locus-tag	class	description
WM2015_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WM2015_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WM2015_RS00020	COG0187	DNA topoisomerase II activity
WM2015_RS00030	COG0751	glycine-tRNA ligase activity
WM2015_RS00040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WM2015_RS00040	COG0519	Catalyzes the synthesis of GMP from XMP
WM2015_RS00050	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
WM2015_RS00055	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WM2015_RS00075	COG0500	methyltransferase
WM2015_RS00085	COG0733	neurotransmitter:sodium symporter activity
WM2015_RS00095	COG1136	(ABC) transporter
WM2015_RS00110	COG1506	peptidase
WM2015_RS00110	COG0823	Involved in the tonB-independent uptake of proteins
WM2015_RS00115	COG2954	triphosphatase activity
WM2015_RS00125	COG0626	cystathionine gamma-synthase activity
WM2015_RS00130	COG3706	GGDEF domain
WM2015_RS00150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WM2015_RS00155	COG0004	ammonium transporteR
WM2015_RS00180	COG0433	COG0433 Predicted ATPase
WM2015_RS00195	COG1278	Cold shock
WM2015_RS00205	COG0076	glutamate decarboxylase activity
WM2015_RS00260	COG0842	Transport permease protein
WM2015_RS00265	COG1131	(ABC) transporter
WM2015_RS00315	COG2304	oxidoreductase activity
WM2015_RS00355	COG1228	amidohydrolase
WM2015_RS00370	COG1404	Belongs to the peptidase S8 family
WM2015_RS00405	COG3275	phosphorelay sensor kinase activity
WM2015_RS00415	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WM2015_RS00420	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
WM2015_RS00445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WM2015_RS00460	COG4946	Tricorn protease homolog
WM2015_RS00460	COG0793	Belongs to the peptidase S41A family
WM2015_RS00470	COG1136	(ABC) transporter
WM2015_RS00470	COG0577	efflux transmembrane transporter activity
WM2015_RS00475	COG1136	(ABC) transporter
WM2015_RS00480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM2015_RS00510	COG0436	Aminotransferase
WM2015_RS00515	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
WM2015_RS00520	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
WM2015_RS00525	COG0235	Class ii aldolase
WM2015_RS00555	COG1228	amidohydrolase
WM2015_RS00565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WM2015_RS00570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WM2015_RS00575	COG2003	Belongs to the UPF0758 family
WM2015_RS00580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WM2015_RS00585	COG0756	dUTP diphosphatase activity
WM2015_RS00590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WM2015_RS00615	COG0601	transmembrane transport
WM2015_RS00620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WM2015_RS00635	COG4608	Belongs to the ABC transporter superfamily
WM2015_RS00650	COG1192	Involved in chromosome partitioning
WM2015_RS00655	COG1475	DNA binding
WM2015_RS00660	COG5000	phosphorelay sensor kinase activity
WM2015_RS00670	COG0577	efflux transmembrane transporter activity
WM2015_RS00670	COG1136	(ABC) transporter
WM2015_RS00675	COG0577	efflux transmembrane transporter activity
WM2015_RS00680	COG1136	(ABC) transporter
WM2015_RS00680	COG0577	efflux transmembrane transporter activity
WM2015_RS00690	COG0300	oxidoreductase activity
WM2015_RS00700	COG0356	it plays a direct role in the translocation of protons across the membrane
WM2015_RS00710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WM2015_RS00715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WM2015_RS00720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WM2015_RS00725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WM2015_RS00730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WM2015_RS00735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WM2015_RS00740	COG1404	Belongs to the peptidase S8 family
WM2015_RS00760	COG0037	tRNA processing
WM2015_RS00770	COG2937	Belongs to the GPAT DAPAT family
WM2015_RS00775	COG0284	orotidine-5'-phosphate decarboxylase activity
WM2015_RS00780	COG0596	Alpha beta hydrolase
WM2015_RS00785	COG0210	DNA helicase
WM2015_RS00790	COG0151	Belongs to the GarS family
WM2015_RS00795	COG0138	bifunctional purine biosynthesis protein purh
WM2015_RS00815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WM2015_RS00820	COG1136	(ABC) transporter
WM2015_RS00835	COG0457	Tetratricopeptide repeat
WM2015_RS00840	COG0708	Exodeoxyribonuclease III
WM2015_RS00845	COG2211	Major facilitator Superfamily
WM2015_RS00880	COG4942	peptidase
WM2015_RS00885	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WM2015_RS00900	COG1592	Rubrerythrin
WM2015_RS00910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WM2015_RS00915	COG0137	argininosuccinate synthase activity
WM2015_RS00920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WM2015_RS00925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WM2015_RS00935	COG0165	Argininosuccinate lyase
WM2015_RS00970	COG1301	dicarboxylic acid transport
WM2015_RS00975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WM2015_RS00995	COG1970	mechanosensitive ion channel activity
WM2015_RS01020	COG0745	RESPONSE REGULATOR receiver
WM2015_RS01030	COG4946	Tricorn protease homolog
WM2015_RS01030	COG0823	Involved in the tonB-independent uptake of proteins
WM2015_RS01030	COG1506	peptidase
WM2015_RS01035	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WM2015_RS01040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM2015_RS01045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM2015_RS01050	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
WM2015_RS01055	COG3458	cephalosporin-C deacetylase activity
WM2015_RS01075	COG0625	glutathione transferase activity
WM2015_RS01090	COG0515	serine threonine protein kinase
WM2015_RS01125	COG1024	Enoyl-CoA hydratase
WM2015_RS01140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WM2015_RS01145	COG1077	Cell shape determining protein MreB Mrl
WM2015_RS01150	COG1792	Involved in formation and maintenance of cell shape
WM2015_RS01160	COG0768	penicillin binding
WM2015_RS01165	COG0772	Belongs to the SEDS family
WM2015_RS01170	COG2951	lytic endotransglycosylase activity
WM2015_RS01180	COG1686	Belongs to the peptidase S11 family
WM2015_RS01185	COG2921	Belongs to the UPF0250 family
WM2015_RS01190	COG0321	lipoyl(octanoyl) transferase activity
WM2015_RS01200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WM2015_RS01210	COG0405	Gamma-glutamyltransferase
WM2015_RS01215	COG0254	rRNA binding
WM2015_RS01260	COG3275	phosphorelay sensor kinase activity
WM2015_RS01270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WM2015_RS01280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WM2015_RS01285	COG1561	YicC-like family, N-terminal region
WM2015_RS01290	COG0194	GDP metabolic process
WM2015_RS01295	COG1758	RNA polymerase activity
WM2015_RS01300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WM2015_RS01315	COG0473	3-isopropylmalate dehydrogenase activity
WM2015_RS01335	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_RS01340	COG0586	Pfam SNARE associated Golgi protein
WM2015_RS01345	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WM2015_RS01350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WM2015_RS01360	COG0425	Belongs to the sulfur carrier protein TusA family
WM2015_RS01370	COG0205	6-phosphofructokinase activity
WM2015_RS01375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WM2015_RS01380	COG0446	pyridine nucleotide-disulphide oxidoreductase
WM2015_RS01395	COG1595	DNA-templated transcription, initiation
WM2015_RS01410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WM2015_RS01415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WM2015_RS01420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WM2015_RS01425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WM2015_RS01430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WM2015_RS01440	COG0358	DNA primase activity
WM2015_RS01445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WM2015_RS01460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WM2015_RS01465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WM2015_RS01470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WM2015_RS01490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WM2015_RS01505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WM2015_RS01515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WM2015_RS01520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WM2015_RS01560	COG0408	coproporphyrinogen oxidase activity
WM2015_RS01565	COG1754	DNA topoisomerase type I activity
WM2015_RS01565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WM2015_RS01570	COG2922	Belongs to the Smg family
WM2015_RS01575	COG0758	DNA mediated transformation
WM2015_RS01585	COG0242	peptide deformylase activity
WM2015_RS01605	COG5000	phosphorelay sensor kinase activity
WM2015_RS01610	COG2204	response regulator
WM2015_RS01615	COG0569	domain protein
WM2015_RS01620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WM2015_RS01625	COG0009	L-threonylcarbamoyladenylate synthase
WM2015_RS01630	COG1560	Kdo2-lipid A biosynthetic process
WM2015_RS01640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WM2015_RS01640	COG0116	Belongs to the methyltransferase superfamily
WM2015_RS01655	COG1136	(ABC) transporter
WM2015_RS01660	COG4591	ABC-type transport system involved in lipoprotein release permease component
