locus-tag	class	description
OF158_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OF158_RS00010	COG0592	DNA-directed DNA polymerase activity
OF158_RS00015	COG2501	S4 domain
OF158_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OF158_RS00030	COG0187	DNA topoisomerase II activity
OF158_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OF158_RS00040	COG3437	response regulator, receiver
OF158_RS00075	COG1982	Orn Lys Arg decarboxylase major
OF158_RS00085	COG3870	Protein conserved in bacteria
OF158_RS00090	COG1728	Protein conserved in bacteria
OF158_RS00095	COG0470	DNA polymerase III
OF158_RS00100	COG1774	PSP1 C-terminal conserved region
OF158_RS00105	COG4467	Involved in initiation control of chromosome replication
OF158_RS00110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
OF158_RS00120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
OF158_RS00125	COG2002	toxin-antitoxin pair type II binding
OF158_RS00135	COG0084	hydrolase, TatD family'
OF158_RS00145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OF158_RS00155	COG4466	Protein conserved in bacteria
OF158_RS00165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OF158_RS00170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OF158_RS00175	COG0251	oxidation-reduction process
OF158_RS00200	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OF158_RS00205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OF158_RS00210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
OF158_RS00215	COG0193	aminoacyl-tRNA hydrolase activity
OF158_RS00225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OF158_RS00230	COG2002	toxin-antitoxin pair type II binding
OF158_RS00235	COG2244	polysaccharide biosynthetic process
OF158_RS00240	COG3956	TIGRFAM MazG family protein
OF158_RS00245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OF158_RS00265	COG1098	S1 RNA binding domain
OF158_RS00275	COG2208	phosphoserine phosphatase activity
OF158_RS00280	COG2304	oxidoreductase activity
OF158_RS00285	COG0515	serine threonine protein kinase
OF158_RS00290	COG0037	tRNA processing
OF158_RS00295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
OF158_RS00300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OF158_RS00305	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
OF158_RS00310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OF158_RS00315	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OF158_RS00320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OF158_RS00325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OF158_RS00330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OF158_RS00360	COG0516	GMP reductase activity
OF158_RS00360	COG0517	IMP dehydrogenase activity
OF158_RS00375	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
OF158_RS00380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OF158_RS00390	COG1428	Deoxynucleoside kinase
OF158_RS00395	COG1428	Deoxynucleoside kinase
OF158_RS00400	COG1388	LysM domain
OF158_RS00400	COG3858	chitin binding
OF158_RS00415	COG0590	tRNA wobble adenosine to inosine editing
OF158_RS00425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OF158_RS00430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OF158_RS00435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OF158_RS00485	COG3880	PFAM UvrB UvrC protein
OF158_RS00490	COG3869	Catalyzes the specific phosphorylation of arginine residues in
OF158_RS00495	COG0542	response to heat
OF158_RS00500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
OF158_RS00505	COG4956	integral membrane protein (PIN domain superfamily)
OF158_RS00515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OF158_RS00520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OF158_RS00525	COG1045	serine acetyltransferase
OF158_RS00530	COG0215	cysteine-tRNA ligase activity
OF158_RS00540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OF158_RS00545	COG3688	RNA-binding protein containing a PIN domain
OF158_RS00555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OF158_RS00560	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OF158_RS00565	COG0250	Participates in transcription elongation, termination and antitermination
OF158_RS00570	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OF158_RS00575	COG0081	regulation of translation
OF158_RS00580	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OF158_RS00585	COG0222	ribosome binding
OF158_RS00590	COG2813	Specifically methylates the guanine in position
OF158_RS00605	COG1358	cellular component organization or biogenesis
OF158_RS00610	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OF158_RS00615	COG0049	tRNA binding
OF158_RS00620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OF158_RS00625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OF158_RS00630	COG0051	transcription antitermination factor activity, RNA binding
OF158_RS00640	COG0088	Forms part of the polypeptide exit tunnel
OF158_RS00645	COG0089	rRNA binding
OF158_RS00650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OF158_RS00655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OF158_RS00665	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OF158_RS00670	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OF158_RS00675	COG0255	Belongs to the universal ribosomal protein uL29 family
OF158_RS00680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OF158_RS00685	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OF158_RS00690	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OF158_RS00700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OF158_RS00705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OF158_RS00710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OF158_RS00715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OF158_RS00720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OF158_RS00730	COG0200	Binds to the 23S rRNA
OF158_RS00735	COG0201	protein transport
OF158_RS00740	COG0563	adenylate kinase activity
OF158_RS00745	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OF158_RS00750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OF158_RS00755	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OF158_RS00760	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OF158_RS00765	COG0202	RNA polymerase activity
OF158_RS00770	COG0203	ribosomal protein L17
OF158_RS00775	COG1122	ATPase activity
OF158_RS00780	COG1122	ATPase activity
OF158_RS00785	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
OF158_RS00795	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OF158_RS00800	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OF158_RS00815	COG2046	Belongs to the sulfate adenylyltransferase family
OF158_RS00820	COG0529	Catalyzes the synthesis of activated sulfate
OF158_RS00825	COG0833	amino acid
OF158_RS00835	COG0860	N-Acetylmuramoyl-L-alanine amidase
OF158_RS00840	COG0489	protein tyrosine kinase activity
OF158_RS00850	COG2194	sulfuric ester hydrolase activity
OF158_RS00860	COG0726	polysaccharide deacetylase
OF158_RS00870	COG1271	oxidase subunit
OF158_RS00875	COG1294	oxidase, subunit
OF158_RS00880	COG4988	ABC transporter
OF158_RS00885	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
OF158_RS00890	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS00965	COG1525	nuclease
OF158_RS00990	COG3620	sequence-specific DNA binding
OF158_RS01125	COG1388	LysM domain
OF158_RS01125	COG3942	CHAP domain
OF158_RS01135	COG1525	nuclease
OF158_RS01160	COG3620	sequence-specific DNA binding
OF158_RS01210	COG5377	YqaJ viral recombinase family
OF158_RS01215	COG3723	Recombinational DNA repair protein, rece pathway
OF158_RS01410	COG1388	LysM domain
OF158_RS01410	COG3942	CHAP domain
OF158_RS01425	COG1595	DNA-templated transcription, initiation
OF158_RS01430	COG5662	AntiSigma factor
OF158_RS01435	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
OF158_RS01440	COG4856	YbbR-like protein
OF158_RS01445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OF158_RS01450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OF158_RS01520	COG2814	Major facilitator Superfamily
OF158_RS01525	COG0583	DNA-binding transcription factor activity
OF158_RS01535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OF158_RS01540	COG0840	transmembrane signaling receptor activity
OF158_RS01555	COG1695	Transcriptional regulator
OF158_RS01560	COG0840	transmembrane signaling receptor activity
OF158_RS01565	COG0477	Major facilitator Superfamily
OF158_RS01600	COG1181	Belongs to the D-alanine--D-alanine ligase family
OF158_RS01630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OF158_RS01635	COG2814	Major facilitator Superfamily
OF158_RS01645	COG0519	Catalyzes the synthesis of GMP from XMP
OF158_RS01665	COG0477	Major facilitator Superfamily
OF158_RS01665	COG2814	Major facilitator Superfamily
OF158_RS01720	COG3425	synthase
OF158_RS01730	COG0183	Belongs to the thiolase family
OF158_RS01755	COG0517	IMP dehydrogenase activity
OF158_RS01755	COG1125	glycine betaine transport
OF158_RS01760	COG1174	glycine betaine transport
OF158_RS01765	COG2190	(PTS) system
OF158_RS01770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OF158_RS01770	COG1263	PTS System
OF158_RS01775	COG0366	Alpha amylase catalytic
OF158_RS01780	COG2188	Transcriptional regulator
OF158_RS01790	COG1070	Carbohydrate kinase
OF158_RS01800	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
OF158_RS01805	COG0716	FMN binding
OF158_RS01820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OF158_RS01830	COG2217	Heavy metal translocating P-type atpase
OF158_RS01840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OF158_RS01850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OF158_RS01855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OF158_RS01860	COG0463	Glycosyl transferase, family 2
OF158_RS01890	COG2076	Multidrug Resistance protein
OF158_RS01895	COG2076	Multidrug Resistance protein
OF158_RS01905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OF158_RS01910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OF158_RS01915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OF158_RS01920	COG1120	ATPase activity
OF158_RS01945	COG0217	transcriptional regulatory protein
OF158_RS01950	COG1366	Belongs to the anti-sigma-factor antagonist family
OF158_RS01960	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS01970	COG1309	transcriptional regulator
OF158_RS01985	COG1012	belongs to the aldehyde dehydrogenase family
OF158_RS01995	COG5434	Belongs to the glycosyl hydrolase 28 family
OF158_RS02005	COG0175	sulfate reduction
OF158_RS02025	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OF158_RS02035	COG0371	Dehydrogenase
OF158_RS02040	COG0318	PFAM AMP-dependent synthetase and ligase
OF158_RS02055	COG0697	spore germination
OF158_RS02075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OF158_RS02085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
OF158_RS02100	COG0702	epimerase
OF158_RS02120	COG2213	PTS system mannitol-specific
OF158_RS02120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF158_RS02125	COG3711	transcriptional antiterminator
OF158_RS02130	COG0246	Mannitol dehydrogenase
OF158_RS02135	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
OF158_RS02155	COG2848	UPF0210 protein
OF158_RS02160	COG1609	Transcriptional regulator
OF158_RS02170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OF158_RS02185	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OF158_RS02195	COG5577	PFAM Coat F domain
OF158_RS02200	COG0667	Aldo Keto reductase
OF158_RS02210	COG1113	amino acid transport
OF158_RS02220	COG3104	oligopeptide transport
OF158_RS02225	COG0833	amino acid
OF158_RS02235	COG3842	ATPase activity
OF158_RS02240	COG1176	ABC-type spermidine putrescine transport system, permease component I
OF158_RS02280	COG0531	amino acid
OF158_RS02285	COG1556	Lactate utilization protein
OF158_RS02290	COG1139	Iron-sulfur cluster binding protein
OF158_RS02295	COG0247	lactate metabolic process
OF158_RS02305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OF158_RS02310	COG1454	alcohol dehydrogenase
OF158_RS02320	COG1953	Uracil, thiamine, allantoin
OF158_RS02345	COG0531	amino acid
OF158_RS02350	COG1979	alcohol dehydrogenase
OF158_RS02355	COG0004	ammonium transporteR
OF158_RS02360	COG3290	protein histidine kinase activity
OF158_RS02365	COG4565	transcriptional regulatory protein
OF158_RS02370	COG2851	Citrate transporter
OF158_RS02375	COG0463	Glycosyl transferase, family 2
OF158_RS02380	COG3973	AAA domain
OF158_RS02390	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
OF158_RS02395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OF158_RS02400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OF158_RS02405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
OF158_RS02410	COG1301	dicarboxylic acid transport
OF158_RS02415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OF158_RS02435	COG1902	pentaerythritol trinitrate reductase activity
OF158_RS02455	COG0423	glycine-tRNA ligase activity
OF158_RS02460	COG0531	amino acid
OF158_RS02470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OF158_RS02475	COG0628	permease
OF158_RS02490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OF158_RS02495	COG0765	amino acid transport
OF158_RS02500	COG0765	amino acid transport
OF158_RS02515	COG1733	regulation of RNA biosynthetic process
OF158_RS02525	COG0586	Pfam SNARE associated Golgi protein
OF158_RS02530	COG0586	Pfam SNARE associated Golgi protein
OF158_RS02545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OF158_RS02545	COG0646	methionine synthase
OF158_RS02550	COG1410	methionine synthase
OF158_RS02550	COG0646	methionine synthase
OF158_RS02575	COG3944	biosynthesis protein
OF158_RS02580	COG0489	protein tyrosine kinase activity
OF158_RS02585	COG4464	protein tyrosine phosphatase activity
OF158_RS02590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OF158_RS02595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OF158_RS02630	COG0662	Cupin 2, conserved barrel domain protein
OF158_RS02630	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
