locus-tag	class	description
BWZ20_RS00085	COG3657	addiction module killer protein
BWZ20_RS00195	COG3657	addiction module killer protein
BWZ20_RS00215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BWZ20_RS00370	COG3549	Plasmid maintenance system killer
BWZ20_RS00395	COG2826	transposase and inactivated derivatives, IS30 family
BWZ20_RS00535	COG2732	(Barnase) inhibitor
BWZ20_RS00665	COG4974	Belongs to the 'phage' integrase family
BWZ20_RS00680	COG2226	methyltransferase
BWZ20_RS00685	COG0116	Belongs to the methyltransferase superfamily
BWZ20_RS00685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BWZ20_RS00695	COG2226	methyltransferase
BWZ20_RS00715	COG0022	dehydrogenase e1 component
BWZ20_RS00730	COG1611	Belongs to the LOG family
BWZ20_RS00760	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BWZ20_RS00770	COG0732	type I restriction modification DNA specificity domain
BWZ20_RS00785	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BWZ20_RS00815	COG0793	Belongs to the peptidase S41A family
BWZ20_RS00815	COG4946	Tricorn protease homolog
BWZ20_RS00820	COG0405	Gamma-glutamyltransferase
BWZ20_RS00825	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
BWZ20_RS00830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BWZ20_RS00850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWZ20_RS00855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BWZ20_RS00860	COG0730	response to heat
BWZ20_RS00865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BWZ20_RS00865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BWZ20_RS00870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BWZ20_RS00890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWZ20_RS00910	COG3275	phosphorelay sensor kinase activity
BWZ20_RS00950	COG0592	DNA-directed DNA polymerase activity
BWZ20_RS00980	COG1702	phosphate starvation-inducible protein PhoH
BWZ20_RS00985	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BWZ20_RS01015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BWZ20_RS01050	COG1104	cysteine desulfurase activity
BWZ20_RS01085	COG1418	mRNA catabolic process
BWZ20_RS01090	COG4974	Belongs to the 'phage' integrase family
BWZ20_RS01105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BWZ20_RS01115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BWZ20_RS01125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWZ20_RS01130	COG0297	glycogen (starch) synthase activity
BWZ20_RS01135	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BWZ20_RS01140	COG0366	Alpha amylase catalytic
BWZ20_RS01150	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BWZ20_RS01180	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BWZ20_RS01185	COG0754	glutathionylspermidine amidase activity
BWZ20_RS01225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BWZ20_RS01230	COG0791	NLP P60 protein
BWZ20_RS01230	COG1388	LysM domain
BWZ20_RS01240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BWZ20_RS01245	COG1652	LysM domain
BWZ20_RS01245	COG2823	Periplasmic or secreted lipoprotein
BWZ20_RS01260	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BWZ20_RS01265	COG0540	Belongs to the ATCase OTCase family
BWZ20_RS01275	COG1234	tRNA 3'-trailer cleavage
BWZ20_RS01285	COG0259	pyridoxamine-phosphate oxidase activity
BWZ20_RS01300	COG2885	chlorophyll binding
BWZ20_RS01320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BWZ20_RS01350	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BWZ20_RS01375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BWZ20_RS01380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BWZ20_RS01390	COG1454	alcohol dehydrogenase
BWZ20_RS01420	COG0583	DNA-binding transcription factor activity
BWZ20_RS01430	COG0217	transcriptional regulatory protein
BWZ20_RS01435	COG2154	pterin-4-alpha-carbinolamine dehydratase
BWZ20_RS01445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BWZ20_RS01455	COG0247	lactate metabolic process
BWZ20_RS01455	COG0277	FAD linked oxidase domain protein
BWZ20_RS01465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BWZ20_RS01470	COG1301	dicarboxylic acid transport
BWZ20_RS01475	COG0189	ligase activity
BWZ20_RS01500	COG3011	Protein conserved in bacteria
BWZ20_RS01515	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BWZ20_RS01545	COG0022	dehydrogenase e1 component
BWZ20_RS01580	COG1187	pseudouridine synthase activity
BWZ20_RS01640	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
BWZ20_RS01645	COG1047	Peptidyl-prolyl cis-trans
BWZ20_RS01650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BWZ20_RS01680	COG4251	negative regulation of phosphorylation
BWZ20_RS01710	COG1902	pentaerythritol trinitrate reductase activity
BWZ20_RS01720	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BWZ20_RS01725	COG0739	heme binding
BWZ20_RS01730	COG0551	DNA topoisomerase type I activity
BWZ20_RS01730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BWZ20_RS01740	COG1278	Cold shock
BWZ20_RS01755	COG2814	Major facilitator Superfamily
BWZ20_RS01760	COG0668	transmembrane transport
BWZ20_RS01785	COG1309	transcriptional regulator
BWZ20_RS01790	COG1028	Short-chain dehydrogenase reductase Sdr
BWZ20_RS01815	COG0668	transmembrane transport
BWZ20_RS01820	COG0783	Belongs to the Dps family
BWZ20_RS01835	COG0101	tRNA pseudouridine synthase activity
BWZ20_RS01855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BWZ20_RS01855	COG0140	phosphoribosyl-ATP diphosphatase activity
BWZ20_RS01860	COG0107	imidazoleglycerol-phosphate synthase activity
BWZ20_RS01865	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BWZ20_RS01875	COG0131	Imidazoleglycerol-phosphate dehydratase
BWZ20_RS01880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BWZ20_RS01885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BWZ20_RS01890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BWZ20_RS01905	COG1028	Short-chain dehydrogenase reductase Sdr
BWZ20_RS01910	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BWZ20_RS01915	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWZ20_RS01920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BWZ20_RS01925	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWZ20_RS01930	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BWZ20_RS01930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BWZ20_RS01935	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWZ20_RS01940	COG1078	dGTPase activity
BWZ20_RS01945	COG2204	response regulator
BWZ20_RS01950	COG0802	atpase or kinase
BWZ20_RS01975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BWZ20_RS01980	COG0438	transferase activity, transferring glycosyl groups
BWZ20_RS02000	COG5492	domain, Protein
BWZ20_RS02010	COG1045	serine acetyltransferase
BWZ20_RS02035	COG0367	asparagine synthase
BWZ20_RS02045	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BWZ20_RS02050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BWZ20_RS02070	COG0726	polysaccharide deacetylase
BWZ20_RS02075	COG0506	proline dehydrogenase activity
BWZ20_RS02080	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BWZ20_RS02085	COG1522	sequence-specific DNA binding
BWZ20_RS02105	COG0861	Integral membrane protein TerC family
BWZ20_RS02130	COG0012	GTP binding
BWZ20_RS02165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BWZ20_RS02195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BWZ20_RS02200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BWZ20_RS02215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BWZ20_RS02225	COG2197	response regulator
BWZ20_RS02230	COG4585	Histidine kinase
BWZ20_RS02240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BWZ20_RS02255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWZ20_RS02310	COG0156	8-amino-7-oxononanoate synthase activity
BWZ20_RS02325	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BWZ20_RS02350	COG1393	Belongs to the ArsC family
BWZ20_RS02390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BWZ20_RS02400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BWZ20_RS02405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BWZ20_RS02420	COG0745	RESPONSE REGULATOR receiver
BWZ20_RS02425	COG5002	protein histidine kinase activity
BWZ20_RS02435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BWZ20_RS02455	COG1115	amino acid carrier protein
BWZ20_RS02480	COG0438	transferase activity, transferring glycosyl groups
BWZ20_RS02485	COG1472	Belongs to the glycosyl hydrolase 3 family
BWZ20_RS02490	COG0560	Phosphoserine phosphatase
