locus-tag	class	description
HM987_RS00025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM987_RS00025	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM987_RS00030	COG1619	proteins homologs of microcin C7 resistance protein MccF
HM987_RS00040	COG0792	nuclease activity
HM987_RS00050	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HM987_RS00055	COG0194	GDP metabolic process
HM987_RS00060	COG1561	YicC-like family, N-terminal region
HM987_RS00075	COG0697	spore germination
HM987_RS00100	COG0626	cystathionine gamma-synthase activity
HM987_RS00110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM987_RS00120	COG1381	Involved in DNA repair and RecF pathway recombination
HM987_RS00155	COG2268	Band 7 protein
HM987_RS00180	COG3655	Transcriptional regulator
HM987_RS00190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HM987_RS00205	COG1752	Esterase of the alpha-beta hydrolase superfamily
HM987_RS00210	COG0322	excinuclease ABC activity
HM987_RS00215	COG0189	ligase activity
HM987_RS00215	COG4067	protein conserved in archaea
HM987_RS00220	COG0189	ligase activity
HM987_RS00230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HM987_RS00235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HM987_RS00245	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HM987_RS00270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HM987_RS00280	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HM987_RS00300	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HM987_RS00305	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HM987_RS00310	COG0297	glycogen (starch) synthase activity
HM987_RS00320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HM987_RS00325	COG4771	TonB-dependent receptor
HM987_RS00350	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HM987_RS00360	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HM987_RS00370	COG3483	tryptophan 2,3-dioxygenase activity
HM987_RS00380	COG0166	Belongs to the GPI family
HM987_RS00385	COG4771	TonB-dependent receptor
HM987_RS00405	COG0629	single-stranded DNA binding
HM987_RS00410	COG1194	a g-specific adenine glycosylase
HM987_RS00415	COG0776	regulation of translation
HM987_RS00420	COG1530	ribonuclease E activity
HM987_RS00440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HM987_RS00450	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HM987_RS00490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM987_RS00505	COG2827	Endonuclease containing a URI domain
HM987_RS00510	COG3852	Histidine kinase
HM987_RS00515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HM987_RS00525	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HM987_RS00530	COG0519	Catalyzes the synthesis of GMP from XMP
HM987_RS00545	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HM987_RS00550	COG1968	undecaprenyl-diphosphatase activity
HM987_RS00560	COG2177	Part of the ABC transporter FtsEX involved in
HM987_RS00565	COG0495	leucyl-tRNA aminoacylation
HM987_RS00595	COG4717	serine-type aminopeptidase activity
HM987_RS00600	COG0436	Aminotransferase
HM987_RS00615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HM987_RS00625	COG1040	competence protein
HM987_RS00635	COG0423	glycine-tRNA ligase activity
HM987_RS00650	COG2072	flavoprotein involved in K transport
HM987_RS00660	COG0708	Exodeoxyribonuclease III
HM987_RS00665	COG1360	Flagellar Motor Protein
HM987_RS00670	COG0667	Aldo Keto reductase
HM987_RS00680	COG1522	sequence-specific DNA binding
HM987_RS00695	COG2363	Small membrane protein
HM987_RS00700	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HM987_RS00715	COG0463	Glycosyl transferase, family 2
HM987_RS00720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM987_RS00735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HM987_RS00760	COG0745	RESPONSE REGULATOR receiver
HM987_RS00765	COG5002	protein histidine kinase activity
HM987_RS00770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HM987_RS00775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HM987_RS00790	COG0489	protein tyrosine kinase activity
HM987_RS00795	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HM987_RS00800	COG0492	ferredoxin-NADP+ reductase activity
HM987_RS00805	COG0633	Ferredoxin
HM987_RS00825	COG0628	permease
HM987_RS00830	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HM987_RS00835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HM987_RS00840	COG0228	four-way junction DNA binding
HM987_RS00895	COG4974	Belongs to the 'phage' integrase family
HM987_RS00925	COG0347	Belongs to the P(II) protein family
HM987_RS00960	COG3781	membrane
HM987_RS00975	COG0531	amino acid
HM987_RS01000	COG2217	Heavy metal translocating P-type atpase
HM987_RS01040	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM987_RS01140	COG0629	single-stranded DNA binding
HM987_RS01165	COG1475	DNA binding
HM987_RS01180	COG2839	Protein conserved in bacteria
HM987_RS01220	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HM987_RS01235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HM987_RS01255	COG2315	Protein conserved in bacteria
HM987_RS01260	COG2824	Alkylphosphonate utilization operon protein PhnA
HM987_RS01305	COG2188	Transcriptional regulator
HM987_RS01310	COG1070	Carbohydrate kinase
HM987_RS01315	COG2115	Belongs to the xylose isomerase family
HM987_RS01320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HM987_RS01325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HM987_RS01330	COG2192	nodulation
HM987_RS01340	COG1028	Short-chain dehydrogenase reductase Sdr
HM987_RS01345	COG1312	Catalyzes the dehydration of D-mannonate
HM987_RS01350	COG1312	Catalyzes the dehydration of D-mannonate
HM987_RS01355	COG1904	glucuronate isomerase
HM987_RS01370	COG1069	ribulokinase activity
HM987_RS01380	COG2160	L-arabinose isomerase activity
HM987_RS01390	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM987_RS01405	COG3507	Belongs to the glycosyl hydrolase 43 family
HM987_RS01410	COG1472	Belongs to the glycosyl hydrolase 3 family
HM987_RS01415	COG3507	Belongs to the glycosyl hydrolase 43 family
HM987_RS01440	COG0667	Aldo Keto reductase
HM987_RS01460	COG5520	Belongs to the glycosyl hydrolase 30 family
HM987_RS01475	COG0702	epimerase
HM987_RS01480	COG4771	TonB-dependent receptor
HM987_RS01490	COG2211	Major facilitator Superfamily
HM987_RS01505	COG3661	Belongs to the glycosyl hydrolase 67 family
HM987_RS01510	COG1472	Belongs to the glycosyl hydrolase 3 family
HM987_RS01525	COG1609	Transcriptional regulator
HM987_RS01530	COG1331	Highly conserved protein containing a thioredoxin domain
HM987_RS01545	COG3386	PFAM SMP-30 Gluconolaconase
HM987_RS01555	COG0366	Alpha amylase catalytic
HM987_RS01570	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HM987_RS01575	COG4206	TonB-dependent receptor
HM987_RS01575	COG1629	transport
HM987_RS01590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HM987_RS01595	COG1554	hydrolase, family 65, central catalytic
HM987_RS01600	COG0366	Alpha amylase catalytic
HM987_RS01605	COG1501	Belongs to the glycosyl hydrolase 31 family
HM987_RS01610	COG1523	belongs to the glycosyl hydrolase 13 family
HM987_RS01620	COG0366	Alpha amylase catalytic
HM987_RS01625	COG1082	Xylose isomerase domain protein TIM barrel
HM987_RS01645	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HM987_RS01665	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM987_RS01685	COG2081	HI0933 family
HM987_RS01690	COG2205	protein histidine kinase activity
HM987_RS01690	COG0784	Response regulator, receiver
HM987_RS01730	COG1187	pseudouridine synthase activity
HM987_RS01745	COG3547	Transposase (IS116 IS110 IS902 family)
HM987_RS01760	COG1166	arginine decarboxylase activity
HM987_RS01765	COG0010	Belongs to the arginase family
HM987_RS01770	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HM987_RS01775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HM987_RS01775	COG3153	acetyltransferase
HM987_RS01800	COG1215	transferase activity, transferring glycosyl groups
HM987_RS01805	COG0463	Glycosyl transferase, family 2
HM987_RS01815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HM987_RS01840	COG0463	Glycosyl transferase, family 2
HM987_RS01855	COG2226	methyltransferase
HM987_RS01860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HM987_RS01885	COG3608	succinylglutamate desuccinylase aspartoacylase
HM987_RS01885	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HM987_RS01900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HM987_RS01915	COG0590	tRNA wobble adenosine to inosine editing
HM987_RS01935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HM987_RS01950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HM987_RS01955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HM987_RS01960	COG0066	3-isopropylmalate dehydratase activity
HM987_RS01970	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HM987_RS01975	COG0004	ammonium transporteR
HM987_RS01980	COG0347	Belongs to the P(II) protein family
HM987_RS01985	COG0004	ammonium transporteR
HM987_RS01995	COG0069	glutamate synthase activity
HM987_RS01995	COG0070	glutamate synthase
HM987_RS01995	COG0067	glutamate synthase
HM987_RS02005	COG0140	phosphoribosyl-ATP diphosphatase activity
HM987_RS02005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HM987_RS02010	COG0107	imidazoleglycerol-phosphate synthase activity
HM987_RS02015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HM987_RS02020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HM987_RS02025	COG0131	Imidazoleglycerol-phosphate dehydratase
HM987_RS02030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HM987_RS02035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HM987_RS02040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HM987_RS02045	COG0165	Argininosuccinate lyase
HM987_RS02055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HM987_RS02060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HM987_RS02065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM987_RS02075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HM987_RS02080	COG0137	argininosuccinate synthase activity
HM987_RS02090	COG1012	belongs to the aldehyde dehydrogenase family
