locus-tag	class	description
WGL_RS00010	COG0445	tRNA wobble uridine modification
WGL_RS00035	COG0445	tRNA wobble uridine modification
WGL_RS00040	COG0356	it plays a direct role in the translocation of protons across the membrane
WGL_RS00050	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WGL_RS00055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WGL_RS00060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WGL_RS00065	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WGL_RS00070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WGL_RS00075	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WGL_RS00080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WGL_RS00085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WGL_RS00090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WGL_RS00095	COG0706	membrane insertase activity
WGL_RS00100	COG0594	ribonuclease P activity
WGL_RS00105	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WGL_RS00115	COG0187	DNA topoisomerase II activity
WGL_RS00125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WGL_RS00130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WGL_RS00135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WGL_RS00140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WGL_RS00145	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
WGL_RS00150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WGL_RS00155	COG0505	Belongs to the CarA family
WGL_RS00160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WGL_RS00165	COG0628	permease
WGL_RS00170	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WGL_RS00175	COG0049	tRNA binding
WGL_RS00180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WGL_RS00210	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WGL_RS00225	COG1815	bacterial-type flagellum-dependent cell motility
WGL_RS00230	COG1558	bacterial-type flagellum-dependent cell motility
WGL_RS00235	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
WGL_RS00240	COG1749	Flagellar hook protein flgE
WGL_RS00245	COG4787	bacterial-type flagellum-dependent cell motility
WGL_RS00255	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WGL_RS00260	COG1706	bacterial-type flagellum-dependent cell motility
WGL_RS00265	COG3951	Flagellar rod assembly protein muramidase FlgJ
WGL_RS00290	COG1338	Plays a role in the flagellum-specific transport system
WGL_RS00295	COG3190	flagellar
WGL_RS00295	COG1338	Plays a role in the flagellum-specific transport system
WGL_RS00310	COG1580	Controls the rotational direction of flagella during chemotaxis
WGL_RS00315	COG3144	bacterial-type flagellum assembly
WGL_RS00335	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WGL_RS00340	COG1766	The M ring may be actively involved in energy transduction
WGL_RS00345	COG1677	Flagellar hook-basal body complex protein FliE
WGL_RS00365	COG1054	Belongs to the UPF0176 family
WGL_RS00370	COG2943	transferase activity, transferring hexosyl groups
WGL_RS00375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WGL_RS00380	COG0328	RNA-DNA hybrid ribonuclease activity
WGL_RS00385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WGL_RS00390	COG0742	ribosomal rna small subunit methyltransferase
WGL_RS00395	COG0552	protein localization to endoplasmic reticulum
WGL_RS00405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WGL_RS00410	COG0316	Belongs to the HesB IscA family
WGL_RS00415	COG0741	lytic transglycosylase activity
WGL_RS00420	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WGL_RS00435	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WGL_RS00440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WGL_RS00445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WGL_RS00450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WGL_RS00455	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WGL_RS00460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WGL_RS00465	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WGL_RS00470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WGL_RS00475	COG0072	phenylalanine-tRNA ligase activity
WGL_RS00480	COG0418	dihydroorotase activity
WGL_RS00485	COG1530	ribonuclease E activity
WGL_RS00495	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WGL_RS00500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WGL_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
WGL_RS00510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WGL_RS00515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WGL_RS00520	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WGL_RS00525	COG0470	DNA polymerase III
WGL_RS00530	COG0084	hydrolase, TatD family'
WGL_RS00535	COG0537	adenosine 5'-monophosphoramidase activity
WGL_RS00540	COG1252	NADH dehydrogenase
WGL_RS00545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WGL_RS00550	COG4591	ABC-type transport system involved in lipoprotein release permease component
WGL_RS00555	COG1136	(ABC) transporter
WGL_RS00560	COG4591	ABC-type transport system involved in lipoprotein release permease component
WGL_RS00565	COG4591	ABC-type transport system involved in lipoprotein release permease component
WGL_RS00570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WGL_RS00575	COG0482	sulfurtransferase activity
WGL_RS00580	COG0501	Belongs to the peptidase M48B family