BWZ20_RS02490	COG3830	Belongs to the UPF0237 family
BWZ20_RS02500	COG2181	nitrate reductase activity
BWZ20_RS02500	COG0247	lactate metabolic process
BWZ20_RS02505	COG0247	lactate metabolic process
BWZ20_RS02505	COG2181	nitrate reductase activity
BWZ20_RS02515	COG0860	N-Acetylmuramoyl-L-alanine amidase
BWZ20_RS02525	COG0251	oxidation-reduction process
BWZ20_RS02570	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BWZ20_RS02595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BWZ20_RS02605	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BWZ20_RS02610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWZ20_RS02680	COG1228	amidohydrolase
BWZ20_RS02700	COG0659	secondary active sulfate transmembrane transporter activity
BWZ20_RS02775	COG0488	(ABC) transporter
BWZ20_RS02785	COG1741	Belongs to the pirin family
BWZ20_RS02790	COG1846	Transcriptional regulator
BWZ20_RS02795	COG2388	GCN5-related N-acetyl-transferase
BWZ20_RS02805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BWZ20_RS02815	COG1803	Methylglyoxal synthase
BWZ20_RS02830	COG0205	6-phosphofructokinase activity
BWZ20_RS02840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BWZ20_RS02850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BWZ20_RS02865	COG0628	permease
BWZ20_RS02900	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BWZ20_RS02900	COG1793	dna ligase
BWZ20_RS02940	COG0183	Belongs to the thiolase family
BWZ20_RS02945	COG0791	NLP P60 protein
BWZ20_RS02960	COG0542	response to heat
BWZ20_RS02970	COG2986	histidine ammonia-lyase
BWZ20_RS02975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BWZ20_RS03020	COG4948	Mandelate Racemase Muconate Lactonizing
BWZ20_RS03055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BWZ20_RS03060	COG1575	Belongs to the MenA family. Type 1 subfamily
BWZ20_RS03080	COG2996	Protein conserved in bacteria
BWZ20_RS03090	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BWZ20_RS03095	COG1169	isochorismate synthase
BWZ20_RS03135	COG2070	2-Nitropropane dioxygenase
BWZ20_RS03140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BWZ20_RS03150	COG0443	Heat shock 70 kDa protein
BWZ20_RS03160	COG1760	l-serine dehydratase
BWZ20_RS03170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BWZ20_RS03175	COG0564	pseudouridine synthase activity
BWZ20_RS03200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BWZ20_RS03210	COG1914	H( )-stimulated, divalent metal cation uptake system
BWZ20_RS03220	COG0606	chelatase, subunit chli
BWZ20_RS03225	COG0429	hydrolase of the alpha beta-hydrolase fold
BWZ20_RS03235	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BWZ20_RS03240	COG0037	tRNA processing
BWZ20_RS03260	COG0513	Belongs to the DEAD box helicase family
BWZ20_RS03270	COG1595	DNA-templated transcription, initiation
BWZ20_RS03290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BWZ20_RS03305	COG1522	sequence-specific DNA binding
BWZ20_RS03320	COG1757	Na H antiporter
BWZ20_RS03325	COG0450	alkyl hydroperoxide reductase
BWZ20_RS03330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWZ20_RS03345	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BWZ20_RS03360	COG0488	(ABC) transporter
BWZ20_RS03370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BWZ20_RS03380	COG0300	oxidoreductase activity
BWZ20_RS03410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BWZ20_RS03445	COG0542	response to heat
BWZ20_RS03450	COG3047	cAMP biosynthetic process
BWZ20_RS03455	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BWZ20_RS03460	COG0813	purine-nucleoside phosphorylase activity
BWZ20_RS03470	COG1028	Short-chain dehydrogenase reductase Sdr
BWZ20_RS03480	COG1216	Glycosyl transferase, family 2
BWZ20_RS03490	COG1028	Short-chain dehydrogenase reductase Sdr
BWZ20_RS03500	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BWZ20_RS03520	COG2936	dipeptidyl-peptidase activity
BWZ20_RS03530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BWZ20_RS03535	COG0673	inositol 2-dehydrogenase activity
BWZ20_RS03540	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWZ20_RS03560	COG0322	excinuclease ABC activity
BWZ20_RS03565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWZ20_RS03570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BWZ20_RS03585	COG0237	dephospho-CoA kinase activity
BWZ20_RS03595	COG1215	transferase activity, transferring glycosyl groups
BWZ20_RS03610	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BWZ20_RS03615	COG0497	DNA recombination
BWZ20_RS03640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BWZ20_RS03650	COG0737	Belongs to the 5'-nucleotidase family
BWZ20_RS03655	COG0737	Belongs to the 5'-nucleotidase family
BWZ20_RS03670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BWZ20_RS03680	COG1611	Belongs to the LOG family
BWZ20_RS03685	COG2890	protein-(glutamine-N5) methyltransferase activity
BWZ20_RS03700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BWZ20_RS03700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BWZ20_RS03705	COG1011	Hydrolase
BWZ20_RS03720	COG1739	Uncharacterized protein family UPF0029
BWZ20_RS03725	COG0824	Thioesterase
BWZ20_RS03730	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BWZ20_RS03735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BWZ20_RS03745	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BWZ20_RS03760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BWZ20_RS03770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BWZ20_RS03775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BWZ20_RS03800	COG0336	Belongs to the RNA methyltransferase TrmD family
BWZ20_RS03805	COG0335	large ribosomal subunit rRNA binding
BWZ20_RS03830	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BWZ20_RS03865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BWZ20_RS03870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BWZ20_RS03875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BWZ20_RS03880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BWZ20_RS03895	COG0432	Pfam Uncharacterised protein family UPF0047
BWZ20_RS03920	COG0305	Participates in initiation and elongation during chromosome replication
BWZ20_RS03925	COG0825	malonyl-CoA metabolic process
BWZ20_RS03940	COG0343	queuine tRNA-ribosyltransferase activity
BWZ20_RS03950	COG3958	Transketolase
BWZ20_RS03965	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BWZ20_RS03975	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BWZ20_RS03980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BWZ20_RS04000	COG1233	COG1233 Phytoene dehydrogenase and related
BWZ20_RS04015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWZ20_RS04030	COG0714	Associated with various cellular activities
BWZ20_RS04035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWZ20_RS04045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWZ20_RS04075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BWZ20_RS04080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BWZ20_RS04085	COG0514	ATP-dependent DNA helicase (RecQ)
BWZ20_RS04090	COG0517	IMP dehydrogenase activity
BWZ20_RS04090	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BWZ20_RS04095	COG0805	protein transport
BWZ20_RS04105	COG1137	ATPase activity
BWZ20_RS04115	COG1253	flavin adenine dinucleotide binding
BWZ20_RS04135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BWZ20_RS04170	COG0438	transferase activity, transferring glycosyl groups
BWZ20_RS04190	COG2089	acid synthase
BWZ20_RS04195	COG1083	cytidylyl-transferase
BWZ20_RS04195	COG2755	lipolytic protein G-D-S-L family
BWZ20_RS04220	COG1216	Glycosyl transferase, family 2
BWZ20_RS04225	COG0438	transferase activity, transferring glycosyl groups
BWZ20_RS04260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BWZ20_RS04265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BWZ20_RS04270	COG0489	protein tyrosine kinase activity
BWZ20_RS04280	COG0488	(ABC) transporter
BWZ20_RS04290	COG1136	(ABC) transporter
BWZ20_RS04305	COG0653	protein targeting
BWZ20_RS04335	COG1595	DNA-templated transcription, initiation
BWZ20_RS04345	COG1703	isobutyryl-CoA mutase activity
BWZ20_RS04350	COG0463	Glycosyl transferase, family 2
BWZ20_RS04355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWZ20_RS04355	COG3952	Lipid A Biosynthesis
BWZ20_RS04365	COG0671	phosphoesterase, PA-phosphatase related
BWZ20_RS04375	COG0534	Mate efflux family protein
BWZ20_RS04405	COG0482	sulfurtransferase activity
BWZ20_RS04415	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BWZ20_RS04420	COG0706	membrane insertase activity