HM987_RS02095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HM987_RS02100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HM987_RS02110	COG0028	Belongs to the TPP enzyme family
HM987_RS02115	COG0129	dihydroxy-acid dehydratase activity
HM987_RS02120	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM987_RS02130	COG4771	TonB-dependent receptor
HM987_RS02135	COG0702	epimerase
HM987_RS02170	COG3250	beta-galactosidase activity
HM987_RS02180	COG3119	arylsulfatase activity
HM987_RS02195	COG0477	Major facilitator Superfamily
HM987_RS02195	COG2814	Major facilitator Superfamily
HM987_RS02250	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HM987_RS02290	COG2827	Endonuclease containing a URI domain
HM987_RS02305	COG3104	oligopeptide transport
HM987_RS02310	COG3104	oligopeptide transport
HM987_RS02320	COG2333	competence protein COMEC
HM987_RS02320	COG0658	competence protein
HM987_RS02325	COG0791	NLP P60 protein
HM987_RS02330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM987_RS02335	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HM987_RS02340	COG0793	Belongs to the peptidase S41A family
HM987_RS02345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HM987_RS02350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HM987_RS02355	COG2267	carboxylic ester hydrolase activity
HM987_RS02360	COG2001	Belongs to the MraZ family
HM987_RS02365	COG0275	rRNA processing
HM987_RS02380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HM987_RS02385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM987_RS02395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HM987_RS02400	COG0772	Belongs to the SEDS family
HM987_RS02405	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HM987_RS02410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HM987_RS02425	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HM987_RS02430	COG1610	YqeY-like protein
HM987_RS02450	COG1289	transmembrane transporter activity
HM987_RS02455	COG0069	glutamate synthase activity
HM987_RS02505	COG0529	Catalyzes the synthesis of activated sulfate
HM987_RS02510	COG0175	sulfate reduction
HM987_RS02525	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HM987_RS02530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM987_RS02545	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HM987_RS02590	COG2030	dehydratase
HM987_RS02600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM987_RS02615	COG0438	transferase activity, transferring glycosyl groups
HM987_RS02620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HM987_RS02625	COG0463	Glycosyl transferase, family 2
HM987_RS02665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM987_RS02670	COG0110	maltose O-acetyltransferase activity
HM987_RS02680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM987_RS02695	COG0517	IMP dehydrogenase activity
HM987_RS02700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HM987_RS02705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HM987_RS02715	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HM987_RS02720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HM987_RS02725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HM987_RS02730	COG1215	transferase activity, transferring glycosyl groups
HM987_RS02775	COG1185	polyribonucleotide nucleotidyltransferase activity
HM987_RS02780	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HM987_RS02785	COG3290	protein histidine kinase activity
HM987_RS02790	COG2205	protein histidine kinase activity
HM987_RS02800	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HM987_RS02805	COG0191	fructose-bisphosphate aldolase activity
HM987_RS02815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM987_RS02825	COG2226	methyltransferase
HM987_RS02830	COG0569	domain protein
HM987_RS02850	COG0436	Aminotransferase
HM987_RS02855	COG3239	Fatty acid desaturase
HM987_RS02860	COG0357	Ribosomal RNA small subunit methyltransferase G
HM987_RS02875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM987_RS02890	COG1012	belongs to the aldehyde dehydrogenase family
HM987_RS02900	COG2967	ApaG domain
HM987_RS02905	COG0076	glutamate decarboxylase activity
HM987_RS02920	COG1805	sodium ion transport
HM987_RS02925	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HM987_RS02960	COG2311	Membrane
HM987_RS02965	COG2311	Membrane
HM987_RS02970	COG2267	carboxylic ester hydrolase activity
HM987_RS03020	COG1477	protein flavinylation
HM987_RS03030	COG2226	methyltransferase
HM987_RS03050	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HM987_RS03065	COG3340	Belongs to the peptidase S51 family
HM987_RS03095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HM987_RS03120	COG1028	Short-chain dehydrogenase reductase Sdr
HM987_RS03140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HM987_RS03145	COG3844	kynureninase activity
HM987_RS03175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HM987_RS03180	COG1663	tetraacyldisaccharide 4'-kinase activity
HM987_RS03185	COG2205	protein histidine kinase activity
HM987_RS03185	COG0784	Response regulator, receiver
HM987_RS03190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HM987_RS03195	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HM987_RS03225	COG1595	DNA-templated transcription, initiation
HM987_RS03230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HM987_RS03235	COG0436	Aminotransferase
HM987_RS03245	COG0525	valine-tRNA ligase activity
HM987_RS03250	COG0772	Belongs to the SEDS family
HM987_RS03255	COG0768	penicillin binding
HM987_RS03270	COG1077	Cell shape determining protein MreB Mrl
HM987_RS03275	COG0138	bifunctional purine biosynthesis protein purh
HM987_RS03285	COG2373	Large extracellular alpha-helical protein
HM987_RS03310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HM987_RS03315	COG3002	Belongs to the UPF0753 family
HM987_RS03325	COG2274	protein secretion by the type I secretion system
HM987_RS03340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HM987_RS03345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM987_RS03380	COG2003	Belongs to the UPF0758 family
HM987_RS03390	COG1011	Hydrolase
HM987_RS03400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HM987_RS03410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM987_RS03420	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HM987_RS03425	COG0049	tRNA binding
HM987_RS03430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HM987_RS03435	COG0051	transcription antitermination factor activity, RNA binding
HM987_RS03440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HM987_RS03445	COG0088	Forms part of the polypeptide exit tunnel
HM987_RS03450	COG0089	rRNA binding
HM987_RS03455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HM987_RS03460	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HM987_RS03465	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HM987_RS03470	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HM987_RS03475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HM987_RS03480	COG0255	Belongs to the universal ribosomal protein uL29 family
HM987_RS03485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HM987_RS03490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HM987_RS03495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HM987_RS03500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HM987_RS03505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HM987_RS03510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HM987_RS03515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HM987_RS03520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HM987_RS03525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HM987_RS03530	COG1841	ribosomal large subunit assembly
HM987_RS03535	COG0200	Binds to the 23S rRNA
HM987_RS03540	COG0201	protein transport
HM987_RS03545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HM987_RS03550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HM987_RS03555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HM987_RS03560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HM987_RS03565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HM987_RS03570	COG0202	RNA polymerase activity
HM987_RS03575	COG0203	ribosomal protein L17
HM987_RS03585	COG0148	phosphopyruvate hydratase activity
HM987_RS03615	COG0688	phosphatidylethanolamine metabolic process
HM987_RS03620	COG4589	Belongs to the CDS family
HM987_RS03630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HM987_RS03635	COG0799	negative regulation of ribosome biogenesis
HM987_RS03650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HM987_RS03690	COG5002	protein histidine kinase activity
HM987_RS03695	COG4676	Protein conserved in bacteria
HM987_RS03700	COG0018	arginyl-trna synthetase
HM987_RS03715	COG2318	DinB family
HM987_RS03745	COG0433	COG0433 Predicted ATPase
HM987_RS03755	COG0662	Cupin 2, conserved barrel domain protein
HM987_RS03755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HM987_RS03780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HM987_RS03790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HM987_RS03795	COG0602	queuosine metabolic process
HM987_RS03805	COG0367	asparagine synthase
HM987_RS03810	COG0187	DNA topoisomerase II activity
HM987_RS03815	COG0784	Response regulator, receiver
HM987_RS03815	COG5002	protein histidine kinase activity
HM987_RS03840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HM987_RS03860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HM987_RS03865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HM987_RS03870	COG0215	cysteine-tRNA ligase activity
HM987_RS03875	COG0302	gtp cyclohydrolase
HM987_RS03900	COG0442	prolyl-tRNA aminoacylation
HM987_RS03910	COG0268	Binds directly to 16S ribosomal RNA
HM987_RS03930	COG0673	inositol 2-dehydrogenase activity
HM987_RS03950	COG0784	Response regulator, receiver
HM987_RS03955	COG4251	negative regulation of phosphorylation
HM987_RS03990	COG2356	endonuclease I
HM987_RS04000	COG0174	glutamine synthetase
HM987_RS04020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HM987_RS04030	COG1129	ABC transporter
HM987_RS04040	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HM987_RS04050	COG0284	orotidine-5'-phosphate decarboxylase activity
