locus-tag	class	description
C3766_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C3766_RS00010	COG0592	DNA-directed DNA polymerase activity
C3766_RS00015	COG2501	S4 domain
C3766_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C3766_RS00030	COG0187	DNA topoisomerase II activity
C3766_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3766_RS00040	COG3437	response regulator, receiver
C3766_RS00075	COG1982	Orn Lys Arg decarboxylase major
C3766_RS00085	COG3870	Protein conserved in bacteria
C3766_RS00090	COG1728	Protein conserved in bacteria
C3766_RS00095	COG0470	DNA polymerase III
C3766_RS00100	COG1774	PSP1 C-terminal conserved region
C3766_RS00105	COG4467	Involved in initiation control of chromosome replication
C3766_RS00110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C3766_RS00115	COG2827	Endonuclease containing a URI domain
C3766_RS00120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C3766_RS00125	COG2002	toxin-antitoxin pair type II binding
C3766_RS00135	COG0084	hydrolase, TatD family'
C3766_RS00145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C3766_RS00160	COG4466	Protein conserved in bacteria
C3766_RS00175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3766_RS00180	COG0251	oxidation-reduction process
C3766_RS00200	COG1136	(ABC) transporter
C3766_RS00200	COG0577	efflux transmembrane transporter activity
C3766_RS00210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C3766_RS00215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C3766_RS00220	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C3766_RS00235	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C3766_RS00240	COG2002	toxin-antitoxin pair type II binding
C3766_RS00245	COG2244	polysaccharide biosynthetic process
C3766_RS00250	COG3956	TIGRFAM MazG family protein
C3766_RS00255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C3766_RS00275	COG1098	S1 RNA binding domain
C3766_RS00305	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C3766_RS00310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C3766_RS00315	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C3766_RS00320	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C3766_RS00325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C3766_RS00330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C3766_RS00335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C3766_RS00340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C3766_RS00420	COG0517	IMP dehydrogenase activity
C3766_RS00420	COG0516	GMP reductase activity
C3766_RS00435	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C3766_RS00445	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C3766_RS00455	COG1428	Deoxynucleoside kinase
C3766_RS00460	COG1428	Deoxynucleoside kinase
C3766_RS00465	COG1388	LysM domain
C3766_RS00465	COG3858	chitin binding
C3766_RS00475	COG0590	tRNA wobble adenosine to inosine editing
C3766_RS00485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C3766_RS00490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C3766_RS00495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C3766_RS00545	COG3880	PFAM UvrB UvrC protein
C3766_RS00550	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C3766_RS00555	COG0542	response to heat
C3766_RS00560	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C3766_RS00565	COG4956	integral membrane protein (PIN domain superfamily)
C3766_RS00575	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C3766_RS00585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C3766_RS00590	COG1045	serine acetyltransferase
C3766_RS00595	COG0215	cysteine-tRNA ligase activity
C3766_RS00605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3766_RS00610	COG3688	RNA-binding protein containing a PIN domain
C3766_RS00620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3766_RS00625	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3766_RS00630	COG0250	Participates in transcription elongation, termination and antitermination
C3766_RS00635	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C3766_RS00640	COG0081	regulation of translation
C3766_RS00645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C3766_RS00650	COG0222	ribosome binding
C3766_RS00655	COG2813	Specifically methylates the guanine in position
C3766_RS00670	COG1358	cellular component organization or biogenesis
C3766_RS00675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C3766_RS00680	COG0049	tRNA binding
C3766_RS00685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C3766_RS00690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C3766_RS00695	COG0051	transcription antitermination factor activity, RNA binding
C3766_RS00705	COG0088	Forms part of the polypeptide exit tunnel
C3766_RS00710	COG0089	rRNA binding
C3766_RS00715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C3766_RS00720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C3766_RS00730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C3766_RS00735	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C3766_RS00740	COG0255	Belongs to the universal ribosomal protein uL29 family
C3766_RS00745	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C3766_RS00750	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C3766_RS00755	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C3766_RS00765	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3766_RS00770	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C3766_RS00775	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C3766_RS00780	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C3766_RS00785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C3766_RS00795	COG0200	Binds to the 23S rRNA
C3766_RS00800	COG0201	protein transport
C3766_RS00805	COG0563	adenylate kinase activity
C3766_RS00810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C3766_RS00815	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C3766_RS00820	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C3766_RS00825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C3766_RS00830	COG0202	RNA polymerase activity
C3766_RS00835	COG0203	ribosomal protein L17
C3766_RS00840	COG1122	ATPase activity
C3766_RS00845	COG1122	ATPase activity
C3766_RS00850	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C3766_RS00860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C3766_RS00865	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C3766_RS00885	COG2046	Belongs to the sulfate adenylyltransferase family
C3766_RS00890	COG0529	Catalyzes the synthesis of activated sulfate
C3766_RS00895	COG0833	amino acid
C3766_RS00905	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3766_RS00910	COG0489	protein tyrosine kinase activity
C3766_RS00920	COG2194	sulfuric ester hydrolase activity
C3766_RS00940	COG0726	polysaccharide deacetylase
C3766_RS00950	COG1271	oxidase subunit
C3766_RS00955	COG1294	oxidase, subunit
C3766_RS00960	COG4988	ABC transporter
C3766_RS00965	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C3766_RS01045	COG1595	DNA-templated transcription, initiation
C3766_RS01050	COG5662	AntiSigma factor
C3766_RS01055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C3766_RS01060	COG4856	YbbR-like protein
C3766_RS01065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3766_RS01070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3766_RS01115	COG2814	Major facilitator Superfamily
C3766_RS01120	COG0583	DNA-binding transcription factor activity
C3766_RS01135	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C3766_RS01140	COG0840	transmembrane signaling receptor activity
C3766_RS01155	COG1695	Transcriptional regulator
C3766_RS01165	COG0840	transmembrane signaling receptor activity
C3766_RS01170	COG0477	Major facilitator Superfamily
C3766_RS01225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3766_RS01230	COG2814	Major facilitator Superfamily
C3766_RS01245	COG0519	Catalyzes the synthesis of GMP from XMP
C3766_RS01265	COG2814	Major facilitator Superfamily
C3766_RS01265	COG0477	Major facilitator Superfamily
C3766_RS01300	COG3425	synthase
C3766_RS01315	COG0183	Belongs to the thiolase family
C3766_RS01340	COG0517	IMP dehydrogenase activity
C3766_RS01340	COG1125	glycine betaine transport
C3766_RS01345	COG1174	glycine betaine transport
C3766_RS01350	COG2190	(PTS) system
C3766_RS01355	COG1263	PTS System
C3766_RS01355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3766_RS01360	COG0366	Alpha amylase catalytic
C3766_RS01365	COG2188	Transcriptional regulator
C3766_RS01375	COG1070	Carbohydrate kinase
C3766_RS01385	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C3766_RS01390	COG0716	FMN binding
C3766_RS01395	COG0322	excinuclease ABC activity
C3766_RS01400	COG2205	protein histidine kinase activity
C3766_RS01405	COG0745	RESPONSE REGULATOR receiver
C3766_RS01415	COG1131	(ABC) transporter
C3766_RS01435	COG2608	mercury ion transmembrane transporter activity
C3766_RS01445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3766_RS01455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3766_RS01460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C3766_RS01465	COG0463	Glycosyl transferase, family 2
C3766_RS01495	COG2076	Multidrug Resistance protein
C3766_RS01500	COG2076	Multidrug Resistance protein
C3766_RS01510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3766_RS01515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3766_RS01520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C3766_RS01530	COG1120	ATPase activity
C3766_RS01560	COG0217	transcriptional regulatory protein
C3766_RS01565	COG1366	Belongs to the anti-sigma-factor antagonist family
C3766_RS01575	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS01585	COG1309	transcriptional regulator
C3766_RS01605	COG1012	belongs to the aldehyde dehydrogenase family
C3766_RS01615	COG5434	Belongs to the glycosyl hydrolase 28 family
C3766_RS01625	COG0175	sulfate reduction
C3766_RS01655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3766_RS01660	COG0371	Dehydrogenase
C3766_RS01665	COG0318	PFAM AMP-dependent synthetase and ligase
C3766_RS01680	COG0697	spore germination
C3766_RS01700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C3766_RS01710	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C3766_RS01735	COG0702	epimerase
C3766_RS01750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C3766_RS01770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3766_RS01770	COG2213	PTS system mannitol-specific
C3766_RS01775	COG3711	transcriptional antiterminator
C3766_RS01780	COG0246	Mannitol dehydrogenase
C3766_RS01785	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C3766_RS01800	COG2848	UPF0210 protein
C3766_RS01805	COG3344	reverse transcriptase
C3766_RS01810	COG1609	Transcriptional regulator
C3766_RS01820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3766_RS01835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C3766_RS01845	COG5577	PFAM Coat F domain
C3766_RS01855	COG0667	Aldo Keto reductase
C3766_RS01865	COG1113	amino acid transport
C3766_RS01875	COG3104	oligopeptide transport
C3766_RS01880	COG0833	amino acid
C3766_RS01900	COG3842	ATPase activity
C3766_RS01905	COG1176	ABC-type spermidine putrescine transport system, permease component I
C3766_RS01950	COG0531	amino acid
C3766_RS01955	COG1556	Lactate utilization protein
C3766_RS01960	COG1139	Iron-sulfur cluster binding protein
C3766_RS01965	COG0247	lactate metabolic process
C3766_RS01975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3766_RS01980	COG1454	alcohol dehydrogenase
C3766_RS01990	COG1953	Uracil, thiamine, allantoin
C3766_RS02015	COG0531	amino acid
C3766_RS02020	COG1979	alcohol dehydrogenase
C3766_RS02025	COG0004	ammonium transporteR
C3766_RS02030	COG3290	protein histidine kinase activity
C3766_RS02035	COG4565	transcriptional regulatory protein
C3766_RS02040	COG2851	Citrate transporter
C3766_RS02050	COG3973	AAA domain
C3766_RS02085	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C3766_RS02095	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C3766_RS02100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C3766_RS02105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C3766_RS02110	COG1301	dicarboxylic acid transport
C3766_RS02115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3766_RS02150	COG1902	pentaerythritol trinitrate reductase activity
C3766_RS02170	COG0423	glycine-tRNA ligase activity
C3766_RS02180	COG0531	amino acid
C3766_RS02190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C3766_RS02200	COG0628	permease
C3766_RS02215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3766_RS02220	COG0765	amino acid transport
C3766_RS02225	COG0765	amino acid transport
C3766_RS02240	COG1733	regulation of RNA biosynthetic process
C3766_RS02255	COG0586	Pfam SNARE associated Golgi protein
C3766_RS02260	COG0586	Pfam SNARE associated Golgi protein
C3766_RS02275	COG0646	methionine synthase
C3766_RS02275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C3766_RS02280	COG0646	methionine synthase
C3766_RS02280	COG1410	methionine synthase
C3766_RS02310	COG3944	biosynthesis protein
C3766_RS02315	COG0489	protein tyrosine kinase activity
C3766_RS02320	COG4464	protein tyrosine phosphatase activity
C3766_RS02325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3766_RS02330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C3766_RS02340	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C3766_RS02340	COG1215	transferase activity, transferring glycosyl groups
C3766_RS02375	COG1091	dTDP-4-dehydrorhamnose reductase activity
C3766_RS02385	COG1196	nuclear chromosome segregation
C3766_RS02395	COG1501	Belongs to the glycosyl hydrolase 31 family
C3766_RS02405	COG2115	Belongs to the xylose isomerase family