OF158_RS02635	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
OF158_RS02655	COG1501	Belongs to the glycosyl hydrolase 31 family
OF158_RS02665	COG2115	Belongs to the xylose isomerase family
OF158_RS02670	COG1070	Carbohydrate kinase
OF158_RS02700	COG1070	Carbohydrate kinase
OF158_RS02710	COG1940	carbohydrate kinase activity
OF158_RS02715	COG1063	alcohol dehydrogenase
OF158_RS02720	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OF158_RS02725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OF158_RS02755	COG4193	domain, Protein
OF158_RS02775	COG5504	Zn-dependent protease
OF158_RS02780	COG2226	methyltransferase
OF158_RS02820	COG3716	PTS system mannose fructose sorbose family IID component
OF158_RS02825	COG3715	PTS system
OF158_RS02830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OF158_RS02835	COG0363	glucosamine-6-phosphate deaminase activity
OF158_RS02840	COG2188	Transcriptional regulator
OF158_RS02845	COG1396	sequence-specific DNA binding
OF158_RS02855	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
OF158_RS02860	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OF158_RS02865	COG3933	PFAM sigma-54 factor interaction domain-containing protein
OF158_RS02865	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
OF158_RS02875	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OF158_RS02875	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF158_RS02880	COG3715	PTS system
OF158_RS02885	COG3716	PTS system mannose fructose sorbose family IID component
OF158_RS02905	COG3414	Phosphotransferase system galactitol-specific IIB component
OF158_RS02910	COG3775	system Galactitol-specific IIC component
OF158_RS02920	COG1105	Belongs to the carbohydrate kinase PfkB family
OF158_RS02925	COG0235	Class ii aldolase
OF158_RS02945	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OF158_RS02955	COG0145	ligase activity
OF158_RS02965	COG2315	Protein conserved in bacteria
OF158_RS02975	COG2333	competence protein COMEC
OF158_RS02975	COG0658	competence protein
OF158_RS02985	COG3867	Arabinogalactan endo-beta-1,4-galactanase
OF158_RS03005	COG0531	amino acid
OF158_RS03010	COG1316	TRANSCRIPTIONal
OF158_RS03020	COG4989	oxidoreductase activity
OF158_RS03050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
OF158_RS03055	COG2130	NADP-dependent
OF158_RS03065	COG3711	transcriptional antiterminator
OF158_RS03065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF158_RS03070	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OF158_RS03075	COG1447	Phosphotransferase system cellobiose-specific component IIA
OF158_RS03085	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OF158_RS03090	COG2211	Major facilitator Superfamily
OF158_RS03090	COG2190	(PTS) system
OF158_RS03100	COG1113	amino acid transport
OF158_RS03115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OF158_RS03125	COG2814	Major facilitator Superfamily
OF158_RS03130	COG1609	Transcriptional regulator
OF158_RS03140	COG1174	glycine betaine transport
OF158_RS03145	COG1732	Glycine betaine
OF158_RS03150	COG1174	glycine betaine transport
OF158_RS03155	COG1125	glycine betaine transport
OF158_RS03155	COG0517	IMP dehydrogenase activity
OF158_RS03160	COG1510	regulation of RNA biosynthetic process
OF158_RS03165	COG0110	maltose O-acetyltransferase activity
OF158_RS03170	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS03180	COG4297	protein containing double-stranded beta helix domain
OF158_RS03190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OF158_RS03200	COG2272	Belongs to the type-B carboxylesterase lipase family
OF158_RS03205	COG0606	chelatase, subunit chli
OF158_RS03220	COG0371	Dehydrogenase
OF158_RS03225	COG2814	Major facilitator Superfamily
OF158_RS03230	COG1070	Carbohydrate kinase
OF158_RS03235	COG2115	Belongs to the xylose isomerase family
OF158_RS03250	COG0157	Belongs to the NadC ModD family
OF158_RS03255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
OF158_RS03260	COG1104	cysteine desulfurase activity
OF158_RS03270	COG2116	formate transmembrane transporter activity
OF158_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS03305	COG2610	gluconate transmembrane transporter activity
OF158_RS03310	COG1012	belongs to the aldehyde dehydrogenase family
OF158_RS03320	COG3290	protein histidine kinase activity
OF158_RS03320	COG3829	transcription factor binding
OF158_RS03325	COG1501	Belongs to the glycosyl hydrolase 31 family
OF158_RS03340	COG0318	PFAM AMP-dependent synthetase and ligase
OF158_RS03350	COG1309	transcriptional regulator
OF158_RS03365	COG1363	Peptidase, m42
OF158_RS03405	COG2972	Histidine kinase
OF158_RS03425	COG0531	amino acid
OF158_RS03435	COG1620	l-lactate permease
OF158_RS03440	COG2186	Transcriptional regulator
OF158_RS03495	COG1447	Phosphotransferase system cellobiose-specific component IIA
OF158_RS03510	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OF158_RS03510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OF158_RS03515	COG2723	6-phospho-beta-galactosidase activity
OF158_RS03520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF158_RS03520	COG3711	transcriptional antiterminator
OF158_RS03525	COG2877	3-deoxy-8-phosphooctulonate synthase activity
OF158_RS03535	COG1131	(ABC) transporter
OF158_RS03545	COG0626	cystathionine gamma-synthase activity
OF158_RS03550	COG0626	cystathionine gamma-synthase activity
OF158_RS03570	COG1653	transport
OF158_RS03575	COG2207	Transcriptional regulator
OF158_RS03590	COG0604	alcohol dehydrogenase
OF158_RS03595	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
OF158_RS03600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OF158_RS03620	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS03625	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OF158_RS03635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
OF158_RS03645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OF158_RS03650	COG1316	TRANSCRIPTIONal
OF158_RS03655	COG1136	(ABC) transporter
OF158_RS03655	COG0577	efflux transmembrane transporter activity
OF158_RS03670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
OF158_RS03685	COG1388	LysM domain
OF158_RS03685	COG3584	3D domain protein
OF158_RS03695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OF158_RS03705	COG0011	TIGRFAM Protein of
OF158_RS03710	COG2706	6-phosphogluconolactonase activity
OF158_RS03720	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
OF158_RS03720	COG3933	PFAM sigma-54 factor interaction domain-containing protein
OF158_RS03725	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OF158_RS03725	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF158_RS03735	COG3715	PTS system
OF158_RS03740	COG3716	PTS system mannose fructose sorbose family IID component
OF158_RS03755	COG2079	MmgE PrpD family protein
OF158_RS03760	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
OF158_RS03770	COG0154	amidase activity
OF158_RS03780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OF158_RS03785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OF158_RS03790	COG1116	anion transmembrane transporter activity
OF158_RS03795	COG0083	homoserine kinase activity
OF158_RS03800	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OF158_RS03805	COG0460	homoserine dehydrogenase
OF158_RS03810	COG0010	Belongs to the arginase family
OF158_RS03820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OF158_RS03825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OF158_RS03835	COG4145	pantothenate transmembrane transporter activity
OF158_RS03855	COG1012	belongs to the aldehyde dehydrogenase family
OF158_RS03855	COG1454	alcohol dehydrogenase
OF158_RS03870	COG0791	NLP P60 protein
OF158_RS03870	COG1388	LysM domain
OF158_RS03875	COG0024	Methionine aminopeptidase
OF158_RS03880	COG1268	BioY protein
OF158_RS03890	COG0318	PFAM AMP-dependent synthetase and ligase
OF158_RS03895	COG1960	acyl-CoA dehydrogenase activity
OF158_RS03900	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS03905	COG2746	aminoglycoside 3-N-acetyltransferase activity
OF158_RS03910	COG2244	polysaccharide biosynthetic process
OF158_RS03915	COG0589	response to stress
OF158_RS03930	COG0535	radical SAM domain protein
OF158_RS03935	COG0457	Tetratricopeptide repeat
OF158_RS03940	COG1063	alcohol dehydrogenase
OF158_RS03950	COG1609	Transcriptional regulator
OF158_RS03960	COG0561	phosphatase activity
OF158_RS03985	COG0656	L-ascorbic acid biosynthetic process
OF158_RS04000	COG0657	acetylesterase activity
OF158_RS04010	COG0656	L-ascorbic acid biosynthetic process
OF158_RS04015	COG0431	NADPH-dependent FMN reductase
OF158_RS04020	COG0420	3'-5' exonuclease activity
OF158_RS04025	COG4717	serine-type aminopeptidase activity
OF158_RS04030	COG1250	3-hydroxyacyl-CoA dehydrogenase
OF158_RS04035	COG0534	Mate efflux family protein
OF158_RS04040	COG1664	Polymer-forming cytoskeletal
OF158_RS04050	COG0789	Transcriptional regulator
OF158_RS04055	COG0436	Aminotransferase
OF158_RS04060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
OF158_RS04070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OF158_RS04080	COG2226	methyltransferase
OF158_RS04095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OF158_RS04145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OF158_RS04150	COG1113	amino acid transport
OF158_RS04155	COG2814	Major facilitator Superfamily
OF158_RS04165	COG2409	Drug exporters of the RND superfamily
OF158_RS04165	COG1033	growth of symbiont in host cell
OF158_RS04170	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
OF158_RS04185	COG1960	acyl-CoA dehydrogenase activity
OF158_RS04205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OF158_RS04210	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
OF158_RS04220	COG1609	Transcriptional regulator
OF158_RS04240	COG2996	Protein conserved in bacteria
OF158_RS04245	COG0346	lactoylglutathione lyase activity
OF158_RS04250	COG1482	cell wall glycoprotein biosynthetic process
OF158_RS04260	COG0477	Major facilitator Superfamily
OF158_RS04265	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OF158_RS04275	COG2188	Transcriptional regulator
OF158_RS04280	COG0791	NLP P60 protein
OF158_RS04280	COG1388	LysM domain
OF158_RS04290	COG0768	penicillin binding
OF158_RS04295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OF158_RS04300	COG1739	Uncharacterized protein family UPF0029
OF158_RS04325	COG0531	amino acid
OF158_RS04330	COG1307	EDD domain protein, DegV family
OF158_RS04335	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
OF158_RS04340	COG1040	competence protein
OF158_RS04350	COG2747	anti-sigma28 factor FlgM
OF158_RS04360	COG1256	bacterial-type flagellum assembly
OF158_RS04360	COG4786	Flagellar basal body rod
OF158_RS04365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
OF158_RS04375	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
OF158_RS04395	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
OF158_RS04400	COG1285	pathogenesis
OF158_RS04405	COG0647	UMP catabolic process
OF158_RS04415	COG2271	Major facilitator Superfamily
OF158_RS04420	COG1113	amino acid transport
OF158_RS04430	COG1113	amino acid transport
OF158_RS04435	COG1067	ATP-dependent peptidase activity
OF158_RS04450	COG2094	Belongs to the DNA glycosylase MPG family
OF158_RS04460	COG1334	flagellar protein FlaG
OF158_RS04465	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
OF158_RS04470	COG1516	flagellar protein fliS
OF158_RS04490	COG0653	protein targeting
OF158_RS04500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OF158_RS04510	COG2884	Cell division ATP-binding protein ftsE
OF158_RS04515	COG2177	Part of the ABC transporter FtsEX involved in
OF158_RS04520	COG0739	heme binding
OF158_RS04540	COG0460	homoserine dehydrogenase
OF158_RS04545	COG0793	Belongs to the peptidase S41A family
OF158_RS04545	COG3409	Peptidoglycan-binding domain 1 protein
OF158_RS04560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OF158_RS04565	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OF158_RS04570	COG4605	iron ion homeostasis
OF158_RS04575	COG4604	ABC transporter, ATP-binding protein
OF158_RS04580	COG4607	ABC-type enterochelin transport system periplasmic component
OF158_RS04595	COG0745	RESPONSE REGULATOR receiver
OF158_RS04600	COG5002	protein histidine kinase activity
OF158_RS04610	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
OF158_RS04620	COG0573	inorganic phosphate transmembrane transporter activity
OF158_RS04625	COG0581	inorganic phosphate transmembrane transporter activity
OF158_RS04635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OF158_RS04640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OF158_RS04685	COG0556	nucleotide-excision repair
OF158_RS04690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OF158_RS04695	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
OF158_RS04710	COG1682	transport, permease protein
OF158_RS04715	COG0463	Glycosyl transferase, family 2
OF158_RS04715	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
OF158_RS04720	COG3595	metallopeptidase activity
OF158_RS04730	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
OF158_RS04735	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OF158_RS04740	COG0546	phosphoglycolate phosphatase activity
OF158_RS04745	COG0110	maltose O-acetyltransferase activity
OF158_RS04750	COG0457	Tetratricopeptide repeat
OF158_RS04755	COG0492	ferredoxin-NADP+ reductase activity
OF158_RS04760	COG1051	belongs to the nudix hydrolase family
OF158_RS04765	COG1660	Displays ATPase and GTPase activities
OF158_RS04770	COG0391	Required for morphogenesis under gluconeogenic growth conditions
OF158_RS04775	COG1481	regulation of sporulation
OF158_RS04780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF158_RS04815	COG3842	ATPase activity
OF158_RS04820	COG2508	Transcriptional regulator
OF158_RS04830	COG0189	ligase activity
OF158_RS04835	COG0189	ligase activity
OF158_RS04845	COG4399	Belongs to the UPF0754 family
OF158_RS04855	COG0561	phosphatase activity
OF158_RS04860	COG1024	Enoyl-CoA hydratase
OF158_RS04870	COG0861	Integral membrane protein TerC family
OF158_RS04875	COG0701	Predicted permease
