locus-tag	class	description
HM989_RS00015	COG2885	chlorophyll binding
HM989_RS00015	COG3047	cAMP biosynthetic process
HM989_RS00020	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HM989_RS00030	COG1482	cell wall glycoprotein biosynthetic process
HM989_RS00065	COG1073	alpha beta
HM989_RS00095	COG1595	DNA-templated transcription, initiation
HM989_RS00110	COG0513	Belongs to the DEAD box helicase family
HM989_RS00115	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HM989_RS00130	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HM989_RS00135	COG2258	MOSC domain
HM989_RS00150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM989_RS00160	COG4771	TonB-dependent receptor
HM989_RS00165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM989_RS00170	COG0326	Molecular chaperone. Has ATPase activity
HM989_RS00180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM989_RS00210	COG0110	maltose O-acetyltransferase activity
HM989_RS00215	COG1064	alcohol dehydrogenase
HM989_RS00245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM989_RS00255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HM989_RS00265	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM989_RS00270	COG1902	pentaerythritol trinitrate reductase activity
HM989_RS00275	COG0450	alkyl hydroperoxide reductase
HM989_RS00295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HM989_RS00305	COG0179	Fumarylacetoacetate (FAA) hydrolase
HM989_RS00315	COG1058	Belongs to the CinA family
HM989_RS00315	COG1546	Belongs to the CinA family
HM989_RS00320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HM989_RS00325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HM989_RS00335	COG0552	protein localization to endoplasmic reticulum
HM989_RS00340	COG0154	amidase activity
HM989_RS00350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM989_RS00365	COG0656	L-ascorbic acid biosynthetic process
HM989_RS00375	COG4206	TonB-dependent receptor
HM989_RS00415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HM989_RS00430	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HM989_RS00470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HM989_RS00470	COG0519	Catalyzes the synthesis of GMP from XMP
HM989_RS00490	COG0504	CTP synthase activity
HM989_RS00495	COG0706	membrane insertase activity
HM989_RS00500	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM989_RS00505	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM989_RS00515	COG0482	sulfurtransferase activity
HM989_RS00565	COG0534	Mate efflux family protein
HM989_RS00580	COG0671	phosphoesterase, PA-phosphatase related
HM989_RS00585	COG0671	phosphoesterase, PA-phosphatase related
HM989_RS00595	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM989_RS00595	COG3952	Lipid A Biosynthesis
HM989_RS00600	COG0463	Glycosyl transferase, family 2
HM989_RS00615	COG1595	DNA-templated transcription, initiation
HM989_RS00630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM989_RS00650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HM989_RS00685	COG2827	Endonuclease containing a URI domain
HM989_RS00690	COG0653	protein targeting
HM989_RS00705	COG1136	(ABC) transporter
HM989_RS00715	COG0488	(ABC) transporter
HM989_RS00725	COG3206	protein involved in exopolysaccharide biosynthesis
HM989_RS00725	COG0489	protein tyrosine kinase activity
HM989_RS00730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM989_RS00735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HM989_RS00760	COG0438	transferase activity, transferring glycosyl groups
HM989_RS00765	COG0463	Glycosyl transferase, family 2
HM989_RS00770	COG0463	Glycosyl transferase, family 2
HM989_RS00770	COG1216	Glycosyl transferase, family 2
HM989_RS00780	COG1216	Glycosyl transferase, family 2
HM989_RS00805	COG0438	transferase activity, transferring glycosyl groups
HM989_RS00850	COG0463	Glycosyl transferase, family 2
HM989_RS00880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM989_RS00900	COG2354	Protein conserved in bacteria
HM989_RS00910	COG1137	ATPase activity
HM989_RS00915	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HM989_RS00920	COG0805	protein transport
HM989_RS00925	COG0517	IMP dehydrogenase activity
HM989_RS00925	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HM989_RS00930	COG0514	ATP-dependent DNA helicase (RecQ)
HM989_RS00945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM989_RS01000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HM989_RS01010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HM989_RS01020	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HM989_RS01050	COG0681	Belongs to the peptidase S26 family
HM989_RS01055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HM989_RS01065	COG1475	DNA binding
HM989_RS01070	COG1192	Involved in chromosome partitioning
HM989_RS01075	COG0612	Peptidase, M16
HM989_RS01080	COG1028	Short-chain dehydrogenase reductase Sdr
HM989_RS01085	COG4946	Tricorn protease homolog
HM989_RS01085	COG1506	peptidase
HM989_RS01085	COG0823	Involved in the tonB-independent uptake of proteins
HM989_RS01090	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM989_RS01090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM989_RS01100	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM989_RS01110	COG0572	uridine kinase
HM989_RS01115	COG2010	Cytochrome c
HM989_RS01120	COG2133	pyrroloquinoline quinone binding
HM989_RS01135	COG1012	belongs to the aldehyde dehydrogenase family
HM989_RS01180	COG1917	Cupin 2, conserved barrel domain protein
HM989_RS01180	COG2207	Transcriptional regulator
HM989_RS01250	COG0783	Belongs to the Dps family
HM989_RS01265	COG0714	Associated with various cellular activities
HM989_RS01335	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HM989_RS01355	COG3547	Transposase (IS116 IS110 IS902 family)
HM989_RS01385	COG3547	Transposase (IS116 IS110 IS902 family)
HM989_RS01420	COG3275	phosphorelay sensor kinase activity
HM989_RS01440	COG3279	Response regulator of the LytR AlgR family
HM989_RS01475	COG1595	DNA-templated transcription, initiation
HM989_RS01480	COG3591	Belongs to the peptidase S1B family
HM989_RS01550	COG0598	Magnesium transport protein CorA
HM989_RS01565	COG0424	maF-like protein
HM989_RS01600	COG1970	mechanosensitive ion channel activity
HM989_RS01605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HM989_RS01605	COG1333	cytochrome c biogenesis protein
HM989_RS01610	COG0626	cystathionine gamma-synthase activity
HM989_RS01620	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HM989_RS01625	COG0490	domain, Protein
HM989_RS01625	COG0471	metal ion transport
HM989_RS01630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HM989_RS01640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM989_RS01650	COG1132	(ABC) transporter
HM989_RS01655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM989_RS01660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HM989_RS01670	COG1862	Preprotein translocase
HM989_RS01675	COG4771	TonB-dependent receptor
HM989_RS01680	COG3011	Protein conserved in bacteria
HM989_RS01690	COG1288	antiporter activity
HM989_RS01695	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HM989_RS01705	COG0813	purine-nucleoside phosphorylase activity
HM989_RS01725	COG0022	dehydrogenase e1 component
HM989_RS01730	COG0071	Belongs to the small heat shock protein (HSP20) family
HM989_RS01750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HM989_RS01760	COG2195	Cleaves the N-terminal amino acid of tripeptides
HM989_RS01765	COG0589	response to stress
HM989_RS01770	COG0167	dihydroorotate dehydrogenase activity
HM989_RS01820	COG0517	IMP dehydrogenase activity
HM989_RS01820	COG0516	GMP reductase activity
HM989_RS01840	COG0693	protein deglycase activity
HM989_RS01845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HM989_RS01850	COG0308	aminopeptidase N
HM989_RS01885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HM989_RS01895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HM989_RS01900	COG0714	Associated with various cellular activities
HM989_RS01920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HM989_RS01940	COG0742	ribosomal rna small subunit methyltransferase
HM989_RS01955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM989_RS01970	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HM989_RS01985	COG1454	alcohol dehydrogenase
HM989_RS02005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HM989_RS02025	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HM989_RS02035	COG1295	ribonuclease BN
HM989_RS02040	COG3279	Response regulator of the LytR AlgR family
HM989_RS02045	COG3275	phosphorelay sensor kinase activity
HM989_RS02080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HM989_RS02085	COG3279	Response regulator of the LytR AlgR family
HM989_RS02090	COG0360	Binds together with S18 to 16S ribosomal RNA
HM989_RS02095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HM989_RS02100	COG0359	binds to the 23S rRNA
HM989_RS02105	COG0584	glycerophosphoryl diester phosphodiesterase
HM989_RS02115	COG1136	(ABC) transporter
HM989_RS02115	COG0577	efflux transmembrane transporter activity
HM989_RS02120	COG0124	histidyl-tRNA synthetase
HM989_RS02125	COG4409	exo-alpha-(2->6)-sialidase activity
HM989_RS02155	COG0471	metal ion transport
HM989_RS02220	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HM989_RS02245	COG1858	cytochrome C peroxidase
HM989_RS02325	COG1678	Uncharacterized ACR, COG1678
HM989_RS02335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM989_RS02340	COG0514	ATP-dependent DNA helicase (RecQ)
HM989_RS02360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HM989_RS02375	COG0415	Belongs to the DNA photolyase family
HM989_RS02395	COG0386	Belongs to the glutathione peroxidase family
HM989_RS02400	COG0300	oxidoreductase activity
HM989_RS02410	COG0302	gtp cyclohydrolase
HM989_RS02425	COG0415	Belongs to the DNA photolyase family
HM989_RS02430	COG3046	protein related to deoxyribodipyrimidine photolyase
HM989_RS02435	COG0415	Belongs to the DNA photolyase family
HM989_RS02445	COG0702	epimerase
HM989_RS02470	COG0673	inositol 2-dehydrogenase activity
HM989_RS02500	COG0673	inositol 2-dehydrogenase activity
HM989_RS02645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM989_RS02680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HM989_RS02685	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HM989_RS02695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HM989_RS02710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HM989_RS02715	COG3959	Transketolase, thiamine diphosphate binding domain
HM989_RS02720	COG0343	queuine tRNA-ribosyltransferase activity