HM987_RS04055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HM987_RS04070	COG0788	formyltetrahydrofolate deformylase activity
HM987_RS04075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM987_RS04075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM987_RS04075	COG1703	isobutyryl-CoA mutase activity
HM987_RS04095	COG1522	sequence-specific DNA binding
HM987_RS04105	COG0492	ferredoxin-NADP+ reductase activity
HM987_RS04115	COG2814	Major facilitator Superfamily
HM987_RS04130	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HM987_RS04160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HM987_RS04170	COG0463	Glycosyl transferase, family 2
HM987_RS04185	COG2244	polysaccharide biosynthetic process
HM987_RS04205	COG0438	transferase activity, transferring glycosyl groups
HM987_RS04215	COG1216	Glycosyl transferase, family 2
HM987_RS04215	COG1442	glycosyl transferase family 8
HM987_RS04235	COG2884	Cell division ATP-binding protein ftsE
HM987_RS04240	COG0133	tryptophan synthase activity
HM987_RS04245	COG0135	phosphoribosylanthranilate isomerase activity
HM987_RS04250	COG0134	indole-3-glycerol-phosphate synthase activity
HM987_RS04255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HM987_RS04260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HM987_RS04260	COG0512	Glutamine amidotransferase of anthranilate synthase
HM987_RS04265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HM987_RS04275	COG1846	Transcriptional regulator
HM987_RS04290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HM987_RS04310	COG3852	Histidine kinase
HM987_RS04335	COG0577	efflux transmembrane transporter activity
HM987_RS04335	COG1136	(ABC) transporter
HM987_RS04340	COG0577	efflux transmembrane transporter activity
HM987_RS04350	COG0577	efflux transmembrane transporter activity
HM987_RS04365	COG1136	(ABC) transporter
HM987_RS04395	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM987_RS04400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM987_RS04405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM987_RS04445	COG1047	Peptidyl-prolyl cis-trans
HM987_RS04455	COG1349	DNA-binding transcription factor activity
HM987_RS04460	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HM987_RS04465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HM987_RS04470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HM987_RS04480	COG4771	TonB-dependent receptor
HM987_RS04505	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HM987_RS04520	COG3047	cAMP biosynthetic process
HM987_RS04520	COG2885	chlorophyll binding
HM987_RS04525	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HM987_RS04535	COG1482	cell wall glycoprotein biosynthetic process
HM987_RS04570	COG1073	alpha beta
HM987_RS04595	COG1595	DNA-templated transcription, initiation
HM987_RS04610	COG0513	Belongs to the DEAD box helicase family
HM987_RS04615	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HM987_RS04635	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HM987_RS04655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM987_RS04665	COG4771	TonB-dependent receptor
HM987_RS04670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM987_RS04680	COG0326	Molecular chaperone. Has ATPase activity
HM987_RS04690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM987_RS04825	COG3609	addiction module antidote protein, CC2985 family
HM987_RS04850	COG2732	(Barnase) inhibitor
HM987_RS04870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM987_RS04890	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HM987_RS04915	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM987_RS04920	COG1902	pentaerythritol trinitrate reductase activity
HM987_RS04925	COG0450	alkyl hydroperoxide reductase
HM987_RS04945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HM987_RS04950	COG0179	Fumarylacetoacetate (FAA) hydrolase
HM987_RS04960	COG1546	Belongs to the CinA family
HM987_RS04960	COG1058	Belongs to the CinA family
HM987_RS04965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HM987_RS04970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HM987_RS04980	COG0552	protein localization to endoplasmic reticulum
HM987_RS04985	COG0154	amidase activity
HM987_RS05005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM987_RS05020	COG0656	L-ascorbic acid biosynthetic process
HM987_RS05075	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HM987_RS05115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HM987_RS05115	COG0519	Catalyzes the synthesis of GMP from XMP
HM987_RS05135	COG0504	CTP synthase activity
HM987_RS05140	COG0706	membrane insertase activity
HM987_RS05145	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM987_RS05155	COG0482	sulfurtransferase activity
HM987_RS05200	COG0534	Mate efflux family protein
HM987_RS05210	COG0671	phosphoesterase, PA-phosphatase related
HM987_RS05215	COG0671	phosphoesterase, PA-phosphatase related
HM987_RS05225	COG3952	Lipid A Biosynthesis
HM987_RS05225	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM987_RS05230	COG0463	Glycosyl transferase, family 2
HM987_RS05245	COG1595	DNA-templated transcription, initiation
HM987_RS05260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM987_RS05320	COG2827	Endonuclease containing a URI domain
HM987_RS05325	COG0653	protein targeting
HM987_RS05340	COG1136	(ABC) transporter
HM987_RS05350	COG0488	(ABC) transporter
HM987_RS05360	COG0489	protein tyrosine kinase activity
HM987_RS05360	COG3206	protein involved in exopolysaccharide biosynthesis
HM987_RS05365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM987_RS05370	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HM987_RS05415	COG2089	acid synthase
HM987_RS05425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HM987_RS05430	COG1083	cytidylyl-transferase
HM987_RS05490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM987_RS05505	COG1183	phosphatidylcholine synthase activity
HM987_RS05510	COG2354	Protein conserved in bacteria
HM987_RS05515	COG1137	ATPase activity
HM987_RS05520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HM987_RS05525	COG0805	protein transport
HM987_RS05530	COG0517	IMP dehydrogenase activity
HM987_RS05530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HM987_RS05535	COG0514	ATP-dependent DNA helicase (RecQ)
HM987_RS05545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM987_RS05600	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HM987_RS05610	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HM987_RS05620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HM987_RS05650	COG0681	Belongs to the peptidase S26 family
HM987_RS05655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HM987_RS05665	COG1475	DNA binding
HM987_RS05670	COG1192	Involved in chromosome partitioning
HM987_RS05675	COG1028	Short-chain dehydrogenase reductase Sdr
HM987_RS05685	COG4946	Tricorn protease homolog
HM987_RS05685	COG1506	peptidase
HM987_RS05685	COG0823	Involved in the tonB-independent uptake of proteins
HM987_RS05690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM987_RS05690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM987_RS05700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM987_RS05710	COG0572	uridine kinase
HM987_RS05715	COG2010	Cytochrome c
HM987_RS05735	COG2169	Transcriptional regulator
HM987_RS05735	COG1917	Cupin 2, conserved barrel domain protein
HM987_RS05740	COG0656	L-ascorbic acid biosynthetic process
HM987_RS05745	COG0667	Aldo Keto reductase
HM987_RS05750	COG0667	Aldo Keto reductase
HM987_RS05755	COG0716	FMN binding
HM987_RS05770	COG1073	alpha beta
HM987_RS05805	COG5002	protein histidine kinase activity
HM987_RS05865	COG1012	belongs to the aldehyde dehydrogenase family
HM987_RS06000	COG0783	Belongs to the Dps family
HM987_RS06015	COG0714	Associated with various cellular activities
HM987_RS06085	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HM987_RS06150	COG3275	phosphorelay sensor kinase activity
HM987_RS06170	COG3279	Response regulator of the LytR AlgR family
HM987_RS06185	COG1595	DNA-templated transcription, initiation
HM987_RS06190	COG3591	Belongs to the peptidase S1B family
HM987_RS06235	COG0598	Magnesium transport protein CorA
HM987_RS06250	COG0424	maF-like protein
HM987_RS06290	COG1970	mechanosensitive ion channel activity
HM987_RS06295	COG1333	cytochrome c biogenesis protein
HM987_RS06295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HM987_RS06305	COG0626	cystathionine gamma-synthase activity
HM987_RS06315	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HM987_RS06320	COG0471	metal ion transport
HM987_RS06320	COG0490	domain, Protein
HM987_RS06325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HM987_RS06335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM987_RS06345	COG1132	(ABC) transporter
HM987_RS06350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM987_RS06355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HM987_RS06365	COG1862	Preprotein translocase
HM987_RS06370	COG4206	TonB-dependent receptor
HM987_RS06370	COG1629	transport
HM987_RS06375	COG3011	Protein conserved in bacteria
HM987_RS06385	COG1288	antiporter activity
HM987_RS06390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HM987_RS06400	COG0813	purine-nucleoside phosphorylase activity
HM987_RS06420	COG0022	dehydrogenase e1 component
HM987_RS06425	COG0071	Belongs to the small heat shock protein (HSP20) family
HM987_RS06445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HM987_RS06455	COG2195	Cleaves the N-terminal amino acid of tripeptides
HM987_RS06460	COG0589	response to stress
HM987_RS06465	COG0167	dihydroorotate dehydrogenase activity
HM987_RS06510	COG0516	GMP reductase activity
HM987_RS06510	COG0517	IMP dehydrogenase activity
HM987_RS06530	COG0693	protein deglycase activity
HM987_RS06535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HM987_RS06570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HM987_RS06585	COG0714	Associated with various cellular activities
HM987_RS06605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HM987_RS06620	COG0742	ribosomal rna small subunit methyltransferase
HM987_RS06635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM987_RS06650	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HM987_RS06665	COG1454	alcohol dehydrogenase