BWZ20_RS04425	COG0504	CTP synthase activity
BWZ20_RS04430	COG3530	Putative quorum-sensing-regulated virulence factor
BWZ20_RS04445	COG1388	LysM domain
BWZ20_RS04445	COG0791	NLP P60 protein
BWZ20_RS04450	COG0519	Catalyzes the synthesis of GMP from XMP
BWZ20_RS04450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BWZ20_RS04485	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BWZ20_RS04495	COG0612	Peptidase, M16
BWZ20_RS04590	COG3279	Response regulator of the LytR AlgR family
BWZ20_RS04595	COG3275	phosphorelay sensor kinase activity
BWZ20_RS04600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWZ20_RS04610	COG0154	amidase activity
BWZ20_RS04615	COG0552	protein localization to endoplasmic reticulum
BWZ20_RS04625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BWZ20_RS04630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BWZ20_RS04635	COG1546	Belongs to the CinA family
BWZ20_RS04635	COG1058	Belongs to the CinA family
BWZ20_RS04645	COG0179	Fumarylacetoacetate (FAA) hydrolase
BWZ20_RS04655	COG2176	DNA-directed DNA polymerase activity
BWZ20_RS04665	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWZ20_RS04675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BWZ20_RS04710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BWZ20_RS04720	COG0326	Molecular chaperone. Has ATPase activity
BWZ20_RS04730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BWZ20_RS04760	COG1595	DNA-templated transcription, initiation
BWZ20_RS04850	COG1482	cell wall glycoprotein biosynthetic process
BWZ20_RS04860	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BWZ20_RS04865	COG2885	chlorophyll binding
BWZ20_RS04880	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BWZ20_RS04895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BWZ20_RS04900	COG0085	RNA polymerase activity
BWZ20_RS04905	COG0222	ribosome binding
BWZ20_RS04910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BWZ20_RS04915	COG0081	regulation of translation
BWZ20_RS04920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BWZ20_RS04940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BWZ20_RS04965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BWZ20_RS04970	COG4974	Belongs to the 'phage' integrase family
BWZ20_RS04975	COG1960	acyl-CoA dehydrogenase activity
BWZ20_RS04985	COG1115	amino acid carrier protein
BWZ20_RS04990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BWZ20_RS05010	COG0577	efflux transmembrane transporter activity
BWZ20_RS05015	COG3876	Protein conserved in bacteria
BWZ20_RS05025	COG0584	glycerophosphoryl diester phosphodiesterase
BWZ20_RS05065	COG2884	Cell division ATP-binding protein ftsE
BWZ20_RS05075	COG1216	Glycosyl transferase, family 2
BWZ20_RS05100	COG2244	polysaccharide biosynthetic process
BWZ20_RS05125	COG0463	Glycosyl transferase, family 2
BWZ20_RS05130	COG1217	gtp-binding protein TYPA
BWZ20_RS05140	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BWZ20_RS05185	COG2949	membrane
BWZ20_RS05195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWZ20_RS05215	COG0668	transmembrane transport
BWZ20_RS05230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWZ20_RS05235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BWZ20_RS05245	COG1012	belongs to the aldehyde dehydrogenase family
BWZ20_RS05265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BWZ20_RS05275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BWZ20_RS05280	COG1846	Transcriptional regulator
BWZ20_RS05290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BWZ20_RS05295	COG0512	Glutamine amidotransferase of anthranilate synthase
BWZ20_RS05295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BWZ20_RS05305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BWZ20_RS05310	COG0134	indole-3-glycerol-phosphate synthase activity
BWZ20_RS05315	COG0135	phosphoribosylanthranilate isomerase activity
BWZ20_RS05320	COG0133	tryptophan synthase activity
BWZ20_RS05325	COG0159	tryptophan synthase activity
BWZ20_RS05330	COG3152	Membrane
BWZ20_RS05350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BWZ20_RS05360	COG3022	response to hydroperoxide
BWZ20_RS05365	COG0564	pseudouridine synthase activity
BWZ20_RS05370	COG0515	serine threonine protein kinase
BWZ20_RS05370	COG2815	serine threonine protein kinase
BWZ20_RS05375	COG1181	Belongs to the D-alanine--D-alanine ligase family
BWZ20_RS05380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BWZ20_RS05390	COG4585	Histidine kinase
BWZ20_RS05415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BWZ20_RS05455	COG1160	GTP binding
BWZ20_RS05465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BWZ20_RS05535	COG0784	Response regulator, receiver
BWZ20_RS05535	COG2205	protein histidine kinase activity
BWZ20_RS05535	COG2198	Histidine kinase
BWZ20_RS05535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BWZ20_RS05540	COG5002	protein histidine kinase activity
BWZ20_RS05550	COG3604	Transcriptional regulator
BWZ20_RS05585	COG0488	(ABC) transporter
BWZ20_RS05595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BWZ20_RS05615	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BWZ20_RS05635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWZ20_RS05670	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BWZ20_RS05675	COG0459	protein refolding
BWZ20_RS05690	COG1473	amidohydrolase
BWZ20_RS05705	COG2608	mercury ion transmembrane transporter activity
BWZ20_RS05735	COG0138	bifunctional purine biosynthesis protein purh
BWZ20_RS05740	COG1077	Cell shape determining protein MreB Mrl
BWZ20_RS05755	COG0768	penicillin binding
BWZ20_RS05760	COG0772	Belongs to the SEDS family
BWZ20_RS05765	COG0473	3-isopropylmalate dehydrogenase activity
BWZ20_RS05770	COG0525	valine-tRNA ligase activity
BWZ20_RS05785	COG0436	Aminotransferase
BWZ20_RS05790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BWZ20_RS05795	COG1595	DNA-templated transcription, initiation
BWZ20_RS05810	COG1216	Glycosyl transferase, family 2
BWZ20_RS05810	COG0463	Glycosyl transferase, family 2
BWZ20_RS05835	COG0471	metal ion transport
BWZ20_RS05855	COG1477	protein flavinylation
BWZ20_RS05860	COG2363	Small membrane protein
BWZ20_RS05865	COG2226	methyltransferase
BWZ20_RS05880	COG0427	acetyl-CoA hydrolase
BWZ20_RS05890	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BWZ20_RS05900	COG0501	Belongs to the peptidase M48B family
BWZ20_RS05910	COG3340	Belongs to the peptidase S51 family
BWZ20_RS05935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BWZ20_RS05960	COG0662	Cupin 2, conserved barrel domain protein
BWZ20_RS05965	COG1028	Short-chain dehydrogenase reductase Sdr
BWZ20_RS05970	COG2827	Endonuclease containing a URI domain
BWZ20_RS05995	COG3844	kynureninase activity
BWZ20_RS06030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BWZ20_RS06035	COG1663	tetraacyldisaccharide 4'-kinase activity
BWZ20_RS06040	COG0784	Response regulator, receiver
BWZ20_RS06040	COG2205	protein histidine kinase activity
BWZ20_RS06045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BWZ20_RS06050	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BWZ20_RS06060	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BWZ20_RS06065	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BWZ20_RS06070	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BWZ20_RS06075	COG1805	sodium ion transport
BWZ20_RS06100	COG2967	ApaG domain
BWZ20_RS06110	COG1012	belongs to the aldehyde dehydrogenase family
BWZ20_RS06120	COG0357	Ribosomal RNA small subunit methyltransferase G
BWZ20_RS06125	COG3239	Fatty acid desaturase
BWZ20_RS06130	COG0436	Aminotransferase
BWZ20_RS06150	COG0569	domain protein
BWZ20_RS06155	COG2226	methyltransferase
BWZ20_RS06175	COG0191	fructose-bisphosphate aldolase activity
BWZ20_RS06180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BWZ20_RS06195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BWZ20_RS06200	COG1185	polyribonucleotide nucleotidyltransferase activity
BWZ20_RS06220	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BWZ20_RS06225	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BWZ20_RS06230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BWZ20_RS06240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BWZ20_RS06245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BWZ20_RS06255	COG0489	protein tyrosine kinase activity
BWZ20_RS06255	COG3206	protein involved in exopolysaccharide biosynthesis
BWZ20_RS06265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BWZ20_RS06290	COG0438	transferase activity, transferring glycosyl groups
