locus-tag	class	description
ESOMN_RS00030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ESOMN_RS00060	COG1349	DNA-binding transcription factor activity
ESOMN_RS00130	COG0813	purine-nucleoside phosphorylase activity
ESOMN_RS00470	COG0516	GMP reductase activity
ESOMN_RS00470	COG0517	IMP dehydrogenase activity
ESOMN_RS00640	COG0051	transcription antitermination factor activity, RNA binding
ESOMN_RS00655	COG0089	rRNA binding
ESOMN_RS00670	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ESOMN_RS00690	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ESOMN_RS00695	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ESOMN_RS00700	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ESOMN_RS00705	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ESOMN_RS00720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ESOMN_RS00725	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ESOMN_RS00730	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ESOMN_RS00745	COG1349	DNA-binding transcription factor activity
ESOMN_RS00750	COG1105	Belongs to the carbohydrate kinase PfkB family
ESOMN_RS00760	COG0563	adenylate kinase activity
ESOMN_RS00785	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ESOMN_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ESOMN_RS00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ESOMN_RS00815	COG1122	ATPase activity
ESOMN_RS00820	COG1122	ATPase activity
ESOMN_RS00850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ESOMN_RS01185	COG1692	metallophosphoesterase
ESOMN_RS01265	COG0537	adenosine 5'-monophosphoramidase activity
ESOMN_RS01310	COG1185	polyribonucleotide nucleotidyltransferase activity
ESOMN_RS01395	COG1799	cell septum assembly
ESOMN_RS01590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ESOMN_RS01590	COG2213	PTS system mannitol-specific
ESOMN_RS01615	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ESOMN_RS01625	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ESOMN_RS01630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ESOMN_RS01645	COG4221	oxidoreductase activity
ESOMN_RS01680	COG0251	oxidation-reduction process
ESOMN_RS01890	COG4224	UPF0291 protein
ESOMN_RS01900	COG3763	UPF0154 protein
ESOMN_RS02065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ESOMN_RS02080	COG0513	Belongs to the DEAD box helicase family
ESOMN_RS02120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ESOMN_RS02190	COG0484	heat shock protein binding
ESOMN_RS02200	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ESOMN_RS02290	COG0335	large ribosomal subunit rRNA binding
ESOMN_RS02325	COG1418	mRNA catabolic process
ESOMN_RS02335	COG1058	Belongs to the CinA family
ESOMN_RS02335	COG1546	Belongs to the CinA family
ESOMN_RS02345	COG3599	regulation of cell shape
ESOMN_RS02360	COG0776	regulation of translation
ESOMN_RS02415	COG0217	transcriptional regulatory protein
ESOMN_RS02425	COG1187	pseudouridine synthase activity
ESOMN_RS02520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ESOMN_RS02545	COG2868	ribosomal protein
ESOMN_RS02635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ESOMN_RS02640	COG0640	Transcriptional regulator
ESOMN_RS02680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ESOMN_RS02735	COG1447	Phosphotransferase system cellobiose-specific component IIA
ESOMN_RS02785	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ESOMN_RS03140	COG1131	(ABC) transporter
ESOMN_RS03190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ESOMN_RS03220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ESOMN_RS03305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ESOMN_RS03360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ESOMN_RS03380	COG1481	regulation of sporulation
ESOMN_RS03400	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ESOMN_RS03425	COG0653	protein targeting
ESOMN_RS03450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ESOMN_RS03455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ESOMN_RS03475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ESOMN_RS03480	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ESOMN_RS03500	COG1122	ATPase activity
ESOMN_RS03565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ESOMN_RS03585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ESOMN_RS03600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ESOMN_RS03645	COG0359	binds to the 23S rRNA
ESOMN_RS03650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ESOMN_RS03730	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ESOMN_RS03745	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ESOMN_RS03750	COG0470	DNA polymerase III
ESOMN_RS03760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ESOMN_RS03790	COG0594	ribonuclease P activity