locus-tag	class	description
HM988_RS00035	COG1028	Short-chain dehydrogenase reductase Sdr
HM988_RS00040	COG1028	Short-chain dehydrogenase reductase Sdr
HM988_RS00070	COG1629	transport
HM988_RS00070	COG4206	TonB-dependent receptor
HM988_RS00075	COG1621	beta-fructofuranosidase activity
HM988_RS00080	COG2814	Major facilitator Superfamily
HM988_RS00085	COG0745	RESPONSE REGULATOR receiver
HM988_RS00085	COG3292	Two component regulator propeller
HM988_RS00085	COG2205	protein histidine kinase activity
HM988_RS00120	COG0488	(ABC) transporter
HM988_RS00130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HM988_RS00150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM988_RS00175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM988_RS00205	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HM988_RS00210	COG0459	protein refolding
HM988_RS00265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HM988_RS00270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HM988_RS00275	COG0563	adenylate kinase activity
HM988_RS00280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HM988_RS00295	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HM988_RS00300	COG0339	signal peptide processing
HM988_RS00360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HM988_RS00360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HM988_RS00365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM988_RS00375	COG1215	transferase activity, transferring glycosyl groups
HM988_RS00400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HM988_RS00405	COG1127	ABC transporter
HM988_RS00430	COG2304	oxidoreductase activity
HM988_RS00455	COG0484	heat shock protein binding
HM988_RS00465	COG1028	Short-chain dehydrogenase reductase Sdr
HM988_RS00475	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM988_RS00485	COG0295	cytidine deaminase activity
HM988_RS00500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM988_RS00505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HM988_RS00510	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HM988_RS00530	COG0285	dihydrofolate synthase activity
HM988_RS00540	COG0848	biopolymer transport protein
HM988_RS00545	COG0811	peptide transport
HM988_RS00550	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HM988_RS00565	COG1960	acyl-CoA dehydrogenase activity
HM988_RS00570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM988_RS00620	COG1629	transport
HM988_RS00625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HM988_RS00650	COG0321	lipoyl(octanoyl) transferase activity
HM988_RS00660	COG0401	homolog of Blt101
HM988_RS00665	COG2197	response regulator
HM988_RS00680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HM988_RS00715	COG4682	membrane
HM988_RS00735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HM988_RS00745	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HM988_RS00770	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HM988_RS00780	COG0659	secondary active sulfate transmembrane transporter activity
HM988_RS00785	COG1278	Cold shock
HM988_RS00790	COG2076	Multidrug Resistance protein
HM988_RS00805	COG0358	DNA primase activity
HM988_RS00810	COG2197	response regulator
HM988_RS00815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HM988_RS00865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HM988_RS00870	COG3396	Phenylacetate-CoA oxygenase
HM988_RS00875	COG3460	Phenylacetate-CoA oxygenase
HM988_RS00880	COG3396	Phenylacetate-CoA oxygenase
HM988_RS00885	COG2151	metal-sulfur cluster biosynthetic enzyme
HM988_RS00890	COG1024	Enoyl-CoA hydratase
HM988_RS00900	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM988_RS00910	COG2321	neutral zinc metallopeptidase
HM988_RS00915	COG0183	Belongs to the thiolase family
HM988_RS00920	COG2030	dehydratase
HM988_RS00920	COG1012	belongs to the aldehyde dehydrogenase family
HM988_RS00940	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM988_RS00945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HM988_RS00950	COG0022	dehydrogenase e1 component
HM988_RS00965	COG1595	DNA-templated transcription, initiation
HM988_RS00980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HM988_RS00990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HM988_RS00995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HM988_RS01015	COG1988	membrane-bound metal-dependent
HM988_RS01020	COG1490	D-aminoacyl-tRNA deacylase activity
HM988_RS01025	COG1162	GTPase activity
HM988_RS01035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HM988_RS01040	COG0287	Prephenate dehydrogenase
HM988_RS01045	COG0436	Aminotransferase
HM988_RS01050	COG0077	Prephenate dehydratase
HM988_RS01050	COG1605	Chorismate mutase
HM988_RS01055	COG1131	(ABC) transporter
HM988_RS01060	COG0857	belongs to the CobB CobQ family
HM988_RS01060	COG0280	phosphate acetyltransferase
HM988_RS01065	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HM988_RS01085	COG1045	serine acetyltransferase
HM988_RS01090	COG0492	ferredoxin-NADP+ reductase activity
HM988_RS01100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HM988_RS01110	COG1959	2 iron, 2 sulfur cluster binding
HM988_RS01115	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HM988_RS01125	COG1131	(ABC) transporter
HM988_RS01130	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HM988_RS01145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HM988_RS01150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HM988_RS01160	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HM988_RS01165	COG2086	electron transfer activity
HM988_RS01170	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM988_RS01170	COG0022	dehydrogenase e1 component
HM988_RS01195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HM988_RS01200	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HM988_RS01250	COG1428	Deoxynucleoside kinase
HM988_RS01255	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HM988_RS01270	COG3174	membrane
HM988_RS01275	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HM988_RS01280	COG0110	maltose O-acetyltransferase activity
HM988_RS01285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HM988_RS01290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HM988_RS01300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM988_RS01305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HM988_RS01335	COG4242	Belongs to the peptidase S51 family
HM988_RS01350	COG0702	epimerase
HM988_RS01355	COG4771	TonB-dependent receptor
HM988_RS01400	COG1609	Transcriptional regulator
HM988_RS01415	COG2211	Major facilitator Superfamily
HM988_RS01460	COG0702	epimerase
HM988_RS01465	COG4771	TonB-dependent receptor
HM988_RS01480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HM988_RS01505	COG4680	protein conserved in bacteria
HM988_RS01520	COG0463	Glycosyl transferase, family 2
HM988_RS01530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM988_RS01560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM988_RS01565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM988_RS01595	COG1131	(ABC) transporter
HM988_RS01610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM988_RS01620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM988_RS01635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM988_RS01640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM988_RS01645	COG1028	Short-chain dehydrogenase reductase Sdr
HM988_RS01665	COG2755	lipolytic protein G-D-S-L family
HM988_RS01665	COG0657	acetylesterase activity
HM988_RS01670	COG2755	lipolytic protein G-D-S-L family
HM988_RS01685	COG0673	inositol 2-dehydrogenase activity
HM988_RS01690	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HM988_RS01735	COG4771	TonB-dependent receptor
HM988_RS01740	COG0702	epimerase
HM988_RS01765	COG2721	sulfolactate sulfo-lyase activity
HM988_RS01770	COG0246	Mannitol dehydrogenase
HM988_RS01785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HM988_RS01790	COG1904	glucuronate isomerase
HM988_RS01795	COG1028	Short-chain dehydrogenase reductase Sdr
HM988_RS01800	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HM988_RS01815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HM988_RS01825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HM988_RS01830	COG1428	Deoxynucleoside kinase
HM988_RS01850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HM988_RS01855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HM988_RS01865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HM988_RS01885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HM988_RS01895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HM988_RS01905	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HM988_RS01910	COG0596	Alpha beta hydrolase
HM988_RS01920	COG1950	PFAM Membrane protein of
HM988_RS01925	COG0544	peptidyl-prolyl cis-trans isomerase activity
HM988_RS01930	COG0740	serine-type endopeptidase activity
HM988_RS01935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HM988_RS01965	COG2972	Histidine kinase
HM988_RS01965	COG0745	RESPONSE REGULATOR receiver
HM988_RS01990	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HM988_RS02000	COG0668	transmembrane transport
HM988_RS02005	COG1214	PFAM Peptidase M22, glycoprotease
HM988_RS02020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM988_RS02025	COG0577	efflux transmembrane transporter activity
HM988_RS02025	COG1136	(ABC) transporter
HM988_RS02030	COG1136	(ABC) transporter
HM988_RS02030	COG0577	efflux transmembrane transporter activity
HM988_RS02035	COG1136	(ABC) transporter
HM988_RS02045	COG2322	membrane
HM988_RS02050	COG1999	signal sequence binding
HM988_RS02070	COG1845	cytochrome c oxidase, subunit III
HM988_RS02075	COG0109	protoheme IX farnesyltransferase activity
HM988_RS02120	COG0509	glycine decarboxylation via glycine cleavage system
HM988_RS02130	COG0632	four-way junction helicase activity
HM988_RS02135	COG0281	malic enzyme
HM988_RS02135	COG0280	phosphate acetyltransferase
HM988_RS02150	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HM988_RS02180	COG0745	RESPONSE REGULATOR receiver
HM988_RS02180	COG2205	protein histidine kinase activity
HM988_RS02180	COG3292	Two component regulator propeller
HM988_RS02185	COG2124	cytochrome p450
HM988_RS02190	COG2255	four-way junction helicase activity
