locus-tag	class	description
H8R18_RS00010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8R18_RS00015	COG0360	Binds together with S18 to 16S ribosomal RNA
H8R18_RS00025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8R18_RS00030	COG0359	binds to the 23S rRNA
H8R18_RS00035	COG0534	Mate efflux family protein
H8R18_RS00040	COG0305	Participates in initiation and elongation during chromosome replication
H8R18_RS00045	COG0351	phosphomethylpyrimidine kinase
H8R18_RS00055	COG0477	Major facilitator Superfamily
H8R18_RS00080	COG0674	pyruvate-flavodoxin oxidoreductase activity
H8R18_RS00090	COG0493	'glutamate synthase
H8R18_RS00095	COG2247	cell wall binding repeat
H8R18_RS00095	COG2385	sporulation resulting in formation of a cellular spore
H8R18_RS00100	COG1086	Polysaccharide biosynthesis protein
H8R18_RS00115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8R18_RS00125	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H8R18_RS00130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8R18_RS00135	COG2390	Transcriptional regulator
H8R18_RS00150	COG0477	Major facilitator Superfamily
H8R18_RS00155	COG1473	amidohydrolase
H8R18_RS00160	COG0561	phosphatase activity
H8R18_RS00165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8R18_RS00165	COG1754	DNA topoisomerase type I activity
H8R18_RS00170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8R18_RS00175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H8R18_RS00190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8R18_RS00195	COG0187	DNA topoisomerase II activity
H8R18_RS00200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8R18_RS00220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8R18_RS00225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8R18_RS00230	COG1012	belongs to the aldehyde dehydrogenase family
H8R18_RS00250	COG1121	(ABC) transporter
H8R18_RS00255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8R18_RS00270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H8R18_RS00310	COG2271	Major facilitator Superfamily
H8R18_RS00315	COG0730	response to heat
H8R18_RS00330	COG3118	belongs to the thioredoxin family
H8R18_RS00340	COG1263	PTS System
H8R18_RS00345	COG2188	Transcriptional regulator
H8R18_RS00365	COG1028	Short-chain dehydrogenase reductase Sdr
H8R18_RS00370	COG1012	belongs to the aldehyde dehydrogenase family
H8R18_RS00400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8R18_RS00410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8R18_RS00410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8R18_RS00410	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H8R18_RS00415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8R18_RS00420	COG3842	ATPase activity
H8R18_RS00430	COG2814	Major facilitator Superfamily
H8R18_RS00435	COG2197	response regulator
H8R18_RS00440	COG4585	Histidine kinase
H8R18_RS00450	COG1131	(ABC) transporter
H8R18_RS00470	COG1070	Carbohydrate kinase
H8R18_RS00475	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H8R18_RS00510	COG0673	inositol 2-dehydrogenase activity
H8R18_RS00515	COG1940	carbohydrate kinase activity
H8R18_RS00515	COG1846	Transcriptional regulator
H8R18_RS00530	COG1940	carbohydrate kinase activity
H8R18_RS00535	COG2211	Major facilitator Superfamily
H8R18_RS00540	COG1472	Belongs to the glycosyl hydrolase 3 family
H8R18_RS00550	COG3507	Belongs to the glycosyl hydrolase 43 family
H8R18_RS00565	COG0673	inositol 2-dehydrogenase activity
H8R18_RS00590	COG0477	Major facilitator Superfamily
H8R18_RS00655	COG1196	nuclear chromosome segregation
H8R18_RS00655	COG0741	lytic transglycosylase activity
H8R18_RS00655	COG0739	heme binding
H8R18_RS00660	COG1388	LysM domain
H8R18_RS00660	COG3103	Sh3 type 3 domain protein
H8R18_RS00660	COG0791	NLP P60 protein
H8R18_RS00680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H8R18_RS00830	COG3250	beta-galactosidase activity
H8R18_RS00835	COG1309	transcriptional regulator
H8R18_RS00860	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H8R18_RS00870	COG0515	serine threonine protein kinase
H8R18_RS00870	COG2815	serine threonine protein kinase
H8R18_RS00875	COG0515	serine threonine protein kinase
H8R18_RS00895	COG1716	ATPase activity
H8R18_RS00900	COG1716	ATPase activity
H8R18_RS00910	COG1266	CAAX protease self-immunity
H8R18_RS00915	COG1854	S-ribosylhomocysteine lyase activity
H8R18_RS00925	COG1780	Probably involved in ribonucleotide reductase function
H8R18_RS00930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8R18_RS00970	COG0277	FAD linked oxidase domain protein
H8R18_RS00970	COG0247	lactate metabolic process
H8R18_RS00990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H8R18_RS00995	COG2873	o-acetylhomoserine
H8R18_RS01015	COG0318	PFAM AMP-dependent synthetase and ligase
H8R18_RS01020	COG0569	domain protein
H8R18_RS01025	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H8R18_RS01080	COG0519	Catalyzes the synthesis of GMP from XMP
H8R18_RS01080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8R18_RS01090	COG2160	L-arabinose isomerase activity
H8R18_RS01095	COG2814	Major facilitator Superfamily
