locus-tag	class	description
SB48_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SB48_RS00015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SB48_RS00020	COG0594	ribonuclease P activity
SB48_RS00025	COG0706	membrane insertase activity
SB48_RS00030	COG1847	R3H domain protein
SB48_RS00035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SB48_RS00040	COG0445	tRNA wobble uridine modification
SB48_RS00045	COG0357	Ribosomal RNA small subunit methyltransferase G
SB48_RS00050	COG1475	DNA binding
SB48_RS00060	COG1192	Involved in chromosome partitioning
SB48_RS00065	COG1475	DNA binding
SB48_RS00080	COG0668	transmembrane transport
SB48_RS00085	COG4481	Protein conserved in bacteria
SB48_RS00090	COG0012	GTP binding
SB48_RS00095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SB48_RS00095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SB48_RS00100	COG0307	riboflavin synthase, alpha
SB48_RS00105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SB48_RS00105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SB48_RS00110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SB48_RS00115	COG0360	Binds together with S18 to 16S ribosomal RNA
SB48_RS00125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SB48_RS00135	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SB48_RS00140	COG0359	binds to the 23S rRNA
SB48_RS00145	COG0305	Participates in initiation and elongation during chromosome replication
SB48_RS00150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SB48_RS00165	COG0745	RESPONSE REGULATOR receiver
SB48_RS00170	COG5002	protein histidine kinase activity
SB48_RS00175	COG4863	YycH protein
SB48_RS00180	COG4853	Protein conserved in bacteria
SB48_RS00185	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SB48_RS00190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SB48_RS00195	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SB48_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB48_RS00235	COG1280	lysine exporter protein (LysE YggA)
SB48_RS00280	COG2329	Antibiotic biosynthesis monooxygenase
SB48_RS00310	COG0732	type I restriction modification DNA specificity domain
SB48_RS00315	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SB48_RS00320	COG0579	oxidoreductase
SB48_RS00335	COG0765	amino acid transport
SB48_RS00345	COG1126	abc transporter atp-binding protein
SB48_RS00355	COG3457	Alanine racemase
SB48_RS00380	COG1126	abc transporter atp-binding protein
SB48_RS00385	COG0765	amino acid transport
SB48_RS00390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_RS00395	COG1366	Belongs to the anti-sigma-factor antagonist family
SB48_RS00400	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SB48_RS00405	COG2188	Transcriptional regulator
SB48_RS00425	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SB48_RS00435	COG1132	(ABC) transporter
SB48_RS00445	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SB48_RS00450	COG0028	Belongs to the TPP enzyme family
SB48_RS00470	COG2814	Major facilitator Superfamily
SB48_RS00475	COG2195	Cleaves the N-terminal amino acid of tripeptides
SB48_RS00480	COG1442	glycosyl transferase family 8
SB48_RS00485	COG0534	Mate efflux family protein
SB48_RS00500	COG1119	ATPase activity
SB48_RS00505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SB48_RS00510	COG2011	ABC-type metal ion transport system permease component
SB48_RS00515	COG1464	Belongs to the NlpA lipoprotein family
SB48_RS00520	COG3275	phosphorelay sensor kinase activity
SB48_RS00530	COG1966	Carbon starvation protein
SB48_RS00535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SB48_RS00540	COG2966	Psort location CytoplasmicMembrane, score
SB48_RS00565	COG0367	asparagine synthase
SB48_RS00570	COG0583	DNA-binding transcription factor activity
SB48_RS00575	COG1380	Effector of murein hydrolase LrgA
SB48_RS00580	COG1346	cytolysis
SB48_RS00585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SB48_RS00595	COG1737	Transcriptional regulator
SB48_RS00600	COG1785	Belongs to the alkaline phosphatase family
SB48_RS00605	COG0514	ATP-dependent DNA helicase (RecQ)
SB48_RS00610	COG0561	phosphatase activity
SB48_RS00625	COG0351	phosphomethylpyrimidine kinase
SB48_RS00640	COG1121	(ABC) transporter
SB48_RS00655	COG4555	ABC transporter
SB48_RS00685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SB48_RS00695	COG2363	Small membrane protein
SB48_RS00705	COG3253	May function as heme-dependent peroxidase
SB48_RS00710	COG0280	phosphate acetyltransferase
SB48_RS00720	COG0095	Lipoate-protein ligase
SB48_RS00735	COG1078	dGTPase activity
SB48_RS00740	COG3465	dGTPase activity
SB48_RS00750	COG1994	Peptidase M50
SB48_RS00760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SB48_RS00765	COG0010	Belongs to the arginase family
SB48_RS00775	COG0018	arginyl-trna synthetase
SB48_RS00780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SB48_RS00785	COG2181	nitrate reductase activity
SB48_RS00785	COG0247	lactate metabolic process
SB48_RS00790	COG0183	Belongs to the thiolase family
SB48_RS00795	COG1960	acyl-CoA dehydrogenase activity
SB48_RS00800	COG1960	acyl-CoA dehydrogenase activity
SB48_RS00805	COG1309	transcriptional regulator
SB48_RS00810	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SB48_RS00810	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SB48_RS00810	COG1703	isobutyryl-CoA mutase activity
SB48_RS00820	COG1136	(ABC) transporter
SB48_RS00830	COG3343	RNA polymerase activity
SB48_RS00835	COG0504	CTP synthase activity
SB48_RS00840	COG1725	Transcriptional regulator
SB48_RS00845	COG1131	(ABC) transporter
SB48_RS00860	COG2204	response regulator
SB48_RS00865	COG0191	fructose-bisphosphate aldolase activity
SB48_RS00870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SB48_RS00875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SB48_RS00880	COG1494	fructose-1,6-bisphosphatase
SB48_RS00885	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SB48_RS00890	COG0254	rRNA binding
SB48_RS00895	COG1435	thymidine kinase activity
SB48_RS00905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SB48_RS00920	COG0009	L-threonylcarbamoyladenylate synthase
SB48_RS00925	COG1971	Probably functions as a manganese efflux pump
SB48_RS00945	COG0698	ribose 5-phosphate isomerase
SB48_RS00955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SB48_RS00965	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SB48_RS00975	COG0356	it plays a direct role in the translocation of protons across the membrane
SB48_RS00980	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SB48_RS00990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SB48_RS00995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SB48_RS01000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SB48_RS01005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SB48_RS01010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SB48_RS01015	COG4836	Membrane
SB48_RS01025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SB48_RS01030	COG2385	sporulation resulting in formation of a cellular spore
SB48_RS01035	COG0739	heme binding
SB48_RS01040	COG1609	Transcriptional regulator
SB48_RS01045	COG1077	Cell shape determining protein MreB Mrl
SB48_RS01050	COG4786	Flagellar basal body rod
SB48_RS01055	COG4786	Flagellar basal body rod
SB48_RS01060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SB48_RS01065	COG0629	single-stranded DNA binding
SB48_RS01080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SB48_RS01095	COG1253	flavin adenine dinucleotide binding
SB48_RS01100	COG0789	Transcriptional regulator
SB48_RS01105	COG1253	flavin adenine dinucleotide binding
SB48_RS01120	COG1181	Belongs to the D-alanine--D-alanine ligase family
SB48_RS01125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SB48_RS01135	COG1554	hydrolase, family 65, central catalytic
SB48_RS01145	COG3833	ABC-type maltose transport systems, permease component
SB48_RS01150	COG1175	transmembrane transport
SB48_RS01155	COG2182	Extracellular solute-binding protein
SB48_RS01165	COG0366	Alpha amylase catalytic
SB48_RS01170	COG1609	Transcriptional regulator
SB48_RS01175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SB48_RS01185	COG1280	lysine exporter protein (LysE YggA)
SB48_RS01195	COG0513	Belongs to the DEAD box helicase family
SB48_RS01200	COG0705	Rhomboid family
SB48_RS01205	COG0736	holo-[acyl-carrier-protein] synthase activity
SB48_RS01210	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SB48_RS01220	COG0864	Transcriptional regulator
SB48_RS01225	COG2337	Toxic component of a toxin-antitoxin (TA) module
SB48_RS01235	COG1366	Belongs to the anti-sigma-factor antagonist family
SB48_RS01240	COG1366	Belongs to the anti-sigma-factor antagonist family
SB48_RS01245	COG2172	sigma factor antagonist activity
SB48_RS01250	COG2208	phosphoserine phosphatase activity
SB48_RS01255	COG1366	Belongs to the anti-sigma-factor antagonist family
SB48_RS01260	COG2172	sigma factor antagonist activity
SB48_RS01265	COG1191	sigma factor activity
SB48_RS01270	COG2208	phosphoserine phosphatase activity
SB48_RS01275	COG2183	response to ionizing radiation
SB48_RS01285	COG3091	SprT-like family
SB48_RS01370	COG0802	atpase or kinase
SB48_RS01375	COG1214	PFAM Peptidase M22, glycoprotease
SB48_RS01380	COG0456	acetyltransferase
SB48_RS01395	COG0488	(ABC) transporter
SB48_RS01400	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SB48_RS01405	COG0805	protein transport
SB48_RS01415	COG1266	CAAX protease self-immunity
SB48_RS01420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SB48_RS01425	COG0459	protein refolding
SB48_RS01430	COG2246	polysaccharide biosynthetic process
SB48_RS01435	COG0463	Glycosyl transferase, family 2
SB48_RS01445	COG4948	Mandelate Racemase Muconate Lactonizing
SB48_RS01450	COG1335	isochorismatase
SB48_RS01455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SB48_RS01460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SB48_RS01465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SB48_RS01465	COG0519	Catalyzes the synthesis of GMP from XMP
SB48_RS01480	COG3620	sequence-specific DNA binding
SB48_RS01500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB48_RS01505	COG1120	ATPase activity
SB48_RS01525	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS01535	COG2391	methyltransferase activity
SB48_RS01540	COG0425	Belongs to the sulfur carrier protein TusA family
SB48_RS01565	COG1959	2 iron, 2 sulfur cluster binding
SB48_RS01570	COG2910	NAD(P)H-binding
SB48_RS01575	COG3479	Phenolic acid decarboxylase
SB48_RS01580	COG1695	Transcriptional regulator
SB48_RS01585	COG1725	Transcriptional regulator
SB48_RS01590	COG1131	(ABC) transporter
SB48_RS01615	COG0471	metal ion transport
SB48_RS01625	COG0179	Fumarylacetoacetate (FAA) hydrolase
SB48_RS01635	COG2814	Major facilitator Superfamily
SB48_RS01640	COG2508	Transcriptional regulator
SB48_RS01645	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB48_RS01655	COG0183	Belongs to the thiolase family
SB48_RS01660	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_RS01665	COG0824	Thioesterase
SB48_RS01685	COG0179	Fumarylacetoacetate (FAA) hydrolase
SB48_RS01700	COG0842	Transport permease protein
SB48_RS01710	COG1131	(ABC) transporter
SB48_RS01715	COG3850	Histidine kinase
SB48_RS01720	COG2197	response regulator
SB48_RS01725	COG2814	Major facilitator Superfamily
SB48_RS01730	COG1132	(ABC) transporter
SB48_RS01740	COG2252	PERMEase
SB48_RS01745	COG3711	transcriptional antiterminator
SB48_RS01760	COG1301	dicarboxylic acid transport
SB48_RS01785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_RS01785	COG1263	PTS System
SB48_RS01800	COG2190	(PTS) system
SB48_RS01800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_RS01800	COG1263	PTS System
SB48_RS01805	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SB48_RS01810	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SB48_RS01820	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SB48_RS01825	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SB48_RS01830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SB48_RS01840	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SB48_RS01845	COG0047	phosphoribosylformylglycinamidine synthase activity
SB48_RS01850	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SB48_RS01855	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SB48_RS01860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SB48_RS01865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SB48_RS01870	COG0138	bifunctional purine biosynthesis protein purh
SB48_RS01875	COG0151	Belongs to the GarS family
SB48_RS01890	COG1470	cell adhesion involved in biofilm formation
SB48_RS01895	COG4496	protein, YerC YecD
SB48_RS01900	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SB48_RS01905	COG0210	DNA helicase
SB48_RS01910	COG0210	DNA helicase
SB48_RS01920	COG4851	CamS sex pheromone cAM373 precursor
SB48_RS01925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SB48_RS01930	COG2224	Isocitrate lyase
SB48_RS01935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SB48_RS01940	COG0154	amidase activity
SB48_RS01945	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SB48_RS01970	COG1597	lipid kinase activity
SB48_RS01975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SB48_RS02050	COG3716	PTS system mannose fructose sorbose family IID component
SB48_RS02090	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS02095	COG2814	Major facilitator Superfamily
SB48_RS02125	COG1064	alcohol dehydrogenase
SB48_RS02140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SB48_RS02215	COG0326	Molecular chaperone. Has ATPase activity
SB48_RS02225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_RS02230	COG0765	amino acid transport
SB48_RS02235	COG1126	abc transporter atp-binding protein
SB48_RS02240	COG1764	response to oxidative stress