OF158_RS04880	COG3689	TIGRFAM TIGR03943 family protein
OF158_RS04885	COG0420	3'-5' exonuclease activity
OF158_RS04890	COG4717	serine-type aminopeptidase activity
OF158_RS04895	COG3481	metal-dependent phosphohydrolase, HD sub domain
OF158_RS04905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OF158_RS04920	COG1846	Transcriptional regulator
OF158_RS04945	COG0537	adenosine 5'-monophosphoramidase activity
OF158_RS04950	COG1131	(ABC) transporter
OF158_RS04955	COG4473	ABC transporter
OF158_RS04960	COG1473	amidohydrolase
OF158_RS04965	COG3069	C4-dicarboxylate transmembrane transporter activity
OF158_RS04970	COG2329	Antibiotic biosynthesis monooxygenase
OF158_RS04975	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OF158_RS04980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OF158_RS04985	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
OF158_RS04990	COG1309	transcriptional regulator
OF158_RS04995	COG1511	domain protein
OF158_RS05000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OF158_RS05000	COG1263	PTS System
OF158_RS05000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OF158_RS05000	COG2190	(PTS) system
OF158_RS05000	COG1263	PTS System
OF158_RS05000	COG2190	(PTS) system
OF158_RS05005	COG1349	DNA-binding transcription factor activity
OF158_RS05010	COG3254	rhamnose metabolic process
OF158_RS05015	COG2814	Major facilitator Superfamily
OF158_RS05020	COG0697	spore germination
OF158_RS05025	COG1012	belongs to the aldehyde dehydrogenase family
OF158_RS05030	COG1999	signal sequence binding
OF158_RS05045	COG0095	Lipoate-protein ligase
OF158_RS05050	COG0318	PFAM AMP-dependent synthetase and ligase
OF158_RS05055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OF158_RS05065	COG0501	Belongs to the peptidase M48B family
OF158_RS05085	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
OF158_RS05090	COG1074	ATP-dependent DNA helicase activity
OF158_RS05125	COG2311	Membrane
OF158_RS05130	COG0179	Fumarylacetoacetate (FAA) hydrolase
OF158_RS05145	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS05150	COG1307	EDD domain protein, DegV family
OF158_RS05170	COG0561	phosphatase activity
OF158_RS05175	COG2151	metal-sulfur cluster biosynthetic enzyme
OF158_RS05205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OF158_RS05210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OF158_RS05225	COG4608	Belongs to the ABC transporter superfamily
OF158_RS05230	COG0601	transmembrane transport
OF158_RS05240	COG0747	negative chemotaxis
OF158_RS05250	COG0180	Tryptophanyl-tRNA synthetase
OF158_RS05260	COG4166	transmembrane transport
OF158_RS05265	COG0601	transmembrane transport
OF158_RS05270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OF158_RS05275	COG0444	Belongs to the ABC transporter superfamily
OF158_RS05280	COG4608	Belongs to the ABC transporter superfamily
OF158_RS05285	COG1393	Belongs to the ArsC family
OF158_RS05290	COG4862	establishment of competence for transformation
OF158_RS05295	COG4469	Competence protein
OF158_RS05300	COG1164	Oligoendopeptidase f
OF158_RS05310	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OF158_RS05315	COG2346	COG2346, Truncated hemoglobins
OF158_RS05330	COG0741	lytic transglycosylase activity
OF158_RS05345	COG2357	RelA SpoT domain protein
OF158_RS05355	COG0564	pseudouridine synthase activity
OF158_RS05360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
OF158_RS05365	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OF158_RS05400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OF158_RS05430	COG2153	protein acetylation
OF158_RS05440	COG2382	esterase
OF158_RS05480	COG1940	carbohydrate kinase activity
OF158_RS05490	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS05495	COG4152	abc transporter atp-binding protein
OF158_RS05500	COG1668	transmembrane transport
OF158_RS05510	COG3579	cysteine-type endopeptidase activity
OF158_RS05560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OF158_RS05565	COG3344	reverse transcriptase
OF158_RS05570	COG2059	Chromate
OF158_RS05575	COG2059	Chromate
OF158_RS05580	COG1522	sequence-specific DNA binding
OF158_RS05610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OF158_RS05615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OF158_RS05640	COG1609	Transcriptional regulator
OF158_RS05650	COG1554	hydrolase, family 65, central catalytic
OF158_RS05655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OF158_RS05700	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS05715	COG1959	2 iron, 2 sulfur cluster binding
OF158_RS05725	COG0730	response to heat
OF158_RS05730	COG0783	Belongs to the Dps family
OF158_RS05735	COG0673	inositol 2-dehydrogenase activity
OF158_RS05740	COG3852	Histidine kinase
OF158_RS05745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OF158_RS05760	COG0861	Integral membrane protein TerC family
OF158_RS05780	COG5002	protein histidine kinase activity
OF158_RS05795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OF158_RS05810	COG0542	response to heat
OF158_RS05815	COG3949	Membrane
OF158_RS05825	COG4873	Protein conserved in bacteria
OF158_RS05835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF158_RS05850	COG2084	Dehydrogenase
OF158_RS05855	COG0436	Aminotransferase
OF158_RS05860	COG0784	Response regulator, receiver
OF158_RS05860	COG0835	chemotaxis
OF158_RS05870	COG2409	Drug exporters of the RND superfamily
OF158_RS05870	COG1033	growth of symbiont in host cell
OF158_RS05880	COG3300	MHYT domain
OF158_RS05880	COG5001	Diguanylate cyclase
OF158_RS05890	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS05900	COG4703	Protein of unknown function (DUF1797)
OF158_RS05905	COG0517	IMP dehydrogenase activity
OF158_RS05910	COG0583	DNA-binding transcription factor activity
OF158_RS05915	COG2171	N-acyltransferase activity
OF158_RS05920	COG1473	amidohydrolase
OF158_RS05930	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
OF158_RS05975	COG1982	Orn Lys Arg decarboxylase major
OF158_RS05985	COG4476	Belongs to the UPF0223 family
OF158_RS06000	COG0483	inositol monophosphate 1-phosphatase activity
OF158_RS06010	COG1217	gtp-binding protein TYPA
OF158_RS06020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
OF158_RS06025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
OF158_RS06030	COG4838	Belongs to the UPF0358 family
OF158_RS06035	COG0772	Belongs to the SEDS family
OF158_RS06040	COG1612	heme a metabolic process
OF158_RS06045	COG0109	protoheme IX farnesyltransferase activity
OF158_RS06050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
OF158_RS06050	COG2010	Cytochrome c
OF158_RS06065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
OF158_RS06070	COG3336	cytochrome c oxidase
OF158_RS06080	COG2340	Cysteine-rich secretory protein family
OF158_RS06085	COG2050	protein possibly involved in aromatic compounds catabolism
OF158_RS06105	COG3679	Belongs to the UPF0342 family
OF158_RS06110	COG4471	UPF0298 protein
OF158_RS06120	COG0742	ribosomal rna small subunit methyltransferase
OF158_RS06125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OF158_RS06130	COG3314	Sporulation integral membrane protein YlbJ
OF158_RS06135	COG1752	Esterase of the alpha-beta hydrolase superfamily
OF158_RS06140	COG3480	Lon protease (S16) C-terminal proteolytic domain
OF158_RS06145	COG1323	Belongs to the UPF0348 family
OF158_RS06150	COG1399	metal-binding, possibly nucleic acid-binding protein
OF158_RS06155	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OF158_RS06165	COG0454	-acetyltransferase
OF158_RS06170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OF158_RS06175	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
OF158_RS06180	COG2001	Belongs to the MraZ family
OF158_RS06185	COG0275	rRNA processing
OF158_RS06190	COG4839	cell division protein FtsL
OF158_RS06195	COG0768	penicillin binding
OF158_RS06200	COG0768	penicillin binding
OF158_RS06215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OF158_RS06220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OF158_RS06225	COG0772	Belongs to the SEDS family
OF158_RS06230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OF158_RS06235	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OF158_RS06240	COG0849	cell division
OF158_RS06245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OF158_RS06260	COG1191	sigma factor activity
OF158_RS06265	COG1191	sigma factor activity
OF158_RS06270	COG1873	PFAM PRC-barrel domain
OF158_RS06275	COG3584	3D domain protein
OF158_RS06275	COG1388	LysM domain
OF158_RS06285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OF158_RS06290	COG1799	cell septum assembly
OF158_RS06295	COG0762	integral membrane protein
OF158_RS06300	COG2302	S4 RNA-binding domain
OF158_RS06305	COG3599	regulation of cell shape
OF158_RS06320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OF158_RS06325	COG0564	pseudouridine synthase activity
OF158_RS06340	COG0540	Belongs to the ATCase OTCase family
OF158_RS06345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OF158_RS06365	COG0167	dihydroorotate dehydrogenase activity
OF158_RS06370	COG0284	orotidine-5'-phosphate decarboxylase activity
OF158_RS06375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OF158_RS06400	COG1917	Cupin 2, conserved barrel domain protein
OF158_RS06400	COG2207	Transcriptional regulator
OF158_RS06405	COG1070	Carbohydrate kinase
OF158_RS06410	COG4806	L-rhamnose isomerase
OF158_RS06415	COG0235	Class ii aldolase
OF158_RS06420	COG1803	Methylglyoxal synthase
OF158_RS06440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OF158_RS06445	COG0477	Major facilitator Superfamily
OF158_RS06450	COG0477	Major facilitator Superfamily
OF158_RS06455	COG1309	transcriptional regulator
OF158_RS06465	COG2076	Multidrug Resistance protein
OF158_RS06475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OF158_RS06480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OF158_RS06495	COG0628	permease
OF158_RS06500	COG0561	phosphatase activity
OF158_RS06535	COG0720	synthase
OF158_RS06545	COG0385	Bile acid
OF158_RS06555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OF158_RS06560	COG1561	YicC-like family, N-terminal region
OF158_RS06565	COG2052	Domain of unknown function (DUF370)
OF158_RS06570	COG0194	GDP metabolic process
OF158_RS06575	COG1758	RNA polymerase activity
OF158_RS06580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OF158_RS06585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OF158_RS06590	COG0242	peptide deformylase activity
OF158_RS06595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OF158_RS06600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OF158_RS06600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OF158_RS06605	COG0631	protein serine/threonine phosphatase activity
OF158_RS06610	COG2815	serine threonine protein kinase
OF158_RS06610	COG0515	serine threonine protein kinase
OF158_RS06620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OF158_RS06625	COG1564	THIamine pyrophosphokinase
OF158_RS06635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OF158_RS06640	COG1302	Protein conserved in bacteria
OF158_RS06645	COG1461	Dihydroxyacetone kinase
OF158_RS06650	COG1760	l-serine dehydratase
OF158_RS06655	COG1760	l-serine dehydratase
OF158_RS06660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OF158_RS06665	COG1349	DNA-binding transcription factor activity
OF158_RS06670	COG0416	fatty acid biosynthetic process
OF158_RS06675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OF158_RS06680	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS06690	COG0571	ribonuclease III activity
OF158_RS06695	COG1196	nuclear chromosome segregation
OF158_RS06700	COG0552	protein localization to endoplasmic reticulum
OF158_RS06705	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
OF158_RS06710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OF158_RS06720	COG1837	Belongs to the UPF0109 family
OF158_RS06730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OF158_RS06735	COG0336	Belongs to the RNA methyltransferase TrmD family
OF158_RS06750	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
OF158_RS06765	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OF158_RS06770	COG0045	succinate-CoA ligase (ADP-forming) activity
OF158_RS06775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OF158_RS06780	COG0758	DNA mediated transformation
OF158_RS06785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OF158_RS06795	COG4974	Belongs to the 'phage' integrase family
OF158_RS06800	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
OF158_RS06810	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
OF158_RS06815	COG1815	bacterial-type flagellum-dependent cell motility
OF158_RS06820	COG1558	bacterial-type flagellum-dependent cell motility
OF158_RS06825	COG1677	Flagellar hook-basal body complex protein FliE
OF158_RS06830	COG1766	The M ring may be actively involved in energy transduction
OF158_RS06835	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OF158_RS06845	COG1317	bacterial-type flagellum organization
OF158_RS06850	COG1157	protein secretion by the type III secretion system
OF158_RS06855	COG2882	bacterial-type flagellum organization
OF158_RS06870	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
OF158_RS06880	COG4786	Flagellar basal body rod
OF158_RS06890	COG1580	Controls the rotational direction of flagella during chemotaxis
OF158_RS06895	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OF158_RS06900	COG1776	CheC inhibitor of MCP methylation
OF158_RS06900	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
OF158_RS06905	COG2201	protein-glutamate methylesterase activity
OF158_RS06910	COG3190	flagellar
OF158_RS06915	COG1338	Plays a role in the flagellum-specific transport system
OF158_RS06920	COG1987	bacterial-type flagellum assembly
OF158_RS06925	COG1684	flagellar biosynthetic protein fliR
OF158_RS06930	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OF158_RS06935	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
OF158_RS06940	COG1419	protein localization to endoplasmic reticulum