WGL_RS00585	COG1253	flavin adenine dinucleotide binding
WGL_RS00590	COG0616	signal peptide processing
WGL_RS00595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WGL_RS00600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WGL_RS00605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WGL_RS00610	COG2867	negative regulation of translational initiation
WGL_RS00615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WGL_RS00620	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WGL_RS00625	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WGL_RS00630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WGL_RS00635	COG1121	(ABC) transporter
WGL_RS00640	COG0739	heme binding
WGL_RS00645	COG1914	H( )-stimulated, divalent metal cation uptake system
WGL_RS00660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WGL_RS00665	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WGL_RS00675	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
WGL_RS00710	COG1448	Aminotransferase
WGL_RS00715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WGL_RS00725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WGL_RS00735	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WGL_RS00740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WGL_RS00750	COG0018	arginyl-trna synthetase
WGL_RS00760	COG0167	dihydroorotate dehydrogenase activity
WGL_RS00765	COG0113	porphobilinogen synthase activity
WGL_RS00775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WGL_RS00780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WGL_RS00785	COG0306	phosphate transporter
WGL_RS00790	COG0469	pyruvate kinase activity
WGL_RS00800	COG0590	tRNA wobble adenosine to inosine editing
WGL_RS00805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WGL_RS00810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WGL_RS00815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WGL_RS00825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WGL_RS00830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WGL_RS00835	COG0142	geranyltranstransferase activity
WGL_RS00840	COG0301	tRNA thio-modification
WGL_RS00840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WGL_RS00845	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WGL_RS00850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WGL_RS00855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WGL_RS00860	COG1845	cytochrome c oxidase, subunit III
WGL_RS00865	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WGL_RS00870	COG0109	protoheme IX farnesyltransferase activity
WGL_RS00875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WGL_RS00880	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WGL_RS00885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WGL_RS00890	COG0740	serine-type endopeptidase activity
WGL_RS00895	COG0544	peptidyl-prolyl cis-trans isomerase activity
WGL_RS00900	COG2814	Major facilitator Superfamily
WGL_RS00905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WGL_RS00910	COG0463	Glycosyl transferase, family 2
WGL_RS00915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WGL_RS00915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WGL_RS00920	COG0726	polysaccharide deacetylase
WGL_RS00925	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
WGL_RS00935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WGL_RS00940	COG1678	Uncharacterized ACR, COG1678
WGL_RS00945	COG0189	ligase activity
WGL_RS00950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WGL_RS00955	COG0495	leucyl-tRNA aminoacylation
WGL_RS00965	COG1466	dna polymerase III delta subunit
WGL_RS00970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WGL_RS00975	COG0768	penicillin binding
WGL_RS00980	COG0772	Belongs to the SEDS family
WGL_RS00985	COG1686	Belongs to the peptidase S11 family
WGL_RS00990	COG0321	lipoyl(octanoyl) transferase activity
WGL_RS00995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WGL_RS01005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WGL_RS01010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WGL_RS01015	COG0280	phosphate acetyltransferase
WGL_RS01015	COG0857	belongs to the CobB CobQ family
WGL_RS01020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WGL_RS01025	COG0415	Belongs to the DNA photolyase family
WGL_RS01030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WGL_RS01035	COG1923	regulation of RNA biosynthetic process
WGL_RS01040	COG0330	HflC and HflK could
WGL_RS01045	COG0330	HflC and HflK could
WGL_RS01050	COG2814	Major facilitator Superfamily
WGL_RS01055	COG0765	amino acid transport
WGL_RS01060	COG0765	amino acid transport
WGL_RS01070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WGL_RS01075	COG0237	dephospho-CoA kinase activity
WGL_RS01080	COG0481	GTPase activity
WGL_RS01090	COG0571	ribonuclease III activity
WGL_RS01095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WGL_RS01100	COG0736	holo-[acyl-carrier-protein] synthase activity
WGL_RS01105	COG1191	sigma factor activity
WGL_RS01110	COG0653	protein targeting
WGL_RS01115	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WGL_RS01120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WGL_RS01125	COG0849	cell division
WGL_RS01135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WGL_RS01140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WGL_RS01145	COG0772	Belongs to the SEDS family
