RS05150	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HYE74_RS05160	COG0861	Integral membrane protein TerC family
HYE74_RS05180	COG5002	protein histidine kinase activity
HYE74_RS05185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYE74_RS05205	COG0542	response to heat
HYE74_RS05210	COG3949	Membrane
HYE74_RS05220	COG4873	Protein conserved in bacteria
HYE74_RS05230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYE74_RS05245	COG2084	Dehydrogenase
HYE74_RS05250	COG0436	Aminotransferase
HYE74_RS05255	COG0784	Response regulator, receiver
HYE74_RS05255	COG0835	chemotaxis
HYE74_RS05265	COG2409	Drug exporters of the RND superfamily
HYE74_RS05265	COG1033	growth of symbiont in host cell
HYE74_RS05280	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS05290	COG4703	Protein of unknown function (DUF1797)
HYE74_RS05295	COG0517	IMP dehydrogenase activity
HYE74_RS05300	COG0583	DNA-binding transcription factor activity
HYE74_RS05305	COG2171	N-acyltransferase activity
HYE74_RS05310	COG1473	amidohydrolase
HYE74_RS05320	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HYE74_RS05365	COG1982	Orn Lys Arg decarboxylase major
HYE74_RS05375	COG4476	Belongs to the UPF0223 family
HYE74_RS05390	COG0483	inositol monophosphate 1-phosphatase activity
HYE74_RS05400	COG1217	gtp-binding protein TYPA
HYE74_RS05410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HYE74_RS05415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HYE74_RS05420	COG4838	Belongs to the UPF0358 family
HYE74_RS05425	COG0772	Belongs to the SEDS family
HYE74_RS05430	COG1612	heme a metabolic process
HYE74_RS05435	COG0109	protoheme IX farnesyltransferase activity
HYE74_RS05455	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HYE74_RS05460	COG3336	cytochrome c oxidase
HYE74_RS05470	COG2340	Cysteine-rich secretory protein family
HYE74_RS05475	COG2050	protein possibly involved in aromatic compounds catabolism
HYE74_RS05505	COG3679	Belongs to the UPF0342 family
HYE74_RS05510	COG4471	UPF0298 protein
HYE74_RS05520	COG0742	ribosomal rna small subunit methyltransferase
HYE74_RS05525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HYE74_RS05530	COG3314	Sporulation integral membrane protein YlbJ
HYE74_RS05535	COG1752	Esterase of the alpha-beta hydrolase superfamily
HYE74_RS05540	COG3480	Lon protease (S16) C-terminal proteolytic domain
HYE74_RS05545	COG1323	Belongs to the UPF0348 family
HYE74_RS05550	COG1399	metal-binding, possibly nucleic acid-binding protein
HYE74_RS05555	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HYE74_RS05565	COG0454	-acetyltransferase
HYE74_RS05570	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HYE74_RS05575	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HYE74_RS05580	COG2001	Belongs to the MraZ family
HYE74_RS05585	COG0275	rRNA processing
HYE74_RS05590	COG4839	cell division protein FtsL
HYE74_RS05595	COG0768	penicillin binding
HYE74_RS05600	COG0768	penicillin binding
HYE74_RS05615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HYE74_RS05620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HYE74_RS05625	COG0772	Belongs to the SEDS family
HYE74_RS05630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYE74_RS05635	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HYE74_RS05640	COG0849	cell division
HYE74_RS05645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYE74_RS05655	COG1191	sigma factor activity
HYE74_RS05660	COG1191	sigma factor activity
HYE74_RS05665	COG1873	PFAM PRC-barrel domain
HYE74_RS05670	COG3584	3D domain protein
HYE74_RS05670	COG1388	LysM domain
HYE74_RS05680	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HYE74_RS05685	COG1799	cell septum assembly
HYE74_RS05690	COG0762	integral membrane protein
HYE74_RS05695	COG2302	S4 RNA-binding domain
HYE74_RS05700	COG3599	regulation of cell shape
HYE74_RS05715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HYE74_RS05720	COG0564	pseudouridine synthase activity
HYE74_RS05730	COG0540	Belongs to the ATCase OTCase family
HYE74_RS05735	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HYE74_RS05755	COG0167	dihydroorotate dehydrogenase activity
HYE74_RS05765	COG0284	orotidine-5'-phosphate decarboxylase activity
HYE74_RS05770	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HYE74_RS05785	COG2207	Transcriptional regulator
HYE74_RS05785	COG1917	Cupin 2, conserved barrel domain protein
HYE74_RS05790	COG1070	Carbohydrate kinase
HYE74_RS05795	COG4806	L-rhamnose isomerase
HYE74_RS05800	COG0235	Class ii aldolase
HYE74_RS05805	COG1454	alcohol dehydrogenase
HYE74_RS05810	COG1803	Methylglyoxal synthase
HYE74_RS05815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HYE74_RS05820	COG0477	Major facilitator Superfamily
HYE74_RS05825	COG0477	Major facilitator Superfamily
HYE74_RS05830	COG1309	transcriptional regulator
HYE74_RS05845	COG0628	permease
HYE74_RS05850	COG0561	phosphatase activity
HYE74_RS05870	COG1131	(ABC) transporter
HYE74_RS05890	COG2207	Transcriptional regulator
HYE74_RS05900	COG2376	Dihydroxyacetone kinase
HYE74_RS05905	COG1461	Dihydroxyacetone kinase
HYE74_RS05910	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HYE74_RS05920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HYE74_RS05925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYE74_RS05935	COG1522	sequence-specific DNA binding
HYE74_RS05945	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HYE74_RS05955	COG1794	racemase activity, acting on amino acids and derivatives
HYE74_RS05970	COG0720	synthase
HYE74_RS05980	COG0385	Bile acid
HYE74_RS05990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HYE74_RS05995	COG1561	YicC-like family, N-terminal region
HYE74_RS06000	COG2052	Domain of unknown function (DUF370)
HYE74_RS06005	COG0194	GDP metabolic process
HYE74_RS06010	COG1758	RNA polymerase activity
HYE74_RS06015	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYE74_RS06020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYE74_RS06025	COG0242	peptide deformylase activity
HYE74_RS06030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HYE74_RS06040	COG0631	protein serine/threonine phosphatase activity
HYE74_RS06045	COG0515	serine threonine protein kinase
HYE74_RS06045	COG2815	serine threonine protein kinase
HYE74_RS06055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYE74_RS06060	COG1564	THIamine pyrophosphokinase
HYE74_RS06070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HYE74_RS06075	COG1302	Protein conserved in bacteria
HYE74_RS06080	COG1461	Dihydroxyacetone kinase
HYE74_RS06090	COG1760	l-serine dehydratase
HYE74_RS06095	COG1760	l-serine dehydratase
HYE74_RS06100	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYE74_RS06105	COG1349	DNA-binding transcription factor activity
HYE74_RS06110	COG0416	fatty acid biosynthetic process
HYE74_RS06115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYE74_RS06120	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS06130	COG0571	ribonuclease III activity
HYE74_RS06135	COG1196	nuclear chromosome segregation
HYE74_RS06140	COG0552	protein localization to endoplasmic reticulum
HYE74_RS06145	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HYE74_RS06150	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYE74_RS06160	COG1837	Belongs to the UPF0109 family
HYE74_RS06170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HYE74_RS06175	COG0336	Belongs to the RNA methyltransferase TrmD family
HYE74_RS06190	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HYE74_RS06205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYE74_RS06210	COG0045	succinate-CoA ligase (ADP-forming) activity
HYE74_RS06215	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HYE74_RS06220	COG0758	DNA mediated transformation
HYE74_RS06225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYE74_RS06235	COG4974	Belongs to the 'phage' integrase family
HYE74_RS06240	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HYE74_RS06250	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HYE74_RS06255	COG1815	bacterial-type flagellum-dependent cell motility
HYE74_RS06260	COG1558	bacterial-type flagellum-dependent cell motility
HYE74_RS06265	COG1677	Flagellar hook-basal body complex protein FliE
HYE74_RS06270	COG1766	The M ring may be actively involved in energy transduction
HYE74_RS06275	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYE74_RS06280	COG1317	bacterial-type flagellum organization
HYE74_RS06285	COG1157	protein secretion by the type III secretion system
HYE74_RS06290	COG2882	bacterial-type flagellum organization
HYE74_RS06305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HYE74_RS06315	COG4786	Flagellar basal body rod
HYE74_RS06325	COG1580	Controls the rotational direction of flagella during chemotaxis
HYE74_RS06330	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYE74_RS06335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HYE74_RS06335	COG1776	CheC inhibitor of MCP methylation
HYE74_RS06340	COG2201	protein-glutamate methylesterase activity
HYE74_RS06345	COG3190	flagellar
HYE74_RS06350	COG1338	Plays a role in the flagellum-specific transport system
HYE74_RS06355	COG1987	bacterial-type flagellum assembly
HYE74_RS06360	COG1684	flagellar biosynthetic protein fliR
HYE74_RS06365	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYE74_RS06370	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HYE74_RS06375	COG1419	protein localization to endoplasmic reticulum
HYE74_RS06380	COG0455	bacterial-type flagellum organization
HYE74_RS06385	COG2201	protein-glutamate methylesterase activity
HYE74_RS06390	COG2198	Histidine kinase
HYE74_RS06390	COG0643	Histidine kinase
HYE74_RS06395	COG0835	chemotaxis
HYE74_RS06400	COG1776	CheC inhibitor of MCP methylation
HYE74_RS06405	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HYE74_RS06410	COG1191	sigma factor activity