OF158_RS06945	COG0455	bacterial-type flagellum organization
OF158_RS06950	COG2201	protein-glutamate methylesterase activity
OF158_RS06955	COG0643	Histidine kinase
OF158_RS06955	COG2198	Histidine kinase
OF158_RS06960	COG0835	chemotaxis
OF158_RS06965	COG1776	CheC inhibitor of MCP methylation
OF158_RS06970	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
OF158_RS06975	COG1191	sigma factor activity
OF158_RS06985	COG0052	Belongs to the universal ribosomal protein uS2 family
OF158_RS06990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OF158_RS06995	COG0528	UMP kinase activity
OF158_RS07000	COG0233	cytoplasmic translational termination
OF158_RS07005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OF158_RS07010	COG4589	Belongs to the CDS family
OF158_RS07020	COG0750	zinc metalloprotease
OF158_RS07025	COG0442	prolyl-tRNA aminoacylation
OF158_RS07030	COG2176	DNA-directed DNA polymerase activity
OF158_RS07035	COG0779	Required for maturation of 30S ribosomal subunits
OF158_RS07040	COG0195	Participates in both transcription termination and antitermination
OF158_RS07045	COG2740	Nucleic-acid-binding protein implicated in transcription termination
OF158_RS07050	COG1358	cellular component organization or biogenesis
OF158_RS07060	COG1550	Protein conserved in bacteria
OF158_RS07065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OF158_RS07070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OF158_RS07075	COG0196	riboflavin kinase activity
OF158_RS07080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OF158_RS07085	COG1185	polyribonucleotide nucleotidyltransferase activity
OF158_RS07090	COG0726	polysaccharide deacetylase
OF158_RS07095	COG0612	Peptidase, M16
OF158_RS07100	COG1873	PFAM PRC-barrel domain
OF158_RS07105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OF158_RS07110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OF158_RS07115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OF158_RS07120	COG0527	aspartate kinase activity
OF158_RS07130	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
OF158_RS07135	COG0740	serine-type endopeptidase activity
OF158_RS07145	COG1674	ftsk spoiiie
OF158_RS07145	COG4980	gas vesicle protein
OF158_RS07150	COG1744	ABC transporter substrate-binding protein PnrA-like
OF158_RS07155	COG3845	ABC transporter
OF158_RS07160	COG4603	Belongs to the binding-protein-dependent transport system permease family
OF158_RS07165	COG1079	Belongs to the binding-protein-dependent transport system permease family
OF158_RS07170	COG0612	Peptidase, M16
OF158_RS07175	COG0612	Peptidase, M16
OF158_RS07180	COG0300	oxidoreductase activity
OF158_RS07195	COG1426	Protein conserved in bacteria
OF158_RS07200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OF158_RS07205	COG1058	Belongs to the CinA family
OF158_RS07205	COG1546	Belongs to the CinA family
OF158_RS07215	COG1418	mRNA catabolic process
OF158_RS07220	COG1692	metallophosphoesterase
OF158_RS07225	COG2359	stage V sporulation protein S
OF158_RS07230	COG0826	peptidase U32
OF158_RS07235	COG0826	peptidase U32
OF158_RS07240	COG0531	amino acid
OF158_RS07245	COG3829	transcription factor binding
OF158_RS07250	COG1012	belongs to the aldehyde dehydrogenase family
OF158_RS07260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OF158_RS07265	COG4550	Control of competence regulator ComK, YlbF/YmcA
OF158_RS07280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OF158_RS07285	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OF158_RS07310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OF158_RS07320	COG0464	growth
OF158_RS07325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OF158_RS07330	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
OF158_RS07335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OF158_RS07355	COG1321	iron dependent repressor
OF158_RS07360	COG2759	Belongs to the formate--tetrahydrofolate ligase family
OF158_RS07370	COG1418	mRNA catabolic process
OF158_RS07375	COG0488	(ABC) transporter
OF158_RS07380	COG1413	lyase activity
OF158_RS07395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OF158_RS07400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
OF158_RS07405	COG1272	protein, Hemolysin III
OF158_RS07410	COG2755	lipolytic protein G-D-S-L family
OF158_RS07420	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
OF158_RS07420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OF158_RS07425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OF158_RS07430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OF158_RS07440	COG0840	transmembrane signaling receptor activity
OF158_RS07445	COG4479	Belongs to the UPF0346 family
OF158_RS07460	COG1876	peptidase activity
OF158_RS07465	COG3409	Peptidoglycan-binding domain 1 protein
OF158_RS07465	COG0793	Belongs to the peptidase S41A family
OF158_RS07470	COG1846	Transcriptional regulator
OF158_RS07475	COG2340	Cysteine-rich secretory protein family
OF158_RS07480	COG0534	Mate efflux family protein
OF158_RS07495	COG1793	dna ligase
OF158_RS07495	COG3285	dna ligase
OF158_RS07500	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
OF158_RS07505	COG0671	phosphoesterase, PA-phosphatase related
OF158_RS07510	COG1368	sulfuric ester hydrolase activity
OF158_RS07515	COG1331	Highly conserved protein containing a thioredoxin domain
OF158_RS07520	COG2814	Major facilitator Superfamily
OF158_RS07525	COG0745	RESPONSE REGULATOR receiver
OF158_RS07530	COG5002	protein histidine kinase activity
OF158_RS07540	COG0567	Dehydrogenase, E1 component
OF158_RS07545	COG0508	dehydrogenase complex catalyzes the overall conversion of
OF158_RS07550	COG1012	belongs to the aldehyde dehydrogenase family
OF158_RS07575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OF158_RS07590	COG1054	Belongs to the UPF0176 family
OF158_RS07595	COG2135	peptidase activity
OF158_RS07605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OF158_RS07610	COG0517	IMP dehydrogenase activity
OF158_RS07610	COG0516	GMP reductase activity
OF158_RS07615	COG0723	plastoquinol--plastocyanin reductase activity
OF158_RS07615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OF158_RS07620	COG3584	3D domain protein
OF158_RS07620	COG1388	LysM domain
OF158_RS07625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OF158_RS07630	COG1113	amino acid transport
OF158_RS07635	COG1280	lysine exporter protein (LysE YggA)
OF158_RS07640	COG0598	Magnesium transport protein CorA
OF158_RS07650	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
OF158_RS07655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OF158_RS07660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OF158_RS07665	COG0131	Imidazoleglycerol-phosphate dehydratase
OF158_RS07670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OF158_RS07680	COG0107	imidazoleglycerol-phosphate synthase activity
OF158_RS07685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OF158_RS07685	COG0140	phosphoribosyl-ATP diphosphatase activity
OF158_RS07695	COG2391	methyltransferase activity
OF158_RS07700	COG2962	Rard protein
OF158_RS07705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OF158_RS07710	COG0569	domain protein
OF158_RS07730	COG2807	transmembrane transport
OF158_RS07735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
OF158_RS07745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OF158_RS07755	COG1278	Cold shock
OF158_RS07760	COG0302	gtp cyclohydrolase
OF158_RS07765	COG3634	alkyl hydroperoxide reductase activity
OF158_RS07780	COG0577	efflux transmembrane transporter activity
OF158_RS07785	COG1136	(ABC) transporter
OF158_RS07790	COG0642	Histidine kinase
OF158_RS07795	COG0745	RESPONSE REGULATOR receiver
OF158_RS07815	COG3328	transposase activity
OF158_RS07825	COG0640	Transcriptional regulator
OF158_RS07830	COG2814	Major facilitator Superfamily
OF158_RS07835	COG5039	Polysaccharide pyruvyl transferase
OF158_RS07845	COG1113	amino acid transport
OF158_RS07860	COG0477	Major facilitator Superfamily
OF158_RS07870	COG1132	(ABC) transporter
OF158_RS07875	COG1132	(ABC) transporter
OF158_RS07885	COG1380	Effector of murein hydrolase LrgA
OF158_RS07890	COG1346	cytolysis
OF158_RS07895	COG0318	PFAM AMP-dependent synthetase and ligase
OF158_RS07920	COG2309	aminopeptidase activity
OF158_RS07930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OF158_RS07950	COG0824	Thioesterase
OF158_RS07960	COG4841	protein insertion into membrane
OF158_RS07965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OF158_RS07975	COG1832	CoA-binding protein
OF158_RS07980	COG0187	DNA topoisomerase II activity
OF158_RS07985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OF158_RS08000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OF158_RS08005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OF158_RS08005	COG0574	Belongs to the PEP-utilizing enzyme family
OF158_RS08030	COG2070	2-Nitropropane dioxygenase
OF158_RS08040	COG0681	Belongs to the peptidase S26 family
OF158_RS08050	COG2226	methyltransferase
OF158_RS08075	COG0456	acetyltransferase
OF158_RS08080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OF158_RS08085	COG0456	acetyltransferase
OF158_RS08090	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS08095	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
OF158_RS08100	COG0351	phosphomethylpyrimidine kinase
OF158_RS08105	COG0352	thiamine-phosphate diphosphorylase activity
OF158_RS08110	COG2258	MOSC domain
OF158_RS08145	COG1309	transcriptional regulator
OF158_RS08150	COG2814	Major facilitator Superfamily
OF158_RS08155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OF158_RS08160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OF158_RS08170	COG1809	phosphosulfolactate synthase activity
OF158_RS08175	COG2045	Belongs to the ComB family
OF158_RS08180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
OF158_RS08185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OF158_RS08195	COG0789	Transcriptional regulator
OF158_RS08200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OF158_RS08205	COG0697	spore germination
OF158_RS08210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OF158_RS08215	COG0022	dehydrogenase e1 component
OF158_RS08220	COG0508	dehydrogenase complex catalyzes the overall conversion of
OF158_RS08225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OF158_RS08230	COG3284	Transcriptional regulator
OF158_RS08235	COG3264	Mechanosensitive ion channel
OF158_RS08235	COG1511	domain protein
OF158_RS08250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OF158_RS08255	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
OF158_RS08270	COG0183	Belongs to the thiolase family
OF158_RS08275	COG0318	PFAM AMP-dependent synthetase and ligase
OF158_RS08290	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OF158_RS08295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OF158_RS08300	COG2508	Transcriptional regulator
OF158_RS08305	COG2233	PERMEase
OF158_RS08315	COG2072	flavoprotein involved in K transport
OF158_RS08325	COG0561	phosphatase activity
OF158_RS08330	COG2322	membrane
OF158_RS08345	COG0039	L-malate dehydrogenase activity
OF158_RS08350	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS08355	COG2223	nitrite transmembrane transporter activity
OF158_RS08360	COG3773	Cell wall hydrolase
OF158_RS08365	COG0708	Exodeoxyribonuclease III
OF158_RS08375	COG0297	glycogen (starch) synthase activity
OF158_RS08380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OF158_RS08385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
OF158_RS08390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
OF158_RS08410	COG1247	-acetyltransferase
OF158_RS08415	COG0494	nUDIX hydrolase
OF158_RS08420	COG1914	H( )-stimulated, divalent metal cation uptake system
OF158_RS08425	COG0783	Belongs to the Dps family
OF158_RS08435	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
OF158_RS08440	COG1131	(ABC) transporter
OF158_RS08465	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OF158_RS08475	COG2030	dehydratase
OF158_RS08480	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS08495	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
OF158_RS08500	COG0709	Synthesizes selenophosphate from selenide and ATP
OF158_RS08515	COG0701	Predicted permease
OF158_RS08525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OF158_RS08530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OF158_RS08540	COG1252	NADH dehydrogenase
OF158_RS08545	COG2404	hydrolase activity, acting on ester bonds
OF158_RS08555	COG4990	cell redox homeostasis
OF158_RS08560	COG0789	Transcriptional regulator
OF158_RS08585	COG0436	Aminotransferase
OF158_RS08590	COG0165	Argininosuccinate lyase
OF158_RS08595	COG0137	argininosuccinate synthase activity
OF158_RS08600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OF158_RS08610	COG0505	Belongs to the CarA family
OF158_RS08615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OF158_RS08620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OF158_RS08625	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
OF158_RS08630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OF158_RS08645	COG3546	catalase activity
OF158_RS08665	COG1619	proteins homologs of microcin C7 resistance protein MccF
OF158_RS08670	COG2027	D-alanyl-D-alanine carboxypeptidase
OF158_RS08675	COG0204	Acyl-transferase
OF158_RS08685	COG4846	Membrane protein involved in cytochrome C biogenesis
OF158_RS08690	COG2201	protein-glutamate methylesterase activity
OF158_RS08695	COG0785	Cytochrome C biogenesis protein
OF158_RS08700	COG3763	UPF0154 protein
OF158_RS08715	COG4224	UPF0291 protein
OF158_RS08720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OF158_RS08730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OF158_RS08740	COG1388	LysM domain
OF158_RS08740	COG0791	NLP P60 protein
OF158_RS08790	COG5280	Phage tail tape measure protein TP901
OF158_RS08790	COG3953	SLT domain
OF158_RS08830	COG0740	serine-type endopeptidase activity
OF158_RS08865	COG0582	viral genome integration into host DNA
OF158_RS08870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
OF158_RS08950	COG1396	sequence-specific DNA binding