WM2015_RS01675	COG0471	metal ion transport
WM2015_RS01675	COG3273	potassium ion transport
WM2015_RS01680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WM2015_RS01685	COG0471	metal ion transport
WM2015_RS01685	COG3273	potassium ion transport
WM2015_RS01690	COG1331	Highly conserved protein containing a thioredoxin domain
WM2015_RS01710	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WM2015_RS01720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WM2015_RS01740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM2015_RS01740	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WM2015_RS01755	COG0509	glycine decarboxylation via glycine cleavage system
WM2015_RS01760	COG1515	deoxyribonuclease V activity
WM2015_RS01775	COG0459	protein refolding
WM2015_RS01780	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WM2015_RS01790	COG4232	protein-disulfide reductase activity
WM2015_RS01795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WM2015_RS01800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WM2015_RS01805	COG0511	ligase activity, forming carbon-carbon bonds
WM2015_RS01810	COG0439	Biotin carboxylase
WM2015_RS01820	COG2198	Histidine kinase
WM2015_RS01820	COG0784	Response regulator, receiver
WM2015_RS01820	COG0643	Histidine kinase
WM2015_RS01825	COG0840	transmembrane signaling receptor activity
WM2015_RS01840	COG0189	ligase activity
WM2015_RS01845	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
WM2015_RS01855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WM2015_RS01860	COG0540	Belongs to the ATCase OTCase family
WM2015_RS01870	COG0471	metal ion transport
WM2015_RS01870	COG3273	potassium ion transport
WM2015_RS01890	COG0651	ATP synthesis coupled electron transport
WM2015_RS01900	COG0651	ATP synthesis coupled electron transport
WM2015_RS01905	COG0651	ATP synthesis coupled electron transport
WM2015_RS01910	COG1006	Multisubunit Na H antiporter MnhC subunit
WM2015_RS01925	COG1320	monovalent cation:proton antiporter activity
WM2015_RS01940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WM2015_RS01945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WM2015_RS01950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WM2015_RS01955	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
WM2015_RS01965	COG1446	asparaginase
WM2015_RS01975	COG0494	nUDIX hydrolase
WM2015_RS01985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WM2015_RS01985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WM2015_RS01995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WM2015_RS02000	COG0531	amino acid
WM2015_RS02015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WM2015_RS02025	COG0142	geranyltranstransferase activity
WM2015_RS02035	COG0564	pseudouridine synthase activity
WM2015_RS02045	COG0069	glutamate synthase activity
WM2015_RS02055	COG0504	CTP synthase activity
WM2015_RS02060	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WM2015_RS02065	COG0148	phosphopyruvate hydratase activity
WM2015_RS02090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WM2015_RS02095	COG0252	asparaginase activity
WM2015_RS02115	COG1393	Belongs to the ArsC family
WM2015_RS02120	COG1295	ribonuclease BN
WM2015_RS02120	COG1959	2 iron, 2 sulfur cluster binding
WM2015_RS02125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WM2015_RS02130	COG1254	Belongs to the acylphosphatase family
WM2015_RS02145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WM2015_RS02155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WM2015_RS02160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WM2015_RS02165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WM2015_RS02175	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM2015_RS02185	COG0575	Belongs to the CDS family
WM2015_RS02190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WM2015_RS02195	COG0233	cytoplasmic translational termination
WM2015_RS02200	COG0528	UMP kinase activity
WM2015_RS02205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WM2015_RS02210	COG0052	Belongs to the universal ribosomal protein uS2 family
WM2015_RS02215	COG1054	Belongs to the UPF0176 family
WM2015_RS02220	COG3264	Mechanosensitive ion channel
WM2015_RS02220	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WM2015_RS02225	COG0442	prolyl-tRNA aminoacylation
WM2015_RS02235	COG1183	phosphatidylcholine synthase activity
WM2015_RS02340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WM2015_RS02365	COG0811	peptide transport
WM2015_RS02370	COG0811	peptide transport
WM2015_RS02375	COG0848	biopolymer transport protein
WM2015_RS02400	COG4974	Belongs to the 'phage' integrase family
WM2015_RS02405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WM2015_RS02420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WM2015_RS02425	COG1459	type II secretion system
WM2015_RS02430	COG2165	general secretion pathway protein
WM2015_RS02435	COG4970	Tfp pilus assembly protein FimT
WM2015_RS02440	COG2165	general secretion pathway protein
WM2015_RS02450	COG3156	type II secretion system protein K
WM2015_RS02470	COG1450	Type ii and iii secretion system protein
WM2015_RS02490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WM2015_RS02530	COG0488	(ABC) transporter
WM2015_RS02535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WM2015_RS02540	COG0515	serine threonine protein kinase
WM2015_RS02550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WM2015_RS02565	COG0217	transcriptional regulatory protein
WM2015_RS02570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WM2015_RS02575	COG0632	four-way junction helicase activity
WM2015_RS02585	COG0824	Thioesterase
WM2015_RS02610	COG2885	chlorophyll binding
WM2015_RS02620	COG0602	queuosine metabolic process
WM2015_RS02625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WM2015_RS02635	COG0175	sulfate reduction
WM2015_RS02650	COG0612	Peptidase, M16
WM2015_RS02655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WM2015_RS02660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WM2015_RS02670	COG1067	ATP-dependent peptidase activity
WM2015_RS02680	COG0527	aspartate kinase activity
WM2015_RS02695	COG2815	serine threonine protein kinase
WM2015_RS02695	COG0515	serine threonine protein kinase
WM2015_RS02700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WM2015_RS02705	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
WM2015_RS02720	COG0488	(ABC) transporter
WM2015_RS02730	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
WM2015_RS02735	COG1278	Cold shock
WM2015_RS02750	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
WM2015_RS02755	COG0671	phosphoesterase, PA-phosphatase related
WM2015_RS02760	COG0720	synthase
WM2015_RS02770	COG2226	methyltransferase
WM2015_RS02780	COG2264	protein methyltransferase activity
WM2015_RS02785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WM2015_RS02835	COG0483	inositol monophosphate 1-phosphatase activity
WM2015_RS02840	COG0494	nUDIX hydrolase
WM2015_RS02850	COG1981	membrane
WM2015_RS02855	COG0316	Belongs to the HesB IscA family
WM2015_RS02860	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
WM2015_RS02875	COG0577	efflux transmembrane transporter activity
WM2015_RS02880	COG1136	(ABC) transporter
WM2015_RS02890	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
WM2015_RS02895	COG0166	Belongs to the GPI family
WM2015_RS02905	COG3220	belongs to the UPF0276 family
WM2015_RS02915	COG2259	Doxx family
WM2015_RS02920	COG0495	leucyl-tRNA aminoacylation
WM2015_RS02935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WM2015_RS02950	COG0424	maF-like protein
WM2015_RS02965	COG0312	modulator of DNA gyrase
WM2015_RS02970	COG0312	modulator of DNA gyrase
WM2015_RS02985	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_RS02995	COG0149	triose-phosphate isomerase activity
WM2015_RS03010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM2015_RS03015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM2015_RS03020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM2015_RS03025	COG0649	NAD binding
WM2015_RS03035	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WM2015_RS03040	COG1034	ATP synthesis coupled electron transport
WM2015_RS03045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WM2015_RS03050	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM2015_RS03060	COG0713	ATP synthesis coupled electron transport
WM2015_RS03080	COG1007	ATP synthesis coupled electron transport
WM2015_RS03085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WM2015_RS03090	COG1214	PFAM Peptidase M22, glycoprotease
WM2015_RS03120	COG1199	ATP-dependent helicase activity
WM2015_RS03130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WM2015_RS03135	COG0438	transferase activity, transferring glycosyl groups
WM2015_RS03135	COG1216	Glycosyl transferase, family 2
WM2015_RS03150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WM2015_RS03180	COG1643	Atp-dependent helicase
WM2015_RS03190	COG1137	ATPase activity
WM2015_RS03205	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WM2015_RS03225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WM2015_RS03230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WM2015_RS03235	COG1538	Outer membrane efflux protein
WM2015_RS03240	COG1519	Transferase
WM2015_RS03245	COG1560	Kdo2-lipid A biosynthetic process
WM2015_RS03250	COG0463	Glycosyl transferase, family 2