HM987_RS06685	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HM987_RS06700	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HM987_RS06710	COG1295	ribonuclease BN
HM987_RS06715	COG3279	Response regulator of the LytR AlgR family
HM987_RS06720	COG3275	phosphorelay sensor kinase activity
HM987_RS06755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HM987_RS06760	COG3279	Response regulator of the LytR AlgR family
HM987_RS06765	COG0360	Binds together with S18 to 16S ribosomal RNA
HM987_RS06770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HM987_RS06775	COG0359	binds to the 23S rRNA
HM987_RS06780	COG0584	glycerophosphoryl diester phosphodiesterase
HM987_RS06795	COG1136	(ABC) transporter
HM987_RS06795	COG0577	efflux transmembrane transporter activity
HM987_RS06800	COG0124	histidyl-tRNA synthetase
HM987_RS06805	COG4409	exo-alpha-(2->6)-sialidase activity
HM987_RS06825	COG0471	metal ion transport
HM987_RS06850	COG0732	type I restriction modification DNA specificity domain
HM987_RS06895	COG0367	asparagine synthase
HM987_RS06915	COG1858	cytochrome C peroxidase
HM987_RS06985	COG1678	Uncharacterized ACR, COG1678
HM987_RS06995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM987_RS07000	COG0514	ATP-dependent DNA helicase (RecQ)
HM987_RS07020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HM987_RS07035	COG0415	Belongs to the DNA photolyase family
HM987_RS07055	COG0386	Belongs to the glutathione peroxidase family
HM987_RS07060	COG0300	oxidoreductase activity
HM987_RS07070	COG0302	gtp cyclohydrolase
HM987_RS07085	COG0415	Belongs to the DNA photolyase family
HM987_RS07090	COG3046	protein related to deoxyribodipyrimidine photolyase
HM987_RS07095	COG0415	Belongs to the DNA photolyase family
HM987_RS07105	COG0702	epimerase
HM987_RS07130	COG0673	inositol 2-dehydrogenase activity
HM987_RS07160	COG0673	inositol 2-dehydrogenase activity
HM987_RS07175	COG3177	Filamentation induced by cAMP protein fic
HM987_RS07280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM987_RS07315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HM987_RS07320	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HM987_RS07330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HM987_RS07345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HM987_RS07350	COG3959	Transketolase, thiamine diphosphate binding domain
HM987_RS07355	COG0343	queuine tRNA-ribosyltransferase activity
HM987_RS07370	COG0825	malonyl-CoA metabolic process
HM987_RS07375	COG0305	Participates in initiation and elongation during chromosome replication
HM987_RS07415	COG0561	phosphatase activity
HM987_RS07420	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HM987_RS07425	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HM987_RS07430	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HM987_RS07435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HM987_RS07465	COG0564	pseudouridine synthase activity
HM987_RS07470	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HM987_RS07475	COG1760	l-serine dehydratase
HM987_RS07490	COG0443	Heat shock 70 kDa protein
HM987_RS07495	COG2986	histidine ammonia-lyase
HM987_RS07550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HM987_RS07555	COG1388	LysM domain
HM987_RS07555	COG0791	NLP P60 protein
HM987_RS07565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HM987_RS07585	COG0540	Belongs to the ATCase OTCase family
HM987_RS07595	COG1234	tRNA 3'-trailer cleavage
HM987_RS07600	COG0259	pyridoxamine-phosphate oxidase activity
HM987_RS07625	COG2885	chlorophyll binding
HM987_RS07645	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HM987_RS07660	COG2234	aminopeptidase activity
HM987_RS07700	COG2217	Heavy metal translocating P-type atpase
HM987_RS07720	COG2202	Pas domain
HM987_RS07720	COG1366	Belongs to the anti-sigma-factor antagonist family
HM987_RS07745	COG0589	response to stress
HM987_RS07765	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HM987_RS07780	COG0589	response to stress
HM987_RS07800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HM987_RS07810	COG2885	chlorophyll binding
HM987_RS07835	COG0335	large ribosomal subunit rRNA binding
HM987_RS07840	COG0336	Belongs to the RNA methyltransferase TrmD family
HM987_RS07845	COG0095	Lipoate-protein ligase
HM987_RS07850	COG0596	Alpha beta hydrolase
HM987_RS07865	COG0339	signal peptide processing
HM987_RS07870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM987_RS07875	COG0494	nUDIX hydrolase
HM987_RS07895	COG1252	NADH dehydrogenase
HM987_RS07910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HM987_RS07920	COG0798	PFAM Bile acid sodium symporter
HM987_RS07950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HM987_RS07960	COG0083	homoserine kinase activity
HM987_RS07965	COG0460	homoserine dehydrogenase
HM987_RS07965	COG0527	aspartate kinase activity
HM987_RS07970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HM987_RS07975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM987_RS07980	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HM987_RS07985	COG2070	2-Nitropropane dioxygenase
HM987_RS08045	COG4946	Tricorn protease homolog
HM987_RS08045	COG0793	Belongs to the peptidase S41A family
HM987_RS08050	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HM987_RS08060	COG2996	Protein conserved in bacteria
HM987_RS08075	COG1575	Belongs to the MenA family. Type 1 subfamily
HM987_RS08080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HM987_RS08095	COG4948	Mandelate Racemase Muconate Lactonizing
HM987_RS08110	COG2304	oxidoreductase activity
HM987_RS08125	COG0012	GTP binding
HM987_RS08170	COG0861	Integral membrane protein TerC family
HM987_RS08190	COG1522	sequence-specific DNA binding
HM987_RS08200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HM987_RS08205	COG0506	proline dehydrogenase activity
HM987_RS08225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM987_RS08240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM987_RS08250	COG0367	asparagine synthase
HM987_RS08255	COG0438	transferase activity, transferring glycosyl groups
HM987_RS08270	COG1216	Glycosyl transferase, family 2
HM987_RS08290	COG1216	Glycosyl transferase, family 2
HM987_RS08295	COG5492	domain, Protein
HM987_RS08305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HM987_RS08335	COG0802	atpase or kinase
HM987_RS08340	COG2204	response regulator
HM987_RS08345	COG1078	dGTPase activity
HM987_RS08350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM987_RS08355	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HM987_RS08355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM987_RS08360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM987_RS08365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HM987_RS08370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM987_RS08380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HM987_RS08385	COG0612	Peptidase, M16
HM987_RS08390	COG1028	Short-chain dehydrogenase reductase Sdr
HM987_RS08415	COG0101	tRNA pseudouridine synthase activity
HM987_RS08430	COG0783	Belongs to the Dps family
HM987_RS08435	COG0668	transmembrane transport
HM987_RS08465	COG0668	transmembrane transport
HM987_RS08470	COG2814	Major facilitator Superfamily
HM987_RS08475	COG1278	Cold shock
HM987_RS08480	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM987_RS08495	COG4942	peptidase
HM987_RS08515	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HM987_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
HM987_RS08535	COG0513	Belongs to the DEAD box helicase family
HM987_RS08550	COG1278	Cold shock
HM987_RS08575	COG1012	belongs to the aldehyde dehydrogenase family
HM987_RS08580	COG4221	oxidoreductase activity
HM987_RS08590	COG1902	pentaerythritol trinitrate reductase activity
HM987_RS08615	COG0210	DNA helicase
HM987_RS08635	COG4251	negative regulation of phosphorylation
HM987_RS08650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM987_RS08665	COG2135	peptidase activity
HM987_RS08675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM987_RS08680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM987_RS08700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HM987_RS08715	COG1266	CAAX protease self-immunity
HM987_RS08730	COG3275	phosphorelay sensor kinase activity
HM987_RS08745	COG1131	(ABC) transporter
HM987_RS08750	COG3275	phosphorelay sensor kinase activity
HM987_RS08755	COG3279	Response regulator of the LytR AlgR family
HM987_RS08760	COG3250	beta-galactosidase activity
HM987_RS08765	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM987_RS08770	COG0543	2 iron, 2 sulfur cluster binding
HM987_RS08770	COG0633	Ferredoxin
HM987_RS08790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HM987_RS08795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM987_RS08820	COG1960	acyl-CoA dehydrogenase activity
HM987_RS08840	COG2130	NADP-dependent
HM987_RS08875	COG3279	Response regulator of the LytR AlgR family
HM987_RS08880	COG2972	Histidine kinase
HM987_RS08880	COG0745	RESPONSE REGULATOR receiver
HM987_RS08890	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HM987_RS08895	COG2066	Belongs to the glutaminase family
HM987_RS08905	COG2307	Protein conserved in bacteria
HM987_RS08905	COG2308	Evidence 4 Homologs of previously reported genes of
HM987_RS08930	COG2308	Evidence 4 Homologs of previously reported genes of
HM987_RS08940	COG0322	excinuclease ABC activity
HM987_RS08945	COG3237	CsbD-like
HM987_RS08955	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HM987_RS08960	COG4181	ATPase activity
HM987_RS08980	COG0668	transmembrane transport
HM987_RS08985	COG1752	Esterase of the alpha-beta hydrolase superfamily
HM987_RS09040	COG2267	carboxylic ester hydrolase activity
HM987_RS09075	COG1187	pseudouridine synthase activity
HM987_RS09085	COG2897	thiosulfate sulfurtransferase activity
HM987_RS09090	COG1301	dicarboxylic acid transport
HM987_RS09100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HM987_RS09110	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM987_RS09120	COG0247	lactate metabolic process
HM987_RS09120	COG0277	FAD linked oxidase domain protein
HM987_RS09155	COG3871	stress protein (general stress protein 26)
HM987_RS09170	COG2323	membrane
HM987_RS09175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HM987_RS09185	COG2154	pterin-4-alpha-carbinolamine dehydratase
HM987_RS09190	COG0217	transcriptional regulatory protein
HM987_RS09200	COG4974	Belongs to the 'phage' integrase family
HM987_RS09365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HM987_RS09485	COG1473	amidohydrolase
HM987_RS09525	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HM987_RS09540	COG1674	ftsk spoiiie
HM987_RS09555	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM987_RS09555	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM987_RS09640	COG2205	protein histidine kinase activity
HM987_RS09640	COG3292	Two component regulator propeller
HM987_RS09640	COG0745	RESPONSE REGULATOR receiver
HM987_RS09645	COG2205	protein histidine kinase activity
HM987_RS09645	COG3292	Two component regulator propeller
HM987_RS09645	COG0745	RESPONSE REGULATOR receiver
HM987_RS09650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM987_RS09655	COG0778	Nitroreductase
HM987_RS09665	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HM987_RS09685	COG1984	allophanate hydrolase subunit 2
HM987_RS09690	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HM987_RS09695	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HM987_RS09725	COG0606	chelatase, subunit chli
HM987_RS09755	COG0429	hydrolase of the alpha beta-hydrolase fold
HM987_RS09760	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HM987_RS09785	COG0513	Belongs to the DEAD box helicase family
HM987_RS09800	COG1595	DNA-templated transcription, initiation
HM987_RS09815	COG3275	phosphorelay sensor kinase activity
HM987_RS09820	COG3279	Response regulator of the LytR AlgR family
HM987_RS09830	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HM987_RS09835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HM987_RS09850	COG0626	cystathionine gamma-synthase activity
HM987_RS09865	COG0450	alkyl hydroperoxide reductase
HM987_RS09870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM987_RS09880	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HM987_RS09895	COG0488	(ABC) transporter
HM987_RS09905	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HM987_RS09915	COG0300	oxidoreductase activity
HM987_RS09950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HM987_RS09960	COG0564	pseudouridine synthase activity
HM987_RS09985	COG0542	response to heat
HM987_RS09995	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HM987_RS10000	COG0813	purine-nucleoside phosphorylase activity
HM987_RS10015	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HM987_RS10035	COG2936	dipeptidyl-peptidase activity
HM987_RS10040	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HM987_RS10045	COG0673	inositol 2-dehydrogenase activity
HM987_RS10050	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM987_RS10070	COG2176	DNA-directed DNA polymerase activity
HM987_RS10080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HM987_RS10085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HM987_RS10105	COG0237	dephospho-CoA kinase activity
HM987_RS10130	COG0497	DNA recombination
HM987_RS10155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HM987_RS10170	COG0737	Belongs to the 5'-nucleotidase family
HM987_RS10180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HM987_RS10185	COG2890	protein-(glutamine-N5) methyltransferase activity
HM987_RS10200	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HM987_RS10200	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HM987_RS10205	COG1011	Hydrolase
HM987_RS10210	COG0697	spore germination
HM987_RS10220	COG1739	Uncharacterized protein family UPF0029
HM987_RS10225	COG0824	Thioesterase
HM987_RS10230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HM987_RS10235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HM987_RS10245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HM987_RS10260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HM987_RS10270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HM987_RS10275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HM987_RS10390	COG3547	Transposase (IS116 IS110 IS902 family)
HM987_RS10435	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HM987_RS10495	COG2378	regulation of single-species biofilm formation
HM987_RS10505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HM987_RS10515	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HM987_RS10520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM987_RS10575	COG2382	esterase
HM987_RS10580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HM987_RS10600	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HM987_RS10615	COG2755	lipolytic protein G-D-S-L family
HM987_RS10630	COG1228	amidohydrolase
HM987_RS10640	COG0010	Belongs to the arginase family
HM987_RS10710	COG0488	(ABC) transporter
HM987_RS10720	COG1741	Belongs to the pirin family
HM987_RS10740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HM987_RS10780	COG0205	6-phosphofructokinase activity
HM987_RS10790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HM987_RS10820	COG0628	permease
HM987_RS10840	COG1793	dna ligase
HM987_RS10840	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HM987_RS10870	COG4251	negative regulation of phosphorylation
HM987_RS10875	COG4251	negative regulation of phosphorylation
HM987_RS10880	COG0784	Response regulator, receiver
HM987_RS10890	COG2201	protein-glutamate methylesterase activity
HM987_RS10895	COG1480	7TM receptor with intracellular HD hydrolase
HM987_RS10900	COG0183	Belongs to the thiolase family
HM987_RS10905	COG0791	NLP P60 protein
HM987_RS10910	COG3063	Type IV pilus biogenesis stability protein PilW
HM987_RS10920	COG0542	response to heat
HM987_RS10930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HM987_RS10940	COG0366	Alpha amylase catalytic
HM987_RS10945	COG3387	PFAM Glycoside hydrolase 15-related
HM987_RS10950	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HM987_RS10955	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HM987_RS10960	COG0297	glycogen (starch) synthase activity
HM987_RS10965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM987_RS10985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HM987_RS10995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HM987_RS11030	COG1418	mRNA catabolic process
HM987_RS11065	COG1104	cysteine desulfurase activity
HM987_RS11095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM987_RS11110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HM987_RS11130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HM987_RS11135	COG1702	phosphate starvation-inducible protein PhoH
HM987_RS11165	COG0592	DNA-directed DNA polymerase activity
HM987_RS11190	COG1294	oxidase, subunit
HM987_RS11195	COG1271	oxidase subunit
HM987_RS11225	COG0471	metal ion transport
HM987_RS11225	COG3273	potassium ion transport
HM987_RS11270	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HM987_RS11290	COG1028	Short-chain dehydrogenase reductase Sdr
HM987_RS11325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM987_RS11340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HM987_RS11345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM987_RS11365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HM987_RS11395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HM987_RS11395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HM987_RS11420	COG1846	Transcriptional regulator
HM987_RS11425	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM987_RS11425	COG1024	Enoyl-CoA hydratase
HM987_RS11430	COG0183	Belongs to the thiolase family
HM987_RS11440	COG1960	acyl-CoA dehydrogenase activity
HM987_RS11445	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM987_RS11475	COG2234	aminopeptidase activity
HM987_RS11480	COG0739	heme binding
HM987_RS11530	COG2217	Heavy metal translocating P-type atpase
HM987_RS11550	COG2010	Cytochrome c
HM987_RS11555	COG0348	domain, Protein
HM987_RS11580	COG0589	response to stress
HM987_RS11585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HM987_RS11590	COG2032	superoxide dismutase activity
HM987_RS11605	COG1272	protein, Hemolysin III
HM987_RS11615	COG1363	Peptidase, m42
HM987_RS11625	COG2339	peptidase activity
HM987_RS11635	COG0439	Biotin carboxylase
HM987_RS11640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HM987_RS11645	COG1132	(ABC) transporter
HM987_RS11655	COG2814	Major facilitator Superfamily
HM987_RS11660	COG0009	L-threonylcarbamoyladenylate synthase
HM987_RS11695	COG0438	transferase activity, transferring glycosyl groups
HM987_RS11700	COG1472	Belongs to the glycosyl hydrolase 3 family
HM987_RS11705	COG0560	Phosphoserine phosphatase
HM987_RS11705	COG3830	Belongs to the UPF0237 family
HM987_RS11725	COG0247	lactate metabolic process
HM987_RS11725	COG2181	nitrate reductase activity
HM987_RS11730	COG0247	lactate metabolic process
HM987_RS11730	COG2181	nitrate reductase activity
HM987_RS11735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HM987_RS11740	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM987_RS11750	COG0251	oxidation-reduction process
HM987_RS11765	COG0516	GMP reductase activity
HM987_RS11790	COG4251	negative regulation of phosphorylation
HM987_RS11800	COG1215	transferase activity, transferring glycosyl groups
HM987_RS11810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM987_RS11855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HM987_RS11860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HM987_RS11875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HM987_RS11940	COG0156	8-amino-7-oxononanoate synthase activity
HM987_RS11955	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HM987_RS11970	COG1393	Belongs to the ArsC family
HM987_RS11990	COG1064	alcohol dehydrogenase
HM987_RS12000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HM987_RS12010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HM987_RS12020	COG1012	belongs to the aldehyde dehydrogenase family
HM987_RS12030	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM987_RS12040	COG1115	amino acid carrier protein
HM987_RS12080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HM987_RS12105	COG1120	ATPase activity