BWZ20_RS06335	COG1083	cytidylyl-transferase
BWZ20_RS06340	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BWZ20_RS06345	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BWZ20_RS06350	COG2089	acid synthase
BWZ20_RS06355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BWZ20_RS06360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BWZ20_RS06415	COG1610	YqeY-like protein
BWZ20_RS06420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BWZ20_RS06435	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BWZ20_RS06440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BWZ20_RS06445	COG0772	Belongs to the SEDS family
BWZ20_RS06450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BWZ20_RS06455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BWZ20_RS06460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BWZ20_RS06475	COG0275	rRNA processing
BWZ20_RS06480	COG2001	Belongs to the MraZ family
BWZ20_RS06485	COG2267	carboxylic ester hydrolase activity
BWZ20_RS06490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BWZ20_RS06495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BWZ20_RS06500	COG0793	Belongs to the peptidase S41A family
BWZ20_RS06505	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BWZ20_RS06515	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWZ20_RS06520	COG0791	NLP P60 protein
BWZ20_RS06530	COG1858	cytochrome C peroxidase
BWZ20_RS06535	COG2333	competence protein COMEC
BWZ20_RS06535	COG0658	competence protein
BWZ20_RS06540	COG4232	protein-disulfide reductase activity
BWZ20_RS06545	COG3104	oligopeptide transport
BWZ20_RS06550	COG3104	oligopeptide transport
BWZ20_RS06555	COG0823	Involved in the tonB-independent uptake of proteins
BWZ20_RS06555	COG1506	peptidase
BWZ20_RS06575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BWZ20_RS06605	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BWZ20_RS06615	COG0347	Belongs to the P(II) protein family
BWZ20_RS06620	COG0004	ammonium transporteR
BWZ20_RS06625	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BWZ20_RS06630	COG0590	tRNA wobble adenosine to inosine editing
BWZ20_RS06650	COG4206	TonB-dependent receptor
BWZ20_RS06650	COG1629	transport
BWZ20_RS06680	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BWZ20_RS06720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BWZ20_RS06730	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BWZ20_RS06750	COG1215	transferase activity, transferring glycosyl groups
BWZ20_RS06780	COG1899	peptidyl-lysine modification to peptidyl-hypusine
BWZ20_RS06785	COG0010	Belongs to the arginase family
BWZ20_RS06810	COG1187	pseudouridine synthase activity
BWZ20_RS06850	COG2081	HI0933 family
BWZ20_RS06865	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BWZ20_RS06880	COG1082	Xylose isomerase domain protein TIM barrel
BWZ20_RS06885	COG0366	Alpha amylase catalytic
BWZ20_RS06895	COG1523	belongs to the glycosyl hydrolase 13 family
BWZ20_RS06900	COG1501	Belongs to the glycosyl hydrolase 31 family
BWZ20_RS06905	COG2819	hydrolase of the alpha beta superfamily
BWZ20_RS06910	COG0366	Alpha amylase catalytic
BWZ20_RS06915	COG1554	hydrolase, family 65, central catalytic
BWZ20_RS06920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BWZ20_RS06935	COG1629	transport
BWZ20_RS06935	COG4206	TonB-dependent receptor
BWZ20_RS06940	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BWZ20_RS06950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BWZ20_RS06995	COG3813	Protein conserved in bacteria
BWZ20_RS07000	COG2824	Alkylphosphonate utilization operon protein PhnA
BWZ20_RS07020	COG0110	maltose O-acetyltransferase activity
BWZ20_RS07030	COG0438	transferase activity, transferring glycosyl groups
BWZ20_RS07040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BWZ20_RS07070	COG0745	RESPONSE REGULATOR receiver
BWZ20_RS07075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWZ20_RS07085	COG3279	Response regulator of the LytR AlgR family
BWZ20_RS07095	COG5002	protein histidine kinase activity
BWZ20_RS07105	COG4251	negative regulation of phosphorylation
BWZ20_RS07115	COG0784	Response regulator, receiver
BWZ20_RS07140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BWZ20_RS07145	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BWZ20_RS07205	COG4585	Histidine kinase
BWZ20_RS07245	COG0228	four-way junction DNA binding
BWZ20_RS07250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BWZ20_RS07255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BWZ20_RS07275	COG0633	Ferredoxin
BWZ20_RS07285	COG0492	ferredoxin-NADP+ reductase activity
BWZ20_RS07290	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BWZ20_RS07295	COG0489	protein tyrosine kinase activity
BWZ20_RS07300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BWZ20_RS07310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BWZ20_RS07320	COG5002	protein histidine kinase activity
BWZ20_RS07325	COG0745	RESPONSE REGULATOR receiver
BWZ20_RS07340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BWZ20_RS07345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BWZ20_RS07355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BWZ20_RS07360	COG0463	Glycosyl transferase, family 2
BWZ20_RS07375	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BWZ20_RS07380	COG2363	Small membrane protein
BWZ20_RS07390	COG1522	sequence-specific DNA binding
BWZ20_RS07400	COG2738	Putative neutral zinc metallopeptidase
BWZ20_RS07415	COG0495	leucyl-tRNA aminoacylation
BWZ20_RS07420	COG2177	Part of the ABC transporter FtsEX involved in
BWZ20_RS07435	COG1968	undecaprenyl-diphosphatase activity
BWZ20_RS07440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BWZ20_RS07455	COG0519	Catalyzes the synthesis of GMP from XMP
BWZ20_RS07470	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BWZ20_RS07480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BWZ20_RS07485	COG3852	Histidine kinase
BWZ20_RS07495	COG0537	adenosine 5'-monophosphoramidase activity
BWZ20_RS07500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BWZ20_RS07515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BWZ20_RS07540	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BWZ20_RS07550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BWZ20_RS07570	COG4717	serine-type aminopeptidase activity
BWZ20_RS07575	COG0436	Aminotransferase
BWZ20_RS07600	COG1040	competence protein
BWZ20_RS07610	COG0423	glycine-tRNA ligase activity
BWZ20_RS07625	COG0708	Exodeoxyribonuclease III
BWZ20_RS07630	COG1360	Flagellar Motor Protein
BWZ20_RS07635	COG0667	Aldo Keto reductase
BWZ20_RS07645	COG0017	Asparaginyl-tRNA synthetase
BWZ20_RS07650	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BWZ20_RS07680	COG0811	peptide transport
BWZ20_RS07690	COG0252	asparaginase activity
BWZ20_RS07695	COG0084	hydrolase, TatD family'
BWZ20_RS07705	COG2197	response regulator
BWZ20_RS07730	COG0142	geranyltranstransferase activity
BWZ20_RS07750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BWZ20_RS07755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BWZ20_RS07780	COG0590	tRNA wobble adenosine to inosine editing
BWZ20_RS07785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BWZ20_RS07790	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BWZ20_RS07800	COG1629	transport
BWZ20_RS07800	COG4206	TonB-dependent receptor
BWZ20_RS07830	COG2095	MarC family integral membrane protein
BWZ20_RS07845	COG0793	Belongs to the peptidase S41A family
BWZ20_RS07875	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BWZ20_RS07920	COG3119	arylsulfatase activity
BWZ20_RS07940	COG3119	arylsulfatase activity
BWZ20_RS07950	COG3119	arylsulfatase activity
BWZ20_RS07955	COG3119	arylsulfatase activity
BWZ20_RS07960	COG3119	arylsulfatase activity
BWZ20_RS07965	COG1472	Belongs to the glycosyl hydrolase 3 family
BWZ20_RS07970	COG0702	epimerase
BWZ20_RS07975	COG4771	TonB-dependent receptor
BWZ20_RS07980	COG3292	Two component regulator propeller
BWZ20_RS07980	COG0745	RESPONSE REGULATOR receiver
BWZ20_RS07980	COG2205	protein histidine kinase activity
BWZ20_RS07985	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BWZ20_RS08005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BWZ20_RS08010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BWZ20_RS08015	COG0193	aminoacyl-tRNA hydrolase activity
BWZ20_RS08025	COG0196	riboflavin kinase activity