SB48_RS02245	COG2814	Major facilitator Superfamily
SB48_RS02255	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SB48_RS02260	COG1984	allophanate hydrolase subunit 2
SB48_RS02265	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SB48_RS02280	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SB48_RS02290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SB48_RS02300	COG2390	Transcriptional regulator
SB48_RS02310	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SB48_RS02325	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SB48_RS02355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB48_RS02360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB48_RS02365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB48_RS02370	COG1116	anion transmembrane transporter activity
SB48_RS02375	COG0431	NADPH-dependent FMN reductase
SB48_RS02380	COG5583	Uncharacterized small protein (DUF2292)
SB48_RS02385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SB48_RS02385	COG3153	acetyltransferase
SB48_RS02425	COG1012	belongs to the aldehyde dehydrogenase family
SB48_RS02430	COG2814	Major facilitator Superfamily
SB48_RS02435	COG0154	amidase activity
SB48_RS02440	COG2272	Belongs to the type-B carboxylesterase lipase family
SB48_RS02460	COG0791	NLP P60 protein
SB48_RS02460	COG1388	LysM domain
SB48_RS02480	COG1132	(ABC) transporter
SB48_RS02485	COG1132	(ABC) transporter
SB48_RS02510	COG3876	Protein conserved in bacteria
SB48_RS02530	COG1472	Belongs to the glycosyl hydrolase 3 family
SB48_RS02535	COG0697	spore germination
SB48_RS02555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB48_RS02560	COG1278	Cold shock
SB48_RS02565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SB48_RS02570	COG5002	protein histidine kinase activity
SB48_RS02595	COG1609	Transcriptional regulator
SB48_RS02600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SB48_RS02610	COG1276	copper resistance
SB48_RS02610	COG2372	response to copper ion
SB48_RS02615	COG4549	nuclear export factor GLE1
SB48_RS02660	COG1609	Transcriptional regulator
SB48_RS02665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SB48_RS02670	COG1869	D-ribose catabolic process
SB48_RS02675	COG1129	ABC transporter
SB48_RS02680	COG1172	Belongs to the binding-protein-dependent transport system permease family
SB48_RS02685	COG1879	ABC-type sugar transport system periplasmic component
SB48_RS02690	COG2610	gluconate transmembrane transporter activity
SB48_RS02695	COG1929	Belongs to the glycerate kinase type-1 family
SB48_RS02700	COG3835	regulator
SB48_RS02705	COG1063	alcohol dehydrogenase
SB48_RS02715	COG1328	CTP reductase activity
SB48_RS02730	COG1301	dicarboxylic acid transport
SB48_RS02735	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS02750	COG0281	malic enzyme
SB48_RS02760	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SB48_RS02760	COG0517	IMP dehydrogenase activity
SB48_RS02765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_RS02765	COG1263	PTS System
SB48_RS02780	COG2190	(PTS) system
SB48_RS02785	COG0386	Belongs to the glutathione peroxidase family
SB48_RS02795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB48_RS02800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SB48_RS02805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB48_RS02810	COG1126	abc transporter atp-binding protein
SB48_RS02815	COG0765	amino acid transport
SB48_RS02820	COG0765	amino acid transport
SB48_RS02835	COG0454	-acetyltransferase
SB48_RS02840	COG0431	NADPH-dependent FMN reductase
SB48_RS02845	COG0583	DNA-binding transcription factor activity
SB48_RS02905	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SB48_RS02910	COG1401	restriction endodeoxyribonuclease activity
SB48_RS02915	COG4268	DNA restriction-modification system
SB48_RS02930	COG3588	fructose-bisphosphate aldolase
SB48_RS02935	COG2223	nitrite transmembrane transporter activity
SB48_RS02940	COG2181	nitrate reductase activity
SB48_RS02950	COG1140	nitrate reductase beta subunit
SB48_RS02955	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SB48_RS02995	COG0833	amino acid
SB48_RS03000	COG3829	transcription factor binding
SB48_RS03005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SB48_RS03010	COG1494	fructose-1,6-bisphosphatase
SB48_RS03015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SB48_RS03020	COG0698	ribose 5-phosphate isomerase
SB48_RS03035	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB48_RS03045	COG2271	Major facilitator Superfamily
SB48_RS03055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SB48_RS03065	COG2376	Dihydroxyacetone kinase
SB48_RS03075	COG1349	DNA-binding transcription factor activity
SB48_RS03090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SB48_RS03095	COG1960	acyl-CoA dehydrogenase activity
SB48_RS03100	COG0439	Biotin carboxylase
SB48_RS03105	COG0511	ligase activity, forming carbon-carbon bonds
SB48_RS03110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SB48_RS03115	COG1024	Enoyl-CoA hydratase
SB48_RS03120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SB48_RS03140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SB48_RS03150	COG2233	PERMEase
SB48_RS03160	COG0730	response to heat
SB48_RS03165	COG1113	amino acid transport
SB48_RS03170	COG0778	Nitroreductase
SB48_RS03180	COG2376	Dihydroxyacetone kinase
SB48_RS03185	COG1461	Dihydroxyacetone kinase
SB48_RS03190	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SB48_RS03195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SB48_RS03200	COG2357	RelA SpoT domain protein
SB48_RS03215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SB48_RS03220	COG2814	Major facilitator Superfamily
SB48_RS03235	COG0561	phosphatase activity
SB48_RS03250	COG0371	Dehydrogenase
SB48_RS03255	COG1349	DNA-binding transcription factor activity
SB48_RS03260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SB48_RS03260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SB48_RS03260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_RS03265	COG0025	NhaP-type Na H and K H
SB48_RS03270	COG0166	Belongs to the GPI family
SB48_RS03280	COG1304	FMN binding
SB48_RS03330	COG1518	maintenance of DNA repeat elements
SB48_RS03335	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SB48_RS03340	COG3620	sequence-specific DNA binding
SB48_RS03355	COG0737	Belongs to the 5'-nucleotidase family
SB48_RS03360	COG4086	secreted protein
SB48_RS03380	COG2197	response regulator
SB48_RS03395	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB48_RS03400	COG0288	reversible hydration of carbon dioxide
SB48_RS03405	COG2226	methyltransferase
SB48_RS03410	COG1854	S-ribosylhomocysteine lyase activity
SB48_RS03415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SB48_RS03420	COG0626	cystathionine gamma-synthase activity
SB48_RS03425	COG1585	Membrane protein implicated in regulation of membrane protease activity
SB48_RS03430	COG2268	Band 7 protein
SB48_RS03435	COG1077	Cell shape determining protein MreB Mrl
SB48_RS03440	COG1607	acyl-coa hydrolase
SB48_RS03445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SB48_RS03455	COG3189	MarR family transcriptional regulator
SB48_RS03465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SB48_RS03470	COG1360	Flagellar Motor Protein
SB48_RS03475	COG0693	protein deglycase activity
SB48_RS03480	COG0024	Methionine aminopeptidase
SB48_RS03485	COG4840	Belongs to the UPF0435 family
SB48_RS03490	COG1295	ribonuclease BN
SB48_RS03495	COG0477	Major facilitator Superfamily
SB48_RS03500	COG0387	Pfam Sodium calcium exchanger
SB48_RS03525	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SB48_RS03530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SB48_RS03540	COG1846	Transcriptional regulator
SB48_RS03545	COG1132	(ABC) transporter
SB48_RS03550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SB48_RS03570	COG0840	transmembrane signaling receptor activity
SB48_RS03575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SB48_RS03580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SB48_RS03585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SB48_RS03590	COG0477	Major facilitator Superfamily
SB48_RS03595	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
SB48_RS03615	COG2839	Protein conserved in bacteria
SB48_RS03620	COG1823	symporter activity
SB48_RS03635	COG3655	Transcriptional regulator
SB48_RS03640	COG3739	integral membrane protein
SB48_RS03645	COG0840	transmembrane signaling receptor activity
SB48_RS03645	COG5278	phosphoserine phosphatase activity
SB48_RS03680	COG1511	domain protein
SB48_RS03685	COG1309	transcriptional regulator
SB48_RS03690	COG2132	Multicopper oxidase
SB48_RS03695	COG0252	asparaginase activity
SB48_RS03700	COG3275	phosphorelay sensor kinase activity
SB48_RS03705	COG3279	Response regulator of the LytR AlgR family
SB48_RS03710	COG2223	nitrite transmembrane transporter activity
SB48_RS03715	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SB48_RS03720	COG0670	Belongs to the BI1 family
SB48_RS03725	COG2124	cytochrome p450
SB48_RS03735	COG1366	Belongs to the anti-sigma-factor antagonist family
SB48_RS03740	COG1114	Component of the transport system for branched-chain amino acids
SB48_RS03750	COG0129	dihydroxy-acid dehydratase activity
SB48_RS03755	COG0028	Belongs to the TPP enzyme family
SB48_RS03760	COG0440	acetolactate synthase activity
SB48_RS03765	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SB48_RS03770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SB48_RS03780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SB48_RS03785	COG0066	3-isopropylmalate dehydratase activity
SB48_RS03790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SB48_RS03805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SB48_RS03810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SB48_RS03815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SB48_RS03820	COG0840	transmembrane signaling receptor activity
SB48_RS03825	COG0058	SHG alpha-glucan phosphorylase activity
SB48_RS03840	COG1012	belongs to the aldehyde dehydrogenase family
SB48_RS03840	COG1012	belongs to the aldehyde dehydrogenase family
SB48_RS03855	COG2197	response regulator
SB48_RS03895	COG1131	(ABC) transporter
SB48_RS03915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SB48_RS03920	COG0577	efflux transmembrane transporter activity
SB48_RS03920	COG1136	(ABC) transporter
SB48_RS03925	COG0577	efflux transmembrane transporter activity
SB48_RS03935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SB48_RS03935	COG0512	Glutamine amidotransferase of anthranilate synthase
SB48_RS03940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SB48_RS03945	COG0134	indole-3-glycerol-phosphate synthase activity
SB48_RS03950	COG0133	tryptophan synthase activity
SB48_RS03960	COG0159	tryptophan synthase activity
SB48_RS03995	COG1194	a g-specific adenine glycosylase
SB48_RS04000	COG1988	membrane-bound metal-dependent
SB48_RS04010	COG1131	(ABC) transporter
SB48_RS04030	COG0493	'glutamate synthase
SB48_RS04035	COG0070	glutamate synthase
SB48_RS04035	COG0069	glutamate synthase activity
SB48_RS04035	COG0067	glutamate synthase
SB48_RS04040	COG0583	DNA-binding transcription factor activity
SB48_RS04045	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS04060	COG3557	Belongs to the UPF0374 family
SB48_RS04065	COG1132	(ABC) transporter
SB48_RS04075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SB48_RS04080	COG1263	PTS System
SB48_RS04080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_RS04085	COG1737	Transcriptional regulator
SB48_RS04105	COG2814	Major facilitator Superfamily
SB48_RS04110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB48_RS04115	COG1116	anion transmembrane transporter activity
SB48_RS04120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB48_RS04125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB48_RS04130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SB48_RS04150	COG0735	belongs to the Fur family
SB48_RS04155	COG0583	DNA-binding transcription factor activity
SB48_RS04160	COG0028	Belongs to the TPP enzyme family
SB48_RS04165	COG3527	Alpha-acetolactate decarboxylase
SB48_RS04275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB48_RS04290	COG0697	spore germination
SB48_RS04300	COG2271	Major facilitator Superfamily
SB48_RS04320	COG0577	efflux transmembrane transporter activity
SB48_RS04320	COG1136	(ABC) transporter
SB48_RS04340	COG1846	Transcriptional regulator
SB48_RS04360	COG4555	ABC transporter
SB48_RS04365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SB48_RS04370	COG3104	oligopeptide transport
SB48_RS04375	COG2188	Transcriptional regulator
SB48_RS04385	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SB48_RS04395	COG5002	protein histidine kinase activity
SB48_RS04395	COG3850	Histidine kinase
SB48_RS04400	COG0745	RESPONSE REGULATOR receiver
SB48_RS04435	COG1131	(ABC) transporter
SB48_RS04450	COG0431	NADPH-dependent FMN reductase
SB48_RS04455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SB48_RS04460	COG1882	Formate acetyltransferase
SB48_RS04490	COG2116	formate transmembrane transporter activity
SB48_RS04495	COG1126	abc transporter atp-binding protein
SB48_RS04500	COG0765	amino acid transport
SB48_RS04505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_RS04510	COG0596	Alpha beta hydrolase
SB48_RS04515	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SB48_RS04530	COG2095	MarC family integral membrane protein
SB48_RS04545	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SB48_RS04560	COG2766	serine protein kinase
SB48_RS04565	COG2718	Belongs to the UPF0229 family
SB48_RS04580	COG0306	phosphate transporter
SB48_RS04585	COG1392	Phosphate transport regulator
SB48_RS04610	COG3594	Acyltransferase
SB48_RS04615	COG2719	SpoVR family
SB48_RS04630	COG0598	Magnesium transport protein CorA