HM987_RS12110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HM987_RS12140	COG4640	response to antibiotic
HM987_RS12185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HM987_RS12190	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HM987_RS12200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HM987_RS12225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM987_RS12230	COG4166	transmembrane transport
HM987_RS12245	COG0254	rRNA binding
HM987_RS12260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HM987_RS12265	COG1132	(ABC) transporter
HM987_RS12270	COG1595	DNA-templated transcription, initiation
HM987_RS12285	COG0179	Fumarylacetoacetate (FAA) hydrolase
HM987_RS12295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HM987_RS12305	COG1611	Belongs to the LOG family
HM987_RS12340	COG0116	Belongs to the methyltransferase superfamily
HM987_RS12340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HM987_RS12345	COG2226	methyltransferase
HM987_RS12415	COG0105	UTP biosynthetic process
HM987_RS12420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HM987_RS12430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM987_RS12435	COG2195	Cleaves the N-terminal amino acid of tripeptides
HM987_RS12470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM987_RS12475	COG0501	Belongs to the peptidase M48B family
HM987_RS12490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HM987_RS12500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HM987_RS12510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM987_RS12530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HM987_RS12555	COG3956	TIGRFAM MazG family protein
HM987_RS12565	COG0242	peptide deformylase activity
HM987_RS12570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HM987_RS12575	COG3549	Plasmid maintenance system killer
HM987_RS12585	COG2171	N-acyltransferase activity
HM987_RS12605	COG0463	Glycosyl transferase, family 2
HM987_RS12610	COG1215	transferase activity, transferring glycosyl groups
HM987_RS12615	COG0463	Glycosyl transferase, family 2
HM987_RS12620	COG0726	polysaccharide deacetylase
HM987_RS12630	COG0463	Glycosyl transferase, family 2
HM987_RS12650	COG0367	asparagine synthase
HM987_RS12675	COG0617	tRNA 3'-terminal CCA addition
HM987_RS12675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HM987_RS12675	COG0517	IMP dehydrogenase activity
HM987_RS12680	COG1612	heme a metabolic process
HM987_RS12695	COG1131	(ABC) transporter
HM987_RS12765	COG0556	nucleotide-excision repair
HM987_RS12775	COG2819	hydrolase of the alpha beta superfamily
HM987_RS12785	COG0045	succinate-CoA ligase (ADP-forming) activity
HM987_RS12795	COG0019	diaminopimelate decarboxylase activity
HM987_RS12850	COG2326	polyphosphate kinase activity
HM987_RS12865	COG3264	Mechanosensitive ion channel
HM987_RS12865	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HM987_RS12870	COG1668	transmembrane transport
HM987_RS12875	COG4152	abc transporter atp-binding protein
HM987_RS12880	COG0484	heat shock protein binding
HM987_RS12885	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HM987_RS12900	COG2197	response regulator
HM987_RS12905	COG4585	Histidine kinase
HM987_RS12915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HM987_RS12930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HM987_RS12930	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HM987_RS12935	COG1090	epimerase
HM987_RS13025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HM987_RS13075	COG2949	membrane
HM987_RS13090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM987_RS13095	COG0300	oxidoreductase activity
HM987_RS13120	COG1085	galactose-1-phosphate uridylyltransferase
HM987_RS13125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HM987_RS13135	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HM987_RS13140	COG3250	beta-galactosidase activity
HM987_RS13165	COG0697	spore germination
HM987_RS13175	COG0800	Aldolase
HM987_RS13180	COG0205	6-phosphofructokinase activity
HM987_RS13200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HM987_RS13205	COG0085	RNA polymerase activity
HM987_RS13210	COG0222	ribosome binding
HM987_RS13215	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HM987_RS13220	COG0081	regulation of translation
HM987_RS13225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HM987_RS13245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HM987_RS13270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HM987_RS13275	COG4974	Belongs to the 'phage' integrase family
HM987_RS13290	COG1115	amino acid carrier protein
HM987_RS13295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HM987_RS13330	COG2323	membrane
HM987_RS13360	COG0577	efflux transmembrane transporter activity
HM987_RS13365	COG3876	Protein conserved in bacteria
HM987_RS13375	COG0584	glycerophosphoryl diester phosphodiesterase
HM987_RS13405	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HM987_RS13420	COG0159	tryptophan synthase activity
HM987_RS13455	COG4628	conserved protein (DUF2132)
HM987_RS13465	COG0513	Belongs to the DEAD box helicase family
HM987_RS13475	COG2957	Belongs to the agmatine deiminase family
HM987_RS13540	COG4251	negative regulation of phosphorylation
HM987_RS13565	COG3022	response to hydroperoxide
HM987_RS13570	COG0564	pseudouridine synthase activity
HM987_RS13580	COG1181	Belongs to the D-alanine--D-alanine ligase family
HM987_RS13585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HM987_RS13635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HM987_RS13670	COG1160	GTP binding
HM987_RS13675	COG1705	Flagellar rod assembly protein muramidase FlgJ
HM987_RS13675	COG1388	LysM domain
HM987_RS13700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HM987_RS13705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM987_RS13725	COG0793	Belongs to the peptidase S41A family
HM987_RS13725	COG4946	Tricorn protease homolog
HM987_RS13745	COG1764	response to oxidative stress
HM987_RS13765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM987_RS13840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HM987_RS13850	COG2264	protein methyltransferase activity
HM987_RS13895	COG0149	triose-phosphate isomerase activity
HM987_RS13915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HM987_RS13940	COG1132	(ABC) transporter
HM987_RS13945	COG0101	tRNA pseudouridine synthase activity
HM987_RS14010	COG4968	Prepilin-type N-terminal cleavage methylation domain
HM987_RS14100	COG1028	Short-chain dehydrogenase reductase Sdr
HM987_RS14105	COG1028	Short-chain dehydrogenase reductase Sdr
HM987_RS14135	COG1629	transport
HM987_RS14135	COG4206	TonB-dependent receptor
HM987_RS14140	COG1621	beta-fructofuranosidase activity
HM987_RS14145	COG2814	Major facilitator Superfamily
HM987_RS14150	COG3292	Two component regulator propeller
HM987_RS14150	COG2205	protein histidine kinase activity
HM987_RS14150	COG0745	RESPONSE REGULATOR receiver
HM987_RS14185	COG0488	(ABC) transporter
HM987_RS14195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HM987_RS14215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM987_RS14240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM987_RS14270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HM987_RS14275	COG0459	protein refolding
HM987_RS14330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HM987_RS14335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HM987_RS14340	COG0563	adenylate kinase activity
HM987_RS14345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HM987_RS14360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HM987_RS14365	COG0339	signal peptide processing
HM987_RS14425	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HM987_RS14425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HM987_RS14430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM987_RS14440	COG1215	transferase activity, transferring glycosyl groups
HM987_RS14465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HM987_RS14470	COG1127	ABC transporter
HM987_RS14495	COG2304	oxidoreductase activity
HM987_RS14520	COG0484	heat shock protein binding
HM987_RS14530	COG1028	Short-chain dehydrogenase reductase Sdr
HM987_RS14540	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM987_RS14550	COG0295	cytidine deaminase activity
HM987_RS14565	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM987_RS14570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HM987_RS14575	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HM987_RS14595	COG0285	dihydrofolate synthase activity
HM987_RS14605	COG0848	biopolymer transport protein
HM987_RS14610	COG0811	peptide transport
HM987_RS14615	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HM987_RS14630	COG1960	acyl-CoA dehydrogenase activity
HM987_RS14635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM987_RS14685	COG1629	transport
HM987_RS14690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HM987_RS14715	COG0321	lipoyl(octanoyl) transferase activity
HM987_RS14725	COG0401	homolog of Blt101
HM987_RS14730	COG2197	response regulator
HM987_RS14745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HM987_RS14780	COG4682	membrane
HM987_RS14800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HM987_RS14810	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HM987_RS14835	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HM987_RS14845	COG0659	secondary active sulfate transmembrane transporter activity
HM987_RS14850	COG1278	Cold shock
HM987_RS14855	COG2076	Multidrug Resistance protein
HM987_RS14870	COG0358	DNA primase activity
HM987_RS14875	COG2197	response regulator
HM987_RS14880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HM987_RS14930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HM987_RS14935	COG3396	Phenylacetate-CoA oxygenase
HM987_RS14940	COG3460	Phenylacetate-CoA oxygenase
HM987_RS14945	COG3396	Phenylacetate-CoA oxygenase
HM987_RS14950	COG2151	metal-sulfur cluster biosynthetic enzyme
HM987_RS14955	COG1024	Enoyl-CoA hydratase
HM987_RS14965	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM987_RS14975	COG2321	neutral zinc metallopeptidase
HM987_RS14980	COG0183	Belongs to the thiolase family
HM987_RS14985	COG2030	dehydratase
HM987_RS14985	COG1012	belongs to the aldehyde dehydrogenase family