HYE74_RS06420	COG0052	Belongs to the universal ribosomal protein uS2 family
HYE74_RS06425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HYE74_RS06430	COG0528	UMP kinase activity
HYE74_RS06435	COG0233	cytoplasmic translational termination
HYE74_RS06440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYE74_RS06445	COG4589	Belongs to the CDS family
HYE74_RS06455	COG0750	zinc metalloprotease
HYE74_RS06460	COG0442	prolyl-tRNA aminoacylation
HYE74_RS06465	COG2176	DNA-directed DNA polymerase activity
HYE74_RS06470	COG0779	Required for maturation of 30S ribosomal subunits
HYE74_RS06475	COG0195	Participates in both transcription termination and antitermination
HYE74_RS06480	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HYE74_RS06485	COG1358	cellular component organization or biogenesis
HYE74_RS06495	COG1550	Protein conserved in bacteria
HYE74_RS06500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HYE74_RS06505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYE74_RS06510	COG0196	riboflavin kinase activity
HYE74_RS06515	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HYE74_RS06520	COG1185	polyribonucleotide nucleotidyltransferase activity
HYE74_RS06525	COG0726	polysaccharide deacetylase
HYE74_RS06530	COG0612	Peptidase, M16
HYE74_RS06535	COG1873	PFAM PRC-barrel domain
HYE74_RS06540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYE74_RS06545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYE74_RS06550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HYE74_RS06555	COG0527	aspartate kinase activity
HYE74_RS06565	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HYE74_RS06580	COG4980	gas vesicle protein
HYE74_RS06580	COG1674	ftsk spoiiie
HYE74_RS06585	COG1744	ABC transporter substrate-binding protein PnrA-like
HYE74_RS06590	COG3845	ABC transporter
HYE74_RS06595	COG4603	Belongs to the binding-protein-dependent transport system permease family
HYE74_RS06600	COG1079	Belongs to the binding-protein-dependent transport system permease family
HYE74_RS06605	COG0612	Peptidase, M16
HYE74_RS06610	COG0612	Peptidase, M16
HYE74_RS06615	COG0300	oxidoreductase activity
HYE74_RS06630	COG1426	Protein conserved in bacteria
HYE74_RS06635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYE74_RS06640	COG1058	Belongs to the CinA family
HYE74_RS06640	COG1546	Belongs to the CinA family
HYE74_RS06650	COG1418	mRNA catabolic process
HYE74_RS06655	COG1692	metallophosphoesterase
HYE74_RS06660	COG2359	stage V sporulation protein S
HYE74_RS06665	COG0826	peptidase U32
HYE74_RS06670	COG0826	peptidase U32
HYE74_RS06675	COG0531	amino acid
HYE74_RS06680	COG3829	transcription factor binding
HYE74_RS06685	COG1012	belongs to the aldehyde dehydrogenase family
HYE74_RS06695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYE74_RS06700	COG4550	Control of competence regulator ComK, YlbF/YmcA
HYE74_RS06710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HYE74_RS06715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HYE74_RS06740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HYE74_RS06750	COG0464	growth
HYE74_RS06755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYE74_RS06760	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HYE74_RS06765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYE74_RS06785	COG1321	iron dependent repressor
HYE74_RS06790	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HYE74_RS06800	COG1418	mRNA catabolic process
HYE74_RS06805	COG0488	(ABC) transporter
HYE74_RS06810	COG1413	lyase activity
HYE74_RS06825	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HYE74_RS06830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HYE74_RS06835	COG1272	protein, Hemolysin III
HYE74_RS06840	COG2755	lipolytic protein G-D-S-L family
HYE74_RS06850	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HYE74_RS06850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYE74_RS06855	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYE74_RS06860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYE74_RS06870	COG0840	transmembrane signaling receptor activity
HYE74_RS06875	COG4479	Belongs to the UPF0346 family
HYE74_RS06895	COG1876	peptidase activity
HYE74_RS06900	COG3409	Peptidoglycan-binding domain 1 protein
HYE74_RS06900	COG0793	Belongs to the peptidase S41A family
HYE74_RS06905	COG1846	Transcriptional regulator
HYE74_RS06910	COG2340	Cysteine-rich secretory protein family
HYE74_RS06915	COG0534	Mate efflux family protein
HYE74_RS06930	COG3285	dna ligase
HYE74_RS06930	COG1793	dna ligase
HYE74_RS06935	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HYE74_RS06940	COG0671	phosphoesterase, PA-phosphatase related
HYE74_RS06945	COG1368	sulfuric ester hydrolase activity
HYE74_RS06960	COG1331	Highly conserved protein containing a thioredoxin domain
HYE74_RS06965	COG2814	Major facilitator Superfamily
HYE74_RS06970	COG0745	RESPONSE REGULATOR receiver
HYE74_RS06975	COG5002	protein histidine kinase activity
HYE74_RS06985	COG0567	Dehydrogenase, E1 component
HYE74_RS06990	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYE74_RS06995	COG1012	belongs to the aldehyde dehydrogenase family
HYE74_RS07015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYE74_RS07025	COG1054	Belongs to the UPF0176 family
HYE74_RS07030	COG2135	peptidase activity
HYE74_RS07040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYE74_RS07045	COG0516	GMP reductase activity
HYE74_RS07045	COG0517	IMP dehydrogenase activity
HYE74_RS07050	COG0723	plastoquinol--plastocyanin reductase activity
HYE74_RS07050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYE74_RS07055	COG1388	LysM domain
HYE74_RS07055	COG3584	3D domain protein
HYE74_RS07060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYE74_RS07065	COG1113	amino acid transport
HYE74_RS07070	COG1280	lysine exporter protein (LysE YggA)
HYE74_RS07075	COG0598	Magnesium transport protein CorA
HYE74_RS07085	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HYE74_RS07090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HYE74_RS07095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HYE74_RS07100	COG0131	Imidazoleglycerol-phosphate dehydratase
HYE74_RS07105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HYE74_RS07115	COG0107	imidazoleglycerol-phosphate synthase activity
HYE74_RS07120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HYE74_RS07120	COG0140	phosphoribosyl-ATP diphosphatase activity
HYE74_RS07130	COG2391	methyltransferase activity
HYE74_RS07135	COG2962	Rard protein
HYE74_RS07140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYE74_RS07145	COG0569	domain protein
HYE74_RS07165	COG2807	transmembrane transport
HYE74_RS07170	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HYE74_RS07180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HYE74_RS07190	COG1278	Cold shock
HYE74_RS07195	COG0302	gtp cyclohydrolase
HYE74_RS07200	COG0492	ferredoxin-NADP+ reductase activity
HYE74_RS07215	COG0577	efflux transmembrane transporter activity
HYE74_RS07220	COG1136	(ABC) transporter
HYE74_RS07225	COG0642	Histidine kinase
HYE74_RS07230	COG0745	RESPONSE REGULATOR receiver
HYE74_RS07245	COG0640	Transcriptional regulator
HYE74_RS07250	COG2814	Major facilitator Superfamily
HYE74_RS07255	COG5039	Polysaccharide pyruvyl transferase
HYE74_RS07265	COG1113	amino acid transport
HYE74_RS07280	COG0477	Major facilitator Superfamily
HYE74_RS07290	COG1132	(ABC) transporter
HYE74_RS07295	COG1132	(ABC) transporter
HYE74_RS07305	COG1380	Effector of murein hydrolase LrgA
HYE74_RS07310	COG1346	cytolysis
HYE74_RS07315	COG0318	PFAM AMP-dependent synthetase and ligase
HYE74_RS07340	COG2309	aminopeptidase activity
HYE74_RS07350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HYE74_RS07370	COG0824	Thioesterase
HYE74_RS07380	COG4841	protein insertion into membrane
HYE74_RS07385	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HYE74_RS07390	COG1832	CoA-binding protein
HYE74_RS07395	COG0187	DNA topoisomerase II activity
HYE74_RS07400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYE74_RS07415	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HYE74_RS07420	COG0574	Belongs to the PEP-utilizing enzyme family
HYE74_RS07420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYE74_RS07445	COG2070	2-Nitropropane dioxygenase
HYE74_RS07455	COG0681	Belongs to the peptidase S26 family
HYE74_RS07460	COG0473	3-isopropylmalate dehydrogenase activity
HYE74_RS07465	COG2226	methyltransferase
HYE74_RS07490	COG0456	acetyltransferase
HYE74_RS07495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYE74_RS07500	COG0456	acetyltransferase
HYE74_RS07510	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYE74_RS07515	COG0351	phosphomethylpyrimidine kinase
HYE74_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS07525	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HYE74_RS07530	COG0351	phosphomethylpyrimidine kinase
HYE74_RS07545	COG2258	MOSC domain
HYE74_RS07575	COG1309	transcriptional regulator
HYE74_RS07580	COG2814	Major facilitator Superfamily
HYE74_RS07585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYE74_RS07590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYE74_RS07605	COG1809	phosphosulfolactate synthase activity
HYE74_RS07610	COG2045	Belongs to the ComB family
HYE74_RS07615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HYE74_RS07620	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYE74_RS07630	COG0789	Transcriptional regulator
HYE74_RS07635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYE74_RS07645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HYE74_RS07650	COG0022	dehydrogenase e1 component
HYE74_RS07655	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYE74_RS07660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYE74_RS07665	COG3284	Transcriptional regulator
HYE74_RS07670	COG1511	domain protein