HM988_RS02195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HM988_RS02200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HM988_RS02225	COG0437	4 iron, 4 sulfur cluster binding
HM988_RS02245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HM988_RS02250	COG0195	Participates in both transcription termination and antitermination
HM988_RS02255	COG0779	Required for maturation of 30S ribosomal subunits
HM988_RS02280	COG3118	belongs to the thioredoxin family
HM988_RS02290	COG4585	Histidine kinase
HM988_RS02295	COG3279	Response regulator of the LytR AlgR family
HM988_RS02330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HM988_RS02330	COG0189	ligase activity
HM988_RS02335	COG4242	Belongs to the peptidase S51 family
HM988_RS02345	COG2205	protein histidine kinase activity
HM988_RS02345	COG0745	RESPONSE REGULATOR receiver
HM988_RS02345	COG3292	Two component regulator propeller
HM988_RS02365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM988_RS02365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM988_RS02410	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HM988_RS02425	COG1032	radical SAM domain protein
HM988_RS02430	COG0488	(ABC) transporter
HM988_RS02455	COG0009	L-threonylcarbamoyladenylate synthase
HM988_RS02460	COG0589	response to stress
HM988_RS02465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HM988_RS02470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HM988_RS02475	COG0052	Belongs to the universal ribosomal protein uS2 family
HM988_RS02480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HM988_RS02485	COG0528	UMP kinase activity
HM988_RS02490	COG0233	cytoplasmic translational termination
HM988_RS02505	COG0017	Asparaginyl-tRNA synthetase
HM988_RS02510	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HM988_RS02530	COG0848	biopolymer transport protein
HM988_RS02540	COG0811	peptide transport
HM988_RS02550	COG0252	asparaginase activity
HM988_RS02555	COG0084	hydrolase, TatD family'
HM988_RS02570	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM988_RS02595	COG1309	transcriptional regulator
HM988_RS02610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HM988_RS02615	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HM988_RS02630	COG1278	Cold shock
HM988_RS02640	COG0590	tRNA wobble adenosine to inosine editing
HM988_RS02650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HM988_RS02660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HM988_RS02665	COG4771	TonB-dependent receptor
HM988_RS02710	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HM988_RS02715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HM988_RS02715	COG1328	CTP reductase activity
HM988_RS02720	COG3279	Response regulator of the LytR AlgR family
HM988_RS02725	COG3275	phosphorelay sensor kinase activity
HM988_RS02745	COG2095	MarC family integral membrane protein
HM988_RS02795	COG0793	Belongs to the peptidase S41A family
HM988_RS02815	COG0646	methionine synthase
HM988_RS02815	COG1410	methionine synthase
HM988_RS02825	COG1410	methionine synthase
HM988_RS02825	COG0646	methionine synthase
HM988_RS02830	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HM988_RS02835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM988_RS02840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HM988_RS02850	COG0314	molybdopterin synthase activity
HM988_RS02870	COG0746	molybdenum cofactor guanylyltransferase activity
HM988_RS02875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HM988_RS02875	COG0730	response to heat
HM988_RS02885	COG0303	'Molybdopterin
HM988_RS02900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HM988_RS02905	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HM988_RS02910	COG0193	aminoacyl-tRNA hydrolase activity
HM988_RS02920	COG0196	riboflavin kinase activity
HM988_RS02930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HM988_RS02950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HM988_RS02955	COG2239	Acts as a magnesium transporter
HM988_RS02965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM988_RS02970	COG1233	COG1233 Phytoene dehydrogenase and related
HM988_RS02975	COG2197	response regulator
HM988_RS03010	COG0527	aspartate kinase activity
HM988_RS03020	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HM988_RS03030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HM988_RS03045	COG1652	LysM domain
HM988_RS03055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HM988_RS03065	COG1309	transcriptional regulator
HM988_RS03075	COG1538	Outer membrane efflux protein
HM988_RS03095	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HM988_RS03120	COG0288	reversible hydration of carbon dioxide
HM988_RS03125	COG0659	secondary active sulfate transmembrane transporter activity
HM988_RS03175	COG2304	oxidoreductase activity
HM988_RS03190	COG0714	Associated with various cellular activities
HM988_RS03200	COG4989	oxidoreductase activity
HM988_RS03235	COG1012	belongs to the aldehyde dehydrogenase family
HM988_RS03255	COG2329	Antibiotic biosynthesis monooxygenase
HM988_RS03265	COG4953	penicillin-binding protein 1C
HM988_RS03315	COG0612	Peptidase, M16
HM988_RS03320	COG0612	Peptidase, M16
HM988_RS03325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HM988_RS03330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HM988_RS03340	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HM988_RS03345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HM988_RS03355	COG1053	succinate dehydrogenase
HM988_RS03375	COG0006	proline dipeptidase activity
HM988_RS03380	COG0494	nUDIX hydrolase
HM988_RS03385	COG1061	Type III restriction enzyme res subunit
HM988_RS03390	COG0527	aspartate kinase activity
HM988_RS03415	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HM988_RS03425	COG0316	Belongs to the HesB IscA family
HM988_RS03430	COG0719	Fe-S assembly protein
HM988_RS03445	COG0396	ATPase activity
HM988_RS03450	COG0719	Fe-S assembly protein
HM988_RS03475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HM988_RS03485	COG2166	iron-sulfur cluster assembly
HM988_RS03490	COG2151	metal-sulfur cluster biosynthetic enzyme
HM988_RS03525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HM988_RS03550	COG2954	triphosphatase activity
HM988_RS03555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HM988_RS03565	COG0469	pyruvate kinase activity
HM988_RS03575	COG0571	ribonuclease III activity
HM988_RS03580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM988_RS03585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM988_RS03595	COG0328	RNA-DNA hybrid ribonuclease activity
HM988_RS03595	COG3341	Caulimovirus viroplasmin
HM988_RS03630	COG1074	ATP-dependent DNA helicase activity
HM988_RS03635	COG0156	8-amino-7-oxononanoate synthase activity
HM988_RS03655	COG0784	Response regulator, receiver
HM988_RS03655	COG2205	protein histidine kinase activity
HM988_RS03690	COG0720	synthase
HM988_RS03695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM988_RS03715	COG3047	cAMP biosynthetic process
HM988_RS03715	COG2885	chlorophyll binding
HM988_RS03720	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HM988_RS03720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HM988_RS03755	COG4771	TonB-dependent receptor
HM988_RS03755	COG4771	TonB-dependent receptor
HM988_RS03760	COG4206	TonB-dependent receptor
HM988_RS03760	COG1629	transport
HM988_RS03765	COG1573	uracil-dna glycosylase
HM988_RS03780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HM988_RS03800	COG1435	thymidine kinase activity
HM988_RS03805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HM988_RS03810	COG1970	mechanosensitive ion channel activity
HM988_RS03815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HM988_RS03820	COG1505	serine-type exopeptidase activity
HM988_RS03840	COG3842	ATPase activity
HM988_RS03885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM988_RS03900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM988_RS03905	COG3424	synthase
HM988_RS03915	COG1233	COG1233 Phytoene dehydrogenase and related
HM988_RS03930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HM988_RS03935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HM988_RS03935	COG2022	thiamine diphosphate biosynthetic process
HM988_RS03945	COG0439	Biotin carboxylase
HM988_RS03950	COG0511	ligase activity, forming carbon-carbon bonds
HM988_RS03955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM988_RS03960	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HM988_RS03970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HM988_RS03995	COG3206	protein involved in exopolysaccharide biosynthesis
HM988_RS03995	COG0489	protein tyrosine kinase activity
HM988_RS04005	COG1215	transferase activity, transferring glycosyl groups
HM988_RS04025	COG1216	Glycosyl transferase, family 2
HM988_RS04045	COG2089	acid synthase
HM988_RS04075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM988_RS04080	COG1086	Polysaccharide biosynthesis protein
HM988_RS04085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM988_RS04130	COG0346	lactoylglutathione lyase activity
HM988_RS04135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HM988_RS04145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HM988_RS04160	COG2234	aminopeptidase activity
HM988_RS04175	COG0481	GTPase activity
HM988_RS04180	COG3263	regulation of cellular component size
HM988_RS04190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HM988_RS04210	COG0594	ribonuclease P activity
HM988_RS04215	COG0793	Belongs to the peptidase S41A family
HM988_RS04225	COG2153	protein acetylation
HM988_RS04235	COG0698	ribose 5-phosphate isomerase
HM988_RS04245	COG0557	exoribonuclease II activity
HM988_RS04250	COG0393	Putative heavy-metal-binding
HM988_RS04285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HM988_RS04315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HM988_RS04325	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HM988_RS04330	COG0445	tRNA wobble uridine modification
HM988_RS04350	COG0470	DNA polymerase III
HM988_RS04355	COG0126	phosphoglycerate kinase activity
HM988_RS04360	COG1388	LysM domain
HM988_RS04360	COG0791	NLP P60 protein
HM988_RS04370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HM988_RS04405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HM988_RS04410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HM988_RS04420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HM988_RS04470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM988_RS04480	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HM988_RS04500	COG1215	transferase activity, transferring glycosyl groups
HM988_RS04505	COG0151	Belongs to the GarS family
HM988_RS04520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HM988_RS04530	COG0859	PFAM glycosyl transferase family 9
HM988_RS04535	COG0633	Ferredoxin
HM988_RS04580	COG0356	it plays a direct role in the translocation of protons across the membrane
HM988_RS04585	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HM988_RS04590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HM988_RS04595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HM988_RS04600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HM988_RS04610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HM988_RS04635	COG0756	dUTP diphosphatase activity
HM988_RS04640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HM988_RS04665	COG1607	acyl-coa hydrolase
HM988_RS04675	COG0758	DNA mediated transformation
HM988_RS04675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HM988_RS04705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HM988_RS04715	COG1196	nuclear chromosome segregation
HM988_RS04715	COG0741	lytic transglycosylase activity
HM988_RS04715	COG0739	heme binding
HM988_RS04720	COG1774	PSP1 C-terminal conserved region
HM988_RS04730	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HM988_RS04735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HM988_RS04760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HM988_RS04765	COG1253	flavin adenine dinucleotide binding
HM988_RS04770	COG1522	sequence-specific DNA binding
HM988_RS04775	COG0113	porphobilinogen synthase activity
HM988_RS04785	COG0408	coproporphyrinogen oxidase activity
HM988_RS04800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HM988_RS04805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HM988_RS04815	COG0181	hydroxymethylbilane synthase activity
HM988_RS04820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HM988_RS04845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HM988_RS04860	COG5000	phosphorelay sensor kinase activity
HM988_RS04865	COG1024	Enoyl-CoA hydratase
HM988_RS04870	COG3177	Filamentation induced by cAMP protein fic
HM988_RS04890	COG2207	Transcriptional regulator
HM988_RS04900	COG1418	mRNA catabolic process
HM988_RS04925	COG0484	heat shock protein binding
HM988_RS04940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HM988_RS04945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HM988_RS04960	COG1121	(ABC) transporter
HM988_RS04965	COG0803	Belongs to the bacterial solute-binding protein 9 family
HM988_RS04995	COG1999	signal sequence binding
HM988_RS05060	COG1204	response to ionizing radiation
HM988_RS05075	COG2003	Belongs to the UPF0758 family
HM988_RS05145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM988_RS05165	COG0517	IMP dehydrogenase activity
HM988_RS05165	COG0516	GMP reductase activity
HM988_RS05175	COG0629	single-stranded DNA binding
HM988_RS05235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM988_RS05250	COG1473	amidohydrolase
HM988_RS05260	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HM988_RS05265	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HM988_RS05270	COG2080	2 iron, 2 sulfur cluster binding
HM988_RS05350	COG1528	Iron-storage protein
HM988_RS05390	COG1595	DNA-templated transcription, initiation
HM988_RS05395	COG3712	iron ion homeostasis
HM988_RS05405	COG0123	including yeast histone deacetylase and acetoin utilization protein
HM988_RS05415	COG2183	response to ionizing radiation
HM988_RS05440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM988_RS05440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM988_RS05445	COG1619	proteins homologs of microcin C7 resistance protein MccF
HM988_RS05455	COG0792	nuclease activity
HM988_RS05465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HM988_RS05470	COG0194	GDP metabolic process
HM988_RS05475	COG1561	YicC-like family, N-terminal region
HM988_RS05490	COG0697	spore germination
HM988_RS05515	COG0626	cystathionine gamma-synthase activity
HM988_RS05525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM988_RS05535	COG1381	Involved in DNA repair and RecF pathway recombination
HM988_RS05570	COG2268	Band 7 protein
HM988_RS05595	COG3655	Transcriptional regulator
HM988_RS05605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HM988_RS05620	COG1752	Esterase of the alpha-beta hydrolase superfamily
HM988_RS05625	COG0322	excinuclease ABC activity
HM988_RS05630	COG0189	ligase activity
HM988_RS05630	COG4067	protein conserved in archaea
HM988_RS05635	COG0189	ligase activity
HM988_RS05645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HM988_RS05650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HM988_RS05660	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HM988_RS05685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HM988_RS05695	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HM988_RS05720	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HM988_RS05725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HM988_RS05730	COG0297	glycogen (starch) synthase activity
HM988_RS05740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HM988_RS05745	COG4771	TonB-dependent receptor
HM988_RS05770	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HM988_RS05780	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HM988_RS05790	COG3483	tryptophan 2,3-dioxygenase activity
HM988_RS05800	COG0166	Belongs to the GPI family
HM988_RS05805	COG4771	TonB-dependent receptor
HM988_RS05825	COG0629	single-stranded DNA binding
HM988_RS05830	COG1194	a g-specific adenine glycosylase
HM988_RS05835	COG0776	regulation of translation
HM988_RS05840	COG1530	ribonuclease E activity
HM988_RS05860	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HM988_RS05870	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HM988_RS05910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM988_RS05925	COG2827	Endonuclease containing a URI domain
HM988_RS05930	COG3852	Histidine kinase
HM988_RS05935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HM988_RS05945	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HM988_RS05950	COG0519	Catalyzes the synthesis of GMP from XMP
HM988_RS05965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HM988_RS05970	COG1968	undecaprenyl-diphosphatase activity
HM988_RS05980	COG2177	Part of the ABC transporter FtsEX involved in
HM988_RS05985	COG0495	leucyl-tRNA aminoacylation
HM988_RS06015	COG4717	serine-type aminopeptidase activity
HM988_RS06020	COG0436	Aminotransferase
HM988_RS06035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HM988_RS06045	COG1040	competence protein
HM988_RS06055	COG0423	glycine-tRNA ligase activity
HM988_RS06070	COG2072	flavoprotein involved in K transport
HM988_RS06080	COG0708	Exodeoxyribonuclease III
HM988_RS06085	COG1360	Flagellar Motor Protein
HM988_RS06090	COG0667	Aldo Keto reductase
HM988_RS06100	COG1522	sequence-specific DNA binding
HM988_RS06115	COG2363	Small membrane protein
HM988_RS06120	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HM988_RS06135	COG0463	Glycosyl transferase, family 2
HM988_RS06140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM988_RS06155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HM988_RS06180	COG0745	RESPONSE REGULATOR receiver
HM988_RS06185	COG5002	protein histidine kinase activity
HM988_RS06190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HM988_RS06195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HM988_RS06210	COG0489	protein tyrosine kinase activity
HM988_RS06215	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HM988_RS06220	COG0492	ferredoxin-NADP+ reductase activity
HM988_RS06225	COG0633	Ferredoxin
HM988_RS06245	COG0628	permease
HM988_RS06250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HM988_RS06255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HM988_RS06260	COG0228	four-way junction DNA binding
HM988_RS06315	COG4974	Belongs to the 'phage' integrase family
HM988_RS06345	COG0347	Belongs to the P(II) protein family
HM988_RS06380	COG3781	membrane
HM988_RS06395	COG0531	amino acid
HM988_RS06420	COG2217	Heavy metal translocating P-type atpase
HM988_RS06460	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM988_RS06560	COG0629	single-stranded DNA binding
HM988_RS06585	COG1475	DNA binding
HM988_RS06600	COG2839	Protein conserved in bacteria
HM988_RS06640	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HM988_RS06655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HM988_RS06675	COG2315	Protein conserved in bacteria
HM988_RS06680	COG2824	Alkylphosphonate utilization operon protein PhnA
HM988_RS06725	COG2188	Transcriptional regulator
HM988_RS06730	COG1070	Carbohydrate kinase
HM988_RS06735	COG2115	Belongs to the xylose isomerase family
HM988_RS06740	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HM988_RS06745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HM988_RS06750	COG2192	nodulation
HM988_RS06760	COG1028	Short-chain dehydrogenase reductase Sdr
HM988_RS06765	COG1312	Catalyzes the dehydration of D-mannonate
HM988_RS06770	COG1312	Catalyzes the dehydration of D-mannonate
HM988_RS06775	COG1904	glucuronate isomerase
HM988_RS06790	COG1069	ribulokinase activity
HM988_RS06800	COG2160	L-arabinose isomerase activity
HM988_RS06810	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM988_RS06825	COG3507	Belongs to the glycosyl hydrolase 43 family
HM988_RS06830	COG1472	Belongs to the glycosyl hydrolase 3 family
HM988_RS06835	COG3507	Belongs to the glycosyl hydrolase 43 family
HM988_RS06860	COG0667	Aldo Keto reductase
HM988_RS06880	COG5520	Belongs to the glycosyl hydrolase 30 family
HM988_RS06895	COG0702	epimerase
HM988_RS06900	COG4771	TonB-dependent receptor
HM988_RS06910	COG2211	Major facilitator Superfamily
HM988_RS06925	COG3661	Belongs to the glycosyl hydrolase 67 family
HM988_RS06930	COG1472	Belongs to the glycosyl hydrolase 3 family
HM988_RS06945	COG1609	Transcriptional regulator
HM988_RS06950	COG1331	Highly conserved protein containing a thioredoxin domain
HM988_RS06965	COG3386	PFAM SMP-30 Gluconolaconase
HM988_RS06975	COG0366	Alpha amylase catalytic
HM988_RS06990	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HM988_RS06995	COG4206	TonB-dependent receptor
HM988_RS06995	COG1629	transport
HM988_RS07010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HM988_RS07015	COG1554	hydrolase, family 65, central catalytic
HM988_RS07020	COG0366	Alpha amylase catalytic
HM988_RS07025	COG1501	Belongs to the glycosyl hydrolase 31 family
HM988_RS07030	COG1523	belongs to the glycosyl hydrolase 13 family
HM988_RS07040	COG0366	Alpha amylase catalytic
HM988_RS07045	COG1082	Xylose isomerase domain protein TIM barrel
HM988_RS07065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HM988_RS07085	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM988_RS07105	COG2081	HI0933 family
HM988_RS07110	COG2205	protein histidine kinase activity
HM988_RS07110	COG0784	Response regulator, receiver
HM988_RS07150	COG1187	pseudouridine synthase activity
HM988_RS07165	COG3547	Transposase (IS116 IS110 IS902 family)
HM988_RS07180	COG1166	arginine decarboxylase activity
HM988_RS07185	COG0010	Belongs to the arginase family
HM988_RS07190	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HM988_RS07195	COG3153	acetyltransferase
HM988_RS07195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HM988_RS07220	COG1215	transferase activity, transferring glycosyl groups
HM988_RS07225	COG0463	Glycosyl transferase, family 2
HM988_RS07235	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HM988_RS07260	COG0463	Glycosyl transferase, family 2
HM988_RS07275	COG2226	methyltransferase
HM988_RS07280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HM988_RS07305	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HM988_RS07305	COG3608	succinylglutamate desuccinylase aspartoacylase
HM988_RS07320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HM988_RS07335	COG0590	tRNA wobble adenosine to inosine editing
HM988_RS07355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HM988_RS07370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HM988_RS07375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HM988_RS07380	COG0066	3-isopropylmalate dehydratase activity
HM988_RS07390	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HM988_RS07395	COG0004	ammonium transporteR
HM988_RS07400	COG0347	Belongs to the P(II) protein family
HM988_RS07405	COG0004	ammonium transporteR
HM988_RS07415	COG0067	glutamate synthase
HM988_RS07415	COG0070	glutamate synthase
HM988_RS07415	COG0069	glutamate synthase activity
HM988_RS07425	COG0140	phosphoribosyl-ATP diphosphatase activity
HM988_RS07425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HM988_RS07430	COG0107	imidazoleglycerol-phosphate synthase activity
HM988_RS07435	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HM988_RS07440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HM988_RS07445	COG0131	Imidazoleglycerol-phosphate dehydratase
HM988_RS07450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HM988_RS07455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HM988_RS07460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HM988_RS07465	COG0165	Argininosuccinate lyase
HM988_RS07475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HM988_RS07480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HM988_RS07485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM988_RS07495	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HM988_RS07500	COG0137	argininosuccinate synthase activity
HM988_RS07510	COG1012	belongs to the aldehyde dehydrogenase family
HM988_RS07515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HM988_RS07520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HM988_RS07530	COG0028	Belongs to the TPP enzyme family
HM988_RS07535	COG0129	dihydroxy-acid dehydratase activity
HM988_RS07540	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM988_RS07550	COG4771	TonB-dependent receptor
HM988_RS07555	COG0702	epimerase
HM988_RS07590	COG3250	beta-galactosidase activity
HM988_RS07600	COG3119	arylsulfatase activity
HM988_RS07615	COG0477	Major facilitator Superfamily
HM988_RS07615	COG2814	Major facilitator Superfamily
HM988_RS07670	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HM988_RS07710	COG2827	Endonuclease containing a URI domain
HM988_RS07725	COG3104	oligopeptide transport
HM988_RS07730	COG3104	oligopeptide transport
HM988_RS07740	COG2333	competence protein COMEC
HM988_RS07740	COG0658	competence protein
HM988_RS07745	COG0791	NLP P60 protein
HM988_RS07750	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM988_RS07755	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HM988_RS07760	COG0793	Belongs to the peptidase S41A family
HM988_RS07765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HM988_RS07770	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HM988_RS07775	COG2267	carboxylic ester hydrolase activity
HM988_RS07780	COG2001	Belongs to the MraZ family
HM988_RS07785	COG0275	rRNA processing
HM988_RS07800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HM988_RS07805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM988_RS07815	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HM988_RS07820	COG0772	Belongs to the SEDS family
HM988_RS07825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HM988_RS07830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HM988_RS07845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HM988_RS07850	COG1610	YqeY-like protein
HM988_RS07870	COG1289	transmembrane transporter activity
HM988_RS07875	COG0069	glutamate synthase activity
HM988_RS07925	COG0529	Catalyzes the synthesis of activated sulfate
HM988_RS07930	COG0175	sulfate reduction
HM988_RS07945	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HM988_RS07950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM988_RS07965	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HM988_RS08010	COG2030	dehydratase
HM988_RS08020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM988_RS08035	COG0438	transferase activity, transferring glycosyl groups
HM988_RS08040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HM988_RS08045	COG0463	Glycosyl transferase, family 2
HM988_RS08085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM988_RS08090	COG0110	maltose O-acetyltransferase activity
HM988_RS08100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM988_RS08115	COG0517	IMP dehydrogenase activity
HM988_RS08120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HM988_RS08125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HM988_RS08135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HM988_RS08140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HM988_RS08145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HM988_RS08150	COG1215	transferase activity, transferring glycosyl groups
HM988_RS08195	COG1185	polyribonucleotide nucleotidyltransferase activity
HM988_RS08200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HM988_RS08205	COG3290	protein histidine kinase activity
HM988_RS08210	COG2205	protein histidine kinase activity
HM988_RS08220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HM988_RS08225	COG0191	fructose-bisphosphate aldolase activity
HM988_RS08235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM988_RS08245	COG2226	methyltransferase
HM988_RS08250	COG0569	domain protein
HM988_RS08270	COG0436	Aminotransferase
HM988_RS08275	COG3239	Fatty acid desaturase
HM988_RS08280	COG0357	Ribosomal RNA small subunit methyltransferase G
HM988_RS08295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM988_RS08310	COG1012	belongs to the aldehyde dehydrogenase family
HM988_RS08320	COG2967	ApaG domain
HM988_RS08325	COG0076	glutamate decarboxylase activity
HM988_RS08340	COG1805	sodium ion transport
HM988_RS08345	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HM988_RS08380	COG2311	Membrane
HM988_RS08385	COG2311	Membrane
HM988_RS08390	COG2267	carboxylic ester hydrolase activity
HM988_RS08440	COG1477	protein flavinylation
HM988_RS08450	COG2226	methyltransferase
HM988_RS08470	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HM988_RS08485	COG3340	Belongs to the peptidase S51 family
HM988_RS08515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HM988_RS08540	COG1028	Short-chain dehydrogenase reductase Sdr
HM988_RS08560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HM988_RS08565	COG3844	kynureninase activity
HM988_RS08595	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HM988_RS08600	COG1663	tetraacyldisaccharide 4'-kinase activity
HM988_RS08605	COG2205	protein histidine kinase activity
HM988_RS08605	COG0784	Response regulator, receiver
HM988_RS08610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HM988_RS08615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HM988_RS08645	COG1595	DNA-templated transcription, initiation
HM988_RS08650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HM988_RS08655	COG0436	Aminotransferase
HM988_RS08665	COG0525	valine-tRNA ligase activity
HM988_RS08670	COG0772	Belongs to the SEDS family
HM988_RS08675	COG0768	penicillin binding
HM988_RS08690	COG1077	Cell shape determining protein MreB Mrl
HM988_RS08695	COG0138	bifunctional purine biosynthesis protein purh
HM988_RS08705	COG2373	Large extracellular alpha-helical protein
HM988_RS08730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HM988_RS08735	COG3002	Belongs to the UPF0753 family
HM988_RS08745	COG2274	protein secretion by the type I secretion system
HM988_RS08760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HM988_RS08765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM988_RS08800	COG2003	Belongs to the UPF0758 family
HM988_RS08810	COG1011	Hydrolase
HM988_RS08820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HM988_RS08830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM988_RS08840	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HM988_RS08845	COG0049	tRNA binding
HM988_RS08850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HM988_RS08855	COG0051	transcription antitermination factor activity, RNA binding
HM988_RS08860	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HM988_RS08865	COG0088	Forms part of the polypeptide exit tunnel
HM988_RS08870	COG0089	rRNA binding
HM988_RS08875	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HM988_RS08880	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HM988_RS08885	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HM988_RS08890	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HM988_RS08895	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HM988_RS08900	COG0255	Belongs to the universal ribosomal protein uL29 family
HM988_RS08905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HM988_RS08910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HM988_RS08915	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HM988_RS08920	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HM988_RS08925	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HM988_RS08930	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HM988_RS08935	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HM988_RS08940	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HM988_RS08945	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HM988_RS08950	COG1841	ribosomal large subunit assembly
HM988_RS08955	COG0200	Binds to the 23S rRNA
HM988_RS08960	COG0201	protein transport
HM988_RS08965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HM988_RS08970	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HM988_RS08975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HM988_RS08980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HM988_RS08985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HM988_RS08990	COG0202	RNA polymerase activity
HM988_RS08995	COG0203	ribosomal protein L17
HM988_RS09005	COG0148	phosphopyruvate hydratase activity
HM988_RS09035	COG0688	phosphatidylethanolamine metabolic process
HM988_RS09040	COG4589	Belongs to the CDS family
HM988_RS09050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HM988_RS09055	COG0799	negative regulation of ribosome biogenesis
HM988_RS09070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HM988_RS09110	COG5002	protein histidine kinase activity
HM988_RS09115	COG4676	Protein conserved in bacteria
HM988_RS09120	COG0018	arginyl-trna synthetase
HM988_RS09135	COG2318	DinB family
HM988_RS09165	COG0433	COG0433 Predicted ATPase
HM988_RS09175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HM988_RS09175	COG0662	Cupin 2, conserved barrel domain protein
HM988_RS09200	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HM988_RS09210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HM988_RS09215	COG0602	queuosine metabolic process
HM988_RS09225	COG0367	asparagine synthase
HM988_RS09230	COG0187	DNA topoisomerase II activity
HM988_RS09235	COG5002	protein histidine kinase activity
HM988_RS09235	COG0784	Response regulator, receiver
HM988_RS09260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HM988_RS09280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HM988_RS09285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HM988_RS09290	COG0215	cysteine-tRNA ligase activity
HM988_RS09295	COG0302	gtp cyclohydrolase
HM988_RS09320	COG0442	prolyl-tRNA aminoacylation
HM988_RS09330	COG0268	Binds directly to 16S ribosomal RNA
HM988_RS09350	COG0673	inositol 2-dehydrogenase activity
HM988_RS09370	COG0784	Response regulator, receiver
HM988_RS09375	COG4251	negative regulation of phosphorylation
HM988_RS09410	COG2356	endonuclease I
HM988_RS09420	COG0174	glutamine synthetase
HM988_RS09440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HM988_RS09450	COG1129	ABC transporter
HM988_RS09460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HM988_RS09465	COG0681	Belongs to the peptidase S26 family
HM988_RS09470	COG0284	orotidine-5'-phosphate decarboxylase activity
HM988_RS09475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HM988_RS09490	COG0788	formyltetrahydrofolate deformylase activity
HM988_RS09495	COG1703	isobutyryl-CoA mutase activity
HM988_RS09495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM988_RS09495	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM988_RS09515	COG1522	sequence-specific DNA binding
HM988_RS09525	COG0492	ferredoxin-NADP+ reductase activity
HM988_RS09535	COG2814	Major facilitator Superfamily
HM988_RS09550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HM988_RS09580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HM988_RS09590	COG0463	Glycosyl transferase, family 2
HM988_RS09605	COG2244	polysaccharide biosynthetic process
HM988_RS09625	COG0438	transferase activity, transferring glycosyl groups
HM988_RS09635	COG1216	Glycosyl transferase, family 2
HM988_RS09635	COG1442	glycosyl transferase family 8
HM988_RS09655	COG2884	Cell division ATP-binding protein ftsE
HM988_RS09660	COG0133	tryptophan synthase activity
HM988_RS09665	COG0135	phosphoribosylanthranilate isomerase activity
HM988_RS09670	COG0134	indole-3-glycerol-phosphate synthase activity
HM988_RS09675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HM988_RS09680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HM988_RS09680	COG0512	Glutamine amidotransferase of anthranilate synthase
HM988_RS09685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HM988_RS09695	COG1846	Transcriptional regulator
HM988_RS09710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HM988_RS09730	COG3852	Histidine kinase
HM988_RS09755	COG0577	efflux transmembrane transporter activity
HM988_RS09755	COG1136	(ABC) transporter
HM988_RS09760	COG0577	efflux transmembrane transporter activity
HM988_RS09770	COG0577	efflux transmembrane transporter activity
HM988_RS09785	COG1136	(ABC) transporter
HM988_RS09815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM988_RS09820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM988_RS09825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM988_RS09865	COG1047	Peptidyl-prolyl cis-trans
HM988_RS09875	COG1349	DNA-binding transcription factor activity
HM988_RS09880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HM988_RS09885	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HM988_RS09890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HM988_RS09900	COG4771	TonB-dependent receptor
HM988_RS09925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HM988_RS09940	COG2885	chlorophyll binding
HM988_RS09940	COG3047	cAMP biosynthetic process
HM988_RS09945	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HM988_RS09955	COG1482	cell wall glycoprotein biosynthetic process
HM988_RS09990	COG1073	alpha beta
HM988_RS10015	COG1595	DNA-templated transcription, initiation
HM988_RS10030	COG0513	Belongs to the DEAD box helicase family
HM988_RS10035	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HM988_RS10055	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HM988_RS10075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM988_RS10085	COG4771	TonB-dependent receptor
HM988_RS10090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM988_RS10100	COG0326	Molecular chaperone. Has ATPase activity
HM988_RS10110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM988_RS10245	COG3609	addiction module antidote protein, CC2985 family
HM988_RS10270	COG2732	(Barnase) inhibitor
HM988_RS10290	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM988_RS10310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HM988_RS10335	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM988_RS10340	COG1902	pentaerythritol trinitrate reductase activity
HM988_RS10345	COG0450	alkyl hydroperoxide reductase
HM988_RS10365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HM988_RS10370	COG0179	Fumarylacetoacetate (FAA) hydrolase
HM988_RS10380	COG1058	Belongs to the CinA family
HM988_RS10380	COG1546	Belongs to the CinA family
HM988_RS10385	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HM988_RS10390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HM988_RS10400	COG0552	protein localization to endoplasmic reticulum
HM988_RS10405	COG0154	amidase activity
HM988_RS10425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM988_RS10440	COG0656	L-ascorbic acid biosynthetic process
HM988_RS10495	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HM988_RS10535	COG0519	Catalyzes the synthesis of GMP from XMP
HM988_RS10535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HM988_RS10555	COG0504	CTP synthase activity
HM988_RS10560	COG0706	membrane insertase activity
HM988_RS10565	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM988_RS10575	COG0482	sulfurtransferase activity
HM988_RS10620	COG0534	Mate efflux family protein
HM988_RS10630	COG0671	phosphoesterase, PA-phosphatase related
HM988_RS10635	COG0671	phosphoesterase, PA-phosphatase related
HM988_RS10645	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM988_RS10645	COG3952	Lipid A Biosynthesis
HM988_RS10650	COG0463	Glycosyl transferase, family 2
HM988_RS10665	COG1595	DNA-templated transcription, initiation
HM988_RS10680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM988_RS10740	COG2827	Endonuclease containing a URI domain
HM988_RS10745	COG0653	protein targeting
HM988_RS10760	COG1136	(ABC) transporter
HM988_RS10770	COG0488	(ABC) transporter
HM988_RS10780	COG0489	protein tyrosine kinase activity
HM988_RS10780	COG3206	protein involved in exopolysaccharide biosynthesis
HM988_RS10785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM988_RS10790	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HM988_RS10835	COG2089	acid synthase
HM988_RS10845	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HM988_RS10850	COG1083	cytidylyl-transferase
HM988_RS10910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM988_RS10925	COG1183	phosphatidylcholine synthase activity
HM988_RS10930	COG2354	Protein conserved in bacteria
HM988_RS10935	COG1137	ATPase activity
HM988_RS10940	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HM988_RS10945	COG0805	protein transport
HM988_RS10950	COG0517	IMP dehydrogenase activity
HM988_RS10950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HM988_RS10955	COG0514	ATP-dependent DNA helicase (RecQ)
HM988_RS10965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM988_RS11020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HM988_RS11030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HM988_RS11040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HM988_RS11070	COG0681	Belongs to the peptidase S26 family
HM988_RS11075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HM988_RS11085	COG1475	DNA binding
HM988_RS11090	COG1192	Involved in chromosome partitioning
HM988_RS11095	COG1028	Short-chain dehydrogenase reductase Sdr
HM988_RS11105	COG4946	Tricorn protease homolog
HM988_RS11105	COG0823	Involved in the tonB-independent uptake of proteins
HM988_RS11105	COG1506	peptidase
HM988_RS11110	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM988_RS11110	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM988_RS11120	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM988_RS11130	COG0572	uridine kinase
HM988_RS11135	COG2010	Cytochrome c
HM988_RS11155	COG1917	Cupin 2, conserved barrel domain protein
HM988_RS11155	COG2169	Transcriptional regulator
HM988_RS11160	COG0656	L-ascorbic acid biosynthetic process
HM988_RS11165	COG0667	Aldo Keto reductase
HM988_RS11170	COG0667	Aldo Keto reductase
HM988_RS11175	COG0716	FMN binding
HM988_RS11190	COG1073	alpha beta
HM988_RS11225	COG5002	protein histidine kinase activity
HM988_RS11275	COG1012	belongs to the aldehyde dehydrogenase family
HM988_RS11410	COG0783	Belongs to the Dps family
HM988_RS11425	COG0714	Associated with various cellular activities
HM988_RS11495	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HM988_RS11560	COG3275	phosphorelay sensor kinase activity
HM988_RS11580	COG3279	Response regulator of the LytR AlgR family
HM988_RS11595	COG1595	DNA-templated transcription, initiation
HM988_RS11600	COG3591	Belongs to the peptidase S1B family
HM988_RS11635	COG0598	Magnesium transport protein CorA
HM988_RS11650	COG0424	maF-like protein
HM988_RS11690	COG1970	mechanosensitive ion channel activity
HM988_RS11695	COG1333	cytochrome c biogenesis protein
HM988_RS11695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HM988_RS11705	COG0626	cystathionine gamma-synthase activity
HM988_RS11715	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HM988_RS11720	COG0490	domain, Protein
HM988_RS11720	COG0471	metal ion transport
HM988_RS11725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HM988_RS11735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM988_RS11745	COG1132	(ABC) transporter
HM988_RS11750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM988_RS11755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HM988_RS11765	COG1862	Preprotein translocase
HM988_RS11770	COG4206	TonB-dependent receptor
HM988_RS11770	COG1629	transport
HM988_RS11775	COG3011	Protein conserved in bacteria
HM988_RS11785	COG1288	antiporter activity
HM988_RS11790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HM988_RS11800	COG0813	purine-nucleoside phosphorylase activity
HM988_RS11820	COG0022	dehydrogenase e1 component
HM988_RS11825	COG0071	Belongs to the small heat shock protein (HSP20) family
HM988_RS11845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HM988_RS11855	COG2195	Cleaves the N-terminal amino acid of tripeptides
HM988_RS11860	COG0589	response to stress
HM988_RS11865	COG0167	dihydroorotate dehydrogenase activity
HM988_RS11910	COG0516	GMP reductase activity
HM988_RS11910	COG0517	IMP dehydrogenase activity
HM988_RS11930	COG0693	protein deglycase activity
HM988_RS11935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HM988_RS11970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HM988_RS11985	COG0714	Associated with various cellular activities
HM988_RS12005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HM988_RS12020	COG0742	ribosomal rna small subunit methyltransferase
HM988_RS12035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM988_RS12050	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HM988_RS12065	COG1454	alcohol dehydrogenase
HM988_RS12085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HM988_RS12100	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HM988_RS12110	COG1295	ribonuclease BN
HM988_RS12115	COG3279	Response regulator of the LytR AlgR family
HM988_RS12120	COG3275	phosphorelay sensor kinase activity
HM988_RS12155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HM988_RS12160	COG3279	Response regulator of the LytR AlgR family
HM988_RS12165	COG0360	Binds together with S18 to 16S ribosomal RNA
HM988_RS12170	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HM988_RS12175	COG0359	binds to the 23S rRNA
HM988_RS12180	COG0584	glycerophosphoryl diester phosphodiesterase
HM988_RS12195	COG0577	efflux transmembrane transporter activity
HM988_RS12195	COG1136	(ABC) transporter
HM988_RS12200	COG0124	histidyl-tRNA synthetase
HM988_RS12205	COG4409	exo-alpha-(2->6)-sialidase activity
HM988_RS12225	COG0471	metal ion transport
HM988_RS12250	COG0732	type I restriction modification DNA specificity domain
HM988_RS12295	COG0367	asparagine synthase
HM988_RS12315	COG1858	cytochrome C peroxidase
HM988_RS12390	COG1678	Uncharacterized ACR, COG1678
HM988_RS12400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM988_RS12405	COG0514	ATP-dependent DNA helicase (RecQ)
HM988_RS12425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HM988_RS12440	COG0415	Belongs to the DNA photolyase family
HM988_RS12460	COG0386	Belongs to the glutathione peroxidase family
HM988_RS12465	COG0300	oxidoreductase activity
HM988_RS12475	COG0302	gtp cyclohydrolase
HM988_RS12490	COG0415	Belongs to the DNA photolyase family
HM988_RS12495	COG3046	protein related to deoxyribodipyrimidine photolyase
HM988_RS12500	COG0415	Belongs to the DNA photolyase family
HM988_RS12510	COG0702	epimerase
HM988_RS12535	COG0673	inositol 2-dehydrogenase activity
HM988_RS12565	COG0673	inositol 2-dehydrogenase activity
HM988_RS12580	COG3177	Filamentation induced by cAMP protein fic
HM988_RS12685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM988_RS12720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HM988_RS12725	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HM988_RS12735	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HM988_RS12750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HM988_RS12755	COG3959	Transketolase, thiamine diphosphate binding domain
HM988_RS12760	COG0343	queuine tRNA-ribosyltransferase activity
HM988_RS12775	COG0825	malonyl-CoA metabolic process
HM988_RS12780	COG0305	Participates in initiation and elongation during chromosome replication
HM988_RS12820	COG0561	phosphatase activity
HM988_RS12825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HM988_RS12830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HM988_RS12835	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HM988_RS12840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HM988_RS12870	COG0564	pseudouridine synthase activity
HM988_RS12875	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HM988_RS12880	COG1760	l-serine dehydratase
HM988_RS12895	COG0443	Heat shock 70 kDa protein
HM988_RS12900	COG2986	histidine ammonia-lyase
HM988_RS12955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HM988_RS12960	COG1388	LysM domain
HM988_RS12960	COG0791	NLP P60 protein
HM988_RS12970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HM988_RS12990	COG0540	Belongs to the ATCase OTCase family
HM988_RS13000	COG1234	tRNA 3'-trailer cleavage
HM988_RS13005	COG0259	pyridoxamine-phosphate oxidase activity
HM988_RS13030	COG2885	chlorophyll binding
HM988_RS13050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HM988_RS13065	COG2234	aminopeptidase activity
HM988_RS13105	COG2217	Heavy metal translocating P-type atpase
HM988_RS13125	COG1366	Belongs to the anti-sigma-factor antagonist family
HM988_RS13125	COG2202	Pas domain
HM988_RS13150	COG0589	response to stress
HM988_RS13170	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HM988_RS13185	COG0589	response to stress
HM988_RS13205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HM988_RS13215	COG2885	chlorophyll binding
HM988_RS13240	COG0335	large ribosomal subunit rRNA binding
HM988_RS13245	COG0336	Belongs to the RNA methyltransferase TrmD family
HM988_RS13250	COG0095	Lipoate-protein ligase
HM988_RS13255	COG0596	Alpha beta hydrolase
HM988_RS13270	COG0339	signal peptide processing
HM988_RS13275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM988_RS13280	COG0494	nUDIX hydrolase
HM988_RS13300	COG1252	NADH dehydrogenase
HM988_RS13315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HM988_RS13325	COG0798	PFAM Bile acid sodium symporter
HM988_RS13355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HM988_RS13365	COG0083	homoserine kinase activity
HM988_RS13370	COG0460	homoserine dehydrogenase
HM988_RS13370	COG0527	aspartate kinase activity
HM988_RS13375	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HM988_RS13380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM988_RS13385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HM988_RS13390	COG2070	2-Nitropropane dioxygenase
HM988_RS13450	COG4946	Tricorn protease homolog
HM988_RS13450	COG0793	Belongs to the peptidase S41A family
HM988_RS13455	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HM988_RS13465	COG2996	Protein conserved in bacteria
HM988_RS13480	COG1575	Belongs to the MenA family. Type 1 subfamily
HM988_RS13485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HM988_RS13500	COG4948	Mandelate Racemase Muconate Lactonizing
HM988_RS13515	COG2304	oxidoreductase activity
HM988_RS13530	COG0012	GTP binding
HM988_RS13575	COG0861	Integral membrane protein TerC family
HM988_RS13595	COG1522	sequence-specific DNA binding
HM988_RS13605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HM988_RS13610	COG0506	proline dehydrogenase activity
HM988_RS13630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM988_RS13645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM988_RS13655	COG0367	asparagine synthase
HM988_RS13660	COG0438	transferase activity, transferring glycosyl groups
HM988_RS13675	COG1216	Glycosyl transferase, family 2
HM988_RS13695	COG1216	Glycosyl transferase, family 2
HM988_RS13700	COG5492	domain, Protein
HM988_RS13710	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HM988_RS13740	COG0802	atpase or kinase
HM988_RS13745	COG2204	response regulator
HM988_RS13750	COG1078	dGTPase activity
HM988_RS13755	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM988_RS13760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HM988_RS13760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM988_RS13765	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM988_RS13770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HM988_RS13775	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM988_RS13785	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HM988_RS13790	COG0612	Peptidase, M16
HM988_RS13795	COG1028	Short-chain dehydrogenase reductase Sdr
HM988_RS13820	COG0101	tRNA pseudouridine synthase activity
HM988_RS13835	COG0783	Belongs to the Dps family
HM988_RS13840	COG0668	transmembrane transport
HM988_RS13870	COG0668	transmembrane transport
HM988_RS13875	COG2814	Major facilitator Superfamily
HM988_RS13880	COG1278	Cold shock
HM988_RS13885	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM988_RS13900	COG4942	peptidase
HM988_RS13920	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HM988_RS13925	COG1028	Short-chain dehydrogenase reductase Sdr
HM988_RS13940	COG0513	Belongs to the DEAD box helicase family
HM988_RS13955	COG1278	Cold shock
HM988_RS13980	COG1012	belongs to the aldehyde dehydrogenase family
HM988_RS13985	COG4221	oxidoreductase activity
HM988_RS13995	COG1902	pentaerythritol trinitrate reductase activity
HM988_RS14020	COG0210	DNA helicase
HM988_RS14040	COG4251	negative regulation of phosphorylation
HM988_RS14055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM988_RS14070	COG2135	peptidase activity
HM988_RS14080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM988_RS14085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM988_RS14105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HM988_RS14120	COG1266	CAAX protease self-immunity
HM988_RS14135	COG3275	phosphorelay sensor kinase activity
HM988_RS14150	COG1131	(ABC) transporter
HM988_RS14155	COG3275	phosphorelay sensor kinase activity
HM988_RS14160	COG3279	Response regulator of the LytR AlgR family
HM988_RS14165	COG3250	beta-galactosidase activity
HM988_RS14170	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM988_RS14175	COG0633	Ferredoxin
HM988_RS14175	COG0543	2 iron, 2 sulfur cluster binding
HM988_RS14195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HM988_RS14200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM988_RS14225	COG1960	acyl-CoA dehydrogenase activity
HM988_RS14245	COG2130	NADP-dependent
HM988_RS14280	COG3279	Response regulator of the LytR AlgR family
HM988_RS14285	COG0745	RESPONSE REGULATOR receiver
HM988_RS14285	COG2972	Histidine kinase
HM988_RS14295	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HM988_RS14300	COG2066	Belongs to the glutaminase family
HM988_RS14310	COG2307	Protein conserved in bacteria
HM988_RS14310	COG2308	Evidence 4 Homologs of previously reported genes of
HM988_RS14335	COG2308	Evidence 4 Homologs of previously reported genes of
HM988_RS14345	COG0322	excinuclease ABC activity
HM988_RS14350	COG3237	CsbD-like
HM988_RS14360	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HM988_RS14365	COG4181	ATPase activity
HM988_RS14385	COG0668	transmembrane transport
HM988_RS14390	COG1752	Esterase of the alpha-beta hydrolase superfamily
HM988_RS14445	COG2267	carboxylic ester hydrolase activity
HM988_RS14480	COG1187	pseudouridine synthase activity
HM988_RS14490	COG2897	thiosulfate sulfurtransferase activity
HM988_RS14495	COG1301	dicarboxylic acid transport
HM988_RS14505	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HM988_RS14515	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM988_RS14525	COG0247	lactate metabolic process
HM988_RS14525	COG0277	FAD linked oxidase domain protein
HM988_RS14560	COG3871	stress protein (general stress protein 26)
HM988_RS14575	COG2323	membrane
HM988_RS14580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HM988_RS14590	COG2154	pterin-4-alpha-carbinolamine dehydratase
HM988_RS14595	COG0217	transcriptional regulatory protein
HM988_RS14605	COG4974	Belongs to the 'phage' integrase family
HM988_RS14730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HM988_RS14850	COG1473	amidohydrolase
HM988_RS14890	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HM988_RS14905	COG1674	ftsk spoiiie
HM988_RS14920	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM988_RS14920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM988_RS15005	COG2205	protein histidine kinase activity
HM988_RS15005	COG0745	RESPONSE REGULATOR receiver
HM988_RS15005	COG3292	Two component regulator propeller
HM988_RS15010	COG3292	Two component regulator propeller
HM988_RS15010	COG0745	RESPONSE REGULATOR receiver
HM988_RS15010	COG2205	protein histidine kinase activity
HM988_RS15015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM988_RS15020	COG0778	Nitroreductase
HM988_RS15030	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HM988_RS15050	COG1984	allophanate hydrolase subunit 2
HM988_RS15055	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HM988_RS15060	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HM988_RS15090	COG0606	chelatase, subunit chli
HM988_RS15120	COG0429	hydrolase of the alpha beta-hydrolase fold
HM988_RS15125	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HM988_RS15150	COG0513	Belongs to the DEAD box helicase family
HM988_RS15165	COG1595	DNA-templated transcription, initiation
HM988_RS15180	COG3275	phosphorelay sensor kinase activity
HM988_RS15185	COG3279	Response regulator of the LytR AlgR family
HM988_RS15195	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HM988_RS15200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HM988_RS15215	COG0626	cystathionine gamma-synthase activity
HM988_RS15230	COG0450	alkyl hydroperoxide reductase
HM988_RS15235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM988_RS15245	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HM988_RS15260	COG0488	(ABC) transporter
HM988_RS15270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HM988_RS15280	COG0300	oxidoreductase activity
HM988_RS15315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HM988_RS15325	COG0564	pseudouridine synthase activity
HM988_RS15350	COG0542	response to heat
HM988_RS15360	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HM988_RS15365	COG0813	purine-nucleoside phosphorylase activity
HM988_RS15380	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HM988_RS15400	COG2936	dipeptidyl-peptidase activity
HM988_RS15405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HM988_RS15410	COG0673	inositol 2-dehydrogenase activity
HM988_RS15415	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM988_RS15435	COG2176	DNA-directed DNA polymerase activity
HM988_RS15445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HM988_RS15450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HM988_RS15470	COG0237	dephospho-CoA kinase activity
HM988_RS15495	COG0497	DNA recombination
HM988_RS15520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HM988_RS15535	COG0737	Belongs to the 5'-nucleotidase family
HM988_RS15545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HM988_RS15550	COG2890	protein-(glutamine-N5) methyltransferase activity
HM988_RS15565	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HM988_RS15565	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HM988_RS15570	COG1011	Hydrolase
HM988_RS15575	COG0697	spore germination
HM988_RS15585	COG1739	Uncharacterized protein family UPF0029
HM988_RS15590	COG0824	Thioesterase
HM988_RS15595	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HM988_RS15600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HM988_RS15610	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HM988_RS15625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HM988_RS15635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HM988_RS15640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HM988_RS15755	COG3547	Transposase (IS116 IS110 IS902 family)
HM988_RS15805	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HM988_RS15860	COG2378	regulation of single-species biofilm formation
HM988_RS15870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HM988_RS15880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HM988_RS15885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM988_RS15940	COG2382	esterase
HM988_RS15945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HM988_RS15965	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HM988_RS15980	COG2755	lipolytic protein G-D-S-L family
HM988_RS15995	COG1228	amidohydrolase
HM988_RS16005	COG0010	Belongs to the arginase family
HM988_RS16075	COG0488	(ABC) transporter
HM988_RS16085	COG1741	Belongs to the pirin family
HM988_RS16105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HM988_RS16145	COG0205	6-phosphofructokinase activity
HM988_RS16155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HM988_RS16185	COG0628	permease
HM988_RS16205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HM988_RS16205	COG1793	dna ligase
HM988_RS16235	COG4251	negative regulation of phosphorylation
HM988_RS16240	COG4251	negative regulation of phosphorylation
HM988_RS16245	COG0784	Response regulator, receiver
HM988_RS16255	COG2201	protein-glutamate methylesterase activity
HM988_RS16260	COG1480	7TM receptor with intracellular HD hydrolase
HM988_RS16265	COG0183	Belongs to the thiolase family
HM988_RS16270	COG0791	NLP P60 protein
HM988_RS16275	COG3063	Type IV pilus biogenesis stability protein PilW
HM988_RS16285	COG0542	response to heat
HM988_RS16295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HM988_RS16305	COG0366	Alpha amylase catalytic
HM988_RS16310	COG3387	PFAM Glycoside hydrolase 15-related
HM988_RS16315	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HM988_RS16320	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HM988_RS16325	COG0297	glycogen (starch) synthase activity
HM988_RS16330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM988_RS16350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HM988_RS16360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HM988_RS16395	COG1418	mRNA catabolic process
HM988_RS16430	COG1104	cysteine desulfurase activity
HM988_RS16460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM988_RS16475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HM988_RS16495	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HM988_RS16500	COG1702	phosphate starvation-inducible protein PhoH
HM988_RS16530	COG0592	DNA-directed DNA polymerase activity
HM988_RS16555	COG1294	oxidase, subunit
HM988_RS16560	COG1271	oxidase subunit
HM988_RS16585	COG0471	metal ion transport
HM988_RS16585	COG3273	potassium ion transport
HM988_RS16630	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HM988_RS16650	COG1028	Short-chain dehydrogenase reductase Sdr
HM988_RS16685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM988_RS16700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HM988_RS16705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM988_RS16725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HM988_RS16755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HM988_RS16755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HM988_RS16780	COG1846	Transcriptional regulator
HM988_RS16785	COG1024	Enoyl-CoA hydratase
HM988_RS16785	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM988_RS16790	COG0183	Belongs to the thiolase family
HM988_RS16800	COG1960	acyl-CoA dehydrogenase activity
HM988_RS16805	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM988_RS16835	COG2234	aminopeptidase activity
HM988_RS16840	COG0739	heme binding
HM988_RS16890	COG2217	Heavy metal translocating P-type atpase
HM988_RS16910	COG2010	Cytochrome c
HM988_RS16915	COG0348	domain, Protein
HM988_RS16940	COG0589	response to stress
HM988_RS16945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HM988_RS16950	COG2032	superoxide dismutase activity
HM988_RS16965	COG1272	protein, Hemolysin III
HM988_RS16975	COG1363	Peptidase, m42
HM988_RS16985	COG2339	peptidase activity
HM988_RS16995	COG0439	Biotin carboxylase
HM988_RS17000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HM988_RS17005	COG1132	(ABC) transporter
HM988_RS17015	COG2814	Major facilitator Superfamily
HM988_RS17020	COG0009	L-threonylcarbamoyladenylate synthase
HM988_RS17055	COG0438	transferase activity, transferring glycosyl groups
HM988_RS17060	COG1472	Belongs to the glycosyl hydrolase 3 family
HM988_RS17065	COG3830	Belongs to the UPF0237 family
HM988_RS17065	COG0560	Phosphoserine phosphatase
HM988_RS17085	COG0247	lactate metabolic process
HM988_RS17085	COG2181	nitrate reductase activity
HM988_RS17090	COG2181	nitrate reductase activity
HM988_RS17090	COG0247	lactate metabolic process
HM988_RS17095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HM988_RS17100	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM988_RS17110	COG0251	oxidation-reduction process
HM988_RS17125	COG0516	GMP reductase activity
HM988_RS17150	COG4251	negative regulation of phosphorylation
HM988_RS17160	COG1215	transferase activity, transferring glycosyl groups
HM988_RS17170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM988_RS17215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HM988_RS17220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HM988_RS17235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HM988_RS17300	COG0156	8-amino-7-oxononanoate synthase activity
HM988_RS17315	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HM988_RS17330	COG1393	Belongs to the ArsC family
HM988_RS17350	COG1064	alcohol dehydrogenase
HM988_RS17360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HM988_RS17370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HM988_RS17380	COG1012	belongs to the aldehyde dehydrogenase family
HM988_RS17390	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM988_RS17400	COG1115	amino acid carrier protein
HM988_RS17440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HM988_RS17465	COG1120	ATPase activity
HM988_RS17470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HM988_RS17500	COG4640	response to antibiotic
HM988_RS17545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HM988_RS17550	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HM988_RS17560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HM988_RS17585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM988_RS17590	COG4166	transmembrane transport
HM988_RS17605	COG0254	rRNA binding
HM988_RS17620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HM988_RS17625	COG1132	(ABC) transporter
HM988_RS17630	COG1595	DNA-templated transcription, initiation
HM988_RS17645	COG0179	Fumarylacetoacetate (FAA) hydrolase
HM988_RS17655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HM988_RS17665	COG1611	Belongs to the LOG family
HM988_RS17700	COG0116	Belongs to the methyltransferase superfamily
HM988_RS17700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HM988_RS17705	COG2226	methyltransferase
HM988_RS17775	COG0105	UTP biosynthetic process
HM988_RS17780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HM988_RS17790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM988_RS17795	COG2195	Cleaves the N-terminal amino acid of tripeptides
HM988_RS17830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM988_RS17835	COG0501	Belongs to the peptidase M48B family
HM988_RS17850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HM988_RS17860	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HM988_RS17870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM988_RS17890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HM988_RS17915	COG3956	TIGRFAM MazG family protein
HM988_RS17925	COG0242	peptide deformylase activity
HM988_RS17930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HM988_RS17935	COG3549	Plasmid maintenance system killer
HM988_RS17945	COG2171	N-acyltransferase activity
HM988_RS17965	COG0463	Glycosyl transferase, family 2
HM988_RS17970	COG1215	transferase activity, transferring glycosyl groups
HM988_RS17975	COG0463	Glycosyl transferase, family 2
HM988_RS17980	COG0726	polysaccharide deacetylase
HM988_RS17990	COG0463	Glycosyl transferase, family 2
HM988_RS18010	COG0367	asparagine synthase
HM988_RS18035	COG0517	IMP dehydrogenase activity
HM988_RS18035	COG0617	tRNA 3'-terminal CCA addition
HM988_RS18035	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HM988_RS18040	COG1612	heme a metabolic process
HM988_RS18055	COG1131	(ABC) transporter
HM988_RS18125	COG0556	nucleotide-excision repair
HM988_RS18135	COG2819	hydrolase of the alpha beta superfamily
HM988_RS18145	COG0045	succinate-CoA ligase (ADP-forming) activity
HM988_RS18155	COG0019	diaminopimelate decarboxylase activity
HM988_RS18210	COG2326	polyphosphate kinase activity
HM988_RS18225	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HM988_RS18225	COG3264	Mechanosensitive ion channel
HM988_RS18230	COG1668	transmembrane transport
HM988_RS18235	COG4152	abc transporter atp-binding protein
HM988_RS18240	COG0484	heat shock protein binding
HM988_RS18245	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HM988_RS18260	COG2197	response regulator
HM988_RS18265	COG4585	Histidine kinase
HM988_RS18275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HM988_RS18290	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HM988_RS18290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HM988_RS18295	COG1090	epimerase
HM988_RS18385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HM988_RS18435	COG2949	membrane
HM988_RS18450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM988_RS18455	COG0300	oxidoreductase activity
HM988_RS18480	COG1085	galactose-1-phosphate uridylyltransferase
HM988_RS18485	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HM988_RS18495	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HM988_RS18500	COG3250	beta-galactosidase activity
HM988_RS18525	COG0697	spore germination
HM988_RS18535	COG0800	Aldolase
HM988_RS18540	COG0205	6-phosphofructokinase activity
HM988_RS18560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HM988_RS18565	COG0085	RNA polymerase activity
HM988_RS18570	COG0222	ribosome binding
HM988_RS18575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HM988_RS18580	COG0081	regulation of translation
HM988_RS18585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HM988_RS18605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HM988_RS18630	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HM988_RS18635	COG4974	Belongs to the 'phage' integrase family
HM988_RS18650	COG1115	amino acid carrier protein
HM988_RS18655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HM988_RS18690	COG2323	membrane
HM988_RS18720	COG0577	efflux transmembrane transporter activity
HM988_RS18725	COG3876	Protein conserved in bacteria
HM988_RS18735	COG0584	glycerophosphoryl diester phosphodiesterase
HM988_RS18765	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HM988_RS18780	COG0159	tryptophan synthase activity
HM988_RS18815	COG4628	conserved protein (DUF2132)
HM988_RS18825	COG0513	Belongs to the DEAD box helicase family
HM988_RS18835	COG2957	Belongs to the agmatine deiminase family
HM988_RS18895	COG4251	negative regulation of phosphorylation
HM988_RS18920	COG3022	response to hydroperoxide
HM988_RS18925	COG0564	pseudouridine synthase activity
HM988_RS18935	COG1181	Belongs to the D-alanine--D-alanine ligase family
HM988_RS18940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HM988_RS18990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HM988_RS19025	COG1160	GTP binding
HM988_RS19030	COG1705	Flagellar rod assembly protein muramidase FlgJ
HM988_RS19030	COG1388	LysM domain
HM988_RS19055	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HM988_RS19060	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM988_RS19080	COG4946	Tricorn protease homolog
HM988_RS19080	COG0793	Belongs to the peptidase S41A family
HM988_RS19100	COG1764	response to oxidative stress
HM988_RS19120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM988_RS19195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HM988_RS19205	COG2264	protein methyltransferase activity
HM988_RS19250	COG0149	triose-phosphate isomerase activity
HM988_RS19270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HM988_RS19295	COG1132	(ABC) transporter
HM988_RS19300	COG0101	tRNA pseudouridine synthase activity
HM988_RS19365	COG4968	Prepilin-type N-terminal cleavage methylation domain