H8R18_RS01105	COG1609	Transcriptional regulator
H8R18_RS01110	COG2855	membrane
H8R18_RS01115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8R18_RS01390	COG4974	Belongs to the 'phage' integrase family
H8R18_RS01410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8R18_RS01420	COG1674	ftsk spoiiie
H8R18_RS01425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8R18_RS01430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8R18_RS01435	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8R18_RS01440	COG0154	amidase activity
H8R18_RS01445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8R18_RS01480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8R18_RS01485	COG1333	cytochrome c biogenesis protein
H8R18_RS01490	COG0785	Cytochrome C biogenesis protein
H8R18_RS01500	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H8R18_RS01520	COG0166	Belongs to the GPI family
H8R18_RS01530	COG0676	glucose-6-phosphate 1-epimerase activity
H8R18_RS01535	COG0039	L-malate dehydrogenase activity
H8R18_RS01550	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8R18_RS01555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H8R18_RS01575	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H8R18_RS01605	COG2151	metal-sulfur cluster biosynthetic enzyme
H8R18_RS01605	COG0489	protein tyrosine kinase activity
H8R18_RS01615	COG2239	Acts as a magnesium transporter
H8R18_RS01635	COG3883	PFAM NLP P60 protein
H8R18_RS01635	COG0791	NLP P60 protein
H8R18_RS01645	COG0438	transferase activity, transferring glycosyl groups
H8R18_RS01675	COG0438	transferase activity, transferring glycosyl groups
H8R18_RS01735	COG0424	maF-like protein
H8R18_RS01745	COG0745	RESPONSE REGULATOR receiver
H8R18_RS01750	COG5002	protein histidine kinase activity
H8R18_RS01770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8R18_RS01775	COG1316	TRANSCRIPTIONal
H8R18_RS01780	COG1316	TRANSCRIPTIONal
H8R18_RS01835	COG1215	transferase activity, transferring glycosyl groups
H8R18_RS01840	COG1482	cell wall glycoprotein biosynthetic process
H8R18_RS01860	COG4981	capsule polysaccharide biosynthetic process
H8R18_RS01880	COG0745	RESPONSE REGULATOR receiver
H8R18_RS01885	COG5000	phosphorelay sensor kinase activity
H8R18_RS01885	COG5002	protein histidine kinase activity
H8R18_RS01900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H8R18_RS01945	COG0419	ATPase involved in DNA repair
H8R18_RS01950	COG0420	3'-5' exonuclease activity
H8R18_RS01960	COG0710	3-dehydroquinate dehydratase activity
H8R18_RS01970	COG1595	DNA-templated transcription, initiation
H8R18_RS01980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8R18_RS01985	COG1162	GTPase activity
H8R18_RS01990	COG0483	inositol monophosphate 1-phosphatase activity
H8R18_RS01995	COG0567	Dehydrogenase, E1 component
H8R18_RS01995	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8R18_RS02010	COG0741	lytic transglycosylase activity
H8R18_RS02010	COG1196	nuclear chromosome segregation
H8R18_RS02010	COG0739	heme binding
H8R18_RS02020	COG0584	glycerophosphoryl diester phosphodiesterase
H8R18_RS02040	COG0018	arginyl-trna synthetase
H8R18_RS02050	COG0460	homoserine dehydrogenase
H8R18_RS02055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8R18_RS02060	COG0083	homoserine kinase activity
H8R18_RS02070	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H8R18_RS02080	COG0459	protein refolding
H8R18_RS02095	COG2205	protein histidine kinase activity
H8R18_RS02100	COG0745	RESPONSE REGULATOR receiver
H8R18_RS02125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8R18_RS02130	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8R18_RS02150	COG4605	iron ion homeostasis
H8R18_RS02175	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8R18_RS02180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8R18_RS02200	COG1278	Cold shock
H8R18_RS02210	COG2252	PERMEase
H8R18_RS02215	COG0436	Aminotransferase
H8R18_RS02220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8R18_RS02225	COG0045	succinate-CoA ligase (ADP-forming) activity
H8R18_RS02250	COG2197	response regulator
H8R18_RS02280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H8R18_RS02290	COG0519	Catalyzes the synthesis of GMP from XMP
H8R18_RS02290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8R18_RS02295	COG0084	hydrolase, TatD family'
H8R18_RS02315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8R18_RS02320	COG0488	(ABC) transporter
H8R18_RS02325	COG0577	efflux transmembrane transporter activity
H8R18_RS02330	COG0577	efflux transmembrane transporter activity
H8R18_RS02330	COG1136	(ABC) transporter
H8R18_RS02345	COG1309	transcriptional regulator
H8R18_RS02360	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H8R18_RS02365	COG0193	aminoacyl-tRNA hydrolase activity
H8R18_RS02415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8R18_RS02430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8R18_RS02440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8R18_RS02445	COG1722	exodeoxyribonuclease VII activity
H8R18_RS02450	COG1570	exodeoxyribonuclease VII activity