HYE74_RS07670	COG3264	Mechanosensitive ion channel
HYE74_RS07685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYE74_RS07690	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HYE74_RS07705	COG0183	Belongs to the thiolase family
HYE74_RS07710	COG0318	PFAM AMP-dependent synthetase and ligase
HYE74_RS07720	COG0561	phosphatase activity
HYE74_RS07725	COG2322	membrane
HYE74_RS07740	COG0039	L-malate dehydrogenase activity
HYE74_RS07745	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS07750	COG2223	nitrite transmembrane transporter activity
HYE74_RS07755	COG3773	Cell wall hydrolase
HYE74_RS07760	COG0708	Exodeoxyribonuclease III
HYE74_RS07770	COG0297	glycogen (starch) synthase activity
HYE74_RS07775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYE74_RS07780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HYE74_RS07785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HYE74_RS07805	COG1247	-acetyltransferase
HYE74_RS07810	COG0494	nUDIX hydrolase
HYE74_RS07815	COG1914	H( )-stimulated, divalent metal cation uptake system
HYE74_RS07830	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HYE74_RS07835	COG1131	(ABC) transporter
HYE74_RS07860	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HYE74_RS07870	COG2030	dehydratase
HYE74_RS07875	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS07880	COG0277	FAD linked oxidase domain protein
HYE74_RS07890	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HYE74_RS07895	COG0709	Synthesizes selenophosphate from selenide and ATP
HYE74_RS07905	COG0701	Predicted permease
HYE74_RS07910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HYE74_RS07915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HYE74_RS07925	COG1252	NADH dehydrogenase
HYE74_RS07930	COG2404	hydrolase activity, acting on ester bonds
HYE74_RS07940	COG4990	cell redox homeostasis
HYE74_RS07945	COG0789	Transcriptional regulator
HYE74_RS07970	COG0436	Aminotransferase
HYE74_RS07975	COG0165	Argininosuccinate lyase
HYE74_RS07980	COG0137	argininosuccinate synthase activity
HYE74_RS07985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HYE74_RS07990	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HYE74_RS07995	COG0505	Belongs to the CarA family
HYE74_RS08000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYE74_RS08005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HYE74_RS08010	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HYE74_RS08015	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HYE74_RS08030	COG3546	catalase activity
HYE74_RS08050	COG1619	proteins homologs of microcin C7 resistance protein MccF
HYE74_RS08060	COG0204	Acyl-transferase
HYE74_RS08070	COG4846	Membrane protein involved in cytochrome C biogenesis
HYE74_RS08075	COG2201	protein-glutamate methylesterase activity
HYE74_RS08080	COG0785	Cytochrome C biogenesis protein
HYE74_RS08085	COG3763	UPF0154 protein
HYE74_RS08100	COG4224	UPF0291 protein
HYE74_RS08105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYE74_RS08115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HYE74_RS08120	COG0174	glutamine synthetase
HYE74_RS08125	COG0789	Transcriptional regulator
HYE74_RS08130	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HYE74_RS08145	COG2233	PERMEase
HYE74_RS08155	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HYE74_RS08160	COG0116	Belongs to the methyltransferase superfamily
HYE74_RS08175	COG4474	Belongs to the UPF0398 family
HYE74_RS08185	COG3359	exonuclease
HYE74_RS08190	COG1205	dead DEAH box helicase
HYE74_RS08190	COG1111	helicase
HYE74_RS08195	COG0071	Belongs to the small heat shock protein (HSP20) family
HYE74_RS08215	COG3331	DNA recombination
HYE74_RS08220	COG4499	WXG100 protein secretion system (Wss), protein YukC
HYE74_RS08220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYE74_RS08225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYE74_RS08230	COG3935	DnaD domain protein
HYE74_RS08235	COG0017	Asparaginyl-tRNA synthetase
HYE74_RS08250	COG1199	ATP-dependent helicase activity
HYE74_RS08250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYE74_RS08255	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HYE74_RS08260	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HYE74_RS08280	COG0438	transferase activity, transferring glycosyl groups
HYE74_RS08285	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HYE74_RS08290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HYE74_RS08295	COG1694	Mazg nucleotide pyrophosphohydrolase
HYE74_RS08300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYE74_RS08310	COG2738	Putative neutral zinc metallopeptidase
HYE74_RS08320	COG4347	Protein of unknown function (DUF1405)
HYE74_RS08330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HYE74_RS08345	COG5582	Belongs to the UPF0302 family
HYE74_RS08350	COG0457	Tetratricopeptide repeat
HYE74_RS08355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYE74_RS08360	COG0287	Prephenate dehydrogenase
HYE74_RS08365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HYE74_RS08370	COG4401	Chorismate mutase type I
HYE74_RS08375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HYE74_RS08380	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HYE74_RS08385	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HYE74_RS08390	COG0105	UTP biosynthetic process
HYE74_RS08395	COG0142	geranyltranstransferase activity
HYE74_RS08400	COG2226	methyltransferase
HYE74_RS08405	COG0142	geranyltranstransferase activity
HYE74_RS08415	COG0776	regulation of translation
HYE74_RS08420	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HYE74_RS08440	COG1160	GTP binding
HYE74_RS08455	COG0539	negative regulation of cytoplasmic translation
HYE74_RS08460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HYE74_RS08465	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HYE74_RS08470	COG2959	enzyme of heme biosynthesis
HYE74_RS08475	COG3409	Peptidoglycan-binding domain 1 protein
HYE74_RS08475	COG3773	Cell wall hydrolase
HYE74_RS08480	COG2339	peptidase activity
HYE74_RS08485	COG0492	ferredoxin-NADP+ reductase activity
HYE74_RS08490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYE74_RS08500	COG1408	metallophosphoesterase
HYE74_RS08515	COG3546	catalase activity
HYE74_RS08530	COG1266	CAAX protease self-immunity
HYE74_RS08535	COG0514	ATP-dependent DNA helicase (RecQ)
HYE74_RS08545	COG1141	Ferredoxin
HYE74_RS08550	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HYE74_RS08555	COG1196	nuclear chromosome segregation
HYE74_RS08555	COG0739	heme binding
HYE74_RS08555	COG0741	lytic transglycosylase activity
HYE74_RS08560	COG5002	protein histidine kinase activity
HYE74_RS08565	COG0745	RESPONSE REGULATOR receiver
HYE74_RS08570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYE74_RS08575	COG1333	cytochrome c biogenesis protein
HYE74_RS08580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYE74_RS08585	COG1187	pseudouridine synthase activity
HYE74_RS08590	COG0700	Nucleoside recognition
HYE74_RS08595	COG2715	membrane protein required for spore maturation
HYE74_RS08600	COG1686	Belongs to the peptidase S11 family
HYE74_RS08605	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HYE74_RS08630	COG0697	spore germination
HYE74_RS08650	COG1191	sigma factor activity
HYE74_RS08665	COG1686	Belongs to the peptidase S11 family
HYE74_RS08670	COG4974	Belongs to the 'phage' integrase family
HYE74_RS08680	COG0735	belongs to the Fur family
HYE74_RS08685	COG1300	Membrane
HYE74_RS08690	COG1379	DNA repair
HYE74_RS08705	COG0667	Aldo Keto reductase
HYE74_RS08715	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HYE74_RS08720	COG3853	Toxic anion resistance protein (TelA)
HYE74_RS08725	COG1073	alpha beta
HYE74_RS08730	COG3858	chitin binding
HYE74_RS08730	COG1388	LysM domain
HYE74_RS08740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYE74_RS08745	COG0300	oxidoreductase activity
HYE74_RS08750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYE74_RS08760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HYE74_RS08765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYE74_RS08775	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYE74_RS08785	COG1376	ErfK ybiS ycfS ynhG family protein
HYE74_RS08795	COG1105	Belongs to the carbohydrate kinase PfkB family
HYE74_RS08800	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYE74_RS08805	COG0022	dehydrogenase e1 component
HYE74_RS08810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HYE74_RS08815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYE74_RS08825	COG3829	transcription factor binding
HYE74_RS08825	COG3290	protein histidine kinase activity
HYE74_RS08835	COG0584	glycerophosphoryl diester phosphodiesterase
HYE74_RS08840	COG0745	RESPONSE REGULATOR receiver
HYE74_RS08845	COG0750	zinc metalloprotease
HYE74_RS08850	COG0497	DNA recombination
HYE74_RS08860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HYE74_RS08865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HYE74_RS08880	COG1570	exodeoxyribonuclease VII activity
HYE74_RS08895	COG1302	Protein conserved in bacteria
HYE74_RS08900	COG0439	Biotin carboxylase
HYE74_RS08905	COG0511	ligase activity, forming carbon-carbon bonds
HYE74_RS08945	COG3854	ATPases associated with a variety of cellular activities
HYE74_RS08950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HYE74_RS08955	COG0006	proline dipeptidase activity
HYE74_RS08960	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HYE74_RS08970	COG3872	metal-dependent enzyme
HYE74_RS08980	COG1752	Esterase of the alpha-beta hydrolase superfamily
HYE74_RS08990	COG3327	negative regulation of DNA-templated transcription, initiation
HYE74_RS08995	COG0183	Belongs to the thiolase family
HYE74_RS09000	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYE74_RS09005	COG1012	belongs to the aldehyde dehydrogenase family
HYE74_RS09010	COG1024	Enoyl-CoA hydratase