BWZ20_RS08035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BWZ20_RS08050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BWZ20_RS08055	COG2239	Acts as a magnesium transporter
BWZ20_RS08060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BWZ20_RS08095	COG0527	aspartate kinase activity
BWZ20_RS08105	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BWZ20_RS08120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BWZ20_RS08135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BWZ20_RS08150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BWZ20_RS08170	COG0659	secondary active sulfate transmembrane transporter activity
BWZ20_RS08195	COG2304	oxidoreductase activity
BWZ20_RS08200	COG2304	oxidoreductase activity
BWZ20_RS08215	COG0714	Associated with various cellular activities
BWZ20_RS08225	COG4989	oxidoreductase activity
BWZ20_RS08230	COG4221	oxidoreductase activity
BWZ20_RS08260	COG1012	belongs to the aldehyde dehydrogenase family
BWZ20_RS08265	COG1446	asparaginase
BWZ20_RS08290	COG2373	Large extracellular alpha-helical protein
BWZ20_RS08300	COG2329	Antibiotic biosynthesis monooxygenase
BWZ20_RS08305	COG4953	penicillin-binding protein 1C
BWZ20_RS08345	COG0612	Peptidase, M16
BWZ20_RS08350	COG0612	Peptidase, M16
BWZ20_RS08355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BWZ20_RS08360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BWZ20_RS08365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BWZ20_RS08375	COG1053	succinate dehydrogenase
BWZ20_RS08395	COG0006	proline dipeptidase activity
BWZ20_RS08415	COG0527	aspartate kinase activity
BWZ20_RS08445	COG2267	carboxylic ester hydrolase activity
BWZ20_RS08460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BWZ20_RS08480	COG1858	cytochrome C peroxidase
BWZ20_RS08490	COG0316	Belongs to the HesB IscA family
BWZ20_RS08495	COG0719	Fe-S assembly protein
BWZ20_RS08505	COG0396	ATPase activity
BWZ20_RS08510	COG0719	Fe-S assembly protein
BWZ20_RS08525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BWZ20_RS08535	COG2166	iron-sulfur cluster assembly
BWZ20_RS08540	COG2151	metal-sulfur cluster biosynthetic enzyme
BWZ20_RS08545	COG3425	synthase
BWZ20_RS08560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BWZ20_RS08605	COG2954	triphosphatase activity
BWZ20_RS08610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BWZ20_RS08620	COG0469	pyruvate kinase activity
BWZ20_RS08630	COG0571	ribonuclease III activity
BWZ20_RS08635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BWZ20_RS08640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BWZ20_RS08645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BWZ20_RS08650	COG0328	RNA-DNA hybrid ribonuclease activity
BWZ20_RS08650	COG3341	Caulimovirus viroplasmin
BWZ20_RS08655	COG0351	phosphomethylpyrimidine kinase
BWZ20_RS08655	COG0352	thiamine-phosphate diphosphorylase activity
BWZ20_RS08670	COG1074	ATP-dependent DNA helicase activity
BWZ20_RS08680	COG2885	chlorophyll binding
BWZ20_RS08685	COG0210	DNA helicase
BWZ20_RS08735	COG0720	synthase
BWZ20_RS08740	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BWZ20_RS08755	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BWZ20_RS08755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BWZ20_RS08770	COG4771	TonB-dependent receptor
BWZ20_RS08780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BWZ20_RS08795	COG1435	thymidine kinase activity
BWZ20_RS08800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BWZ20_RS08805	COG1970	mechanosensitive ion channel activity
BWZ20_RS08810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BWZ20_RS08815	COG1505	serine-type exopeptidase activity
BWZ20_RS08830	COG3842	ATPase activity
BWZ20_RS08845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BWZ20_RS08850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BWZ20_RS08855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BWZ20_RS08865	COG3424	synthase
BWZ20_RS08900	COG0439	Biotin carboxylase
BWZ20_RS08905	COG0511	ligase activity, forming carbon-carbon bonds
BWZ20_RS08910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BWZ20_RS08915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BWZ20_RS08925	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BWZ20_RS08930	COG0307	riboflavin synthase, alpha
BWZ20_RS08945	COG0346	lactoylglutathione lyase activity
BWZ20_RS08950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BWZ20_RS08960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BWZ20_RS08975	COG2234	aminopeptidase activity
BWZ20_RS08990	COG0481	GTPase activity
BWZ20_RS09005	COG3263	regulation of cellular component size
BWZ20_RS09010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BWZ20_RS09025	COG2988	succinylglutamate desuccinylase activity
BWZ20_RS09035	COG0594	ribonuclease P activity
BWZ20_RS09040	COG0793	Belongs to the peptidase S41A family
BWZ20_RS09050	COG2153	protein acetylation
BWZ20_RS09060	COG0698	ribose 5-phosphate isomerase
BWZ20_RS09065	COG0557	exoribonuclease II activity
BWZ20_RS09070	COG0393	Putative heavy-metal-binding
BWZ20_RS09100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWZ20_RS09140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BWZ20_RS09145	COG3239	Fatty acid desaturase
BWZ20_RS09155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BWZ20_RS09160	COG0445	tRNA wobble uridine modification
BWZ20_RS09175	COG0470	DNA polymerase III
BWZ20_RS09180	COG0126	phosphoglycerate kinase activity
BWZ20_RS09185	COG0741	lytic transglycosylase activity
BWZ20_RS09185	COG1388	LysM domain
BWZ20_RS09195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BWZ20_RS09225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BWZ20_RS09250	COG0529	Catalyzes the synthesis of activated sulfate
BWZ20_RS09255	COG0175	sulfate reduction
BWZ20_RS09265	COG1086	Polysaccharide biosynthesis protein
BWZ20_RS09270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BWZ20_RS09275	COG1083	cytidylyl-transferase
BWZ20_RS09285	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BWZ20_RS09285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWZ20_RS09290	COG2089	acid synthase
BWZ20_RS09310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BWZ20_RS09385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BWZ20_RS09400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BWZ20_RS09455	COG0356	it plays a direct role in the translocation of protons across the membrane
BWZ20_RS09460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BWZ20_RS09465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BWZ20_RS09470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BWZ20_RS09475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BWZ20_RS09480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BWZ20_RS09495	COG0756	dUTP diphosphatase activity
BWZ20_RS09500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BWZ20_RS09525	COG1607	acyl-coa hydrolase
BWZ20_RS09535	COG0758	DNA mediated transformation
BWZ20_RS09535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BWZ20_RS09565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BWZ20_RS09580	COG1196	nuclear chromosome segregation
BWZ20_RS09580	COG0741	lytic transglycosylase activity
BWZ20_RS09580	COG0739	heme binding
BWZ20_RS09585	COG1774	PSP1 C-terminal conserved region
BWZ20_RS09600	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BWZ20_RS09610	COG4172	Belongs to the ABC transporter superfamily
BWZ20_RS09635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BWZ20_RS09640	COG1253	flavin adenine dinucleotide binding
BWZ20_RS09645	COG0113	porphobilinogen synthase activity
BWZ20_RS09655	COG0408	coproporphyrinogen oxidase activity
BWZ20_RS09670	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
BWZ20_RS09675	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BWZ20_RS09680	COG0181	hydroxymethylbilane synthase activity
BWZ20_RS09685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BWZ20_RS09705	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BWZ20_RS09720	COG1981	membrane
BWZ20_RS09725	COG5000	phosphorelay sensor kinase activity
BWZ20_RS09730	COG1024	Enoyl-CoA hydratase
BWZ20_RS09745	COG2207	Transcriptional regulator
BWZ20_RS09750	COG1418	mRNA catabolic process
BWZ20_RS09765	COG0484	heat shock protein binding
BWZ20_RS09770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BWZ20_RS09775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BWZ20_RS09780	COG1121	(ABC) transporter
BWZ20_RS09785	COG0803	Belongs to the bacterial solute-binding protein 9 family
BWZ20_RS09790	COG4771	TonB-dependent receptor