H8R18_RS02485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8R18_RS02495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8R18_RS02500	COG0802	atpase or kinase
H8R18_RS02510	COG0456	acetyltransferase
H8R18_RS02535	COG1321	iron dependent repressor
H8R18_RS02545	COG0589	response to stress
H8R18_RS02560	COG0254	rRNA binding
H8R18_RS02565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8R18_RS02580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8R18_RS02590	COG0356	it plays a direct role in the translocation of protons across the membrane
H8R18_RS02595	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8R18_RS02600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8R18_RS02605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8R18_RS02610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8R18_RS02620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8R18_RS02625	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8R18_RS02635	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
H8R18_RS02645	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8R18_RS02660	COG0778	Nitroreductase
H8R18_RS02710	COG2271	Major facilitator Superfamily
H8R18_RS02725	COG0366	Alpha amylase catalytic
H8R18_RS02745	COG0180	Tryptophanyl-tRNA synthetase
H8R18_RS02755	COG2086	electron transfer activity
H8R18_RS02760	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H8R18_RS02765	COG1104	cysteine desulfurase activity
H8R18_RS02775	COG0482	sulfurtransferase activity
H8R18_RS02800	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8R18_RS02810	COG1438	arginine binding
H8R18_RS02835	COG0612	Peptidase, M16
H8R18_RS02840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8R18_RS02855	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H8R18_RS02865	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8R18_RS02865	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H8R18_RS02870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8R18_RS02885	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8R18_RS02885	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H8R18_RS02895	COG1674	ftsk spoiiie
H8R18_RS02915	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8R18_RS02920	COG2137	regulation of response to DNA damage stimulus
H8R18_RS02925	COG1546	Belongs to the CinA family
H8R18_RS02925	COG1058	Belongs to the CinA family
H8R18_RS02935	COG2409	Drug exporters of the RND superfamily
H8R18_RS02940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8R18_RS02945	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8R18_RS02950	COG2890	protein-(glutamine-N5) methyltransferase activity
H8R18_RS02955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8R18_RS02980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8R18_RS02990	COG3973	AAA domain
H8R18_RS03000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8R18_RS03010	COG2001	Belongs to the MraZ family
H8R18_RS03015	COG0275	rRNA processing
H8R18_RS03025	COG0768	penicillin binding
H8R18_RS03040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8R18_RS03045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8R18_RS03060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8R18_RS03080	COG1799	cell septum assembly
H8R18_RS03095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8R18_RS03105	COG0587	DNA-directed DNA polymerase activity
H8R18_RS03115	COG2501	S4 domain
H8R18_RS03120	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8R18_RS03135	COG0131	Imidazoleglycerol-phosphate dehydratase
H8R18_RS03145	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8R18_RS03160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H8R18_RS03170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H8R18_RS03175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8R18_RS03185	COG1027	Aspartate ammonia-lyase
H8R18_RS03190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H8R18_RS03205	COG0742	ribosomal rna small subunit methyltransferase
H8R18_RS03210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8R18_RS03230	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8R18_RS03245	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H8R18_RS03250	COG4988	ABC transporter
H8R18_RS03255	COG1294	oxidase, subunit
H8R18_RS03260	COG1271	oxidase subunit
H8R18_RS03265	COG1530	ribonuclease E activity
H8R18_RS03270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8R18_RS03275	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8R18_RS03280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8R18_RS03285	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8R18_RS03290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8R18_RS03295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8R18_RS03305	COG0799	negative regulation of ribosome biogenesis
H8R18_RS03310	COG0406	alpha-ribazole phosphatase activity
H8R18_RS03340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H8R18_RS03355	COG3842	ATPase activity
H8R18_RS03365	COG0513	Belongs to the DEAD box helicase family
H8R18_RS03385	COG0210	DNA helicase
H8R18_RS03430	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H8R18_RS03435	COG2884	Cell division ATP-binding protein ftsE