HM989_RS02735	COG0825	malonyl-CoA metabolic process
HM989_RS02740	COG0305	Participates in initiation and elongation during chromosome replication
HM989_RS02780	COG0561	phosphatase activity
HM989_RS02785	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HM989_RS02790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HM989_RS02795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HM989_RS02800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HM989_RS02830	COG0564	pseudouridine synthase activity
HM989_RS02835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HM989_RS02840	COG1760	l-serine dehydratase
HM989_RS02855	COG0443	Heat shock 70 kDa protein
HM989_RS02865	COG2986	histidine ammonia-lyase
HM989_RS02920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HM989_RS02925	COG1388	LysM domain
HM989_RS02925	COG0791	NLP P60 protein
HM989_RS02935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HM989_RS02955	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HM989_RS02960	COG0540	Belongs to the ATCase OTCase family
HM989_RS02970	COG1234	tRNA 3'-trailer cleavage
HM989_RS02975	COG0259	pyridoxamine-phosphate oxidase activity
HM989_RS02990	COG2885	chlorophyll binding
HM989_RS03010	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HM989_RS03025	COG2234	aminopeptidase activity
HM989_RS03060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HM989_RS03070	COG2885	chlorophyll binding
HM989_RS03095	COG0335	large ribosomal subunit rRNA binding
HM989_RS03100	COG0336	Belongs to the RNA methyltransferase TrmD family
HM989_RS03105	COG0095	Lipoate-protein ligase
HM989_RS03110	COG0596	Alpha beta hydrolase
HM989_RS03115	COG0339	signal peptide processing
HM989_RS03120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM989_RS03125	COG0494	nUDIX hydrolase
HM989_RS03145	COG1252	NADH dehydrogenase
HM989_RS03160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HM989_RS03170	COG0798	PFAM Bile acid sodium symporter
HM989_RS03200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HM989_RS03210	COG0083	homoserine kinase activity
HM989_RS03215	COG0460	homoserine dehydrogenase
HM989_RS03215	COG0527	aspartate kinase activity
HM989_RS03220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HM989_RS03225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM989_RS03230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HM989_RS03240	COG2070	2-Nitropropane dioxygenase
HM989_RS03305	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HM989_RS03315	COG2996	Protein conserved in bacteria
HM989_RS03330	COG1575	Belongs to the MenA family. Type 1 subfamily
HM989_RS03335	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HM989_RS03350	COG4948	Mandelate Racemase Muconate Lactonizing
HM989_RS03365	COG2304	oxidoreductase activity
HM989_RS03395	COG0012	GTP binding
HM989_RS03430	COG0861	Integral membrane protein TerC family
HM989_RS03450	COG1522	sequence-specific DNA binding
HM989_RS03460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HM989_RS03465	COG0506	proline dehydrogenase activity
HM989_RS03470	COG0726	polysaccharide deacetylase
HM989_RS03490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM989_RS03505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM989_RS03515	COG0367	asparagine synthase
HM989_RS03540	COG1045	serine acetyltransferase
HM989_RS03575	COG1216	Glycosyl transferase, family 2
HM989_RS03590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HM989_RS03615	COG0802	atpase or kinase
HM989_RS03620	COG2204	response regulator
HM989_RS03625	COG1078	dGTPase activity
HM989_RS03630	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM989_RS03635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM989_RS03635	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HM989_RS03640	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM989_RS03645	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HM989_RS03660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HM989_RS03665	COG1028	Short-chain dehydrogenase reductase Sdr
HM989_RS03690	COG0101	tRNA pseudouridine synthase activity
HM989_RS03705	COG0783	Belongs to the Dps family
HM989_RS03710	COG0668	transmembrane transport
HM989_RS03740	COG0668	transmembrane transport
HM989_RS03745	COG2814	Major facilitator Superfamily
HM989_RS03750	COG1278	Cold shock
HM989_RS03755	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM989_RS03770	COG4942	peptidase
HM989_RS03790	COG0484	heat shock protein binding
HM989_RS03795	COG1028	Short-chain dehydrogenase reductase Sdr
HM989_RS03810	COG0513	Belongs to the DEAD box helicase family
HM989_RS03825	COG1278	Cold shock
HM989_RS03850	COG1012	belongs to the aldehyde dehydrogenase family
HM989_RS03855	COG4221	oxidoreductase activity
HM989_RS03865	COG1902	pentaerythritol trinitrate reductase activity
HM989_RS03940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM989_RS03955	COG2135	peptidase activity
HM989_RS03965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM989_RS03970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM989_RS03990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HM989_RS04005	COG1266	CAAX protease self-immunity
HM989_RS04020	COG3275	phosphorelay sensor kinase activity
HM989_RS04035	COG1131	(ABC) transporter
HM989_RS04040	COG3275	phosphorelay sensor kinase activity
HM989_RS04050	COG3250	beta-galactosidase activity
HM989_RS04055	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM989_RS04060	COG0633	Ferredoxin
HM989_RS04060	COG0543	2 iron, 2 sulfur cluster binding
HM989_RS04080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HM989_RS04085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM989_RS04110	COG1960	acyl-CoA dehydrogenase activity
HM989_RS04130	COG2130	NADP-dependent
HM989_RS04140	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HM989_RS04145	COG2066	Belongs to the glutaminase family
HM989_RS04155	COG2308	Evidence 4 Homologs of previously reported genes of
HM989_RS04155	COG2307	Protein conserved in bacteria
HM989_RS04180	COG2308	Evidence 4 Homologs of previously reported genes of
HM989_RS04200	COG0322	excinuclease ABC activity
HM989_RS04205	COG3237	CsbD-like
HM989_RS04215	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HM989_RS04220	COG4181	ATPase activity
HM989_RS04240	COG0668	transmembrane transport
HM989_RS04245	COG1752	Esterase of the alpha-beta hydrolase superfamily
HM989_RS04300	COG2267	carboxylic ester hydrolase activity
HM989_RS04335	COG1187	pseudouridine synthase activity
HM989_RS04345	COG2897	thiosulfate sulfurtransferase activity
HM989_RS04350	COG1301	dicarboxylic acid transport
HM989_RS04360	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HM989_RS04370	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM989_RS04375	COG3657	addiction module killer protein
HM989_RS04380	COG0277	FAD linked oxidase domain protein
HM989_RS04380	COG0247	lactate metabolic process
HM989_RS04415	COG3871	stress protein (general stress protein 26)
HM989_RS04430	COG2323	membrane
HM989_RS04435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HM989_RS04450	COG2154	pterin-4-alpha-carbinolamine dehydratase
HM989_RS04455	COG0217	transcriptional regulatory protein
HM989_RS04465	COG4974	Belongs to the 'phage' integrase family
HM989_RS04500	COG1473	amidohydrolase
HM989_RS04540	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HM989_RS04555	COG1674	ftsk spoiiie
HM989_RS04570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM989_RS04570	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM989_RS04650	COG2205	protein histidine kinase activity
HM989_RS04650	COG3292	Two component regulator propeller
HM989_RS04650	COG0745	RESPONSE REGULATOR receiver
HM989_RS04655	COG3292	Two component regulator propeller
HM989_RS04655	COG0745	RESPONSE REGULATOR receiver
HM989_RS04655	COG2205	protein histidine kinase activity
HM989_RS04660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM989_RS04665	COG0778	Nitroreductase
HM989_RS04675	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HM989_RS04695	COG1984	allophanate hydrolase subunit 2
HM989_RS04700	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HM989_RS04705	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HM989_RS04745	COG0606	chelatase, subunit chli
HM989_RS04780	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HM989_RS04805	COG0513	Belongs to the DEAD box helicase family
HM989_RS04820	COG1595	DNA-templated transcription, initiation
HM989_RS04830	COG3275	phosphorelay sensor kinase activity
HM989_RS04835	COG3279	Response regulator of the LytR AlgR family
HM989_RS04845	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HM989_RS04850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HM989_RS04860	COG0626	cystathionine gamma-synthase activity
HM989_RS04870	COG1757	Na H antiporter
HM989_RS04875	COG0450	alkyl hydroperoxide reductase
HM989_RS04880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM989_RS04895	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HM989_RS04910	COG0488	(ABC) transporter
HM989_RS04920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HM989_RS04930	COG0300	oxidoreductase activity
HM989_RS04965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HM989_RS04975	COG0564	pseudouridine synthase activity
HM989_RS05000	COG0542	response to heat
HM989_RS05010	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HM989_RS05015	COG0813	purine-nucleoside phosphorylase activity
HM989_RS05030	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HM989_RS05045	COG2936	dipeptidyl-peptidase activity
HM989_RS05050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HM989_RS05055	COG0673	inositol 2-dehydrogenase activity
HM989_RS05060	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM989_RS05080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HM989_RS05085	COG2176	DNA-directed DNA polymerase activity
HM989_RS05095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HM989_RS05100	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HM989_RS05120	COG0237	dephospho-CoA kinase activity
HM989_RS05130	COG0463	Glycosyl transferase, family 2
HM989_RS05150	COG0497	DNA recombination
HM989_RS05175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HM989_RS05190	COG0737	Belongs to the 5'-nucleotidase family
HM989_RS05200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HM989_RS05210	COG2890	protein-(glutamine-N5) methyltransferase activity
HM989_RS05225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HM989_RS05225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HM989_RS05230	COG1011	Hydrolase
HM989_RS05235	COG0697	spore germination
HM989_RS05240	COG1739	Uncharacterized protein family UPF0029