HYE74_RS09020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYE74_RS09025	COG0095	Lipoate-protein ligase
HYE74_RS09030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYE74_RS09035	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HYE74_RS09045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HYE74_RS09050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYE74_RS09065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HYE74_RS09090	COG4537	Required for transformation and DNA binding
HYE74_RS09095	COG1459	type II secretion system
HYE74_RS09100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HYE74_RS09115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYE74_RS09125	COG1940	carbohydrate kinase activity
HYE74_RS09130	COG4483	Protein conserved in bacteria
HYE74_RS09135	COG0705	Rhomboid family
HYE74_RS09135	COG0457	Tetratricopeptide repeat
HYE74_RS09145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HYE74_RS09155	COG0768	penicillin binding
HYE74_RS09160	COG0477	Major facilitator Superfamily
HYE74_RS09165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HYE74_RS09175	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HYE74_RS09180	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HYE74_RS09185	COG0735	belongs to the Fur family
HYE74_RS09190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYE74_RS09195	COG1121	(ABC) transporter
HYE74_RS09205	COG3883	PFAM NLP P60 protein
HYE74_RS09205	COG0791	NLP P60 protein
HYE74_RS09210	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HYE74_RS09215	COG0513	Belongs to the DEAD box helicase family
HYE74_RS09225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HYE74_RS09230	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYE74_RS09235	COG2384	SAM-dependent methyltransferase
HYE74_RS09240	COG2010	Cytochrome c
HYE74_RS09250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HYE74_RS09255	COG0358	DNA primase activity
HYE74_RS09265	COG0517	IMP dehydrogenase activity
HYE74_RS09270	COG1381	Involved in DNA repair and RecF pathway recombination
HYE74_RS09285	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HYE74_RS09290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HYE74_RS09295	COG1480	7TM receptor with intracellular HD hydrolase
HYE74_RS09300	COG1702	phosphate starvation-inducible protein PhoH
HYE74_RS09315	COG1610	YqeY-like protein
HYE74_RS09335	COG1283	sodium-dependent phosphate transmembrane transporter activity
HYE74_RS09340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HYE74_RS09345	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYE74_RS09350	COG2264	protein methyltransferase activity
HYE74_RS09360	COG0443	Heat shock 70 kDa protein
HYE74_RS09365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HYE74_RS09375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYE74_RS09380	COG0481	GTPase activity
HYE74_RS09385	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYE74_RS09390	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HYE74_RS09395	COG0268	Binds directly to 16S ribosomal RNA
HYE74_RS09400	COG1466	dna polymerase III delta subunit
HYE74_RS09410	COG0658	competence protein
HYE74_RS09410	COG2333	competence protein COMEC
HYE74_RS09415	COG2131	deaminase
HYE74_RS09420	COG1555	photosystem II stabilization
HYE74_RS09420	COG1596	polysaccharide export
HYE74_RS09425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HYE74_RS09430	COG2226	methyltransferase
HYE74_RS09435	COG0799	negative regulation of ribosome biogenesis
HYE74_RS09440	COG1713	HD superfamily hydrolase involved in NAD metabolism
HYE74_RS09445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HYE74_RS09450	COG1534	Rna-binding protein
HYE74_RS09460	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HYE74_RS09465	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HYE74_RS09470	COG0247	lactate metabolic process
HYE74_RS09475	COG0277	FAD linked oxidase domain protein
HYE74_RS09480	COG3835	regulator
HYE74_RS09485	COG2132	Multicopper oxidase
HYE74_RS09490	COG0071	Belongs to the small heat shock protein (HSP20) family
HYE74_RS09500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYE74_RS09510	COG1704	LemA family
HYE74_RS09540	COG1183	phosphatidylcholine synthase activity
HYE74_RS09550	COG3634	alkyl hydroperoxide reductase activity
HYE74_RS09555	COG0450	alkyl hydroperoxide reductase
HYE74_RS09585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYE74_RS09590	COG0572	uridine kinase
HYE74_RS09595	COG4122	O-methyltransferase activity
HYE74_RS09600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYE74_RS09605	COG3906	Belongs to the UPF0473 family
HYE74_RS09610	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HYE74_RS09615	COG4472	Bacterial protein of unknown function (DUF965)
HYE74_RS09620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HYE74_RS09625	COG0628	permease
HYE74_RS09645	COG1522	sequence-specific DNA binding
HYE74_RS09655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYE74_RS09665	COG0482	sulfurtransferase activity
HYE74_RS09670	COG1104	cysteine desulfurase activity
HYE74_RS09675	COG1959	2 iron, 2 sulfur cluster binding
HYE74_RS09690	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS09695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYE74_RS09700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYE74_RS09705	COG0385	Bile acid
HYE74_RS09715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HYE74_RS09720	COG0124	histidyl-tRNA synthetase
HYE74_RS09730	COG4991	sh3 domain protein
HYE74_RS09730	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYE74_RS09730	COG3103	Sh3 type 3 domain protein
HYE74_RS09735	COG2814	Major facilitator Superfamily
HYE74_RS09740	COG1566	PFAM secretion protein HlyD family protein
HYE74_RS09745	COG1846	Transcriptional regulator
HYE74_RS09750	COG1490	D-aminoacyl-tRNA deacylase activity
HYE74_RS09755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYE74_RS09760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HYE74_RS09765	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HYE74_RS09765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYE74_RS09770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYE74_RS09770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HYE74_RS09780	COG2244	polysaccharide biosynthetic process
HYE74_RS09785	COG2323	membrane
HYE74_RS09795	COG1862	Preprotein translocase
HYE74_RS09800	COG0343	queuine tRNA-ribosyltransferase activity
HYE74_RS09805	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HYE74_RS09825	COG0217	transcriptional regulatory protein
HYE74_RS09835	COG1388	LysM domain
HYE74_RS09840	COG1827	regulation of RNA biosynthetic process
HYE74_RS09845	COG0077	Prephenate dehydratase
HYE74_RS09850	COG4492	Belongs to the UPF0735 family
HYE74_RS09855	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HYE74_RS09860	COG3290	protein histidine kinase activity
HYE74_RS09865	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HYE74_RS09870	COG2868	ribosomal protein
HYE74_RS09875	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HYE74_RS09880	COG1530	ribonuclease E activity
HYE74_RS09885	COG1994	Peptidase M50
HYE74_RS09895	COG2894	cell division
HYE74_RS09900	COG0850	regulation of cytokinetic process
HYE74_RS09910	COG1792	Involved in formation and maintenance of cell shape
HYE74_RS09915	COG1077	Cell shape determining protein MreB Mrl
HYE74_RS09920	COG2003	Belongs to the UPF0758 family
HYE74_RS09930	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HYE74_RS09950	COG0285	dihydrofolate synthase activity
HYE74_RS09965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HYE74_RS09970	COG1388	LysM domain
HYE74_RS09975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HYE74_RS09980	COG0113	porphobilinogen synthase activity
HYE74_RS09990	COG0181	hydroxymethylbilane synthase activity
HYE74_RS09995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HYE74_RS10010	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HYE74_RS10015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HYE74_RS10020	COG1067	ATP-dependent peptidase activity
HYE74_RS10020	COG0470	DNA polymerase III
HYE74_RS10030	COG0544	peptidyl-prolyl cis-trans isomerase activity
HYE74_RS10035	COG1477	protein flavinylation
HYE74_RS10035	COG0457	Tetratricopeptide repeat
HYE74_RS10060	COG0622	Phosphoesterase
HYE74_RS10065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HYE74_RS10070	COG5401	PFAM Sporulation and spore germination
HYE74_RS10080	COG5577	PFAM Coat F domain
HYE74_RS10085	COG1063	alcohol dehydrogenase
HYE74_RS10090	COG5577	PFAM Coat F domain
HYE74_RS10105	COG1846	Transcriptional regulator
HYE74_RS10130	COG2197	response regulator
HYE74_RS10135	COG0824	Thioesterase
HYE74_RS10140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HYE74_RS10145	COG1053	succinate dehydrogenase
HYE74_RS10150	COG2009	succinate dehydrogenase
HYE74_RS10155	COG1719	4-vinyl reductase, 4VR
HYE74_RS10165	COG0322	excinuclease ABC activity
HYE74_RS10170	COG3118	belongs to the thioredoxin family
HYE74_RS10175	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HYE74_RS10180	COG2086	electron transfer activity
HYE74_RS10185	COG1024	Enoyl-CoA hydratase
HYE74_RS10190	COG1309	transcriptional regulator
HYE74_RS10195	COG0318	PFAM AMP-dependent synthetase and ligase
HYE74_RS10200	COG1193	negative regulation of DNA recombination
HYE74_RS10205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HYE74_RS10205	COG1796	DNA polymerase
HYE74_RS10210	COG1286	toxin biosynthetic process
HYE74_RS10215	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HYE74_RS10225	COG0789	Transcriptional regulator
HYE74_RS10225	COG4978	Transcriptional regulator
HYE74_RS10235	COG0072	phenylalanine-tRNA ligase activity