WM2015_RS03260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WM2015_RS03265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WM2015_RS03285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WM2015_RS03295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WM2015_RS03295	COG0543	2 iron, 2 sulfur cluster binding
WM2015_RS03320	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
WM2015_RS03325	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
WM2015_RS03330	COG3639	organic phosphonate transmembrane transporter activity
WM2015_RS03335	COG3639	organic phosphonate transmembrane transporter activity
WM2015_RS03340	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
WM2015_RS03355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WM2015_RS03390	COG4585	Histidine kinase
WM2015_RS03395	COG2197	response regulator
WM2015_RS03400	COG2234	aminopeptidase activity
WM2015_RS03435	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WM2015_RS03440	COG2171	N-acyltransferase activity
WM2015_RS03445	COG1393	Belongs to the ArsC family
WM2015_RS03450	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WM2015_RS03480	COG0457	Tetratricopeptide repeat
WM2015_RS03505	COG2081	HI0933 family
WM2015_RS03520	COG2815	serine threonine protein kinase
WM2015_RS03520	COG0515	serine threonine protein kinase
WM2015_RS03565	COG0339	signal peptide processing
WM2015_RS03620	COG1301	dicarboxylic acid transport
WM2015_RS03640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WM2015_RS03655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WM2015_RS03665	COG2326	polyphosphate kinase activity
WM2015_RS03720	COG1404	Belongs to the peptidase S8 family
WM2015_RS03745	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WM2015_RS03750	COG0438	transferase activity, transferring glycosyl groups
WM2015_RS03770	COG2031	fatty acid transporter
WM2015_RS03775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WM2015_RS03780	COG1162	GTPase activity
WM2015_RS03800	COG2267	carboxylic ester hydrolase activity
WM2015_RS03810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WM2015_RS03815	COG1959	2 iron, 2 sulfur cluster binding
WM2015_RS03840	COG3384	dioxygenase
WM2015_RS03845	COG2259	Doxx family
WM2015_RS03850	COG0583	DNA-binding transcription factor activity
WM2015_RS03865	COG1247	-acetyltransferase
WM2015_RS03925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WM2015_RS03935	COG0435	Glutathione S-transferase
WM2015_RS03950	COG2815	serine threonine protein kinase
WM2015_RS03950	COG0515	serine threonine protein kinase
WM2015_RS04000	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
WM2015_RS04020	COG1598	PFAM Uncharacterised protein family UPF0150
WM2015_RS04055	COG3655	Transcriptional regulator
WM2015_RS04075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WM2015_RS04115	COG2311	Membrane
WM2015_RS04135	COG0288	reversible hydration of carbon dioxide
WM2015_RS04140	COG3710	Transcriptional regulator
WM2015_RS04140	COG0457	Tetratricopeptide repeat
WM2015_RS04210	COG4771	TonB-dependent receptor
WM2015_RS04230	COG0515	serine threonine protein kinase
WM2015_RS04230	COG2815	serine threonine protein kinase
WM2015_RS04235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM2015_RS04240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM2015_RS04260	COG0123	including yeast histone deacetylase and acetoin utilization protein
WM2015_RS04265	COG2096	Adenosyltransferase
WM2015_RS04315	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WM2015_RS04340	COG0457	Tetratricopeptide repeat
WM2015_RS04340	COG0463	Glycosyl transferase, family 2
WM2015_RS04350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM2015_RS04355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM2015_RS04365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WM2015_RS04380	COG2311	Membrane
WM2015_RS04435	COG1113	amino acid transport
WM2015_RS04450	COG1063	alcohol dehydrogenase
WM2015_RS04520	COG1012	belongs to the aldehyde dehydrogenase family
WM2015_RS04525	COG0471	metal ion transport
WM2015_RS04530	COG0542	response to heat
WM2015_RS04565	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WM2015_RS04570	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WM2015_RS04575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WM2015_RS04585	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WM2015_RS04590	COG0617	tRNA 3'-terminal CCA addition
WM2015_RS04595	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WM2015_RS04600	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WM2015_RS04605	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WM2015_RS04610	COG1192	Involved in chromosome partitioning
WM2015_RS04640	COG3273	potassium ion transport
WM2015_RS04640	COG0471	metal ion transport
WM2015_RS04655	COG3028	Belongs to the UPF0307 family
WM2015_RS04690	COG2321	neutral zinc metallopeptidase
WM2015_RS04700	COG0347	Belongs to the P(II) protein family
WM2015_RS04710	COG1131	(ABC) transporter
WM2015_RS04720	COG1228	amidohydrolase
WM2015_RS04725	COG4585	Histidine kinase
WM2015_RS04730	COG2197	response regulator
WM2015_RS04745	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
WM2015_RS04750	COG5001	Diguanylate cyclase
WM2015_RS04750	COG2203	Gaf domain
WM2015_RS04750	COG4251	negative regulation of phosphorylation
WM2015_RS04750	COG3706	GGDEF domain
WM2015_RS04760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WM2015_RS04765	COG5380	lipid catabolic process
WM2015_RS04770	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WM2015_RS04780	COG2815	serine threonine protein kinase
WM2015_RS04780	COG0515	serine threonine protein kinase
WM2015_RS04815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WM2015_RS04820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WM2015_RS04830	COG0436	Aminotransferase
WM2015_RS04835	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WM2015_RS04845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WM2015_RS04845	COG1042	CoA-binding domain protein
WM2015_RS04845	COG0045	succinate-CoA ligase (ADP-forming) activity
WM2015_RS04850	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WM2015_RS04855	COG1968	undecaprenyl-diphosphatase activity
WM2015_RS04860	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WM2015_RS04870	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WM2015_RS04875	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_RS04905	COG2153	protein acetylation
WM2015_RS04945	COG3094	Invasion gene expression up-regulator, SirB
WM2015_RS04950	COG0427	acetyl-CoA hydrolase
WM2015_RS05035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM2015_RS05050	COG0745	RESPONSE REGULATOR receiver
WM2015_RS05055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WM2015_RS05075	COG1201	RNA secondary structure unwinding
WM2015_RS05080	COG1793	dna ligase
WM2015_RS05095	COG0823	Involved in the tonB-independent uptake of proteins
WM2015_RS05095	COG1506	peptidase
WM2015_RS05095	COG4946	Tricorn protease homolog
WM2015_RS05110	COG5505	Protein of unknown function (DUF819)
WM2015_RS05135	COG2239	Acts as a magnesium transporter
WM2015_RS05180	COG0493	'glutamate synthase
WM2015_RS05185	COG0070	glutamate synthase
WM2015_RS05185	COG0067	glutamate synthase
WM2015_RS05185	COG0069	glutamate synthase activity
WM2015_RS05190	COG4243	Vitamin k epoxide reductase
WM2015_RS05210	COG0492	ferredoxin-NADP+ reductase activity
WM2015_RS05215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WM2015_RS05225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WM2015_RS05230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WM2015_RS05235	COG0006	proline dipeptidase activity
WM2015_RS05250	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
WM2015_RS05255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WM2015_RS05265	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WM2015_RS05275	COG3706	GGDEF domain
WM2015_RS05280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WM2015_RS05285	COG1834	amidinotransferase
WM2015_RS05305	COG3956	TIGRFAM MazG family protein
WM2015_RS05320	COG4106	trans-aconitate 2-methyltransferase activity
WM2015_RS05355	COG2183	response to ionizing radiation
WM2015_RS05370	COG1404	Belongs to the peptidase S8 family
WM2015_RS05385	COG0545	Peptidyl-prolyl cis-trans isomerase
WM2015_RS05390	COG0515	serine threonine protein kinase
WM2015_RS05390	COG2815	serine threonine protein kinase
WM2015_RS05420	COG0515	serine threonine protein kinase
WM2015_RS05435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WM2015_RS05475	COG1024	Enoyl-CoA hydratase
WM2015_RS05480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WM2015_RS05490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WM2015_RS05495	COG1185	polyribonucleotide nucleotidyltransferase activity
WM2015_RS05510	COG0859	PFAM glycosyl transferase family 9
WM2015_RS05515	COG3642	lipopolysaccharide core region biosynthetic process
WM2015_RS05520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WM2015_RS05535	COG0697	spore germination
WM2015_RS05545	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
WM2015_RS05560	COG2166	iron-sulfur cluster assembly
WM2015_RS05565	COG0215	cysteine-tRNA ligase activity
WM2015_RS05600	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WM2015_RS05605	COG2828	Protein conserved in bacteria
WM2015_RS05630	COG0823	Involved in the tonB-independent uptake of proteins