HM989_RS05245	COG0824	Thioesterase
HM989_RS05250	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HM989_RS05255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HM989_RS05265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HM989_RS05280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HM989_RS05290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HM989_RS05295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HM989_RS05350	COG0667	Aldo Keto reductase
HM989_RS05445	COG2378	regulation of single-species biofilm formation
HM989_RS05460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HM989_RS05470	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HM989_RS05475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM989_RS05530	COG2382	esterase
HM989_RS05535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HM989_RS05565	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HM989_RS05580	COG2755	lipolytic protein G-D-S-L family
HM989_RS05595	COG1228	amidohydrolase
HM989_RS05605	COG0010	Belongs to the arginase family
HM989_RS05675	COG0488	(ABC) transporter
HM989_RS05685	COG1741	Belongs to the pirin family
HM989_RS05705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HM989_RS05745	COG0205	6-phosphofructokinase activity
HM989_RS05755	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HM989_RS05785	COG0628	permease
HM989_RS05805	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HM989_RS05805	COG1793	dna ligase
HM989_RS05840	COG4251	negative regulation of phosphorylation
HM989_RS05845	COG0784	Response regulator, receiver
HM989_RS05855	COG2201	protein-glutamate methylesterase activity
HM989_RS05860	COG1480	7TM receptor with intracellular HD hydrolase
HM989_RS05865	COG0183	Belongs to the thiolase family
HM989_RS05870	COG0791	NLP P60 protein
HM989_RS05875	COG3063	Type IV pilus biogenesis stability protein PilW
HM989_RS05885	COG0542	response to heat
HM989_RS05895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HM989_RS05905	COG0366	Alpha amylase catalytic
HM989_RS05910	COG3387	PFAM Glycoside hydrolase 15-related
HM989_RS05915	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HM989_RS05920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HM989_RS05925	COG0297	glycogen (starch) synthase activity
HM989_RS05930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM989_RS05945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HM989_RS05955	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HM989_RS05990	COG1418	mRNA catabolic process
HM989_RS06025	COG1104	cysteine desulfurase activity
HM989_RS06055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM989_RS06075	COG1595	DNA-templated transcription, initiation
HM989_RS06085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HM989_RS06105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HM989_RS06110	COG1702	phosphate starvation-inducible protein PhoH
HM989_RS06140	COG0592	DNA-directed DNA polymerase activity
HM989_RS06165	COG1294	oxidase, subunit
HM989_RS06170	COG1271	oxidase subunit
HM989_RS06195	COG0471	metal ion transport
HM989_RS06195	COG3273	potassium ion transport
HM989_RS06225	COG2217	Heavy metal translocating P-type atpase
HM989_RS06235	COG0701	Predicted permease
HM989_RS06245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM989_RS06290	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HM989_RS06295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM989_RS06315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HM989_RS06345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HM989_RS06345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HM989_RS06355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HM989_RS06355	COG0047	phosphoribosylformylglycinamidine synthase activity
HM989_RS06375	COG1024	Enoyl-CoA hydratase
HM989_RS06375	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM989_RS06385	COG0183	Belongs to the thiolase family
HM989_RS06395	COG1960	acyl-CoA dehydrogenase activity
HM989_RS06400	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM989_RS06425	COG2234	aminopeptidase activity
HM989_RS06430	COG0739	heme binding
HM989_RS06480	COG2217	Heavy metal translocating P-type atpase
HM989_RS06500	COG2010	Cytochrome c
HM989_RS06505	COG0348	domain, Protein
HM989_RS06530	COG0589	response to stress
HM989_RS06535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HM989_RS06540	COG2032	superoxide dismutase activity
HM989_RS06555	COG1272	protein, Hemolysin III
HM989_RS06565	COG1363	Peptidase, m42
HM989_RS06575	COG2339	peptidase activity
HM989_RS06585	COG0439	Biotin carboxylase
HM989_RS06590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HM989_RS06615	COG1132	(ABC) transporter
HM989_RS06625	COG2814	Major facilitator Superfamily
HM989_RS06630	COG0009	L-threonylcarbamoyladenylate synthase
HM989_RS06665	COG0438	transferase activity, transferring glycosyl groups
HM989_RS06670	COG1472	Belongs to the glycosyl hydrolase 3 family
HM989_RS06675	COG3830	Belongs to the UPF0237 family
HM989_RS06675	COG0560	Phosphoserine phosphatase
HM989_RS06695	COG2181	nitrate reductase activity
HM989_RS06695	COG0247	lactate metabolic process
HM989_RS06700	COG0247	lactate metabolic process
HM989_RS06700	COG2181	nitrate reductase activity
HM989_RS06705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HM989_RS06710	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM989_RS06720	COG0251	oxidation-reduction process
HM989_RS06735	COG0516	GMP reductase activity
HM989_RS06765	COG4251	negative regulation of phosphorylation
HM989_RS06775	COG1215	transferase activity, transferring glycosyl groups
HM989_RS06785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM989_RS06825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HM989_RS06830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HM989_RS06845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HM989_RS06905	COG0156	8-amino-7-oxononanoate synthase activity
HM989_RS06920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HM989_RS06955	COG1393	Belongs to the ArsC family
HM989_RS06975	COG1064	alcohol dehydrogenase
HM989_RS06980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HM989_RS06990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HM989_RS07010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM989_RS07020	COG1115	amino acid carrier protein
HM989_RS07060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HM989_RS07085	COG1120	ATPase activity
HM989_RS07090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HM989_RS07120	COG4640	response to antibiotic
HM989_RS07165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HM989_RS07170	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HM989_RS07180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HM989_RS07205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM989_RS07210	COG4166	transmembrane transport
HM989_RS07225	COG0254	rRNA binding
HM989_RS07240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HM989_RS07245	COG1132	(ABC) transporter
HM989_RS07250	COG1595	DNA-templated transcription, initiation
HM989_RS07265	COG0179	Fumarylacetoacetate (FAA) hydrolase
HM989_RS07275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HM989_RS07285	COG1611	Belongs to the LOG family
HM989_RS07320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HM989_RS07320	COG0116	Belongs to the methyltransferase superfamily
HM989_RS07325	COG2226	methyltransferase
HM989_RS07395	COG0105	UTP biosynthetic process
HM989_RS07400	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HM989_RS07410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM989_RS07415	COG2195	Cleaves the N-terminal amino acid of tripeptides
HM989_RS07440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM989_RS07445	COG0501	Belongs to the peptidase M48B family
HM989_RS07460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HM989_RS07470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HM989_RS07480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM989_RS07500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HM989_RS07515	COG3956	TIGRFAM MazG family protein
HM989_RS07525	COG0242	peptide deformylase activity
HM989_RS07530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HM989_RS07535	COG3549	Plasmid maintenance system killer
HM989_RS07545	COG2171	N-acyltransferase activity
HM989_RS07565	COG0463	Glycosyl transferase, family 2
HM989_RS07570	COG1215	transferase activity, transferring glycosyl groups
HM989_RS07575	COG0463	Glycosyl transferase, family 2
HM989_RS07590	COG0463	Glycosyl transferase, family 2
HM989_RS07630	COG0617	tRNA 3'-terminal CCA addition
HM989_RS07630	COG0517	IMP dehydrogenase activity
HM989_RS07630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HM989_RS07635	COG1612	heme a metabolic process
HM989_RS07650	COG1131	(ABC) transporter
HM989_RS07715	COG0556	nucleotide-excision repair
HM989_RS07735	COG0045	succinate-CoA ligase (ADP-forming) activity
HM989_RS07745	COG0019	diaminopimelate decarboxylase activity
HM989_RS07800	COG2326	polyphosphate kinase activity
HM989_RS07815	COG3264	Mechanosensitive ion channel
HM989_RS07815	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HM989_RS07820	COG1668	transmembrane transport
HM989_RS07825	COG4152	abc transporter atp-binding protein
HM989_RS07830	COG0484	heat shock protein binding
HM989_RS07835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HM989_RS07850	COG2197	response regulator
HM989_RS07855	COG4585	Histidine kinase
HM989_RS07865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HM989_RS07880	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HM989_RS07880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HM989_RS07885	COG1090	epimerase
HM989_RS07945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HM989_RS07995	COG2949	membrane
HM989_RS08010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM989_RS08015	COG0300	oxidoreductase activity
HM989_RS08045	COG1085	galactose-1-phosphate uridylyltransferase
HM989_RS08050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HM989_RS08060	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HM989_RS08065	COG3250	beta-galactosidase activity
HM989_RS08090	COG0697	spore germination
HM989_RS08100	COG0800	Aldolase
HM989_RS08105	COG0205	6-phosphofructokinase activity
HM989_RS08135	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HM989_RS08140	COG0085	RNA polymerase activity
HM989_RS08145	COG0222	ribosome binding
HM989_RS08150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HM989_RS08155	COG0081	regulation of translation