WGL_RS01150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WGL_RS01155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WGL_RS01160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WGL_RS01165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WGL_RS01170	COG0768	penicillin binding
WGL_RS01175	COG3116	cell division
WGL_RS01180	COG0275	rRNA processing
WGL_RS01185	COG1528	Iron-storage protein
WGL_RS01195	COG1181	Belongs to the D-alanine--D-alanine ligase family
WGL_RS01200	COG0588	phosphoglycerate mutase activity
WGL_RS01205	COG1132	(ABC) transporter
WGL_RS01210	COG1132	(ABC) transporter
WGL_RS01215	COG0513	Belongs to the DEAD box helicase family
WGL_RS01220	COG1185	polyribonucleotide nucleotidyltransferase activity
WGL_RS01225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WGL_RS01230	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WGL_RS01235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WGL_RS01240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WGL_RS01245	COG0195	Participates in both transcription termination and antitermination
WGL_RS01260	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WGL_RS01265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WGL_RS01270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WGL_RS01285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WGL_RS01300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WGL_RS01305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WGL_RS01310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WGL_RS01315	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WGL_RS01320	COG0617	tRNA 3'-terminal CCA addition
WGL_RS01325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WGL_RS01345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WGL_RS01350	COG0215	cysteine-tRNA ligase activity
WGL_RS01355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WGL_RS01360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WGL_RS01365	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WGL_RS01370	COG2918	glutathione biosynthetic process
WGL_RS01375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WGL_RS01380	COG0228	four-way junction DNA binding
WGL_RS01395	COG0335	large ribosomal subunit rRNA binding
WGL_RS01400	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WGL_RS01405	COG1663	tetraacyldisaccharide 4'-kinase activity
WGL_RS01410	COG1132	(ABC) transporter
WGL_RS01415	COG1862	Preprotein translocase
WGL_RS01420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WGL_RS01425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WGL_RS01430	COG0459	protein refolding
WGL_RS01435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WGL_RS01445	COG0359	binds to the 23S rRNA
WGL_RS01450	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WGL_RS01455	COG0360	Binds together with S18 to 16S ribosomal RNA
WGL_RS01460	COG0017	Asparaginyl-tRNA synthetase
WGL_RS01465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WGL_RS01470	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WGL_RS01475	COG1074	ATP-dependent DNA helicase activity
WGL_RS01490	COG0860	N-Acetylmuramoyl-L-alanine amidase
WGL_RS01500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WGL_RS01505	COG1011	Hydrolase
WGL_RS01510	COG0210	DNA helicase
WGL_RS01515	COG0598	Magnesium transport protein CorA
WGL_RS01520	COG0149	triose-phosphate isomerase activity
WGL_RS01525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WGL_RS01530	COG2814	Major facilitator Superfamily
WGL_RS01535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WGL_RS01540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WGL_RS01550	COG0254	rRNA binding
WGL_RS01555	COG1131	(ABC) transporter
WGL_RS01560	COG0842	Transport permease protein
WGL_RS01565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WGL_RS01580	COG0483	inositol monophosphate 1-phosphatase activity
WGL_RS01590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WGL_RS01595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WGL_RS01600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WGL_RS01605	COG1519	Transferase
WGL_RS01610	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WGL_RS01615	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WGL_RS01620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WGL_RS01625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WGL_RS01630	COG0196	riboflavin kinase activity
WGL_RS01635	COG0268	Binds directly to 16S ribosomal RNA
WGL_RS01640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WGL_RS01645	COG0484	heat shock protein binding
WGL_RS01650	COG0443	Heat shock 70 kDa protein
WGL_RS01655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WGL_RS01660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WGL_RS01680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WGL_RS01685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WGL_RS01690	COG3118	belongs to the thioredoxin family
WGL_RS01695	COG0126	phosphoglycerate kinase activity
WGL_RS01700	COG0191	fructose-bisphosphate aldolase activity
WGL_RS01705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WGL_RS01715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WGL_RS01720	COG0101	tRNA pseudouridine synthase activity
