locus-tag	class	description
AXE80_RS00010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AXE80_RS00015	COG0436	Aminotransferase
AXE80_RS00020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AXE80_RS00030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AXE80_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AXE80_RS00055	COG3119	arylsulfatase activity
AXE80_RS00060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXE80_RS00070	COG0513	Belongs to the DEAD box helicase family
AXE80_RS00085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AXE80_RS00095	COG0358	DNA primase activity
AXE80_RS00120	COG2884	Cell division ATP-binding protein ftsE
AXE80_RS00135	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AXE80_RS00150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AXE80_RS00160	COG0590	tRNA wobble adenosine to inosine editing
AXE80_RS00170	COG0584	glycerophosphoryl diester phosphodiesterase
AXE80_RS00180	COG1528	Iron-storage protein
AXE80_RS00185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AXE80_RS00190	COG1970	mechanosensitive ion channel activity
AXE80_RS00195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AXE80_RS00200	COG1435	thymidine kinase activity
AXE80_RS00235	COG1040	competence protein
AXE80_RS00245	COG0423	glycine-tRNA ligase activity
AXE80_RS00250	COG0798	PFAM Bile acid sodium symporter
AXE80_RS00270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AXE80_RS00280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AXE80_RS00290	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AXE80_RS00305	COG0564	pseudouridine synthase activity
AXE80_RS00310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AXE80_RS00320	COG2001	Belongs to the MraZ family
AXE80_RS00325	COG0275	rRNA processing
AXE80_RS00340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AXE80_RS00345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXE80_RS00350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AXE80_RS00355	COG0772	Belongs to the SEDS family
AXE80_RS00360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AXE80_RS00365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXE80_RS00385	COG1610	YqeY-like protein
AXE80_RS00390	COG1607	acyl-coa hydrolase
AXE80_RS00400	COG1609	Transcriptional regulator
AXE80_RS00405	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AXE80_RS00405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AXE80_RS00420	COG0488	(ABC) transporter
AXE80_RS00430	COG1705	Flagellar rod assembly protein muramidase FlgJ
AXE80_RS00445	COG1032	radical SAM domain protein
AXE80_RS00450	COG3119	arylsulfatase activity
AXE80_RS00455	COG0668	transmembrane transport
AXE80_RS00460	COG3119	arylsulfatase activity
AXE80_RS00470	COG0137	argininosuccinate synthase activity
AXE80_RS00475	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AXE80_RS00480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXE80_RS00505	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AXE80_RS00515	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AXE80_RS00525	COG0165	Argininosuccinate lyase
AXE80_RS00555	COG1881	PFAM PEBP family protein
AXE80_RS00560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXE80_RS00575	COG0339	signal peptide processing
AXE80_RS00580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AXE80_RS00585	COG0512	Glutamine amidotransferase of anthranilate synthase
AXE80_RS00590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AXE80_RS00595	COG0134	indole-3-glycerol-phosphate synthase activity
AXE80_RS00600	COG0135	phosphoribosylanthranilate isomerase activity
AXE80_RS00605	COG0133	tryptophan synthase activity
AXE80_RS00610	COG0159	tryptophan synthase activity
AXE80_RS00615	COG0288	reversible hydration of carbon dioxide
AXE80_RS00635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AXE80_RS00640	COG0196	riboflavin kinase activity
AXE80_RS00650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AXE80_RS00660	COG0156	8-amino-7-oxononanoate synthase activity
AXE80_RS00665	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AXE80_RS00670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AXE80_RS00680	COG0628	permease
AXE80_RS00685	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AXE80_RS00705	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
AXE80_RS00710	COG1702	phosphate starvation-inducible protein PhoH
AXE80_RS00715	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AXE80_RS00725	COG3220	belongs to the UPF0276 family
AXE80_RS00750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AXE80_RS00750	COG3153	acetyltransferase
AXE80_RS00755	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AXE80_RS00770	COG0357	Ribosomal RNA small subunit methyltransferase G
AXE80_RS00780	COG0436	Aminotransferase
AXE80_RS00800	COG1214	PFAM Peptidase M22, glycoprotease
AXE80_RS00830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AXE80_RS00835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AXE80_RS00840	COG0297	glycogen (starch) synthase activity
AXE80_RS00845	COG0481	GTPase activity
AXE80_RS00855	COG0495	leucyl-tRNA aminoacylation
AXE80_RS00860	COG5000	phosphorelay sensor kinase activity
AXE80_RS00870	COG1024	Enoyl-CoA hydratase
AXE80_RS00880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AXE80_RS00885	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AXE80_RS00890	COG0440	acetolactate synthase activity
AXE80_RS00895	COG0028	Belongs to the TPP enzyme family
AXE80_RS00900	COG0129	dihydroxy-acid dehydratase activity
AXE80_RS00910	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AXE80_RS00915	COG0191	fructose-bisphosphate aldolase activity
AXE80_RS00925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXE80_RS00935	COG2226	methyltransferase
AXE80_RS00940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AXE80_RS00955	COG0442	prolyl-tRNA aminoacylation
AXE80_RS00965	COG0268	Binds directly to 16S ribosomal RNA
AXE80_RS00975	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AXE80_RS00980	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AXE80_RS00990	COG0848	biopolymer transport protein
AXE80_RS01000	COG0285	dihydrofolate synthase activity
AXE80_RS01030	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AXE80_RS01040	COG1482	cell wall glycoprotein biosynthetic process
AXE80_RS01045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AXE80_RS01050	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AXE80_RS01075	COG2244	polysaccharide biosynthetic process
AXE80_RS01120	COG2244	polysaccharide biosynthetic process
AXE80_RS01130	COG0438	transferase activity, transferring glycosyl groups
AXE80_RS01145	COG3206	protein involved in exopolysaccharide biosynthesis
AXE80_RS01145	COG0489	protein tyrosine kinase activity
AXE80_RS01155	COG1605	Chorismate mutase
AXE80_RS01155	COG0077	Prephenate dehydratase
AXE80_RS01165	COG0287	Prephenate dehydrogenase
AXE80_RS01170	COG1605	Chorismate mutase
AXE80_RS01170	COG0287	Prephenate dehydrogenase
AXE80_RS01175	COG1162	GTPase activity
AXE80_RS01180	COG1490	D-aminoacyl-tRNA deacylase activity
AXE80_RS01195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AXE80_RS01200	COG0321	lipoyl(octanoyl) transferase activity
AXE80_RS01205	COG1131	(ABC) transporter
AXE80_RS01225	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AXE80_RS01230	COG0561	phosphatase activity
AXE80_RS01235	COG0326	Molecular chaperone. Has ATPase activity
AXE80_RS01245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AXE80_RS01255	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AXE80_RS01265	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AXE80_RS01270	COG2086	electron transfer activity
AXE80_RS01275	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXE80_RS01275	COG0022	dehydrogenase e1 component
AXE80_RS01285	COG1227	inorganic diphosphatase activity
AXE80_RS01290	COG1428	Deoxynucleoside kinase
AXE80_RS01300	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AXE80_RS01300	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AXE80_RS01300	COG0506	proline dehydrogenase activity
AXE80_RS01305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AXE80_RS01315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AXE80_RS01320	COG0527	aspartate kinase activity
AXE80_RS01320	COG0460	homoserine dehydrogenase
AXE80_RS01330	COG0300	oxidoreductase activity
AXE80_RS01340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AXE80_RS01345	COG0598	Magnesium transport protein CorA
AXE80_RS01350	COG1196	nuclear chromosome segregation
AXE80_RS01350	COG3264	Mechanosensitive ion channel
AXE80_RS01355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AXE80_RS01360	COG0521	Mo-molybdopterin cofactor biosynthetic process
AXE80_RS01360	COG0315	cyclic pyranopterin monophosphate synthase activity
AXE80_RS01380	COG0746	molybdenum cofactor guanylyltransferase activity
AXE80_RS01385	COG0303	'Molybdopterin
AXE80_RS01390	COG1773	rubredoxin
AXE80_RS01395	COG0243	molybdopterin cofactor binding
AXE80_RS01405	COG0437	4 iron, 4 sulfur cluster binding
AXE80_RS01420	COG0243	molybdopterin cofactor binding
AXE80_RS01435	COG1017	nitric oxide dioxygenase activity
AXE80_RS01435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AXE80_RS01460	COG1116	anion transmembrane transporter activity
AXE80_RS01465	COG1116	anion transmembrane transporter activity
AXE80_RS01470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AXE80_RS01475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AXE80_RS01475	COG1116	anion transmembrane transporter activity