OF158_RS08960	COG2176	DNA-directed DNA polymerase activity
OF158_RS08965	COG0556	nucleotide-excision repair
OF158_RS08980	COG0582	viral genome integration into host DNA
OF158_RS08985	COG0174	glutamine synthetase
OF158_RS08990	COG0789	Transcriptional regulator
OF158_RS08995	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
OF158_RS09010	COG2233	PERMEase
OF158_RS09020	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
OF158_RS09025	COG0116	Belongs to the methyltransferase superfamily
OF158_RS09040	COG4474	Belongs to the UPF0398 family
OF158_RS09050	COG3359	exonuclease
OF158_RS09055	COG1111	helicase
OF158_RS09055	COG1205	dead DEAH box helicase
OF158_RS09060	COG0071	Belongs to the small heat shock protein (HSP20) family
OF158_RS09085	COG3331	DNA recombination
OF158_RS09090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OF158_RS09090	COG4499	WXG100 protein secretion system (Wss), protein YukC
OF158_RS09095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OF158_RS09100	COG3935	DnaD domain protein
OF158_RS09105	COG3344	reverse transcriptase
OF158_RS09110	COG0017	Asparaginyl-tRNA synthetase
OF158_RS09125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OF158_RS09125	COG1199	ATP-dependent helicase activity
OF158_RS09130	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OF158_RS09135	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
OF158_RS09155	COG0438	transferase activity, transferring glycosyl groups
OF158_RS09160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
OF158_RS09165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OF158_RS09170	COG1694	Mazg nucleotide pyrophosphohydrolase
OF158_RS09175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OF158_RS09185	COG2738	Putative neutral zinc metallopeptidase
OF158_RS09195	COG4347	Protein of unknown function (DUF1405)
OF158_RS09205	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
OF158_RS09220	COG5582	Belongs to the UPF0302 family
OF158_RS09225	COG0457	Tetratricopeptide repeat
OF158_RS09230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OF158_RS09235	COG0287	Prephenate dehydrogenase
OF158_RS09240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OF158_RS09245	COG4401	Chorismate mutase type I
OF158_RS09250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
OF158_RS09255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OF158_RS09260	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OF158_RS09265	COG0105	UTP biosynthetic process
OF158_RS09270	COG0142	geranyltranstransferase activity
OF158_RS09275	COG2226	methyltransferase
OF158_RS09280	COG0142	geranyltranstransferase activity
OF158_RS09290	COG0776	regulation of translation
OF158_RS09295	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
OF158_RS09315	COG1160	GTP binding
OF158_RS09330	COG0539	negative regulation of cytoplasmic translation
OF158_RS09335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OF158_RS09340	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
OF158_RS09345	COG2959	enzyme of heme biosynthesis
OF158_RS09350	COG3773	Cell wall hydrolase
OF158_RS09350	COG3409	Peptidoglycan-binding domain 1 protein
OF158_RS09355	COG2339	peptidase activity
OF158_RS09360	COG0492	ferredoxin-NADP+ reductase activity
OF158_RS09365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OF158_RS09375	COG1408	metallophosphoesterase
OF158_RS09390	COG3546	catalase activity
OF158_RS09405	COG1266	CAAX protease self-immunity
OF158_RS09410	COG0514	ATP-dependent DNA helicase (RecQ)
OF158_RS09420	COG1141	Ferredoxin
OF158_RS09425	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
OF158_RS09430	COG0739	heme binding
OF158_RS09430	COG0741	lytic transglycosylase activity
OF158_RS09430	COG1196	nuclear chromosome segregation
OF158_RS09435	COG5002	protein histidine kinase activity
OF158_RS09440	COG0745	RESPONSE REGULATOR receiver
OF158_RS09445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OF158_RS09450	COG1333	cytochrome c biogenesis protein
OF158_RS09455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF158_RS09460	COG1187	pseudouridine synthase activity
OF158_RS09465	COG0700	Nucleoside recognition
OF158_RS09470	COG2715	membrane protein required for spore maturation
OF158_RS09475	COG1686	Belongs to the peptidase S11 family
OF158_RS09480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OF158_RS09505	COG0697	spore germination
OF158_RS09525	COG1191	sigma factor activity
OF158_RS09540	COG1686	Belongs to the peptidase S11 family
OF158_RS09545	COG4974	Belongs to the 'phage' integrase family
OF158_RS09555	COG0735	belongs to the Fur family
OF158_RS09560	COG1300	Membrane
OF158_RS09565	COG1379	DNA repair
OF158_RS09580	COG0667	Aldo Keto reductase
OF158_RS09590	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
OF158_RS09595	COG3853	Toxic anion resistance protein (TelA)
OF158_RS09600	COG1073	alpha beta
OF158_RS09605	COG3858	chitin binding
OF158_RS09605	COG1388	LysM domain
OF158_RS09615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OF158_RS09620	COG0300	oxidoreductase activity
OF158_RS09625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OF158_RS09635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OF158_RS09640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OF158_RS09650	COG2195	Cleaves the N-terminal amino acid of tripeptides
OF158_RS09665	COG1376	ErfK ybiS ycfS ynhG family protein
OF158_RS09675	COG1105	Belongs to the carbohydrate kinase PfkB family
OF158_RS09680	COG0508	dehydrogenase complex catalyzes the overall conversion of
OF158_RS09685	COG0022	dehydrogenase e1 component
OF158_RS09690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OF158_RS09695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OF158_RS09715	COG0584	glycerophosphoryl diester phosphodiesterase
OF158_RS09720	COG0745	RESPONSE REGULATOR receiver
OF158_RS09725	COG0750	zinc metalloprotease
OF158_RS09730	COG0497	DNA recombination
OF158_RS09740	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
OF158_RS09745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OF158_RS09760	COG1570	exodeoxyribonuclease VII activity
OF158_RS09775	COG1302	Protein conserved in bacteria
OF158_RS09780	COG0439	Biotin carboxylase
OF158_RS09785	COG0511	ligase activity, forming carbon-carbon bonds
OF158_RS09825	COG3854	ATPases associated with a variety of cellular activities
OF158_RS09830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OF158_RS09835	COG0006	proline dipeptidase activity
OF158_RS09840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
OF158_RS09850	COG3872	metal-dependent enzyme
OF158_RS09860	COG1752	Esterase of the alpha-beta hydrolase superfamily
OF158_RS09870	COG3327	negative regulation of DNA-templated transcription, initiation
OF158_RS09875	COG0183	Belongs to the thiolase family
OF158_RS09880	COG1250	3-hydroxyacyl-CoA dehydrogenase
OF158_RS09885	COG1012	belongs to the aldehyde dehydrogenase family
OF158_RS09890	COG1024	Enoyl-CoA hydratase
OF158_RS09900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OF158_RS09905	COG0095	Lipoate-protein ligase
OF158_RS09910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OF158_RS09915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OF158_RS09925	COG0404	The glycine cleavage system catalyzes the degradation of glycine
OF158_RS09930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OF158_RS09945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OF158_RS09970	COG4537	Required for transformation and DNA binding
OF158_RS09975	COG1459	type II secretion system
OF158_RS09980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OF158_RS09995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OF158_RS10005	COG1940	carbohydrate kinase activity
OF158_RS10010	COG4483	Protein conserved in bacteria
OF158_RS10015	COG0457	Tetratricopeptide repeat
OF158_RS10015	COG0705	Rhomboid family
OF158_RS10025	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OF158_RS10035	COG0768	penicillin binding
OF158_RS10040	COG0477	Major facilitator Superfamily
OF158_RS10045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OF158_RS10055	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
OF158_RS10060	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
OF158_RS10065	COG0735	belongs to the Fur family
OF158_RS10070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OF158_RS10075	COG1121	(ABC) transporter
OF158_RS10085	COG0791	NLP P60 protein
OF158_RS10085	COG3883	PFAM NLP P60 protein
OF158_RS10090	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
OF158_RS10095	COG0513	Belongs to the DEAD box helicase family
OF158_RS10105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OF158_RS10110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OF158_RS10115	COG2384	SAM-dependent methyltransferase
OF158_RS10120	COG2010	Cytochrome c
OF158_RS10130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OF158_RS10135	COG0358	DNA primase activity
OF158_RS10145	COG0517	IMP dehydrogenase activity
OF158_RS10150	COG1381	Involved in DNA repair and RecF pathway recombination
OF158_RS10165	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OF158_RS10170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OF158_RS10175	COG1480	7TM receptor with intracellular HD hydrolase
OF158_RS10180	COG1702	phosphate starvation-inducible protein PhoH
OF158_RS10195	COG1610	YqeY-like protein
OF158_RS10210	COG1283	sodium-dependent phosphate transmembrane transporter activity
OF158_RS10215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OF158_RS10220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OF158_RS10225	COG2264	protein methyltransferase activity
OF158_RS10235	COG0443	Heat shock 70 kDa protein
OF158_RS10240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OF158_RS10250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OF158_RS10255	COG0481	GTPase activity
OF158_RS10260	COG0860	N-Acetylmuramoyl-L-alanine amidase
OF158_RS10265	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
OF158_RS10270	COG0268	Binds directly to 16S ribosomal RNA
OF158_RS10275	COG1466	dna polymerase III delta subunit
OF158_RS10285	COG0658	competence protein
OF158_RS10285	COG2333	competence protein COMEC
OF158_RS10290	COG2131	deaminase
OF158_RS10295	COG1555	photosystem II stabilization
OF158_RS10295	COG1596	polysaccharide export
OF158_RS10300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OF158_RS10305	COG2226	methyltransferase
OF158_RS10310	COG0799	negative regulation of ribosome biogenesis
OF158_RS10315	COG1713	HD superfamily hydrolase involved in NAD metabolism
OF158_RS10320	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OF158_RS10325	COG1534	Rna-binding protein
OF158_RS10335	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
OF158_RS10340	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
OF158_RS10345	COG0247	lactate metabolic process
OF158_RS10350	COG0277	FAD linked oxidase domain protein
OF158_RS10355	COG3835	regulator
OF158_RS10360	COG2132	Multicopper oxidase
OF158_RS10365	COG0071	Belongs to the small heat shock protein (HSP20) family
OF158_RS10375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF158_RS10415	COG1183	phosphatidylcholine synthase activity
OF158_RS10430	COG3634	alkyl hydroperoxide reductase activity
OF158_RS10435	COG0450	alkyl hydroperoxide reductase
OF158_RS10465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OF158_RS10470	COG0572	uridine kinase
OF158_RS10475	COG4122	O-methyltransferase activity
OF158_RS10480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OF158_RS10485	COG3906	Belongs to the UPF0473 family
OF158_RS10490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OF158_RS10495	COG4472	Bacterial protein of unknown function (DUF965)
OF158_RS10500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OF158_RS10505	COG0628	permease
OF158_RS10535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OF158_RS10545	COG0482	sulfurtransferase activity
OF158_RS10550	COG1104	cysteine desulfurase activity
OF158_RS10555	COG1959	2 iron, 2 sulfur cluster binding
OF158_RS10565	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS10570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OF158_RS10575	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OF158_RS10580	COG0385	Bile acid
OF158_RS10590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OF158_RS10595	COG0124	histidyl-tRNA synthetase
OF158_RS10605	COG4991	sh3 domain protein
OF158_RS10605	COG0860	N-Acetylmuramoyl-L-alanine amidase
OF158_RS10605	COG3103	Sh3 type 3 domain protein
OF158_RS10610	COG2814	Major facilitator Superfamily
OF158_RS10615	COG1566	PFAM secretion protein HlyD family protein
OF158_RS10620	COG1846	Transcriptional regulator
OF158_RS10625	COG1490	D-aminoacyl-tRNA deacylase activity
OF158_RS10630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OF158_RS10635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OF158_RS10640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OF158_RS10640	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
OF158_RS10650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OF158_RS10650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OF158_RS10660	COG2244	polysaccharide biosynthetic process
OF158_RS10665	COG2323	membrane
OF158_RS10675	COG1862	Preprotein translocase
OF158_RS10680	COG0343	queuine tRNA-ribosyltransferase activity
OF158_RS10685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
OF158_RS10700	COG0632	four-way junction helicase activity
OF158_RS10705	COG0217	transcriptional regulatory protein
OF158_RS10720	COG1827	regulation of RNA biosynthetic process
OF158_RS10725	COG0077	Prephenate dehydratase
OF158_RS10730	COG4492	Belongs to the UPF0735 family
OF158_RS10735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OF158_RS10740	COG3290	protein histidine kinase activity
OF158_RS10745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OF158_RS10750	COG2868	ribosomal protein
OF158_RS10755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OF158_RS10760	COG1530	ribonuclease E activity
OF158_RS10765	COG1994	Peptidase M50
OF158_RS10775	COG2894	cell division