WGL_RS01725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WGL_RS01730	COG0285	dihydrofolate synthase activity
WGL_RS01740	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WGL_RS01765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WGL_RS01770	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WGL_RS01775	COG0302	gtp cyclohydrolase
WGL_RS01780	COG0351	phosphomethylpyrimidine kinase
WGL_RS01785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WGL_RS01790	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WGL_RS01795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WGL_RS01800	COG0508	dehydrogenase complex catalyzes the overall conversion of
WGL_RS01805	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WGL_RS01810	COG0157	Belongs to the NadC ModD family
WGL_RS01820	COG3117	lipopolysaccharide transmembrane transporter activity
WGL_RS01830	COG1137	ATPase activity
WGL_RS01840	COG5007	Belongs to the BolA IbaG family
WGL_RS01845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WGL_RS01850	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WGL_RS01855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WGL_RS01860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WGL_RS01870	COG0307	riboflavin synthase, alpha
WGL_RS01875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WGL_RS01880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WGL_RS01885	COG1846	Transcriptional regulator
WGL_RS01890	COG0259	pyridoxamine-phosphate oxidase activity
WGL_RS01895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WGL_RS01900	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WGL_RS01910	COG0114	fumarate hydratase activity
WGL_RS01920	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WGL_RS01930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WGL_RS01935	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WGL_RS01945	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WGL_RS01950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WGL_RS01955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WGL_RS01960	COG0193	aminoacyl-tRNA hydrolase activity
WGL_RS01965	COG0012	GTP binding
WGL_RS01970	COG1376	ErfK ybiS ycfS ynhG family protein
WGL_RS01975	COG0148	phosphopyruvate hydratase activity
WGL_RS01980	COG0504	CTP synthase activity
WGL_RS01990	COG2166	iron-sulfur cluster assembly
WGL_RS01995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WGL_RS02000	COG0719	Fe-S assembly protein
WGL_RS02005	COG0396	ATPase activity
WGL_RS02010	COG0719	Fe-S assembly protein
WGL_RS02015	COG0316	Belongs to the HesB IscA family
WGL_RS02020	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WGL_RS02025	COG0284	orotidine-5'-phosphate decarboxylase activity
WGL_RS02030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WGL_RS02040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WGL_RS02045	COG2916	Histone family protein nucleoid-structuring protein H-NS
WGL_RS02055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WGL_RS02060	COG0788	formyltetrahydrofolate deformylase activity
WGL_RS02075	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WGL_RS02080	COG2894	cell division
WGL_RS02085	COG0850	regulation of cytokinetic process
WGL_RS02090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WGL_RS02095	COG3263	regulation of cellular component size
WGL_RS02100	COG0825	malonyl-CoA metabolic process
WGL_RS02110	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WGL_RS02115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WGL_RS02120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WGL_RS02125	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WGL_RS02130	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
WGL_RS02135	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WGL_RS02140	COG0750	zinc metalloprotease
WGL_RS02150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WGL_RS02155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WGL_RS02160	COG0233	cytoplasmic translational termination
WGL_RS02170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WGL_RS02175	COG0052	Belongs to the universal ribosomal protein uS2 family
WGL_RS02180	COG0024	Methionine aminopeptidase
WGL_RS02185	COG2171	N-acyltransferase activity
WGL_RS02215	COG0037	tRNA processing
WGL_RS02220	COG0037	tRNA processing
WGL_RS02225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WGL_RS02230	COG0756	dUTP diphosphatase activity
WGL_RS02235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WGL_RS02240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WGL_RS02245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WGL_RS02250	COG1758	RNA polymerase activity
WGL_RS02255	COG0194	GDP metabolic process
WGL_RS02260	COG1846	Transcriptional regulator
WGL_RS02265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WGL_RS02270	COG2890	protein-(glutamine-N5) methyltransferase activity
WGL_RS02285	COG2885	chlorophyll binding
WGL_RS02290	COG0823	Involved in the tonB-independent uptake of proteins
WGL_RS02300	COG0848	biopolymer transport protein
WGL_RS02305	COG0811	peptide transport
WGL_RS02310	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WGL_RS02315	COG0045	succinate-CoA ligase (ADP-forming) activity
WGL_RS02320	COG0508	dehydrogenase complex catalyzes the overall conversion of