HM989_RS08160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HM989_RS08180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HM989_RS08205	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HM989_RS08210	COG4974	Belongs to the 'phage' integrase family
HM989_RS08225	COG1115	amino acid carrier protein
HM989_RS08230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HM989_RS08280	COG0577	efflux transmembrane transporter activity
HM989_RS08285	COG3876	Protein conserved in bacteria
HM989_RS08295	COG0584	glycerophosphoryl diester phosphodiesterase
HM989_RS08325	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HM989_RS08345	COG0159	tryptophan synthase activity
HM989_RS08380	COG4628	conserved protein (DUF2132)
HM989_RS08390	COG0513	Belongs to the DEAD box helicase family
HM989_RS08400	COG2957	Belongs to the agmatine deiminase family
HM989_RS08495	COG4251	negative regulation of phosphorylation
HM989_RS08520	COG3022	response to hydroperoxide
HM989_RS08525	COG0564	pseudouridine synthase activity
HM989_RS08535	COG1181	Belongs to the D-alanine--D-alanine ligase family
HM989_RS08540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HM989_RS08585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HM989_RS08620	COG1160	GTP binding
HM989_RS08625	COG1388	LysM domain
HM989_RS08625	COG1705	Flagellar rod assembly protein muramidase FlgJ
HM989_RS08650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HM989_RS08655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM989_RS08675	COG0793	Belongs to the peptidase S41A family
HM989_RS08675	COG4946	Tricorn protease homolog
HM989_RS08695	COG1764	response to oxidative stress
HM989_RS08725	COG4974	Belongs to the 'phage' integrase family
HM989_RS08930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HM989_RS09065	COG3547	Transposase (IS116 IS110 IS902 family)
HM989_RS09080	COG3119	arylsulfatase activity
HM989_RS09085	COG3250	beta-galactosidase activity
HM989_RS09090	COG0657	acetylesterase activity
HM989_RS09090	COG2755	lipolytic protein G-D-S-L family
HM989_RS09095	COG3119	arylsulfatase activity
HM989_RS09100	COG3119	arylsulfatase activity
HM989_RS09105	COG3408	Glycogen debranching enzyme
HM989_RS09105	COG3119	arylsulfatase activity
HM989_RS09120	COG3119	arylsulfatase activity
HM989_RS09130	COG3292	Two component regulator propeller
HM989_RS09130	COG0745	RESPONSE REGULATOR receiver
HM989_RS09130	COG0745	RESPONSE REGULATOR receiver
HM989_RS09130	COG2205	protein histidine kinase activity
HM989_RS09130	COG3292	Two component regulator propeller
HM989_RS09130	COG2205	protein histidine kinase activity
HM989_RS09135	COG4771	TonB-dependent receptor
HM989_RS09140	COG0702	epimerase
HM989_RS09150	COG3119	arylsulfatase activity
HM989_RS09160	COG1085	galactose-1-phosphate uridylyltransferase
HM989_RS09180	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HM989_RS09215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HM989_RS09225	COG2264	protein methyltransferase activity
HM989_RS09270	COG0149	triose-phosphate isomerase activity
HM989_RS09275	COG0601	transmembrane transport
HM989_RS09290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HM989_RS09315	COG1132	(ABC) transporter
HM989_RS09320	COG0101	tRNA pseudouridine synthase activity
HM989_RS09340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HM989_RS09350	COG2217	Heavy metal translocating P-type atpase
HM989_RS09365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HM989_RS09375	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HM989_RS09400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM989_RS09405	COG3174	membrane
HM989_RS09410	COG0205	6-phosphofructokinase activity
HM989_RS09420	COG1301	dicarboxylic acid transport
HM989_RS09425	COG1830	Aldolase
HM989_RS09435	COG0531	amino acid
HM989_RS09510	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HM989_RS09520	COG2132	Multicopper oxidase
HM989_RS09555	COG0701	Predicted permease
HM989_RS09570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM989_RS09580	COG2207	Transcriptional regulator
HM989_RS09625	COG2217	Heavy metal translocating P-type atpase
HM989_RS09635	COG2217	Heavy metal translocating P-type atpase
HM989_RS09845	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HM989_RS09850	COG1074	ATP-dependent DNA helicase activity
HM989_RS09910	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HM989_RS09910	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HM989_RS10045	COG0488	(ABC) transporter
HM989_RS10055	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HM989_RS10055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HM989_RS10075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM989_RS10100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM989_RS10135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HM989_RS10140	COG0459	protein refolding
HM989_RS10180	COG1956	GAF domain-containing protein
HM989_RS10195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HM989_RS10205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HM989_RS10210	COG0563	adenylate kinase activity
HM989_RS10215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HM989_RS10230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HM989_RS10275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HM989_RS10275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HM989_RS10280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM989_RS10290	COG1215	transferase activity, transferring glycosyl groups
HM989_RS10330	COG2274	protein secretion by the type I secretion system
HM989_RS10360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HM989_RS10365	COG1127	ABC transporter
HM989_RS10400	COG0484	heat shock protein binding
HM989_RS10410	COG1028	Short-chain dehydrogenase reductase Sdr
HM989_RS10420	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM989_RS10430	COG0295	cytidine deaminase activity
HM989_RS10445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM989_RS10450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HM989_RS10455	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HM989_RS10480	COG0285	dihydrofolate synthase activity
HM989_RS10490	COG0848	biopolymer transport protein
HM989_RS10495	COG0811	peptide transport
HM989_RS10500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HM989_RS10515	COG1960	acyl-CoA dehydrogenase activity
HM989_RS10520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM989_RS10570	COG0702	epimerase
HM989_RS10575	COG1629	transport
HM989_RS10580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HM989_RS10605	COG0321	lipoyl(octanoyl) transferase activity
HM989_RS10615	COG0401	homolog of Blt101
HM989_RS10620	COG2197	response regulator
HM989_RS10635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HM989_RS10680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HM989_RS10690	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HM989_RS10715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HM989_RS10725	COG0659	secondary active sulfate transmembrane transporter activity
HM989_RS10730	COG1278	Cold shock
HM989_RS10735	COG2076	Multidrug Resistance protein
HM989_RS10750	COG0358	DNA primase activity
HM989_RS10755	COG2197	response regulator
HM989_RS10760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HM989_RS10805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HM989_RS10815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HM989_RS10820	COG3396	Phenylacetate-CoA oxygenase
HM989_RS10830	COG3460	Phenylacetate-CoA oxygenase
HM989_RS10835	COG3396	Phenylacetate-CoA oxygenase
HM989_RS10840	COG2151	metal-sulfur cluster biosynthetic enzyme
HM989_RS10845	COG1024	Enoyl-CoA hydratase
HM989_RS10850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HM989_RS10855	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM989_RS10865	COG2321	neutral zinc metallopeptidase
HM989_RS10870	COG0183	Belongs to the thiolase family
HM989_RS10875	COG1012	belongs to the aldehyde dehydrogenase family
HM989_RS10875	COG2030	dehydratase
HM989_RS10900	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM989_RS10905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HM989_RS10910	COG0022	dehydrogenase e1 component
HM989_RS10925	COG1595	DNA-templated transcription, initiation
HM989_RS10940	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HM989_RS10950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HM989_RS10955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HM989_RS10975	COG1988	membrane-bound metal-dependent
HM989_RS10980	COG1490	D-aminoacyl-tRNA deacylase activity
HM989_RS10985	COG1162	GTPase activity
HM989_RS10995	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HM989_RS11000	COG0287	Prephenate dehydrogenase
HM989_RS11005	COG0436	Aminotransferase
HM989_RS11010	COG0077	Prephenate dehydratase
HM989_RS11010	COG1605	Chorismate mutase
HM989_RS11015	COG1131	(ABC) transporter
HM989_RS11020	COG0857	belongs to the CobB CobQ family
HM989_RS11020	COG0280	phosphate acetyltransferase
HM989_RS11025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HM989_RS11045	COG1045	serine acetyltransferase
HM989_RS11050	COG0492	ferredoxin-NADP+ reductase activity
HM989_RS11060	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HM989_RS11070	COG1959	2 iron, 2 sulfur cluster binding
HM989_RS11075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HM989_RS11085	COG1131	(ABC) transporter
HM989_RS11090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HM989_RS11100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HM989_RS11110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HM989_RS11120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HM989_RS11125	COG2086	electron transfer activity
HM989_RS11130	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM989_RS11130	COG0022	dehydrogenase e1 component
HM989_RS11160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HM989_RS11165	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HM989_RS11215	COG1428	Deoxynucleoside kinase
HM989_RS11220	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HM989_RS11235	COG3174	membrane
HM989_RS11240	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HM989_RS11245	COG0110	maltose O-acetyltransferase activity
HM989_RS11250	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HM989_RS11255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HM989_RS11265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM989_RS11270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HM989_RS11300	COG4242	Belongs to the peptidase S51 family
HM989_RS11315	COG0702	epimerase
HM989_RS11320	COG4771	TonB-dependent receptor
HM989_RS11345	COG1609	Transcriptional regulator
HM989_RS11360	COG2211	Major facilitator Superfamily