HYE74_RS10235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYE74_RS10240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HYE74_RS10245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYE74_RS10270	COG1695	Transcriptional regulator
HYE74_RS10290	COG0431	NADPH-dependent FMN reductase
HYE74_RS10325	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HYE74_RS10335	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HYE74_RS10345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HYE74_RS10355	COG1484	DNA-dependent DNA replication
HYE74_RS10360	COG3611	Membrane attachment protein
HYE74_RS10365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HYE74_RS10390	COG4608	Belongs to the ABC transporter superfamily
HYE74_RS10395	COG0444	Belongs to the ABC transporter superfamily
HYE74_RS10400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYE74_RS10405	COG0601	transmembrane transport
HYE74_RS10410	COG0747	negative chemotaxis
HYE74_RS10415	COG1473	amidohydrolase
HYE74_RS10425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HYE74_RS10430	COG0237	dephospho-CoA kinase activity
HYE74_RS10435	COG1971	Probably functions as a manganese efflux pump
HYE74_RS10440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYE74_RS10445	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYE74_RS10445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HYE74_RS10450	COG0039	L-malate dehydrogenase activity
HYE74_RS10455	COG0538	isocitrate dehydrogenase activity
HYE74_RS10460	COG0372	Belongs to the citrate synthase family
HYE74_RS10465	COG2707	UPF0756 membrane protein
HYE74_RS10470	COG0628	permease
HYE74_RS10480	COG0205	6-phosphofructokinase activity
HYE74_RS10485	COG0825	malonyl-CoA metabolic process
HYE74_RS10490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HYE74_RS10495	COG0281	malic enzyme
HYE74_RS10500	COG0587	DNA-directed DNA polymerase activity
HYE74_RS10515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HYE74_RS10525	COG4109	DRTGG domain
HYE74_RS10530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HYE74_RS10535	COG0006	proline dipeptidase activity
HYE74_RS10545	COG0589	response to stress
HYE74_RS10555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYE74_RS10560	COG0827	DNA restriction-modification system
HYE74_RS10565	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HYE74_RS10570	COG3874	Sporulation protein YtfJ
HYE74_RS10580	COG1714	RDD family
HYE74_RS10585	COG0616	signal peptide processing
HYE74_RS10590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYE74_RS10600	COG0301	tRNA thio-modification
HYE74_RS10605	COG1104	cysteine desulfurase activity
HYE74_RS10610	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HYE74_RS10615	COG1309	transcriptional regulator
HYE74_RS10620	COG1956	GAF domain-containing protein
HYE74_RS10625	COG2199	diguanylate cyclase activity
HYE74_RS10625	COG2203	Gaf domain
HYE74_RS10630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HYE74_RS10635	COG0506	proline dehydrogenase activity
HYE74_RS10640	COG1012	belongs to the aldehyde dehydrogenase family
HYE74_RS10645	COG3290	protein histidine kinase activity
HYE74_RS10645	COG3829	transcription factor binding
HYE74_RS10655	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HYE74_RS10670	COG3383	formate dehydrogenase (NAD+) activity
HYE74_RS10675	COG2427	Protein of unknown function (DUF1641)
HYE74_RS10680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HYE74_RS10685	COG0315	cyclic pyranopterin monophosphate synthase activity
HYE74_RS10690	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HYE74_RS10695	COG0314	molybdopterin synthase activity
HYE74_RS10700	COG1763	Mo-molybdopterin cofactor biosynthetic process
HYE74_RS10705	COG0303	'Molybdopterin
HYE74_RS10720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYE74_RS10725	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HYE74_RS10730	COG4149	molybdate abc transporter
HYE74_RS10740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYE74_RS10745	COG0454	-acetyltransferase
HYE74_RS10750	COG0517	IMP dehydrogenase activity
HYE74_RS10755	COG0123	including yeast histone deacetylase and acetoin utilization protein
HYE74_RS10765	COG1605	Chorismate mutase
HYE74_RS10765	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HYE74_RS10770	COG4980	gas vesicle protein
HYE74_RS10780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYE74_RS10785	COG1674	ftsk spoiiie
HYE74_RS10795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYE74_RS10800	COG4848	Belongs to the UPF0354 family
HYE74_RS10805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYE74_RS10810	COG2208	phosphoserine phosphatase activity
HYE74_RS10815	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HYE74_RS10845	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HYE74_RS10850	COG1363	Peptidase, m42
HYE74_RS10855	COG5584	Small secreted protein
HYE74_RS10860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYE74_RS10865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYE74_RS10900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HYE74_RS10905	COG1349	DNA-binding transcription factor activity
HYE74_RS10910	COG2244	polysaccharide biosynthetic process
HYE74_RS10930	COG0495	leucyl-tRNA aminoacylation
HYE74_RS10935	COG2814	Major facilitator Superfamily
HYE74_RS10945	COG0275	rRNA processing
HYE74_RS10960	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HYE74_RS10965	COG0367	asparagine synthase
HYE74_RS10970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HYE74_RS10975	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HYE74_RS10985	COG1506	peptidase
HYE74_RS10990	COG0655	NAD(P)H dehydrogenase (quinone) activity
HYE74_RS10995	COG1070	Carbohydrate kinase
HYE74_RS11000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYE74_RS11005	COG1116	anion transmembrane transporter activity
HYE74_RS11010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYE74_RS11025	COG0783	Belongs to the Dps family
HYE74_RS11030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HYE74_RS11040	COG0803	Belongs to the bacterial solute-binding protein 9 family
HYE74_RS11050	COG4948	Mandelate Racemase Muconate Lactonizing
HYE74_RS11055	COG0318	PFAM AMP-dependent synthetase and ligase
HYE74_RS11060	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HYE74_RS11065	COG0596	Alpha beta hydrolase
HYE74_RS11070	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HYE74_RS11075	COG1169	isochorismate synthase
HYE74_RS11080	COG1575	Belongs to the MenA family. Type 1 subfamily
HYE74_RS11205	COG0577	efflux transmembrane transporter activity
HYE74_RS11205	COG1136	(ABC) transporter
HYE74_RS11225	COG1285	pathogenesis
HYE74_RS11240	COG2217	Heavy metal translocating P-type atpase
HYE74_RS11245	COG2608	mercury ion transmembrane transporter activity
HYE74_RS11255	COG1522	sequence-specific DNA binding
HYE74_RS11275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYE74_RS11295	COG0726	polysaccharide deacetylase
HYE74_RS11325	COG0038	chloride channel
HYE74_RS11335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HYE74_RS11335	COG0425	Belongs to the sulfur carrier protein TusA family
HYE74_RS11340	COG1937	Protein conserved in bacteria
HYE74_RS11345	COG1525	nuclease
HYE74_RS11350	COG2190	(PTS) system
HYE74_RS11360	COG2160	L-arabinose isomerase activity
HYE74_RS11365	COG4214	carbohydrate transport
HYE74_RS11375	COG4213	ABC transporter substrate-binding protein
HYE74_RS11380	COG1609	Transcriptional regulator
HYE74_RS11385	COG2160	L-arabinose isomerase activity
HYE74_RS11390	COG0235	Class ii aldolase
HYE74_RS11405	COG1609	Transcriptional regulator
HYE74_RS11410	COG0840	transmembrane signaling receptor activity
HYE74_RS11425	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS11430	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HYE74_RS11445	COG1012	belongs to the aldehyde dehydrogenase family
HYE74_RS11465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HYE74_RS11475	COG2155	Conserved Protein
HYE74_RS11490	COG1098	S1 RNA binding domain
HYE74_RS11500	COG1902	pentaerythritol trinitrate reductase activity
HYE74_RS11505	COG0656	L-ascorbic acid biosynthetic process
HYE74_RS11525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYE74_RS11540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYE74_RS11550	COG0492	ferredoxin-NADP+ reductase activity
HYE74_RS11575	COG2814	Major facilitator Superfamily
HYE74_RS11580	COG2050	protein possibly involved in aromatic compounds catabolism
HYE74_RS11590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYE74_RS11600	COG0697	spore germination
HYE74_RS11610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HYE74_RS11615	COG3584	3D domain protein
HYE74_RS11625	COG1252	NADH dehydrogenase
HYE74_RS11630	COG0492	ferredoxin-NADP+ reductase activity
HYE74_RS11655	COG0316	Belongs to the HesB IscA family
HYE74_RS11660	COG4837	Protein of unknown function (DUF1462)
HYE74_RS11665	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HYE74_RS11670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HYE74_RS11675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HYE74_RS11680	COG0647	UMP catabolic process
HYE74_RS11685	COG2445	Protein of unknown function DUF86
HYE74_RS11690	COG4470	Protein conserved in bacteria
HYE74_RS11695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HYE74_RS11700	COG0739	heme binding
HYE74_RS11710	COG3377	Domain of unknown function (DUF1805)
HYE74_RS11715	COG0737	Belongs to the 5'-nucleotidase family
HYE74_RS11720	COG0719	Fe-S assembly protein
HYE74_RS11725	COG0822	iron-sulfur transferase activity
HYE74_RS11730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYE74_RS11735	COG0719	Fe-S assembly protein
HYE74_RS11740	COG0396	ATPase activity
HYE74_RS11750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYE74_RS11755	COG0509	glycine decarboxylation via glycine cleavage system
HYE74_RS11760	COG1393	Belongs to the ArsC family