WGL_RS02325	COG0567	Dehydrogenase, E1 component
WGL_RS02335	COG1053	succinate dehydrogenase
WGL_RS02340	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WGL_RS02350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WGL_RS02355	COG0033	Phosphoglucomutase
WGL_RS02360	COG0716	FMN binding
WGL_RS02370	COG3264	Mechanosensitive ion channel
WGL_RS02370	COG1511	domain protein
WGL_RS02375	COG0688	phosphatidylethanolamine metabolic process
WGL_RS02380	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WGL_RS02385	COG0586	Pfam SNARE associated Golgi protein
WGL_RS02390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WGL_RS02395	COG0006	proline dipeptidase activity
WGL_RS02400	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
WGL_RS02405	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WGL_RS02405	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WGL_RS02405	COG0506	proline dehydrogenase activity
WGL_RS02410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WGL_RS02425	COG0354	folic acid binding
WGL_RS02430	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
WGL_RS02435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WGL_RS02445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WGL_RS02450	COG2095	MarC family integral membrane protein
WGL_RS02455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WGL_RS02460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WGL_RS02470	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WGL_RS02475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WGL_RS02480	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WGL_RS02485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WGL_RS02490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WGL_RS02495	COG2823	Periplasmic or secreted lipoprotein
WGL_RS02500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WGL_RS02505	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WGL_RS02515	COG2226	methyltransferase
WGL_RS02520	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WGL_RS02525	COG0795	lipopolysaccharide-transporting ATPase activity
WGL_RS02530	COG0795	lipopolysaccharide-transporting ATPase activity
WGL_RS02535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WGL_RS02540	COG0525	valine-tRNA ligase activity
WGL_RS02545	COG0540	Belongs to the ATCase OTCase family
WGL_RS02550	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WGL_RS02550	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WGL_RS02555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WGL_RS02565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WGL_RS02570	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WGL_RS02590	COG0358	DNA primase activity
WGL_RS02595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WGL_RS02600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WGL_RS02605	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WGL_RS02610	COG1968	undecaprenyl-diphosphatase activity
WGL_RS02615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WGL_RS02620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WGL_RS02625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WGL_RS02630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WGL_RS02635	COG0142	geranyltranstransferase activity
WGL_RS02640	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WGL_RS02645	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WGL_RS02650	COG2911	Protein conserved in bacteria
WGL_RS02660	COG0729	surface antigen
WGL_RS02665	COG0539	negative regulation of cytoplasmic translation
WGL_RS02670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WGL_RS02675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WGL_RS02680	COG0450	alkyl hydroperoxide reductase
WGL_RS02690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WGL_RS02695	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WGL_RS02705	COG0492	ferredoxin-NADP+ reductase activity
WGL_RS02710	COG0814	amino acid
WGL_RS02720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WGL_RS02725	COG0242	peptide deformylase activity
WGL_RS02730	COG0009	L-threonylcarbamoyladenylate synthase
WGL_RS02745	COG0629	single-stranded DNA binding
WGL_RS02750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WGL_RS02755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WGL_RS02760	COG3785	DNA binding
WGL_RS02770	COG2022	thiamine diphosphate biosynthetic process
WGL_RS02780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WGL_RS02790	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WGL_RS02795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WGL_RS02805	COG0151	Belongs to the GarS family
WGL_RS02810	COG0138	bifunctional purine biosynthesis protein purh
WGL_RS02815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WGL_RS02820	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WGL_RS02820	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WGL_RS02825	COG1072	(Pantothenic acid kinase))
WGL_RS02850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WGL_RS02855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WGL_RS02860	COG0250	Participates in transcription elongation, termination and antitermination
WGL_RS02865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WGL_RS02870	COG0081	regulation of translation
WGL_RS02875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WGL_RS02880	COG0222	ribosome binding
WGL_RS02885	COG0085	RNA polymerase activity
WGL_RS02890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WGL_RS02900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WGL_RS02905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WGL_RS02910	COG0326	Molecular chaperone. Has ATPase activity
WGL_RS02915	COG0563	adenylate kinase activity
WGL_RS02920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WGL_RS02930	COG0670	Belongs to the BI1 family
WGL_RS02935	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WGL_RS02940	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WGL_RS02950	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WGL_RS02955	COG0564	pseudouridine synthase activity
WGL_RS02965	COG0542	response to heat
WGL_RS02970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WGL_RS02975	COG0717	Belongs to the dCTP deaminase family
WGL_RS02980	COG0745	RESPONSE REGULATOR receiver
WGL_RS02985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WGL_RS02990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WGL_RS02995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WGL_RS03000	COG0051	transcription antitermination factor activity, RNA binding
WGL_RS03005	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WGL_RS03010	COG0088	Forms part of the polypeptide exit tunnel
WGL_RS03015	COG0089	rRNA binding
WGL_RS03020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WGL_RS03025	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WGL_RS03030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WGL_RS03035	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WGL_RS03040	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WGL_RS03045	COG0255	Belongs to the universal ribosomal protein uL29 family
WGL_RS03050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WGL_RS03055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WGL_RS03060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WGL_RS03065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WGL_RS03070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WGL_RS03075	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WGL_RS03080	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WGL_RS03085	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WGL_RS03090	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WGL_RS03095	COG1841	ribosomal large subunit assembly
WGL_RS03100	COG0200	Binds to the 23S rRNA
WGL_RS03105	COG0201	protein transport
WGL_RS03110	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WGL_RS03115	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WGL_RS03120	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WGL_RS03125	COG0202	RNA polymerase activity
WGL_RS03130	COG0203	ribosomal protein L17
WGL_RS03135	COG0105	UTP biosynthetic process
WGL_RS03140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WGL_RS03145	COG1426	Protein conserved in bacteria
WGL_RS03150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WGL_RS03155	COG0124	histidyl-tRNA synthetase
WGL_RS03170	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
WGL_RS03175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WGL_RS03185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WGL_RS03190	COG0180	Tryptophanyl-tRNA synthetase
WGL_RS03195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WGL_RS03200	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WGL_RS03205	COG0408	coproporphyrinogen oxidase activity
WGL_RS03210	COG0596	Alpha beta hydrolase
WGL_RS03235	COG0367	asparagine synthase
WGL_RS03240	COG1988	membrane-bound metal-dependent
WGL_RS03245	COG0174	glutamine synthetase
WGL_RS03250	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
WGL_RS03255	COG0460	homoserine dehydrogenase
WGL_RS03255	COG0527	aspartate kinase activity
WGL_RS03265	COG0752	glycyl-tRNA synthetase alpha subunit
WGL_RS03270	COG0751	glycine-tRNA ligase activity
WGL_RS03275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WGL_RS03280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WGL_RS03295	COG0442	prolyl-tRNA aminoacylation
WGL_RS03300	COG0166	Belongs to the GPI family
WGL_RS03305	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
WGL_RS03310	COG1792	Involved in formation and maintenance of cell shape
WGL_RS03315	COG1077	Cell shape determining protein MreB Mrl
WGL_RS03320	COG0511	ligase activity, forming carbon-carbon bonds
WGL_RS03325	COG0439	Biotin carboxylase
WGL_RS03350	COG0579	oxidoreductase
WGL_RS03355	COG0516	GMP reductase activity
WGL_RS03355	COG0517	IMP dehydrogenase activity
WGL_RS03360	COG0519	Catalyzes the synthesis of GMP from XMP
WGL_RS03365	COG1561	YicC-like family, N-terminal region
WGL_RS03370	COG3158	transport of potassium into the cell
WGL_RS03380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WGL_RS03385	COG1780	Probably involved in ribonucleotide reductase function
WGL_RS03395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WGL_RS03400	COG3105	Protein conserved in bacteria
WGL_RS03405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WGL_RS03410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WGL_RS03425	COG1388	LysM domain
WGL_RS03425	COG4942	peptidase
WGL_RS03435	COG0575	Belongs to the CDS family
WGL_RS03440	COG2976	Protein conserved in bacteria