H8R18_RS03450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H8R18_RS03460	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
H8R18_RS03465	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H8R18_RS03470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H8R18_RS03485	COG1175	transmembrane transport
H8R18_RS03490	COG0395	ABC-type sugar transport system, permease component
H8R18_RS03535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8R18_RS03570	COG0438	transferase activity, transferring glycosyl groups
H8R18_RS03585	COG0719	Fe-S assembly protein
H8R18_RS03600	COG0396	ATPase activity
H8R18_RS03610	COG0822	iron-sulfur transferase activity
H8R18_RS03615	COG2151	metal-sulfur cluster biosynthetic enzyme
H8R18_RS03630	COG2188	Transcriptional regulator
H8R18_RS03635	COG0488	(ABC) transporter
H8R18_RS03650	COG1136	(ABC) transporter
H8R18_RS03650	COG0577	efflux transmembrane transporter activity
H8R18_RS03665	COG0297	glycogen (starch) synthase activity
H8R18_RS03670	COG1119	ATPase activity
H8R18_RS03675	COG0174	glutamine synthetase
H8R18_RS03680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H8R18_RS03695	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8R18_RS03700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8R18_RS03730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8R18_RS03735	COG0587	DNA-directed DNA polymerase activity
H8R18_RS03770	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H8R18_RS03775	COG0667	Aldo Keto reductase
H8R18_RS03780	COG1968	undecaprenyl-diphosphatase activity
H8R18_RS03800	COG1222	aaa ATPase
H8R18_RS03825	COG0107	imidazoleglycerol-phosphate synthase activity
H8R18_RS03840	COG0134	indole-3-glycerol-phosphate synthase activity
H8R18_RS03845	COG0133	tryptophan synthase activity
H8R18_RS03855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8R18_RS03885	COG4221	oxidoreductase activity
H8R18_RS03890	COG0539	negative regulation of cytoplasmic translation
H8R18_RS03895	COG2050	protein possibly involved in aromatic compounds catabolism
H8R18_RS03905	COG0237	dephospho-CoA kinase activity
H8R18_RS03905	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H8R18_RS03910	COG0556	nucleotide-excision repair
H8R18_RS03915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8R18_RS03950	COG0640	Transcriptional regulator
H8R18_RS03960	COG0322	excinuclease ABC activity
H8R18_RS03965	COG1660	Displays ATPase and GTPase activities
H8R18_RS03975	COG1481	regulation of sporulation
H8R18_RS03980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8R18_RS03985	COG0126	phosphoglycerate kinase activity
H8R18_RS03990	COG0149	triose-phosphate isomerase activity
H8R18_RS03995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H8R18_RS04015	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H8R18_RS04020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H8R18_RS04025	COG1187	pseudouridine synthase activity
H8R18_RS04035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8R18_RS04040	COG1160	GTP binding
H8R18_RS04050	COG0477	Major facilitator Superfamily
H8R18_RS04085	COG1263	PTS System
H8R18_RS04085	COG2190	(PTS) system
H8R18_RS04085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8R18_RS04090	COG1263	PTS System
H8R18_RS04090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8R18_RS04090	COG2190	(PTS) system
H8R18_RS04115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8R18_RS04125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8R18_RS04130	COG1560	Kdo2-lipid A biosynthetic process
H8R18_RS04135	COG0438	transferase activity, transferring glycosyl groups
H8R18_RS04155	COG1051	belongs to the nudix hydrolase family
H8R18_RS04160	COG0217	transcriptional regulatory protein
H8R18_RS04170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H8R18_RS04180	COG2255	four-way junction helicase activity
H8R18_RS04190	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8R18_RS04195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8R18_RS04200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8R18_RS04205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8R18_RS04215	COG1196	nuclear chromosome segregation
H8R18_RS04225	COG0124	histidyl-tRNA synthetase
H8R18_RS04235	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8R18_RS04240	COG0009	L-threonylcarbamoyladenylate synthase
H8R18_RS04250	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H8R18_RS04270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8R18_RS04280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8R18_RS04310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8R18_RS04320	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H8R18_RS04325	COG0540	Belongs to the ATCase OTCase family
H8R18_RS04330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8R18_RS04335	COG0505	Belongs to the CarA family
H8R18_RS04345	COG0284	orotidine-5'-phosphate decarboxylase activity
H8R18_RS04355	COG0194	GDP metabolic process
H8R18_RS04360	COG1758	RNA polymerase activity
H8R18_RS04375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8R18_RS04385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H8R18_RS04390	COG0140	phosphoribosyl-ATP diphosphatase activity
H8R18_RS04395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8R18_RS04425	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H8R18_RS04430	COG1216	Glycosyl transferase, family 2
H8R18_RS04440	COG0531	amino acid
H8R18_RS04445	COG2233	PERMEase
H8R18_RS04460	COG1716	ATPase activity
H8R18_RS04495	COG0330	HflC and HflK could
H8R18_RS04545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8R18_RS04555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8R18_RS04560	COG0531	amino acid
H8R18_RS04565	COG0569	domain protein
H8R18_RS04610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8R18_RS04640	COG0142	geranyltranstransferase activity
H8R18_RS04650	COG2815	serine threonine protein kinase
H8R18_RS04650	COG0515	serine threonine protein kinase
H8R18_RS04655	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H8R18_RS04690	COG0545	Peptidyl-prolyl cis-trans isomerase
H8R18_RS04705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8R18_RS04715	COG0167	dihydroorotate dehydrogenase activity
H8R18_RS04745	COG1605	Chorismate mutase
H8R18_RS04745	COG0287	Prephenate dehydrogenase
H8R18_RS04750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8R18_RS04760	COG0740	serine-type endopeptidase activity
H8R18_RS04775	COG4191	Histidine kinase
H8R18_RS04775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8R18_RS04800	COG0346	lactoylglutathione lyase activity
H8R18_RS04805	COG1609	Transcriptional regulator
H8R18_RS04830	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8R18_RS04840	COG1739	Uncharacterized protein family UPF0029
H8R18_RS04850	COG1045	serine acetyltransferase
H8R18_RS04865	COG3590	peptidase
H8R18_RS04875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8R18_RS04885	COG1946	Acyl-CoA thioesterase
H8R18_RS04900	COG4989	oxidoreductase activity
H8R18_RS04915	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H8R18_RS04935	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8R18_RS04945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8R18_RS04950	COG0066	3-isopropylmalate dehydratase activity
H8R18_RS04955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8R18_RS04990	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H8R18_RS04995	COG1115	amino acid carrier protein
H8R18_RS05010	COG1115	amino acid carrier protein
H8R18_RS05015	COG1115	amino acid carrier protein
H8R18_RS05020	COG1115	amino acid carrier protein
H8R18_RS05025	COG1115	amino acid carrier protein
H8R18_RS05035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8R18_RS05045	COG0129	dihydroxy-acid dehydratase activity
H8R18_RS05055	COG1957	nucleoside hydrolase
H8R18_RS05065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8R18_RS05070	COG0473	3-isopropylmalate dehydrogenase activity
H8R18_RS05115	COG3949	Membrane
H8R18_RS05130	COG1136	(ABC) transporter
H8R18_RS05140	COG2197	response regulator
H8R18_RS05155	COG3480	Lon protease (S16) C-terminal proteolytic domain
H8R18_RS05170	COG0210	DNA helicase
H8R18_RS05175	COG2816	NAD+ diphosphatase activity
H8R18_RS05180	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H8R18_RS05185	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8R18_RS05190	COG1234	tRNA 3'-trailer cleavage
H8R18_RS05195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H8R18_RS05205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H8R18_RS05255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8R18_RS05260	COG0165	Argininosuccinate lyase
H8R18_RS05265	COG0137	argininosuccinate synthase activity
H8R18_RS05280	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H8R18_RS05300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8R18_RS05415	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8R18_RS05420	COG0750	zinc metalloprotease
H8R18_RS05425	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8R18_RS05435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8R18_RS05445	COG0233	cytoplasmic translational termination
H8R18_RS05455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8R18_RS05460	COG0052	Belongs to the universal ribosomal protein uS2 family
H8R18_RS05495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8R18_RS05500	COG0681	Belongs to the peptidase S26 family
H8R18_RS05505	COG0335	large ribosomal subunit rRNA binding
H8R18_RS05510	COG0336	Belongs to the RNA methyltransferase TrmD family
H8R18_RS05515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8R18_RS05520	COG0546	phosphoglycolate phosphatase activity
H8R18_RS05525	COG1837	Belongs to the UPF0109 family
H8R18_RS05530	COG0228	four-way junction DNA binding
H8R18_RS05535	COG0483	inositol monophosphate 1-phosphatase activity
H8R18_RS05565	COG0105	UTP biosynthetic process
H8R18_RS05575	COG0328	RNA-DNA hybrid ribonuclease activity
H8R18_RS05580	COG0285	dihydrofolate synthase activity
H8R18_RS05585	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H8R18_RS05595	COG4209	transmembrane transport
H8R18_RS05600	COG0395	ABC-type sugar transport system, permease component
H8R18_RS05615	COG1621	beta-fructofuranosidase activity
H8R18_RS05630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8R18_RS05645	COG0789	Transcriptional regulator
H8R18_RS05660	COG0110	maltose O-acetyltransferase activity
H8R18_RS05665	COG4555	ABC transporter
H8R18_RS05680	COG1162	GTPase activity
H8R18_RS05685	COG2814	Major facilitator Superfamily
H8R18_RS05705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8R18_RS05710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8R18_RS05715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8R18_RS05725	COG0195	Participates in both transcription termination and antitermination
H8R18_RS05730	COG0779	Required for maturation of 30S ribosomal subunits
H8R18_RS05760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8R18_RS05775	COG0006	proline dipeptidase activity
H8R18_RS05795	COG1140	nitrate reductase beta subunit
H8R18_RS05810	COG0746	molybdenum cofactor guanylyltransferase activity
H8R18_RS05825	COG0314	molybdopterin synthase activity
H8R18_RS05840	COG0315	cyclic pyranopterin monophosphate synthase activity
H8R18_RS05890	COG0833	amino acid
H8R18_RS05900	COG1185	polyribonucleotide nucleotidyltransferase activity
H8R18_RS05905	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8R18_RS05910	COG0358	DNA primase activity
H8R18_RS05925	COG1063	alcohol dehydrogenase
H8R18_RS05950	COG0423	glycine-tRNA ligase activity
H8R18_RS05955	COG0803	Belongs to the bacterial solute-binding protein 9 family
H8R18_RS05955	COG3443	Belongs to the bacterial solute-binding protein 9 family
H8R18_RS05960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H8R18_RS05965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8R18_RS05975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8R18_RS05980	COG1381	Involved in DNA repair and RecF pathway recombination
H8R18_RS05985	COG3104	oligopeptide transport
H8R18_RS05990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8R18_RS05995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8R18_RS06005	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8R18_RS06020	COG0484	heat shock protein binding
H8R18_RS06025	COG1420	regulation of RNA biosynthetic process
H8R18_RS06030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8R18_RS06035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8R18_RS06035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8R18_RS06065	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8R18_RS06070	COG0481	GTPase activity
H8R18_RS06075	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H8R18_RS06080	COG0268	Binds directly to 16S ribosomal RNA
H8R18_RS06110	COG0495	leucyl-tRNA aminoacylation
H8R18_RS06115	COG0783	Belongs to the Dps family
H8R18_RS06120	COG0537	adenosine 5'-monophosphoramidase activity
H8R18_RS06160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8R18_RS06170	COG1970	mechanosensitive ion channel activity
H8R18_RS06215	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H8R18_RS06220	COG2224	Isocitrate lyase
H8R18_RS06255	COG1131	(ABC) transporter
H8R18_RS06280	COG0395	ABC-type sugar transport system, permease component
H8R18_RS06290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8R18_RS06325	COG3711	transcriptional antiterminator
H8R18_RS06335	COG1263	PTS System
H8R18_RS06335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8R18_RS06335	COG2190	(PTS) system
H8R18_RS06345	COG0667	Aldo Keto reductase
H8R18_RS06355	COG1116	anion transmembrane transporter activity
H8R18_RS06360	COG0515	serine threonine protein kinase
H8R18_RS06400	COG0114	fumarate hydratase activity
H8R18_RS06435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H8R18_RS06460	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H8R18_RS06475	COG0203	ribosomal protein L17
H8R18_RS06480	COG0202	RNA polymerase activity
H8R18_RS06485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H8R18_RS06495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H8R18_RS06500	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H8R18_RS06525	COG1841	ribosomal large subunit assembly
H8R18_RS06530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H8R18_RS06555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8R18_RS06560	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H8R18_RS06565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H8R18_RS06575	COG1136	(ABC) transporter
H8R18_RS06575	COG0577	efflux transmembrane transporter activity
H8R18_RS06590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8R18_RS06595	COG0255	Belongs to the universal ribosomal protein uL29 family
H8R18_RS06600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8R18_RS06605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H8R18_RS06610	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H8R18_RS06615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H8R18_RS06620	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8R18_RS06625	COG0089	rRNA binding
H8R18_RS06635	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8R18_RS06640	COG0051	transcription antitermination factor activity, RNA binding
H8R18_RS06650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8R18_RS06660	COG0049	tRNA binding
H8R18_RS06675	COG3971	2-oxopent-4-enoate hydratase activity
H8R18_RS06695	COG1012	belongs to the aldehyde dehydrogenase family
H8R18_RS06705	COG1802	Transcriptional regulator
H8R18_RS06710	COG0477	Major facilitator Superfamily
H8R18_RS06720	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8R18_RS06730	COG0477	Major facilitator Superfamily
H8R18_RS06740	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8R18_RS06740	COG2755	lipolytic protein G-D-S-L family
H8R18_RS06750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8R18_RS06760	COG0644	oxidoreductase
H8R18_RS06780	COG1476	TRANSCRIPTIONal
H8R18_RS06810	COG3655	Transcriptional regulator
H8R18_RS06815	COG1132	(ABC) transporter
H8R18_RS06830	COG1132	(ABC) transporter
H8R18_RS06840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8R18_RS06845	COG2985	domain, Protein
H8R18_RS06845	COG0569	domain protein
H8R18_RS06875	COG1302	Protein conserved in bacteria
H8R18_RS06935	COG3842	ATPase activity
H8R18_RS06940	COG1177	transmembrane transport
H8R18_RS06980	COG1006	Multisubunit Na H antiporter MnhC subunit
H8R18_RS06985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8R18_RS06985	COG2111	Na H antiporter
H8R18_RS06995	COG0717	Belongs to the dCTP deaminase family
H8R18_RS07005	COG3477	response to acidic pH
H8R18_RS07010	COG5002	protein histidine kinase activity
H8R18_RS07015	COG5002	protein histidine kinase activity
H8R18_RS07025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8R18_RS07050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8R18_RS07055	COG1597	lipid kinase activity
H8R18_RS07055	COG1803	Methylglyoxal synthase
H8R18_RS07080	COG1643	Atp-dependent helicase
H8R18_RS07105	COG0366	Alpha amylase catalytic
H8R18_RS07125	COG1362	aminopeptidase activity
H8R18_RS07140	COG0081	regulation of translation
H8R18_RS07145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H8R18_RS07170	COG0745	RESPONSE REGULATOR receiver
H8R18_RS07175	COG5002	protein histidine kinase activity
H8R18_RS07175	COG3850	Histidine kinase
H8R18_RS07185	COG0436	Aminotransferase
H8R18_RS07190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8R18_RS07205	COG2814	Major facilitator Superfamily
H8R18_RS07210	COG1349	DNA-binding transcription factor activity
H8R18_RS07215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H8R18_RS07235	COG0584	glycerophosphoryl diester phosphodiesterase
H8R18_RS07240	COG0501	Belongs to the peptidase M48B family
H8R18_RS07250	COG0142	geranyltranstransferase activity
H8R18_RS07265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8R18_RS07270	COG0713	ATP synthesis coupled electron transport
H8R18_RS07275	COG0839	Belongs to the complex I subunit 6 family
H8R18_RS07280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8R18_RS07285	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H8R18_RS07310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H8R18_RS07330	COG2226	methyltransferase
H8R18_RS07335	COG0406	alpha-ribazole phosphatase activity
H8R18_RS07375	COG4948	Mandelate Racemase Muconate Lactonizing
H8R18_RS07380	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H8R18_RS07385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8R18_RS07390	COG1169	isochorismate synthase
H8R18_RS07405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8R18_RS07410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8R18_RS07425	COG1643	Atp-dependent helicase
H8R18_RS07435	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H8R18_RS07445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8R18_RS07455	COG0488	(ABC) transporter
H8R18_RS07460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8R18_RS07470	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
H8R18_RS07475	COG0363	glucosamine-6-phosphate deaminase activity
H8R18_RS07485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8R18_RS07520	COG1113	amino acid transport
H8R18_RS07530	COG1834	amidinotransferase
H8R18_RS07535	COG1842	Phage shock protein A
H8R18_RS07550	COG0519	Catalyzes the synthesis of GMP from XMP
H8R18_RS07560	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8R18_RS07565	COG1309	transcriptional regulator
H8R18_RS07570	COG3848	Pyruvate phosphate dikinase
H8R18_RS07570	COG0574	Belongs to the PEP-utilizing enzyme family
H8R18_RS07575	COG0574	Belongs to the PEP-utilizing enzyme family
H8R18_RS07575	COG3848	Pyruvate phosphate dikinase
H8R18_RS07585	COG0534	Mate efflux family protein
H8R18_RS07600	COG3848	Pyruvate phosphate dikinase
H8R18_RS07600	COG0574	Belongs to the PEP-utilizing enzyme family
H8R18_RS07610	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H8R18_RS07670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8R18_RS07675	COG0440	acetolactate synthase activity
H8R18_RS07685	COG0569	domain protein
H8R18_RS07685	COG2985	domain, Protein
H8R18_RS07690	COG2211	Major facilitator Superfamily
H8R18_RS07715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8R18_RS07765	COG4221	oxidoreductase activity
H8R18_RS07770	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8R18_RS07790	COG0542	response to heat
H8R18_RS07805	COG0789	Transcriptional regulator
H8R18_RS07810	COG0484	heat shock protein binding