HYE74_RS11765	COG1960	acyl-CoA dehydrogenase activity
HYE74_RS11770	COG0183	Belongs to the thiolase family
HYE74_RS11775	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYE74_RS11775	COG1024	Enoyl-CoA hydratase
HYE74_RS11790	COG5577	PFAM Coat F domain
HYE74_RS11795	COG0772	Belongs to the SEDS family
HYE74_RS11800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HYE74_RS11815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYE74_RS11825	COG0753	catalase activity
HYE74_RS11830	COG0671	phosphoesterase, PA-phosphatase related
HYE74_RS11840	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYE74_RS11855	COG1595	DNA-templated transcription, initiation
HYE74_RS11860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HYE74_RS11875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HYE74_RS11885	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HYE74_RS11890	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS11895	COG2211	Major facilitator Superfamily
HYE74_RS11900	COG1904	glucuronate isomerase
HYE74_RS11905	COG2721	sulfolactate sulfo-lyase activity
HYE74_RS11910	COG0246	Mannitol dehydrogenase
HYE74_RS11920	COG0800	Aldolase
HYE74_RS11925	COG1414	Transcriptional regulator
HYE74_RS11945	COG0488	(ABC) transporter
HYE74_RS11975	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HYE74_RS11980	COG0732	type I restriction modification DNA specificity domain
HYE74_RS11985	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HYE74_RS12030	COG0557	exoribonuclease II activity
HYE74_RS12040	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HYE74_RS12045	COG0148	phosphopyruvate hydratase activity
HYE74_RS12050	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HYE74_RS12060	COG0126	phosphoglycerate kinase activity
HYE74_RS12080	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HYE74_RS12095	COG3383	formate dehydrogenase (NAD+) activity
HYE74_RS12105	COG0840	transmembrane signaling receptor activity
HYE74_RS12130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYE74_RS12145	COG4608	Belongs to the ABC transporter superfamily
HYE74_RS12150	COG0791	NLP P60 protein
HYE74_RS12155	COG4166	transmembrane transport
HYE74_RS12160	COG0444	Belongs to the ABC transporter superfamily
HYE74_RS12165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYE74_RS12170	COG0601	transmembrane transport
HYE74_RS12175	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HYE74_RS12185	COG0598	Magnesium transport protein CorA
HYE74_RS12195	COG2719	SpoVR family
HYE74_RS12200	COG3594	Acyltransferase
HYE74_RS12225	COG1392	Phosphate transport regulator
HYE74_RS12230	COG0306	phosphate transporter
HYE74_RS12245	COG2718	Belongs to the UPF0229 family
HYE74_RS12250	COG2766	serine protein kinase
HYE74_RS12255	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HYE74_RS12270	COG2095	MarC family integral membrane protein
HYE74_RS12280	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HYE74_RS12285	COG0596	Alpha beta hydrolase
HYE74_RS12290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYE74_RS12295	COG0765	amino acid transport
HYE74_RS12300	COG1126	abc transporter atp-binding protein
HYE74_RS12305	COG2116	formate transmembrane transporter activity
HYE74_RS12315	COG1882	Formate acetyltransferase
HYE74_RS12320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HYE74_RS12325	COG0431	NADPH-dependent FMN reductase
HYE74_RS12340	COG1131	(ABC) transporter
HYE74_RS12365	COG0745	RESPONSE REGULATOR receiver
HYE74_RS12370	COG3850	Histidine kinase
HYE74_RS12370	COG5002	protein histidine kinase activity
HYE74_RS12390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYE74_RS12395	COG1846	Transcriptional regulator
HYE74_RS12410	COG2271	Major facilitator Superfamily
HYE74_RS12415	COG0697	spore germination
HYE74_RS12435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYE74_RS12440	COG2323	membrane
HYE74_RS12545	COG3527	Alpha-acetolactate decarboxylase
HYE74_RS12550	COG0028	Belongs to the TPP enzyme family
HYE74_RS12555	COG0583	DNA-binding transcription factor activity
HYE74_RS12560	COG0735	belongs to the Fur family
HYE74_RS12575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HYE74_RS12580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYE74_RS12585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYE74_RS12590	COG1116	anion transmembrane transporter activity
HYE74_RS12595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HYE74_RS12600	COG2814	Major facilitator Superfamily
HYE74_RS12615	COG4129	membrane
HYE74_RS12620	COG1737	Transcriptional regulator
HYE74_RS12640	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HYE74_RS12650	COG1132	(ABC) transporter
HYE74_RS12655	COG3557	Belongs to the UPF0374 family
HYE74_RS12670	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS12675	COG0583	DNA-binding transcription factor activity
HYE74_RS12680	COG0067	glutamate synthase
HYE74_RS12680	COG0069	glutamate synthase activity
HYE74_RS12680	COG0070	glutamate synthase
HYE74_RS12685	COG0493	'glutamate synthase
HYE74_RS12690	COG1194	a g-specific adenine glycosylase
HYE74_RS12695	COG1988	membrane-bound metal-dependent
HYE74_RS12725	COG0159	tryptophan synthase activity
HYE74_RS12735	COG0133	tryptophan synthase activity
HYE74_RS12740	COG0134	indole-3-glycerol-phosphate synthase activity
HYE74_RS12745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HYE74_RS12750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HYE74_RS12750	COG0512	Glutamine amidotransferase of anthranilate synthase
HYE74_RS12760	COG0577	efflux transmembrane transporter activity
HYE74_RS12765	COG0577	efflux transmembrane transporter activity
HYE74_RS12765	COG1136	(ABC) transporter
HYE74_RS12770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYE74_RS12785	COG1131	(ABC) transporter
HYE74_RS12820	COG2197	response regulator
HYE74_RS12825	COG4585	Histidine kinase
HYE74_RS12830	COG1012	belongs to the aldehyde dehydrogenase family
HYE74_RS12830	COG1012	belongs to the aldehyde dehydrogenase family
HYE74_RS12840	COG0058	SHG alpha-glucan phosphorylase activity
HYE74_RS12845	COG0840	transmembrane signaling receptor activity
HYE74_RS12850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HYE74_RS12855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HYE74_RS12860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYE74_RS12875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HYE74_RS12880	COG0066	3-isopropylmalate dehydratase activity
HYE74_RS12885	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HYE74_RS12895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYE74_RS12900	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HYE74_RS12905	COG0440	acetolactate synthase activity
HYE74_RS12910	COG0028	Belongs to the TPP enzyme family
HYE74_RS12915	COG0129	dihydroxy-acid dehydratase activity
HYE74_RS12920	COG1114	Component of the transport system for branched-chain amino acids
HYE74_RS12925	COG1366	Belongs to the anti-sigma-factor antagonist family
HYE74_RS12955	COG0670	Belongs to the BI1 family
HYE74_RS12960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HYE74_RS12965	COG2223	nitrite transmembrane transporter activity
HYE74_RS12970	COG3279	Response regulator of the LytR AlgR family
HYE74_RS12975	COG3275	phosphorelay sensor kinase activity
HYE74_RS12980	COG0252	asparaginase activity
HYE74_RS12985	COG2132	Multicopper oxidase
HYE74_RS12990	COG1309	transcriptional regulator
HYE74_RS12995	COG1511	domain protein
HYE74_RS13030	COG0840	transmembrane signaling receptor activity
HYE74_RS13030	COG5278	phosphoserine phosphatase activity
HYE74_RS13035	COG3739	integral membrane protein
HYE74_RS13040	COG3655	Transcriptional regulator
HYE74_RS13060	COG1823	symporter activity
HYE74_RS13065	COG2839	Protein conserved in bacteria
HYE74_RS13090	COG0477	Major facilitator Superfamily
HYE74_RS13095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYE74_RS13100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYE74_RS13105	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HYE74_RS13110	COG0840	transmembrane signaling receptor activity
HYE74_RS13125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYE74_RS13130	COG1132	(ABC) transporter
HYE74_RS13135	COG1846	Transcriptional regulator
HYE74_RS13160	COG0798	PFAM Bile acid sodium symporter
HYE74_RS13270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HYE74_RS13275	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HYE74_RS13295	COG0387	Pfam Sodium calcium exchanger
HYE74_RS13300	COG0477	Major facilitator Superfamily
HYE74_RS13305	COG1295	ribonuclease BN
HYE74_RS13310	COG4840	Belongs to the UPF0435 family
HYE74_RS13315	COG0024	Methionine aminopeptidase
HYE74_RS13320	COG0693	protein deglycase activity
HYE74_RS13325	COG1360	Flagellar Motor Protein
HYE74_RS13330	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HYE74_RS13345	COG3189	MarR family transcriptional regulator
HYE74_RS13355	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HYE74_RS13360	COG1607	acyl-coa hydrolase
HYE74_RS13365	COG1077	Cell shape determining protein MreB Mrl
HYE74_RS13370	COG2268	Band 7 protein
HYE74_RS13375	COG1585	Membrane protein implicated in regulation of membrane protease activity
HYE74_RS13380	COG0626	cystathionine gamma-synthase activity
HYE74_RS13385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYE74_RS13390	COG1854	S-ribosylhomocysteine lyase activity
HYE74_RS13395	COG2226	methyltransferase
HYE74_RS13400	COG0288	reversible hydration of carbon dioxide
HYE74_RS13405	COG0860	N-Acetylmuramoyl-L-alanine amidase
HYE74_RS13415	COG2197	response regulator
HYE74_RS13435	COG4086	secreted protein
HYE74_RS13440	COG0737	Belongs to the 5'-nucleotidase family
HYE74_RS13455	COG3620	sequence-specific DNA binding
HYE74_RS13465	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HYE74_RS13470	COG1518	maintenance of DNA repeat elements
HYE74_RS13510	COG0778	Nitroreductase
HYE74_RS13520	COG1304	FMN binding
HYE74_RS13525	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HYE74_RS13530	COG0166	Belongs to the GPI family
HYE74_RS13535	COG0025	NhaP-type Na H and K H
HYE74_RS13540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HYE74_RS13540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HYE74_RS13540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYE74_RS13545	COG1349	DNA-binding transcription factor activity
HYE74_RS13555	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HYE74_RS13565	COG0561	phosphatase activity
HYE74_RS13590	COG2814	Major facilitator Superfamily
HYE74_RS13595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HYE74_RS13610	COG2357	RelA SpoT domain protein
HYE74_RS13615	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HYE74_RS13620	COG0667	Aldo Keto reductase
HYE74_RS13630	COG1846	Transcriptional regulator
HYE74_RS13650	COG2197	response regulator
HYE74_RS13655	COG4585	Histidine kinase
HYE74_RS13675	COG1673	EVE domain
HYE74_RS13685	COG2378	regulation of single-species biofilm formation
HYE74_RS13700	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HYE74_RS13705	COG1461	Dihydroxyacetone kinase
HYE74_RS13710	COG2376	Dihydroxyacetone kinase
HYE74_RS13780	COG0778	Nitroreductase
HYE74_RS13785	COG1113	amino acid transport
HYE74_RS13790	COG0730	response to heat
HYE74_RS13795	COG2233	PERMEase
HYE74_RS13805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HYE74_RS13830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYE74_RS13835	COG1024	Enoyl-CoA hydratase
HYE74_RS13840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYE74_RS13845	COG0511	ligase activity, forming carbon-carbon bonds
HYE74_RS13850	COG0439	Biotin carboxylase
HYE74_RS13855	COG1960	acyl-CoA dehydrogenase activity
HYE74_RS13860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYE74_RS13875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYE74_RS13880	COG3829	transcription factor binding
HYE74_RS13900	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HYE74_RS13905	COG0833	amino acid
HYE74_RS13940	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HYE74_RS13945	COG1140	nitrate reductase beta subunit
HYE74_RS13955	COG2181	nitrate reductase activity
HYE74_RS13960	COG2223	nitrite transmembrane transporter activity
HYE74_RS13965	COG3588	fructose-bisphosphate aldolase
HYE74_RS13975	COG0698	ribose 5-phosphate isomerase
HYE74_RS13980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYE74_RS13985	COG1494	fructose-1,6-bisphosphatase
HYE74_RS13995	COG2376	Dihydroxyacetone kinase
HYE74_RS14000	COG2814	Major facilitator Superfamily
HYE74_RS14005	COG1063	alcohol dehydrogenase
HYE74_RS14010	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS14040	COG0753	catalase activity
HYE74_RS14090	COG4268	DNA restriction-modification system
HYE74_RS14095	COG1401	restriction endodeoxyribonuclease activity
HYE74_RS14100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HYE74_RS14125	COG1280	lysine exporter protein (LysE YggA)
HYE74_RS14130	COG0386	Belongs to the glutathione peroxidase family
HYE74_RS14135	COG2190	(PTS) system
HYE74_RS14155	COG0582	viral genome integration into host DNA
HYE74_RS14180	COG1328	CTP reductase activity
HYE74_RS14190	COG1063	alcohol dehydrogenase
HYE74_RS14195	COG1929	Belongs to the glycerate kinase type-1 family
HYE74_RS14215	COG1879	ABC-type sugar transport system periplasmic component
HYE74_RS14220	COG1172	Belongs to the binding-protein-dependent transport system permease family
HYE74_RS14225	COG1129	ABC transporter
HYE74_RS14230	COG1869	D-ribose catabolic process
HYE74_RS14235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYE74_RS14240	COG1609	Transcriptional regulator
HYE74_RS14280	COG4549	nuclear export factor GLE1
HYE74_RS14285	COG2372	response to copper ion
HYE74_RS14285	COG1276	copper resistance
HYE74_RS14295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYE74_RS14300	COG1609	Transcriptional regulator
HYE74_RS14315	COG5002	protein histidine kinase activity
HYE74_RS14320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HYE74_RS14325	COG1278	Cold shock
HYE74_RS14330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYE74_RS14350	COG0697	spore germination
HYE74_RS14355	COG1472	Belongs to the glycosyl hydrolase 3 family
HYE74_RS14365	COG3876	Protein conserved in bacteria
HYE74_RS14380	COG1132	(ABC) transporter
HYE74_RS14385	COG1132	(ABC) transporter
HYE74_RS14405	COG0791	NLP P60 protein
HYE74_RS14405	COG1388	LysM domain
HYE74_RS14435	COG2272	Belongs to the type-B carboxylesterase lipase family
HYE74_RS14445	COG2814	Major facilitator Superfamily
HYE74_RS14450	COG1012	belongs to the aldehyde dehydrogenase family
HYE74_RS14455	COG3153	acetyltransferase
HYE74_RS14455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYE74_RS14500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYE74_RS14500	COG3153	acetyltransferase
HYE74_RS14505	COG5583	Uncharacterized small protein (DUF2292)
HYE74_RS14510	COG0431	NADPH-dependent FMN reductase
HYE74_RS14515	COG1116	anion transmembrane transporter activity
HYE74_RS14520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYE74_RS14525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYE74_RS14530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYE74_RS14560	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HYE74_RS14575	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HYE74_RS14585	COG2390	Transcriptional regulator
HYE74_RS14595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HYE74_RS14605	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HYE74_RS14620	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HYE74_RS14625	COG1984	allophanate hydrolase subunit 2
HYE74_RS14630	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HYE74_RS14635	COG2814	Major facilitator Superfamily
HYE74_RS14640	COG1764	response to oxidative stress
HYE74_RS14645	COG1126	abc transporter atp-binding protein
HYE74_RS14650	COG0765	amino acid transport
HYE74_RS14655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYE74_RS14665	COG0326	Molecular chaperone. Has ATPase activity
HYE74_RS14715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYE74_RS14730	COG1064	alcohol dehydrogenase
HYE74_RS14760	COG2814	Major facilitator Superfamily
HYE74_RS14765	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS14860	COG3716	PTS system mannose fructose sorbose family IID component
HYE74_RS14895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYE74_RS14900	COG1597	lipid kinase activity
HYE74_RS14925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYE74_RS14930	COG0154	amidase activity
HYE74_RS14935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYE74_RS14940	COG2224	Isocitrate lyase
HYE74_RS14945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HYE74_RS14950	COG4851	CamS sex pheromone cAM373 precursor
HYE74_RS14960	COG0210	DNA helicase
HYE74_RS14965	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HYE74_RS14970	COG4496	protein, YerC YecD
HYE74_RS14975	COG1470	cell adhesion involved in biofilm formation
HYE74_RS14990	COG0151	Belongs to the GarS family
HYE74_RS14995	COG0138	bifunctional purine biosynthesis protein purh
HYE74_RS15000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYE74_RS15005	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HYE74_RS15010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HYE74_RS15015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYE74_RS15020	COG0047	phosphoribosylformylglycinamidine synthase activity
HYE74_RS15025	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYE74_RS15035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HYE74_RS15040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HYE74_RS15045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HYE74_RS15055	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HYE74_RS15060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HYE74_RS15090	COG1301	dicarboxylic acid transport
HYE74_RS15100	COG3711	transcriptional antiterminator
HYE74_RS15105	COG2252	PERMEase
HYE74_RS15115	COG1132	(ABC) transporter
HYE74_RS15120	COG2814	Major facilitator Superfamily
HYE74_RS15125	COG2197	response regulator
HYE74_RS15130	COG3850	Histidine kinase
HYE74_RS15135	COG1131	(ABC) transporter
HYE74_RS15145	COG0842	Transport permease protein
HYE74_RS15160	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYE74_RS15170	COG2814	Major facilitator Superfamily
HYE74_RS15180	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HYE74_RS15190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYE74_RS15195	COG0824	Thioesterase
HYE74_RS15200	COG0318	PFAM AMP-dependent synthetase and ligase
HYE74_RS15205	COG0183	Belongs to the thiolase family
HYE74_RS15210	COG1024	Enoyl-CoA hydratase
HYE74_RS15215	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYE74_RS15220	COG2508	Transcriptional regulator
HYE74_RS15225	COG2814	Major facilitator Superfamily
HYE74_RS15230	COG0471	metal ion transport
HYE74_RS15235	COG2356	endonuclease I
HYE74_RS15260	COG1131	(ABC) transporter
HYE74_RS15265	COG1725	Transcriptional regulator
HYE74_RS15270	COG1695	Transcriptional regulator
HYE74_RS15275	COG3479	Phenolic acid decarboxylase
HYE74_RS15280	COG2910	NAD(P)H-binding
HYE74_RS15285	COG1959	2 iron, 2 sulfur cluster binding
HYE74_RS15290	COG1131	(ABC) transporter
HYE74_RS15305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYE74_RS15320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYE74_RS15325	COG1279	arginine transmembrane transporter activity
HYE74_RS15345	COG0425	Belongs to the sulfur carrier protein TusA family
HYE74_RS15350	COG2391	methyltransferase activity
HYE74_RS15360	COG1028	Short-chain dehydrogenase reductase Sdr
HYE74_RS15380	COG1120	ATPase activity
HYE74_RS15385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYE74_RS15400	COG3620	sequence-specific DNA binding
HYE74_RS15415	COG0519	Catalyzes the synthesis of GMP from XMP
HYE74_RS15415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HYE74_RS15420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYE74_RS15425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HYE74_RS15430	COG1335	isochorismatase
HYE74_RS15435	COG4948	Mandelate Racemase Muconate Lactonizing
HYE74_RS15445	COG0463	Glycosyl transferase, family 2
HYE74_RS15450	COG2246	polysaccharide biosynthetic process
HYE74_RS15455	COG0459	protein refolding
HYE74_RS15460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HYE74_RS15465	COG1266	CAAX protease self-immunity
HYE74_RS15475	COG0805	protein transport
HYE74_RS15480	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HYE74_RS15485	COG0488	(ABC) transporter
HYE74_RS15495	COG0456	acetyltransferase
HYE74_RS15500	COG1214	PFAM Peptidase M22, glycoprotease
HYE74_RS15505	COG0802	atpase or kinase
HYE74_RS15590	COG3091	SprT-like family
HYE74_RS15600	COG2183	response to ionizing radiation
HYE74_RS15605	COG2208	phosphoserine phosphatase activity
HYE74_RS15610	COG1191	sigma factor activity
HYE74_RS15615	COG2172	sigma factor antagonist activity
HYE74_RS15620	COG1366	Belongs to the anti-sigma-factor antagonist family
HYE74_RS15625	COG2208	phosphoserine phosphatase activity
HYE74_RS15630	COG2172	sigma factor antagonist activity
HYE74_RS15635	COG1366	Belongs to the anti-sigma-factor antagonist family
HYE74_RS15640	COG1366	Belongs to the anti-sigma-factor antagonist family
HYE74_RS15645	COG2337	Toxic component of a toxin-antitoxin (TA) module
HYE74_RS15650	COG0864	Transcriptional regulator
HYE74_RS15660	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HYE74_RS15665	COG0736	holo-[acyl-carrier-protein] synthase activity
HYE74_RS15670	COG0705	Rhomboid family
HYE74_RS15675	COG0513	Belongs to the DEAD box helicase family
HYE74_RS15685	COG1280	lysine exporter protein (LysE YggA)
HYE74_RS15690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYE74_RS15695	COG1609	Transcriptional regulator
HYE74_RS15700	COG0366	Alpha amylase catalytic
HYE74_RS15710	COG2182	Extracellular solute-binding protein
HYE74_RS15715	COG1175	transmembrane transport
HYE74_RS15720	COG3833	ABC-type maltose transport systems, permease component
HYE74_RS15730	COG1554	hydrolase, family 65, central catalytic
HYE74_RS15740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYE74_RS15745	COG1181	Belongs to the D-alanine--D-alanine ligase family
HYE74_RS15755	COG1253	flavin adenine dinucleotide binding
HYE74_RS15760	COG0789	Transcriptional regulator
HYE74_RS15765	COG1253	flavin adenine dinucleotide binding
HYE74_RS15785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HYE74_RS15795	COG0629	single-stranded DNA binding
HYE74_RS15805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HYE74_RS15810	COG4786	Flagellar basal body rod
HYE74_RS15815	COG4786	Flagellar basal body rod
HYE74_RS15820	COG1077	Cell shape determining protein MreB Mrl
HYE74_RS15825	COG1609	Transcriptional regulator
HYE74_RS15830	COG0739	heme binding
HYE74_RS15835	COG2385	sporulation resulting in formation of a cellular spore
HYE74_RS15840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYE74_RS15850	COG4836	Membrane
HYE74_RS15855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HYE74_RS15860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HYE74_RS15865	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HYE74_RS15870	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HYE74_RS15875	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYE74_RS15885	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HYE74_RS15890	COG0356	it plays a direct role in the translocation of protons across the membrane
HYE74_RS15900	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HYE74_RS15905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HYE74_RS15915	COG0698	ribose 5-phosphate isomerase
HYE74_RS15930	COG1971	Probably functions as a manganese efflux pump
HYE74_RS15935	COG0009	L-threonylcarbamoyladenylate synthase
HYE74_RS15950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HYE74_RS15960	COG1435	thymidine kinase activity
HYE74_RS15965	COG0254	rRNA binding
HYE74_RS15970	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HYE74_RS15975	COG1494	fructose-1,6-bisphosphatase
HYE74_RS15980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYE74_RS15985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYE74_RS15990	COG0191	fructose-bisphosphate aldolase activity
HYE74_RS15995	COG2204	response regulator
HYE74_RS16010	COG1131	(ABC) transporter
HYE74_RS16015	COG1725	Transcriptional regulator
HYE74_RS16020	COG0504	CTP synthase activity
HYE74_RS16025	COG3343	RNA polymerase activity
HYE74_RS16030	COG1136	(ABC) transporter
HYE74_RS16040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYE74_RS16040	COG1703	isobutyryl-CoA mutase activity
HYE74_RS16040	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HYE74_RS16045	COG1309	transcriptional regulator
HYE74_RS16050	COG1960	acyl-CoA dehydrogenase activity
HYE74_RS16055	COG1960	acyl-CoA dehydrogenase activity
HYE74_RS16060	COG0183	Belongs to the thiolase family
HYE74_RS16065	COG2181	nitrate reductase activity
HYE74_RS16065	COG0247	lactate metabolic process
HYE74_RS16070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYE74_RS16075	COG0018	arginyl-trna synthetase
HYE74_RS16085	COG0010	Belongs to the arginase family
HYE74_RS16090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HYE74_RS16100	COG1994	Peptidase M50
HYE74_RS16110	COG3465	dGTPase activity
HYE74_RS16115	COG1078	dGTPase activity
HYE74_RS16125	COG0095	Lipoate-protein ligase
HYE74_RS16135	COG0280	phosphate acetyltransferase
HYE74_RS16140	COG3253	May function as heme-dependent peroxidase
HYE74_RS16150	COG2363	Small membrane protein
HYE74_RS16160	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HYE74_RS16195	COG4555	ABC transporter
HYE74_RS16210	COG0351	phosphomethylpyrimidine kinase
HYE74_RS16225	COG0561	phosphatase activity
HYE74_RS16230	COG0514	ATP-dependent DNA helicase (RecQ)
HYE74_RS16235	COG1785	Belongs to the alkaline phosphatase family
HYE74_RS16240	COG1737	Transcriptional regulator
HYE74_RS16255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HYE74_RS16265	COG1346	cytolysis
HYE74_RS16270	COG1380	Effector of murein hydrolase LrgA
HYE74_RS16275	COG0583	DNA-binding transcription factor activity
HYE74_RS16280	COG0367	asparagine synthase
HYE74_RS16300	COG2966	Psort location CytoplasmicMembrane, score
HYE74_RS16305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYE74_RS16310	COG1966	Carbon starvation protein
HYE74_RS16320	COG3275	phosphorelay sensor kinase activity
HYE74_RS16325	COG1464	Belongs to the NlpA lipoprotein family
HYE74_RS16330	COG2011	ABC-type metal ion transport system permease component
HYE74_RS16335	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYE74_RS16340	COG1119	ATPase activity
HYE74_RS16355	COG0534	Mate efflux family protein
HYE74_RS16360	COG1442	glycosyl transferase family 8
HYE74_RS16365	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYE74_RS16375	COG2814	Major facilitator Superfamily
HYE74_RS16390	COG0028	Belongs to the TPP enzyme family
HYE74_RS16395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HYE74_RS16400	COG1132	(ABC) transporter
HYE74_RS16410	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HYE74_RS16430	COG2188	Transcriptional regulator
HYE74_RS16435	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HYE74_RS16440	COG1366	Belongs to the anti-sigma-factor antagonist family
HYE74_RS16470	COG1126	abc transporter atp-binding protein
HYE74_RS16480	COG0765	amino acid transport
HYE74_RS16485	COG0579	oxidoreductase
HYE74_RS16490	COG0477	Major facilitator Superfamily
HYE74_RS16495	COG1131	(ABC) transporter
HYE74_RS16500	COG0842	Transport permease protein
HYE74_RS16505	COG4585	Histidine kinase
HYE74_RS16510	COG2197	response regulator
HYE74_RS16530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HYE74_RS16535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYE74_RS16540	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HYE74_RS16545	COG4853	Protein conserved in bacteria
HYE74_RS16550	COG4863	YycH protein
HYE74_RS16555	COG5002	protein histidine kinase activity
HYE74_RS16560	COG0745	RESPONSE REGULATOR receiver
HYE74_RS16575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HYE74_RS16580	COG0305	Participates in initiation and elongation during chromosome replication
HYE74_RS16585	COG0359	binds to the 23S rRNA
HYE74_RS16590	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HYE74_RS16600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HYE74_RS16610	COG0360	Binds together with S18 to 16S ribosomal RNA
HYE74_RS16615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HYE74_RS16620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYE74_RS16620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYE74_RS16625	COG0307	riboflavin synthase, alpha
HYE74_RS16630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYE74_RS16630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYE74_RS16635	COG0012	GTP binding
HYE74_RS16640	COG4481	Protein conserved in bacteria
HYE74_RS16645	COG0668	transmembrane transport
HYE74_RS16660	COG1475	DNA binding
HYE74_RS16665	COG1192	Involved in chromosome partitioning
HYE74_RS16670	COG1475	DNA binding
HYE74_RS16675	COG0357	Ribosomal RNA small subunit methyltransferase G
HYE74_RS16680	COG0445	tRNA wobble uridine modification
HYE74_RS16685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HYE74_RS16690	COG1847	R3H domain protein
HYE74_RS16695	COG0706	membrane insertase activity
HYE74_RS16700	COG0594	ribonuclease P activity
HYE74_RS16705	COG0230	Belongs to the bacterial ribosomal protein bL34 family