OF158_RS10780	COG0850	regulation of cytokinetic process
OF158_RS10790	COG1792	Involved in formation and maintenance of cell shape
OF158_RS10795	COG1077	Cell shape determining protein MreB Mrl
OF158_RS10800	COG2003	Belongs to the UPF0758 family
OF158_RS10810	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
OF158_RS10835	COG1459	type II secretion system
OF158_RS10845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OF158_RS10880	COG0285	dihydrofolate synthase activity
OF158_RS10895	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OF158_RS10900	COG1388	LysM domain
OF158_RS10900	COG1388	LysM domain
OF158_RS10905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OF158_RS10910	COG0113	porphobilinogen synthase activity
OF158_RS10920	COG0181	hydroxymethylbilane synthase activity
OF158_RS10925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
OF158_RS10940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OF158_RS10945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
OF158_RS10950	COG0470	DNA polymerase III
OF158_RS10950	COG1067	ATP-dependent peptidase activity
OF158_RS10960	COG0544	peptidyl-prolyl cis-trans isomerase activity
OF158_RS10965	COG0457	Tetratricopeptide repeat
OF158_RS10965	COG1477	protein flavinylation
OF158_RS10995	COG0622	Phosphoesterase
OF158_RS11000	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OF158_RS11005	COG5401	PFAM Sporulation and spore germination
OF158_RS11015	COG5577	PFAM Coat F domain
OF158_RS11020	COG1063	alcohol dehydrogenase
OF158_RS11025	COG5577	PFAM Coat F domain
OF158_RS11040	COG1846	Transcriptional regulator
OF158_RS11065	COG2197	response regulator
OF158_RS11070	COG0824	Thioesterase
OF158_RS11075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OF158_RS11080	COG1053	succinate dehydrogenase
OF158_RS11085	COG2009	succinate dehydrogenase
OF158_RS11090	COG1719	4-vinyl reductase, 4VR
OF158_RS11100	COG0322	excinuclease ABC activity
OF158_RS11105	COG3118	belongs to the thioredoxin family
OF158_RS11115	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
OF158_RS11120	COG2086	electron transfer activity
OF158_RS11125	COG1024	Enoyl-CoA hydratase
OF158_RS11130	COG1309	transcriptional regulator
OF158_RS11140	COG1193	negative regulation of DNA recombination
OF158_RS11145	COG1796	DNA polymerase
OF158_RS11145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
OF158_RS11150	COG1286	toxin biosynthetic process
OF158_RS11155	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
OF158_RS11165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OF158_RS11165	COG0072	phenylalanine-tRNA ligase activity
OF158_RS11170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OF158_RS11180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OF158_RS11215	COG2329	Antibiotic biosynthesis monooxygenase
OF158_RS11225	COG1695	Transcriptional regulator
OF158_RS11245	COG0431	NADPH-dependent FMN reductase
OF158_RS11280	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
OF158_RS11290	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OF158_RS11300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OF158_RS11310	COG1484	DNA-dependent DNA replication
OF158_RS11315	COG3611	Membrane attachment protein
OF158_RS11320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OF158_RS11325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
OF158_RS11330	COG0237	dephospho-CoA kinase activity
OF158_RS11335	COG1971	Probably functions as a manganese efflux pump
OF158_RS11340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OF158_RS11345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OF158_RS11345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OF158_RS11350	COG0039	L-malate dehydrogenase activity
OF158_RS11355	COG0538	isocitrate dehydrogenase activity
OF158_RS11360	COG0372	Belongs to the citrate synthase family
OF158_RS11365	COG2707	UPF0756 membrane protein
OF158_RS11370	COG0628	permease
OF158_RS11380	COG0205	6-phosphofructokinase activity
OF158_RS11385	COG0825	malonyl-CoA metabolic process
OF158_RS11390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OF158_RS11395	COG0281	malic enzyme
OF158_RS11400	COG0587	DNA-directed DNA polymerase activity
OF158_RS11415	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
OF158_RS11425	COG4109	DRTGG domain
OF158_RS11430	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
OF158_RS11435	COG0006	proline dipeptidase activity
OF158_RS11445	COG0589	response to stress
OF158_RS11455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OF158_RS11460	COG0827	DNA restriction-modification system
OF158_RS11465	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
OF158_RS11470	COG3874	Sporulation protein YtfJ
OF158_RS11480	COG1714	RDD family
OF158_RS11485	COG0616	signal peptide processing
OF158_RS11490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OF158_RS11500	COG0301	tRNA thio-modification
OF158_RS11505	COG1104	cysteine desulfurase activity
OF158_RS11510	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
OF158_RS11515	COG1309	transcriptional regulator
OF158_RS11520	COG1956	GAF domain-containing protein
OF158_RS11525	COG2203	Gaf domain
OF158_RS11525	COG2199	diguanylate cyclase activity
OF158_RS11535	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OF158_RS11545	COG0506	proline dehydrogenase activity
OF158_RS11550	COG1012	belongs to the aldehyde dehydrogenase family
OF158_RS11555	COG3290	protein histidine kinase activity
OF158_RS11555	COG3829	transcription factor binding
OF158_RS11565	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
OF158_RS11570	COG3383	formate dehydrogenase (NAD+) activity
OF158_RS11575	COG2427	Protein of unknown function (DUF1641)
OF158_RS11580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
OF158_RS11585	COG0315	cyclic pyranopterin monophosphate synthase activity
OF158_RS11590	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
OF158_RS11595	COG0314	molybdopterin synthase activity
OF158_RS11600	COG1763	Mo-molybdopterin cofactor biosynthetic process
OF158_RS11605	COG0303	'Molybdopterin
OF158_RS11620	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OF158_RS11625	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
OF158_RS11630	COG4149	molybdate abc transporter
OF158_RS11640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OF158_RS11645	COG0454	-acetyltransferase
OF158_RS11650	COG0517	IMP dehydrogenase activity
OF158_RS11655	COG0123	including yeast histone deacetylase and acetoin utilization protein
OF158_RS11665	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
OF158_RS11665	COG1605	Chorismate mutase
OF158_RS11670	COG4980	gas vesicle protein
OF158_RS11680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OF158_RS11685	COG1674	ftsk spoiiie
OF158_RS11695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OF158_RS11700	COG4848	Belongs to the UPF0354 family
OF158_RS11705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF158_RS11710	COG2208	phosphoserine phosphatase activity
OF158_RS11715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
OF158_RS11720	COG0784	Response regulator, receiver
OF158_RS11720	COG5002	protein histidine kinase activity
OF158_RS11740	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
OF158_RS11745	COG1363	Peptidase, m42
OF158_RS11750	COG5584	Small secreted protein
OF158_RS11755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OF158_RS11760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OF158_RS11770	COG0510	thiamine kinase activity
OF158_RS11795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OF158_RS11800	COG1349	DNA-binding transcription factor activity
OF158_RS11805	COG2244	polysaccharide biosynthetic process
OF158_RS11825	COG0495	leucyl-tRNA aminoacylation
OF158_RS11830	COG2814	Major facilitator Superfamily
OF158_RS11840	COG0275	rRNA processing
OF158_RS11850	COG2267	carboxylic ester hydrolase activity
OF158_RS11855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OF158_RS11860	COG0367	asparagine synthase
OF158_RS11865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OF158_RS11870	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
OF158_RS11880	COG1506	peptidase
OF158_RS11885	COG0655	NAD(P)H dehydrogenase (quinone) activity
OF158_RS11890	COG1070	Carbohydrate kinase
OF158_RS11895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OF158_RS11900	COG1116	anion transmembrane transporter activity
OF158_RS11905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OF158_RS11920	COG0783	Belongs to the Dps family
OF158_RS11925	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
OF158_RS11935	COG0803	Belongs to the bacterial solute-binding protein 9 family
OF158_RS11945	COG4948	Mandelate Racemase Muconate Lactonizing
OF158_RS11950	COG0318	PFAM AMP-dependent synthetase and ligase
OF158_RS11955	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OF158_RS11960	COG0596	Alpha beta hydrolase
OF158_RS11965	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
OF158_RS11970	COG1169	isochorismate synthase
OF158_RS11975	COG1575	Belongs to the MenA family. Type 1 subfamily
OF158_RS12100	COG1285	pathogenesis
OF158_RS12130	COG2217	Heavy metal translocating P-type atpase
OF158_RS12135	COG2608	mercury ion transmembrane transporter activity
OF158_RS12150	COG1522	sequence-specific DNA binding
OF158_RS12170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OF158_RS12190	COG0726	polysaccharide deacetylase
OF158_RS12220	COG0038	chloride channel
OF158_RS12230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OF158_RS12235	COG1937	Protein conserved in bacteria
OF158_RS12245	COG1525	nuclease
OF158_RS12250	COG2190	(PTS) system
OF158_RS12265	COG0235	Class ii aldolase
OF158_RS12270	COG2160	L-arabinose isomerase activity
OF158_RS12275	COG1609	Transcriptional regulator
OF158_RS12280	COG4213	ABC transporter substrate-binding protein
OF158_RS12290	COG4214	carbohydrate transport
OF158_RS12295	COG2160	L-arabinose isomerase activity
OF158_RS12305	COG1609	Transcriptional regulator
OF158_RS12310	COG0840	transmembrane signaling receptor activity
OF158_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS12330	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
OF158_RS12350	COG1012	belongs to the aldehyde dehydrogenase family
OF158_RS12375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
OF158_RS12385	COG2155	Conserved Protein
OF158_RS12400	COG1098	S1 RNA binding domain
OF158_RS12415	COG0656	L-ascorbic acid biosynthetic process
OF158_RS12435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OF158_RS12465	COG2814	Major facilitator Superfamily
OF158_RS12470	COG2050	protein possibly involved in aromatic compounds catabolism
OF158_RS12485	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
OF158_RS12495	COG0697	spore germination
OF158_RS12505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
OF158_RS12510	COG3584	3D domain protein
OF158_RS12520	COG1252	NADH dehydrogenase
OF158_RS12525	COG0492	ferredoxin-NADP+ reductase activity
OF158_RS12550	COG0316	Belongs to the HesB IscA family
OF158_RS12555	COG4837	Protein of unknown function (DUF1462)
OF158_RS12560	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
OF158_RS12565	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
OF158_RS12570	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OF158_RS12580	COG2445	Protein of unknown function DUF86
OF158_RS12585	COG4470	Protein conserved in bacteria
OF158_RS12595	COG0739	heme binding
OF158_RS12605	COG3377	Domain of unknown function (DUF1805)
OF158_RS12610	COG0737	Belongs to the 5'-nucleotidase family
OF158_RS12615	COG0719	Fe-S assembly protein
OF158_RS12620	COG0822	iron-sulfur transferase activity
OF158_RS12625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OF158_RS12630	COG0719	Fe-S assembly protein
OF158_RS12635	COG0396	ATPase activity
OF158_RS12645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF158_RS12650	COG0509	glycine decarboxylation via glycine cleavage system
OF158_RS12655	COG1393	Belongs to the ArsC family
OF158_RS12660	COG1960	acyl-CoA dehydrogenase activity
OF158_RS12665	COG0183	Belongs to the thiolase family
OF158_RS12670	COG1024	Enoyl-CoA hydratase
OF158_RS12670	COG1250	3-hydroxyacyl-CoA dehydrogenase
OF158_RS12685	COG5577	PFAM Coat F domain
OF158_RS12690	COG0772	Belongs to the SEDS family
OF158_RS12695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OF158_RS12710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
OF158_RS12715	COG2199	diguanylate cyclase activity
OF158_RS12715	COG2200	EAL domain
OF158_RS12715	COG2202	Pas domain
OF158_RS12720	COG0753	catalase activity
OF158_RS12725	COG0671	phosphoesterase, PA-phosphatase related
OF158_RS12735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OF158_RS12750	COG1595	DNA-templated transcription, initiation
OF158_RS12755	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OF158_RS12770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OF158_RS12780	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
OF158_RS12785	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS12790	COG2211	Major facilitator Superfamily
OF158_RS12795	COG1904	glucuronate isomerase
OF158_RS12800	COG2721	sulfolactate sulfo-lyase activity
OF158_RS12805	COG0246	Mannitol dehydrogenase
OF158_RS12815	COG0800	Aldolase
OF158_RS12820	COG1414	Transcriptional regulator
OF158_RS12885	COG0557	exoribonuclease II activity
OF158_RS12890	COG1647	Serine aminopeptidase, S33
OF158_RS12895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OF158_RS12905	COG0148	phosphopyruvate hydratase activity
OF158_RS12910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
OF158_RS12920	COG0126	phosphoglycerate kinase activity
OF158_RS12940	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
OF158_RS12960	COG3383	formate dehydrogenase (NAD+) activity
OF158_RS12970	COG0840	transmembrane signaling receptor activity
OF158_RS12995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OF158_RS13010	COG4608	Belongs to the ABC transporter superfamily
OF158_RS13015	COG0791	NLP P60 protein
OF158_RS13020	COG4166	transmembrane transport