SB48_RS04640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SB48_RS04645	COG0601	transmembrane transport
SB48_RS04650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SB48_RS04655	COG0444	Belongs to the ABC transporter superfamily
SB48_RS04660	COG4166	transmembrane transport
SB48_RS04665	COG0791	NLP P60 protein
SB48_RS04670	COG4608	Belongs to the ABC transporter superfamily
SB48_RS04680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SB48_RS04710	COG0840	transmembrane signaling receptor activity
SB48_RS04720	COG3383	formate dehydrogenase (NAD+) activity
SB48_RS04735	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SB48_RS04755	COG0126	phosphoglycerate kinase activity
SB48_RS04765	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SB48_RS04770	COG0148	phosphopyruvate hydratase activity
SB48_RS04780	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SB48_RS04785	COG1647	Serine aminopeptidase, S33
SB48_RS04790	COG0557	exoribonuclease II activity
SB48_RS04855	COG1414	Transcriptional regulator
SB48_RS04860	COG0800	Aldolase
SB48_RS04870	COG0246	Mannitol dehydrogenase
SB48_RS04875	COG2721	sulfolactate sulfo-lyase activity
SB48_RS04880	COG1904	glucuronate isomerase
SB48_RS04885	COG2211	Major facilitator Superfamily
SB48_RS04890	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS04895	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SB48_RS04905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SB48_RS04925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SB48_RS04930	COG1595	DNA-templated transcription, initiation
SB48_RS04950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SB48_RS04960	COG0671	phosphoesterase, PA-phosphatase related
SB48_RS04965	COG0753	catalase activity
SB48_RS04970	COG2199	diguanylate cyclase activity
SB48_RS04970	COG2200	EAL domain
SB48_RS04970	COG2202	Pas domain
SB48_RS04980	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SB48_RS04990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB48_RS04995	COG0772	Belongs to the SEDS family
SB48_RS05000	COG5577	PFAM Coat F domain
SB48_RS05010	COG1024	Enoyl-CoA hydratase
SB48_RS05010	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB48_RS05015	COG0183	Belongs to the thiolase family
SB48_RS05020	COG1960	acyl-CoA dehydrogenase activity
SB48_RS05025	COG1393	Belongs to the ArsC family
SB48_RS05030	COG0509	glycine decarboxylation via glycine cleavage system
SB48_RS05035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB48_RS05050	COG0396	ATPase activity
SB48_RS05055	COG0719	Fe-S assembly protein
SB48_RS05060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SB48_RS05065	COG0822	iron-sulfur transferase activity
SB48_RS05070	COG0719	Fe-S assembly protein
SB48_RS05075	COG0737	Belongs to the 5'-nucleotidase family
SB48_RS05080	COG3377	Domain of unknown function (DUF1805)
SB48_RS05090	COG0739	heme binding
SB48_RS05095	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SB48_RS05100	COG4470	Protein conserved in bacteria
SB48_RS05105	COG2445	Protein of unknown function DUF86
SB48_RS05110	COG0647	UMP catabolic process
SB48_RS05115	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SB48_RS05120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SB48_RS05130	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SB48_RS05135	COG4837	Protein of unknown function (DUF1462)
SB48_RS05140	COG0316	Belongs to the HesB IscA family
SB48_RS05165	COG0492	ferredoxin-NADP+ reductase activity
SB48_RS05170	COG1252	NADH dehydrogenase
SB48_RS05180	COG3584	3D domain protein
SB48_RS05185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SB48_RS05195	COG0697	spore germination
SB48_RS05205	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SB48_RS05220	COG2050	protein possibly involved in aromatic compounds catabolism
SB48_RS05225	COG2814	Major facilitator Superfamily
SB48_RS05255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SB48_RS05275	COG0656	L-ascorbic acid biosynthetic process
SB48_RS05295	COG1098	S1 RNA binding domain
SB48_RS05310	COG2155	Conserved Protein
SB48_RS05320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SB48_RS05345	COG1012	belongs to the aldehyde dehydrogenase family
SB48_RS05365	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
SB48_RS05375	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS05390	COG0840	transmembrane signaling receptor activity
SB48_RS05395	COG1609	Transcriptional regulator
SB48_RS05410	COG4214	carbohydrate transport
SB48_RS05420	COG4213	ABC transporter substrate-binding protein
SB48_RS05425	COG1609	Transcriptional regulator
SB48_RS05430	COG2160	L-arabinose isomerase activity
SB48_RS05435	COG0235	Class ii aldolase
SB48_RS05450	COG2190	(PTS) system
SB48_RS05455	COG1525	nuclease
SB48_RS05465	COG1937	Protein conserved in bacteria
SB48_RS05470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SB48_RS05480	COG0038	chloride channel
SB48_RS05500	COG0726	polysaccharide deacetylase
SB48_RS05520	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SB48_RS05540	COG1522	sequence-specific DNA binding
SB48_RS05555	COG2608	mercury ion transmembrane transporter activity
SB48_RS05560	COG2217	Heavy metal translocating P-type atpase
SB48_RS05585	COG1285	pathogenesis
SB48_RS05710	COG1575	Belongs to the MenA family. Type 1 subfamily
SB48_RS05715	COG1169	isochorismate synthase
SB48_RS05720	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SB48_RS05725	COG0596	Alpha beta hydrolase
SB48_RS05730	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SB48_RS05735	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_RS05740	COG4948	Mandelate Racemase Muconate Lactonizing
SB48_RS05745	COG0803	Belongs to the bacterial solute-binding protein 9 family
SB48_RS05750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SB48_RS05755	COG0783	Belongs to the Dps family
SB48_RS05770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB48_RS05775	COG1116	anion transmembrane transporter activity
SB48_RS05780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB48_RS05785	COG1070	Carbohydrate kinase
SB48_RS05790	COG0655	NAD(P)H dehydrogenase (quinone) activity
SB48_RS05795	COG1506	peptidase
SB48_RS05805	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SB48_RS05810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SB48_RS05815	COG0367	asparagine synthase
SB48_RS05820	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SB48_RS05825	COG2267	carboxylic ester hydrolase activity
SB48_RS05835	COG0275	rRNA processing
SB48_RS05845	COG2814	Major facilitator Superfamily
SB48_RS05850	COG0495	leucyl-tRNA aminoacylation
SB48_RS05870	COG2244	polysaccharide biosynthetic process
SB48_RS05875	COG1349	DNA-binding transcription factor activity
SB48_RS05880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB48_RS05900	COG0510	thiamine kinase activity
SB48_RS05910	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SB48_RS05920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB48_RS05925	COG5584	Small secreted protein
SB48_RS05930	COG1363	Peptidase, m42
SB48_RS05935	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
SB48_RS05950	COG0784	Response regulator, receiver
SB48_RS05950	COG5002	protein histidine kinase activity
SB48_RS05960	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SB48_RS05965	COG2208	phosphoserine phosphatase activity
SB48_RS05970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB48_RS05975	COG4848	Belongs to the UPF0354 family
SB48_RS05980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB48_RS05990	COG1674	ftsk spoiiie
SB48_RS05995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SB48_RS06005	COG4980	gas vesicle protein
SB48_RS06010	COG1605	Chorismate mutase
SB48_RS06010	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SB48_RS06020	COG0123	including yeast histone deacetylase and acetoin utilization protein
SB48_RS06025	COG0517	IMP dehydrogenase activity
SB48_RS06030	COG0454	-acetyltransferase
SB48_RS06035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SB48_RS06045	COG4149	molybdate abc transporter
SB48_RS06050	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SB48_RS06055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SB48_RS06070	COG0303	'Molybdopterin
SB48_RS06075	COG1763	Mo-molybdopterin cofactor biosynthetic process
SB48_RS06080	COG0314	molybdopterin synthase activity
SB48_RS06085	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SB48_RS06090	COG0315	cyclic pyranopterin monophosphate synthase activity
SB48_RS06095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SB48_RS06100	COG2427	Protein of unknown function (DUF1641)
SB48_RS06105	COG3383	formate dehydrogenase (NAD+) activity
SB48_RS06110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SB48_RS06125	COG3290	protein histidine kinase activity
SB48_RS06125	COG3829	transcription factor binding
SB48_RS06130	COG1012	belongs to the aldehyde dehydrogenase family
SB48_RS06135	COG0506	proline dehydrogenase activity
SB48_RS06145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SB48_RS06155	COG2203	Gaf domain
SB48_RS06155	COG2199	diguanylate cyclase activity
SB48_RS06160	COG1956	GAF domain-containing protein
SB48_RS06165	COG1309	transcriptional regulator
SB48_RS06170	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SB48_RS06175	COG1104	cysteine desulfurase activity
SB48_RS06180	COG0301	tRNA thio-modification
SB48_RS06190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SB48_RS06195	COG0616	signal peptide processing
SB48_RS06200	COG1714	RDD family
SB48_RS06210	COG3874	Sporulation protein YtfJ
SB48_RS06215	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SB48_RS06220	COG0827	DNA restriction-modification system
SB48_RS06225	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SB48_RS06235	COG0589	response to stress
SB48_RS06245	COG0006	proline dipeptidase activity
SB48_RS06250	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SB48_RS06255	COG4109	DRTGG domain
SB48_RS06265	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SB48_RS06280	COG0587	DNA-directed DNA polymerase activity
SB48_RS06285	COG0281	malic enzyme
SB48_RS06290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SB48_RS06295	COG0825	malonyl-CoA metabolic process
SB48_RS06300	COG0205	6-phosphofructokinase activity
SB48_RS06310	COG0628	permease
SB48_RS06315	COG2707	UPF0756 membrane protein
SB48_RS06320	COG0372	Belongs to the citrate synthase family
SB48_RS06325	COG0538	isocitrate dehydrogenase activity
SB48_RS06330	COG0039	L-malate dehydrogenase activity
SB48_RS06340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SB48_RS06340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SB48_RS06345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SB48_RS06350	COG1971	Probably functions as a manganese efflux pump
SB48_RS06355	COG0237	dephospho-CoA kinase activity
SB48_RS06360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SB48_RS06365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SB48_RS06370	COG3611	Membrane attachment protein
SB48_RS06375	COG1484	DNA-dependent DNA replication
SB48_RS06385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SB48_RS06395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SB48_RS06405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SB48_RS06435	COG0431	NADPH-dependent FMN reductase
SB48_RS06455	COG1695	Transcriptional regulator
SB48_RS06465	COG2329	Antibiotic biosynthesis monooxygenase
SB48_RS06500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SB48_RS06505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SB48_RS06510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB48_RS06510	COG0072	phenylalanine-tRNA ligase activity
SB48_RS06520	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SB48_RS06525	COG1286	toxin biosynthetic process
SB48_RS06530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SB48_RS06530	COG1796	DNA polymerase
SB48_RS06535	COG1193	negative regulation of DNA recombination
SB48_RS06540	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_RS06545	COG1309	transcriptional regulator
SB48_RS06550	COG1024	Enoyl-CoA hydratase
SB48_RS06555	COG2086	electron transfer activity
SB48_RS06560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SB48_RS06570	COG3118	belongs to the thioredoxin family
SB48_RS06575	COG0322	excinuclease ABC activity
SB48_RS06585	COG1719	4-vinyl reductase, 4VR
SB48_RS06590	COG2009	succinate dehydrogenase
SB48_RS06595	COG1053	succinate dehydrogenase
SB48_RS06600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SB48_RS06605	COG0824	Thioesterase
SB48_RS06610	COG2197	response regulator
SB48_RS06640	COG1846	Transcriptional regulator
SB48_RS06655	COG5577	PFAM Coat F domain
SB48_RS06660	COG1063	alcohol dehydrogenase
SB48_RS06665	COG5577	PFAM Coat F domain
SB48_RS06675	COG5401	PFAM Sporulation and spore germination
SB48_RS06680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SB48_RS06685	COG0622	Phosphoesterase
SB48_RS06720	COG1477	protein flavinylation
SB48_RS06720	COG0457	Tetratricopeptide repeat
SB48_RS06725	COG0544	peptidyl-prolyl cis-trans isomerase activity
SB48_RS06735	COG0470	DNA polymerase III
SB48_RS06735	COG1067	ATP-dependent peptidase activity
SB48_RS06740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SB48_RS06745	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SB48_RS06760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SB48_RS06765	COG0181	hydroxymethylbilane synthase activity
SB48_RS06780	COG0113	porphobilinogen synthase activity
SB48_RS06785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SB48_RS06790	COG1388	LysM domain
SB48_RS06790	COG1388	LysM domain
SB48_RS06795	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SB48_RS06810	COG0285	dihydrofolate synthase activity
SB48_RS06845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SB48_RS06855	COG1459	type II secretion system