WM2015_RS05665	COG0655	NAD(P)H dehydrogenase (quinone) activity
WM2015_RS05670	COG0583	DNA-binding transcription factor activity
WM2015_RS05680	COG0697	spore germination
WM2015_RS05790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WM2015_RS05800	COG3119	arylsulfatase activity
WM2015_RS05840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM2015_RS05865	COG2815	serine threonine protein kinase
WM2015_RS05865	COG0515	serine threonine protein kinase
WM2015_RS05905	COG0823	Involved in the tonB-independent uptake of proteins
WM2015_RS05905	COG1506	peptidase
WM2015_RS05940	COG1288	antiporter activity
WM2015_RS05970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WM2015_RS06010	COG0714	Associated with various cellular activities
WM2015_RS06045	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WM2015_RS06060	COG0604	alcohol dehydrogenase
WM2015_RS06060	COG3321	synthase
WM2015_RS06080	COG1017	nitric oxide dioxygenase activity
WM2015_RS06080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WM2015_RS06085	COG1309	transcriptional regulator
WM2015_RS06090	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WM2015_RS06135	COG3706	GGDEF domain
WM2015_RS06140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WM2015_RS06170	COG1960	acyl-CoA dehydrogenase activity
WM2015_RS06195	COG0640	Transcriptional regulator
WM2015_RS06200	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WM2015_RS06200	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WM2015_RS06200	COG1703	isobutyryl-CoA mutase activity
WM2015_RS06220	COG0587	DNA-directed DNA polymerase activity
WM2015_RS06230	COG0515	serine threonine protein kinase
WM2015_RS06260	COG2205	protein histidine kinase activity
WM2015_RS06265	COG0745	RESPONSE REGULATOR receiver
WM2015_RS06270	COG2304	oxidoreductase activity
WM2015_RS06280	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WM2015_RS06300	COG2815	serine threonine protein kinase
WM2015_RS06300	COG0515	serine threonine protein kinase
WM2015_RS06350	COG0544	peptidyl-prolyl cis-trans isomerase activity
WM2015_RS06355	COG0740	serine-type endopeptidase activity
WM2015_RS06360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WM2015_RS06385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WM2015_RS06410	COG0515	serine threonine protein kinase
WM2015_RS06410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WM2015_RS06415	COG3064	Membrane
WM2015_RS06430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WM2015_RS06440	COG3046	protein related to deoxyribodipyrimidine photolyase
WM2015_RS06465	COG3842	ATPase activity
WM2015_RS06470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WM2015_RS06475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WM2015_RS06495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WM2015_RS06525	COG2878	Part of a membrane complex involved in electron transport
WM2015_RS06540	COG4657	Part of a membrane complex involved in electron transport
WM2015_RS06545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WM2015_RS06545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WM2015_RS06560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WM2015_RS06565	COG0723	plastoquinol--plastocyanin reductase activity
WM2015_RS06570	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WM2015_RS06575	COG2857	Cytochrome c1
WM2015_RS06580	COG0625	glutathione transferase activity
WM2015_RS06585	COG2969	positive regulation of protein catabolic process
WM2015_RS06600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WM2015_RS06610	COG1238	metal cluster binding
WM2015_RS06620	COG1959	2 iron, 2 sulfur cluster binding
WM2015_RS06625	COG0860	N-Acetylmuramoyl-L-alanine amidase
WM2015_RS06630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WM2015_RS06635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WM2015_RS06640	COG1923	regulation of RNA biosynthetic process
WM2015_RS06645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WM2015_RS06650	COG0330	HflC and HflK could
WM2015_RS06655	COG0330	HflC and HflK could
WM2015_RS06660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WM2015_RS06665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WM2015_RS06670	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WM2015_RS06675	COG1605	Chorismate mutase
WM2015_RS06675	COG0077	Prephenate dehydratase
WM2015_RS06680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WM2015_RS06685	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WM2015_RS06690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WM2015_RS06695	COG0539	negative regulation of cytoplasmic translation
WM2015_RS06700	COG0776	regulation of translation
WM2015_RS06710	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WM2015_RS06715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WM2015_RS06745	COG1960	acyl-CoA dehydrogenase activity
WM2015_RS06750	COG0508	dehydrogenase complex catalyzes the overall conversion of
WM2015_RS06750	COG0022	dehydrogenase e1 component
WM2015_RS06755	COG4943	cyclic-guanylate-specific phosphodiesterase activity
WM2015_RS06770	COG0156	8-amino-7-oxononanoate synthase activity
WM2015_RS06775	COG1063	alcohol dehydrogenase
WM2015_RS06795	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WM2015_RS06810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WM2015_RS06815	COG1472	Belongs to the glycosyl hydrolase 3 family
WM2015_RS06820	COG0668	transmembrane transport
WM2015_RS06830	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
WM2015_RS06855	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WM2015_RS06860	COG1546	Belongs to the CinA family
WM2015_RS06865	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
WM2015_RS06870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WM2015_RS06875	COG2137	regulation of response to DNA damage stimulus
WM2015_RS06880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WM2015_RS06890	COG0662	Cupin 2, conserved barrel domain protein
WM2015_RS06900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WM2015_RS06905	COG0516	GMP reductase activity
WM2015_RS06905	COG0517	IMP dehydrogenase activity
WM2015_RS06910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WM2015_RS06910	COG0519	Catalyzes the synthesis of GMP from XMP
WM2015_RS06940	COG1960	acyl-CoA dehydrogenase activity
WM2015_RS06945	COG2902	Dehydrogenase
WM2015_RS06965	COG0402	S-adenosylhomocysteine deaminase activity
WM2015_RS06980	COG3706	GGDEF domain
WM2015_RS06985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WM2015_RS06990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WM2015_RS07005	COG4943	cyclic-guanylate-specific phosphodiesterase activity
WM2015_RS07020	COG3590	peptidase
WM2015_RS07025	COG2770	Histidine kinase
WM2015_RS07025	COG3437	response regulator, receiver
WM2015_RS07040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WM2015_RS07045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WM2015_RS07050	COG4988	ABC transporter
WM2015_RS07055	COG1294	oxidase, subunit
WM2015_RS07060	COG1271	oxidase subunit
WM2015_RS07065	COG0432	Pfam Uncharacterised protein family UPF0047
WM2015_RS07075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WM2015_RS07085	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WM2015_RS07095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WM2015_RS07100	COG1288	antiporter activity
WM2015_RS07110	COG0626	cystathionine gamma-synthase activity
WM2015_RS07115	COG1522	sequence-specific DNA binding
WM2015_RS07145	COG2915	High frequency lysogenization protein hflD homolog
WM2015_RS07150	COG0482	sulfurtransferase activity
WM2015_RS07155	COG0583	DNA-binding transcription factor activity
WM2015_RS07160	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WM2015_RS07165	COG2224	Isocitrate lyase
WM2015_RS07170	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WM2015_RS07175	COG0542	response to heat
WM2015_RS07180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WM2015_RS07185	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
WM2015_RS07215	COG2235	arginine
WM2015_RS07220	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WM2015_RS07235	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WM2015_RS07240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WM2015_RS07245	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
WM2015_RS07255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WM2015_RS07260	COG0071	Belongs to the small heat shock protein (HSP20) family
WM2015_RS07285	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WM2015_RS07295	COG0492	ferredoxin-NADP+ reductase activity
WM2015_RS07300	COG0686	Belongs to the AlaDH PNT family
WM2015_RS07305	COG1674	ftsk spoiiie
WM2015_RS07310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WM2015_RS07340	COG1132	(ABC) transporter
WM2015_RS07360	COG2197	response regulator
WM2015_RS07415	COG0662	Cupin 2, conserved barrel domain protein
WM2015_RS07435	COG0017	Asparaginyl-tRNA synthetase
WM2015_RS07440	COG0316	Belongs to the HesB IscA family
WM2015_RS07450	COG0360	Binds together with S18 to 16S ribosomal RNA
WM2015_RS07455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WM2015_RS07465	COG0305	Participates in initiation and elongation during chromosome replication
WM2015_RS07470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WM2015_RS07475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WM2015_RS07480	COG1702	phosphate starvation-inducible protein PhoH
WM2015_RS07485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WM2015_RS07490	COG4535	Mg2 and Co2 transporter CorC
WM2015_RS07520	COG1064	alcohol dehydrogenase
WM2015_RS07530	COG3228	Belongs to the MtfA family
WM2015_RS07535	COG1022	Amp-dependent synthetase and ligase
WM2015_RS07545	COG1473	amidohydrolase
WM2015_RS07560	COG0463	Glycosyl transferase, family 2
WM2015_RS07575	COG0531	amino acid
WM2015_RS07595	COG0488	(ABC) transporter
WM2015_RS07615	COG3710	Transcriptional regulator
WM2015_RS07625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WM2015_RS07635	COG1047	Peptidyl-prolyl cis-trans
WM2015_RS07640	COG1850	ribulose-bisphosphate carboxylase activity
WM2015_RS07675	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
WM2015_RS07700	COG0793	Belongs to the peptidase S41A family
WM2015_RS07700	COG4946	Tricorn protease homolog
WM2015_RS07705	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WM2015_RS07705	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WM2015_RS07710	COG0109	protoheme IX farnesyltransferase activity
WM2015_RS07715	COG1612	heme a metabolic process
WM2015_RS07735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WM2015_RS07735	COG0678	peroxiredoxin activity
WM2015_RS07745	COG0604	alcohol dehydrogenase
WM2015_RS07765	COG2850	peptidyl-arginine hydroxylation
WM2015_RS07780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WM2015_RS07800	COG1162	GTPase activity
WM2015_RS07805	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WM2015_RS07815	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WM2015_RS07825	COG0505	Belongs to the CarA family
WM2015_RS07830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WM2015_RS07835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WM2015_RS07845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WM2015_RS07855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WM2015_RS07870	COG0124	histidyl-tRNA synthetase
WM2015_RS07875	COG2976	Protein conserved in bacteria
WM2015_RS07880	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM2015_RS07885	COG1160	GTP binding
WM2015_RS07890	COG0386	Belongs to the glutathione peroxidase family
WM2015_RS07895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WM2015_RS07905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
WM2015_RS07920	COG0183	Belongs to the thiolase family
WM2015_RS07930	COG0424	maF-like protein
WM2015_RS07935	COG1399	metal-binding, possibly nucleic acid-binding protein
WM2015_RS07940	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WM2015_RS07950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WM2015_RS07970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WM2015_RS07975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WM2015_RS07980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WM2015_RS07985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WM2015_RS07990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WM2015_RS08005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WM2015_RS08010	COG0318	PFAM AMP-dependent synthetase and ligase
WM2015_RS08025	COG1201	RNA secondary structure unwinding
WM2015_RS08035	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WM2015_RS08040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WM2015_RS08045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WM2015_RS08060	COG3409	Peptidoglycan-binding domain 1 protein
WM2015_RS08060	COG3267	Type II secretory pathway component ExeA
WM2015_RS08080	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WM2015_RS08085	COG2861	carbohydrate metabolic process
WM2015_RS08090	COG0793	Belongs to the peptidase S41A family
WM2015_RS08095	COG4942	peptidase
WM2015_RS08100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WM2015_RS08105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WM2015_RS08110	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WM2015_RS08115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WM2015_RS08120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WM2015_RS08125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WM2015_RS08185	COG0628	permease
WM2015_RS08195	COG1757	Na H antiporter
WM2015_RS08205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WM2015_RS08215	COG0326	Molecular chaperone. Has ATPase activity
WM2015_RS08245	COG0336	Belongs to the RNA methyltransferase TrmD family
WM2015_RS08250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WM2015_RS08255	COG0228	four-way junction DNA binding
WM2015_RS08270	COG0405	Gamma-glutamyltransferase
WM2015_RS08275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WM2015_RS08280	COG0742	ribosomal rna small subunit methyltransferase
WM2015_RS08285	COG0552	protein localization to endoplasmic reticulum
WM2015_RS08290	COG1194	a g-specific adenine glycosylase
WM2015_RS08300	COG4585	Histidine kinase
WM2015_RS08310	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WM2015_RS08335	COG0237	dephospho-CoA kinase activity
WM2015_RS08340	COG0589	response to stress
WM2015_RS08345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WM2015_RS08360	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WM2015_RS08375	COG2350	Protein conserved in bacteria
WM2015_RS08380	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WM2015_RS08385	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WM2015_RS08405	COG0557	exoribonuclease II activity
WM2015_RS08410	COG1388	LysM domain
WM2015_RS08410	COG0741	lytic transglycosylase activity
WM2015_RS08425	COG1469	GTP cyclohydrolase I activity
WM2015_RS08445	COG0072	phenylalanine-tRNA ligase activity
WM2015_RS08445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WM2015_RS08460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WM2015_RS08465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WM2015_RS08470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WM2015_RS08510	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM2015_RS08540	COG0500	methyltransferase
WM2015_RS08555	COG1253	flavin adenine dinucleotide binding
WM2015_RS08575	COG0823	Involved in the tonB-independent uptake of proteins
WM2015_RS08575	COG4946	Tricorn protease homolog
WM2015_RS08575	COG1506	peptidase
WM2015_RS08580	COG0277	FAD linked oxidase domain protein
WM2015_RS08585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WM2015_RS08595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WM2015_RS08600	COG0714	Associated with various cellular activities
WM2015_RS08605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WM2015_RS08610	COG0537	adenosine 5'-monophosphoramidase activity
WM2015_RS08635	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WM2015_RS08650	COG0402	S-adenosylhomocysteine deaminase activity
WM2015_RS08655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WM2015_RS08660	COG1509	lysine 2,3-aminomutase activity
WM2015_RS08670	COG0501	Belongs to the peptidase M48B family
WM2015_RS08675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WM2015_RS08680	COG0825	malonyl-CoA metabolic process
WM2015_RS08685	COG0037	tRNA processing
WM2015_RS08720	COG0456	acetyltransferase
WM2015_RS08735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WM2015_RS08740	COG0156	8-amino-7-oxononanoate synthase activity
WM2015_RS08745	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WM2015_RS08765	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WM2015_RS08770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WM2015_RS08800	COG2133	pyrroloquinoline quinone binding
WM2015_RS08815	COG3153	acetyltransferase
WM2015_RS08815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WM2015_RS08820	COG0438	transferase activity, transferring glycosyl groups
WM2015_RS08825	COG1570	exodeoxyribonuclease VII activity
WM2015_RS08840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WM2015_RS08845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WM2015_RS08850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WM2015_RS08855	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WM2015_RS08870	COG1960	acyl-CoA dehydrogenase activity
WM2015_RS08875	COG1607	acyl-coa hydrolase
WM2015_RS08880	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WM2015_RS08885	COG0450	alkyl hydroperoxide reductase
WM2015_RS08890	COG0583	DNA-binding transcription factor activity
WM2015_RS08910	COG1131	(ABC) transporter
WM2015_RS08945	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WM2015_RS08950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WM2015_RS08955	COG0372	Belongs to the citrate synthase family
WM2015_RS08960	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WM2015_RS08965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM2015_RS08965	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WM2015_RS08980	COG0714	Associated with various cellular activities
WM2015_RS08995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WM2015_RS09000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WM2015_RS09005	COG2833	Protein of unknown function (DUF455)
WM2015_RS09060	COG0745	RESPONSE REGULATOR receiver
WM2015_RS09065	COG0527	aspartate kinase activity
WM2015_RS09065	COG0460	homoserine dehydrogenase
WM2015_RS09070	COG0626	cystathionine gamma-synthase activity
WM2015_RS09075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WM2015_RS09090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WM2015_RS09100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WM2015_RS09110	COG4221	oxidoreductase activity
WM2015_RS09150	COG3483	tryptophan 2,3-dioxygenase activity
WM2015_RS09160	COG0022	dehydrogenase e1 component
WM2015_RS09165	COG0508	dehydrogenase complex catalyzes the overall conversion of
WM2015_RS09170	COG4067	protein conserved in archaea
WM2015_RS09170	COG0189	ligase activity
WM2015_RS09175	COG0189	ligase activity
WM2015_RS09205	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WM2015_RS09235	COG0322	excinuclease ABC activity
WM2015_RS09240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WM2015_RS09245	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WM2015_RS09255	COG1132	(ABC) transporter
WM2015_RS09260	COG0848	biopolymer transport protein
WM2015_RS09265	COG0811	peptide transport
WM2015_RS09270	COG0658	competence protein
WM2015_RS09270	COG2333	competence protein COMEC
WM2015_RS09275	COG1136	(ABC) transporter
WM2015_RS09280	COG4591	ABC-type transport system involved in lipoprotein release permease component
WM2015_RS09290	COG1530	ribonuclease E activity
WM2015_RS09295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WM2015_RS09300	COG0484	heat shock protein binding
WM2015_RS09310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WM2015_RS09315	COG0497	DNA recombination
WM2015_RS09325	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM2015_RS09330	COG2914	Belongs to the UPF0125 (RnfH) family
WM2015_RS09340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WM2015_RS09345	COG0582	viral genome integration into host DNA
WM2015_RS09350	COG2801	Transposase and inactivated derivatives
WM2015_RS09365	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
WM2015_RS09370	COG2226	methyltransferase
WM2015_RS09390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WM2015_RS09390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WM2015_RS09400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WM2015_RS09405	COG0704	Plays a role in the regulation of phosphate uptake
WM2015_RS09410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WM2015_RS09415	COG0573	inorganic phosphate transmembrane transporter activity
WM2015_RS09450	COG0848	biopolymer transport protein
WM2015_RS09455	COG0811	peptide transport
WM2015_RS09460	COG0811	peptide transport
WM2015_RS09485	COG0735	belongs to the Fur family
WM2015_RS09495	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WM2015_RS09505	COG0328	RNA-DNA hybrid ribonuclease activity
WM2015_RS09515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WM2015_RS09555	COG4969	Belongs to the N-Me-Phe pilin family
WM2015_RS09595	COG3118	belongs to the thioredoxin family
WM2015_RS09600	COG0513	Belongs to the DEAD box helicase family
WM2015_RS09605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WM2015_RS09620	COG1459	type II secretion system
WM2015_RS09625	COG2884	Cell division ATP-binding protein ftsE
WM2015_RS09630	COG2177	Part of the ABC transporter FtsEX involved in
WM2015_RS09635	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WM2015_RS09655	COG0642	Histidine kinase
WM2015_RS09660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WM2015_RS09670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WM2015_RS09705	COG1250	3-hydroxyacyl-CoA dehydrogenase
WM2015_RS09705	COG1024	Enoyl-CoA hydratase
WM2015_RS09710	COG0183	Belongs to the thiolase family
WM2015_RS09730	COG2815	serine threonine protein kinase
WM2015_RS09730	COG0515	serine threonine protein kinase
WM2015_RS09745	COG1960	acyl-CoA dehydrogenase activity
WM2015_RS09755	COG1946	Acyl-CoA thioesterase
WM2015_RS09765	COG1217	gtp-binding protein TYPA
WM2015_RS09770	COG3071	HemY protein
WM2015_RS09785	COG0181	hydroxymethylbilane synthase activity
WM2015_RS09800	COG4106	trans-aconitate 2-methyltransferase activity
WM2015_RS09805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WM2015_RS09815	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
WM2015_RS09825	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WM2015_RS09830	COG1127	ABC transporter
WM2015_RS09835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WM2015_RS09840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WM2015_RS09860	COG5001	Diguanylate cyclase
WM2015_RS09860	COG3300	MHYT domain
WM2015_RS09865	COG0640	Transcriptional regulator
WM2015_RS09875	COG1410	methionine synthase
WM2015_RS09875	COG0646	methionine synthase
WM2015_RS09900	COG1131	(ABC) transporter
WM2015_RS09920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WM2015_RS09940	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
WM2015_RS09955	COG0436	Aminotransferase
WM2015_RS09965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WM2015_RS09965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WM2015_RS09970	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WM2015_RS10010	COG0039	L-malate dehydrogenase activity
WM2015_RS10015	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
WM2015_RS10030	COG1012	belongs to the aldehyde dehydrogenase family
WM2015_RS10045	COG1597	lipid kinase activity
WM2015_RS10050	COG4771	TonB-dependent receptor
WM2015_RS10075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WM2015_RS10085	COG1902	pentaerythritol trinitrate reductase activity
WM2015_RS10085	COG0446	pyridine nucleotide-disulphide oxidoreductase
WM2015_RS10090	COG2133	pyrroloquinoline quinone binding
WM2015_RS10095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WM2015_RS10100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WM2015_RS10105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WM2015_RS10165	COG1842	Phage shock protein A
WM2015_RS10185	COG1024	Enoyl-CoA hydratase
WM2015_RS10210	COG1091	dTDP-4-dehydrorhamnose reductase activity
WM2015_RS10235	COG0142	geranyltranstransferase activity
WM2015_RS10260	COG0473	3-isopropylmalate dehydrogenase activity
WM2015_RS10285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WM2015_RS10290	COG0248	Ppx GppA phosphatase
WM2015_RS10295	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
WM2015_RS10310	COG0415	Belongs to the DNA photolyase family
WM2015_RS10325	COG1286	toxin biosynthetic process
WM2015_RS10335	COG0285	dihydrofolate synthase activity
WM2015_RS10340	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WM2015_RS10345	COG0159	tryptophan synthase activity
WM2015_RS10350	COG0133	tryptophan synthase activity
WM2015_RS10355	COG0135	phosphoribosylanthranilate isomerase activity
WM2015_RS10360	COG0101	tRNA pseudouridine synthase activity
WM2015_RS10370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WM2015_RS10375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WM2015_RS10390	COG4181	ATPase activity
WM2015_RS10415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WM2015_RS10440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WM2015_RS10445	COG0339	signal peptide processing
WM2015_RS10450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WM2015_RS10455	COG4137	Cytochrome C assembly protein
WM2015_RS10460	COG4536	flavin adenine dinucleotide binding
WM2015_RS10480	COG1381	Involved in DNA repair and RecF pathway recombination
WM2015_RS10490	COG0571	ribonuclease III activity
WM2015_RS10500	COG0681	Belongs to the peptidase S26 family
WM2015_RS10505	COG0481	GTPase activity
WM2015_RS10510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WM2015_RS10535	COG1012	belongs to the aldehyde dehydrogenase family
WM2015_RS10540	COG0167	dihydroorotate dehydrogenase activity
WM2015_RS10545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WM2015_RS10560	COG1505	serine-type exopeptidase activity
WM2015_RS10570	COG2855	membrane
WM2015_RS10575	COG0527	aspartate kinase activity
WM2015_RS10575	COG0460	homoserine dehydrogenase
WM2015_RS10585	COG2968	Membrane
WM2015_RS10590	COG2217	Heavy metal translocating P-type atpase
WM2015_RS10680	COG2986	histidine ammonia-lyase
WM2015_RS10685	COG1228	amidohydrolase
WM2015_RS10710	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WM2015_RS10715	COG1862	Preprotein translocase
WM2015_RS10735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WM2015_RS10745	COG2815	serine threonine protein kinase
WM2015_RS10745	COG0515	serine threonine protein kinase
WM2015_RS10755	COG0343	queuine tRNA-ribosyltransferase activity
WM2015_RS10760	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WM2015_RS10780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WM2015_RS10800	COG1404	Belongs to the peptidase S8 family
WM2015_RS10810	COG4133	protoheme IX ABC transporter activity
WM2015_RS10815	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WM2015_RS10820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WM2015_RS10825	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WM2015_RS10830	COG1138	Cytochrome C-type biogenesis protein
WM2015_RS10835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WM2015_RS10850	COG1392	Phosphate transport regulator
WM2015_RS10855	COG0306	phosphate transporter
WM2015_RS10880	COG0268	Binds directly to 16S ribosomal RNA
WM2015_RS10890	COG0741	lytic transglycosylase activity
WM2015_RS10905	COG2925	Exonuclease
WM2015_RS10915	COG1596	polysaccharide export
WM2015_RS10915	COG1555	photosystem II stabilization
WM2015_RS10920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WM2015_RS10925	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WM2015_RS10930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WM2015_RS10935	COG1404	Belongs to the peptidase S8 family
WM2015_RS10940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WM2015_RS10945	COG1704	LemA family
WM2015_RS10965	COG3012	SEC-C Motif Domain Protein
WM2015_RS10965	COG3318	Belongs to the UPF0149 family
WM2015_RS11025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM2015_RS11090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WM2015_RS11125	COG1671	Belongs to the UPF0178 family
WM2015_RS11135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WM2015_RS11160	COG0183	Belongs to the thiolase family
WM2015_RS11185	COG0668	transmembrane transport
WM2015_RS11200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WM2015_RS11230	COG0515	serine threonine protein kinase
WM2015_RS11260	COG0688	phosphatidylethanolamine metabolic process
WM2015_RS11275	COG2738	Putative neutral zinc metallopeptidase
WM2015_RS11290	COG0792	nuclease activity
WM2015_RS11300	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WM2015_RS11310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WM2015_RS11315	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WM2015_RS11330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WM2015_RS11330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WM2015_RS11335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WM2015_RS11340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WM2015_RS11370	COG2197	response regulator
WM2015_RS11375	COG3239	Fatty acid desaturase
WM2015_RS11395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WM2015_RS11410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WM2015_RS11415	COG4464	protein tyrosine phosphatase activity
WM2015_RS11430	COG1272	protein, Hemolysin III
WM2015_RS11440	COG1132	(ABC) transporter
WM2015_RS11445	COG2962	Rard protein
WM2015_RS11455	COG0203	ribosomal protein L17
WM2015_RS11465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WM2015_RS11475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WM2015_RS11480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WM2015_RS11485	COG0201	protein transport
WM2015_RS11490	COG0200	Binds to the 23S rRNA
WM2015_RS11495	COG1841	ribosomal large subunit assembly
WM2015_RS11505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WM2015_RS11510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WM2015_RS11515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WM2015_RS11520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WM2015_RS11525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WM2015_RS11530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WM2015_RS11540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WM2015_RS11545	COG0255	Belongs to the universal ribosomal protein uL29 family
WM2015_RS11555	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WM2015_RS11560	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WM2015_RS11565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WM2015_RS11570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WM2015_RS11575	COG0089	rRNA binding
WM2015_RS11580	COG0088	Forms part of the polypeptide exit tunnel
WM2015_RS11585	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WM2015_RS11590	COG0051	transcription antitermination factor activity, RNA binding
WM2015_RS11595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WM2015_RS11600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WM2015_RS11610	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WM2015_RS11650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WM2015_RS11655	COG0085	RNA polymerase activity
WM2015_RS11660	COG0222	ribosome binding
WM2015_RS11665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WM2015_RS11670	COG0081	regulation of translation
WM2015_RS11675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WM2015_RS11685	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WM2015_RS11695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WM2015_RS11715	COG0012	GTP binding
WM2015_RS11720	COG0193	aminoacyl-tRNA hydrolase activity
WM2015_RS11725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WM2015_RS11745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WM2015_RS11750	COG0196	riboflavin kinase activity
WM2015_RS11770	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_RS11795	COG2866	Carboxypeptidase
WM2015_RS11800	COG0564	pseudouridine synthase activity
WM2015_RS11815	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WM2015_RS11840	COG0642	Histidine kinase
WM2015_RS11845	COG0745	RESPONSE REGULATOR receiver
WM2015_RS11880	COG0625	glutathione transferase activity
WM2015_RS11905	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WM2015_RS11930	COG2091	lysine biosynthetic process via aminoadipic acid
WM2015_RS11935	COG0494	nUDIX hydrolase
WM2015_RS11940	COG0653	protein targeting
WM2015_RS11950	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WM2015_RS11965	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WM2015_RS11970	COG1181	Belongs to the D-alanine--D-alanine ligase family
WM2015_RS11980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WM2015_RS11990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WM2015_RS11995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WM2015_RS12000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WM2015_RS12010	COG3116	cell division
WM2015_RS12015	COG0275	rRNA processing
WM2015_RS12020	COG2001	Belongs to the MraZ family
WM2015_RS12025	COG1611	Belongs to the LOG family
WM2015_RS12040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WM2015_RS12080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WM2015_RS12085	COG0438	transferase activity, transferring glycosyl groups
WM2015_RS12090	COG3394	polysaccharide catabolic process
WM2015_RS12095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WM2015_RS12115	COG0438	transferase activity, transferring glycosyl groups
WM2015_RS12130	COG2244	polysaccharide biosynthetic process
WM2015_RS12135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WM2015_RS12160	COG0489	protein tyrosine kinase activity
WM2015_RS12175	COG1943	Transposase
WM2015_RS12180	COG2198	Histidine kinase
WM2015_RS12180	COG2205	protein histidine kinase activity
WM2015_RS12180	COG0784	Response regulator, receiver
WM2015_RS12190	COG2610	gluconate transmembrane transporter activity
WM2015_RS12200	COG0626	cystathionine gamma-synthase activity
WM2015_RS12210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WM2015_RS12215	COG0596	Alpha beta hydrolase
WM2015_RS12220	COG0318	PFAM AMP-dependent synthetase and ligase
WM2015_RS12235	COG0585	pseudouridine synthase activity
WM2015_RS12245	COG0745	RESPONSE REGULATOR receiver
WM2015_RS12255	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WM2015_RS12260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WM2015_RS12280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WM2015_RS12285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM2015_RS12295	COG1660	Displays ATPase and GTPase activities
WM2015_RS12310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WM2015_RS12330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WM2015_RS12335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WM2015_RS12340	COG0195	Participates in both transcription termination and antitermination
WM2015_RS12340	COG2251	uridine kinase activity
WM2015_RS12385	COG4935	Belongs to the peptidase S8 family
WM2015_RS12385	COG2234	aminopeptidase activity
WM2015_RS12395	COG0515	serine threonine protein kinase
WM2015_RS12395	COG2815	serine threonine protein kinase
WM2015_RS12405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WM2015_RS12410	COG0719	Fe-S assembly protein
WM2015_RS12415	COG0396	ATPase activity
WM2015_RS12425	COG0719	Fe-S assembly protein
WM2015_RS12430	COG1959	2 iron, 2 sulfur cluster binding
WM2015_RS12445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WM2015_RS12460	COG0367	asparagine synthase
WM2015_RS12465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WM2015_RS12470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WM2015_RS12480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WM2015_RS12485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WM2015_RS12495	COG0501	Belongs to the peptidase M48B family
WM2015_RS12520	COG0308	aminopeptidase N
WM2015_RS12525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WM2015_RS12535	COG1956	GAF domain-containing protein
WM2015_RS12545	COG0402	S-adenosylhomocysteine deaminase activity
WM2015_RS12615	COG1115	amino acid carrier protein
WM2015_RS12630	COG0616	signal peptide processing
WM2015_RS12635	COG0534	Mate efflux family protein
WM2015_RS12645	COG2815	serine threonine protein kinase
WM2015_RS12645	COG0515	serine threonine protein kinase
WM2015_RS12675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WM2015_RS12675	COG3218	ABC-type transport auxiliary lipoprotein component
WM2015_RS12680	COG1127	ABC transporter
WM2015_RS12695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WM2015_RS12710	COG1652	LysM domain
WM2015_RS12715	COG2205	protein histidine kinase activity
WM2015_RS12715	COG2198	Histidine kinase
WM2015_RS12715	COG0784	Response regulator, receiver
WM2015_RS12725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WM2015_RS12740	COG2176	DNA-directed DNA polymerase activity
WM2015_RS12740	COG5002	protein histidine kinase activity
WM2015_RS12745	COG0516	GMP reductase activity