C3766_RS02410	COG1070	Carbohydrate kinase
C3766_RS02440	COG1070	Carbohydrate kinase
C3766_RS02470	COG1063	alcohol dehydrogenase
C3766_RS02475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C3766_RS02500	COG2814	Major facilitator Superfamily
C3766_RS02510	COG3254	rhamnose metabolic process
C3766_RS02515	COG4806	L-rhamnose isomerase
C3766_RS02520	COG0235	Class ii aldolase
C3766_RS02525	COG1454	alcohol dehydrogenase
C3766_RS02530	COG4193	domain, Protein
C3766_RS02535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C3766_RS02540	COG0463	Glycosyl transferase, family 2
C3766_RS02555	COG5504	Zn-dependent protease
C3766_RS02560	COG2226	methyltransferase
C3766_RS02570	COG5263	repeat protein
C3766_RS02570	COG0366	Alpha amylase catalytic
C3766_RS02595	COG3711	transcriptional antiterminator
C3766_RS02595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3766_RS02610	COG3730	PTS system glucitol sorbitol-specific
C3766_RS02615	COG3732	PTS system glucitol sorbitol-specific
C3766_RS02625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3766_RS02630	COG1396	sequence-specific DNA binding
C3766_RS02635	COG1609	Transcriptional regulator
C3766_RS02645	COG1129	ABC transporter
C3766_RS02650	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3766_RS02655	COG1879	ABC-type sugar transport system periplasmic component
C3766_RS02660	COG1070	Carbohydrate kinase
C3766_RS02670	COG0235	Class ii aldolase
C3766_RS02690	COG0191	fructose-bisphosphate aldolase activity
C3766_RS02695	COG3414	Phosphotransferase system galactitol-specific IIB component
C3766_RS02740	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C3766_RS02750	COG0145	ligase activity
C3766_RS02760	COG2315	Protein conserved in bacteria
C3766_RS02770	COG2333	competence protein COMEC
C3766_RS02770	COG0658	competence protein
C3766_RS02810	COG0531	amino acid
C3766_RS02820	COG1316	TRANSCRIPTIONal
C3766_RS02830	COG4989	oxidoreductase activity
C3766_RS02865	COG2130	NADP-dependent
C3766_RS02875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3766_RS02875	COG3711	transcriptional antiterminator
C3766_RS02880	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3766_RS02885	COG1447	Phosphotransferase system cellobiose-specific component IIA
C3766_RS02895	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3766_RS02900	COG2190	(PTS) system
C3766_RS02900	COG2211	Major facilitator Superfamily
C3766_RS02905	COG1113	amino acid transport
C3766_RS02925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C3766_RS02930	COG2814	Major facilitator Superfamily
C3766_RS02940	COG2814	Major facilitator Superfamily
C3766_RS02950	COG1609	Transcriptional regulator
C3766_RS02970	COG1732	Glycine betaine
C3766_RS02975	COG1174	glycine betaine transport
C3766_RS02980	COG0517	IMP dehydrogenase activity
C3766_RS02980	COG1125	glycine betaine transport
C3766_RS02985	COG1510	regulation of RNA biosynthetic process
C3766_RS02990	COG0110	maltose O-acetyltransferase activity
C3766_RS03010	COG4297	protein containing double-stranded beta helix domain
C3766_RS03020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3766_RS03030	COG2272	Belongs to the type-B carboxylesterase lipase family
C3766_RS03035	COG0606	chelatase, subunit chli
C3766_RS03045	COG0371	Dehydrogenase
C3766_RS03055	COG0157	Belongs to the NadC ModD family
C3766_RS03060	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C3766_RS03065	COG1104	cysteine desulfurase activity
C3766_RS03075	COG2116	formate transmembrane transporter activity
C3766_RS03080	COG0840	transmembrane signaling receptor activity
C3766_RS03095	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS03100	COG2610	gluconate transmembrane transporter activity
C3766_RS03110	COG1012	belongs to the aldehyde dehydrogenase family
C3766_RS03130	COG1501	Belongs to the glycosyl hydrolase 31 family
C3766_RS03140	COG1960	acyl-CoA dehydrogenase activity
C3766_RS03155	COG1309	transcriptional regulator
C3766_RS03170	COG1363	Peptidase, m42
C3766_RS03210	COG2972	Histidine kinase
C3766_RS03230	COG0531	amino acid
C3766_RS03240	COG1620	l-lactate permease
C3766_RS03245	COG2186	Transcriptional regulator
C3766_RS03275	COG0473	3-isopropylmalate dehydrogenase activity
C3766_RS03310	COG1447	Phosphotransferase system cellobiose-specific component IIA
C3766_RS03325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3766_RS03325	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C3766_RS03330	COG2723	6-phospho-beta-galactosidase activity
C3766_RS03335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3766_RS03335	COG3711	transcriptional antiterminator
C3766_RS03340	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C3766_RS03380	COG0626	cystathionine gamma-synthase activity
C3766_RS03385	COG0626	cystathionine gamma-synthase activity
C3766_RS03405	COG1653	transport
C3766_RS03410	COG2207	Transcriptional regulator
C3766_RS03425	COG0604	alcohol dehydrogenase
C3766_RS03430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C3766_RS03435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C3766_RS03455	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS03460	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C3766_RS03470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C3766_RS03480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3766_RS03485	COG1316	TRANSCRIPTIONal
C3766_RS03495	COG1136	(ABC) transporter
C3766_RS03500	COG1136	(ABC) transporter
C3766_RS03500	COG0577	efflux transmembrane transporter activity
C3766_RS03505	COG0745	RESPONSE REGULATOR receiver
C3766_RS03510	COG5002	protein histidine kinase activity
C3766_RS03520	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C3766_RS03535	COG3584	3D domain protein
C3766_RS03535	COG1388	LysM domain
C3766_RS03545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C3766_RS03555	COG0011	TIGRFAM Protein of
C3766_RS03560	COG2706	6-phosphogluconolactonase activity
C3766_RS03570	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C3766_RS03570	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C3766_RS03575	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3766_RS03575	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3766_RS03585	COG3715	PTS system
C3766_RS03590	COG3716	PTS system mannose fructose sorbose family IID component
C3766_RS03605	COG2079	MmgE PrpD family protein
C3766_RS03610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C3766_RS03620	COG0154	amidase activity
C3766_RS03630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3766_RS03635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3766_RS03640	COG1116	anion transmembrane transporter activity
C3766_RS03645	COG0083	homoserine kinase activity
C3766_RS03650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C3766_RS03655	COG0460	homoserine dehydrogenase
C3766_RS03660	COG0010	Belongs to the arginase family
C3766_RS03670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C3766_RS03675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C3766_RS03685	COG4145	pantothenate transmembrane transporter activity
C3766_RS03700	COG1012	belongs to the aldehyde dehydrogenase family
C3766_RS03700	COG1454	alcohol dehydrogenase
C3766_RS03720	COG1388	LysM domain
C3766_RS03720	COG0791	NLP P60 protein
C3766_RS03725	COG0024	Methionine aminopeptidase
C3766_RS03730	COG1268	BioY protein
C3766_RS03745	COG1960	acyl-CoA dehydrogenase activity
C3766_RS03750	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS03755	COG2746	aminoglycoside 3-N-acetyltransferase activity
C3766_RS03760	COG2244	polysaccharide biosynthetic process
C3766_RS03765	COG0589	response to stress
C3766_RS03780	COG0535	radical SAM domain protein
C3766_RS03790	COG0457	Tetratricopeptide repeat
C3766_RS03795	COG1063	alcohol dehydrogenase
C3766_RS03810	COG1609	Transcriptional regulator
C3766_RS03820	COG0561	phosphatase activity
C3766_RS03840	COG0656	L-ascorbic acid biosynthetic process
C3766_RS03855	COG0656	L-ascorbic acid biosynthetic process
C3766_RS03860	COG0431	NADPH-dependent FMN reductase
C3766_RS03870	COG3620	sequence-specific DNA binding
C3766_RS03875	COG0420	3'-5' exonuclease activity
C3766_RS03880	COG4717	serine-type aminopeptidase activity
C3766_RS03885	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3766_RS03890	COG0534	Mate efflux family protein
C3766_RS03910	COG1664	Polymer-forming cytoskeletal
C3766_RS03920	COG0789	Transcriptional regulator
C3766_RS03925	COG0436	Aminotransferase
C3766_RS03930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C3766_RS03940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C3766_RS03950	COG2226	methyltransferase
C3766_RS03975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C3766_RS04010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C3766_RS04015	COG1113	amino acid transport
C3766_RS04020	COG2814	Major facilitator Superfamily
C3766_RS04040	COG1033	growth of symbiont in host cell
C3766_RS04040	COG2409	Drug exporters of the RND superfamily
C3766_RS04045	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C3766_RS04060	COG1960	acyl-CoA dehydrogenase activity
C3766_RS04080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C3766_RS04085	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C3766_RS04100	COG1609	Transcriptional regulator
C3766_RS04115	COG2996	Protein conserved in bacteria
C3766_RS04120	COG0346	lactoylglutathione lyase activity
C3766_RS04135	COG0477	Major facilitator Superfamily
C3766_RS04140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C3766_RS04150	COG2188	Transcriptional regulator
C3766_RS04155	COG0791	NLP P60 protein
C3766_RS04155	COG1388	LysM domain
C3766_RS04165	COG0768	penicillin binding
C3766_RS04175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3766_RS04180	COG1739	Uncharacterized protein family UPF0029
C3766_RS04190	COG2197	response regulator
C3766_RS04195	COG0531	amino acid
C3766_RS04200	COG1307	EDD domain protein, DegV family
C3766_RS04205	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C3766_RS04210	COG1040	competence protein
C3766_RS04220	COG2747	anti-sigma28 factor FlgM
C3766_RS04230	COG4786	Flagellar basal body rod
C3766_RS04230	COG1256	bacterial-type flagellum assembly
C3766_RS04235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C3766_RS04245	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C3766_RS04250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C3766_RS04255	COG0463	Glycosyl transferase, family 2
C3766_RS04255	COG0457	Tetratricopeptide repeat
C3766_RS04275	COG2094	Belongs to the DNA glycosylase MPG family
C3766_RS04290	COG1334	flagellar protein FlaG
C3766_RS04295	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C3766_RS04300	COG1516	flagellar protein fliS
C3766_RS04325	COG0653	protein targeting
C3766_RS04335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3766_RS04345	COG2884	Cell division ATP-binding protein ftsE
C3766_RS04350	COG2177	Part of the ABC transporter FtsEX involved in
C3766_RS04355	COG0739	heme binding
C3766_RS04370	COG0460	homoserine dehydrogenase
C3766_RS04380	COG3409	Peptidoglycan-binding domain 1 protein
C3766_RS04380	COG0793	Belongs to the peptidase S41A family
C3766_RS04390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3766_RS04395	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3766_RS04400	COG4605	iron ion homeostasis
C3766_RS04405	COG4604	ABC transporter, ATP-binding protein
C3766_RS04410	COG4607	ABC-type enterochelin transport system periplasmic component
C3766_RS04425	COG0745	RESPONSE REGULATOR receiver
C3766_RS04430	COG5002	protein histidine kinase activity
C3766_RS04435	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C3766_RS04445	COG0573	inorganic phosphate transmembrane transporter activity
C3766_RS04450	COG0581	inorganic phosphate transmembrane transporter activity
C3766_RS04460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3766_RS04465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C3766_RS04510	COG0556	nucleotide-excision repair
C3766_RS04515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C3766_RS04520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C3766_RS04530	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C3766_RS04535	COG1682	transport, permease protein
C3766_RS04540	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C3766_RS04540	COG0463	Glycosyl transferase, family 2
C3766_RS04545	COG3595	metallopeptidase activity
C3766_RS04555	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C3766_RS04565	COG0546	phosphoglycolate phosphatase activity
C3766_RS04570	COG0110	maltose O-acetyltransferase activity
C3766_RS04575	COG0457	Tetratricopeptide repeat
C3766_RS04580	COG0492	ferredoxin-NADP+ reductase activity
C3766_RS04585	COG1051	belongs to the nudix hydrolase family
C3766_RS04590	COG1660	Displays ATPase and GTPase activities
C3766_RS04595	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C3766_RS04600	COG1481	regulation of sporulation
C3766_RS04605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3766_RS04640	COG3842	ATPase activity
C3766_RS04645	COG2508	Transcriptional regulator
C3766_RS04655	COG0189	ligase activity
C3766_RS04675	COG4399	Belongs to the UPF0754 family
C3766_RS04685	COG0561	phosphatase activity
C3766_RS04690	COG1024	Enoyl-CoA hydratase
C3766_RS04700	COG0861	Integral membrane protein TerC family
C3766_RS04705	COG0701	Predicted permease
C3766_RS04710	COG3689	TIGRFAM TIGR03943 family protein
C3766_RS04715	COG0420	3'-5' exonuclease activity
C3766_RS04720	COG4717	serine-type aminopeptidase activity
C3766_RS04725	COG3481	metal-dependent phosphohydrolase, HD sub domain
C3766_RS04735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C3766_RS04750	COG1846	Transcriptional regulator
C3766_RS04770	COG0537	adenosine 5'-monophosphoramidase activity