SB48_RS06880	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SB48_RS06890	COG2003	Belongs to the UPF0758 family
SB48_RS06895	COG1077	Cell shape determining protein MreB Mrl
SB48_RS06900	COG1792	Involved in formation and maintenance of cell shape
SB48_RS06910	COG0850	regulation of cytokinetic process
SB48_RS06915	COG2894	cell division
SB48_RS06925	COG1994	Peptidase M50
SB48_RS06930	COG1530	ribonuclease E activity
SB48_RS06935	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SB48_RS06940	COG2868	ribosomal protein
SB48_RS06945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SB48_RS06950	COG3290	protein histidine kinase activity
SB48_RS06955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SB48_RS06960	COG4492	Belongs to the UPF0735 family
SB48_RS06965	COG0077	Prephenate dehydratase
SB48_RS06970	COG1827	regulation of RNA biosynthetic process
SB48_RS06975	COG1388	LysM domain
SB48_RS06985	COG0217	transcriptional regulatory protein
SB48_RS06990	COG0632	four-way junction helicase activity
SB48_RS07005	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SB48_RS07010	COG0343	queuine tRNA-ribosyltransferase activity
SB48_RS07015	COG1862	Preprotein translocase
SB48_RS07025	COG2323	membrane
SB48_RS07030	COG2244	polysaccharide biosynthetic process
SB48_RS07040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SB48_RS07040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SB48_RS07050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SB48_RS07050	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SB48_RS07055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SB48_RS07060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SB48_RS07065	COG1490	D-aminoacyl-tRNA deacylase activity
SB48_RS07070	COG1846	Transcriptional regulator
SB48_RS07075	COG1566	PFAM secretion protein HlyD family protein
SB48_RS07080	COG2814	Major facilitator Superfamily
SB48_RS07085	COG4991	sh3 domain protein
SB48_RS07085	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB48_RS07085	COG3103	Sh3 type 3 domain protein
SB48_RS07090	COG0124	histidyl-tRNA synthetase
SB48_RS07095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SB48_RS07100	COG0385	Bile acid
SB48_RS07105	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SB48_RS07110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SB48_RS07115	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS07125	COG1959	2 iron, 2 sulfur cluster binding
SB48_RS07130	COG1104	cysteine desulfurase activity
SB48_RS07135	COG0482	sulfurtransferase activity
SB48_RS07145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SB48_RS07175	COG0628	permease
SB48_RS07180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SB48_RS07185	COG4472	Bacterial protein of unknown function (DUF965)
SB48_RS07190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SB48_RS07195	COG3906	Belongs to the UPF0473 family
SB48_RS07200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SB48_RS07205	COG4122	O-methyltransferase activity
SB48_RS07210	COG0572	uridine kinase
SB48_RS07215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SB48_RS07240	COG0450	alkyl hydroperoxide reductase
SB48_RS07245	COG3634	alkyl hydroperoxide reductase activity
SB48_RS07260	COG1183	phosphatidylcholine synthase activity
SB48_RS07305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB48_RS07315	COG0071	Belongs to the small heat shock protein (HSP20) family
SB48_RS07320	COG2132	Multicopper oxidase
SB48_RS07325	COG3835	regulator
SB48_RS07330	COG0277	FAD linked oxidase domain protein
SB48_RS07335	COG0247	lactate metabolic process
SB48_RS07340	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SB48_RS07345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SB48_RS07355	COG1534	Rna-binding protein
SB48_RS07360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SB48_RS07365	COG1713	HD superfamily hydrolase involved in NAD metabolism
SB48_RS07370	COG0799	negative regulation of ribosome biogenesis
SB48_RS07375	COG2226	methyltransferase
SB48_RS07380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SB48_RS07385	COG1596	polysaccharide export
SB48_RS07385	COG1555	photosystem II stabilization
SB48_RS07390	COG2131	deaminase
SB48_RS07395	COG0658	competence protein
SB48_RS07395	COG2333	competence protein COMEC
SB48_RS07405	COG1466	dna polymerase III delta subunit
SB48_RS07410	COG0268	Binds directly to 16S ribosomal RNA
SB48_RS07415	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SB48_RS07420	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB48_RS07425	COG0481	GTPase activity
SB48_RS07430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SB48_RS07440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SB48_RS07445	COG0443	Heat shock 70 kDa protein
SB48_RS07455	COG2264	protein methyltransferase activity
SB48_RS07460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SB48_RS07465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SB48_RS07470	COG1283	sodium-dependent phosphate transmembrane transporter activity
SB48_RS07485	COG1610	YqeY-like protein
SB48_RS07500	COG1702	phosphate starvation-inducible protein PhoH
SB48_RS07505	COG1480	7TM receptor with intracellular HD hydrolase
SB48_RS07510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SB48_RS07515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SB48_RS07525	COG1381	Involved in DNA repair and RecF pathway recombination
SB48_RS07530	COG0517	IMP dehydrogenase activity
SB48_RS07540	COG0358	DNA primase activity
SB48_RS07545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SB48_RS07555	COG2010	Cytochrome c
SB48_RS07560	COG2384	SAM-dependent methyltransferase
SB48_RS07565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SB48_RS07570	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SB48_RS07580	COG0513	Belongs to the DEAD box helicase family
SB48_RS07585	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SB48_RS07590	COG3883	PFAM NLP P60 protein
SB48_RS07590	COG0791	NLP P60 protein
SB48_RS07600	COG1121	(ABC) transporter
SB48_RS07605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SB48_RS07610	COG0735	belongs to the Fur family
SB48_RS07615	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
SB48_RS07620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SB48_RS07630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SB48_RS07635	COG0477	Major facilitator Superfamily
SB48_RS07640	COG0768	penicillin binding
SB48_RS07650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SB48_RS07655	COG0705	Rhomboid family
SB48_RS07655	COG0457	Tetratricopeptide repeat
SB48_RS07660	COG4483	Protein conserved in bacteria
SB48_RS07665	COG1940	carbohydrate kinase activity
SB48_RS07675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB48_RS07690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SB48_RS07695	COG1459	type II secretion system
SB48_RS07700	COG4537	Required for transformation and DNA binding
SB48_RS07725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SB48_RS07735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SB48_RS07740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SB48_RS07750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SB48_RS07755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SB48_RS07760	COG0095	Lipoate-protein ligase
SB48_RS07765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SB48_RS07785	COG1012	belongs to the aldehyde dehydrogenase family
SB48_RS07790	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB48_RS07795	COG0183	Belongs to the thiolase family
SB48_RS07800	COG3327	negative regulation of DNA-templated transcription, initiation
SB48_RS07810	COG1752	Esterase of the alpha-beta hydrolase superfamily
SB48_RS07820	COG3872	metal-dependent enzyme
SB48_RS07830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SB48_RS07835	COG0006	proline dipeptidase activity
SB48_RS07840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SB48_RS07845	COG3854	ATPases associated with a variety of cellular activities
SB48_RS07885	COG0511	ligase activity, forming carbon-carbon bonds
SB48_RS07890	COG0439	Biotin carboxylase
SB48_RS07895	COG1302	Protein conserved in bacteria
SB48_RS07910	COG1570	exodeoxyribonuclease VII activity
SB48_RS07925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SB48_RS07930	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SB48_RS07940	COG0497	DNA recombination
SB48_RS07945	COG0750	zinc metalloprotease
SB48_RS07955	COG0745	RESPONSE REGULATOR receiver
SB48_RS07960	COG0584	glycerophosphoryl diester phosphodiesterase
SB48_RS07985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SB48_RS07990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SB48_RS07995	COG0022	dehydrogenase e1 component
SB48_RS08000	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB48_RS08005	COG1105	Belongs to the carbohydrate kinase PfkB family
SB48_RS08015	COG1376	ErfK ybiS ycfS ynhG family protein
SB48_RS08025	COG2195	Cleaves the N-terminal amino acid of tripeptides
SB48_RS08035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SB48_RS08040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SB48_RS08050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SB48_RS08060	COG0300	oxidoreductase activity
SB48_RS08065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SB48_RS08075	COG1388	LysM domain
SB48_RS08075	COG3858	chitin binding
SB48_RS08080	COG1073	alpha beta
SB48_RS08085	COG3853	Toxic anion resistance protein (TelA)
SB48_RS08090	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
SB48_RS08105	COG0667	Aldo Keto reductase
SB48_RS08120	COG1379	DNA repair
SB48_RS08125	COG1300	Membrane
SB48_RS08130	COG0735	belongs to the Fur family
SB48_RS08140	COG4974	Belongs to the 'phage' integrase family
SB48_RS08145	COG1686	Belongs to the peptidase S11 family
SB48_RS08160	COG1191	sigma factor activity
SB48_RS08180	COG0697	spore germination
SB48_RS08200	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SB48_RS08205	COG1686	Belongs to the peptidase S11 family
SB48_RS08210	COG2715	membrane protein required for spore maturation
SB48_RS08215	COG0700	Nucleoside recognition
SB48_RS08220	COG1187	pseudouridine synthase activity
SB48_RS08225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB48_RS08230	COG1333	cytochrome c biogenesis protein
SB48_RS08235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SB48_RS08240	COG0745	RESPONSE REGULATOR receiver
SB48_RS08245	COG5002	protein histidine kinase activity
SB48_RS08250	COG0739	heme binding
SB48_RS08250	COG1196	nuclear chromosome segregation
SB48_RS08250	COG0741	lytic transglycosylase activity
SB48_RS08255	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SB48_RS08260	COG1141	Ferredoxin
SB48_RS08270	COG0514	ATP-dependent DNA helicase (RecQ)
SB48_RS08275	COG1266	CAAX protease self-immunity
SB48_RS08290	COG3546	catalase activity
SB48_RS08305	COG1408	metallophosphoesterase
SB48_RS08315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SB48_RS08320	COG0492	ferredoxin-NADP+ reductase activity
SB48_RS08325	COG2339	peptidase activity
SB48_RS08330	COG3409	Peptidoglycan-binding domain 1 protein
SB48_RS08330	COG3773	Cell wall hydrolase
SB48_RS08335	COG2959	enzyme of heme biosynthesis
SB48_RS08340	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SB48_RS08345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SB48_RS08350	COG0539	negative regulation of cytoplasmic translation
SB48_RS08360	COG1160	GTP binding
SB48_RS08380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SB48_RS08385	COG0776	regulation of translation
SB48_RS08395	COG0142	geranyltranstransferase activity
SB48_RS08400	COG2226	methyltransferase
SB48_RS08405	COG0142	geranyltranstransferase activity
SB48_RS08410	COG0105	UTP biosynthetic process
SB48_RS08415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SB48_RS08420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SB48_RS08425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SB48_RS08430	COG4401	Chorismate mutase type I
SB48_RS08435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SB48_RS08440	COG0287	Prephenate dehydrogenase
SB48_RS08445	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SB48_RS08450	COG0457	Tetratricopeptide repeat
SB48_RS08455	COG5582	Belongs to the UPF0302 family
SB48_RS08470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SB48_RS08480	COG4347	Protein of unknown function (DUF1405)
SB48_RS08490	COG2738	Putative neutral zinc metallopeptidase
SB48_RS08500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB48_RS08505	COG1694	Mazg nucleotide pyrophosphohydrolase
SB48_RS08510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SB48_RS08515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SB48_RS08520	COG0438	transferase activity, transferring glycosyl groups
SB48_RS08540	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SB48_RS08545	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SB48_RS08550	COG1199	ATP-dependent helicase activity
SB48_RS08550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SB48_RS08565	COG0017	Asparaginyl-tRNA synthetase
SB48_RS08580	COG3935	DnaD domain protein
SB48_RS08585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SB48_RS08590	COG4499	WXG100 protein secretion system (Wss), protein YukC
SB48_RS08590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SB48_RS08595	COG3331	DNA recombination
SB48_RS08620	COG0071	Belongs to the small heat shock protein (HSP20) family
SB48_RS08625	COG1111	helicase
SB48_RS08625	COG1205	dead DEAH box helicase
SB48_RS08630	COG3359	exonuclease
SB48_RS08640	COG4474	Belongs to the UPF0398 family
SB48_RS08650	COG0116	Belongs to the methyltransferase superfamily
SB48_RS08655	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SB48_RS08665	COG2233	PERMEase
SB48_RS08680	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SB48_RS08685	COG0789	Transcriptional regulator
SB48_RS08690	COG0174	glutamine synthetase
SB48_RS08695	COG0582	viral genome integration into host DNA
SB48_RS08710	COG0556	nucleotide-excision repair
SB48_RS08725	COG1396	sequence-specific DNA binding
SB48_RS08765	COG0629	single-stranded DNA binding
SB48_RS08805	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SB48_RS08810	COG0582	viral genome integration into host DNA
SB48_RS08845	COG0740	serine-type endopeptidase activity
SB48_RS08945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SB48_RS08955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SB48_RS08960	COG4224	UPF0291 protein
SB48_RS08975	COG3763	UPF0154 protein
SB48_RS08980	COG0785	Cytochrome C biogenesis protein
SB48_RS08985	COG2201	protein-glutamate methylesterase activity
SB48_RS08990	COG4846	Membrane protein involved in cytochrome C biogenesis
SB48_RS09000	COG0204	Acyl-transferase
SB48_RS09005	COG2027	D-alanyl-D-alanine carboxypeptidase
SB48_RS09010	COG1619	proteins homologs of microcin C7 resistance protein MccF
SB48_RS09030	COG3546	catalase activity
SB48_RS09045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SB48_RS09050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SB48_RS09055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SB48_RS09060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SB48_RS09065	COG0505	Belongs to the CarA family
SB48_RS09070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SB48_RS09075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SB48_RS09080	COG0137	argininosuccinate synthase activity
SB48_RS09085	COG0165	Argininosuccinate lyase
SB48_RS09090	COG0436	Aminotransferase
SB48_RS09115	COG0789	Transcriptional regulator
SB48_RS09120	COG4990	cell redox homeostasis
SB48_RS09130	COG2404	hydrolase activity, acting on ester bonds
SB48_RS09135	COG1252	NADH dehydrogenase
SB48_RS09145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SB48_RS09150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SB48_RS09155	COG0701	Predicted permease
SB48_RS09170	COG0709	Synthesizes selenophosphate from selenide and ATP
SB48_RS09175	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SB48_RS09190	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS09195	COG2030	dehydratase
SB48_RS09205	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SB48_RS09230	COG1131	(ABC) transporter
SB48_RS09235	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SB48_RS09245	COG0783	Belongs to the Dps family
SB48_RS09250	COG1914	H( )-stimulated, divalent metal cation uptake system
SB48_RS09255	COG0494	nUDIX hydrolase
SB48_RS09260	COG1247	-acetyltransferase
SB48_RS09280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SB48_RS09285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SB48_RS09290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SB48_RS09295	COG0297	glycogen (starch) synthase activity
SB48_RS09305	COG0708	Exodeoxyribonuclease III
SB48_RS09310	COG3773	Cell wall hydrolase
SB48_RS09315	COG2223	nitrite transmembrane transporter activity
SB48_RS09320	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS09325	COG0039	L-malate dehydrogenase activity
SB48_RS09340	COG2322	membrane
SB48_RS09345	COG0561	phosphatase activity
SB48_RS09355	COG2072	flavoprotein involved in K transport
SB48_RS09365	COG2233	PERMEase
SB48_RS09370	COG2508	Transcriptional regulator
SB48_RS09375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB48_RS09380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SB48_RS09400	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_RS09405	COG0183	Belongs to the thiolase family
SB48_RS09420	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SB48_RS09430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SB48_RS09445	COG3264	Mechanosensitive ion channel
SB48_RS09445	COG1511	domain protein
SB48_RS09450	COG3284	Transcriptional regulator
SB48_RS09455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SB48_RS09460	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB48_RS09465	COG0022	dehydrogenase e1 component
SB48_RS09470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SB48_RS09475	COG0697	spore germination
SB48_RS09480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB48_RS09485	COG0789	Transcriptional regulator
SB48_RS09495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SB48_RS09500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SB48_RS09505	COG2045	Belongs to the ComB family
SB48_RS09510	COG1809	phosphosulfolactate synthase activity
SB48_RS09520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB48_RS09525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB48_RS09530	COG2814	Major facilitator Superfamily
SB48_RS09535	COG1309	transcriptional regulator
SB48_RS09580	COG2258	MOSC domain
SB48_RS09585	COG0352	thiamine-phosphate diphosphorylase activity
SB48_RS09590	COG0351	phosphomethylpyrimidine kinase
SB48_RS09595	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SB48_RS09600	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS09605	COG0456	acetyltransferase
SB48_RS09610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SB48_RS09615	COG0456	acetyltransferase
SB48_RS09640	COG2226	methyltransferase
SB48_RS09660	COG0681	Belongs to the peptidase S26 family
SB48_RS09670	COG2070	2-Nitropropane dioxygenase
SB48_RS09695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SB48_RS09695	COG0574	Belongs to the PEP-utilizing enzyme family
SB48_RS09700	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SB48_RS09715	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SB48_RS09720	COG0187	DNA topoisomerase II activity
SB48_RS09725	COG1832	CoA-binding protein
SB48_RS09735	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SB48_RS09740	COG4841	protein insertion into membrane
SB48_RS09750	COG0824	Thioesterase
SB48_RS09765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SB48_RS09775	COG2309	aminopeptidase activity
SB48_RS09795	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_RS09800	COG1346	cytolysis
SB48_RS09805	COG1380	Effector of murein hydrolase LrgA
SB48_RS09815	COG1132	(ABC) transporter
SB48_RS09820	COG1132	(ABC) transporter
SB48_RS09830	COG0477	Major facilitator Superfamily
SB48_RS09850	COG1113	amino acid transport
SB48_RS09855	COG5039	Polysaccharide pyruvyl transferase
SB48_RS09860	COG2814	Major facilitator Superfamily
SB48_RS09865	COG0640	Transcriptional regulator
SB48_RS09875	COG3328	transposase activity
SB48_RS09895	COG0745	RESPONSE REGULATOR receiver
SB48_RS09900	COG0642	Histidine kinase
SB48_RS09905	COG1136	(ABC) transporter
SB48_RS09910	COG0577	efflux transmembrane transporter activity
SB48_RS09925	COG3634	alkyl hydroperoxide reductase activity
SB48_RS09930	COG0302	gtp cyclohydrolase
SB48_RS09935	COG1278	Cold shock
SB48_RS09945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SB48_RS09955	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SB48_RS09960	COG2807	transmembrane transport
SB48_RS09980	COG0569	domain protein
SB48_RS09985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SB48_RS09990	COG2962	Rard protein
SB48_RS09995	COG2391	methyltransferase activity
SB48_RS10005	COG0140	phosphoribosyl-ATP diphosphatase activity
SB48_RS10005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SB48_RS10010	COG0107	imidazoleglycerol-phosphate synthase activity
SB48_RS10020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SB48_RS10025	COG0131	Imidazoleglycerol-phosphate dehydratase
SB48_RS10030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SB48_RS10035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SB48_RS10040	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SB48_RS10050	COG0598	Magnesium transport protein CorA
SB48_RS10055	COG1280	lysine exporter protein (LysE YggA)
SB48_RS10060	COG1113	amino acid transport
SB48_RS10065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SB48_RS10070	COG1388	LysM domain
SB48_RS10070	COG3584	3D domain protein
SB48_RS10075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SB48_RS10075	COG0723	plastoquinol--plastocyanin reductase activity
SB48_RS10080	COG0516	GMP reductase activity
SB48_RS10080	COG0517	IMP dehydrogenase activity
SB48_RS10085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB48_RS10095	COG2135	peptidase activity
SB48_RS10100	COG1054	Belongs to the UPF0176 family
SB48_RS10110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB48_RS10135	COG1012	belongs to the aldehyde dehydrogenase family
SB48_RS10140	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB48_RS10145	COG0567	Dehydrogenase, E1 component
SB48_RS10155	COG5002	protein histidine kinase activity
SB48_RS10160	COG0745	RESPONSE REGULATOR receiver
SB48_RS10170	COG2814	Major facilitator Superfamily
SB48_RS10175	COG1331	Highly conserved protein containing a thioredoxin domain
SB48_RS10180	COG1368	sulfuric ester hydrolase activity
SB48_RS10185	COG0671	phosphoesterase, PA-phosphatase related
SB48_RS10190	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SB48_RS10195	COG3285	dna ligase
SB48_RS10195	COG1793	dna ligase
SB48_RS10210	COG0534	Mate efflux family protein
SB48_RS10215	COG2340	Cysteine-rich secretory protein family
SB48_RS10225	COG1846	Transcriptional regulator
SB48_RS10230	COG3409	Peptidoglycan-binding domain 1 protein
SB48_RS10230	COG0793	Belongs to the peptidase S41A family
SB48_RS10235	COG1876	peptidase activity
SB48_RS10255	COG4479	Belongs to the UPF0346 family
SB48_RS10260	COG0840	transmembrane signaling receptor activity
SB48_RS10265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SB48_RS10270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SB48_RS10275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SB48_RS10275	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SB48_RS10285	COG2755	lipolytic protein G-D-S-L family
SB48_RS10290	COG1272	protein, Hemolysin III
SB48_RS10295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SB48_RS10300	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SB48_RS10320	COG1413	lyase activity
SB48_RS10325	COG0488	(ABC) transporter
SB48_RS10330	COG1418	mRNA catabolic process
SB48_RS10340	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SB48_RS10350	COG1321	iron dependent repressor
SB48_RS10370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SB48_RS10375	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SB48_RS10380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SB48_RS10385	COG0464	growth
SB48_RS10400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SB48_RS10430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SB48_RS10435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SB48_RS10445	COG4550	Control of competence regulator ComK, YlbF/YmcA
SB48_RS10450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SB48_RS10460	COG1012	belongs to the aldehyde dehydrogenase family
SB48_RS10465	COG3829	transcription factor binding
SB48_RS10470	COG0531	amino acid
SB48_RS10475	COG0826	peptidase U32
SB48_RS10480	COG0826	peptidase U32
SB48_RS10485	COG2359	stage V sporulation protein S
SB48_RS10490	COG1692	metallophosphoesterase
SB48_RS10495	COG1418	mRNA catabolic process
SB48_RS10510	COG1058	Belongs to the CinA family
SB48_RS10510	COG1546	Belongs to the CinA family
SB48_RS10515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SB48_RS10520	COG1426	Protein conserved in bacteria
SB48_RS10535	COG0300	oxidoreductase activity
SB48_RS10540	COG0612	Peptidase, M16
SB48_RS10545	COG0612	Peptidase, M16
SB48_RS10550	COG1079	Belongs to the binding-protein-dependent transport system permease family
SB48_RS10555	COG4603	Belongs to the binding-protein-dependent transport system permease family
SB48_RS10560	COG3845	ABC transporter
SB48_RS10565	COG1744	ABC transporter substrate-binding protein PnrA-like
SB48_RS10570	COG1674	ftsk spoiiie
SB48_RS10570	COG4980	gas vesicle protein
SB48_RS10580	COG0740	serine-type endopeptidase activity
SB48_RS10585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SB48_RS10600	COG0527	aspartate kinase activity
SB48_RS10610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SB48_RS10615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SB48_RS10620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SB48_RS10625	COG1873	PFAM PRC-barrel domain
SB48_RS10630	COG0612	Peptidase, M16
SB48_RS10635	COG0726	polysaccharide deacetylase
SB48_RS10640	COG1185	polyribonucleotide nucleotidyltransferase activity
SB48_RS10645	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SB48_RS10650	COG0196	riboflavin kinase activity
SB48_RS10655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SB48_RS10660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SB48_RS10665	COG1550	Protein conserved in bacteria
SB48_RS10675	COG1358	cellular component organization or biogenesis
SB48_RS10680	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SB48_RS10685	COG0195	Participates in both transcription termination and antitermination
SB48_RS10690	COG0779	Required for maturation of 30S ribosomal subunits
SB48_RS10695	COG2176	DNA-directed DNA polymerase activity
SB48_RS10700	COG0442	prolyl-tRNA aminoacylation
SB48_RS10705	COG0750	zinc metalloprotease
SB48_RS10715	COG4589	Belongs to the CDS family
SB48_RS10720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SB48_RS10730	COG0233	cytoplasmic translational termination
SB48_RS10735	COG0528	UMP kinase activity
SB48_RS10740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SB48_RS10745	COG0052	Belongs to the universal ribosomal protein uS2 family
SB48_RS10755	COG1191	sigma factor activity
SB48_RS10760	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SB48_RS10765	COG1776	CheC inhibitor of MCP methylation
SB48_RS10770	COG0835	chemotaxis
SB48_RS10775	COG2198	Histidine kinase
SB48_RS10775	COG0643	Histidine kinase
SB48_RS10780	COG2201	protein-glutamate methylesterase activity
SB48_RS10785	COG0455	bacterial-type flagellum organization
SB48_RS10790	COG1419	protein localization to endoplasmic reticulum
SB48_RS10795	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SB48_RS10800	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SB48_RS10805	COG1684	flagellar biosynthetic protein fliR
SB48_RS10810	COG1987	bacterial-type flagellum assembly
SB48_RS10815	COG1338	Plays a role in the flagellum-specific transport system
SB48_RS10820	COG3190	flagellar
SB48_RS10825	COG2201	protein-glutamate methylesterase activity
SB48_RS10830	COG1776	CheC inhibitor of MCP methylation
SB48_RS10830	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SB48_RS10835	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SB48_RS10840	COG1580	Controls the rotational direction of flagella during chemotaxis
SB48_RS10850	COG4786	Flagellar basal body rod
SB48_RS10860	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SB48_RS10875	COG2882	bacterial-type flagellum organization
SB48_RS10880	COG1157	protein secretion by the type III secretion system
SB48_RS10885	COG1317	bacterial-type flagellum organization
SB48_RS10895	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SB48_RS10900	COG1766	The M ring may be actively involved in energy transduction
SB48_RS10905	COG1677	Flagellar hook-basal body complex protein FliE
SB48_RS10910	COG1558	bacterial-type flagellum-dependent cell motility
SB48_RS10915	COG1815	bacterial-type flagellum-dependent cell motility
SB48_RS10925	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SB48_RS10935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SB48_RS10940	COG4974	Belongs to the 'phage' integrase family
SB48_RS10955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SB48_RS10960	COG0758	DNA mediated transformation
SB48_RS10965	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SB48_RS10970	COG0045	succinate-CoA ligase (ADP-forming) activity
SB48_RS10975	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SB48_RS10990	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SB48_RS11005	COG0336	Belongs to the RNA methyltransferase TrmD family
SB48_RS11010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SB48_RS11020	COG1837	Belongs to the UPF0109 family
SB48_RS11030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SB48_RS11035	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SB48_RS11040	COG0552	protein localization to endoplasmic reticulum
SB48_RS11050	COG1196	nuclear chromosome segregation
SB48_RS11055	COG0571	ribonuclease III activity
SB48_RS11065	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS11070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SB48_RS11075	COG0416	fatty acid biosynthetic process
SB48_RS11080	COG1349	DNA-binding transcription factor activity
SB48_RS11085	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SB48_RS11090	COG1760	l-serine dehydratase
SB48_RS11095	COG1760	l-serine dehydratase
SB48_RS11105	COG1461	Dihydroxyacetone kinase
SB48_RS11110	COG1302	Protein conserved in bacteria
SB48_RS11115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SB48_RS11125	COG1564	THIamine pyrophosphokinase
SB48_RS11130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SB48_RS11140	COG0515	serine threonine protein kinase
SB48_RS11140	COG2815	serine threonine protein kinase
SB48_RS11145	COG0631	protein serine/threonine phosphatase activity
SB48_RS11150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SB48_RS11150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SB48_RS11155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SB48_RS11160	COG0242	peptide deformylase activity
SB48_RS11165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SB48_RS11170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SB48_RS11175	COG1758	RNA polymerase activity
SB48_RS11180	COG0194	GDP metabolic process
SB48_RS11185	COG2052	Domain of unknown function (DUF370)
SB48_RS11190	COG1561	YicC-like family, N-terminal region
SB48_RS11195	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SB48_RS11205	COG0385	Bile acid
SB48_RS11215	COG0720	synthase
SB48_RS11250	COG0561	phosphatase activity
SB48_RS11255	COG0628	permease
SB48_RS11265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB48_RS11270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_RS11280	COG2076	Multidrug Resistance protein
SB48_RS11290	COG1309	transcriptional regulator
SB48_RS11295	COG0477	Major facilitator Superfamily
SB48_RS11300	COG0477	Major facilitator Superfamily
SB48_RS11305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SB48_RS11320	COG1803	Methylglyoxal synthase
SB48_RS11325	COG0235	Class ii aldolase
SB48_RS11330	COG4806	L-rhamnose isomerase
SB48_RS11335	COG1070	Carbohydrate kinase
SB48_RS11340	COG1917	Cupin 2, conserved barrel domain protein
SB48_RS11340	COG2207	Transcriptional regulator
SB48_RS11365	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SB48_RS11370	COG0284	orotidine-5'-phosphate decarboxylase activity
SB48_RS11375	COG0167	dihydroorotate dehydrogenase activity
SB48_RS11395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SB48_RS11400	COG0540	Belongs to the ATCase OTCase family
SB48_RS11420	COG0564	pseudouridine synthase activity
SB48_RS11425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SB48_RS11445	COG3599	regulation of cell shape
SB48_RS11450	COG2302	S4 RNA-binding domain
SB48_RS11455	COG0762	integral membrane protein
SB48_RS11460	COG1799	cell septum assembly
SB48_RS11465	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SB48_RS11475	COG1388	LysM domain
SB48_RS11475	COG3584	3D domain protein
SB48_RS11480	COG1873	PFAM PRC-barrel domain
SB48_RS11485	COG1191	sigma factor activity
SB48_RS11490	COG1191	sigma factor activity
SB48_RS11505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SB48_RS11510	COG0849	cell division
SB48_RS11515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SB48_RS11520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SB48_RS11525	COG0772	Belongs to the SEDS family
SB48_RS11530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SB48_RS11535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SB48_RS11550	COG0768	penicillin binding
SB48_RS11555	COG0768	penicillin binding
SB48_RS11560	COG4839	cell division protein FtsL
SB48_RS11565	COG0275	rRNA processing
SB48_RS11570	COG2001	Belongs to the MraZ family
SB48_RS11575	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SB48_RS11580	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SB48_RS11585	COG0454	-acetyltransferase
SB48_RS11595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SB48_RS11600	COG1399	metal-binding, possibly nucleic acid-binding protein
SB48_RS11605	COG1323	Belongs to the UPF0348 family
SB48_RS11615	COG3480	Lon protease (S16) C-terminal proteolytic domain
SB48_RS11620	COG1752	Esterase of the alpha-beta hydrolase superfamily
SB48_RS11625	COG3314	Sporulation integral membrane protein YlbJ
SB48_RS11630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SB48_RS11635	COG0742	ribosomal rna small subunit methyltransferase
SB48_RS11650	COG4471	UPF0298 protein
SB48_RS11655	COG3679	Belongs to the UPF0342 family
SB48_RS11675	COG2050	protein possibly involved in aromatic compounds catabolism
SB48_RS11680	COG2340	Cysteine-rich secretory protein family
SB48_RS11690	COG3336	cytochrome c oxidase
SB48_RS11695	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SB48_RS11710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SB48_RS11710	COG2010	Cytochrome c
SB48_RS11715	COG0109	protoheme IX farnesyltransferase activity
SB48_RS11720	COG1612	heme a metabolic process
SB48_RS11725	COG0772	Belongs to the SEDS family
SB48_RS11730	COG4838	Belongs to the UPF0358 family
SB48_RS11735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SB48_RS11740	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SB48_RS11750	COG1217	gtp-binding protein TYPA
SB48_RS11760	COG0483	inositol monophosphate 1-phosphatase activity
SB48_RS11775	COG4476	Belongs to the UPF0223 family
SB48_RS11780	COG1982	Orn Lys Arg decarboxylase major
SB48_RS11820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SB48_RS11830	COG1473	amidohydrolase
SB48_RS11835	COG2171	N-acyltransferase activity
SB48_RS11840	COG0583	DNA-binding transcription factor activity
SB48_RS11845	COG0517	IMP dehydrogenase activity
SB48_RS11850	COG4703	Protein of unknown function (DUF1797)
SB48_RS11860	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS11880	COG2409	Drug exporters of the RND superfamily
SB48_RS11880	COG1033	growth of symbiont in host cell
SB48_RS11890	COG0784	Response regulator, receiver
SB48_RS11890	COG0835	chemotaxis
SB48_RS11895	COG0436	Aminotransferase
SB48_RS11900	COG2084	Dehydrogenase
SB48_RS11920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_RS11935	COG4873	Protein conserved in bacteria
SB48_RS11945	COG3949	Membrane
SB48_RS11950	COG0542	response to heat
SB48_RS11965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SB48_RS11995	COG0861	Integral membrane protein TerC family
SB48_RS12015	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SB48_RS12020	COG3852	Histidine kinase
SB48_RS12025	COG0673	inositol 2-dehydrogenase activity
SB48_RS12030	COG0783	Belongs to the Dps family
SB48_RS12035	COG0730	response to heat
SB48_RS12045	COG1959	2 iron, 2 sulfur cluster binding
SB48_RS12065	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS12110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SB48_RS12115	COG1554	hydrolase, family 65, central catalytic
SB48_RS12125	COG1609	Transcriptional regulator
SB48_RS12140	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SB48_RS12145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SB48_RS12165	COG1522	sequence-specific DNA binding
SB48_RS12170	COG2059	Chromate
SB48_RS12175	COG2059	Chromate
SB48_RS12180	COG3344	reverse transcriptase
SB48_RS12190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SB48_RS12240	COG3579	cysteine-type endopeptidase activity
SB48_RS12250	COG1668	transmembrane transport
SB48_RS12255	COG4152	abc transporter atp-binding protein
SB48_RS12260	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS12270	COG1940	carbohydrate kinase activity
SB48_RS12295	COG2382	esterase
SB48_RS12305	COG2153	protein acetylation
SB48_RS12340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SB48_RS12380	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SB48_RS12385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SB48_RS12390	COG0564	pseudouridine synthase activity
SB48_RS12400	COG2357	RelA SpoT domain protein
SB48_RS12415	COG0741	lytic transglycosylase activity
SB48_RS12435	COG2346	COG2346, Truncated hemoglobins
SB48_RS12440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SB48_RS12450	COG1164	Oligoendopeptidase f
SB48_RS12455	COG4469	Competence protein
SB48_RS12460	COG4862	establishment of competence for transformation
SB48_RS12470	COG1393	Belongs to the ArsC family
SB48_RS12475	COG4608	Belongs to the ABC transporter superfamily
SB48_RS12480	COG0444	Belongs to the ABC transporter superfamily
SB48_RS12485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SB48_RS12490	COG0601	transmembrane transport
SB48_RS12495	COG4166	transmembrane transport
SB48_RS12510	COG0180	Tryptophanyl-tRNA synthetase
SB48_RS12520	COG0747	negative chemotaxis
SB48_RS12530	COG0601	transmembrane transport
SB48_RS12535	COG4608	Belongs to the ABC transporter superfamily
SB48_RS12555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SB48_RS12560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SB48_RS12590	COG2151	metal-sulfur cluster biosynthetic enzyme
SB48_RS12595	COG0561	phosphatase activity
SB48_RS12610	COG1307	EDD domain protein, DegV family
SB48_RS12615	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS12630	COG0179	Fumarylacetoacetate (FAA) hydrolase
SB48_RS12635	COG2311	Membrane
SB48_RS12670	COG1074	ATP-dependent DNA helicase activity
SB48_RS12675	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SB48_RS12700	COG0501	Belongs to the peptidase M48B family
SB48_RS12710	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SB48_RS12715	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_RS12720	COG0095	Lipoate-protein ligase
SB48_RS12730	COG1999	signal sequence binding
SB48_RS12735	COG1012	belongs to the aldehyde dehydrogenase family
SB48_RS12740	COG0697	spore germination
SB48_RS12745	COG2814	Major facilitator Superfamily
SB48_RS12750	COG3254	rhamnose metabolic process
SB48_RS12755	COG1349	DNA-binding transcription factor activity
SB48_RS12760	COG1263	PTS System
SB48_RS12760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_RS12760	COG1263	PTS System
SB48_RS12760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_RS12760	COG2190	(PTS) system
SB48_RS12760	COG2190	(PTS) system
SB48_RS12765	COG1511	domain protein
SB48_RS12770	COG1309	transcriptional regulator
SB48_RS12775	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SB48_RS12780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SB48_RS12785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SB48_RS12790	COG2329	Antibiotic biosynthesis monooxygenase
SB48_RS12795	COG3069	C4-dicarboxylate transmembrane transporter activity
SB48_RS12800	COG1473	amidohydrolase
SB48_RS12805	COG4473	ABC transporter
SB48_RS12810	COG1131	(ABC) transporter
SB48_RS12815	COG0537	adenosine 5'-monophosphoramidase activity
SB48_RS12835	COG1846	Transcriptional regulator
SB48_RS12850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SB48_RS12860	COG3481	metal-dependent phosphohydrolase, HD sub domain
SB48_RS12865	COG4717	serine-type aminopeptidase activity
SB48_RS12870	COG0420	3'-5' exonuclease activity
SB48_RS12875	COG3689	TIGRFAM TIGR03943 family protein
SB48_RS12880	COG0701	Predicted permease
SB48_RS12885	COG0861	Integral membrane protein TerC family
SB48_RS12895	COG1024	Enoyl-CoA hydratase
SB48_RS12900	COG0561	phosphatase activity
SB48_RS12910	COG4399	Belongs to the UPF0754 family
SB48_RS12925	COG0189	ligase activity
SB48_RS12930	COG0189	ligase activity
SB48_RS12940	COG2508	Transcriptional regulator
SB48_RS12945	COG3842	ATPase activity
SB48_RS12980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_RS12985	COG1481	regulation of sporulation
SB48_RS12990	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SB48_RS12995	COG1660	Displays ATPase and GTPase activities
SB48_RS13000	COG1051	belongs to the nudix hydrolase family
SB48_RS13010	COG0492	ferredoxin-NADP+ reductase activity
SB48_RS13015	COG0457	Tetratricopeptide repeat
SB48_RS13020	COG0110	maltose O-acetyltransferase activity
SB48_RS13025	COG0546	phosphoglycolate phosphatase activity
SB48_RS13030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SB48_RS13035	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SB48_RS13045	COG3595	metallopeptidase activity
SB48_RS13050	COG0463	Glycosyl transferase, family 2
SB48_RS13050	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SB48_RS13055	COG1682	transport, permease protein
SB48_RS13060	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SB48_RS13070	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SB48_RS13075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SB48_RS13080	COG0556	nucleotide-excision repair
SB48_RS13130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SB48_RS13135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SB48_RS13145	COG0581	inorganic phosphate transmembrane transporter activity
SB48_RS13150	COG0573	inorganic phosphate transmembrane transporter activity
SB48_RS13160	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SB48_RS13165	COG5002	protein histidine kinase activity
SB48_RS13170	COG0745	RESPONSE REGULATOR receiver
SB48_RS13185	COG4607	ABC-type enterochelin transport system periplasmic component
SB48_RS13190	COG4604	ABC transporter, ATP-binding protein
SB48_RS13195	COG4605	iron ion homeostasis
SB48_RS13200	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB48_RS13205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SB48_RS13220	COG3409	Peptidoglycan-binding domain 1 protein
SB48_RS13220	COG0793	Belongs to the peptidase S41A family
SB48_RS13225	COG0460	homoserine dehydrogenase
SB48_RS13245	COG0739	heme binding
SB48_RS13250	COG2177	Part of the ABC transporter FtsEX involved in
SB48_RS13255	COG2884	Cell division ATP-binding protein ftsE
SB48_RS13265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB48_RS13280	COG0653	protein targeting
SB48_RS13305	COG1516	flagellar protein fliS
SB48_RS13310	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SB48_RS13315	COG1334	flagellar protein FlaG
SB48_RS13330	COG2094	Belongs to the DNA glycosylase MPG family
SB48_RS13350	COG1067	ATP-dependent peptidase activity
SB48_RS13365	COG1113	amino acid transport
SB48_RS13375	COG1113	amino acid transport
SB48_RS13380	COG2271	Major facilitator Superfamily
SB48_RS13390	COG0647	UMP catabolic process
SB48_RS13395	COG1285	pathogenesis
SB48_RS13400	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SB48_RS13420	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SB48_RS13430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SB48_RS13435	COG1256	bacterial-type flagellum assembly
SB48_RS13435	COG4786	Flagellar basal body rod
SB48_RS13445	COG2747	anti-sigma28 factor FlgM
SB48_RS13455	COG1040	competence protein
SB48_RS13460	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SB48_RS13465	COG1307	EDD domain protein, DegV family
SB48_RS13470	COG0531	amino acid
SB48_RS13480	COG2197	response regulator
SB48_RS13490	COG1739	Uncharacterized protein family UPF0029
SB48_RS13500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SB48_RS13510	COG0768	penicillin binding
SB48_RS13520	COG0791	NLP P60 protein
SB48_RS13520	COG1388	LysM domain
SB48_RS13525	COG2188	Transcriptional regulator
SB48_RS13535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SB48_RS13540	COG0477	Major facilitator Superfamily
SB48_RS13550	COG1482	cell wall glycoprotein biosynthetic process
SB48_RS13555	COG0346	lactoylglutathione lyase activity
SB48_RS13560	COG2996	Protein conserved in bacteria
SB48_RS13575	COG1609	Transcriptional regulator
SB48_RS13590	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SB48_RS13595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SB48_RS13620	COG1960	acyl-CoA dehydrogenase activity
SB48_RS13635	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SB48_RS13640	COG2409	Drug exporters of the RND superfamily
SB48_RS13640	COG1033	growth of symbiont in host cell
SB48_RS13650	COG2814	Major facilitator Superfamily
SB48_RS13655	COG1113	amino acid transport
SB48_RS13660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SB48_RS13710	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SB48_RS13725	COG2226	methyltransferase
SB48_RS13735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB48_RS13745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SB48_RS13755	COG0436	Aminotransferase
SB48_RS13760	COG0789	Transcriptional regulator
SB48_RS13785	COG0534	Mate efflux family protein
SB48_RS13790	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB48_RS13795	COG4717	serine-type aminopeptidase activity
SB48_RS13800	COG0420	3'-5' exonuclease activity
SB48_RS13805	COG0431	NADPH-dependent FMN reductase
SB48_RS13810	COG0656	L-ascorbic acid biosynthetic process
SB48_RS13815	COG0657	acetylesterase activity
SB48_RS13825	COG0656	L-ascorbic acid biosynthetic process
SB48_RS13845	COG0561	phosphatase activity
SB48_RS13855	COG1609	Transcriptional regulator
SB48_RS13865	COG1063	alcohol dehydrogenase
SB48_RS13870	COG0457	Tetratricopeptide repeat
SB48_RS13880	COG0535	radical SAM domain protein
SB48_RS13895	COG0589	response to stress
SB48_RS13900	COG2244	polysaccharide biosynthetic process
SB48_RS13905	COG2746	aminoglycoside 3-N-acetyltransferase activity
SB48_RS13910	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS13915	COG1960	acyl-CoA dehydrogenase activity
SB48_RS13920	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_RS13930	COG1268	BioY protein
SB48_RS13935	COG0024	Methionine aminopeptidase
SB48_RS13940	COG0791	NLP P60 protein
SB48_RS13940	COG1388	LysM domain
SB48_RS13960	COG1454	alcohol dehydrogenase
SB48_RS13960	COG1012	belongs to the aldehyde dehydrogenase family
SB48_RS13985	COG4145	pantothenate transmembrane transporter activity
SB48_RS13995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SB48_RS14000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SB48_RS14010	COG0010	Belongs to the arginase family
SB48_RS14015	COG0460	homoserine dehydrogenase
SB48_RS14020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SB48_RS14025	COG0083	homoserine kinase activity
SB48_RS14030	COG1116	anion transmembrane transporter activity
SB48_RS14035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB48_RS14040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB48_RS14050	COG0154	amidase activity
SB48_RS14060	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SB48_RS14065	COG2079	MmgE PrpD family protein
SB48_RS14080	COG3716	PTS system mannose fructose sorbose family IID component
SB48_RS14085	COG3715	PTS system
SB48_RS14095	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_RS14095	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_RS14100	COG3933	PFAM sigma-54 factor interaction domain-containing protein
SB48_RS14100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SB48_RS14110	COG2706	6-phosphogluconolactonase activity
SB48_RS14115	COG0011	TIGRFAM Protein of
SB48_RS14125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SB48_RS14135	COG1388	LysM domain
SB48_RS14135	COG3584	3D domain protein
SB48_RS14150	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SB48_RS14165	COG0577	efflux transmembrane transporter activity
SB48_RS14165	COG1136	(ABC) transporter
SB48_RS14170	COG1316	TRANSCRIPTIONal
SB48_RS14175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SB48_RS14185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SB48_RS14195	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SB48_RS14200	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS14225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SB48_RS14230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SB48_RS14235	COG0604	alcohol dehydrogenase
SB48_RS14250	COG2207	Transcriptional regulator
SB48_RS14255	COG1653	transport
SB48_RS14275	COG0626	cystathionine gamma-synthase activity
SB48_RS14280	COG0626	cystathionine gamma-synthase activity
SB48_RS14290	COG1131	(ABC) transporter
SB48_RS14300	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SB48_RS14305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_RS14305	COG3711	transcriptional antiterminator
SB48_RS14310	COG2723	6-phospho-beta-galactosidase activity
SB48_RS14315	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB48_RS14315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB48_RS14330	COG1447	Phosphotransferase system cellobiose-specific component IIA
SB48_RS14395	COG2186	Transcriptional regulator
SB48_RS14400	COG1620	l-lactate permease
SB48_RS14410	COG0531	amino acid
SB48_RS14430	COG2972	Histidine kinase
SB48_RS14475	COG1363	Peptidase, m42
SB48_RS14490	COG1309	transcriptional regulator
SB48_RS14515	COG1501	Belongs to the glycosyl hydrolase 31 family
SB48_RS14520	COG3290	protein histidine kinase activity
SB48_RS14520	COG3829	transcription factor binding
SB48_RS14530	COG1012	belongs to the aldehyde dehydrogenase family
SB48_RS14535	COG2610	gluconate transmembrane transporter activity
SB48_RS14540	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS14570	COG2116	formate transmembrane transporter activity
SB48_RS14580	COG1104	cysteine desulfurase activity
SB48_RS14585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SB48_RS14590	COG0157	Belongs to the NadC ModD family
SB48_RS14605	COG2115	Belongs to the xylose isomerase family
SB48_RS14610	COG1070	Carbohydrate kinase
SB48_RS14615	COG2814	Major facilitator Superfamily
SB48_RS14620	COG0371	Dehydrogenase
SB48_RS14630	COG0606	chelatase, subunit chli
SB48_RS14635	COG2272	Belongs to the type-B carboxylesterase lipase family
SB48_RS14645	COG3425	synthase
SB48_RS14660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB48_RS14670	COG4297	protein containing double-stranded beta helix domain
SB48_RS14685	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS14690	COG0110	maltose O-acetyltransferase activity
SB48_RS14695	COG1510	regulation of RNA biosynthetic process
SB48_RS14700	COG1125	glycine betaine transport
SB48_RS14700	COG0517	IMP dehydrogenase activity
SB48_RS14705	COG1174	glycine betaine transport
SB48_RS14710	COG1732	Glycine betaine
SB48_RS14715	COG1174	glycine betaine transport
SB48_RS14725	COG1609	Transcriptional regulator
SB48_RS14730	COG2814	Major facilitator Superfamily
SB48_RS14740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB48_RS14760	COG1113	amino acid transport
SB48_RS14765	COG2190	(PTS) system
SB48_RS14765	COG2211	Major facilitator Superfamily
SB48_RS14770	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB48_RS14780	COG1447	Phosphotransferase system cellobiose-specific component IIA
SB48_RS14785	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB48_RS14790	COG3711	transcriptional antiterminator
SB48_RS14790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_RS14805	COG2130	NADP-dependent
SB48_RS14810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SB48_RS14840	COG4989	oxidoreductase activity
SB48_RS14850	COG1316	TRANSCRIPTIONal
SB48_RS14855	COG0531	amino acid
SB48_RS14880	COG2333	competence protein COMEC
SB48_RS14880	COG0658	competence protein
SB48_RS14890	COG2315	Protein conserved in bacteria
SB48_RS14900	COG0145	ligase activity
SB48_RS14910	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SB48_RS14930	COG0235	Class ii aldolase
SB48_RS14935	COG1105	Belongs to the carbohydrate kinase PfkB family
SB48_RS14945	COG3775	system Galactitol-specific IIC component
SB48_RS14950	COG3414	Phosphotransferase system galactitol-specific IIB component
SB48_RS14970	COG3716	PTS system mannose fructose sorbose family IID component
SB48_RS14975	COG3715	PTS system
SB48_RS14980	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_RS14980	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_RS14990	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SB48_RS14990	COG3933	PFAM sigma-54 factor interaction domain-containing protein
SB48_RS14995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SB48_RS15000	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
SB48_RS15010	COG1396	sequence-specific DNA binding
SB48_RS15015	COG2188	Transcriptional regulator
SB48_RS15020	COG0363	glucosamine-6-phosphate deaminase activity
SB48_RS15025	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_RS15030	COG3715	PTS system
SB48_RS15035	COG3716	PTS system mannose fructose sorbose family IID component
SB48_RS15080	COG2226	methyltransferase
SB48_RS15085	COG5504	Zn-dependent protease
SB48_RS15100	COG4193	domain, Protein
SB48_RS15130	COG1063	alcohol dehydrogenase
SB48_RS15135	COG1940	carbohydrate kinase activity
SB48_RS15145	COG1070	Carbohydrate kinase
SB48_RS15175	COG1070	Carbohydrate kinase
SB48_RS15180	COG2115	Belongs to the xylose isomerase family
SB48_RS15190	COG1501	Belongs to the glycosyl hydrolase 31 family
SB48_RS15215	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SB48_RS15220	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SB48_RS15220	COG0662	Cupin 2, conserved barrel domain protein
SB48_RS15255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SB48_RS15260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SB48_RS15265	COG4464	protein tyrosine phosphatase activity
SB48_RS15270	COG0489	protein tyrosine kinase activity
SB48_RS15275	COG3944	biosynthesis protein
SB48_RS15305	COG0646	methionine synthase
SB48_RS15305	COG1410	methionine synthase
SB48_RS15310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SB48_RS15310	COG0646	methionine synthase
SB48_RS15330	COG0586	Pfam SNARE associated Golgi protein
SB48_RS15335	COG0586	Pfam SNARE associated Golgi protein
SB48_RS15350	COG1733	regulation of RNA biosynthetic process
SB48_RS15365	COG0765	amino acid transport
SB48_RS15370	COG0765	amino acid transport
SB48_RS15375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_RS15390	COG0628	permease
SB48_RS15400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SB48_RS15410	COG0531	amino acid
SB48_RS15415	COG0423	glycine-tRNA ligase activity
SB48_RS15435	COG1902	pentaerythritol trinitrate reductase activity
SB48_RS15470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SB48_RS15475	COG1301	dicarboxylic acid transport
SB48_RS15480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SB48_RS15485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SB48_RS15490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SB48_RS15495	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SB48_RS15510	COG3973	AAA domain
SB48_RS15515	COG0463	Glycosyl transferase, family 2
SB48_RS15520	COG2851	Citrate transporter
SB48_RS15525	COG4565	transcriptional regulatory protein
SB48_RS15530	COG3290	protein histidine kinase activity
SB48_RS15535	COG0004	ammonium transporteR
SB48_RS15540	COG1979	alcohol dehydrogenase
SB48_RS15545	COG0531	amino acid
SB48_RS15570	COG1953	Uracil, thiamine, allantoin
SB48_RS15580	COG1454	alcohol dehydrogenase
SB48_RS15585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SB48_RS15595	COG0247	lactate metabolic process
SB48_RS15600	COG1139	Iron-sulfur cluster binding protein
SB48_RS15605	COG1556	Lactate utilization protein
SB48_RS15610	COG0531	amino acid
SB48_RS15665	COG1176	ABC-type spermidine putrescine transport system, permease component I
SB48_RS15670	COG3842	ATPase activity
SB48_RS15680	COG0833	amino acid
SB48_RS15685	COG3104	oligopeptide transport
SB48_RS15695	COG1113	amino acid transport
SB48_RS15705	COG0667	Aldo Keto reductase
SB48_RS15710	COG5577	PFAM Coat F domain
SB48_RS15720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SB48_RS15735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SB48_RS15745	COG1609	Transcriptional regulator
SB48_RS15750	COG2848	UPF0210 protein
SB48_RS15770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SB48_RS15775	COG0246	Mannitol dehydrogenase
SB48_RS15780	COG3711	transcriptional antiterminator
SB48_RS15785	COG2213	PTS system mannitol-specific
SB48_RS15785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_RS15805	COG0702	epimerase
SB48_RS15830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SB48_RS15840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SB48_RS15860	COG0697	spore germination
SB48_RS15875	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_RS15880	COG0371	Dehydrogenase
SB48_RS15890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SB48_RS15915	COG0175	sulfate reduction
SB48_RS15925	COG5434	Belongs to the glycosyl hydrolase 28 family
SB48_RS15935	COG1012	belongs to the aldehyde dehydrogenase family
SB48_RS15955	COG1309	transcriptional regulator
SB48_RS15965	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS15975	COG1366	Belongs to the anti-sigma-factor antagonist family
SB48_RS15980	COG0217	transcriptional regulatory protein
SB48_RS16005	COG1120	ATPase activity
SB48_RS16010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SB48_RS16015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB48_RS16020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB48_RS16030	COG2076	Multidrug Resistance protein
SB48_RS16035	COG2076	Multidrug Resistance protein
SB48_RS16070	COG0463	Glycosyl transferase, family 2
SB48_RS16075	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SB48_RS16080	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SB48_RS16090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SB48_RS16105	COG2217	Heavy metal translocating P-type atpase
SB48_RS16115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SB48_RS16125	COG0716	FMN binding
SB48_RS16135	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SB48_RS16145	COG1070	Carbohydrate kinase
SB48_RS16155	COG2188	Transcriptional regulator
SB48_RS16160	COG0366	Alpha amylase catalytic
SB48_RS16165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_RS16165	COG1263	PTS System
SB48_RS16170	COG2190	(PTS) system
SB48_RS16175	COG1174	glycine betaine transport
SB48_RS16180	COG0517	IMP dehydrogenase activity
SB48_RS16180	COG1125	glycine betaine transport
SB48_RS16210	COG0183	Belongs to the thiolase family
SB48_RS16245	COG0477	Major facilitator Superfamily
SB48_RS16245	COG2814	Major facilitator Superfamily
SB48_RS16265	COG0519	Catalyzes the synthesis of GMP from XMP
SB48_RS16275	COG2814	Major facilitator Superfamily
SB48_RS16280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB48_RS16340	COG0477	Major facilitator Superfamily
SB48_RS16345	COG0840	transmembrane signaling receptor activity
SB48_RS16355	COG1695	Transcriptional regulator
SB48_RS16370	COG0840	transmembrane signaling receptor activity
SB48_RS16375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SB48_RS16380	COG0583	DNA-binding transcription factor activity
SB48_RS16385	COG2814	Major facilitator Superfamily
SB48_RS16455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SB48_RS16460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SB48_RS16465	COG4856	YbbR-like protein
SB48_RS16470	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SB48_RS16475	COG5662	AntiSigma factor
SB48_RS16480	COG1595	DNA-templated transcription, initiation
SB48_RS16660	COG0305	Participates in initiation and elongation during chromosome replication
SB48_RS16675	COG3723	Recombinational DNA repair protein, rece pathway
SB48_RS16680	COG5377	YqaJ viral recombinase family
SB48_RS16725	COG3620	sequence-specific DNA binding
SB48_RS16805	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SB48_RS16820	COG2010	Cytochrome c
SB48_RS16820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SB48_RS16825	COG0109	protoheme IX farnesyltransferase activity
SB48_RS16835	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_RS16840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SB48_RS16845	COG4988	ABC transporter
SB48_RS16855	COG1294	oxidase, subunit
SB48_RS16860	COG1271	oxidase subunit
SB48_RS16870	COG0726	polysaccharide deacetylase
SB48_RS16880	COG2194	sulfuric ester hydrolase activity
SB48_RS16890	COG0489	protein tyrosine kinase activity
SB48_RS16895	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB48_RS16905	COG0833	amino acid
SB48_RS16910	COG0529	Catalyzes the synthesis of activated sulfate
SB48_RS16915	COG2046	Belongs to the sulfate adenylyltransferase family
SB48_RS16930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SB48_RS16935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SB48_RS16945	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SB48_RS16950	COG1122	ATPase activity
SB48_RS16955	COG1122	ATPase activity
SB48_RS16960	COG0203	ribosomal protein L17
SB48_RS16965	COG0202	RNA polymerase activity
SB48_RS16970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SB48_RS16975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SB48_RS16980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SB48_RS16985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SB48_RS16990	COG0563	adenylate kinase activity
SB48_RS16995	COG0201	protein transport
SB48_RS17000	COG0200	Binds to the 23S rRNA
SB48_RS17010	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SB48_RS17015	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SB48_RS17020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SB48_RS17025	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SB48_RS17030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SB48_RS17040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SB48_RS17045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SB48_RS17050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SB48_RS17055	COG0255	Belongs to the universal ribosomal protein uL29 family
SB48_RS17060	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SB48_RS17065	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SB48_RS17075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SB48_RS17080	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SB48_RS17085	COG0089	rRNA binding
SB48_RS17090	COG0088	Forms part of the polypeptide exit tunnel
SB48_RS17100	COG0051	transcription antitermination factor activity, RNA binding
SB48_RS17105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SB48_RS17110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SB48_RS17115	COG0049	tRNA binding
SB48_RS17120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SB48_RS17125	COG1358	cellular component organization or biogenesis
SB48_RS17140	COG2813	Specifically methylates the guanine in position
SB48_RS17145	COG0222	ribosome binding
SB48_RS17150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SB48_RS17155	COG0081	regulation of translation
SB48_RS17160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SB48_RS17165	COG0250	Participates in transcription elongation, termination and antitermination
SB48_RS17170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SB48_RS17175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SB48_RS17185	COG3688	RNA-binding protein containing a PIN domain
SB48_RS17190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SB48_RS17200	COG0215	cysteine-tRNA ligase activity
SB48_RS17205	COG1045	serine acetyltransferase
SB48_RS17210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SB48_RS17215	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SB48_RS17225	COG4956	integral membrane protein (PIN domain superfamily)
SB48_RS17230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SB48_RS17235	COG0542	response to heat
SB48_RS17240	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SB48_RS17245	COG3880	PFAM UvrB UvrC protein
SB48_RS17295	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SB48_RS17300	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SB48_RS17305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SB48_RS17310	COG0590	tRNA wobble adenosine to inosine editing
SB48_RS17330	COG3858	chitin binding
SB48_RS17330	COG1388	LysM domain
SB48_RS17335	COG1428	Deoxynucleoside kinase
SB48_RS17340	COG1428	Deoxynucleoside kinase
SB48_RS17350	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SB48_RS17355	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SB48_RS17370	COG0516	GMP reductase activity
SB48_RS17370	COG0517	IMP dehydrogenase activity
SB48_RS17440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SB48_RS17450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SB48_RS17455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SB48_RS17460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SB48_RS17465	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SB48_RS17470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SB48_RS17475	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SB48_RS17480	COG0037	tRNA processing
SB48_RS17485	COG0515	serine threonine protein kinase
SB48_RS17490	COG2304	oxidoreductase activity
SB48_RS17495	COG2208	phosphoserine phosphatase activity
SB48_RS17505	COG1098	S1 RNA binding domain
SB48_RS17525	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SB48_RS17530	COG3956	TIGRFAM MazG family protein
SB48_RS17535	COG2244	polysaccharide biosynthetic process
SB48_RS17540	COG2002	toxin-antitoxin pair type II binding
SB48_RS17545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SB48_RS17555	COG0193	aminoacyl-tRNA hydrolase activity
SB48_RS17560	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SB48_RS17565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SB48_RS17570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SB48_RS17600	COG0251	oxidation-reduction process
SB48_RS17605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SB48_RS17610	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SB48_RS17620	COG4466	Protein conserved in bacteria
SB48_RS17635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SB48_RS17645	COG0084	hydrolase, TatD family'
SB48_RS17655	COG2002	toxin-antitoxin pair type II binding
SB48_RS17660	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SB48_RS17665	COG2827	Endonuclease containing a URI domain
SB48_RS17670	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SB48_RS17675	COG4467	Involved in initiation control of chromosome replication
SB48_RS17680	COG1774	PSP1 C-terminal conserved region
SB48_RS17685	COG0470	DNA polymerase III
SB48_RS17690	COG1728	Protein conserved in bacteria
SB48_RS17695	COG3870	Protein conserved in bacteria
SB48_RS17705	COG1982	Orn Lys Arg decarboxylase major
SB48_RS17725	COG3437	response regulator, receiver
SB48_RS17730	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SB48_RS17735	COG0187	DNA topoisomerase II activity
SB48_RS17745	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SB48_RS17750	COG2501	S4 domain
SB48_RS17755	COG0592	DNA-directed DNA polymerase activity
SB48_RS17800	COG1131	(ABC) transporter
SB48_RS17815	COG2176	DNA-directed DNA polymerase activity
SB48_RS17830	COG3953	SLT domain
SB48_RS17830	COG5280	Phage tail tape measure protein TP901
SB48_RS17835	COG1388	LysM domain
SB48_RS17835	COG0791	NLP P60 protein
SB48_RS17870	COG3942	CHAP domain
SB48_RS17870	COG1388	LysM domain
SB48_RS17885	COG3935	DnaD domain protein
SB48_RS18250	COG1024	Enoyl-CoA hydratase
SB48_RS18470	COG1525	nuclease
SB48_RS18515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_RS18520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_RS18550	COG0492	ferredoxin-NADP+ reductase activity