H8R18_RS07820	COG0443	Heat shock 70 kDa protein
H8R18_RS07835	COG0028	Belongs to the TPP enzyme family
H8R18_RS07855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8R18_RS07865	COG1490	D-aminoacyl-tRNA deacylase activity
H8R18_RS07870	COG3485	protocatechuate 3,4-dioxygenase
H8R18_RS07935	COG1461	Dihydroxyacetone kinase
H8R18_RS07940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8R18_RS07940	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H8R18_RS07940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8R18_RS07945	COG0406	alpha-ribazole phosphatase activity
H8R18_RS07945	COG0494	nUDIX hydrolase
H8R18_RS07950	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8R18_RS07960	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H8R18_RS07965	COG0519	Catalyzes the synthesis of GMP from XMP
H8R18_RS07965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8R18_RS07970	COG0564	pseudouridine synthase activity
H8R18_RS07990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8R18_RS08000	COG0302	gtp cyclohydrolase
H8R18_RS08015	COG0037	tRNA processing
H8R18_RS08020	COG2027	D-alanyl-D-alanine carboxypeptidase
H8R18_RS08035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H8R18_RS08040	COG2011	ABC-type metal ion transport system permease component
H8R18_RS08055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8R18_RS08080	COG1132	(ABC) transporter
H8R18_RS08100	COG1329	Transcriptional regulator
H8R18_RS08105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8R18_RS08115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8R18_RS08130	COG0343	queuine tRNA-ribosyltransferase activity
H8R18_RS08135	COG0215	cysteine-tRNA ligase activity
H8R18_RS08145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8R18_RS08165	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8R18_RS08175	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8R18_RS08235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8R18_RS08235	COG2755	lipolytic protein G-D-S-L family
H8R18_RS08250	COG2271	Major facilitator Superfamily
H8R18_RS08265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H8R18_RS08270	COG0477	Major facilitator Superfamily
H8R18_RS08300	COG1086	Polysaccharide biosynthesis protein
H8R18_RS08305	COG0047	phosphoribosylformylglycinamidine synthase activity
H8R18_RS08315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8R18_RS08325	COG0151	Belongs to the GarS family
H8R18_RS08330	COG0714	Associated with various cellular activities
H8R18_RS08375	COG0577	efflux transmembrane transporter activity
H8R18_RS08385	COG1136	(ABC) transporter
H8R18_RS08385	COG0577	efflux transmembrane transporter activity
H8R18_RS08405	COG1882	Formate acetyltransferase
H8R18_RS08415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H8R18_RS08430	COG4770	biotin carboxylase activity
H8R18_RS08445	COG0736	holo-[acyl-carrier-protein] synthase activity
H8R18_RS08475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8R18_RS08480	COG1408	metallophosphoesterase
H8R18_RS08490	COG0572	uridine kinase
H8R18_RS08495	COG2326	polyphosphate kinase activity
H8R18_RS08500	COG1335	isochorismatase
H8R18_RS08510	COG2354	Protein conserved in bacteria
H8R18_RS08515	COG1070	Carbohydrate kinase
H8R18_RS08525	COG1940	carbohydrate kinase activity
H8R18_RS08530	COG2135	peptidase activity
H8R18_RS08535	COG0617	tRNA 3'-terminal CCA addition
H8R18_RS08540	COG1051	belongs to the nudix hydrolase family
H8R18_RS08560	COG3118	belongs to the thioredoxin family
H8R18_RS08565	COG3118	belongs to the thioredoxin family
H8R18_RS08570	COG2264	protein methyltransferase activity
H8R18_RS08600	COG4868	Belongs to the UPF0371 family
H8R18_RS08655	COG0596	Alpha beta hydrolase
H8R18_RS08665	COG1131	(ABC) transporter
H8R18_RS08680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8R18_RS08685	COG0592	DNA-directed DNA polymerase activity
H8R18_RS08695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8R18_RS08700	COG3442	glutamine amidotransferase
H8R18_RS08735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8R18_RS08740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8R18_RS08745	COG0492	ferredoxin-NADP+ reductase activity
H8R18_RS08750	COG0181	hydroxymethylbilane synthase activity
H8R18_RS08780	COG1114	Component of the transport system for branched-chain amino acids
H8R18_RS08785	COG1114	Component of the transport system for branched-chain amino acids
H8R18_RS08790	COG0406	alpha-ribazole phosphatase activity
H8R18_RS08800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8R18_RS08815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H8R18_RS08825	COG1668	transmembrane transport
H8R18_RS08885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8R18_RS08890	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8R18_RS08905	COG1192	Involved in chromosome partitioning
H8R18_RS08910	COG0357	Ribosomal RNA small subunit methyltransferase G
H8R18_RS08930	COG0706	membrane insertase activity
H8R18_RS08935	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8R18_RS08940	COG0594	ribonuclease P activity
H8R18_RS08945	COG0230	Belongs to the bacterial ribosomal protein bL34 family