HM989_RS11405	COG0702	epimerase
HM989_RS11410	COG4771	TonB-dependent receptor
HM989_RS11425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HM989_RS11450	COG0463	Glycosyl transferase, family 2
HM989_RS11460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM989_RS11495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM989_RS11500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM989_RS11530	COG1131	(ABC) transporter
HM989_RS11555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM989_RS11570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM989_RS11575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM989_RS11580	COG1028	Short-chain dehydrogenase reductase Sdr
HM989_RS11595	COG2755	lipolytic protein G-D-S-L family
HM989_RS11595	COG0657	acetylesterase activity
HM989_RS11600	COG2755	lipolytic protein G-D-S-L family
HM989_RS11615	COG0673	inositol 2-dehydrogenase activity
HM989_RS11620	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HM989_RS11665	COG4771	TonB-dependent receptor
HM989_RS11670	COG0702	epimerase
HM989_RS11695	COG2721	sulfolactate sulfo-lyase activity
HM989_RS11700	COG0246	Mannitol dehydrogenase
HM989_RS11715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HM989_RS11720	COG1904	glucuronate isomerase
HM989_RS11725	COG1028	Short-chain dehydrogenase reductase Sdr
HM989_RS11730	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HM989_RS11745	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HM989_RS11755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HM989_RS11760	COG1428	Deoxynucleoside kinase
HM989_RS11780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HM989_RS11785	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HM989_RS11795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HM989_RS11815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HM989_RS11825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HM989_RS11835	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HM989_RS11840	COG0596	Alpha beta hydrolase
HM989_RS11845	COG1950	PFAM Membrane protein of
HM989_RS11850	COG0544	peptidyl-prolyl cis-trans isomerase activity
HM989_RS11855	COG0740	serine-type endopeptidase activity
HM989_RS11860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HM989_RS11890	COG2972	Histidine kinase
HM989_RS11890	COG0745	RESPONSE REGULATOR receiver
HM989_RS11915	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HM989_RS11925	COG0668	transmembrane transport
HM989_RS11930	COG1214	PFAM Peptidase M22, glycoprotease
HM989_RS11945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM989_RS11950	COG0577	efflux transmembrane transporter activity
HM989_RS11950	COG1136	(ABC) transporter
HM989_RS11955	COG1136	(ABC) transporter
HM989_RS11955	COG0577	efflux transmembrane transporter activity
HM989_RS11960	COG1136	(ABC) transporter
HM989_RS11970	COG2322	membrane
HM989_RS11975	COG1999	signal sequence binding
HM989_RS11995	COG1845	cytochrome c oxidase, subunit III
HM989_RS12000	COG0109	protoheme IX farnesyltransferase activity
HM989_RS12035	COG0509	glycine decarboxylation via glycine cleavage system
HM989_RS12045	COG0632	four-way junction helicase activity
HM989_RS12050	COG0281	malic enzyme
HM989_RS12050	COG0280	phosphate acetyltransferase
HM989_RS12070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HM989_RS12085	COG1609	Transcriptional regulator
HM989_RS12090	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HM989_RS12105	COG3292	Two component regulator propeller
HM989_RS12105	COG2205	protein histidine kinase activity
HM989_RS12105	COG0745	RESPONSE REGULATOR receiver
HM989_RS12110	COG2124	cytochrome p450
HM989_RS12115	COG2255	four-way junction helicase activity
HM989_RS12120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HM989_RS12125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HM989_RS12150	COG0437	4 iron, 4 sulfur cluster binding
HM989_RS12175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HM989_RS12180	COG0195	Participates in both transcription termination and antitermination
HM989_RS12185	COG0779	Required for maturation of 30S ribosomal subunits
HM989_RS12210	COG3118	belongs to the thioredoxin family
HM989_RS12220	COG4585	Histidine kinase
HM989_RS12225	COG3279	Response regulator of the LytR AlgR family
HM989_RS12260	COG0189	ligase activity
HM989_RS12260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HM989_RS12265	COG4242	Belongs to the peptidase S51 family
HM989_RS12275	COG3292	Two component regulator propeller
HM989_RS12275	COG2205	protein histidine kinase activity
HM989_RS12275	COG0745	RESPONSE REGULATOR receiver
HM989_RS12295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM989_RS12295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM989_RS12340	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HM989_RS12355	COG1032	radical SAM domain protein
HM989_RS12360	COG0488	(ABC) transporter
HM989_RS12365	COG4771	TonB-dependent receptor
HM989_RS12390	COG0009	L-threonylcarbamoyladenylate synthase
HM989_RS12395	COG0589	response to stress
HM989_RS12400	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HM989_RS12405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HM989_RS12410	COG0052	Belongs to the universal ribosomal protein uS2 family
HM989_RS12415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HM989_RS12420	COG0528	UMP kinase activity
HM989_RS12425	COG0233	cytoplasmic translational termination
HM989_RS12440	COG0017	Asparaginyl-tRNA synthetase
HM989_RS12445	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HM989_RS12475	COG0811	peptide transport
HM989_RS12485	COG0252	asparaginase activity
HM989_RS12490	COG0084	hydrolase, TatD family'
HM989_RS12505	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM989_RS12530	COG1309	transcriptional regulator
HM989_RS12545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HM989_RS12550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HM989_RS12565	COG1278	Cold shock
HM989_RS12575	COG0590	tRNA wobble adenosine to inosine editing
HM989_RS12580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HM989_RS12590	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HM989_RS12595	COG4771	TonB-dependent receptor
HM989_RS12645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HM989_RS12650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HM989_RS12650	COG1328	CTP reductase activity
HM989_RS12655	COG3279	Response regulator of the LytR AlgR family
HM989_RS12660	COG3275	phosphorelay sensor kinase activity
HM989_RS12670	COG2095	MarC family integral membrane protein
HM989_RS12720	COG0793	Belongs to the peptidase S41A family
HM989_RS12740	COG1410	methionine synthase
HM989_RS12740	COG0646	methionine synthase
HM989_RS12750	COG0646	methionine synthase
HM989_RS12750	COG1410	methionine synthase
HM989_RS12755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HM989_RS12760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM989_RS12765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HM989_RS12775	COG0314	molybdopterin synthase activity
HM989_RS12790	COG1648	precorrin-2 dehydrogenase activity
HM989_RS12790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HM989_RS12795	COG0746	molybdenum cofactor guanylyltransferase activity
HM989_RS12800	COG0730	response to heat
HM989_RS12800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HM989_RS12810	COG0303	'Molybdopterin
HM989_RS12825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HM989_RS12830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HM989_RS12835	COG0193	aminoacyl-tRNA hydrolase activity
HM989_RS12845	COG0196	riboflavin kinase activity
HM989_RS12855	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HM989_RS12870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HM989_RS12875	COG2239	Acts as a magnesium transporter
HM989_RS12885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM989_RS12890	COG1233	COG1233 Phytoene dehydrogenase and related
HM989_RS12895	COG2197	response regulator
HM989_RS12925	COG0527	aspartate kinase activity
HM989_RS12935	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HM989_RS12945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HM989_RS12960	COG1652	LysM domain
HM989_RS12970	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HM989_RS12990	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HM989_RS13010	COG0288	reversible hydration of carbon dioxide
HM989_RS13015	COG0659	secondary active sulfate transmembrane transporter activity
HM989_RS13035	COG0659	secondary active sulfate transmembrane transporter activity
HM989_RS13065	COG2304	oxidoreductase activity
HM989_RS13080	COG0714	Associated with various cellular activities
HM989_RS13095	COG4989	oxidoreductase activity
HM989_RS13120	COG1012	belongs to the aldehyde dehydrogenase family
HM989_RS13150	COG4953	penicillin-binding protein 1C
HM989_RS13200	COG0612	Peptidase, M16
HM989_RS13205	COG0612	Peptidase, M16
HM989_RS13210	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HM989_RS13215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HM989_RS13225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HM989_RS13230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HM989_RS13240	COG1053	succinate dehydrogenase
HM989_RS13260	COG0006	proline dipeptidase activity
HM989_RS13285	COG0527	aspartate kinase activity
HM989_RS13310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HM989_RS13320	COG0316	Belongs to the HesB IscA family
HM989_RS13325	COG0719	Fe-S assembly protein
HM989_RS13340	COG0396	ATPase activity
HM989_RS13345	COG0719	Fe-S assembly protein
HM989_RS13370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HM989_RS13380	COG2166	iron-sulfur cluster assembly
HM989_RS13385	COG2151	metal-sulfur cluster biosynthetic enzyme
HM989_RS13415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HM989_RS13440	COG2954	triphosphatase activity
HM989_RS13445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HM989_RS13455	COG0469	pyruvate kinase activity
HM989_RS13465	COG0571	ribonuclease III activity
HM989_RS13470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM989_RS13475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM989_RS13480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HM989_RS13485	COG0328	RNA-DNA hybrid ribonuclease activity
HM989_RS13485	COG3341	Caulimovirus viroplasmin
HM989_RS13520	COG1074	ATP-dependent DNA helicase activity
HM989_RS13525	COG0156	8-amino-7-oxononanoate synthase activity
HM989_RS13545	COG2205	protein histidine kinase activity
HM989_RS13545	COG0784	Response regulator, receiver
HM989_RS13585	COG0720	synthase
HM989_RS13590	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM989_RS13610	COG2885	chlorophyll binding