BWZ20_RS09830	COG1999	signal sequence binding
BWZ20_RS09845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWZ20_RS09855	COG3590	peptidase
BWZ20_RS09865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BWZ20_RS09870	COG0516	GMP reductase activity
BWZ20_RS09870	COG0517	IMP dehydrogenase activity
BWZ20_RS09925	COG0629	single-stranded DNA binding
BWZ20_RS09945	COG1528	Iron-storage protein
BWZ20_RS09950	COG0123	including yeast histone deacetylase and acetoin utilization protein
BWZ20_RS09965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWZ20_RS09965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BWZ20_RS09970	COG1619	proteins homologs of microcin C7 resistance protein MccF
BWZ20_RS09975	COG0792	nuclease activity
BWZ20_RS09985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BWZ20_RS09990	COG0194	GDP metabolic process
BWZ20_RS09995	COG1561	YicC-like family, N-terminal region
BWZ20_RS10010	COG0697	spore germination
BWZ20_RS10025	COG0626	cystathionine gamma-synthase activity
BWZ20_RS10035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BWZ20_RS10045	COG1381	Involved in DNA repair and RecF pathway recombination
BWZ20_RS10075	COG2268	Band 7 protein
BWZ20_RS10110	COG3655	Transcriptional regulator
BWZ20_RS10115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BWZ20_RS10120	COG0587	DNA-directed DNA polymerase activity
BWZ20_RS10130	COG0673	inositol 2-dehydrogenase activity
BWZ20_RS10150	COG4206	TonB-dependent receptor
BWZ20_RS10150	COG1629	transport
BWZ20_RS10165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BWZ20_RS10175	COG0297	glycogen (starch) synthase activity
BWZ20_RS10180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BWZ20_RS10185	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BWZ20_RS10205	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BWZ20_RS10210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BWZ20_RS10220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BWZ20_RS10230	COG2204	response regulator
BWZ20_RS10245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BWZ20_RS10255	COG0189	ligase activity
BWZ20_RS10260	COG0189	ligase activity
BWZ20_RS10260	COG4067	protein conserved in archaea
BWZ20_RS10265	COG0322	excinuclease ABC activity
BWZ20_RS10295	COG3185	4-Hydroxyphenylpyruvate dioxygenase
BWZ20_RS10305	COG3483	tryptophan 2,3-dioxygenase activity
BWZ20_RS10315	COG0166	Belongs to the GPI family
BWZ20_RS10320	COG4206	TonB-dependent receptor
BWZ20_RS10320	COG1629	transport
BWZ20_RS10335	COG0629	single-stranded DNA binding
BWZ20_RS10345	COG0776	regulation of translation
BWZ20_RS10350	COG1530	ribonuclease E activity
BWZ20_RS10360	COG0233	cytoplasmic translational termination
BWZ20_RS10365	COG0528	UMP kinase activity
BWZ20_RS10370	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BWZ20_RS10375	COG0052	Belongs to the universal ribosomal protein uS2 family
BWZ20_RS10380	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BWZ20_RS10385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BWZ20_RS10390	COG0009	L-threonylcarbamoyladenylate synthase
BWZ20_RS10395	COG1032	radical SAM domain protein
BWZ20_RS10400	COG0693	protein deglycase activity
BWZ20_RS10405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BWZ20_RS10405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BWZ20_RS10420	COG0745	RESPONSE REGULATOR receiver
BWZ20_RS10420	COG2205	protein histidine kinase activity
BWZ20_RS10420	COG3292	Two component regulator propeller
BWZ20_RS10450	COG1446	asparaginase
BWZ20_RS10460	COG3537	Alpha-1,2-mannosidase
BWZ20_RS10470	COG1408	metallophosphoesterase
BWZ20_RS10475	COG3118	belongs to the thioredoxin family
BWZ20_RS10495	COG0589	response to stress
BWZ20_RS10500	COG0779	Required for maturation of 30S ribosomal subunits
BWZ20_RS10505	COG0195	Participates in both transcription termination and antitermination
BWZ20_RS10510	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BWZ20_RS10525	COG0437	4 iron, 4 sulfur cluster binding
BWZ20_RS10530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BWZ20_RS10530	COG3743	rRNA binding
BWZ20_RS10550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BWZ20_RS10555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BWZ20_RS10560	COG2255	four-way junction helicase activity
BWZ20_RS10565	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BWZ20_RS10570	COG0280	phosphate acetyltransferase
BWZ20_RS10570	COG0281	malic enzyme
BWZ20_RS10575	COG0632	four-way junction helicase activity
BWZ20_RS10585	COG0509	glycine decarboxylation via glycine cleavage system
BWZ20_RS10610	COG0109	protoheme IX farnesyltransferase activity
BWZ20_RS10615	COG1845	cytochrome c oxidase, subunit III
BWZ20_RS10635	COG1999	signal sequence binding
BWZ20_RS10640	COG2322	membrane
BWZ20_RS10650	COG1136	(ABC) transporter
BWZ20_RS10655	COG1136	(ABC) transporter
BWZ20_RS10655	COG0577	efflux transmembrane transporter activity
BWZ20_RS10660	COG0577	efflux transmembrane transporter activity
BWZ20_RS10660	COG1136	(ABC) transporter
BWZ20_RS10665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWZ20_RS10675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BWZ20_RS10685	COG1214	PFAM Peptidase M22, glycoprotease
BWZ20_RS10690	COG0668	transmembrane transport
BWZ20_RS10705	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BWZ20_RS10730	COG2972	Histidine kinase
BWZ20_RS10730	COG0745	RESPONSE REGULATOR receiver
BWZ20_RS10745	COG1428	Deoxynucleoside kinase
BWZ20_RS10765	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BWZ20_RS10785	COG1395	domain, Protein
BWZ20_RS10830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BWZ20_RS10835	COG0740	serine-type endopeptidase activity
BWZ20_RS10840	COG0544	peptidyl-prolyl cis-trans isomerase activity
BWZ20_RS10850	COG0596	Alpha beta hydrolase
BWZ20_RS10855	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BWZ20_RS10865	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BWZ20_RS10875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BWZ20_RS10895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BWZ20_RS10900	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BWZ20_RS10905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BWZ20_RS10910	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BWZ20_RS10930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BWZ20_RS10965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BWZ20_RS10985	COG0745	RESPONSE REGULATOR receiver
BWZ20_RS10985	COG3292	Two component regulator propeller
BWZ20_RS10985	COG3292	Two component regulator propeller
BWZ20_RS10985	COG2205	protein histidine kinase activity
BWZ20_RS10985	COG0745	RESPONSE REGULATOR receiver
BWZ20_RS10985	COG2205	protein histidine kinase activity
BWZ20_RS11060	COG2211	Major facilitator Superfamily
BWZ20_RS11075	COG1609	Transcriptional regulator
BWZ20_RS11095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BWZ20_RS11110	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BWZ20_RS11115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BWZ20_RS11120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BWZ20_RS11135	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BWZ20_RS11140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BWZ20_RS11150	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BWZ20_RS11155	COG2086	electron transfer activity
BWZ20_RS11160	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWZ20_RS11160	COG0022	dehydrogenase e1 component
BWZ20_RS11170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BWZ20_RS11175	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BWZ20_RS11190	COG1428	Deoxynucleoside kinase
BWZ20_RS11245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BWZ20_RS11255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BWZ20_RS11260	COG0527	aspartate kinase activity
BWZ20_RS11260	COG0460	homoserine dehydrogenase
BWZ20_RS11285	COG1131	(ABC) transporter
BWZ20_RS11295	COG1605	Chorismate mutase
BWZ20_RS11295	COG0077	Prephenate dehydratase
BWZ20_RS11300	COG0436	Aminotransferase
BWZ20_RS11305	COG0287	Prephenate dehydrogenase
BWZ20_RS11310	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BWZ20_RS11320	COG1162	GTPase activity
BWZ20_RS11325	COG1490	D-aminoacyl-tRNA deacylase activity
BWZ20_RS11345	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BWZ20_RS11350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BWZ20_RS11355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BWZ20_RS11390	COG0358	DNA primase activity