HM987_RS15005	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM987_RS15010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HM987_RS15015	COG0022	dehydrogenase e1 component
HM987_RS15030	COG1595	DNA-templated transcription, initiation
HM987_RS15045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HM987_RS15055	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HM987_RS15060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HM987_RS15080	COG1988	membrane-bound metal-dependent
HM987_RS15085	COG1490	D-aminoacyl-tRNA deacylase activity
HM987_RS15090	COG1162	GTPase activity
HM987_RS15100	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HM987_RS15105	COG0287	Prephenate dehydrogenase
HM987_RS15110	COG0436	Aminotransferase
HM987_RS15115	COG1605	Chorismate mutase
HM987_RS15115	COG0077	Prephenate dehydratase
HM987_RS15120	COG1131	(ABC) transporter
HM987_RS15125	COG0857	belongs to the CobB CobQ family
HM987_RS15125	COG0280	phosphate acetyltransferase
HM987_RS15130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HM987_RS15150	COG1045	serine acetyltransferase
HM987_RS15155	COG0492	ferredoxin-NADP+ reductase activity
HM987_RS15165	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HM987_RS15175	COG1959	2 iron, 2 sulfur cluster binding
HM987_RS15180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HM987_RS15190	COG1131	(ABC) transporter
HM987_RS15195	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HM987_RS15210	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HM987_RS15215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HM987_RS15225	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HM987_RS15230	COG2086	electron transfer activity
HM987_RS15235	COG0022	dehydrogenase e1 component
HM987_RS15235	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM987_RS15260	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HM987_RS15265	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HM987_RS15315	COG1428	Deoxynucleoside kinase
HM987_RS15320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HM987_RS15335	COG3174	membrane
HM987_RS15340	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HM987_RS15345	COG0110	maltose O-acetyltransferase activity
HM987_RS15350	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HM987_RS15355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HM987_RS15365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM987_RS15370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HM987_RS15400	COG4242	Belongs to the peptidase S51 family
HM987_RS15415	COG0702	epimerase
HM987_RS15420	COG4771	TonB-dependent receptor
HM987_RS15465	COG1609	Transcriptional regulator
HM987_RS15480	COG2211	Major facilitator Superfamily
HM987_RS15525	COG0702	epimerase
HM987_RS15530	COG4771	TonB-dependent receptor
HM987_RS15545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HM987_RS15570	COG4680	protein conserved in bacteria
HM987_RS15585	COG0463	Glycosyl transferase, family 2
HM987_RS15595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM987_RS15625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM987_RS15630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM987_RS15660	COG1131	(ABC) transporter
HM987_RS15675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM987_RS15685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM987_RS15700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM987_RS15705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM987_RS15710	COG1028	Short-chain dehydrogenase reductase Sdr
HM987_RS15730	COG2755	lipolytic protein G-D-S-L family
HM987_RS15730	COG0657	acetylesterase activity
HM987_RS15735	COG2755	lipolytic protein G-D-S-L family
HM987_RS15750	COG0673	inositol 2-dehydrogenase activity
HM987_RS15755	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HM987_RS15800	COG4771	TonB-dependent receptor
HM987_RS15805	COG0702	epimerase
HM987_RS15830	COG2721	sulfolactate sulfo-lyase activity
HM987_RS15835	COG0246	Mannitol dehydrogenase
HM987_RS15850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HM987_RS15855	COG1904	glucuronate isomerase
HM987_RS15860	COG1028	Short-chain dehydrogenase reductase Sdr
HM987_RS15865	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HM987_RS15880	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HM987_RS15890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HM987_RS15895	COG1428	Deoxynucleoside kinase
HM987_RS15915	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HM987_RS15920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HM987_RS15930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HM987_RS15950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HM987_RS15960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HM987_RS15970	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HM987_RS15975	COG0596	Alpha beta hydrolase
HM987_RS15985	COG1950	PFAM Membrane protein of
HM987_RS15990	COG0544	peptidyl-prolyl cis-trans isomerase activity
HM987_RS15995	COG0740	serine-type endopeptidase activity
HM987_RS16000	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HM987_RS16030	COG0745	RESPONSE REGULATOR receiver
HM987_RS16030	COG2972	Histidine kinase
HM987_RS16055	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HM987_RS16065	COG0668	transmembrane transport
HM987_RS16070	COG1214	PFAM Peptidase M22, glycoprotease
HM987_RS16085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM987_RS16090	COG0577	efflux transmembrane transporter activity
HM987_RS16090	COG1136	(ABC) transporter
HM987_RS16095	COG1136	(ABC) transporter
HM987_RS16095	COG0577	efflux transmembrane transporter activity
HM987_RS16100	COG1136	(ABC) transporter
HM987_RS16110	COG2322	membrane
HM987_RS16115	COG1999	signal sequence binding
HM987_RS16135	COG1845	cytochrome c oxidase, subunit III
HM987_RS16140	COG0109	protoheme IX farnesyltransferase activity
HM987_RS16185	COG0509	glycine decarboxylation via glycine cleavage system
HM987_RS16195	COG0632	four-way junction helicase activity
HM987_RS16200	COG0281	malic enzyme
HM987_RS16200	COG0280	phosphate acetyltransferase
HM987_RS16215	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HM987_RS16245	COG3292	Two component regulator propeller
HM987_RS16245	COG0745	RESPONSE REGULATOR receiver
HM987_RS16245	COG2205	protein histidine kinase activity
HM987_RS16250	COG2124	cytochrome p450
HM987_RS16255	COG2255	four-way junction helicase activity
HM987_RS16260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HM987_RS16265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HM987_RS16290	COG0437	4 iron, 4 sulfur cluster binding
HM987_RS16310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HM987_RS16315	COG0195	Participates in both transcription termination and antitermination
HM987_RS16320	COG0779	Required for maturation of 30S ribosomal subunits
HM987_RS16345	COG3118	belongs to the thioredoxin family
HM987_RS16355	COG4585	Histidine kinase
HM987_RS16360	COG3279	Response regulator of the LytR AlgR family
HM987_RS16395	COG0189	ligase activity
HM987_RS16395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HM987_RS16400	COG4242	Belongs to the peptidase S51 family
HM987_RS16410	COG3292	Two component regulator propeller
HM987_RS16410	COG0745	RESPONSE REGULATOR receiver
HM987_RS16410	COG2205	protein histidine kinase activity
HM987_RS16430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM987_RS16430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM987_RS16475	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HM987_RS16490	COG1032	radical SAM domain protein
HM987_RS16495	COG0488	(ABC) transporter
HM987_RS16520	COG0009	L-threonylcarbamoyladenylate synthase
HM987_RS16525	COG0589	response to stress
HM987_RS16530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HM987_RS16535	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HM987_RS16540	COG0052	Belongs to the universal ribosomal protein uS2 family
HM987_RS16545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HM987_RS16550	COG0528	UMP kinase activity
HM987_RS16555	COG0233	cytoplasmic translational termination
HM987_RS16570	COG0017	Asparaginyl-tRNA synthetase
HM987_RS16575	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HM987_RS16595	COG0848	biopolymer transport protein
HM987_RS16605	COG0811	peptide transport
HM987_RS16615	COG0252	asparaginase activity
HM987_RS16620	COG0084	hydrolase, TatD family'
HM987_RS16635	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM987_RS16660	COG1309	transcriptional regulator
HM987_RS16675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HM987_RS16680	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HM987_RS16695	COG1278	Cold shock
HM987_RS16705	COG0590	tRNA wobble adenosine to inosine editing
HM987_RS16715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HM987_RS16725	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HM987_RS16730	COG4771	TonB-dependent receptor
HM987_RS16775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HM987_RS16780	COG1328	CTP reductase activity
HM987_RS16780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HM987_RS16785	COG3279	Response regulator of the LytR AlgR family
HM987_RS16790	COG3275	phosphorelay sensor kinase activity
HM987_RS16810	COG2095	MarC family integral membrane protein
HM987_RS16860	COG0793	Belongs to the peptidase S41A family
HM987_RS16880	COG0646	methionine synthase
HM987_RS16880	COG1410	methionine synthase
HM987_RS16890	COG1410	methionine synthase
HM987_RS16890	COG0646	methionine synthase
HM987_RS16895	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HM987_RS16900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM987_RS16905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HM987_RS16915	COG0314	molybdopterin synthase activity
HM987_RS16935	COG0746	molybdenum cofactor guanylyltransferase activity
HM987_RS16940	COG0730	response to heat
HM987_RS16940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HM987_RS16950	COG0303	'Molybdopterin
HM987_RS16965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HM987_RS16970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HM987_RS16975	COG0193	aminoacyl-tRNA hydrolase activity
HM987_RS16985	COG0196	riboflavin kinase activity