HM989_RS13610	COG3047	cAMP biosynthetic process
HM989_RS13615	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HM989_RS13615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HM989_RS13635	COG1573	uracil-dna glycosylase
HM989_RS13650	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HM989_RS13665	COG1435	thymidine kinase activity
HM989_RS13670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HM989_RS13675	COG1970	mechanosensitive ion channel activity
HM989_RS13680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HM989_RS13685	COG1505	serine-type exopeptidase activity
HM989_RS13705	COG3842	ATPase activity
HM989_RS13735	COG3541	Predicted nucleotidyltransferase
HM989_RS13750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM989_RS13760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM989_RS13765	COG3424	synthase
HM989_RS13780	COG2353	YceI-like domain
HM989_RS13790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HM989_RS13795	COG2022	thiamine diphosphate biosynthetic process
HM989_RS13795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HM989_RS13805	COG0439	Biotin carboxylase
HM989_RS13810	COG0511	ligase activity, forming carbon-carbon bonds
HM989_RS13815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM989_RS13820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HM989_RS13830	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HM989_RS13855	COG0489	protein tyrosine kinase activity
HM989_RS13855	COG3206	protein involved in exopolysaccharide biosynthesis
HM989_RS13860	COG1215	transferase activity, transferring glycosyl groups
HM989_RS13880	COG1216	Glycosyl transferase, family 2
HM989_RS13905	COG2089	acid synthase
HM989_RS13915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM989_RS13945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM989_RS13950	COG1086	Polysaccharide biosynthesis protein
HM989_RS13955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM989_RS14000	COG0346	lactoylglutathione lyase activity
HM989_RS14005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HM989_RS14015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HM989_RS14030	COG2234	aminopeptidase activity
HM989_RS14045	COG0481	GTPase activity
HM989_RS14050	COG3263	regulation of cellular component size
HM989_RS14060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HM989_RS14080	COG0594	ribonuclease P activity
HM989_RS14085	COG0793	Belongs to the peptidase S41A family
HM989_RS14095	COG2153	protein acetylation
HM989_RS14105	COG0698	ribose 5-phosphate isomerase
HM989_RS14120	COG0557	exoribonuclease II activity
HM989_RS14125	COG0393	Putative heavy-metal-binding
HM989_RS14165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HM989_RS14195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HM989_RS14205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HM989_RS14210	COG0445	tRNA wobble uridine modification
HM989_RS14230	COG0470	DNA polymerase III
HM989_RS14235	COG0126	phosphoglycerate kinase activity
HM989_RS14240	COG1388	LysM domain
HM989_RS14240	COG0791	NLP P60 protein
HM989_RS14250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HM989_RS14280	COG1091	dTDP-4-dehydrorhamnose reductase activity
HM989_RS14290	COG1696	Membrane protein involved in D-alanine export
HM989_RS14300	COG2244	polysaccharide biosynthetic process
HM989_RS14320	COG0297	glycogen (starch) synthase activity
HM989_RS14325	COG0110	maltose O-acetyltransferase activity
HM989_RS14330	COG0297	glycogen (starch) synthase activity
HM989_RS14350	COG0151	Belongs to the GarS family
HM989_RS14365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HM989_RS14375	COG0859	PFAM glycosyl transferase family 9
HM989_RS14380	COG0633	Ferredoxin
HM989_RS14430	COG0356	it plays a direct role in the translocation of protons across the membrane
HM989_RS14435	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HM989_RS14440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HM989_RS14445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HM989_RS14450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HM989_RS14460	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HM989_RS14500	COG0756	dUTP diphosphatase activity
HM989_RS14505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HM989_RS14530	COG1607	acyl-coa hydrolase
HM989_RS14540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HM989_RS14540	COG0758	DNA mediated transformation
HM989_RS14570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HM989_RS14580	COG0739	heme binding
HM989_RS14580	COG0741	lytic transglycosylase activity
HM989_RS14580	COG1196	nuclear chromosome segregation
HM989_RS14585	COG1774	PSP1 C-terminal conserved region
HM989_RS14595	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HM989_RS14600	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HM989_RS14625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HM989_RS14630	COG1253	flavin adenine dinucleotide binding
HM989_RS14640	COG1522	sequence-specific DNA binding
HM989_RS14645	COG0113	porphobilinogen synthase activity
HM989_RS14655	COG0408	coproporphyrinogen oxidase activity
HM989_RS14670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HM989_RS14675	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HM989_RS14685	COG0181	hydroxymethylbilane synthase activity
HM989_RS14690	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HM989_RS14715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HM989_RS14725	COG1981	membrane
HM989_RS14730	COG5000	phosphorelay sensor kinase activity
HM989_RS14735	COG1024	Enoyl-CoA hydratase
HM989_RS14740	COG3177	Filamentation induced by cAMP protein fic
HM989_RS14760	COG2207	Transcriptional regulator
HM989_RS14770	COG1418	mRNA catabolic process
HM989_RS14795	COG0484	heat shock protein binding
HM989_RS14800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HM989_RS14805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HM989_RS14820	COG1121	(ABC) transporter
HM989_RS14825	COG0803	Belongs to the bacterial solute-binding protein 9 family
HM989_RS14860	COG1999	signal sequence binding
HM989_RS14905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM989_RS14925	COG0517	IMP dehydrogenase activity
HM989_RS14925	COG0516	GMP reductase activity
HM989_RS14935	COG0629	single-stranded DNA binding
HM989_RS14960	COG1473	amidohydrolase
HM989_RS14970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HM989_RS14975	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HM989_RS14980	COG2080	2 iron, 2 sulfur cluster binding
HM989_RS15075	COG1595	DNA-templated transcription, initiation
HM989_RS15080	COG3712	iron ion homeostasis
HM989_RS15090	COG0123	including yeast histone deacetylase and acetoin utilization protein
HM989_RS15095	COG2183	response to ionizing radiation
HM989_RS15120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM989_RS15120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM989_RS15125	COG1619	proteins homologs of microcin C7 resistance protein MccF
HM989_RS15135	COG0792	nuclease activity
HM989_RS15145	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HM989_RS15150	COG0194	GDP metabolic process
HM989_RS15155	COG1561	YicC-like family, N-terminal region
HM989_RS15170	COG0697	spore germination
HM989_RS15195	COG0626	cystathionine gamma-synthase activity
HM989_RS15205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM989_RS15215	COG1381	Involved in DNA repair and RecF pathway recombination
HM989_RS15250	COG2268	Band 7 protein
HM989_RS15280	COG3655	Transcriptional regulator
HM989_RS15290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HM989_RS15295	COG0587	DNA-directed DNA polymerase activity
HM989_RS15300	COG1752	Esterase of the alpha-beta hydrolase superfamily
HM989_RS15305	COG0322	excinuclease ABC activity
HM989_RS15310	COG0189	ligase activity
HM989_RS15310	COG4067	protein conserved in archaea
HM989_RS15315	COG0189	ligase activity
HM989_RS15325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HM989_RS15330	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HM989_RS15340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HM989_RS15365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HM989_RS15375	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HM989_RS15395	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HM989_RS15400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HM989_RS15405	COG0297	glycogen (starch) synthase activity
HM989_RS15415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HM989_RS15420	COG4206	TonB-dependent receptor
HM989_RS15420	COG1629	transport
HM989_RS15445	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HM989_RS15455	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HM989_RS15465	COG3483	tryptophan 2,3-dioxygenase activity
HM989_RS15475	COG0166	Belongs to the GPI family
HM989_RS15480	COG4771	TonB-dependent receptor
HM989_RS15505	COG1194	a g-specific adenine glycosylase
HM989_RS15510	COG0776	regulation of translation
HM989_RS15515	COG1530	ribonuclease E activity
HM989_RS15520	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HM989_RS15530	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HM989_RS15570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM989_RS15585	COG2827	Endonuclease containing a URI domain
HM989_RS15590	COG3852	Histidine kinase
HM989_RS15595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HM989_RS15605	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HM989_RS15610	COG0519	Catalyzes the synthesis of GMP from XMP
HM989_RS15625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HM989_RS15630	COG1968	undecaprenyl-diphosphatase activity
HM989_RS15640	COG2177	Part of the ABC transporter FtsEX involved in
HM989_RS15645	COG0495	leucyl-tRNA aminoacylation
HM989_RS15690	COG4717	serine-type aminopeptidase activity
HM989_RS15700	COG0436	Aminotransferase
HM989_RS15715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HM989_RS15725	COG1040	competence protein
HM989_RS15735	COG0423	glycine-tRNA ligase activity
HM989_RS15745	COG2072	flavoprotein involved in K transport
HM989_RS15755	COG0708	Exodeoxyribonuclease III
HM989_RS15760	COG1360	Flagellar Motor Protein
HM989_RS15765	COG0667	Aldo Keto reductase
HM989_RS15775	COG1522	sequence-specific DNA binding
HM989_RS15790	COG2363	Small membrane protein
HM989_RS15795	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HM989_RS15810	COG0463	Glycosyl transferase, family 2
HM989_RS15815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM989_RS15825	COG1090	epimerase
HM989_RS15830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HM989_RS15855	COG0745	RESPONSE REGULATOR receiver