BWZ20_RS11400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BWZ20_RS11420	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BWZ20_RS11440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BWZ20_RS11445	COG3396	Phenylacetate-CoA oxygenase
BWZ20_RS11450	COG3460	Phenylacetate-CoA oxygenase
BWZ20_RS11455	COG3396	Phenylacetate-CoA oxygenase
BWZ20_RS11460	COG2151	metal-sulfur cluster biosynthetic enzyme
BWZ20_RS11465	COG1024	Enoyl-CoA hydratase
BWZ20_RS11470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BWZ20_RS11475	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWZ20_RS11490	COG0183	Belongs to the thiolase family
BWZ20_RS11495	COG2827	Endonuclease containing a URI domain
BWZ20_RS11500	COG2030	dehydratase
BWZ20_RS11500	COG1012	belongs to the aldehyde dehydrogenase family
BWZ20_RS11515	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWZ20_RS11520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BWZ20_RS11525	COG0022	dehydrogenase e1 component
BWZ20_RS11530	COG1278	Cold shock
BWZ20_RS11535	COG0659	secondary active sulfate transmembrane transporter activity
BWZ20_RS11560	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BWZ20_RS11565	COG1388	LysM domain
BWZ20_RS11565	COG0791	NLP P60 protein
BWZ20_RS11570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BWZ20_RS11630	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BWZ20_RS11640	COG2197	response regulator
BWZ20_RS11660	COG0321	lipoyl(octanoyl) transferase activity
BWZ20_RS11685	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BWZ20_RS11690	COG1629	transport
BWZ20_RS11740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BWZ20_RS11745	COG1960	acyl-CoA dehydrogenase activity
BWZ20_RS11760	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BWZ20_RS11765	COG0811	peptide transport
BWZ20_RS11770	COG0848	biopolymer transport protein
BWZ20_RS11780	COG0285	dihydrofolate synthase activity
BWZ20_RS11795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BWZ20_RS11800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BWZ20_RS11815	COG0295	cytidine deaminase activity
BWZ20_RS11820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BWZ20_RS11825	COG0508	dehydrogenase complex catalyzes the overall conversion of
BWZ20_RS11835	COG1028	Short-chain dehydrogenase reductase Sdr
BWZ20_RS11865	COG1127	ABC transporter
BWZ20_RS11870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BWZ20_RS11875	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
BWZ20_RS11895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BWZ20_RS11900	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BWZ20_RS11900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BWZ20_RS11930	COG1510	regulation of RNA biosynthetic process
BWZ20_RS11945	COG0339	signal peptide processing
BWZ20_RS11950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BWZ20_RS11955	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BWZ20_RS11960	COG0563	adenylate kinase activity
BWZ20_RS11970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BWZ20_RS12000	COG2274	protein secretion by the type I secretion system
BWZ20_RS12015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BWZ20_RS12065	COG2003	Belongs to the UPF0758 family
BWZ20_RS12075	COG1011	Hydrolase
BWZ20_RS12085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BWZ20_RS12095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BWZ20_RS12110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BWZ20_RS12115	COG0049	tRNA binding
BWZ20_RS12120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BWZ20_RS12125	COG0051	transcription antitermination factor activity, RNA binding
BWZ20_RS12130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BWZ20_RS12135	COG0088	Forms part of the polypeptide exit tunnel
BWZ20_RS12140	COG0089	rRNA binding
BWZ20_RS12145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BWZ20_RS12150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BWZ20_RS12155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BWZ20_RS12160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BWZ20_RS12165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BWZ20_RS12170	COG0255	Belongs to the universal ribosomal protein uL29 family
BWZ20_RS12175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BWZ20_RS12180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BWZ20_RS12185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BWZ20_RS12190	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BWZ20_RS12195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BWZ20_RS12200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BWZ20_RS12205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BWZ20_RS12210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BWZ20_RS12215	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BWZ20_RS12220	COG1841	ribosomal large subunit assembly
BWZ20_RS12225	COG0200	Binds to the 23S rRNA
BWZ20_RS12235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BWZ20_RS12240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BWZ20_RS12245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BWZ20_RS12250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BWZ20_RS12255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BWZ20_RS12260	COG0202	RNA polymerase activity
BWZ20_RS12265	COG0203	ribosomal protein L17
BWZ20_RS12270	COG0505	Belongs to the CarA family
BWZ20_RS12275	COG0148	phosphopyruvate hydratase activity
BWZ20_RS12295	COG0688	phosphatidylethanolamine metabolic process
BWZ20_RS12300	COG4589	Belongs to the CDS family
BWZ20_RS12310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BWZ20_RS12315	COG0799	negative regulation of ribosome biogenesis
BWZ20_RS12330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BWZ20_RS12350	COG1181	Belongs to the D-alanine--D-alanine ligase family
BWZ20_RS12385	COG0018	arginyl-trna synthetase
BWZ20_RS12395	COG2318	DinB family
BWZ20_RS12410	COG3712	iron ion homeostasis
BWZ20_RS12425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BWZ20_RS12430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BWZ20_RS12445	COG1187	pseudouridine synthase activity
BWZ20_RS12460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BWZ20_RS12460	COG0662	Cupin 2, conserved barrel domain protein
BWZ20_RS12470	COG0433	COG0433 Predicted ATPase
BWZ20_RS12475	COG0602	queuosine metabolic process
BWZ20_RS12490	COG0367	asparagine synthase
BWZ20_RS12495	COG0187	DNA topoisomerase II activity
BWZ20_RS12520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BWZ20_RS12520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BWZ20_RS12535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BWZ20_RS12540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BWZ20_RS12545	COG0215	cysteine-tRNA ligase activity
BWZ20_RS12550	COG0302	gtp cyclohydrolase
BWZ20_RS12575	COG0442	prolyl-tRNA aminoacylation
BWZ20_RS12585	COG0268	Binds directly to 16S ribosomal RNA
BWZ20_RS12605	COG0101	tRNA pseudouridine synthase activity
BWZ20_RS12610	COG1132	(ABC) transporter
BWZ20_RS12635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BWZ20_RS12660	COG0149	triose-phosphate isomerase activity
BWZ20_RS12665	COG2264	protein methyltransferase activity
BWZ20_RS12685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BWZ20_RS12725	COG2356	endonuclease I
BWZ20_RS12745	COG0174	glutamine synthetase
BWZ20_RS12760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BWZ20_RS12785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BWZ20_RS12790	COG0681	Belongs to the peptidase S26 family
BWZ20_RS12795	COG0284	orotidine-5'-phosphate decarboxylase activity
BWZ20_RS12800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BWZ20_RS12830	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BWZ20_RS12830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BWZ20_RS12830	COG1703	isobutyryl-CoA mutase activity
BWZ20_RS12840	COG1522	sequence-specific DNA binding
BWZ20_RS12850	COG0492	ferredoxin-NADP+ reductase activity
BWZ20_RS12865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BWZ20_RS12900	COG2197	response regulator
BWZ20_RS12905	COG4585	Histidine kinase
BWZ20_RS12925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BWZ20_RS12945	COG1090	epimerase
BWZ20_RS12960	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BWZ20_RS12970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BWZ20_RS12975	COG0484	heat shock protein binding
BWZ20_RS12980	COG4152	abc transporter atp-binding protein
BWZ20_RS12985	COG1668	transmembrane transport