AXE80_RS01485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXE80_RS01490	COG2146	nitrite reductase [NAD(P)H] activity
AXE80_RS01490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXE80_RS01495	COG1959	2 iron, 2 sulfur cluster binding
AXE80_RS01515	COG0175	sulfate reduction
AXE80_RS01520	COG2895	sulfate adenylyltransferase (ATP) activity
AXE80_RS01525	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXE80_RS01535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AXE80_RS01535	COG1648	precorrin-2 dehydrogenase activity
AXE80_RS01540	COG0492	ferredoxin-NADP+ reductase activity
AXE80_RS01550	COG0633	Ferredoxin
AXE80_RS01565	COG1595	DNA-templated transcription, initiation
AXE80_RS01575	COG3250	beta-galactosidase activity
AXE80_RS01590	COG4771	TonB-dependent receptor
AXE80_RS01595	COG0561	phosphatase activity
AXE80_RS01620	COG1063	alcohol dehydrogenase
AXE80_RS01625	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE80_RS01630	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_RS01635	COG3119	arylsulfatase activity
AXE80_RS01640	COG1012	belongs to the aldehyde dehydrogenase family
AXE80_RS01645	COG3119	arylsulfatase activity
AXE80_RS01650	COG4948	Mandelate Racemase Muconate Lactonizing
AXE80_RS01655	COG2017	converts alpha-aldose to the beta-anomer
AXE80_RS01680	COG0284	orotidine-5'-phosphate decarboxylase activity
AXE80_RS01685	COG0772	Belongs to the SEDS family
AXE80_RS01690	COG0768	penicillin binding
AXE80_RS01705	COG1077	Cell shape determining protein MreB Mrl
AXE80_RS01710	COG0138	bifunctional purine biosynthesis protein purh
AXE80_RS01735	COG2239	Acts as a magnesium transporter
AXE80_RS01740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AXE80_RS01750	COG2322	membrane
AXE80_RS01755	COG1999	signal sequence binding
AXE80_RS01770	COG1845	cytochrome c oxidase, subunit III
AXE80_RS01775	COG1845	cytochrome c oxidase, subunit III
AXE80_RS01780	COG0109	protoheme IX farnesyltransferase activity
AXE80_RS01795	COG0492	ferredoxin-NADP+ reductase activity
AXE80_RS01810	COG0564	pseudouridine synthase activity
AXE80_RS01815	COG2824	Alkylphosphonate utilization operon protein PhnA
AXE80_RS01820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXE80_RS01845	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AXE80_RS01855	COG0826	peptidase U32
AXE80_RS01865	COG0788	formyltetrahydrofolate deformylase activity
AXE80_RS01870	COG0179	Fumarylacetoacetate (FAA) hydrolase
AXE80_RS01875	COG1546	Belongs to the CinA family
AXE80_RS01875	COG1058	Belongs to the CinA family
AXE80_RS01880	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXE80_RS01885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXE80_RS01895	COG0552	protein localization to endoplasmic reticulum
AXE80_RS01900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXE80_RS01955	COG0567	Dehydrogenase, E1 component
AXE80_RS01985	COG2255	four-way junction helicase activity
AXE80_RS02000	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AXE80_RS02010	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AXE80_RS02015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AXE80_RS02020	COG0616	signal peptide processing
AXE80_RS02025	COG1234	tRNA 3'-trailer cleavage
AXE80_RS02035	COG0540	Belongs to the ATCase OTCase family
AXE80_RS02040	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AXE80_RS02060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AXE80_RS02095	COG0681	Belongs to the peptidase S26 family
AXE80_RS02100	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AXE80_RS02110	COG1475	DNA binding
AXE80_RS02115	COG1192	Involved in chromosome partitioning
AXE80_RS02120	COG2195	Cleaves the N-terminal amino acid of tripeptides
AXE80_RS02125	COG0778	Nitroreductase
AXE80_RS02135	COG0022	dehydrogenase e1 component
AXE80_RS02145	COG1611	Belongs to the LOG family
AXE80_RS02165	COG2827	Endonuclease containing a URI domain
AXE80_RS02195	COG2205	protein histidine kinase activity
AXE80_RS02195	COG0784	Response regulator, receiver
AXE80_RS02200	COG2183	response to ionizing radiation
AXE80_RS02205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AXE80_RS02210	COG1115	amino acid carrier protein
AXE80_RS02220	COG1960	acyl-CoA dehydrogenase activity
AXE80_RS02225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AXE80_RS02230	COG4974	Belongs to the 'phage' integrase family
AXE80_RS02280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AXE80_RS02285	COG0081	regulation of translation
AXE80_RS02290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AXE80_RS02295	COG0222	ribosome binding
AXE80_RS02300	COG0085	RNA polymerase activity
AXE80_RS02305	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AXE80_RS02320	COG0706	membrane insertase activity
AXE80_RS02325	COG0504	CTP synthase activity
AXE80_RS02330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AXE80_RS02350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AXE80_RS02350	COG0551	DNA topoisomerase type I activity
AXE80_RS02375	COG4335	DNA alkylation repair
AXE80_RS02405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AXE80_RS02405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXE80_RS02430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AXE80_RS02440	COG0167	dihydroorotate dehydrogenase activity
AXE80_RS02460	COG0657	acetylesterase activity
AXE80_RS02460	COG2755	lipolytic protein G-D-S-L family
AXE80_RS02465	COG0305	Participates in initiation and elongation during chromosome replication
AXE80_RS02470	COG0561	phosphatase activity
AXE80_RS02475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXE80_RS02480	COG0501	Belongs to the peptidase M48B family
AXE80_RS02485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXE80_RS02495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AXE80_RS02510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXE80_RS02515	COG1609	Transcriptional regulator
AXE80_RS02525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AXE80_RS02535	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AXE80_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_RS02545	COG1940	carbohydrate kinase activity
AXE80_RS02550	COG3959	Transketolase, thiamine diphosphate binding domain
AXE80_RS02565	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AXE80_RS02590	COG1253	flavin adenine dinucleotide binding
AXE80_RS02595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXE80_RS02600	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AXE80_RS02610	COG1187	pseudouridine synthase activity
AXE80_RS02615	COG1285	pathogenesis
AXE80_RS02635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXE80_RS02645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AXE80_RS02650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXE80_RS02650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXE80_RS02670	COG0688	phosphatidylethanolamine metabolic process
AXE80_RS02675	COG4589	Belongs to the CDS family
AXE80_RS02685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AXE80_RS02705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AXE80_RS02710	COG0494	nUDIX hydrolase
AXE80_RS02730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AXE80_RS02735	COG0463	Glycosyl transferase, family 2
AXE80_RS02745	COG0539	negative regulation of cytoplasmic translation
AXE80_RS02760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AXE80_RS02765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AXE80_RS02805	COG0360	Binds together with S18 to 16S ribosomal RNA
AXE80_RS02810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AXE80_RS02815	COG0359	binds to the 23S rRNA
AXE80_RS02860	COG0686	Belongs to the AlaDH PNT family
AXE80_RS02865	COG0802	atpase or kinase
AXE80_RS02890	COG3119	arylsulfatase activity
AXE80_RS02895	COG0745	RESPONSE REGULATOR receiver
AXE80_RS02895	COG2205	protein histidine kinase activity
AXE80_RS02895	COG3292	Two component regulator propeller
AXE80_RS02935	COG3119	arylsulfatase activity
AXE80_RS02950	COG4771	TonB-dependent receptor
AXE80_RS02955	COG0702	epimerase
AXE80_RS02965	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AXE80_RS02975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AXE80_RS02985	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AXE80_RS03000	COG0280	phosphate acetyltransferase
AXE80_RS03000	COG0857	belongs to the CobB CobQ family
AXE80_RS03005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AXE80_RS03015	COG1253	flavin adenine dinucleotide binding
AXE80_RS03020	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AXE80_RS03025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AXE80_RS03030	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AXE80_RS03035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AXE80_RS03040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXE80_RS03040	COG0519	Catalyzes the synthesis of GMP from XMP
AXE80_RS03045	COG1388	LysM domain
AXE80_RS03045	COG3942	CHAP domain
AXE80_RS03055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AXE80_RS03060	COG1418	mRNA catabolic process
AXE80_RS03065	COG1999	signal sequence binding
AXE80_RS03070	COG0750	zinc metalloprotease
AXE80_RS03080	COG0228	four-way junction DNA binding
AXE80_RS03085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AXE80_RS03090	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AXE80_RS03095	COG2363	Small membrane protein
AXE80_RS03105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AXE80_RS03110	COG1216	Glycosyl transferase, family 2
AXE80_RS03145	COG0124	histidyl-tRNA synthetase
AXE80_RS03150	COG0302	gtp cyclohydrolase
AXE80_RS03155	COG3292	Two component regulator propeller
AXE80_RS03155	COG2205	protein histidine kinase activity
AXE80_RS03155	COG0745	RESPONSE REGULATOR receiver
AXE80_RS03160	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AXE80_RS03170	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE80_RS03175	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AXE80_RS03185	COG2814	Major facilitator Superfamily
AXE80_RS03205	COG1082	Xylose isomerase domain protein TIM barrel
AXE80_RS03210	COG3119	arylsulfatase activity
AXE80_RS03255	COG3119	arylsulfatase activity
AXE80_RS03265	COG3119	arylsulfatase activity
AXE80_RS03275	COG3119	arylsulfatase activity
AXE80_RS03310	COG3119	arylsulfatase activity
AXE80_RS03320	COG3119	arylsulfatase activity
AXE80_RS03325	COG3119	arylsulfatase activity
AXE80_RS03330	COG3119	arylsulfatase activity
AXE80_RS03335	COG3119	arylsulfatase activity
AXE80_RS03355	COG3119	arylsulfatase activity
AXE80_RS03370	COG3119	arylsulfatase activity
AXE80_RS03395	COG3119	arylsulfatase activity
AXE80_RS03410	COG1501	Belongs to the glycosyl hydrolase 31 family
AXE80_RS03415	COG3408	Glycogen debranching enzyme
AXE80_RS03415	COG3119	arylsulfatase activity
AXE80_RS03440	COG3507	Belongs to the glycosyl hydrolase 43 family
AXE80_RS03465	COG4771	TonB-dependent receptor
AXE80_RS03470	COG0561	phosphatase activity
AXE80_RS03490	COG3119	arylsulfatase activity
AXE80_RS03510	COG3119	arylsulfatase activity
AXE80_RS03520	COG3119	arylsulfatase activity
AXE80_RS03535	COG4771	TonB-dependent receptor
AXE80_RS03555	COG1629	transport
AXE80_RS03565	COG3119	arylsulfatase activity
AXE80_RS03565	COG3408	Glycogen debranching enzyme
AXE80_RS03580	COG3507	Belongs to the glycosyl hydrolase 43 family
AXE80_RS03625	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AXE80_RS03630	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_RS03635	COG4677	pectinesterase activity
AXE80_RS03645	COG0010	Belongs to the arginase family
AXE80_RS03650	COG1166	arginine decarboxylase activity
AXE80_RS03665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AXE80_RS03675	COG0004	ammonium transporteR
AXE80_RS03680	COG0347	Belongs to the P(II) protein family
AXE80_RS03685	COG0347	Belongs to the P(II) protein family
AXE80_RS03690	COG0004	ammonium transporteR
AXE80_RS03695	COG0347	Belongs to the P(II) protein family
AXE80_RS03715	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXE80_RS03725	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AXE80_RS03730	COG1127	ABC transporter
AXE80_RS03750	COG3250	beta-galactosidase activity
AXE80_RS03760	COG3408	Glycogen debranching enzyme
AXE80_RS03760	COG3119	arylsulfatase activity
AXE80_RS03765	COG3250	beta-galactosidase activity
AXE80_RS03770	COG0745	RESPONSE REGULATOR receiver
AXE80_RS03770	COG2205	protein histidine kinase activity
AXE80_RS03770	COG3292	Two component regulator propeller
AXE80_RS03775	COG3119	arylsulfatase activity
AXE80_RS03785	COG4771	TonB-dependent receptor
AXE80_RS03795	COG1629	transport
AXE80_RS03800	COG0702	epimerase
AXE80_RS03820	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_RS03835	COG0254	rRNA binding
AXE80_RS03840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AXE80_RS03850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AXE80_RS03860	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AXE80_RS03870	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXE80_RS03875	COG0658	competence protein
AXE80_RS03875	COG2333	competence protein COMEC
AXE80_RS03880	COG4232	protein-disulfide reductase activity
AXE80_RS03920	COG1169	isochorismate synthase
AXE80_RS03935	COG1595	DNA-templated transcription, initiation
AXE80_RS03945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AXE80_RS03945	COG0321	lipoyl(octanoyl) transferase activity
AXE80_RS03960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AXE80_RS03965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AXE80_RS03975	COG0045	succinate-CoA ligase (ADP-forming) activity
AXE80_RS03980	COG0045	succinate-CoA ligase (ADP-forming) activity
AXE80_RS03995	COG1132	(ABC) transporter
AXE80_RS04000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXE80_RS04015	COG0237	dephospho-CoA kinase activity
AXE80_RS04025	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AXE80_RS04030	COG0602	queuosine metabolic process
AXE80_RS04040	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE80_RS04045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AXE80_RS04050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AXE80_RS04055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXE80_RS04085	COG0482	sulfurtransferase activity
AXE80_RS04115	COG2814	Major facilitator Superfamily
AXE80_RS04125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXE80_RS04130	COG0577	efflux transmembrane transporter activity
AXE80_RS04130	COG1136	(ABC) transporter
AXE80_RS04135	COG1136	(ABC) transporter
AXE80_RS04135	COG0577	efflux transmembrane transporter activity
AXE80_RS04140	COG1136	(ABC) transporter
AXE80_RS04145	COG0741	lytic transglycosylase activity
AXE80_RS04145	COG1388	LysM domain
AXE80_RS04155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXE80_RS04160	COG4166	transmembrane transport
AXE80_RS04165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXE80_RS04170	COG0534	Mate efflux family protein
AXE80_RS04180	COG0009	L-threonylcarbamoyladenylate synthase
AXE80_RS04195	COG1187	pseudouridine synthase activity
AXE80_RS04220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AXE80_RS04225	COG0484	heat shock protein binding
AXE80_RS04240	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AXE80_RS04245	COG1120	ATPase activity
AXE80_RS04250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXE80_RS04255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AXE80_RS04260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AXE80_RS04275	COG1295	ribonuclease BN
AXE80_RS04280	COG2723	6-phospho-beta-galactosidase activity
AXE80_RS04310	COG0189	ligase activity
AXE80_RS04310	COG4067	protein conserved in archaea
AXE80_RS04315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AXE80_RS04320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AXE80_RS04325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AXE80_RS04330	COG0131	Imidazoleglycerol-phosphate dehydratase
AXE80_RS04335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AXE80_RS04340	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AXE80_RS04345	COG0107	imidazoleglycerol-phosphate synthase activity
AXE80_RS04350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AXE80_RS04350	COG0140	phosphoribosyl-ATP diphosphatase activity
AXE80_RS04355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AXE80_RS04365	COG2204	response regulator
AXE80_RS04370	COG1078	dGTPase activity
AXE80_RS04375	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXE80_RS04380	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AXE80_RS04380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AXE80_RS04385	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXE80_RS04390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AXE80_RS04395	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AXE80_RS04400	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_RS04410	COG1368	sulfuric ester hydrolase activity
AXE80_RS04415	COG0494	nUDIX hydrolase
AXE80_RS04440	COG3119	arylsulfatase activity
AXE80_RS04445	COG2226	methyltransferase
AXE80_RS04460	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AXE80_RS04470	COG2608	mercury ion transmembrane transporter activity
AXE80_RS04475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXE80_RS04480	COG2608	mercury ion transmembrane transporter activity
AXE80_RS04505	COG4774	siderophore transport
AXE80_RS04555	COG2264	protein methyltransferase activity
AXE80_RS04565	COG0149	triose-phosphate isomerase activity
AXE80_RS04580	COG0673	inositol 2-dehydrogenase activity
AXE80_RS04585	COG3119	arylsulfatase activity
AXE80_RS04635	COG0783	Belongs to the Dps family
AXE80_RS04640	COG0668	transmembrane transport
AXE80_RS04670	COG1858	cytochrome C peroxidase
AXE80_RS04680	COG1294	oxidase, subunit
AXE80_RS04685	COG1271	oxidase subunit
AXE80_RS04720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AXE80_RS04730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AXE80_RS04740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AXE80_RS04750	COG1193	negative regulation of DNA recombination
AXE80_RS04755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AXE80_RS04795	COG4628	conserved protein (DUF2132)
AXE80_RS04810	COG0488	(ABC) transporter
AXE80_RS04815	COG0745	RESPONSE REGULATOR receiver
AXE80_RS04820	COG5002	protein histidine kinase activity
AXE80_RS04850	COG0745	RESPONSE REGULATOR receiver
AXE80_RS04850	COG2205	protein histidine kinase activity
AXE80_RS04850	COG3292	Two component regulator propeller
AXE80_RS04855	COG2814	Major facilitator Superfamily
AXE80_RS04860	COG1621	beta-fructofuranosidase activity
AXE80_RS04865	COG4771	TonB-dependent receptor
AXE80_RS04870	COG0702	epimerase
AXE80_RS04905	COG0460	homoserine dehydrogenase
AXE80_RS04905	COG0527	aspartate kinase activity
AXE80_RS04910	COG0083	homoserine kinase activity
AXE80_RS04915	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AXE80_RS04920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AXE80_RS04960	COG0105	UTP biosynthetic process