OF158_RS13025	COG0444	Belongs to the ABC transporter superfamily
OF158_RS13030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OF158_RS13035	COG0601	transmembrane transport
OF158_RS13040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OF158_RS13045	COG0598	Magnesium transport protein CorA
OF158_RS13055	COG2719	SpoVR family
OF158_RS13060	COG3594	Acyltransferase
OF158_RS13085	COG1392	Phosphate transport regulator
OF158_RS13090	COG0306	phosphate transporter
OF158_RS13105	COG2718	Belongs to the UPF0229 family
OF158_RS13110	COG2766	serine protein kinase
OF158_RS13115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OF158_RS13130	COG2095	MarC family integral membrane protein
OF158_RS13140	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
OF158_RS13145	COG0596	Alpha beta hydrolase
OF158_RS13150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OF158_RS13155	COG0765	amino acid transport
OF158_RS13160	COG1126	abc transporter atp-binding protein
OF158_RS13165	COG2116	formate transmembrane transporter activity
OF158_RS13185	COG1882	Formate acetyltransferase
OF158_RS13190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OF158_RS13195	COG0431	NADPH-dependent FMN reductase
OF158_RS13210	COG1131	(ABC) transporter
OF158_RS13245	COG0745	RESPONSE REGULATOR receiver
OF158_RS13250	COG3850	Histidine kinase
OF158_RS13250	COG5002	protein histidine kinase activity
OF158_RS13260	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
OF158_RS13275	COG2188	Transcriptional regulator
OF158_RS13280	COG3104	oligopeptide transport
OF158_RS13285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OF158_RS13310	COG1846	Transcriptional regulator
OF158_RS13355	COG2271	Major facilitator Superfamily
OF158_RS13365	COG0697	spore germination
OF158_RS13380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OF158_RS13390	COG2323	membrane
OF158_RS13495	COG3527	Alpha-acetolactate decarboxylase
OF158_RS13500	COG0028	Belongs to the TPP enzyme family
OF158_RS13505	COG0583	DNA-binding transcription factor activity
OF158_RS13510	COG0735	belongs to the Fur family
OF158_RS13525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OF158_RS13530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OF158_RS13535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OF158_RS13540	COG1116	anion transmembrane transporter activity
OF158_RS13545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OF158_RS13550	COG2814	Major facilitator Superfamily
OF158_RS13565	COG4129	membrane
OF158_RS13570	COG1737	Transcriptional regulator
OF158_RS13575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OF158_RS13575	COG1263	PTS System
OF158_RS13580	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
OF158_RS13590	COG1132	(ABC) transporter
OF158_RS13595	COG3557	Belongs to the UPF0374 family
OF158_RS13610	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS13615	COG0583	DNA-binding transcription factor activity
OF158_RS13620	COG0067	glutamate synthase
OF158_RS13620	COG0069	glutamate synthase activity
OF158_RS13620	COG0070	glutamate synthase
OF158_RS13625	COG0493	'glutamate synthase
OF158_RS13650	COG1131	(ABC) transporter
OF158_RS13660	COG1988	membrane-bound metal-dependent
OF158_RS13665	COG1194	a g-specific adenine glycosylase
OF158_RS13700	COG0159	tryptophan synthase activity
OF158_RS13710	COG0133	tryptophan synthase activity
OF158_RS13715	COG0134	indole-3-glycerol-phosphate synthase activity
OF158_RS13720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OF158_RS13725	COG0512	Glutamine amidotransferase of anthranilate synthase
OF158_RS13725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OF158_RS13735	COG0577	efflux transmembrane transporter activity
OF158_RS13740	COG0577	efflux transmembrane transporter activity
OF158_RS13740	COG1136	(ABC) transporter
OF158_RS13745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OF158_RS13765	COG1131	(ABC) transporter
OF158_RS13800	COG2197	response regulator
OF158_RS13805	COG4585	Histidine kinase
OF158_RS13820	COG1012	belongs to the aldehyde dehydrogenase family
OF158_RS13820	COG1012	belongs to the aldehyde dehydrogenase family
OF158_RS13830	COG0058	SHG alpha-glucan phosphorylase activity
OF158_RS13835	COG0840	transmembrane signaling receptor activity
OF158_RS13840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OF158_RS13845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OF158_RS13850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
OF158_RS13865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OF158_RS13870	COG0066	3-isopropylmalate dehydratase activity
OF158_RS13875	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OF158_RS13885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OF158_RS13890	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OF158_RS13895	COG0440	acetolactate synthase activity
OF158_RS13900	COG0028	Belongs to the TPP enzyme family
OF158_RS13905	COG0129	dihydroxy-acid dehydratase activity
OF158_RS13910	COG1114	Component of the transport system for branched-chain amino acids
OF158_RS13915	COG1366	Belongs to the anti-sigma-factor antagonist family
OF158_RS13925	COG2124	cytochrome p450
OF158_RS13930	COG0670	Belongs to the BI1 family
OF158_RS13935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OF158_RS13940	COG2223	nitrite transmembrane transporter activity
OF158_RS13945	COG3279	Response regulator of the LytR AlgR family
OF158_RS13950	COG3275	phosphorelay sensor kinase activity
OF158_RS13955	COG0252	asparaginase activity
OF158_RS13960	COG2132	Multicopper oxidase
OF158_RS13965	COG1309	transcriptional regulator
OF158_RS13970	COG1511	domain protein
OF158_RS14005	COG0840	transmembrane signaling receptor activity
OF158_RS14005	COG5278	phosphoserine phosphatase activity
OF158_RS14010	COG3739	integral membrane protein
OF158_RS14015	COG3655	Transcriptional regulator
OF158_RS14030	COG1823	symporter activity
OF158_RS14035	COG2839	Protein conserved in bacteria
OF158_RS14055	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
OF158_RS14060	COG0477	Major facilitator Superfamily
OF158_RS14065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OF158_RS14070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OF158_RS14075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OF158_RS14080	COG0840	transmembrane signaling receptor activity
OF158_RS14095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OF158_RS14100	COG1132	(ABC) transporter
OF158_RS14105	COG1846	Transcriptional regulator
OF158_RS14115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OF158_RS14120	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
OF158_RS14140	COG0387	Pfam Sodium calcium exchanger
OF158_RS14145	COG0477	Major facilitator Superfamily
OF158_RS14150	COG1295	ribonuclease BN
OF158_RS14155	COG4840	Belongs to the UPF0435 family
OF158_RS14160	COG0024	Methionine aminopeptidase
OF158_RS14165	COG0693	protein deglycase activity
OF158_RS14170	COG1360	Flagellar Motor Protein
OF158_RS14175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
OF158_RS14190	COG3189	MarR family transcriptional regulator
OF158_RS14200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OF158_RS14205	COG1607	acyl-coa hydrolase
OF158_RS14210	COG1077	Cell shape determining protein MreB Mrl
OF158_RS14215	COG2268	Band 7 protein
OF158_RS14220	COG1585	Membrane protein implicated in regulation of membrane protease activity
OF158_RS14225	COG0626	cystathionine gamma-synthase activity
OF158_RS14230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OF158_RS14235	COG1854	S-ribosylhomocysteine lyase activity
OF158_RS14240	COG2226	methyltransferase
OF158_RS14245	COG0288	reversible hydration of carbon dioxide
OF158_RS14250	COG0860	N-Acetylmuramoyl-L-alanine amidase
OF158_RS14260	COG2197	response regulator
OF158_RS14280	COG4086	secreted protein
OF158_RS14285	COG0737	Belongs to the 5'-nucleotidase family
OF158_RS14305	COG3620	sequence-specific DNA binding
OF158_RS14310	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
OF158_RS14315	COG1518	maintenance of DNA repeat elements
OF158_RS14360	COG1304	FMN binding
OF158_RS14370	COG0166	Belongs to the GPI family
OF158_RS14375	COG0025	NhaP-type Na H and K H
OF158_RS14380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OF158_RS14380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OF158_RS14380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OF158_RS14385	COG1349	DNA-binding transcription factor activity
OF158_RS14390	COG0371	Dehydrogenase
OF158_RS14405	COG0561	phosphatase activity
OF158_RS14420	COG2814	Major facilitator Superfamily
OF158_RS14425	COG0820	rRNA (adenine-C2-)-methyltransferase activity
OF158_RS14440	COG2357	RelA SpoT domain protein
OF158_RS14445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
OF158_RS14450	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
OF158_RS14455	COG1461	Dihydroxyacetone kinase
OF158_RS14460	COG2376	Dihydroxyacetone kinase
OF158_RS14470	COG0778	Nitroreductase
OF158_RS14475	COG1113	amino acid transport
OF158_RS14480	COG0730	response to heat
OF158_RS14485	COG2233	PERMEase
OF158_RS14495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OF158_RS14510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OF158_RS14515	COG1024	Enoyl-CoA hydratase
OF158_RS14520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OF158_RS14525	COG0511	ligase activity, forming carbon-carbon bonds
OF158_RS14530	COG0439	Biotin carboxylase
OF158_RS14535	COG1960	acyl-CoA dehydrogenase activity
OF158_RS14540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OF158_RS14555	COG1349	DNA-binding transcription factor activity
OF158_RS14565	COG2376	Dihydroxyacetone kinase
OF158_RS14575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OF158_RS14585	COG2271	Major facilitator Superfamily
OF158_RS14595	COG1250	3-hydroxyacyl-CoA dehydrogenase
OF158_RS14605	COG0698	ribose 5-phosphate isomerase
OF158_RS14610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OF158_RS14615	COG1494	fructose-1,6-bisphosphatase
OF158_RS14620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OF158_RS14625	COG3829	transcription factor binding
OF158_RS14630	COG0833	amino acid
OF158_RS14665	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
OF158_RS14670	COG1140	nitrate reductase beta subunit
OF158_RS14680	COG2181	nitrate reductase activity
OF158_RS14685	COG2223	nitrite transmembrane transporter activity
OF158_RS14690	COG3588	fructose-bisphosphate aldolase
OF158_RS14705	COG4268	DNA restriction-modification system
OF158_RS14710	COG1401	restriction endodeoxyribonuclease activity
OF158_RS14715	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
OF158_RS14790	COG0583	DNA-binding transcription factor activity
OF158_RS14795	COG0431	NADPH-dependent FMN reductase
OF158_RS14800	COG0454	-acetyltransferase
OF158_RS14805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OF158_RS14815	COG0765	amino acid transport
OF158_RS14820	COG0765	amino acid transport
OF158_RS14825	COG1126	abc transporter atp-binding protein
OF158_RS14830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OF158_RS14835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OF158_RS14840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OF158_RS14850	COG0386	Belongs to the glutathione peroxidase family
OF158_RS14855	COG2190	(PTS) system
OF158_RS14870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OF158_RS14870	COG1263	PTS System
OF158_RS14875	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
OF158_RS14875	COG0517	IMP dehydrogenase activity
OF158_RS14890	COG0281	malic enzyme
OF158_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS14910	COG1301	dicarboxylic acid transport
OF158_RS14920	COG1328	CTP reductase activity
OF158_RS14930	COG1063	alcohol dehydrogenase
OF158_RS14935	COG3835	regulator
OF158_RS14940	COG1929	Belongs to the glycerate kinase type-1 family
OF158_RS14945	COG2610	gluconate transmembrane transporter activity
OF158_RS14950	COG1879	ABC-type sugar transport system periplasmic component
OF158_RS14955	COG1172	Belongs to the binding-protein-dependent transport system permease family
OF158_RS14960	COG1129	ABC transporter
OF158_RS14965	COG1869	D-ribose catabolic process
OF158_RS14970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OF158_RS14975	COG1609	Transcriptional regulator
OF158_RS15010	COG4549	nuclear export factor GLE1
OF158_RS15015	COG1276	copper resistance
OF158_RS15015	COG2372	response to copper ion
OF158_RS15025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OF158_RS15030	COG1609	Transcriptional regulator
OF158_RS15045	COG5002	protein histidine kinase activity
OF158_RS15050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OF158_RS15055	COG1278	Cold shock
OF158_RS15060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OF158_RS15080	COG0697	spore germination
OF158_RS15085	COG1472	Belongs to the glycosyl hydrolase 3 family
OF158_RS15100	COG3876	Protein conserved in bacteria
OF158_RS15120	COG1132	(ABC) transporter
OF158_RS15125	COG1132	(ABC) transporter
OF158_RS15145	COG1388	LysM domain
OF158_RS15145	COG0791	NLP P60 protein
OF158_RS15165	COG2272	Belongs to the type-B carboxylesterase lipase family
OF158_RS15170	COG0154	amidase activity
OF158_RS15175	COG2814	Major facilitator Superfamily
OF158_RS15225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
OF158_RS15225	COG3153	acetyltransferase
OF158_RS15230	COG5583	Uncharacterized small protein (DUF2292)
OF158_RS15235	COG0431	NADPH-dependent FMN reductase
OF158_RS15240	COG1116	anion transmembrane transporter activity
OF158_RS15245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OF158_RS15250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OF158_RS15255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OF158_RS15285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OF158_RS15300	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
OF158_RS15310	COG2390	Transcriptional regulator
OF158_RS15320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
OF158_RS15330	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