BWZ20_RS12990	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BWZ20_RS12990	COG3264	Mechanosensitive ion channel
BWZ20_RS13005	COG2326	polyphosphate kinase activity
BWZ20_RS13015	COG0019	diaminopimelate decarboxylase activity
BWZ20_RS13025	COG0045	succinate-CoA ligase (ADP-forming) activity
BWZ20_RS13030	COG0175	sulfate reduction
BWZ20_RS13050	COG0556	nucleotide-excision repair
BWZ20_RS13090	COG1131	(ABC) transporter
BWZ20_RS13100	COG1612	heme a metabolic process
BWZ20_RS13105	COG0617	tRNA 3'-terminal CCA addition
BWZ20_RS13125	COG0463	Glycosyl transferase, family 2
BWZ20_RS13130	COG1216	Glycosyl transferase, family 2
BWZ20_RS13135	COG0463	Glycosyl transferase, family 2
BWZ20_RS13150	COG2171	N-acyltransferase activity
BWZ20_RS13155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BWZ20_RS13160	COG0242	peptide deformylase activity
BWZ20_RS13170	COG3956	TIGRFAM MazG family protein
BWZ20_RS13180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BWZ20_RS13200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BWZ20_RS13215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BWZ20_RS13235	COG0501	Belongs to the peptidase M48B family
BWZ20_RS13240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BWZ20_RS13255	COG1228	amidohydrolase
BWZ20_RS13260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BWZ20_RS13270	COG2195	Cleaves the N-terminal amino acid of tripeptides
BWZ20_RS13275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BWZ20_RS13285	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BWZ20_RS13290	COG0105	UTP biosynthetic process
BWZ20_RS13310	COG3275	phosphorelay sensor kinase activity
BWZ20_RS13325	COG0402	S-adenosylhomocysteine deaminase activity
BWZ20_RS13335	COG3279	Response regulator of the LytR AlgR family
BWZ20_RS13360	COG4206	TonB-dependent receptor
BWZ20_RS13390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BWZ20_RS13400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BWZ20_RS13415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BWZ20_RS13445	COG0681	Belongs to the peptidase S26 family
BWZ20_RS13450	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BWZ20_RS13460	COG1475	DNA binding
BWZ20_RS13465	COG1192	Involved in chromosome partitioning
BWZ20_RS13470	COG0612	Peptidase, M16
BWZ20_RS13475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BWZ20_RS13475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BWZ20_RS13480	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BWZ20_RS13480	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BWZ20_RS13495	COG2010	Cytochrome c
BWZ20_RS13500	COG2133	pyrroloquinoline quinone binding
BWZ20_RS13595	COG0714	Associated with various cellular activities
BWZ20_RS13630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BWZ20_RS13655	COG1252	NADH dehydrogenase
BWZ20_RS13675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BWZ20_RS13700	COG1132	(ABC) transporter
BWZ20_RS13710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BWZ20_RS13720	COG1862	Preprotein translocase
BWZ20_RS13755	COG2195	Cleaves the N-terminal amino acid of tripeptides
BWZ20_RS13765	COG0167	dihydroorotate dehydrogenase activity
BWZ20_RS13785	COG0517	IMP dehydrogenase activity
BWZ20_RS13785	COG0516	GMP reductase activity
BWZ20_RS13820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BWZ20_RS13825	COG0589	response to stress
BWZ20_RS13850	COG2010	Cytochrome c
BWZ20_RS13875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BWZ20_RS13905	COG3275	phosphorelay sensor kinase activity
BWZ20_RS13910	COG3279	Response regulator of the LytR AlgR family
BWZ20_RS13930	COG2234	aminopeptidase activity
BWZ20_RS13945	COG1960	acyl-CoA dehydrogenase activity
BWZ20_RS13955	COG0183	Belongs to the thiolase family
BWZ20_RS13965	COG1024	Enoyl-CoA hydratase
BWZ20_RS13965	COG1250	3-hydroxyacyl-CoA dehydrogenase
BWZ20_RS13970	COG1846	Transcriptional regulator
BWZ20_RS13980	COG0047	phosphoribosylformylglycinamidine synthase activity
BWZ20_RS13980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BWZ20_RS13990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BWZ20_RS13990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BWZ20_RS13995	COG1595	DNA-templated transcription, initiation
BWZ20_RS14035	COG1132	(ABC) transporter
BWZ20_RS14040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BWZ20_RS14055	COG0254	rRNA binding
BWZ20_RS14080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BWZ20_RS14105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BWZ20_RS14115	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BWZ20_RS14120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BWZ20_RS14130	COG1607	acyl-coa hydrolase
BWZ20_RS14155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BWZ20_RS14165	COG4206	TonB-dependent receptor
BWZ20_RS14185	COG4640	response to antibiotic
BWZ20_RS14200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BWZ20_RS14220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BWZ20_RS14240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BWZ20_RS14250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BWZ20_RS14265	COG1295	ribonuclease BN
BWZ20_RS14275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BWZ20_RS14280	COG3279	Response regulator of the LytR AlgR family
BWZ20_RS14285	COG0360	Binds together with S18 to 16S ribosomal RNA
BWZ20_RS14290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BWZ20_RS14295	COG0359	binds to the 23S rRNA
BWZ20_RS14300	COG0584	glycerophosphoryl diester phosphodiesterase
BWZ20_RS14310	COG0577	efflux transmembrane transporter activity
BWZ20_RS14315	COG0124	histidyl-tRNA synthetase
BWZ20_RS14335	COG1629	transport
BWZ20_RS14340	COG0702	epimerase
BWZ20_RS14350	COG3119	arylsulfatase activity
BWZ20_RS14385	COG3250	beta-galactosidase activity
BWZ20_RS14395	COG3119	arylsulfatase activity
BWZ20_RS14410	COG2814	Major facilitator Superfamily
BWZ20_RS14410	COG0477	Major facilitator Superfamily
BWZ20_RS14440	COG1678	Uncharacterized ACR, COG1678
BWZ20_RS14450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BWZ20_RS14455	COG0514	ATP-dependent DNA helicase (RecQ)
BWZ20_RS14475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BWZ20_RS14495	COG0415	Belongs to the DNA photolyase family
BWZ20_RS14510	COG0386	Belongs to the glutathione peroxidase family
BWZ20_RS14515	COG1028	Short-chain dehydrogenase reductase Sdr
BWZ20_RS14525	COG0302	gtp cyclohydrolase
BWZ20_RS14540	COG0415	Belongs to the DNA photolyase family
BWZ20_RS14545	COG3046	protein related to deoxyribodipyrimidine photolyase
BWZ20_RS14550	COG0415	Belongs to the DNA photolyase family
BWZ20_RS14560	COG0702	epimerase
BWZ20_RS14580	COG0798	PFAM Bile acid sodium symporter
BWZ20_RS14625	COG0598	Magnesium transport protein CorA
BWZ20_RS14640	COG0424	maF-like protein
BWZ20_RS14675	COG1970	mechanosensitive ion channel activity
BWZ20_RS14680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BWZ20_RS14680	COG1333	cytochrome c biogenesis protein
BWZ20_RS14690	COG0534	Mate efflux family protein
BWZ20_RS14705	COG0626	cystathionine gamma-synthase activity
BWZ20_RS14715	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BWZ20_RS14720	COG0490	domain, Protein
BWZ20_RS14720	COG0471	metal ion transport
BWZ20_RS14725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BWZ20_RS14740	COG2234	aminopeptidase activity
BWZ20_RS14745	COG2234	aminopeptidase activity
BWZ20_RS14765	COG0778	Nitroreductase
BWZ20_RS14770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BWZ20_RS14780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BWZ20_RS14780	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BWZ20_RS14795	COG1674	ftsk spoiiie
BWZ20_RS14810	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BWZ20_RS14840	COG2031	fatty acid transporter
BWZ20_RS14850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BWZ20_RS14870	COG0069	glutamate synthase activity
BWZ20_RS14890	COG0009	L-threonylcarbamoyladenylate synthase
BWZ20_RS14895	COG2814	Major facilitator Superfamily
BWZ20_RS14910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BWZ20_RS14915	COG0302	gtp cyclohydrolase
BWZ20_RS14930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BWZ20_RS14935	COG0439	Biotin carboxylase
BWZ20_RS14940	COG0511	ligase activity, forming carbon-carbon bonds
BWZ20_RS14945	COG2339	peptidase activity
BWZ20_RS14950	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BWZ20_RS14955	COG1363	Peptidase, m42
BWZ20_RS14965	COG1272	protein, Hemolysin III