AXE80_RS04965	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AXE80_RS04980	COG0215	cysteine-tRNA ligase activity
AXE80_RS04985	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AXE80_RS04990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AXE80_RS04995	COG3340	Belongs to the peptidase S51 family
AXE80_RS05000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXE80_RS05000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXE80_RS05015	COG1674	ftsk spoiiie
AXE80_RS05020	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AXE80_RS05060	COG0019	diaminopimelate decarboxylase activity
AXE80_RS05065	COG2195	Cleaves the N-terminal amino acid of tripeptides
AXE80_RS05080	COG2706	6-phosphogluconolactonase activity
AXE80_RS05105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AXE80_RS05125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXE80_RS05130	COG0018	arginyl-trna synthetase
AXE80_RS05145	COG2217	Heavy metal translocating P-type atpase
AXE80_RS05175	COG2010	Cytochrome c
AXE80_RS05180	COG0348	domain, Protein
AXE80_RS05195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AXE80_RS05215	COG3119	arylsulfatase activity
AXE80_RS05220	COG3876	Protein conserved in bacteria
AXE80_RS05230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AXE80_RS05240	COG1595	DNA-templated transcription, initiation
AXE80_RS05265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AXE80_RS05270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AXE80_RS05290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AXE80_RS05300	COG0436	Aminotransferase
AXE80_RS05310	COG0525	valine-tRNA ligase activity
AXE80_RS05320	COG0667	Aldo Keto reductase
AXE80_RS05325	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AXE80_RS05335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXE80_RS05340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXE80_RS05345	COG1253	flavin adenine dinucleotide binding
AXE80_RS05355	COG2346	COG2346, Truncated hemoglobins
AXE80_RS05375	COG0116	Belongs to the methyltransferase superfamily
AXE80_RS05410	COG0653	protein targeting
AXE80_RS05430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AXE80_RS05435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AXE80_RS05445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AXE80_RS05450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXE80_RS05460	COG1609	Transcriptional regulator
AXE80_RS05460	COG2207	Transcriptional regulator
AXE80_RS05465	COG2814	Major facilitator Superfamily
AXE80_RS05475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AXE80_RS05485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXE80_RS05490	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AXE80_RS05500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AXE80_RS05520	COG1595	DNA-templated transcription, initiation
AXE80_RS05545	COG0564	pseudouridine synthase activity
AXE80_RS05555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AXE80_RS05555	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AXE80_RS05600	COG1215	transferase activity, transferring glycosyl groups
AXE80_RS05610	COG0745	RESPONSE REGULATOR receiver
AXE80_RS05625	COG4977	sequence-specific DNA binding
AXE80_RS05625	COG1917	Cupin 2, conserved barrel domain protein
AXE80_RS05630	COG0640	Transcriptional regulator
AXE80_RS05675	COG2378	regulation of single-species biofilm formation
AXE80_RS05710	COG0640	Transcriptional regulator
AXE80_RS05730	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AXE80_RS05750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AXE80_RS05860	COG0492	ferredoxin-NADP+ reductase activity
AXE80_RS05880	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_RS05885	COG0702	epimerase
AXE80_RS05915	COG3408	Glycogen debranching enzyme
AXE80_RS05920	COG3292	Two component regulator propeller
AXE80_RS05920	COG0745	RESPONSE REGULATOR receiver
AXE80_RS05920	COG2205	protein histidine kinase activity
AXE80_RS05925	COG3250	beta-galactosidase activity
AXE80_RS05935	COG4771	TonB-dependent receptor
AXE80_RS05940	COG0702	epimerase
AXE80_RS05950	COG3119	arylsulfatase activity
AXE80_RS05950	COG3408	Glycogen debranching enzyme
AXE80_RS05955	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE80_RS05960	COG2188	Transcriptional regulator
AXE80_RS05965	COG0745	RESPONSE REGULATOR receiver
AXE80_RS05965	COG2205	protein histidine kinase activity
AXE80_RS05965	COG3292	Two component regulator propeller
AXE80_RS05970	COG3119	arylsulfatase activity
AXE80_RS05970	COG3408	Glycogen debranching enzyme
AXE80_RS05975	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE80_RS05980	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AXE80_RS05985	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
AXE80_RS05990	COG3119	arylsulfatase activity
AXE80_RS05995	COG3940	Belongs to the glycosyl hydrolase 43 family
AXE80_RS06000	COG1629	transport
AXE80_RS06010	COG1629	transport
AXE80_RS06015	COG0702	epimerase
AXE80_RS06030	COG3250	beta-galactosidase activity
AXE80_RS06050	COG3408	Glycogen debranching enzyme
AXE80_RS06055	COG3507	Belongs to the glycosyl hydrolase 43 family
AXE80_RS06070	COG3119	arylsulfatase activity
AXE80_RS06080	COG3119	arylsulfatase activity
AXE80_RS06095	COG3254	rhamnose metabolic process
AXE80_RS06110	COG3408	Glycogen debranching enzyme
AXE80_RS06115	COG3408	Glycogen debranching enzyme
AXE80_RS06120	COG3250	beta-galactosidase activity
AXE80_RS06125	COG3250	beta-galactosidase activity
AXE80_RS06130	COG3408	Glycogen debranching enzyme
AXE80_RS06130	COG3119	arylsulfatase activity
AXE80_RS06135	COG3940	Belongs to the glycosyl hydrolase 43 family
AXE80_RS06140	COG3119	arylsulfatase activity
AXE80_RS06145	COG3119	arylsulfatase activity
AXE80_RS06150	COG3119	arylsulfatase activity
AXE80_RS06155	COG3119	arylsulfatase activity
AXE80_RS06170	COG3347	Dehydrogenase
AXE80_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_RS06175	COG4952	isomerase
AXE80_RS06180	COG1070	Carbohydrate kinase
AXE80_RS06185	COG1304	FMN binding
AXE80_RS06200	COG1858	cytochrome C peroxidase
AXE80_RS06225	COG3708	Transcriptional regulator
AXE80_RS06225	COG2207	Transcriptional regulator
AXE80_RS06230	COG0492	ferredoxin-NADP+ reductase activity
AXE80_RS06235	COG0463	Glycosyl transferase, family 2
AXE80_RS06240	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AXE80_RS06245	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AXE80_RS06255	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AXE80_RS06260	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AXE80_RS06285	COG3119	arylsulfatase activity
AXE80_RS06290	COG0247	lactate metabolic process
AXE80_RS06305	COG1346	cytolysis
AXE80_RS06310	COG0494	nUDIX hydrolase
AXE80_RS06320	COG1104	cysteine desulfurase activity
AXE80_RS06325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AXE80_RS06340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXE80_RS06350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AXE80_RS06365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AXE80_RS06370	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AXE80_RS06380	COG0720	synthase
AXE80_RS06385	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AXE80_RS06410	COG1858	cytochrome C peroxidase
AXE80_RS06425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AXE80_RS06440	COG0628	permease
AXE80_RS06450	COG0561	phosphatase activity
AXE80_RS06460	COG0386	Belongs to the glutathione peroxidase family
AXE80_RS06465	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AXE80_RS06475	COG0784	Response regulator, receiver
AXE80_RS06475	COG2205	protein histidine kinase activity
AXE80_RS06480	COG2204	response regulator
AXE80_RS06505	COG0583	DNA-binding transcription factor activity
AXE80_RS06525	COG0514	ATP-dependent DNA helicase (RecQ)
AXE80_RS06535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AXE80_RS06545	COG1408	metallophosphoesterase
AXE80_RS06555	COG1217	gtp-binding protein TYPA
AXE80_RS06565	COG3012	SEC-C Motif Domain Protein
AXE80_RS06570	COG1960	acyl-CoA dehydrogenase activity
AXE80_RS06575	COG0183	Belongs to the thiolase family
AXE80_RS06580	COG1024	Enoyl-CoA hydratase
AXE80_RS06580	COG1250	3-hydroxyacyl-CoA dehydrogenase
AXE80_RS06590	COG4152	abc transporter atp-binding protein
AXE80_RS06635	COG1979	alcohol dehydrogenase
AXE80_RS06645	COG1309	transcriptional regulator
AXE80_RS06655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AXE80_RS06670	COG1879	ABC-type sugar transport system periplasmic component
AXE80_RS06680	COG1172	Belongs to the binding-protein-dependent transport system permease family
AXE80_RS06685	COG0246	Mannitol dehydrogenase
AXE80_RS06690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXE80_RS06695	COG1609	Transcriptional regulator
AXE80_RS06700	COG1629	transport
AXE80_RS06700	COG4206	TonB-dependent receptor
AXE80_RS06710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXE80_RS06730	COG2885	chlorophyll binding
AXE80_RS06750	COG1522	sequence-specific DNA binding
AXE80_RS06770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AXE80_RS06780	COG0516	GMP reductase activity
AXE80_RS06780	COG0517	IMP dehydrogenase activity
AXE80_RS06790	COG1301	dicarboxylic acid transport
AXE80_RS06835	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AXE80_RS06840	COG0667	Aldo Keto reductase
AXE80_RS06845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AXE80_RS06860	COG1401	restriction endodeoxyribonuclease activity
AXE80_RS06890	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AXE80_RS06920	COG0702	epimerase
AXE80_RS06925	COG4771	TonB-dependent receptor
AXE80_RS06930	COG3119	arylsulfatase activity
AXE80_RS06935	COG3119	arylsulfatase activity
AXE80_RS06970	COG1063	alcohol dehydrogenase
AXE80_RS06975	COG2721	sulfolactate sulfo-lyase activity
AXE80_RS06980	COG0246	Mannitol dehydrogenase
AXE80_RS06985	COG3618	amidohydrolase
AXE80_RS06990	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_RS06995	COG0738	Major facilitator superfamily
AXE80_RS07000	COG3254	rhamnose metabolic process
AXE80_RS07005	COG0745	RESPONSE REGULATOR receiver
AXE80_RS07005	COG3292	Two component regulator propeller
AXE80_RS07005	COG2205	protein histidine kinase activity
AXE80_RS07020	COG0673	inositol 2-dehydrogenase activity
AXE80_RS07060	COG0673	inositol 2-dehydrogenase activity
AXE80_RS07090	COG0513	Belongs to the DEAD box helicase family
AXE80_RS07150	COG1984	allophanate hydrolase subunit 2
AXE80_RS07155	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AXE80_RS07160	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AXE80_RS07190	COG2423	ornithine cyclodeaminase activity
AXE80_RS07195	COG2827	Endonuclease containing a URI domain
AXE80_RS07200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXE80_RS07205	COG4974	Belongs to the 'phage' integrase family
AXE80_RS07215	COG3177	Filamentation induced by cAMP protein fic
AXE80_RS07265	COG3177	Filamentation induced by cAMP protein fic
AXE80_RS07345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXE80_RS07350	COG3119	arylsulfatase activity
AXE80_RS07355	COG3119	arylsulfatase activity
AXE80_RS07400	COG3408	Glycogen debranching enzyme
AXE80_RS07400	COG3119	arylsulfatase activity
AXE80_RS07405	COG0702	epimerase
AXE80_RS07410	COG4771	TonB-dependent receptor
AXE80_RS07415	COG3119	arylsulfatase activity
AXE80_RS07430	COG3119	arylsulfatase activity
AXE80_RS07460	COG3119	arylsulfatase activity
AXE80_RS07470	COG0745	RESPONSE REGULATOR receiver
AXE80_RS07470	COG2205	protein histidine kinase activity
AXE80_RS07470	COG3292	Two component regulator propeller
AXE80_RS07500	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AXE80_RS07505	COG0497	DNA recombination
AXE80_RS07530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXE80_RS07535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXE80_RS07545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AXE80_RS07555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AXE80_RS07560	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AXE80_RS07565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AXE80_RS07570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AXE80_RS07575	COG0824	Thioesterase
AXE80_RS07580	COG1739	Uncharacterized protein family UPF0029
AXE80_RS07585	COG0697	spore germination
AXE80_RS07590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXE80_RS07590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXE80_RS07600	COG2890	protein-(glutamine-N5) methyltransferase activity
AXE80_RS07605	COG0336	Belongs to the RNA methyltransferase TrmD family
AXE80_RS07610	COG3119	arylsulfatase activity
AXE80_RS07615	COG0335	large ribosomal subunit rRNA binding
AXE80_RS07675	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_RS07685	COG2207	Transcriptional regulator
AXE80_RS07685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AXE80_RS07700	COG1733	regulation of RNA biosynthetic process
AXE80_RS07725	COG2267	carboxylic ester hydrolase activity
AXE80_RS07740	COG1132	(ABC) transporter
AXE80_RS07760	COG4771	TonB-dependent receptor
AXE80_RS07775	COG0556	nucleotide-excision repair
AXE80_RS07780	COG2307	Protein conserved in bacteria
AXE80_RS07780	COG2308	Evidence 4 Homologs of previously reported genes of
AXE80_RS07785	COG2308	Evidence 4 Homologs of previously reported genes of
AXE80_RS07795	COG2307	Protein conserved in bacteria
AXE80_RS07795	COG2308	Evidence 4 Homologs of previously reported genes of
AXE80_RS07810	COG2363	Small membrane protein
AXE80_RS07840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AXE80_RS07850	COG3201	nicotinamide mononucleotide transporter
AXE80_RS07875	COG0408	coproporphyrinogen oxidase activity
AXE80_RS07880	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AXE80_RS07890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AXE80_RS07895	COG0113	porphobilinogen synthase activity
AXE80_RS07905	COG0181	hydroxymethylbilane synthase activity
AXE80_RS07910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AXE80_RS07920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AXE80_RS07925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AXE80_RS07930	COG1981	membrane
AXE80_RS07945	COG1904	glucuronate isomerase
AXE80_RS07950	COG3119	arylsulfatase activity
AXE80_RS07955	COG5434	Belongs to the glycosyl hydrolase 28 family
AXE80_RS07960	COG3250	beta-galactosidase activity
AXE80_RS07965	COG3119	arylsulfatase activity
AXE80_RS07970	COG3119	arylsulfatase activity
AXE80_RS07975	COG3119	arylsulfatase activity
AXE80_RS07975	COG3408	Glycogen debranching enzyme
AXE80_RS07980	COG5434	Belongs to the glycosyl hydrolase 28 family
AXE80_RS07985	COG3119	arylsulfatase activity
AXE80_RS07995	COG3250	beta-galactosidase activity
AXE80_RS08000	COG3119	arylsulfatase activity
AXE80_RS08005	COG3119	arylsulfatase activity
AXE80_RS08020	COG3250	beta-galactosidase activity
AXE80_RS08030	COG3119	arylsulfatase activity
AXE80_RS08040	COG3119	arylsulfatase activity
AXE80_RS08045	COG3119	arylsulfatase activity
AXE80_RS08050	COG3119	arylsulfatase activity
AXE80_RS08075	COG5434	Belongs to the glycosyl hydrolase 28 family
AXE80_RS08085	COG0445	tRNA wobble uridine modification
AXE80_RS08090	COG3119	arylsulfatase activity
AXE80_RS08130	COG0702	epimerase
AXE80_RS08135	COG4771	TonB-dependent receptor
AXE80_RS08140	COG2205	protein histidine kinase activity
AXE80_RS08140	COG0745	RESPONSE REGULATOR receiver
AXE80_RS08140	COG3292	Two component regulator propeller
AXE80_RS08150	COG3250	beta-galactosidase activity
AXE80_RS08185	COG1196	nuclear chromosome segregation
AXE80_RS08190	COG3421	Type III restriction
AXE80_RS08200	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AXE80_RS08210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXE80_RS08220	COG2135	peptidase activity
AXE80_RS08250	COG4974	Belongs to the 'phage' integrase family
AXE80_RS08260	COG3118	belongs to the thioredoxin family
AXE80_RS08265	COG1410	methionine synthase
AXE80_RS08265	COG0646	methionine synthase
AXE80_RS08270	COG1410	methionine synthase
AXE80_RS08270	COG0646	methionine synthase
AXE80_RS08280	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE80_RS08300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AXE80_RS08320	COG0067	glutamate synthase
AXE80_RS08320	COG0069	glutamate synthase activity
AXE80_RS08320	COG0070	glutamate synthase
AXE80_RS08350	COG0514	ATP-dependent DNA helicase (RecQ)
AXE80_RS08360	COG0805	protein transport
AXE80_RS08365	COG1137	ATPase activity
AXE80_RS08385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AXE80_RS08410	COG0438	transferase activity, transferring glycosyl groups
AXE80_RS08440	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AXE80_RS08450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXE80_RS08455	COG1083	cytidylyl-transferase
AXE80_RS08460	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AXE80_RS08465	COG2089	acid synthase
AXE80_RS08475	COG0463	Glycosyl transferase, family 2
AXE80_RS08480	COG1216	Glycosyl transferase, family 2
AXE80_RS08480	COG1442	glycosyl transferase family 8
AXE80_RS08485	COG3274	enterobacterial common antigen metabolic process
AXE80_RS08490	COG0438	transferase activity, transferring glycosyl groups
AXE80_RS08495	COG1216	Glycosyl transferase, family 2
AXE80_RS08500	COG0463	Glycosyl transferase, family 2
AXE80_RS08505	COG0438	transferase activity, transferring glycosyl groups
AXE80_RS08525	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AXE80_RS08530	COG4974	Belongs to the 'phage' integrase family
AXE80_RS08535	COG1418	mRNA catabolic process
AXE80_RS08575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AXE80_RS08580	COG2827	Endonuclease containing a URI domain
AXE80_RS08600	COG1278	Cold shock
AXE80_RS08605	COG0738	Major facilitator superfamily
AXE80_RS08615	COG0716	FMN binding
AXE80_RS08650	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AXE80_RS08670	COG0450	alkyl hydroperoxide reductase
AXE80_RS08685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AXE80_RS08690	COG0569	domain protein
AXE80_RS08700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXE80_RS08720	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AXE80_RS08730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AXE80_RS08750	COG3011	Protein conserved in bacteria
AXE80_RS08780	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AXE80_RS08790	COG0259	pyridoxamine-phosphate oxidase activity
AXE80_RS08805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AXE80_RS08810	COG0483	inositol monophosphate 1-phosphatase activity
AXE80_RS08820	COG0527	aspartate kinase activity
AXE80_RS08835	COG0673	inositol 2-dehydrogenase activity
AXE80_RS08840	COG0644	oxidoreductase
AXE80_RS08845	COG1333	cytochrome c biogenesis protein
AXE80_RS08845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AXE80_RS08855	COG0438	transferase activity, transferring glycosyl groups
AXE80_RS08885	COG0702	epimerase
AXE80_RS08890	COG1629	transport
AXE80_RS08900	COG0657	acetylesterase activity
AXE80_RS08920	COG0745	RESPONSE REGULATOR receiver
AXE80_RS08920	COG2205	protein histidine kinase activity
AXE80_RS08920	COG3292	Two component regulator propeller
AXE80_RS08925	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AXE80_RS08930	COG1070	Carbohydrate kinase
AXE80_RS08940	COG0235	Class ii aldolase
AXE80_RS08945	COG1917	Cupin 2, conserved barrel domain protein
AXE80_RS08945	COG2207	Transcriptional regulator
AXE80_RS08955	COG1012	belongs to the aldehyde dehydrogenase family
AXE80_RS08960	COG0738	Major facilitator superfamily
AXE80_RS08965	COG1304	FMN binding
AXE80_RS08975	COG0174	glutamine synthetase
AXE80_RS08980	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AXE80_RS08985	COG1663	tetraacyldisaccharide 4'-kinase activity
AXE80_RS08990	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AXE80_RS09005	COG1278	Cold shock
AXE80_RS09010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AXE80_RS09015	COG0195	Participates in both transcription termination and antitermination
AXE80_RS09020	COG0779	Required for maturation of 30S ribosomal subunits
AXE80_RS09045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXE80_RS09045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXE80_RS09050	COG1368	sulfuric ester hydrolase activity
AXE80_RS09055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AXE80_RS09060	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AXE80_RS09065	COG0052	Belongs to the universal ribosomal protein uS2 family
AXE80_RS09070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AXE80_RS09075	COG0528	UMP kinase activity
AXE80_RS09080	COG0233	cytoplasmic translational termination
AXE80_RS09090	COG0659	secondary active sulfate transmembrane transporter activity
AXE80_RS09135	COG0415	Belongs to the DNA photolyase family
AXE80_RS09150	COG0432	Pfam Uncharacterised protein family UPF0047
AXE80_RS09155	COG0071	Belongs to the small heat shock protein (HSP20) family
AXE80_RS09165	COG0443	Heat shock 70 kDa protein
AXE80_RS09175	COG3022	response to hydroperoxide
AXE80_RS09180	COG0564	pseudouridine synthase activity
AXE80_RS09190	COG1181	Belongs to the D-alanine--D-alanine ligase family
AXE80_RS09195	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AXE80_RS09225	COG1132	(ABC) transporter
AXE80_RS09260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AXE80_RS09275	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AXE80_RS09305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AXE80_RS09310	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AXE80_RS09315	COG2115	Belongs to the xylose isomerase family
AXE80_RS09320	COG1070	Carbohydrate kinase
AXE80_RS09350	COG0564	pseudouridine synthase activity
AXE80_RS09375	COG0702	epimerase
AXE80_RS09380	COG4771	TonB-dependent receptor
AXE80_RS09390	COG1054	Belongs to the UPF0176 family
AXE80_RS09395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXE80_RS09395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AXE80_RS09415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AXE80_RS09425	COG0561	phosphatase activity
AXE80_RS09440	COG0542	response to heat
AXE80_RS09450	COG0450	alkyl hydroperoxide reductase
AXE80_RS09470	COG0488	(ABC) transporter
AXE80_RS09475	COG2223	nitrite transmembrane transporter activity
AXE80_RS09480	COG0778	Nitroreductase
AXE80_RS09490	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AXE80_RS09500	COG0424	maF-like protein
AXE80_RS09505	COG3958	Transketolase
AXE80_RS09510	COG0783	Belongs to the Dps family
AXE80_RS09515	COG0583	DNA-binding transcription factor activity
AXE80_RS09520	COG1022	Amp-dependent synthetase and ligase
AXE80_RS09530	COG0101	tRNA pseudouridine synthase activity
AXE80_RS09535	COG1132	(ABC) transporter
AXE80_RS09540	COG0251	oxidation-reduction process
AXE80_RS09545	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AXE80_RS09550	COG1803	Methylglyoxal synthase
AXE80_RS09560	COG0205	6-phosphofructokinase activity
AXE80_RS09575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AXE80_RS09595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AXE80_RS09610	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AXE80_RS09615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXE80_RS09620	COG2095	MarC family integral membrane protein
AXE80_RS09650	COG3123	guanosine phosphorylase activity
AXE80_RS09660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AXE80_RS09705	COG2197	response regulator
AXE80_RS09710	COG0488	(ABC) transporter
AXE80_RS09740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AXE80_RS09745	COG0217	transcriptional regulatory protein
AXE80_RS09785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AXE80_RS09810	COG0670	Belongs to the BI1 family
AXE80_RS09825	COG2197	response regulator
AXE80_RS09835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AXE80_RS09840	COG3290	protein histidine kinase activity
AXE80_RS09845	COG0657	acetylesterase activity
AXE80_RS09845	COG2755	lipolytic protein G-D-S-L family
AXE80_RS09850	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AXE80_RS09855	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AXE80_RS09870	COG1160	GTP binding
AXE80_RS09880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AXE80_RS09880	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AXE80_RS09915	COG1595	DNA-templated transcription, initiation
AXE80_RS09920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AXE80_RS09925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXE80_RS09930	COG1045	serine acetyltransferase
AXE80_RS09945	COG2095	MarC family integral membrane protein
AXE80_RS09970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AXE80_RS09990	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AXE80_RS09995	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AXE80_RS10010	COG0753	catalase activity
AXE80_RS10015	COG0579	oxidoreductase
AXE80_RS10020	COG5492	domain, Protein
AXE80_RS10030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXE80_RS10040	COG0343	queuine tRNA-ribosyltransferase activity
AXE80_RS10080	COG3119	arylsulfatase activity
AXE80_RS10115	COG0745	RESPONSE REGULATOR receiver
AXE80_RS10120	COG0612	Peptidase, M16
AXE80_RS10130	COG1012	belongs to the aldehyde dehydrogenase family
AXE80_RS10135	COG4948	Mandelate Racemase Muconate Lactonizing
AXE80_RS10145	COG0702	epimerase
AXE80_RS10150	COG1629	transport
AXE80_RS10155	COG3119	arylsulfatase activity
AXE80_RS10175	COG3734	2-keto-3-deoxy-galactonokinase
AXE80_RS10180	COG0800	Aldolase
AXE80_RS10185	COG2207	Transcriptional regulator
AXE80_RS10190	COG3119	arylsulfatase activity
AXE80_RS10210	COG2814	Major facilitator Superfamily
AXE80_RS10215	COG3119	arylsulfatase activity
AXE80_RS10220	COG0445	tRNA wobble uridine modification
AXE80_RS10225	COG3119	arylsulfatase activity
AXE80_RS10240	COG3119	arylsulfatase activity
AXE80_RS10250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AXE80_RS10255	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AXE80_RS10275	COG1999	signal sequence binding
AXE80_RS10280	COG0210	DNA helicase
AXE80_RS10285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXE80_RS10290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AXE80_RS10320	COG4124	Belongs to the glycosyl hydrolase 26 family
AXE80_RS10320	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AXE80_RS10330	COG3119	arylsulfatase activity
AXE80_RS10335	COG3693	PFAM glycoside hydrolase, family 10
AXE80_RS10345	COG3119	arylsulfatase activity
AXE80_RS10350	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE80_RS10355	COG0702	epimerase
AXE80_RS10360	COG4771	TonB-dependent receptor
AXE80_RS10365	COG0745	RESPONSE REGULATOR receiver
AXE80_RS10365	COG3292	Two component regulator propeller
AXE80_RS10365	COG2205	protein histidine kinase activity
AXE80_RS10365	COG0745	RESPONSE REGULATOR receiver
AXE80_RS10365	COG3292	Two component regulator propeller
AXE80_RS10365	COG2205	protein histidine kinase activity
AXE80_RS10375	COG1959	2 iron, 2 sulfur cluster binding
AXE80_RS10390	COG3119	arylsulfatase activity
AXE80_RS10410	COG3119	arylsulfatase activity
AXE80_RS10415	COG0745	RESPONSE REGULATOR receiver
AXE80_RS10415	COG2205	protein histidine kinase activity
AXE80_RS10415	COG3292	Two component regulator propeller
AXE80_RS10435	COG0561	phosphatase activity
AXE80_RS10440	COG1629	transport
AXE80_RS10450	COG0673	inositol 2-dehydrogenase activity
AXE80_RS10455	COG3408	Glycogen debranching enzyme
AXE80_RS10455	COG3119	arylsulfatase activity
AXE80_RS10475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXE80_RS10480	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AXE80_RS10500	COG1266	CAAX protease self-immunity
AXE80_RS10505	COG4948	Mandelate Racemase Muconate Lactonizing
AXE80_RS10520	COG1575	Belongs to the MenA family. Type 1 subfamily
AXE80_RS10525	COG0247	lactate metabolic process
AXE80_RS10525	COG2181	nitrate reductase activity
AXE80_RS10530	COG0247	lactate metabolic process
AXE80_RS10530	COG2181	nitrate reductase activity
AXE80_RS10540	COG0860	N-Acetylmuramoyl-L-alanine amidase
AXE80_RS10550	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AXE80_RS10580	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
AXE80_RS10590	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AXE80_RS10620	COG0012	GTP binding
AXE80_RS10630	COG1312	Catalyzes the dehydration of D-mannonate
AXE80_RS10635	COG3119	arylsulfatase activity
AXE80_RS10640	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_RS10645	COG2171	N-acyltransferase activity
AXE80_RS10650	COG2957	Belongs to the agmatine deiminase family
AXE80_RS10665	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AXE80_RS10670	COG0513	Belongs to the DEAD box helicase family
AXE80_RS10680	COG0513	Belongs to the DEAD box helicase family
AXE80_RS10700	COG0463	Glycosyl transferase, family 2
AXE80_RS10705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXE80_RS10710	COG1132	(ABC) transporter
AXE80_RS10725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXE80_RS10740	COG2197	response regulator
AXE80_RS10840	COG3392	D12 class N6 adenine-specific DNA methyltransferase
AXE80_RS10940	COG1764	response to oxidative stress
AXE80_RS10960	COG1012	belongs to the aldehyde dehydrogenase family
AXE80_RS10965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AXE80_RS10970	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AXE80_RS10985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AXE80_RS10985	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AXE80_RS10990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AXE80_RS10995	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AXE80_RS11000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AXE80_RS11020	COG0516	GMP reductase activity
AXE80_RS11025	COG1573	uracil-dna glycosylase
AXE80_RS11030	COG4977	sequence-specific DNA binding
AXE80_RS11050	COG1902	pentaerythritol trinitrate reductase activity
AXE80_RS11055	COG0825	malonyl-CoA metabolic process
AXE80_RS11065	COG1187	pseudouridine synthase activity
AXE80_RS11090	COG2081	HI0933 family
AXE80_RS11120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXE80_RS11130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXE80_RS11145	COG0514	ATP-dependent DNA helicase (RecQ)
AXE80_RS11150	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AXE80_RS11155	COG0776	regulation of translation
AXE80_RS11160	COG1678	Uncharacterized ACR, COG1678
AXE80_RS11180	COG1363	Peptidase, m42
AXE80_RS11185	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AXE80_RS11195	COG2271	Major facilitator Superfamily
AXE80_RS11200	COG2186	Transcriptional regulator
AXE80_RS11220	COG0702	epimerase
AXE80_RS11225	COG4771	TonB-dependent receptor
AXE80_RS11230	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_RS11250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AXE80_RS11250	COG0617	tRNA 3'-terminal CCA addition
AXE80_RS11250	COG0517	IMP dehydrogenase activity
AXE80_RS11255	COG0009	L-threonylcarbamoyladenylate synthase
AXE80_RS11270	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AXE80_RS11310	COG0438	transferase activity, transferring glycosyl groups
AXE80_RS11320	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AXE80_RS11340	COG1091	dTDP-4-dehydrorhamnose reductase activity
AXE80_RS11345	COG1088	dTDP-glucose 4,6-dehydratase activity
AXE80_RS11350	COG0242	peptide deformylase activity
AXE80_RS11360	COG3956	TIGRFAM MazG family protein
AXE80_RS11375	COG1607	acyl-coa hydrolase
AXE80_RS11380	COG0505	Belongs to the CarA family
AXE80_RS11385	COG0203	ribosomal protein L17
AXE80_RS11390	COG0202	RNA polymerase activity
AXE80_RS11395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AXE80_RS11400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AXE80_RS11405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AXE80_RS11410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AXE80_RS11415	COG0201	protein transport
AXE80_RS11420	COG0200	Binds to the 23S rRNA
AXE80_RS11425	COG1841	ribosomal large subunit assembly
AXE80_RS11430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AXE80_RS11440	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AXE80_RS11445	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AXE80_RS11450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AXE80_RS11455	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AXE80_RS11460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AXE80_RS11465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AXE80_RS11470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AXE80_RS11475	COG0255	Belongs to the universal ribosomal protein uL29 family
AXE80_RS11480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AXE80_RS11485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AXE80_RS11490	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AXE80_RS11495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AXE80_RS11500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AXE80_RS11505	COG0089	rRNA binding
AXE80_RS11510	COG0088	Forms part of the polypeptide exit tunnel
AXE80_RS11515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AXE80_RS11520	COG0051	transcription antitermination factor activity, RNA binding
AXE80_RS11525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AXE80_RS11530	COG0049	tRNA binding
AXE80_RS11535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AXE80_RS11550	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AXE80_RS11555	COG2226	methyltransferase
AXE80_RS11560	COG3119	arylsulfatase activity
AXE80_RS11565	COG3119	arylsulfatase activity
AXE80_RS11575	COG3693	PFAM glycoside hydrolase, family 10
AXE80_RS11585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXE80_RS11605	COG1215	transferase activity, transferring glycosyl groups
AXE80_RS11620	COG0148	phosphopyruvate hydratase activity
AXE80_RS11630	COG0848	biopolymer transport protein
AXE80_RS11640	COG0811	peptide transport
AXE80_RS11645	COG0252	asparaginase activity
AXE80_RS11650	COG0439	Biotin carboxylase
AXE80_RS11655	COG0511	ligase activity, forming carbon-carbon bonds
AXE80_RS11660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AXE80_RS11665	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AXE80_RS11675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AXE80_RS11680	COG0307	riboflavin synthase, alpha
AXE80_RS11690	COG0463	Glycosyl transferase, family 2
AXE80_RS11725	COG3279	Response regulator of the LytR AlgR family
AXE80_RS11735	COG5002	protein histidine kinase activity
AXE80_RS11745	COG4251	negative regulation of phosphorylation
AXE80_RS11755	COG0784	Response regulator, receiver
AXE80_RS11785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AXE80_RS11815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AXE80_RS11820	COG1968	undecaprenyl-diphosphatase activity
AXE80_RS11830	COG2177	Part of the ABC transporter FtsEX involved in
AXE80_RS11835	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AXE80_RS11845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AXE80_RS11860	COG3254	rhamnose metabolic process
AXE80_RS11865	COG0738	Major facilitator superfamily
AXE80_RS11870	COG3618	amidohydrolase
AXE80_RS11875	COG0800	Aldolase
AXE80_RS11885	COG1063	alcohol dehydrogenase
AXE80_RS11890	COG1609	Transcriptional regulator
AXE80_RS11900	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AXE80_RS11930	COG0791	NLP P60 protein
AXE80_RS11940	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AXE80_RS11950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXE80_RS11955	COG0542	response to heat
AXE80_RS11970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXE80_RS12010	COG0823	Involved in the tonB-independent uptake of proteins
AXE80_RS12010	COG1506	peptidase
AXE80_RS12020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AXE80_RS12025	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AXE80_RS12050	COG2967	ApaG domain
AXE80_RS12080	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AXE80_RS12105	COG2166	iron-sulfur cluster assembly
AXE80_RS12110	COG2151	metal-sulfur cluster biosynthetic enzyme
AXE80_RS12130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AXE80_RS12145	COG4124	Belongs to the glycosyl hydrolase 26 family
AXE80_RS12145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AXE80_RS12165	COG0066	3-isopropylmalate dehydratase activity
AXE80_RS12170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AXE80_RS12185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AXE80_RS12205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AXE80_RS12215	COG0194	GDP metabolic process
AXE80_RS12230	COG0791	NLP P60 protein
AXE80_RS12245	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AXE80_RS12260	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AXE80_RS12265	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AXE80_RS12270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AXE80_RS12280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AXE80_RS12295	COG0352	thiamine-phosphate diphosphorylase activity
AXE80_RS12295	COG0351	phosphomethylpyrimidine kinase
AXE80_RS12295	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AXE80_RS12305	COG0352	thiamine-phosphate diphosphorylase activity
AXE80_RS12315	COG2022	thiamine diphosphate biosynthetic process
AXE80_RS12320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AXE80_RS12335	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AXE80_RS12355	COG0471	metal ion transport
AXE80_RS12365	COG0187	DNA topoisomerase II activity
AXE80_RS12380	COG0039	L-malate dehydrogenase activity
AXE80_RS12395	COG0569	domain protein
AXE80_RS12400	COG2003	Belongs to the UPF0758 family
AXE80_RS12415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AXE80_RS12430	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AXE80_RS12440	COG0024	Methionine aminopeptidase
AXE80_RS12445	COG0671	phosphoesterase, PA-phosphatase related
AXE80_RS12450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AXE80_RS12455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXE80_RS12465	COG0101	tRNA pseudouridine synthase activity
AXE80_RS12470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AXE80_RS12475	COG1185	polyribonucleotide nucleotidyltransferase activity
AXE80_RS12495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AXE80_RS12500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AXE80_RS12505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AXE80_RS12540	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AXE80_RS12555	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXE80_RS12560	COG3604	Transcriptional regulator
AXE80_RS12580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AXE80_RS12585	COG0459	protein refolding
AXE80_RS12595	COG0297	glycogen (starch) synthase activity
AXE80_RS12600	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AXE80_RS12605	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AXE80_RS12615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AXE80_RS12620	COG2207	Transcriptional regulator
AXE80_RS12620	COG0662	Cupin 2, conserved barrel domain protein
AXE80_RS12645	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AXE80_RS12650	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AXE80_RS12665	COG1085	galactose-1-phosphate uridylyltransferase
AXE80_RS12670	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AXE80_RS12680	COG1725	Transcriptional regulator
AXE80_RS12690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AXE80_RS12695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AXE80_RS12700	COG0193	aminoacyl-tRNA hydrolase activity
AXE80_RS12705	COG3119	arylsulfatase activity
AXE80_RS12710	COG0720	synthase
AXE80_RS12755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXE80_RS12760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXE80_RS12765	COG1121	(ABC) transporter
AXE80_RS12770	COG0803	Belongs to the bacterial solute-binding protein 9 family
AXE80_RS12780	COG4771	TonB-dependent receptor
AXE80_RS12790	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AXE80_RS12810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AXE80_RS12835	COG3530	Putative quorum-sensing-regulated virulence factor
AXE80_RS12840	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AXE80_RS12850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXE80_RS12860	COG1538	Outer membrane efflux protein
AXE80_RS12870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXE80_RS12880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXE80_RS12890	COG0563	adenylate kinase activity
AXE80_RS12895	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AXE80_RS12900	COG0745	RESPONSE REGULATOR receiver
AXE80_RS12905	COG5002	protein histidine kinase activity
AXE80_RS12920	COG4585	Histidine kinase
AXE80_RS12940	COG2197	response regulator
AXE80_RS12945	COG0606	chelatase, subunit chli
AXE80_RS12960	COG0544	peptidyl-prolyl cis-trans isomerase activity
AXE80_RS12965	COG0596	Alpha beta hydrolase
AXE80_RS12970	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AXE80_RS12980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AXE80_RS12990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXE80_RS13010	COG3119	arylsulfatase activity
AXE80_RS13015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AXE80_RS13035	COG2226	methyltransferase
AXE80_RS13040	COG1477	protein flavinylation
AXE80_RS13050	COG2226	methyltransferase
AXE80_RS13060	COG3842	ATPase activity
AXE80_RS13075	COG1360	Flagellar Motor Protein
AXE80_RS13080	COG0708	Exodeoxyribonuclease III
AXE80_RS13085	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AXE80_RS13095	COG1774	PSP1 C-terminal conserved region
AXE80_RS13120	COG0509	glycine decarboxylation via glycine cleavage system
AXE80_RS13130	COG0632	four-way junction helicase activity
AXE80_RS13145	COG1519	Transferase
AXE80_RS13160	COG0166	Belongs to the GPI family
AXE80_RS13180	COG0571	ribonuclease III activity
AXE80_RS13185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXE80_RS13190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AXE80_RS13195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AXE80_RS13200	COG3341	Caulimovirus viroplasmin
AXE80_RS13200	COG0328	RNA-DNA hybrid ribonuclease activity
AXE80_RS13220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AXE80_RS13225	COG0322	excinuclease ABC activity
AXE80_RS13230	COG1752	Esterase of the alpha-beta hydrolase superfamily
AXE80_RS13245	COG0776	regulation of translation
AXE80_RS13255	COG0629	single-stranded DNA binding
AXE80_RS13285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AXE80_RS13290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AXE80_RS13295	COG0719	Fe-S assembly protein
AXE80_RS13300	COG0396	ATPase activity
AXE80_RS13310	COG0719	Fe-S assembly protein
AXE80_RS13315	COG0316	Belongs to the HesB IscA family
AXE80_RS13320	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AXE80_RS13335	COG4771	TonB-dependent receptor
AXE80_RS13340	COG0745	RESPONSE REGULATOR receiver
AXE80_RS13345	COG5002	protein histidine kinase activity
AXE80_RS13350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AXE80_RS13360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AXE80_RS13370	COG0594	ribonuclease P activity
AXE80_RS13380	COG1381	Involved in DNA repair and RecF pathway recombination
AXE80_RS13390	COG2954	triphosphatase activity
AXE80_RS13395	COG1272	protein, Hemolysin III
AXE80_RS13410	COG3250	beta-galactosidase activity
AXE80_RS13430	COG2124	cytochrome p450
AXE80_RS13435	COG1917	Cupin 2, conserved barrel domain protein
AXE80_RS13435	COG2207	Transcriptional regulator
AXE80_RS13440	COG0667	Aldo Keto reductase
AXE80_RS13445	COG0126	phosphoglycerate kinase activity
AXE80_RS13450	COG0470	DNA polymerase III
AXE80_RS13455	COG5002	protein histidine kinase activity
AXE80_RS13470	COG1595	DNA-templated transcription, initiation
AXE80_RS13490	COG2972	Histidine kinase
AXE80_RS13490	COG0745	RESPONSE REGULATOR receiver
AXE80_RS13495	COG3279	Response regulator of the LytR AlgR family
AXE80_RS13500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AXE80_RS13505	COG0445	tRNA wobble uridine modification
AXE80_RS13510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AXE80_RS13515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXE80_RS13535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AXE80_RS13545	COG0557	exoribonuclease II activity
AXE80_RS13555	COG0698	ribose 5-phosphate isomerase
AXE80_RS13565	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AXE80_RS13575	COG0793	Belongs to the peptidase S41A family
AXE80_RS13580	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXE80_RS13585	COG1472	Belongs to the glycosyl hydrolase 3 family
AXE80_RS13590	COG0714	Associated with various cellular activities
AXE80_RS13610	COG2304	oxidoreductase activity
AXE80_RS13635	COG0668	transmembrane transport
AXE80_RS13675	COG0792	nuclease activity
AXE80_RS13680	COG1619	proteins homologs of microcin C7 resistance protein MccF
AXE80_RS13685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXE80_RS13685	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXE80_RS13700	COG4109	DRTGG domain
AXE80_RS13710	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AXE80_RS13725	COG0006	proline dipeptidase activity
AXE80_RS13740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AXE80_RS13750	COG1119	ATPase activity
AXE80_RS13755	COG2721	sulfolactate sulfo-lyase activity
AXE80_RS13760	COG1028	Short-chain dehydrogenase reductase Sdr
AXE80_RS13765	COG0179	Fumarylacetoacetate (FAA) hydrolase
AXE80_RS13770	COG1304	FMN binding
AXE80_RS13775	COG0629	single-stranded DNA binding
AXE80_RS13815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AXE80_RS13820	COG4977	sequence-specific DNA binding
AXE80_RS13830	COG1053	succinate dehydrogenase
AXE80_RS13835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AXE80_RS13840	COG2045	Belongs to the ComB family
AXE80_RS13845	COG0084	hydrolase, TatD family'
AXE80_RS13850	COG0038	chloride channel
AXE80_RS13870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AXE80_RS13875	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AXE80_RS13885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AXE80_RS13895	COG3852	Histidine kinase
AXE80_RS13910	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AXE80_RS13950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AXE80_RS13965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXE80_RS13975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AXE80_RS13980	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AXE80_RS14000	COG3769	mannosylglycerate metabolic process
AXE80_RS14005	COG2379	hydroxypyruvate reductase
AXE80_RS14010	COG1215	transferase activity, transferring glycosyl groups
AXE80_RS14015	COG0366	Alpha amylase catalytic
AXE80_RS14020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXE80_RS14055	COG0356	it plays a direct role in the translocation of protons across the membrane
AXE80_RS14060	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXE80_RS14065	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AXE80_RS14070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXE80_RS14075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AXE80_RS14080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AXE80_RS14100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AXE80_RS14145	COG0489	protein tyrosine kinase activity
AXE80_RS14155	COG0488	(ABC) transporter
AXE80_RS14195	COG0758	DNA mediated transformation
AXE80_RS14195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXE80_RS14205	COG0756	dUTP diphosphatase activity