OF158_RS15345	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OF158_RS15350	COG1984	allophanate hydrolase subunit 2
OF158_RS15355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OF158_RS15360	COG2814	Major facilitator Superfamily
OF158_RS15365	COG1764	response to oxidative stress
OF158_RS15370	COG1126	abc transporter atp-binding protein
OF158_RS15375	COG0765	amino acid transport
OF158_RS15380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OF158_RS15390	COG0326	Molecular chaperone. Has ATPase activity
OF158_RS15455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OF158_RS15470	COG1064	alcohol dehydrogenase
OF158_RS15495	COG2814	Major facilitator Superfamily
OF158_RS15500	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS15540	COG3716	PTS system mannose fructose sorbose family IID component
OF158_RS15625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OF158_RS15630	COG1597	lipid kinase activity
OF158_RS15655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OF158_RS15660	COG0154	amidase activity
OF158_RS15665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OF158_RS15670	COG2224	Isocitrate lyase
OF158_RS15675	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
OF158_RS15680	COG4851	CamS sex pheromone cAM373 precursor
OF158_RS15700	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
OF158_RS15705	COG4496	protein, YerC YecD
OF158_RS15710	COG1470	cell adhesion involved in biofilm formation
OF158_RS15725	COG0151	Belongs to the GarS family
OF158_RS15730	COG0138	bifunctional purine biosynthesis protein purh
OF158_RS15735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OF158_RS15740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OF158_RS15745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
OF158_RS15750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OF158_RS15755	COG0047	phosphoribosylformylglycinamidine synthase activity
OF158_RS15760	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OF158_RS15770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OF158_RS15775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OF158_RS15780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OF158_RS15790	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
OF158_RS15795	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
OF158_RS15800	COG1263	PTS System
OF158_RS15800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OF158_RS15800	COG2190	(PTS) system
OF158_RS15815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OF158_RS15815	COG1263	PTS System
OF158_RS15845	COG1301	dicarboxylic acid transport
OF158_RS15855	COG3711	transcriptional antiterminator
OF158_RS15860	COG2252	PERMEase
OF158_RS15870	COG1132	(ABC) transporter
OF158_RS15875	COG2814	Major facilitator Superfamily
OF158_RS15880	COG2197	response regulator
OF158_RS15885	COG3850	Histidine kinase
OF158_RS15890	COG1131	(ABC) transporter
OF158_RS15900	COG0842	Transport permease protein
OF158_RS15915	COG0179	Fumarylacetoacetate (FAA) hydrolase
OF158_RS15940	COG0824	Thioesterase
OF158_RS15945	COG0318	PFAM AMP-dependent synthetase and ligase
OF158_RS15950	COG0183	Belongs to the thiolase family
OF158_RS15960	COG1250	3-hydroxyacyl-CoA dehydrogenase
OF158_RS15965	COG2508	Transcriptional regulator
OF158_RS15970	COG2814	Major facilitator Superfamily
OF158_RS15980	COG0179	Fumarylacetoacetate (FAA) hydrolase
OF158_RS15990	COG0471	metal ion transport
OF158_RS16015	COG1131	(ABC) transporter
OF158_RS16020	COG1725	Transcriptional regulator
OF158_RS16025	COG1695	Transcriptional regulator
OF158_RS16030	COG3479	Phenolic acid decarboxylase
OF158_RS16035	COG2910	NAD(P)H-binding
OF158_RS16040	COG1959	2 iron, 2 sulfur cluster binding
OF158_RS16070	COG0425	Belongs to the sulfur carrier protein TusA family
OF158_RS16075	COG2391	methyltransferase activity
OF158_RS16085	COG1028	Short-chain dehydrogenase reductase Sdr
OF158_RS16105	COG1120	ATPase activity
OF158_RS16110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OF158_RS16130	COG3620	sequence-specific DNA binding
OF158_RS16145	COG0519	Catalyzes the synthesis of GMP from XMP
OF158_RS16145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OF158_RS16150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OF158_RS16155	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
OF158_RS16160	COG1335	isochorismatase
OF158_RS16165	COG4948	Mandelate Racemase Muconate Lactonizing
OF158_RS16175	COG0463	Glycosyl transferase, family 2
OF158_RS16180	COG2246	polysaccharide biosynthetic process
OF158_RS16185	COG0459	protein refolding
OF158_RS16190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OF158_RS16195	COG1266	CAAX protease self-immunity
OF158_RS16205	COG0805	protein transport
OF158_RS16210	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
OF158_RS16215	COG0488	(ABC) transporter
OF158_RS16225	COG0456	acetyltransferase
OF158_RS16230	COG1214	PFAM Peptidase M22, glycoprotease
OF158_RS16235	COG0802	atpase or kinase
OF158_RS16320	COG3091	SprT-like family
OF158_RS16330	COG2183	response to ionizing radiation
OF158_RS16335	COG2208	phosphoserine phosphatase activity
OF158_RS16340	COG1191	sigma factor activity
OF158_RS16345	COG2172	sigma factor antagonist activity
OF158_RS16350	COG1366	Belongs to the anti-sigma-factor antagonist family
OF158_RS16355	COG2208	phosphoserine phosphatase activity
OF158_RS16360	COG2172	sigma factor antagonist activity
OF158_RS16365	COG1366	Belongs to the anti-sigma-factor antagonist family
OF158_RS16370	COG1366	Belongs to the anti-sigma-factor antagonist family
OF158_RS16375	COG2337	Toxic component of a toxin-antitoxin (TA) module
OF158_RS16380	COG0864	Transcriptional regulator
OF158_RS16390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
OF158_RS16395	COG0736	holo-[acyl-carrier-protein] synthase activity
OF158_RS16400	COG0705	Rhomboid family
OF158_RS16405	COG0513	Belongs to the DEAD box helicase family
OF158_RS16415	COG1280	lysine exporter protein (LysE YggA)
OF158_RS16420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OF158_RS16425	COG1609	Transcriptional regulator
OF158_RS16430	COG0366	Alpha amylase catalytic
OF158_RS16440	COG2182	Extracellular solute-binding protein
OF158_RS16460	COG3833	ABC-type maltose transport systems, permease component
OF158_RS16470	COG1554	hydrolase, family 65, central catalytic
OF158_RS16480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OF158_RS16485	COG1181	Belongs to the D-alanine--D-alanine ligase family
OF158_RS16495	COG1253	flavin adenine dinucleotide binding
OF158_RS16500	COG0789	Transcriptional regulator
OF158_RS16505	COG1253	flavin adenine dinucleotide binding
OF158_RS16525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
OF158_RS16540	COG0629	single-stranded DNA binding
OF158_RS16550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OF158_RS16555	COG4786	Flagellar basal body rod
OF158_RS16560	COG4786	Flagellar basal body rod
OF158_RS16565	COG1077	Cell shape determining protein MreB Mrl
OF158_RS16570	COG1609	Transcriptional regulator
OF158_RS16575	COG0739	heme binding
OF158_RS16580	COG2385	sporulation resulting in formation of a cellular spore
OF158_RS16585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OF158_RS16595	COG4836	Membrane
OF158_RS16600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OF158_RS16605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OF158_RS16610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OF158_RS16615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OF158_RS16620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OF158_RS16630	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OF158_RS16635	COG0356	it plays a direct role in the translocation of protons across the membrane
OF158_RS16645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OF158_RS16650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OF158_RS16660	COG0698	ribose 5-phosphate isomerase
OF158_RS16675	COG1971	Probably functions as a manganese efflux pump
OF158_RS16680	COG0009	L-threonylcarbamoyladenylate synthase
OF158_RS16695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OF158_RS16705	COG1435	thymidine kinase activity
OF158_RS16710	COG0254	rRNA binding
OF158_RS16715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OF158_RS16720	COG1494	fructose-1,6-bisphosphatase
OF158_RS16725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OF158_RS16730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OF158_RS16735	COG0191	fructose-bisphosphate aldolase activity
OF158_RS16740	COG2204	response regulator
OF158_RS16755	COG1131	(ABC) transporter
OF158_RS16760	COG1725	Transcriptional regulator
OF158_RS16765	COG0504	CTP synthase activity
OF158_RS16770	COG3343	RNA polymerase activity
OF158_RS16775	COG1136	(ABC) transporter
OF158_RS16785	COG1703	isobutyryl-CoA mutase activity
OF158_RS16785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OF158_RS16785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OF158_RS16790	COG1309	transcriptional regulator
OF158_RS16795	COG1960	acyl-CoA dehydrogenase activity
OF158_RS16800	COG1960	acyl-CoA dehydrogenase activity
OF158_RS16805	COG0183	Belongs to the thiolase family
OF158_RS16810	COG0247	lactate metabolic process
OF158_RS16810	COG2181	nitrate reductase activity
OF158_RS16815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OF158_RS16820	COG0018	arginyl-trna synthetase
OF158_RS16830	COG0010	Belongs to the arginase family
OF158_RS16835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OF158_RS16845	COG1994	Peptidase M50
OF158_RS16855	COG3465	dGTPase activity
OF158_RS16860	COG1078	dGTPase activity
OF158_RS16875	COG0095	Lipoate-protein ligase
OF158_RS16880	COG0280	phosphate acetyltransferase
OF158_RS16885	COG3253	May function as heme-dependent peroxidase
OF158_RS16895	COG2363	Small membrane protein
OF158_RS16905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
OF158_RS16935	COG4555	ABC transporter
OF158_RS16945	COG1121	(ABC) transporter
OF158_RS16955	COG0351	phosphomethylpyrimidine kinase
OF158_RS16970	COG0561	phosphatase activity
OF158_RS16975	COG0514	ATP-dependent DNA helicase (RecQ)
OF158_RS16980	COG1785	Belongs to the alkaline phosphatase family
OF158_RS16985	COG1737	Transcriptional regulator
OF158_RS17000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OF158_RS17010	COG1346	cytolysis
OF158_RS17015	COG1380	Effector of murein hydrolase LrgA
OF158_RS17020	COG0583	DNA-binding transcription factor activity
OF158_RS17025	COG0367	asparagine synthase
OF158_RS17045	COG2966	Psort location CytoplasmicMembrane, score
OF158_RS17050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OF158_RS17055	COG1966	Carbon starvation protein
OF158_RS17065	COG3275	phosphorelay sensor kinase activity
OF158_RS17070	COG1464	Belongs to the NlpA lipoprotein family
OF158_RS17075	COG2011	ABC-type metal ion transport system permease component
OF158_RS17080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OF158_RS17085	COG1119	ATPase activity
OF158_RS17100	COG0534	Mate efflux family protein
OF158_RS17105	COG1442	glycosyl transferase family 8
OF158_RS17110	COG2195	Cleaves the N-terminal amino acid of tripeptides
OF158_RS17115	COG2814	Major facilitator Superfamily
OF158_RS17125	COG0028	Belongs to the TPP enzyme family
OF158_RS17130	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
OF158_RS17140	COG1132	(ABC) transporter
OF158_RS17150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OF158_RS17170	COG2188	Transcriptional regulator
OF158_RS17175	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
OF158_RS17180	COG1366	Belongs to the anti-sigma-factor antagonist family
OF158_RS17185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OF158_RS17190	COG0765	amino acid transport
OF158_RS17195	COG1126	abc transporter atp-binding protein
OF158_RS17215	COG3457	Alanine racemase
OF158_RS17225	COG1126	abc transporter atp-binding protein
OF158_RS17235	COG0765	amino acid transport
OF158_RS17245	COG0579	oxidoreductase
OF158_RS17250	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
OF158_RS17255	COG0732	type I restriction modification DNA specificity domain
OF158_RS17335	COG1280	lysine exporter protein (LysE YggA)
OF158_RS17345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OF158_RS17370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
OF158_RS17375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OF158_RS17380	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
OF158_RS17385	COG4853	Protein conserved in bacteria
OF158_RS17390	COG4863	YycH protein
OF158_RS17395	COG5002	protein histidine kinase activity
OF158_RS17400	COG0745	RESPONSE REGULATOR receiver
OF158_RS17415	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OF158_RS17420	COG0305	Participates in initiation and elongation during chromosome replication
OF158_RS17425	COG0359	binds to the 23S rRNA
OF158_RS17430	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
OF158_RS17440	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OF158_RS17450	COG0360	Binds together with S18 to 16S ribosomal RNA
OF158_RS17455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
OF158_RS17460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OF158_RS17460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OF158_RS17465	COG0307	riboflavin synthase, alpha
OF158_RS17470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OF158_RS17470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OF158_RS17475	COG0012	GTP binding
OF158_RS17480	COG4481	Protein conserved in bacteria
OF158_RS17485	COG0668	transmembrane transport
OF158_RS17500	COG1475	DNA binding
OF158_RS17505	COG1192	Involved in chromosome partitioning
OF158_RS17510	COG1475	DNA binding
OF158_RS17515	COG0357	Ribosomal RNA small subunit methyltransferase G
OF158_RS17520	COG0445	tRNA wobble uridine modification
OF158_RS17525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OF158_RS17530	COG1847	R3H domain protein
OF158_RS17535	COG0706	membrane insertase activity
OF158_RS17540	COG0594	ribonuclease P activity
OF158_RS17545	COG0230	Belongs to the bacterial ribosomal protein bL34 family