HM989_RS15860	COG5002	protein histidine kinase activity
HM989_RS15865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HM989_RS15870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HM989_RS15885	COG0489	protein tyrosine kinase activity
HM989_RS15890	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HM989_RS15895	COG0492	ferredoxin-NADP+ reductase activity
HM989_RS15900	COG0633	Ferredoxin
HM989_RS15920	COG0628	permease
HM989_RS15925	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HM989_RS15930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HM989_RS15935	COG0228	four-way junction DNA binding
HM989_RS16015	COG2839	Protein conserved in bacteria
HM989_RS16055	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HM989_RS16060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HM989_RS16080	COG2315	Protein conserved in bacteria
HM989_RS16090	COG0784	Response regulator, receiver
HM989_RS16100	COG4251	negative regulation of phosphorylation
HM989_RS16110	COG5002	protein histidine kinase activity
HM989_RS16120	COG3279	Response regulator of the LytR AlgR family
HM989_RS16170	COG1482	cell wall glycoprotein biosynthetic process
HM989_RS16175	COG2824	Alkylphosphonate utilization operon protein PhnA
HM989_RS16230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HM989_RS16240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HM989_RS16245	COG1085	galactose-1-phosphate uridylyltransferase
HM989_RS16255	COG1472	Belongs to the glycosyl hydrolase 3 family
HM989_RS16265	COG1304	FMN binding
HM989_RS16275	COG4952	isomerase
HM989_RS16280	COG1028	Short-chain dehydrogenase reductase Sdr
HM989_RS16280	COG3347	Dehydrogenase
HM989_RS16295	COG0702	epimerase
HM989_RS16300	COG4771	TonB-dependent receptor
HM989_RS16305	COG3250	beta-galactosidase activity
HM989_RS16325	COG3119	arylsulfatase activity
HM989_RS16330	COG3250	beta-galactosidase activity
HM989_RS16355	COG2205	protein histidine kinase activity
HM989_RS16355	COG3292	Two component regulator propeller
HM989_RS16355	COG0745	RESPONSE REGULATOR receiver
HM989_RS16365	COG4771	TonB-dependent receptor
HM989_RS16370	COG0702	epimerase
HM989_RS16390	COG3119	arylsulfatase activity
HM989_RS16405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HM989_RS16410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HM989_RS16430	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM989_RS16435	COG2160	L-arabinose isomerase activity
HM989_RS16440	COG1609	Transcriptional regulator
HM989_RS16445	COG0561	phosphatase activity
HM989_RS16450	COG1475	DNA binding
HM989_RS16465	COG0629	single-stranded DNA binding
HM989_RS16545	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM989_RS16545	COG1388	LysM domain
HM989_RS16600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HM989_RS16630	COG2207	Transcriptional regulator
HM989_RS16655	COG1629	transport
HM989_RS16700	COG2188	Transcriptional regulator
HM989_RS16705	COG1070	Carbohydrate kinase
HM989_RS16710	COG2115	Belongs to the xylose isomerase family
HM989_RS16715	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HM989_RS16720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HM989_RS16725	COG2192	nodulation
HM989_RS16735	COG1028	Short-chain dehydrogenase reductase Sdr
HM989_RS16740	COG1312	Catalyzes the dehydration of D-mannonate
HM989_RS16745	COG1312	Catalyzes the dehydration of D-mannonate
HM989_RS16765	COG1069	ribulokinase activity
HM989_RS16775	COG2160	L-arabinose isomerase activity
HM989_RS16785	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM989_RS16800	COG3507	Belongs to the glycosyl hydrolase 43 family
HM989_RS16805	COG1472	Belongs to the glycosyl hydrolase 3 family
HM989_RS16810	COG3507	Belongs to the glycosyl hydrolase 43 family
HM989_RS16845	COG0667	Aldo Keto reductase
HM989_RS16865	COG5520	Belongs to the glycosyl hydrolase 30 family
HM989_RS16880	COG0702	epimerase
HM989_RS16885	COG4771	TonB-dependent receptor
HM989_RS16895	COG2211	Major facilitator Superfamily
HM989_RS16910	COG3661	Belongs to the glycosyl hydrolase 67 family
HM989_RS16915	COG1472	Belongs to the glycosyl hydrolase 3 family
HM989_RS16930	COG1609	Transcriptional regulator
HM989_RS16935	COG1331	Highly conserved protein containing a thioredoxin domain
HM989_RS16950	COG3386	PFAM SMP-30 Gluconolaconase
HM989_RS16975	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HM989_RS16980	COG4206	TonB-dependent receptor
HM989_RS16980	COG1629	transport
HM989_RS16995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HM989_RS17000	COG1554	hydrolase, family 65, central catalytic
HM989_RS17005	COG0366	Alpha amylase catalytic
HM989_RS17010	COG1501	Belongs to the glycosyl hydrolase 31 family
HM989_RS17015	COG1523	belongs to the glycosyl hydrolase 13 family
HM989_RS17025	COG0366	Alpha amylase catalytic
HM989_RS17030	COG1082	Xylose isomerase domain protein TIM barrel
HM989_RS17050	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HM989_RS17070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM989_RS17090	COG2081	HI0933 family
HM989_RS17095	COG2205	protein histidine kinase activity
HM989_RS17095	COG0784	Response regulator, receiver
HM989_RS17135	COG1187	pseudouridine synthase activity
HM989_RS17195	COG1166	arginine decarboxylase activity
HM989_RS17200	COG0010	Belongs to the arginase family
HM989_RS17205	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HM989_RS17210	COG3153	acetyltransferase
HM989_RS17210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HM989_RS17235	COG1215	transferase activity, transferring glycosyl groups
HM989_RS17240	COG0463	Glycosyl transferase, family 2
HM989_RS17255	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM989_RS17265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HM989_RS17305	COG2226	methyltransferase
HM989_RS17310	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HM989_RS17335	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HM989_RS17335	COG3608	succinylglutamate desuccinylase aspartoacylase
HM989_RS17350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HM989_RS17365	COG0590	tRNA wobble adenosine to inosine editing
HM989_RS17385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HM989_RS17400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HM989_RS17405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HM989_RS17410	COG0066	3-isopropylmalate dehydratase activity
HM989_RS17420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HM989_RS17425	COG0004	ammonium transporteR
HM989_RS17430	COG0347	Belongs to the P(II) protein family
HM989_RS17435	COG0004	ammonium transporteR
HM989_RS17445	COG0070	glutamate synthase
HM989_RS17445	COG0067	glutamate synthase
HM989_RS17445	COG0069	glutamate synthase activity
HM989_RS17455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HM989_RS17455	COG0140	phosphoribosyl-ATP diphosphatase activity
HM989_RS17460	COG0107	imidazoleglycerol-phosphate synthase activity
HM989_RS17465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HM989_RS17470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HM989_RS17475	COG0131	Imidazoleglycerol-phosphate dehydratase
HM989_RS17485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HM989_RS17490	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HM989_RS17495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HM989_RS17500	COG0165	Argininosuccinate lyase
HM989_RS17510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HM989_RS17515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HM989_RS17520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM989_RS17530	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HM989_RS17535	COG0137	argininosuccinate synthase activity
HM989_RS17545	COG1012	belongs to the aldehyde dehydrogenase family
HM989_RS17550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HM989_RS17555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HM989_RS17565	COG0028	Belongs to the TPP enzyme family
HM989_RS17570	COG0129	dihydroxy-acid dehydratase activity
HM989_RS17575	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM989_RS17585	COG1629	transport
HM989_RS17590	COG0702	epimerase
HM989_RS17630	COG3250	beta-galactosidase activity
HM989_RS17640	COG3119	arylsulfatase activity
HM989_RS17655	COG2814	Major facilitator Superfamily
HM989_RS17655	COG0477	Major facilitator Superfamily
HM989_RS17730	COG2197	response regulator
HM989_RS17755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HM989_RS17775	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HM989_RS17860	COG4974	Belongs to the 'phage' integrase family
HM989_RS18045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HM989_RS18085	COG2827	Endonuclease containing a URI domain
HM989_RS18115	COG2333	competence protein COMEC
HM989_RS18115	COG0658	competence protein
HM989_RS18120	COG0791	NLP P60 protein
HM989_RS18125	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM989_RS18130	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HM989_RS18135	COG0793	Belongs to the peptidase S41A family
HM989_RS18140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HM989_RS18145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HM989_RS18150	COG2267	carboxylic ester hydrolase activity
HM989_RS18155	COG2001	Belongs to the MraZ family
HM989_RS18160	COG0275	rRNA processing
HM989_RS18170	COG0768	penicillin binding
HM989_RS18175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HM989_RS18180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM989_RS18190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HM989_RS18195	COG0772	Belongs to the SEDS family
HM989_RS18200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HM989_RS18205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HM989_RS18220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HM989_RS18225	COG1610	YqeY-like protein
HM989_RS18550	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HM989_RS18565	COG2132	Multicopper oxidase
HM989_RS18585	COG2217	Heavy metal translocating P-type atpase
HM989_RS18595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM989_RS18655	COG3781	membrane
HM989_RS18670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HM989_RS18685	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HM989_RS18690	COG0589	response to stress
HM989_RS18695	COG2217	Heavy metal translocating P-type atpase
HM989_RS18705	COG1252	NADH dehydrogenase
HM989_RS18740	COG2095	MarC family integral membrane protein
HM989_RS18745	COG0531	amino acid
HM989_RS18765	COG0671	phosphoesterase, PA-phosphatase related
HM989_RS18770	COG0745	RESPONSE REGULATOR receiver
HM989_RS18775	COG3850	Histidine kinase
HM989_RS18775	COG5002	protein histidine kinase activity