C3766_RS04775	COG1131	(ABC) transporter
C3766_RS04780	COG4473	ABC transporter
C3766_RS04790	COG1473	amidohydrolase
C3766_RS04795	COG3069	C4-dicarboxylate transmembrane transporter activity
C3766_RS04800	COG2329	Antibiotic biosynthesis monooxygenase
C3766_RS04805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C3766_RS04820	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C3766_RS04825	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C3766_RS04835	COG1309	transcriptional regulator
C3766_RS04840	COG1511	domain protein
C3766_RS04845	COG2190	(PTS) system
C3766_RS04845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3766_RS04845	COG1263	PTS System
C3766_RS04845	COG2190	(PTS) system
C3766_RS04845	COG1263	PTS System
C3766_RS04845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3766_RS04850	COG1349	DNA-binding transcription factor activity
C3766_RS04855	COG3254	rhamnose metabolic process
C3766_RS04860	COG2814	Major facilitator Superfamily
C3766_RS04865	COG0697	spore germination
C3766_RS04870	COG1012	belongs to the aldehyde dehydrogenase family
C3766_RS04875	COG1999	signal sequence binding
C3766_RS04890	COG0095	Lipoate-protein ligase
C3766_RS04895	COG0318	PFAM AMP-dependent synthetase and ligase
C3766_RS04905	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C3766_RS04915	COG0501	Belongs to the peptidase M48B family
C3766_RS04940	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C3766_RS04980	COG2311	Membrane
C3766_RS04985	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3766_RS05000	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS05005	COG1307	EDD domain protein, DegV family
C3766_RS05015	COG0561	phosphatase activity
C3766_RS05020	COG2151	metal-sulfur cluster biosynthetic enzyme
C3766_RS05050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3766_RS05055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3766_RS05070	COG4608	Belongs to the ABC transporter superfamily
C3766_RS05075	COG0601	transmembrane transport
C3766_RS05085	COG0747	negative chemotaxis
C3766_RS05095	COG0180	Tryptophanyl-tRNA synthetase
C3766_RS05105	COG4166	transmembrane transport
C3766_RS05110	COG0601	transmembrane transport
C3766_RS05115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3766_RS05120	COG0444	Belongs to the ABC transporter superfamily
C3766_RS05125	COG4608	Belongs to the ABC transporter superfamily
C3766_RS05130	COG1393	Belongs to the ArsC family
C3766_RS05140	COG4862	establishment of competence for transformation
C3766_RS05145	COG4469	Competence protein
C3766_RS05150	COG1164	Oligoendopeptidase f
C3766_RS05165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C3766_RS05170	COG2346	COG2346, Truncated hemoglobins
C3766_RS05185	COG0741	lytic transglycosylase activity
C3766_RS05200	COG2357	RelA SpoT domain protein
C3766_RS05210	COG0564	pseudouridine synthase activity
C3766_RS05220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C3766_RS05225	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C3766_RS05260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C3766_RS05305	COG2153	protein acetylation
C3766_RS05315	COG2382	esterase
C3766_RS05345	COG1940	carbohydrate kinase activity
C3766_RS05355	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS05360	COG4152	abc transporter atp-binding protein
C3766_RS05365	COG1668	transmembrane transport
C3766_RS05380	COG3579	cysteine-type endopeptidase activity
C3766_RS05405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3766_RS05410	COG2059	Chromate
C3766_RS05415	COG2059	Chromate
C3766_RS05420	COG1522	sequence-specific DNA binding
C3766_RS05435	COG0154	amidase activity
C3766_RS05465	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C3766_RS05470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3766_RS05490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C3766_RS05515	COG1609	Transcriptional regulator
C3766_RS05525	COG1554	hydrolase, family 65, central catalytic
C3766_RS05530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3766_RS05570	COG0477	Major facilitator Superfamily
C3766_RS05580	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS05620	COG1959	2 iron, 2 sulfur cluster binding
C3766_RS05640	COG0783	Belongs to the Dps family
C3766_RS05645	COG0673	inositol 2-dehydrogenase activity
C3766_RS05650	COG3852	Histidine kinase
C3766_RS05655	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C3766_RS05665	COG0861	Integral membrane protein TerC family
C3766_RS05675	COG5002	protein histidine kinase activity
C3766_RS05680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C3766_RS05700	COG0542	response to heat
C3766_RS05705	COG3949	Membrane
C3766_RS05720	COG4873	Protein conserved in bacteria
C3766_RS05735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3766_RS05750	COG2084	Dehydrogenase
C3766_RS05755	COG0436	Aminotransferase
C3766_RS05760	COG0835	chemotaxis
C3766_RS05760	COG0784	Response regulator, receiver
C3766_RS05770	COG1033	growth of symbiont in host cell
C3766_RS05770	COG2409	Drug exporters of the RND superfamily
C3766_RS05790	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS05800	COG4703	Protein of unknown function (DUF1797)
C3766_RS05805	COG0517	IMP dehydrogenase activity
C3766_RS05810	COG0583	DNA-binding transcription factor activity
C3766_RS05815	COG2171	N-acyltransferase activity
C3766_RS05820	COG1473	amidohydrolase
C3766_RS05835	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C3766_RS05880	COG1982	Orn Lys Arg decarboxylase major
C3766_RS05885	COG4476	Belongs to the UPF0223 family
C3766_RS05900	COG0483	inositol monophosphate 1-phosphatase activity
C3766_RS05910	COG1217	gtp-binding protein TYPA
C3766_RS05920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C3766_RS05925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C3766_RS05930	COG4838	Belongs to the UPF0358 family
C3766_RS05935	COG0772	Belongs to the SEDS family
C3766_RS05940	COG1612	heme a metabolic process
C3766_RS05945	COG0109	protoheme IX farnesyltransferase activity
C3766_RS05950	COG2010	Cytochrome c
C3766_RS05950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C3766_RS05965	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C3766_RS05970	COG3336	cytochrome c oxidase
C3766_RS05980	COG2340	Cysteine-rich secretory protein family
C3766_RS05985	COG2050	protein possibly involved in aromatic compounds catabolism
C3766_RS06015	COG3679	Belongs to the UPF0342 family
C3766_RS06020	COG4471	UPF0298 protein
C3766_RS06035	COG0742	ribosomal rna small subunit methyltransferase
C3766_RS06045	COG3314	Sporulation integral membrane protein YlbJ
C3766_RS06050	COG1752	Esterase of the alpha-beta hydrolase superfamily
C3766_RS06055	COG3480	Lon protease (S16) C-terminal proteolytic domain
C3766_RS06065	COG1323	Belongs to the UPF0348 family
C3766_RS06070	COG1399	metal-binding, possibly nucleic acid-binding protein
C3766_RS06075	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C3766_RS06085	COG0454	-acetyltransferase
C3766_RS06090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C3766_RS06095	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C3766_RS06105	COG2001	Belongs to the MraZ family
C3766_RS06110	COG0275	rRNA processing
C3766_RS06115	COG4839	cell division protein FtsL
C3766_RS06120	COG0768	penicillin binding
C3766_RS06125	COG0768	penicillin binding
C3766_RS06140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C3766_RS06145	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C3766_RS06150	COG0772	Belongs to the SEDS family
C3766_RS06155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3766_RS06160	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C3766_RS06165	COG0849	cell division
C3766_RS06170	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C3766_RS06185	COG1191	sigma factor activity
C3766_RS06190	COG1191	sigma factor activity
C3766_RS06195	COG1873	PFAM PRC-barrel domain
C3766_RS06200	COG3584	3D domain protein
C3766_RS06200	COG1388	LysM domain
C3766_RS06210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C3766_RS06215	COG1799	cell septum assembly
C3766_RS06220	COG0762	integral membrane protein
C3766_RS06225	COG2302	S4 RNA-binding domain
C3766_RS06230	COG3599	regulation of cell shape
C3766_RS06255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C3766_RS06260	COG0564	pseudouridine synthase activity
C3766_RS06270	COG0540	Belongs to the ATCase OTCase family
C3766_RS06275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C3766_RS06295	COG0167	dihydroorotate dehydrogenase activity
C3766_RS06300	COG0284	orotidine-5'-phosphate decarboxylase activity
C3766_RS06305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C3766_RS06345	COG1917	Cupin 2, conserved barrel domain protein
C3766_RS06345	COG2207	Transcriptional regulator
C3766_RS06350	COG1070	Carbohydrate kinase
C3766_RS06355	COG4806	L-rhamnose isomerase
C3766_RS06360	COG0235	Class ii aldolase
C3766_RS06365	COG1454	alcohol dehydrogenase
C3766_RS06370	COG1803	Methylglyoxal synthase
C3766_RS06375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C3766_RS06380	COG0477	Major facilitator Superfamily
C3766_RS06385	COG0477	Major facilitator Superfamily
C3766_RS06390	COG1309	transcriptional regulator
C3766_RS06405	COG0628	permease
C3766_RS06410	COG0561	phosphatase activity
C3766_RS06435	COG0720	synthase
C3766_RS06445	COG0385	Bile acid
C3766_RS06460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C3766_RS06465	COG1561	YicC-like family, N-terminal region
C3766_RS06470	COG2052	Domain of unknown function (DUF370)
C3766_RS06475	COG0194	GDP metabolic process
C3766_RS06480	COG1758	RNA polymerase activity
C3766_RS06485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C3766_RS06490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C3766_RS06495	COG0242	peptide deformylase activity
C3766_RS06500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C3766_RS06505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C3766_RS06505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C3766_RS06510	COG0631	protein serine/threonine phosphatase activity
C3766_RS06515	COG2815	serine threonine protein kinase
C3766_RS06515	COG0515	serine threonine protein kinase
C3766_RS06525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3766_RS06530	COG1564	THIamine pyrophosphokinase
C3766_RS06540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C3766_RS06550	COG1302	Protein conserved in bacteria
C3766_RS06555	COG1461	Dihydroxyacetone kinase
C3766_RS06565	COG1760	l-serine dehydratase
C3766_RS06570	COG1760	l-serine dehydratase
C3766_RS06575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C3766_RS06580	COG1349	DNA-binding transcription factor activity
C3766_RS06585	COG0416	fatty acid biosynthetic process
C3766_RS06590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C3766_RS06595	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS06605	COG0571	ribonuclease III activity
C3766_RS06610	COG1196	nuclear chromosome segregation
C3766_RS06615	COG0552	protein localization to endoplasmic reticulum
C3766_RS06620	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C3766_RS06625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C3766_RS06635	COG1837	Belongs to the UPF0109 family
C3766_RS06645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C3766_RS06650	COG0336	Belongs to the RNA methyltransferase TrmD family
C3766_RS06665	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C3766_RS06680	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C3766_RS06685	COG0045	succinate-CoA ligase (ADP-forming) activity
C3766_RS06690	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C3766_RS06695	COG0758	DNA mediated transformation
C3766_RS06700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3766_RS06715	COG4974	Belongs to the 'phage' integrase family
C3766_RS06720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C3766_RS06730	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C3766_RS06735	COG1815	bacterial-type flagellum-dependent cell motility
C3766_RS06740	COG1558	bacterial-type flagellum-dependent cell motility
C3766_RS06745	COG1677	Flagellar hook-basal body complex protein FliE
C3766_RS06750	COG1766	The M ring may be actively involved in energy transduction
C3766_RS06755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3766_RS06760	COG1317	bacterial-type flagellum organization
C3766_RS06765	COG1157	protein secretion by the type III secretion system
C3766_RS06770	COG2882	bacterial-type flagellum organization
C3766_RS06785	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C3766_RS06795	COG4786	Flagellar basal body rod
C3766_RS06805	COG1580	Controls the rotational direction of flagella during chemotaxis
C3766_RS06810	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3766_RS06815	COG1776	CheC inhibitor of MCP methylation
C3766_RS06815	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C3766_RS06820	COG2201	protein-glutamate methylesterase activity
C3766_RS06825	COG3190	flagellar
C3766_RS06830	COG1338	Plays a role in the flagellum-specific transport system
C3766_RS06835	COG1987	bacterial-type flagellum assembly
C3766_RS06840	COG1684	flagellar biosynthetic protein fliR
C3766_RS06845	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C3766_RS06850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C3766_RS06855	COG1419	protein localization to endoplasmic reticulum
C3766_RS06860	COG0455	bacterial-type flagellum organization
C3766_RS06865	COG2201	protein-glutamate methylesterase activity
C3766_RS06870	COG0643	Histidine kinase
C3766_RS06870	COG2198	Histidine kinase
C3766_RS06875	COG0835	chemotaxis
C3766_RS06880	COG1776	CheC inhibitor of MCP methylation
C3766_RS06885	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C3766_RS06890	COG1191	sigma factor activity