WM2015_RS12745	COG0517	IMP dehydrogenase activity
WM2015_RS12755	COG0515	serine threonine protein kinase
WM2015_RS12815	COG2945	thiolester hydrolase activity
WM2015_RS12820	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WM2015_RS12835	COG1960	acyl-CoA dehydrogenase activity
WM2015_RS12845	COG1477	protein flavinylation
WM2015_RS12885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WM2015_RS12890	COG1120	ATPase activity
WM2015_RS12895	COG2308	Evidence 4 Homologs of previously reported genes of
WM2015_RS12915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM2015_RS12925	COG3300	MHYT domain
WM2015_RS12925	COG5001	Diguanylate cyclase
WM2015_RS12930	COG0617	tRNA 3'-terminal CCA addition
WM2015_RS12940	COG0741	lytic transglycosylase activity
WM2015_RS12945	COG0730	response to heat
WM2015_RS12965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WM2015_RS12975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WM2015_RS13025	COG0084	hydrolase, TatD family'
WM2015_RS13030	COG3256	nitric oxide reductase
WM2015_RS13035	COG2832	Protein of unknown function (DUF454)
WM2015_RS13045	COG1959	2 iron, 2 sulfur cluster binding
WM2015_RS13060	COG0848	biopolymer transport protein
WM2015_RS13065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WM2015_RS13085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WM2015_RS13095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
WM2015_RS13105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WM2015_RS13115	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_RS13145	COG2409	Drug exporters of the RND superfamily
WM2015_RS13190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WM2015_RS13225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WM2015_RS13230	COG2815	serine threonine protein kinase
WM2015_RS13230	COG0515	serine threonine protein kinase
WM2015_RS13245	COG0508	dehydrogenase complex catalyzes the overall conversion of
WM2015_RS13255	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
WM2015_RS13270	COG3588	fructose-bisphosphate aldolase
WM2015_RS13275	COG0469	pyruvate kinase activity
WM2015_RS13280	COG0625	glutathione transferase activity
WM2015_RS13285	COG2356	endonuclease I
WM2015_RS13300	COG5642	Protein of unknown function (DUF2384)
WM2015_RS13305	COG1476	TRANSCRIPTIONal
WM2015_RS13365	COG0463	Glycosyl transferase, family 2
WM2015_RS13395	COG0501	Belongs to the peptidase M48B family
WM2015_RS13410	COG3300	MHYT domain
WM2015_RS13410	COG5001	Diguanylate cyclase
WM2015_RS13460	COG3425	synthase
WM2015_RS13485	COG4774	siderophore transport
WM2015_RS13505	COG2850	peptidyl-arginine hydroxylation
WM2015_RS13530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WM2015_RS13595	COG1944	ATP diphosphatase activity
WM2015_RS13605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WM2015_RS13610	COG3118	belongs to the thioredoxin family
WM2015_RS13655	COG0126	phosphoglycerate kinase activity
WM2015_RS13660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WM2015_RS13665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WM2015_RS13685	COG0642	Histidine kinase
WM2015_RS13715	COG0762	integral membrane protein
WM2015_RS13740	COG0347	Belongs to the P(II) protein family
WM2015_RS13750	COG5002	protein histidine kinase activity
WM2015_RS13750	COG5001	Diguanylate cyclase
WM2015_RS13755	COG0606	chelatase, subunit chli
WM2015_RS13770	COG1575	Belongs to the MenA family. Type 1 subfamily
WM2015_RS13800	COG0519	Catalyzes the synthesis of GMP from XMP
WM2015_RS13830	COG3132	Protein of unknown function, DUF480
WM2015_RS13835	COG1278	Cold shock
WM2015_RS13855	COG2203	Gaf domain
WM2015_RS13855	COG2199	diguanylate cyclase activity
WM2015_RS13855	COG2200	EAL domain
WM2015_RS13870	COG1160	GTP binding
WM2015_RS13880	COG3278	Belongs to the heme-copper respiratory oxidase family
WM2015_RS13890	COG2010	Cytochrome c
WM2015_RS13910	COG2217	Heavy metal translocating P-type atpase
WM2015_RS13955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WM2015_RS13985	COG0174	glutamine synthetase
WM2015_RS13995	COG3852	Histidine kinase
WM2015_RS14000	COG2204	response regulator
WM2015_RS14005	COG1490	D-aminoacyl-tRNA deacylase activity
WM2015_RS14015	COG3360	Dodecin
WM2015_RS14020	COG0501	Belongs to the peptidase M48B family
WM2015_RS14025	COG1704	LemA family
WM2015_RS14050	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
WM2015_RS14060	COG2815	serine threonine protein kinase
WM2015_RS14060	COG0515	serine threonine protein kinase
WM2015_RS14100	COG3604	Transcriptional regulator
WM2015_RS14105	COG2815	serine threonine protein kinase
WM2015_RS14105	COG0515	serine threonine protein kinase
WM2015_RS14135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
WM2015_RS14165	COG0640	Transcriptional regulator
WM2015_RS14170	COG0739	heme binding
WM2015_RS14175	COG1760	l-serine dehydratase
WM2015_RS14185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM2015_RS14205	COG1461	Dihydroxyacetone kinase
WM2015_RS14210	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WM2015_RS14215	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WM2015_RS14215	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WM2015_RS14220	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
WM2015_RS14230	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WM2015_RS14235	COG1040	competence protein
WM2015_RS14240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WM2015_RS14245	COG0156	8-amino-7-oxononanoate synthase activity
WM2015_RS14320	COG4221	oxidoreductase activity
WM2015_RS14330	COG0415	Belongs to the DNA photolyase family
WM2015_RS14345	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
WM2015_RS14460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WM2015_RS14475	COG3668	Plasmid stabilization system
WM2015_RS14480	COG3609	addiction module antidote protein, CC2985 family
WM2015_RS14485	COG2226	methyltransferase
WM2015_RS14515	COG0750	zinc metalloprotease
WM2015_RS14540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WM2015_RS14550	COG0330	HflC and HflK could
WM2015_RS14570	COG1741	Belongs to the pirin family
WM2015_RS14575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WM2015_RS14580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WM2015_RS14590	COG3268	Saccharopine dehydrogenase
WM2015_RS14595	COG0418	dihydroorotase activity
WM2015_RS14605	COG1597	lipid kinase activity
WM2015_RS14620	COG1666	GTP binding
WM2015_RS14625	COG0204	Acyl-transferase
WM2015_RS14630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WM2015_RS14635	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_RS14645	COG1960	acyl-CoA dehydrogenase activity
WM2015_RS14675	COG0393	Putative heavy-metal-binding
WM2015_RS14695	COG0277	FAD linked oxidase domain protein
WM2015_RS14735	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WM2015_RS14795	COG2354	Protein conserved in bacteria
WM2015_RS14800	COG0346	lactoylglutathione lyase activity
WM2015_RS14810	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
WM2015_RS14840	COG0297	glycogen (starch) synthase activity
WM2015_RS14915	COG1166	arginine decarboxylase activity
WM2015_RS14920	COG2084	Dehydrogenase
WM2015_RS14940	COG1115	amino acid carrier protein
WM2015_RS14960	COG0018	arginyl-trna synthetase
WM2015_RS14965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WM2015_RS14970	COG0656	L-ascorbic acid biosynthetic process
WM2015_RS14980	COG1404	Belongs to the peptidase S8 family
WM2015_RS14985	COG1404	Belongs to the peptidase S8 family
WM2015_RS15000	COG0842	Transport permease protein
WM2015_RS15005	COG1131	(ABC) transporter
WM2015_RS15015	COG4555	ABC transporter
WM2015_RS15020	COG1668	transmembrane transport
WM2015_RS15030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WM2015_RS15060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WM2015_RS15065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WM2015_RS15070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WM2015_RS15075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WM2015_RS15075	COG0131	Imidazoleglycerol-phosphate dehydratase
WM2015_RS15085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WM2015_RS15100	COG2199	diguanylate cyclase activity
WM2015_RS15100	COG2200	EAL domain
WM2015_RS15115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WM2015_RS15130	COG0579	oxidoreductase
WM2015_RS15160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WM2015_RS15185	COG1028	Short-chain dehydrogenase reductase Sdr
WM2015_RS15190	COG2311	Membrane
WM2015_RS15255	COG1794	racemase activity, acting on amino acids and derivatives
WM2015_RS15260	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
WM2015_RS15280	COG4585	Histidine kinase
WM2015_RS15375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WM2015_RS15385	COG1773	rubredoxin
WM2015_RS15390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
WM2015_RS15400	COG0210	DNA helicase
WM2015_RS15415	COG5001	Diguanylate cyclase
WM2015_RS15415	COG2203	Gaf domain
WM2015_RS15415	COG3706	GGDEF domain
WM2015_RS15415	COG4251	negative regulation of phosphorylation
WM2015_RS15420	COG0583	DNA-binding transcription factor activity
WM2015_RS15430	COG0435	Glutathione S-transferase
WM2015_RS15440	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WM2015_RS15445	COG0706	membrane insertase activity
WM2015_RS15450	COG0594	ribonuclease P activity
WM2015_RS15455	COG0230	Belongs to the bacterial ribosomal protein bL34 family