HM987_RS16995	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HM987_RS17015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HM987_RS17020	COG2239	Acts as a magnesium transporter
HM987_RS17030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM987_RS17035	COG1233	COG1233 Phytoene dehydrogenase and related
HM987_RS17040	COG2197	response regulator
HM987_RS17075	COG0527	aspartate kinase activity
HM987_RS17085	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HM987_RS17095	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HM987_RS17110	COG1652	LysM domain
HM987_RS17120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HM987_RS17130	COG1309	transcriptional regulator
HM987_RS17140	COG1538	Outer membrane efflux protein
HM987_RS17160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HM987_RS17185	COG0288	reversible hydration of carbon dioxide
HM987_RS17190	COG0659	secondary active sulfate transmembrane transporter activity
HM987_RS17240	COG2304	oxidoreductase activity
HM987_RS17255	COG0714	Associated with various cellular activities
HM987_RS17265	COG4989	oxidoreductase activity
HM987_RS17300	COG1012	belongs to the aldehyde dehydrogenase family
HM987_RS17320	COG2329	Antibiotic biosynthesis monooxygenase
HM987_RS17330	COG4953	penicillin-binding protein 1C
HM987_RS17380	COG0612	Peptidase, M16
HM987_RS17385	COG0612	Peptidase, M16
HM987_RS17390	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HM987_RS17395	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HM987_RS17405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HM987_RS17410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HM987_RS17420	COG1053	succinate dehydrogenase
HM987_RS17440	COG0006	proline dipeptidase activity
HM987_RS17445	COG0494	nUDIX hydrolase
HM987_RS17450	COG1061	Type III restriction enzyme res subunit
HM987_RS17455	COG0527	aspartate kinase activity
HM987_RS17480	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HM987_RS17490	COG0316	Belongs to the HesB IscA family
HM987_RS17495	COG0719	Fe-S assembly protein
HM987_RS17510	COG0396	ATPase activity
HM987_RS17515	COG0719	Fe-S assembly protein
HM987_RS17540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HM987_RS17550	COG2166	iron-sulfur cluster assembly
HM987_RS17555	COG2151	metal-sulfur cluster biosynthetic enzyme
HM987_RS17585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HM987_RS17610	COG2954	triphosphatase activity
HM987_RS17615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HM987_RS17625	COG0469	pyruvate kinase activity
HM987_RS17635	COG0571	ribonuclease III activity
HM987_RS17640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM987_RS17645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM987_RS17655	COG3341	Caulimovirus viroplasmin
HM987_RS17655	COG0328	RNA-DNA hybrid ribonuclease activity
HM987_RS17690	COG1074	ATP-dependent DNA helicase activity
HM987_RS17695	COG0156	8-amino-7-oxononanoate synthase activity
HM987_RS17715	COG0784	Response regulator, receiver
HM987_RS17715	COG2205	protein histidine kinase activity
HM987_RS17750	COG0720	synthase
HM987_RS17755	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM987_RS17775	COG3047	cAMP biosynthetic process
HM987_RS17775	COG2885	chlorophyll binding
HM987_RS17780	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HM987_RS17780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HM987_RS17815	COG4771	TonB-dependent receptor
HM987_RS17815	COG4771	TonB-dependent receptor
HM987_RS17820	COG4206	TonB-dependent receptor
HM987_RS17820	COG1629	transport
HM987_RS17825	COG1573	uracil-dna glycosylase
HM987_RS17840	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HM987_RS17860	COG1435	thymidine kinase activity
HM987_RS17865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HM987_RS17870	COG1970	mechanosensitive ion channel activity
HM987_RS17875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HM987_RS17880	COG1505	serine-type exopeptidase activity
HM987_RS17900	COG3842	ATPase activity
HM987_RS17945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM987_RS17960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM987_RS17965	COG3424	synthase
HM987_RS17975	COG1233	COG1233 Phytoene dehydrogenase and related
HM987_RS17990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HM987_RS17995	COG2022	thiamine diphosphate biosynthetic process
HM987_RS17995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HM987_RS18005	COG0439	Biotin carboxylase
HM987_RS18010	COG0511	ligase activity, forming carbon-carbon bonds
HM987_RS18015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM987_RS18020	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HM987_RS18030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HM987_RS18055	COG0489	protein tyrosine kinase activity
HM987_RS18055	COG3206	protein involved in exopolysaccharide biosynthesis
HM987_RS18065	COG1215	transferase activity, transferring glycosyl groups
HM987_RS18085	COG1216	Glycosyl transferase, family 2
HM987_RS18105	COG2089	acid synthase
HM987_RS18135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM987_RS18140	COG1086	Polysaccharide biosynthesis protein
HM987_RS18145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM987_RS18190	COG0346	lactoylglutathione lyase activity
HM987_RS18195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HM987_RS18205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HM987_RS18220	COG2234	aminopeptidase activity
HM987_RS18235	COG0481	GTPase activity
HM987_RS18240	COG3263	regulation of cellular component size
HM987_RS18250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HM987_RS18270	COG0594	ribonuclease P activity
HM987_RS18275	COG0793	Belongs to the peptidase S41A family
HM987_RS18285	COG2153	protein acetylation
HM987_RS18295	COG0698	ribose 5-phosphate isomerase
HM987_RS18305	COG0557	exoribonuclease II activity
HM987_RS18310	COG0393	Putative heavy-metal-binding
HM987_RS18345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HM987_RS18375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HM987_RS18385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HM987_RS18390	COG0445	tRNA wobble uridine modification
HM987_RS18410	COG0470	DNA polymerase III
HM987_RS18415	COG0126	phosphoglycerate kinase activity
HM987_RS18420	COG1388	LysM domain
HM987_RS18420	COG0791	NLP P60 protein
HM987_RS18430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HM987_RS18465	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HM987_RS18470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HM987_RS18480	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HM987_RS18530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM987_RS18540	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HM987_RS18560	COG1215	transferase activity, transferring glycosyl groups
HM987_RS18565	COG0151	Belongs to the GarS family
HM987_RS18580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HM987_RS18590	COG0859	PFAM glycosyl transferase family 9
HM987_RS18595	COG0633	Ferredoxin
HM987_RS18640	COG0356	it plays a direct role in the translocation of protons across the membrane
HM987_RS18645	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HM987_RS18650	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HM987_RS18655	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HM987_RS18660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HM987_RS18670	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HM987_RS18695	COG0756	dUTP diphosphatase activity
HM987_RS18700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HM987_RS18725	COG1607	acyl-coa hydrolase
HM987_RS18735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HM987_RS18735	COG0758	DNA mediated transformation
HM987_RS18765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HM987_RS18775	COG0741	lytic transglycosylase activity
HM987_RS18775	COG1196	nuclear chromosome segregation
HM987_RS18775	COG0739	heme binding
HM987_RS18780	COG1774	PSP1 C-terminal conserved region
HM987_RS18790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HM987_RS18795	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HM987_RS18820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HM987_RS18825	COG1253	flavin adenine dinucleotide binding
HM987_RS18830	COG1522	sequence-specific DNA binding
HM987_RS18835	COG0113	porphobilinogen synthase activity
HM987_RS18845	COG0408	coproporphyrinogen oxidase activity
HM987_RS18860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HM987_RS18865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HM987_RS18875	COG0181	hydroxymethylbilane synthase activity
HM987_RS18880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HM987_RS18905	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HM987_RS18920	COG5000	phosphorelay sensor kinase activity
HM987_RS18925	COG1024	Enoyl-CoA hydratase
HM987_RS18930	COG3177	Filamentation induced by cAMP protein fic
HM987_RS18950	COG2207	Transcriptional regulator
HM987_RS18960	COG1418	mRNA catabolic process
HM987_RS18985	COG0484	heat shock protein binding
HM987_RS19000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HM987_RS19005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HM987_RS19020	COG1121	(ABC) transporter
HM987_RS19025	COG0803	Belongs to the bacterial solute-binding protein 9 family
HM987_RS19055	COG1999	signal sequence binding
HM987_RS19120	COG1204	response to ionizing radiation
HM987_RS19135	COG2003	Belongs to the UPF0758 family
HM987_RS19205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM987_RS19225	COG0516	GMP reductase activity
HM987_RS19225	COG0517	IMP dehydrogenase activity
HM987_RS19235	COG0629	single-stranded DNA binding
HM987_RS19295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM987_RS19310	COG1473	amidohydrolase
HM987_RS19320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HM987_RS19325	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HM987_RS19330	COG2080	2 iron, 2 sulfur cluster binding
HM987_RS19400	COG1528	Iron-storage protein
HM987_RS19440	COG1595	DNA-templated transcription, initiation
HM987_RS19445	COG3712	iron ion homeostasis
HM987_RS19455	COG0123	including yeast histone deacetylase and acetoin utilization protein
HM987_RS19465	COG2183	response to ionizing radiation