C3766_RS06900	COG0052	Belongs to the universal ribosomal protein uS2 family
C3766_RS06905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C3766_RS06910	COG0528	UMP kinase activity
C3766_RS06915	COG0233	cytoplasmic translational termination
C3766_RS06925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C3766_RS06930	COG4589	Belongs to the CDS family
C3766_RS06940	COG0750	zinc metalloprotease
C3766_RS06945	COG0442	prolyl-tRNA aminoacylation
C3766_RS06950	COG2176	DNA-directed DNA polymerase activity
C3766_RS06955	COG0779	Required for maturation of 30S ribosomal subunits
C3766_RS06960	COG0195	Participates in both transcription termination and antitermination
C3766_RS06965	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C3766_RS06970	COG1358	cellular component organization or biogenesis
C3766_RS06980	COG1550	Protein conserved in bacteria
C3766_RS06985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C3766_RS06990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C3766_RS06995	COG0196	riboflavin kinase activity
C3766_RS07000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C3766_RS07005	COG1185	polyribonucleotide nucleotidyltransferase activity
C3766_RS07010	COG0726	polysaccharide deacetylase
C3766_RS07015	COG0612	Peptidase, M16
C3766_RS07020	COG1873	PFAM PRC-barrel domain
C3766_RS07025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3766_RS07030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C3766_RS07035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C3766_RS07045	COG0527	aspartate kinase activity
C3766_RS07055	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C3766_RS07060	COG0740	serine-type endopeptidase activity
C3766_RS07070	COG4980	gas vesicle protein
C3766_RS07070	COG1674	ftsk spoiiie
C3766_RS07075	COG1744	ABC transporter substrate-binding protein PnrA-like
C3766_RS07080	COG3845	ABC transporter
C3766_RS07085	COG4603	Belongs to the binding-protein-dependent transport system permease family
C3766_RS07090	COG1079	Belongs to the binding-protein-dependent transport system permease family
C3766_RS07095	COG0612	Peptidase, M16
C3766_RS07100	COG0612	Peptidase, M16
C3766_RS07105	COG0300	oxidoreductase activity
C3766_RS07120	COG1426	Protein conserved in bacteria
C3766_RS07125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C3766_RS07130	COG1546	Belongs to the CinA family
C3766_RS07130	COG1058	Belongs to the CinA family
C3766_RS07140	COG1418	mRNA catabolic process
C3766_RS07145	COG1692	metallophosphoesterase
C3766_RS07150	COG2359	stage V sporulation protein S
C3766_RS07155	COG0826	peptidase U32
C3766_RS07160	COG0826	peptidase U32
C3766_RS07170	COG3829	transcription factor binding
C3766_RS07175	COG1012	belongs to the aldehyde dehydrogenase family
C3766_RS07185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3766_RS07190	COG4550	Control of competence regulator ComK, YlbF/YmcA
C3766_RS07200	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C3766_RS07205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C3766_RS07235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C3766_RS07250	COG0464	growth
C3766_RS07255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C3766_RS07260	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C3766_RS07265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3766_RS07285	COG1321	iron dependent repressor
C3766_RS07295	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C3766_RS07305	COG1418	mRNA catabolic process
C3766_RS07310	COG0488	(ABC) transporter
C3766_RS07315	COG1413	lyase activity
C3766_RS07335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C3766_RS07340	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C3766_RS07345	COG1272	protein, Hemolysin III
C3766_RS07350	COG2755	lipolytic protein G-D-S-L family
C3766_RS07360	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C3766_RS07360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C3766_RS07365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3766_RS07370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3766_RS07380	COG0840	transmembrane signaling receptor activity
C3766_RS07385	COG4479	Belongs to the UPF0346 family
C3766_RS07405	COG1876	peptidase activity
C3766_RS07410	COG0793	Belongs to the peptidase S41A family
C3766_RS07410	COG3409	Peptidoglycan-binding domain 1 protein
C3766_RS07415	COG1846	Transcriptional regulator
C3766_RS07420	COG2340	Cysteine-rich secretory protein family
C3766_RS07425	COG0534	Mate efflux family protein
C3766_RS07440	COG1793	dna ligase
C3766_RS07440	COG3285	dna ligase
C3766_RS07445	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C3766_RS07450	COG0671	phosphoesterase, PA-phosphatase related
C3766_RS07455	COG1368	sulfuric ester hydrolase activity
C3766_RS07475	COG2814	Major facilitator Superfamily
C3766_RS07485	COG0745	RESPONSE REGULATOR receiver
C3766_RS07490	COG5002	protein histidine kinase activity
C3766_RS07500	COG0567	Dehydrogenase, E1 component
C3766_RS07505	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3766_RS07510	COG1012	belongs to the aldehyde dehydrogenase family
C3766_RS07530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3766_RS07540	COG1054	Belongs to the UPF0176 family
C3766_RS07550	COG2135	peptidase activity
C3766_RS07565	COG0517	IMP dehydrogenase activity
C3766_RS07565	COG0516	GMP reductase activity
C3766_RS07570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3766_RS07570	COG0723	plastoquinol--plastocyanin reductase activity
C3766_RS07575	COG1388	LysM domain
C3766_RS07575	COG3584	3D domain protein
C3766_RS07580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C3766_RS07585	COG1113	amino acid transport
C3766_RS07590	COG1280	lysine exporter protein (LysE YggA)
C3766_RS07595	COG0598	Magnesium transport protein CorA
C3766_RS07605	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C3766_RS07610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C3766_RS07615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C3766_RS07620	COG0131	Imidazoleglycerol-phosphate dehydratase
C3766_RS07625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C3766_RS07635	COG0107	imidazoleglycerol-phosphate synthase activity
C3766_RS07640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C3766_RS07640	COG0140	phosphoribosyl-ATP diphosphatase activity
C3766_RS07650	COG2391	methyltransferase activity
C3766_RS07655	COG2962	Rard protein
C3766_RS07660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C3766_RS07665	COG0569	domain protein
C3766_RS07685	COG2807	transmembrane transport
C3766_RS07690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C3766_RS07700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C3766_RS07710	COG1278	Cold shock
C3766_RS07715	COG3335	DDE superfamily endonuclease
C3766_RS07720	COG0302	gtp cyclohydrolase
C3766_RS07730	COG0492	ferredoxin-NADP+ reductase activity
C3766_RS07745	COG0577	efflux transmembrane transporter activity
C3766_RS07750	COG1136	(ABC) transporter
C3766_RS07755	COG0642	Histidine kinase
C3766_RS07760	COG0745	RESPONSE REGULATOR receiver
C3766_RS07790	COG0640	Transcriptional regulator
C3766_RS07795	COG2814	Major facilitator Superfamily
C3766_RS07800	COG5039	Polysaccharide pyruvyl transferase
C3766_RS07805	COG1113	amino acid transport
C3766_RS07825	COG0477	Major facilitator Superfamily
C3766_RS07835	COG1132	(ABC) transporter
C3766_RS07840	COG1132	(ABC) transporter
C3766_RS07850	COG1380	Effector of murein hydrolase LrgA
C3766_RS07855	COG1346	cytolysis
C3766_RS07860	COG0318	PFAM AMP-dependent synthetase and ligase
C3766_RS07885	COG2309	aminopeptidase activity
C3766_RS07895	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C3766_RS07925	COG4841	protein insertion into membrane
C3766_RS07930	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C3766_RS07935	COG1832	CoA-binding protein
C3766_RS07940	COG0187	DNA topoisomerase II activity
C3766_RS07945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C3766_RS07990	COG2070	2-Nitropropane dioxygenase
C3766_RS08000	COG0681	Belongs to the peptidase S26 family
C3766_RS08010	COG0473	3-isopropylmalate dehydrogenase activity
C3766_RS08020	COG2226	methyltransferase
C3766_RS08045	COG0456	acetyltransferase
C3766_RS08050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C3766_RS08055	COG0456	acetyltransferase
C3766_RS08065	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C3766_RS08070	COG0351	phosphomethylpyrimidine kinase
C3766_RS08080	COG2258	MOSC domain
C3766_RS08115	COG1309	transcriptional regulator
C3766_RS08120	COG2814	Major facilitator Superfamily
C3766_RS08125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3766_RS08130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3766_RS08145	COG1809	phosphosulfolactate synthase activity
C3766_RS08150	COG2045	Belongs to the ComB family
C3766_RS08155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C3766_RS08160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C3766_RS08170	COG0789	Transcriptional regulator
C3766_RS08175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3766_RS08180	COG0697	spore germination
C3766_RS08185	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C3766_RS08190	COG0022	dehydrogenase e1 component
C3766_RS08200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3766_RS08205	COG3284	Transcriptional regulator
C3766_RS08210	COG1511	domain protein
C3766_RS08210	COG3264	Mechanosensitive ion channel
C3766_RS08225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3766_RS08235	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C3766_RS08250	COG0183	Belongs to the thiolase family
C3766_RS08255	COG0318	PFAM AMP-dependent synthetase and ligase
C3766_RS08265	COG0561	phosphatase activity
C3766_RS08270	COG2322	membrane
C3766_RS08285	COG0039	L-malate dehydrogenase activity
C3766_RS08290	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS08295	COG2223	nitrite transmembrane transporter activity
C3766_RS08300	COG3773	Cell wall hydrolase
C3766_RS08310	COG0708	Exodeoxyribonuclease III
C3766_RS08320	COG0297	glycogen (starch) synthase activity
C3766_RS08325	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C3766_RS08330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C3766_RS08335	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C3766_RS08360	COG1247	-acetyltransferase
C3766_RS08365	COG0494	nUDIX hydrolase
C3766_RS08370	COG1914	H( )-stimulated, divalent metal cation uptake system
C3766_RS08375	COG0783	Belongs to the Dps family
C3766_RS08385	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C3766_RS08390	COG1131	(ABC) transporter
C3766_RS08415	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C3766_RS08425	COG2030	dehydratase
C3766_RS08430	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS08435	COG0277	FAD linked oxidase domain protein
C3766_RS08445	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C3766_RS08450	COG0709	Synthesizes selenophosphate from selenide and ATP
C3766_RS08460	COG0701	Predicted permease
C3766_RS08465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C3766_RS08470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C3766_RS08480	COG1252	NADH dehydrogenase
C3766_RS08485	COG2404	hydrolase activity, acting on ester bonds
C3766_RS08495	COG4990	cell redox homeostasis
C3766_RS08500	COG0789	Transcriptional regulator
C3766_RS08525	COG0436	Aminotransferase
C3766_RS08530	COG0165	Argininosuccinate lyase
C3766_RS08535	COG0137	argininosuccinate synthase activity
C3766_RS08540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3766_RS08545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C3766_RS08550	COG0505	Belongs to the CarA family
C3766_RS08555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3766_RS08560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C3766_RS08565	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C3766_RS08570	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C3766_RS08585	COG3546	catalase activity
C3766_RS08605	COG1619	proteins homologs of microcin C7 resistance protein MccF
C3766_RS08610	COG2027	D-alanyl-D-alanine carboxypeptidase
C3766_RS08615	COG0204	Acyl-transferase
C3766_RS08625	COG4846	Membrane protein involved in cytochrome C biogenesis
C3766_RS08630	COG2201	protein-glutamate methylesterase activity
C3766_RS08635	COG0785	Cytochrome C biogenesis protein
C3766_RS08640	COG3763	UPF0154 protein
C3766_RS08655	COG4224	UPF0291 protein
C3766_RS08660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C3766_RS08670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C3766_RS08680	COG0791	NLP P60 protein
C3766_RS08680	COG1388	LysM domain
C3766_RS08725	COG5280	Phage tail tape measure protein TP901
C3766_RS08725	COG3953	SLT domain
C3766_RS08765	COG0740	serine-type endopeptidase activity
C3766_RS08800	COG0582	viral genome integration into host DNA
C3766_RS08805	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C3766_RS08880	COG1396	sequence-specific DNA binding
C3766_RS08890	COG2176	DNA-directed DNA polymerase activity
C3766_RS08910	COG0582	viral genome integration into host DNA
C3766_RS08915	COG0174	glutamine synthetase
C3766_RS08920	COG0789	Transcriptional regulator
C3766_RS08925	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C3766_RS08940	COG2233	PERMEase
C3766_RS08955	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C3766_RS08960	COG0116	Belongs to the methyltransferase superfamily
C3766_RS08975	COG4474	Belongs to the UPF0398 family
C3766_RS08985	COG3359	exonuclease
C3766_RS08990	COG1111	helicase
C3766_RS08990	COG1205	dead DEAH box helicase
C3766_RS08995	COG0071	Belongs to the small heat shock protein (HSP20) family
C3766_RS09020	COG3331	DNA recombination
C3766_RS09025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3766_RS09025	COG4499	WXG100 protein secretion system (Wss), protein YukC
C3766_RS09030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C3766_RS09035	COG3935	DnaD domain protein
C3766_RS09040	COG0017	Asparaginyl-tRNA synthetase
C3766_RS09055	COG1199	ATP-dependent helicase activity
C3766_RS09055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C3766_RS09060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C3766_RS09065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C3766_RS09085	COG0438	transferase activity, transferring glycosyl groups
C3766_RS09090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C3766_RS09095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C3766_RS09100	COG1694	Mazg nucleotide pyrophosphohydrolase
C3766_RS09105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C3766_RS09115	COG2738	Putative neutral zinc metallopeptidase
C3766_RS09125	COG4347	Protein of unknown function (DUF1405)
C3766_RS09135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C3766_RS09150	COG5582	Belongs to the UPF0302 family
C3766_RS09155	COG0457	Tetratricopeptide repeat
C3766_RS09165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C3766_RS09170	COG0287	Prephenate dehydrogenase
C3766_RS09175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C3766_RS09180	COG4401	Chorismate mutase type I
C3766_RS09185	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C3766_RS09190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C3766_RS09195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C3766_RS09200	COG0105	UTP biosynthetic process
C3766_RS09205	COG0142	geranyltranstransferase activity
C3766_RS09210	COG2226	methyltransferase
C3766_RS09215	COG0142	geranyltranstransferase activity
C3766_RS09230	COG0776	regulation of translation
C3766_RS09235	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C3766_RS09255	COG1160	GTP binding
C3766_RS09270	COG0539	negative regulation of cytoplasmic translation
C3766_RS09275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C3766_RS09280	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C3766_RS09285	COG2959	enzyme of heme biosynthesis
C3766_RS09290	COG3773	Cell wall hydrolase
C3766_RS09290	COG3409	Peptidoglycan-binding domain 1 protein
C3766_RS09295	COG2339	peptidase activity
C3766_RS09300	COG0492	ferredoxin-NADP+ reductase activity
C3766_RS09305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C3766_RS09315	COG1408	metallophosphoesterase
C3766_RS09330	COG3546	catalase activity
C3766_RS09345	COG1266	CAAX protease self-immunity
C3766_RS09350	COG0514	ATP-dependent DNA helicase (RecQ)
C3766_RS09360	COG1141	Ferredoxin
C3766_RS09365	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C3766_RS09370	COG0741	lytic transglycosylase activity
C3766_RS09370	COG1196	nuclear chromosome segregation
C3766_RS09370	COG0739	heme binding
C3766_RS09375	COG5002	protein histidine kinase activity
C3766_RS09380	COG0745	RESPONSE REGULATOR receiver
C3766_RS09385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3766_RS09390	COG1333	cytochrome c biogenesis protein
C3766_RS09395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3766_RS09400	COG1187	pseudouridine synthase activity
C3766_RS09405	COG0700	Nucleoside recognition
C3766_RS09410	COG2715	membrane protein required for spore maturation
C3766_RS09415	COG1686	Belongs to the peptidase S11 family
C3766_RS09420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C3766_RS09445	COG0697	spore germination
C3766_RS09465	COG1191	sigma factor activity
C3766_RS09480	COG1686	Belongs to the peptidase S11 family
C3766_RS09485	COG4974	Belongs to the 'phage' integrase family
C3766_RS09495	COG0735	belongs to the Fur family
C3766_RS09500	COG1300	Membrane
C3766_RS09505	COG1379	DNA repair
C3766_RS09520	COG0667	Aldo Keto reductase
C3766_RS09535	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C3766_RS09540	COG3853	Toxic anion resistance protein (TelA)
C3766_RS09545	COG1073	alpha beta
C3766_RS09550	COG1388	LysM domain
C3766_RS09550	COG3858	chitin binding
C3766_RS09560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C3766_RS09565	COG0300	oxidoreductase activity
C3766_RS09575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3766_RS09585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C3766_RS09600	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3766_RS09610	COG1376	ErfK ybiS ycfS ynhG family protein
C3766_RS09620	COG1105	Belongs to the carbohydrate kinase PfkB family
C3766_RS09625	COG0508	dehydrogenase complex catalyzes the overall conversion of
C3766_RS09630	COG0022	dehydrogenase e1 component
C3766_RS09635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C3766_RS09640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C3766_RS09650	COG3829	transcription factor binding
C3766_RS09650	COG3290	protein histidine kinase activity
C3766_RS09660	COG0584	glycerophosphoryl diester phosphodiesterase
C3766_RS09665	COG0745	RESPONSE REGULATOR receiver
C3766_RS09675	COG0750	zinc metalloprotease
C3766_RS09680	COG0497	DNA recombination
C3766_RS09690	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C3766_RS09695	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C3766_RS09710	COG1570	exodeoxyribonuclease VII activity
C3766_RS09725	COG1302	Protein conserved in bacteria
C3766_RS09730	COG0439	Biotin carboxylase
C3766_RS09735	COG0511	ligase activity, forming carbon-carbon bonds
C3766_RS09775	COG3854	ATPases associated with a variety of cellular activities
C3766_RS09780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C3766_RS09785	COG0006	proline dipeptidase activity
C3766_RS09790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C3766_RS09800	COG3872	metal-dependent enzyme
C3766_RS09810	COG1752	Esterase of the alpha-beta hydrolase superfamily
C3766_RS09820	COG3327	negative regulation of DNA-templated transcription, initiation
C3766_RS09825	COG0183	Belongs to the thiolase family
C3766_RS09830	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3766_RS09835	COG1012	belongs to the aldehyde dehydrogenase family
C3766_RS09840	COG1024	Enoyl-CoA hydratase
C3766_RS09875	COG3396	Phenylacetate-CoA oxygenase
C3766_RS09880	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C3766_RS09890	COG0492	ferredoxin-NADP+ reductase activity
C3766_RS09900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C3766_RS09905	COG0095	Lipoate-protein ligase
C3766_RS09910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3766_RS09915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C3766_RS09925	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C3766_RS09930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3766_RS09945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C3766_RS09970	COG4537	Required for transformation and DNA binding
C3766_RS09975	COG1459	type II secretion system
C3766_RS09995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3766_RS10005	COG1940	carbohydrate kinase activity
C3766_RS10010	COG4483	Protein conserved in bacteria
C3766_RS10015	COG0705	Rhomboid family
C3766_RS10015	COG0457	Tetratricopeptide repeat
C3766_RS10025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C3766_RS10035	COG0768	penicillin binding
C3766_RS10040	COG0477	Major facilitator Superfamily
C3766_RS10045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C3766_RS10055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C3766_RS10060	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C3766_RS10065	COG0735	belongs to the Fur family
C3766_RS10070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C3766_RS10075	COG1121	(ABC) transporter
C3766_RS10085	COG3883	PFAM NLP P60 protein
C3766_RS10085	COG0791	NLP P60 protein
C3766_RS10090	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C3766_RS10095	COG0513	Belongs to the DEAD box helicase family
C3766_RS10105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C3766_RS10110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C3766_RS10115	COG2384	SAM-dependent methyltransferase
C3766_RS10120	COG2010	Cytochrome c
C3766_RS10130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C3766_RS10135	COG0358	DNA primase activity
C3766_RS10145	COG0517	IMP dehydrogenase activity
C3766_RS10155	COG1381	Involved in DNA repair and RecF pathway recombination
C3766_RS10170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C3766_RS10175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C3766_RS10180	COG1480	7TM receptor with intracellular HD hydrolase
C3766_RS10185	COG1702	phosphate starvation-inducible protein PhoH
C3766_RS10200	COG1610	YqeY-like protein
C3766_RS10215	COG1283	sodium-dependent phosphate transmembrane transporter activity
C3766_RS10220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C3766_RS10225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C3766_RS10230	COG2264	protein methyltransferase activity
C3766_RS10240	COG0443	Heat shock 70 kDa protein
C3766_RS10245	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C3766_RS10255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C3766_RS10260	COG0481	GTPase activity
C3766_RS10265	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3766_RS10270	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C3766_RS10275	COG0268	Binds directly to 16S ribosomal RNA
C3766_RS10280	COG1466	dna polymerase III delta subunit
C3766_RS10295	COG2131	deaminase
C3766_RS10300	COG1596	polysaccharide export
C3766_RS10300	COG1555	photosystem II stabilization
C3766_RS10305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C3766_RS10310	COG2226	methyltransferase
C3766_RS10315	COG0799	negative regulation of ribosome biogenesis
C3766_RS10320	COG1713	HD superfamily hydrolase involved in NAD metabolism
C3766_RS10325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C3766_RS10330	COG1534	Rna-binding protein
C3766_RS10335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C3766_RS10340	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C3766_RS10345	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C3766_RS10350	COG0247	lactate metabolic process
C3766_RS10355	COG0277	FAD linked oxidase domain protein
C3766_RS10360	COG3835	regulator
C3766_RS10365	COG2132	Multicopper oxidase
C3766_RS10370	COG0071	Belongs to the small heat shock protein (HSP20) family
C3766_RS10375	COG2210	Belongs to the sulfur carrier protein TusA family
C3766_RS10390	COG0446	pyridine nucleotide-disulphide oxidoreductase
C3766_RS10410	COG0071	Belongs to the small heat shock protein (HSP20) family
C3766_RS10440	COG1704	LemA family
C3766_RS10450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C3766_RS10470	COG1183	phosphatidylcholine synthase activity
C3766_RS10480	COG3634	alkyl hydroperoxide reductase activity
C3766_RS10485	COG0450	alkyl hydroperoxide reductase
C3766_RS10515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C3766_RS10520	COG0572	uridine kinase
C3766_RS10525	COG4122	O-methyltransferase activity
C3766_RS10530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C3766_RS10535	COG3906	Belongs to the UPF0473 family
C3766_RS10540	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C3766_RS10545	COG4472	Bacterial protein of unknown function (DUF965)
C3766_RS10550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C3766_RS10555	COG0628	permease
C3766_RS10585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C3766_RS10595	COG0482	sulfurtransferase activity
C3766_RS10600	COG1104	cysteine desulfurase activity
C3766_RS10605	COG1959	2 iron, 2 sulfur cluster binding
C3766_RS10620	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS10625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C3766_RS10630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C3766_RS10635	COG0385	Bile acid
C3766_RS10645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C3766_RS10650	COG0124	histidyl-tRNA synthetase
C3766_RS10655	COG4991	sh3 domain protein
C3766_RS10655	COG3103	Sh3 type 3 domain protein
C3766_RS10655	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3766_RS10660	COG2814	Major facilitator Superfamily
C3766_RS10665	COG1566	PFAM secretion protein HlyD family protein
C3766_RS10670	COG1846	Transcriptional regulator
C3766_RS10675	COG1490	D-aminoacyl-tRNA deacylase activity
C3766_RS10685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C3766_RS10690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C3766_RS10690	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C3766_RS10695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3766_RS10695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C3766_RS10705	COG2244	polysaccharide biosynthetic process
C3766_RS10710	COG2323	membrane
C3766_RS10720	COG1862	Preprotein translocase
C3766_RS10725	COG0343	queuine tRNA-ribosyltransferase activity
C3766_RS10730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C3766_RS10760	COG0217	transcriptional regulatory protein
C3766_RS10770	COG1388	LysM domain
C3766_RS10775	COG1827	regulation of RNA biosynthetic process
C3766_RS10780	COG0077	Prephenate dehydratase
C3766_RS10785	COG4492	Belongs to the UPF0735 family
C3766_RS10790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C3766_RS10795	COG3290	protein histidine kinase activity
C3766_RS10800	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C3766_RS10805	COG2868	ribosomal protein
C3766_RS10810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C3766_RS10815	COG1530	ribonuclease E activity
C3766_RS10820	COG1994	Peptidase M50
C3766_RS10830	COG2894	cell division
C3766_RS10835	COG0850	regulation of cytokinetic process
C3766_RS10845	COG1792	Involved in formation and maintenance of cell shape
C3766_RS10850	COG1077	Cell shape determining protein MreB Mrl
C3766_RS10855	COG2003	Belongs to the UPF0758 family
C3766_RS10875	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C3766_RS10900	COG1459	type II secretion system
C3766_RS10910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C3766_RS10945	COG0285	dihydrofolate synthase activity
C3766_RS10950	COG0525	valine-tRNA ligase activity
C3766_RS10960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C3766_RS10965	COG1388	LysM domain
C3766_RS10965	COG1388	LysM domain
C3766_RS10970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C3766_RS10975	COG0113	porphobilinogen synthase activity
C3766_RS10990	COG0181	hydroxymethylbilane synthase activity
C3766_RS10995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C3766_RS11010	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C3766_RS11015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C3766_RS11020	COG0470	DNA polymerase III
C3766_RS11020	COG1067	ATP-dependent peptidase activity
C3766_RS11030	COG0544	peptidyl-prolyl cis-trans isomerase activity
C3766_RS11035	COG0457	Tetratricopeptide repeat
C3766_RS11035	COG1477	protein flavinylation
C3766_RS11060	COG0622	Phosphoesterase
C3766_RS11065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C3766_RS11070	COG5401	PFAM Sporulation and spore germination
C3766_RS11080	COG5577	PFAM Coat F domain
C3766_RS11085	COG1063	alcohol dehydrogenase
C3766_RS11090	COG5577	PFAM Coat F domain
C3766_RS11105	COG1846	Transcriptional regulator
C3766_RS11135	COG2197	response regulator
C3766_RS11140	COG0824	Thioesterase
C3766_RS11145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C3766_RS11155	COG2009	succinate dehydrogenase
C3766_RS11160	COG1719	4-vinyl reductase, 4VR
C3766_RS11170	COG0322	excinuclease ABC activity
C3766_RS11175	COG3118	belongs to the thioredoxin family
C3766_RS11180	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C3766_RS11185	COG2086	electron transfer activity
C3766_RS11190	COG1024	Enoyl-CoA hydratase
C3766_RS11195	COG1309	transcriptional regulator
C3766_RS11200	COG0318	PFAM AMP-dependent synthetase and ligase
C3766_RS11205	COG1193	negative regulation of DNA recombination
C3766_RS11210	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C3766_RS11210	COG1796	DNA polymerase
C3766_RS11215	COG1286	toxin biosynthetic process
C3766_RS11220	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C3766_RS11230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3766_RS11230	COG0072	phenylalanine-tRNA ligase activity
C3766_RS11235	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C3766_RS11240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C3766_RS11275	COG2329	Antibiotic biosynthesis monooxygenase
C3766_RS11290	COG1695	Transcriptional regulator
C3766_RS11310	COG0431	NADPH-dependent FMN reductase
C3766_RS11340	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C3766_RS11350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C3766_RS11360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C3766_RS11370	COG1484	DNA-dependent DNA replication
C3766_RS11375	COG3611	Membrane attachment protein
C3766_RS11380	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C3766_RS11385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C3766_RS11390	COG0237	dephospho-CoA kinase activity
C3766_RS11395	COG1971	Probably functions as a manganese efflux pump
C3766_RS11400	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3766_RS11405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3766_RS11405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C3766_RS11410	COG0039	L-malate dehydrogenase activity
C3766_RS11415	COG0538	isocitrate dehydrogenase activity
C3766_RS11420	COG0372	Belongs to the citrate synthase family
C3766_RS11425	COG2707	UPF0756 membrane protein
C3766_RS11430	COG0628	permease
C3766_RS11440	COG0205	6-phosphofructokinase activity
C3766_RS11445	COG0825	malonyl-CoA metabolic process
C3766_RS11450	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C3766_RS11455	COG0281	malic enzyme
C3766_RS11460	COG0587	DNA-directed DNA polymerase activity
C3766_RS11475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C3766_RS11485	COG4109	DRTGG domain
C3766_RS11490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C3766_RS11505	COG0589	response to stress
C3766_RS11515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C3766_RS11520	COG0827	DNA restriction-modification system
C3766_RS11525	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C3766_RS11530	COG3874	Sporulation protein YtfJ
C3766_RS11540	COG1714	RDD family
C3766_RS11545	COG0616	signal peptide processing
C3766_RS11550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3766_RS11560	COG0301	tRNA thio-modification
C3766_RS11565	COG1104	cysteine desulfurase activity
C3766_RS11570	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C3766_RS11575	COG1309	transcriptional regulator
C3766_RS11580	COG1956	GAF domain-containing protein
C3766_RS11585	COG2203	Gaf domain
C3766_RS11585	COG2199	diguanylate cyclase activity
C3766_RS11590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C3766_RS11605	COG0506	proline dehydrogenase activity
C3766_RS11610	COG1012	belongs to the aldehyde dehydrogenase family
C3766_RS11615	COG3290	protein histidine kinase activity
C3766_RS11615	COG3829	transcription factor binding
C3766_RS11630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C3766_RS11640	COG3383	formate dehydrogenase (NAD+) activity
C3766_RS11645	COG2427	Protein of unknown function (DUF1641)
C3766_RS11650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C3766_RS11655	COG0315	cyclic pyranopterin monophosphate synthase activity
C3766_RS11660	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C3766_RS11665	COG0314	molybdopterin synthase activity
C3766_RS11670	COG1763	Mo-molybdopterin cofactor biosynthetic process
C3766_RS11675	COG0303	'Molybdopterin
C3766_RS11690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C3766_RS11695	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C3766_RS11700	COG4149	molybdate abc transporter
C3766_RS11710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3766_RS11715	COG0454	-acetyltransferase
C3766_RS11720	COG0517	IMP dehydrogenase activity
C3766_RS11725	COG0123	including yeast histone deacetylase and acetoin utilization protein
C3766_RS11735	COG1605	Chorismate mutase
C3766_RS11735	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C3766_RS11740	COG4980	gas vesicle protein
C3766_RS11750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C3766_RS11755	COG1674	ftsk spoiiie
C3766_RS11765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C3766_RS11770	COG4848	Belongs to the UPF0354 family
C3766_RS11775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3766_RS11780	COG2208	phosphoserine phosphatase activity
C3766_RS11785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C3766_RS11795	COG5002	protein histidine kinase activity
C3766_RS11795	COG0784	Response regulator, receiver
C3766_RS11820	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
C3766_RS11825	COG1363	Peptidase, m42
C3766_RS11830	COG5584	Small secreted protein
C3766_RS11835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C3766_RS11840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C3766_RS11850	COG0510	thiamine kinase activity
C3766_RS11875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C3766_RS11885	COG1349	DNA-binding transcription factor activity
C3766_RS11890	COG2244	polysaccharide biosynthetic process
C3766_RS11910	COG0495	leucyl-tRNA aminoacylation
C3766_RS11915	COG2814	Major facilitator Superfamily
C3766_RS11930	COG0275	rRNA processing
C3766_RS11945	COG2267	carboxylic ester hydrolase activity
C3766_RS11950	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C3766_RS11955	COG0367	asparagine synthase
C3766_RS11960	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C3766_RS11965	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C3766_RS11975	COG1506	peptidase
C3766_RS11980	COG0655	NAD(P)H dehydrogenase (quinone) activity
C3766_RS11990	COG1070	Carbohydrate kinase
C3766_RS12020	COG1116	anion transmembrane transporter activity
C3766_RS12025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3766_RS12040	COG0783	Belongs to the Dps family
C3766_RS12045	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C3766_RS12055	COG0803	Belongs to the bacterial solute-binding protein 9 family
C3766_RS12065	COG4948	Mandelate Racemase Muconate Lactonizing
C3766_RS12075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C3766_RS12080	COG0596	Alpha beta hydrolase
C3766_RS12085	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C3766_RS12090	COG1169	isochorismate synthase
C3766_RS12095	COG1575	Belongs to the MenA family. Type 1 subfamily
C3766_RS12225	COG0577	efflux transmembrane transporter activity
C3766_RS12225	COG1136	(ABC) transporter
C3766_RS12250	COG1285	pathogenesis
C3766_RS12265	COG2217	Heavy metal translocating P-type atpase
C3766_RS12270	COG2608	mercury ion transmembrane transporter activity
C3766_RS12305	COG1937	Protein conserved in bacteria
C3766_RS12310	COG1522	sequence-specific DNA binding
C3766_RS12335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3766_RS12360	COG5002	protein histidine kinase activity
C3766_RS12365	COG0745	RESPONSE REGULATOR receiver
C3766_RS12370	COG1388	LysM domain
C3766_RS12375	COG4221	oxidoreductase activity
C3766_RS12385	COG0726	polysaccharide deacetylase
C3766_RS12410	COG0425	Belongs to the sulfur carrier protein TusA family
C3766_RS12410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C3766_RS12415	COG1937	Protein conserved in bacteria
C3766_RS12420	COG1525	nuclease
C3766_RS12425	COG2190	(PTS) system
C3766_RS12450	COG0235	Class ii aldolase
C3766_RS12455	COG2160	L-arabinose isomerase activity
C3766_RS12460	COG1609	Transcriptional regulator
C3766_RS12485	COG4214	carbohydrate transport
C3766_RS12490	COG2160	L-arabinose isomerase activity
C3766_RS12500	COG1609	Transcriptional regulator
C3766_RS12505	COG0840	transmembrane signaling receptor activity
C3766_RS12520	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS12525	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C3766_RS12540	COG1012	belongs to the aldehyde dehydrogenase family
C3766_RS12560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C3766_RS12570	COG2155	Conserved Protein
C3766_RS12580	COG1098	S1 RNA binding domain
C3766_RS12600	COG0656	L-ascorbic acid biosynthetic process
C3766_RS12620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C3766_RS12645	COG2814	Major facilitator Superfamily
C3766_RS12650	COG2050	protein possibly involved in aromatic compounds catabolism
C3766_RS12670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C3766_RS12680	COG0697	spore germination
C3766_RS12690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C3766_RS12695	COG3584	3D domain protein
C3766_RS12705	COG1252	NADH dehydrogenase
C3766_RS12710	COG0492	ferredoxin-NADP+ reductase activity
C3766_RS12735	COG0316	Belongs to the HesB IscA family
C3766_RS12740	COG4837	Protein of unknown function (DUF1462)
C3766_RS12745	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C3766_RS12755	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C3766_RS12760	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C3766_RS12765	COG0647	UMP catabolic process
C3766_RS12770	COG2445	Protein of unknown function DUF86
C3766_RS12775	COG4470	Protein conserved in bacteria
C3766_RS12780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C3766_RS12785	COG0739	heme binding
C3766_RS12795	COG3377	Domain of unknown function (DUF1805)
C3766_RS12800	COG0737	Belongs to the 5'-nucleotidase family
C3766_RS12805	COG0719	Fe-S assembly protein
C3766_RS12810	COG0822	iron-sulfur transferase activity
C3766_RS12815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C3766_RS12820	COG0719	Fe-S assembly protein
C3766_RS12825	COG0396	ATPase activity
C3766_RS12840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3766_RS12845	COG0509	glycine decarboxylation via glycine cleavage system
C3766_RS12850	COG1393	Belongs to the ArsC family
C3766_RS12855	COG1960	acyl-CoA dehydrogenase activity
C3766_RS12860	COG0183	Belongs to the thiolase family
C3766_RS12865	COG1024	Enoyl-CoA hydratase
C3766_RS12865	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3766_RS12880	COG5577	PFAM Coat F domain
C3766_RS12885	COG0772	Belongs to the SEDS family
C3766_RS12890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C3766_RS12905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C3766_RS12925	COG0753	catalase activity
C3766_RS12930	COG0671	phosphoesterase, PA-phosphatase related
C3766_RS12940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3766_RS12960	COG1595	DNA-templated transcription, initiation
C3766_RS12965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C3766_RS12980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C3766_RS12990	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C3766_RS12995	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS13000	COG2211	Major facilitator Superfamily
C3766_RS13005	COG1904	glucuronate isomerase
C3766_RS13010	COG2721	sulfolactate sulfo-lyase activity
C3766_RS13015	COG0246	Mannitol dehydrogenase
C3766_RS13025	COG0800	Aldolase
C3766_RS13030	COG1414	Transcriptional regulator
C3766_RS13095	COG0557	exoribonuclease II activity
C3766_RS13105	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C3766_RS13110	COG0148	phosphopyruvate hydratase activity
C3766_RS13115	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C3766_RS13125	COG0126	phosphoglycerate kinase activity
C3766_RS13145	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C3766_RS13195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3766_RS13210	COG4608	Belongs to the ABC transporter superfamily
C3766_RS13215	COG0791	NLP P60 protein
C3766_RS13220	COG4166	transmembrane transport
C3766_RS13225	COG0444	Belongs to the ABC transporter superfamily
C3766_RS13230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C3766_RS13235	COG0601	transmembrane transport
C3766_RS13240	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C3766_RS13250	COG0598	Magnesium transport protein CorA
C3766_RS13265	COG2719	SpoVR family
C3766_RS13270	COG3594	Acyltransferase
C3766_RS13295	COG1392	Phosphate transport regulator
C3766_RS13300	COG0306	phosphate transporter
C3766_RS13315	COG2718	Belongs to the UPF0229 family
C3766_RS13325	COG2766	serine protein kinase
C3766_RS13340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C3766_RS13355	COG2095	MarC family integral membrane protein
C3766_RS13370	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C3766_RS13375	COG0596	Alpha beta hydrolase
C3766_RS13380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3766_RS13385	COG0765	amino acid transport
C3766_RS13390	COG1126	abc transporter atp-binding protein
C3766_RS13395	COG2116	formate transmembrane transporter activity
C3766_RS13405	COG1882	Formate acetyltransferase
C3766_RS13410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C3766_RS13415	COG0431	NADPH-dependent FMN reductase
C3766_RS13430	COG1131	(ABC) transporter
C3766_RS13465	COG0745	RESPONSE REGULATOR receiver
C3766_RS13480	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C3766_RS13490	COG2188	Transcriptional regulator
C3766_RS13495	COG3104	oligopeptide transport
C3766_RS13500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3766_RS13505	COG1131	(ABC) transporter
C3766_RS13510	COG4555	ABC transporter
C3766_RS13550	COG0577	efflux transmembrane transporter activity
C3766_RS13550	COG1136	(ABC) transporter
C3766_RS13575	COG2271	Major facilitator Superfamily
C3766_RS13585	COG0697	spore germination
C3766_RS13600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3766_RS13710	COG3527	Alpha-acetolactate decarboxylase
C3766_RS13715	COG0028	Belongs to the TPP enzyme family
C3766_RS13720	COG0583	DNA-binding transcription factor activity
C3766_RS13725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C3766_RS13730	COG0549	Belongs to the carbamate kinase family
C3766_RS13740	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C3766_RS13750	COG0735	belongs to the Fur family
C3766_RS13765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C3766_RS13770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3766_RS13775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3766_RS13780	COG1116	anion transmembrane transporter activity
C3766_RS13790	COG2814	Major facilitator Superfamily
C3766_RS13810	COG1737	Transcriptional regulator
C3766_RS13815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3766_RS13815	COG1263	PTS System
C3766_RS13820	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C3766_RS13835	COG3557	Belongs to the UPF0374 family
C3766_RS13850	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS13855	COG0583	DNA-binding transcription factor activity
C3766_RS13860	COG0070	glutamate synthase
C3766_RS13860	COG0069	glutamate synthase activity
C3766_RS13860	COG0067	glutamate synthase
C3766_RS13865	COG0493	'glutamate synthase
C3766_RS13880	COG1131	(ABC) transporter
C3766_RS13895	COG1988	membrane-bound metal-dependent
C3766_RS13900	COG1194	a g-specific adenine glycosylase
C3766_RS13935	COG0159	tryptophan synthase activity
C3766_RS13945	COG0133	tryptophan synthase activity
C3766_RS13950	COG0134	indole-3-glycerol-phosphate synthase activity
C3766_RS13955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3766_RS13960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C3766_RS13960	COG0512	Glutamine amidotransferase of anthranilate synthase
C3766_RS13970	COG0577	efflux transmembrane transporter activity
C3766_RS13975	COG0577	efflux transmembrane transporter activity
C3766_RS13975	COG1136	(ABC) transporter
C3766_RS13980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C3766_RS14000	COG1131	(ABC) transporter
C3766_RS14040	COG2197	response regulator
C3766_RS14045	COG4585	Histidine kinase
C3766_RS14055	COG1012	belongs to the aldehyde dehydrogenase family
C3766_RS14055	COG1012	belongs to the aldehyde dehydrogenase family
C3766_RS14065	COG0058	SHG alpha-glucan phosphorylase activity
C3766_RS14070	COG0840	transmembrane signaling receptor activity
C3766_RS14075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3766_RS14080	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C3766_RS14085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C3766_RS14100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C3766_RS14105	COG0066	3-isopropylmalate dehydratase activity
C3766_RS14110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C3766_RS14120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3766_RS14125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C3766_RS14130	COG0440	acetolactate synthase activity
C3766_RS14135	COG0028	Belongs to the TPP enzyme family
C3766_RS14140	COG0129	dihydroxy-acid dehydratase activity
C3766_RS14150	COG1114	Component of the transport system for branched-chain amino acids
C3766_RS14160	COG1366	Belongs to the anti-sigma-factor antagonist family
C3766_RS14170	COG2124	cytochrome p450
C3766_RS14175	COG0670	Belongs to the BI1 family
C3766_RS14180	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3766_RS14185	COG2223	nitrite transmembrane transporter activity
C3766_RS14190	COG3279	Response regulator of the LytR AlgR family
C3766_RS14195	COG3275	phosphorelay sensor kinase activity
C3766_RS14200	COG0252	asparaginase activity
C3766_RS14205	COG2132	Multicopper oxidase
C3766_RS14210	COG1309	transcriptional regulator
C3766_RS14215	COG1511	domain protein
C3766_RS14250	COG0840	transmembrane signaling receptor activity
C3766_RS14250	COG5278	phosphoserine phosphatase activity
C3766_RS14255	COG3739	integral membrane protein
C3766_RS14260	COG3655	Transcriptional regulator
C3766_RS14275	COG1823	symporter activity
C3766_RS14280	COG2839	Protein conserved in bacteria
C3766_RS14300	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
C3766_RS14305	COG0477	Major facilitator Superfamily
C3766_RS14315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C3766_RS14320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C3766_RS14325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C3766_RS14330	COG0840	transmembrane signaling receptor activity
C3766_RS14350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C3766_RS14355	COG1132	(ABC) transporter
C3766_RS14360	COG1846	Transcriptional regulator
C3766_RS14370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C3766_RS14375	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C3766_RS14395	COG0387	Pfam Sodium calcium exchanger
C3766_RS14400	COG0477	Major facilitator Superfamily
C3766_RS14405	COG1295	ribonuclease BN
C3766_RS14410	COG4840	Belongs to the UPF0435 family
C3766_RS14415	COG0024	Methionine aminopeptidase
C3766_RS14420	COG0693	protein deglycase activity
C3766_RS14425	COG1360	Flagellar Motor Protein
C3766_RS14430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C3766_RS14440	COG3189	MarR family transcriptional regulator
C3766_RS14450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C3766_RS14455	COG1607	acyl-coa hydrolase
C3766_RS14460	COG1077	Cell shape determining protein MreB Mrl
C3766_RS14465	COG2268	Band 7 protein
C3766_RS14470	COG1585	Membrane protein implicated in regulation of membrane protease activity
C3766_RS14475	COG0626	cystathionine gamma-synthase activity
C3766_RS14480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C3766_RS14485	COG1854	S-ribosylhomocysteine lyase activity
C3766_RS14490	COG2226	methyltransferase
C3766_RS14495	COG0288	reversible hydration of carbon dioxide
C3766_RS14500	COG0860	N-Acetylmuramoyl-L-alanine amidase
C3766_RS14510	COG2197	response regulator
C3766_RS14540	COG4086	secreted protein
C3766_RS14545	COG0737	Belongs to the 5'-nucleotidase family
C3766_RS14560	COG3620	sequence-specific DNA binding
C3766_RS14565	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C3766_RS14570	COG1518	maintenance of DNA repeat elements
C3766_RS14630	COG1304	FMN binding
C3766_RS14635	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C3766_RS14640	COG0166	Belongs to the GPI family
C3766_RS14645	COG0025	NhaP-type Na H and K H
C3766_RS14650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3766_RS14650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C3766_RS14650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C3766_RS14655	COG1349	DNA-binding transcription factor activity
C3766_RS14660	COG0371	Dehydrogenase
C3766_RS14675	COG0561	phosphatase activity
C3766_RS14690	COG2814	Major facilitator Superfamily
C3766_RS14695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C3766_RS14710	COG2357	RelA SpoT domain protein
C3766_RS14715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C3766_RS14725	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C3766_RS14730	COG1461	Dihydroxyacetone kinase
C3766_RS14735	COG2376	Dihydroxyacetone kinase
C3766_RS14750	COG0778	Nitroreductase
C3766_RS14755	COG1113	amino acid transport
C3766_RS14760	COG0730	response to heat
C3766_RS14770	COG2233	PERMEase
C3766_RS14785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C3766_RS14810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C3766_RS14815	COG1024	Enoyl-CoA hydratase
C3766_RS14825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C3766_RS14830	COG0511	ligase activity, forming carbon-carbon bonds
C3766_RS14835	COG0439	Biotin carboxylase
C3766_RS14840	COG1960	acyl-CoA dehydrogenase activity
C3766_RS14845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C3766_RS14860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C3766_RS14865	COG3829	transcription factor binding
C3766_RS14885	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C3766_RS14895	COG0833	amino acid
C3766_RS14900	COG1309	transcriptional regulator
C3766_RS14955	COG3588	fructose-bisphosphate aldolase
C3766_RS14975	COG2986	histidine ammonia-lyase
C3766_RS14980	COG1116	anion transmembrane transporter activity
C3766_RS14985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3766_RS14995	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C3766_RS15000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3766_RS15005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C3766_RS15020	COG0402	S-adenosylhomocysteine deaminase activity
C3766_RS15040	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3766_RS15070	COG4268	DNA restriction-modification system
C3766_RS15075	COG1401	restriction endodeoxyribonuclease activity
C3766_RS15080	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C3766_RS15105	COG1280	lysine exporter protein (LysE YggA)
C3766_RS15110	COG0386	Belongs to the glutathione peroxidase family
C3766_RS15115	COG2190	(PTS) system
C3766_RS15140	COG1619	proteins homologs of microcin C7 resistance protein MccF
C3766_RS15155	COG1301	dicarboxylic acid transport
C3766_RS15165	COG3403	YqcI/YcgG family
C3766_RS15170	COG0582	viral genome integration into host DNA
C3766_RS15205	COG1328	CTP reductase activity
C3766_RS15215	COG1063	alcohol dehydrogenase
C3766_RS15225	COG1929	Belongs to the glycerate kinase type-1 family
C3766_RS15230	COG2610	gluconate transmembrane transporter activity
C3766_RS15235	COG1879	ABC-type sugar transport system periplasmic component
C3766_RS15240	COG1172	Belongs to the binding-protein-dependent transport system permease family
C3766_RS15245	COG1129	ABC transporter
C3766_RS15250	COG1869	D-ribose catabolic process
C3766_RS15255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C3766_RS15260	COG1609	Transcriptional regulator
C3766_RS15300	COG4549	nuclear export factor GLE1
C3766_RS15305	COG2372	response to copper ion
C3766_RS15305	COG1276	copper resistance
C3766_RS15315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C3766_RS15320	COG1609	Transcriptional regulator
C3766_RS15335	COG5002	protein histidine kinase activity
C3766_RS15340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C3766_RS15345	COG1278	Cold shock
C3766_RS15350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C3766_RS15355	COG0697	spore germination
C3766_RS15370	COG0697	spore germination
C3766_RS15375	COG1472	Belongs to the glycosyl hydrolase 3 family
C3766_RS15385	COG3876	Protein conserved in bacteria
C3766_RS15400	COG1132	(ABC) transporter
C3766_RS15405	COG1132	(ABC) transporter
C3766_RS15425	COG1388	LysM domain
C3766_RS15425	COG0791	NLP P60 protein
C3766_RS15445	COG2272	Belongs to the type-B carboxylesterase lipase family
C3766_RS15450	COG0154	amidase activity
C3766_RS15455	COG2814	Major facilitator Superfamily
C3766_RS15460	COG1012	belongs to the aldehyde dehydrogenase family
C3766_RS15500	COG3153	acetyltransferase
C3766_RS15500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C3766_RS15505	COG5583	Uncharacterized small protein (DUF2292)
C3766_RS15510	COG0431	NADPH-dependent FMN reductase
C3766_RS15515	COG1116	anion transmembrane transporter activity
C3766_RS15520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C3766_RS15525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C3766_RS15530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C3766_RS15555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C3766_RS15570	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C3766_RS15580	COG2390	Transcriptional regulator
C3766_RS15590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C3766_RS15600	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C3766_RS15615	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C3766_RS15620	COG1984	allophanate hydrolase subunit 2
C3766_RS15625	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C3766_RS15630	COG2814	Major facilitator Superfamily
C3766_RS15635	COG1764	response to oxidative stress
C3766_RS15640	COG1126	abc transporter atp-binding protein
C3766_RS15645	COG0765	amino acid transport
C3766_RS15650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3766_RS15660	COG0626	cystathionine gamma-synthase activity
C3766_RS15680	COG0800	Aldolase
C3766_RS15705	COG0326	Molecular chaperone. Has ATPase activity
C3766_RS15720	COG3335	DDE superfamily endonuclease
C3766_RS15730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C3766_RS15745	COG1064	alcohol dehydrogenase
C3766_RS15775	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS15810	COG3716	PTS system mannose fructose sorbose family IID component
C3766_RS15885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C3766_RS15890	COG1597	lipid kinase activity
C3766_RS15920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3766_RS15925	COG0154	amidase activity
C3766_RS15930	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C3766_RS15935	COG2224	Isocitrate lyase
C3766_RS15940	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C3766_RS15945	COG4851	CamS sex pheromone cAM373 precursor
C3766_RS15955	COG0210	DNA helicase
C3766_RS15960	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C3766_RS15965	COG4496	protein, YerC YecD
C3766_RS15970	COG1470	cell adhesion involved in biofilm formation
C3766_RS15985	COG0151	Belongs to the GarS family
C3766_RS15995	COG0138	bifunctional purine biosynthesis protein purh
C3766_RS16000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C3766_RS16005	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C3766_RS16010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C3766_RS16015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3766_RS16020	COG0047	phosphoribosylformylglycinamidine synthase activity
C3766_RS16025	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C3766_RS16035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C3766_RS16040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C3766_RS16045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C3766_RS16055	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C3766_RS16060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C3766_RS16065	COG2190	(PTS) system
C3766_RS16065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3766_RS16065	COG1263	PTS System
C3766_RS16080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C3766_RS16080	COG1263	PTS System
C3766_RS16105	COG1301	dicarboxylic acid transport
C3766_RS16115	COG3711	transcriptional antiterminator
C3766_RS16120	COG2252	PERMEase
C3766_RS16130	COG1132	(ABC) transporter
C3766_RS16135	COG2814	Major facilitator Superfamily
C3766_RS16140	COG2197	response regulator
C3766_RS16145	COG3850	Histidine kinase
C3766_RS16150	COG1131	(ABC) transporter
C3766_RS16160	COG0842	Transport permease protein
C3766_RS16175	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3766_RS16195	COG0824	Thioesterase
C3766_RS16200	COG0318	PFAM AMP-dependent synthetase and ligase
C3766_RS16205	COG0183	Belongs to the thiolase family
C3766_RS16210	COG1024	Enoyl-CoA hydratase
C3766_RS16215	COG1250	3-hydroxyacyl-CoA dehydrogenase
C3766_RS16225	COG2814	Major facilitator Superfamily
C3766_RS16235	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3766_RS16245	COG0471	metal ion transport
C3766_RS16275	COG1131	(ABC) transporter
C3766_RS16280	COG1725	Transcriptional regulator
C3766_RS16285	COG1695	Transcriptional regulator
C3766_RS16290	COG3479	Phenolic acid decarboxylase
C3766_RS16295	COG2910	NAD(P)H-binding
C3766_RS16300	COG1959	2 iron, 2 sulfur cluster binding
C3766_RS16340	COG0425	Belongs to the sulfur carrier protein TusA family
C3766_RS16345	COG2391	methyltransferase activity
C3766_RS16355	COG1028	Short-chain dehydrogenase reductase Sdr
C3766_RS16375	COG1120	ATPase activity
C3766_RS16380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C3766_RS16415	COG3620	sequence-specific DNA binding
C3766_RS16430	COG0519	Catalyzes the synthesis of GMP from XMP
C3766_RS16430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C3766_RS16435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C3766_RS16440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C3766_RS16445	COG1335	isochorismatase
C3766_RS16450	COG4948	Mandelate Racemase Muconate Lactonizing
C3766_RS16460	COG0463	Glycosyl transferase, family 2
C3766_RS16465	COG2246	polysaccharide biosynthetic process
C3766_RS16470	COG0459	protein refolding
C3766_RS16475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C3766_RS16480	COG1266	CAAX protease self-immunity
C3766_RS16490	COG0805	protein transport
C3766_RS16495	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C3766_RS16500	COG0488	(ABC) transporter
C3766_RS16515	COG0456	acetyltransferase
C3766_RS16520	COG1214	PFAM Peptidase M22, glycoprotease
C3766_RS16525	COG0802	atpase or kinase
C3766_RS16610	COG3091	SprT-like family
C3766_RS16620	COG2183	response to ionizing radiation
C3766_RS16625	COG2208	phosphoserine phosphatase activity
C3766_RS16630	COG1191	sigma factor activity
C3766_RS16635	COG2172	sigma factor antagonist activity
C3766_RS16640	COG1366	Belongs to the anti-sigma-factor antagonist family
C3766_RS16645	COG2208	phosphoserine phosphatase activity
C3766_RS16650	COG2172	sigma factor antagonist activity
C3766_RS16655	COG1366	Belongs to the anti-sigma-factor antagonist family
C3766_RS16660	COG1366	Belongs to the anti-sigma-factor antagonist family
C3766_RS16670	COG2337	Toxic component of a toxin-antitoxin (TA) module
C3766_RS16675	COG0864	Transcriptional regulator
C3766_RS16685	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C3766_RS16690	COG0736	holo-[acyl-carrier-protein] synthase activity
C3766_RS16695	COG0705	Rhomboid family
C3766_RS16700	COG0513	Belongs to the DEAD box helicase family
C3766_RS16725	COG1280	lysine exporter protein (LysE YggA)
C3766_RS16735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C3766_RS16740	COG1609	Transcriptional regulator
C3766_RS16745	COG0366	Alpha amylase catalytic
C3766_RS16755	COG2182	Extracellular solute-binding protein
C3766_RS16760	COG1175	transmembrane transport
C3766_RS16765	COG3833	ABC-type maltose transport systems, permease component
C3766_RS16770	COG5521	maltodextrose utilization protein MalA
C3766_RS16775	COG1554	hydrolase, family 65, central catalytic
C3766_RS16785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C3766_RS16790	COG1181	Belongs to the D-alanine--D-alanine ligase family
C3766_RS16805	COG1253	flavin adenine dinucleotide binding
C3766_RS16810	COG0789	Transcriptional regulator
C3766_RS16815	COG1253	flavin adenine dinucleotide binding
C3766_RS16830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C3766_RS16845	COG0629	single-stranded DNA binding
C3766_RS16850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C3766_RS16855	COG4786	Flagellar basal body rod
C3766_RS16860	COG4786	Flagellar basal body rod
C3766_RS16870	COG1609	Transcriptional regulator
C3766_RS16875	COG0739	heme binding
C3766_RS16880	COG2385	sporulation resulting in formation of a cellular spore
C3766_RS16890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3766_RS16900	COG4836	Membrane
C3766_RS16905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C3766_RS16910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C3766_RS16915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C3766_RS16920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C3766_RS16925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3766_RS16935	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C3766_RS16940	COG0356	it plays a direct role in the translocation of protons across the membrane
C3766_RS16950	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C3766_RS16960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C3766_RS16970	COG0698	ribose 5-phosphate isomerase
C3766_RS16990	COG1971	Probably functions as a manganese efflux pump
C3766_RS16995	COG0009	L-threonylcarbamoyladenylate synthase
C3766_RS17010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C3766_RS17020	COG1435	thymidine kinase activity
C3766_RS17025	COG0254	rRNA binding
C3766_RS17035	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C3766_RS17040	COG1494	fructose-1,6-bisphosphatase
C3766_RS17045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C3766_RS17050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C3766_RS17055	COG0191	fructose-bisphosphate aldolase activity
C3766_RS17060	COG2204	response regulator
C3766_RS17075	COG1131	(ABC) transporter
C3766_RS17080	COG1725	Transcriptional regulator
C3766_RS17085	COG0504	CTP synthase activity
C3766_RS17090	COG3343	RNA polymerase activity
C3766_RS17110	COG1136	(ABC) transporter
C3766_RS17135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3766_RS17135	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C3766_RS17135	COG1703	isobutyryl-CoA mutase activity
C3766_RS17140	COG1309	transcriptional regulator
C3766_RS17145	COG1960	acyl-CoA dehydrogenase activity
C3766_RS17150	COG1960	acyl-CoA dehydrogenase activity
C3766_RS17155	COG0183	Belongs to the thiolase family
C3766_RS17160	COG0247	lactate metabolic process
C3766_RS17160	COG2181	nitrate reductase activity
C3766_RS17165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C3766_RS17170	COG0018	arginyl-trna synthetase
C3766_RS17180	COG0010	Belongs to the arginase family
C3766_RS17185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C3766_RS17195	COG1994	Peptidase M50
C3766_RS17205	COG3465	dGTPase activity
C3766_RS17210	COG1078	dGTPase activity
C3766_RS17225	COG0280	phosphate acetyltransferase
C3766_RS17230	COG3253	May function as heme-dependent peroxidase
C3766_RS17240	COG2363	Small membrane protein
C3766_RS17250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C3766_RS17280	COG4555	ABC transporter
C3766_RS17295	COG1122	ATPase activity
C3766_RS17320	COG0351	phosphomethylpyrimidine kinase
C3766_RS17335	COG0561	phosphatase activity
C3766_RS17340	COG0514	ATP-dependent DNA helicase (RecQ)
C3766_RS17345	COG1785	Belongs to the alkaline phosphatase family
C3766_RS17350	COG1737	Transcriptional regulator
C3766_RS17360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C3766_RS17365	COG1346	cytolysis
C3766_RS17370	COG1380	Effector of murein hydrolase LrgA
C3766_RS17375	COG0583	DNA-binding transcription factor activity
C3766_RS17380	COG0367	asparagine synthase
C3766_RS17405	COG2966	Psort location CytoplasmicMembrane, score
C3766_RS17410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C3766_RS17415	COG1966	Carbon starvation protein
C3766_RS17430	COG1464	Belongs to the NlpA lipoprotein family
C3766_RS17435	COG2011	ABC-type metal ion transport system permease component
C3766_RS17440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C3766_RS17445	COG1119	ATPase activity
C3766_RS17460	COG0534	Mate efflux family protein
C3766_RS17465	COG1442	glycosyl transferase family 8
C3766_RS17470	COG2195	Cleaves the N-terminal amino acid of tripeptides
C3766_RS17475	COG2814	Major facilitator Superfamily
C3766_RS17495	COG0028	Belongs to the TPP enzyme family
C3766_RS17500	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C3766_RS17505	COG1132	(ABC) transporter
C3766_RS17515	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C3766_RS17535	COG2188	Transcriptional regulator
C3766_RS17540	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C3766_RS17545	COG1366	Belongs to the anti-sigma-factor antagonist family
C3766_RS17550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C3766_RS17555	COG0765	amino acid transport
C3766_RS17560	COG1126	abc transporter atp-binding protein
C3766_RS17585	COG3457	Alanine racemase
C3766_RS17595	COG1126	abc transporter atp-binding protein
C3766_RS17605	COG0765	amino acid transport
C3766_RS17615	COG0579	oxidoreductase
C3766_RS17620	COG0477	Major facilitator Superfamily
C3766_RS17660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C3766_RS17665	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C3766_RS17670	COG4863	YycH protein
C3766_RS17675	COG5002	protein histidine kinase activity
C3766_RS17680	COG0745	RESPONSE REGULATOR receiver
C3766_RS17700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C3766_RS17705	COG0305	Participates in initiation and elongation during chromosome replication
C3766_RS17710	COG0359	binds to the 23S rRNA
C3766_RS17715	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C3766_RS17725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C3766_RS17735	COG0360	Binds together with S18 to 16S ribosomal RNA
C3766_RS17740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C3766_RS17745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3766_RS17745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C3766_RS17750	COG0307	riboflavin synthase, alpha
C3766_RS17755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3766_RS17755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C3766_RS17760	COG0012	GTP binding
C3766_RS17765	COG4481	Protein conserved in bacteria
C3766_RS17770	COG0668	transmembrane transport
C3766_RS17785	COG1475	DNA binding
C3766_RS17790	COG1192	Involved in chromosome partitioning
C3766_RS17800	COG1475	DNA binding
C3766_RS17805	COG0357	Ribosomal RNA small subunit methyltransferase G
C3766_RS17810	COG0445	tRNA wobble uridine modification
C3766_RS17815	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C3766_RS17820	COG1847	R3H domain protein
C3766_RS17825	COG0706	membrane insertase activity
C3766_RS17830	COG0594	ribonuclease P activity
C3766_RS17835	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C3766_RS18040	COG0179	Fumarylacetoacetate (FAA) hydrolase
C3766_RS18085	COG3829	transcription factor binding