HM989_RS18810	COG0463	Glycosyl transferase, family 2
HM989_RS18815	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM989_RS18815	COG3952	Lipid A Biosynthesis
HM989_RS18885	COG1289	transmembrane transporter activity
HM989_RS18890	COG0069	glutamate synthase activity
HM989_RS18940	COG0529	Catalyzes the synthesis of activated sulfate
HM989_RS18945	COG0175	sulfate reduction
HM989_RS18960	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HM989_RS18965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM989_RS18980	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HM989_RS18990	COG2244	polysaccharide biosynthetic process
HM989_RS19010	COG1216	Glycosyl transferase, family 2
HM989_RS19010	COG1442	glycosyl transferase family 8
HM989_RS19030	COG2030	dehydratase
HM989_RS19040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM989_RS19055	COG0438	transferase activity, transferring glycosyl groups
HM989_RS19060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HM989_RS19065	COG1216	Glycosyl transferase, family 2
HM989_RS19085	COG0438	transferase activity, transferring glycosyl groups
HM989_RS19110	COG0110	maltose O-acetyltransferase activity
HM989_RS19120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM989_RS19135	COG0517	IMP dehydrogenase activity
HM989_RS19140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HM989_RS19145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HM989_RS19155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HM989_RS19160	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HM989_RS19165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HM989_RS19170	COG1215	transferase activity, transferring glycosyl groups
HM989_RS19205	COG1185	polyribonucleotide nucleotidyltransferase activity
HM989_RS19210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HM989_RS19215	COG3290	protein histidine kinase activity
HM989_RS19220	COG2205	protein histidine kinase activity
HM989_RS19230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HM989_RS19235	COG0191	fructose-bisphosphate aldolase activity
HM989_RS19245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM989_RS19255	COG2226	methyltransferase
HM989_RS19260	COG0569	domain protein
HM989_RS19280	COG0436	Aminotransferase
HM989_RS19285	COG3239	Fatty acid desaturase
HM989_RS19290	COG0357	Ribosomal RNA small subunit methyltransferase G
HM989_RS19310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM989_RS19325	COG1012	belongs to the aldehyde dehydrogenase family
HM989_RS19335	COG2967	ApaG domain
HM989_RS19340	COG0076	glutamate decarboxylase activity
HM989_RS19355	COG1805	sodium ion transport
HM989_RS19360	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HM989_RS19390	COG0531	amino acid
HM989_RS19395	COG2311	Membrane
HM989_RS19400	COG2311	Membrane
HM989_RS19405	COG2267	carboxylic ester hydrolase activity
HM989_RS19460	COG1477	protein flavinylation
HM989_RS19490	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HM989_RS19505	COG3340	Belongs to the peptidase S51 family
HM989_RS19535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HM989_RS19560	COG1028	Short-chain dehydrogenase reductase Sdr
HM989_RS19580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HM989_RS19585	COG3844	kynureninase activity
HM989_RS19615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HM989_RS19620	COG1663	tetraacyldisaccharide 4'-kinase activity
HM989_RS19625	COG0784	Response regulator, receiver
HM989_RS19625	COG2205	protein histidine kinase activity
HM989_RS19630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HM989_RS19635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HM989_RS19645	COG1216	Glycosyl transferase, family 2
HM989_RS19665	COG1595	DNA-templated transcription, initiation
HM989_RS19670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HM989_RS19675	COG0436	Aminotransferase
HM989_RS19685	COG0525	valine-tRNA ligase activity
HM989_RS19690	COG0772	Belongs to the SEDS family
HM989_RS19695	COG0768	penicillin binding
HM989_RS19710	COG1077	Cell shape determining protein MreB Mrl
HM989_RS19715	COG0138	bifunctional purine biosynthesis protein purh
HM989_RS19725	COG2373	Large extracellular alpha-helical protein
HM989_RS19750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HM989_RS19755	COG3002	Belongs to the UPF0753 family
HM989_RS19780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HM989_RS19825	COG2003	Belongs to the UPF0758 family
HM989_RS19835	COG1011	Hydrolase
HM989_RS19845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HM989_RS19855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM989_RS19865	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HM989_RS19870	COG0049	tRNA binding
HM989_RS19875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HM989_RS19880	COG0051	transcription antitermination factor activity, RNA binding
HM989_RS19885	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HM989_RS19890	COG0088	Forms part of the polypeptide exit tunnel
HM989_RS19895	COG0089	rRNA binding
HM989_RS19900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HM989_RS19905	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HM989_RS19910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HM989_RS19915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HM989_RS19920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HM989_RS19925	COG0255	Belongs to the universal ribosomal protein uL29 family
HM989_RS19930	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HM989_RS19935	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HM989_RS19940	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HM989_RS19945	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HM989_RS19950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HM989_RS19955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HM989_RS19960	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HM989_RS19965	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HM989_RS19970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HM989_RS19975	COG1841	ribosomal large subunit assembly
HM989_RS19980	COG0200	Binds to the 23S rRNA
HM989_RS19985	COG0201	protein transport
HM989_RS19990	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HM989_RS19995	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HM989_RS20000	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HM989_RS20005	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HM989_RS20010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HM989_RS20015	COG0202	RNA polymerase activity
HM989_RS20020	COG0203	ribosomal protein L17
HM989_RS20030	COG0148	phosphopyruvate hydratase activity
HM989_RS20055	COG0688	phosphatidylethanolamine metabolic process
HM989_RS20060	COG4589	Belongs to the CDS family
HM989_RS20070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HM989_RS20075	COG0799	negative regulation of ribosome biogenesis
HM989_RS20090	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HM989_RS20130	COG5002	protein histidine kinase activity
HM989_RS20135	COG4676	Protein conserved in bacteria
HM989_RS20140	COG0018	arginyl-trna synthetase
HM989_RS20150	COG2318	DinB family
HM989_RS20180	COG0433	COG0433 Predicted ATPase
HM989_RS20215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HM989_RS20220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HM989_RS20225	COG0602	queuosine metabolic process
HM989_RS20235	COG0367	asparagine synthase
HM989_RS20250	COG0187	DNA topoisomerase II activity
HM989_RS20255	COG0784	Response regulator, receiver
HM989_RS20255	COG2205	protein histidine kinase activity
HM989_RS20255	COG2198	Histidine kinase
HM989_RS20255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HM989_RS20280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HM989_RS20300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HM989_RS20305	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HM989_RS20310	COG0215	cysteine-tRNA ligase activity
HM989_RS20315	COG0302	gtp cyclohydrolase
HM989_RS20340	COG0442	prolyl-tRNA aminoacylation
HM989_RS20350	COG0268	Binds directly to 16S ribosomal RNA
HM989_RS20360	COG0673	inositol 2-dehydrogenase activity
HM989_RS20380	COG0784	Response regulator, receiver
HM989_RS20385	COG4251	negative regulation of phosphorylation
HM989_RS20420	COG2356	endonuclease I
HM989_RS20430	COG0174	glutamine synthetase
HM989_RS20450	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HM989_RS20460	COG1129	ABC transporter
HM989_RS20470	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HM989_RS20480	COG0284	orotidine-5'-phosphate decarboxylase activity
HM989_RS20485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HM989_RS20505	COG0788	formyltetrahydrofolate deformylase activity
HM989_RS20510	COG1703	isobutyryl-CoA mutase activity
HM989_RS20510	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM989_RS20510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM989_RS20530	COG1522	sequence-specific DNA binding
HM989_RS20540	COG0492	ferredoxin-NADP+ reductase activity
HM989_RS20550	COG2814	Major facilitator Superfamily
HM989_RS20565	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HM989_RS20570	COG1217	gtp-binding protein TYPA
HM989_RS20590	COG2226	methyltransferase
HM989_RS20600	COG0463	Glycosyl transferase, family 2
HM989_RS20615	COG2244	polysaccharide biosynthetic process
HM989_RS20645	COG1216	Glycosyl transferase, family 2
HM989_RS20660	COG2884	Cell division ATP-binding protein ftsE
HM989_RS20665	COG0133	tryptophan synthase activity
HM989_RS20670	COG0135	phosphoribosylanthranilate isomerase activity
HM989_RS20675	COG0134	indole-3-glycerol-phosphate synthase activity
HM989_RS20680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HM989_RS20685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HM989_RS20685	COG0512	Glutamine amidotransferase of anthranilate synthase
HM989_RS20690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HM989_RS20700	COG1846	Transcriptional regulator
HM989_RS20705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM989_RS20715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HM989_RS20765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM989_RS20770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM989_RS20775	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM989_RS20815	COG1047	Peptidyl-prolyl cis-trans
HM989_RS20825	COG1349	DNA-binding transcription factor activity
HM989_RS20830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HM989_RS20840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HM989_RS20850	COG4771	TonB-dependent receptor
HM989_RS20880	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP