locus-tag	class	description
WPG_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WPG_RS00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WPG_RS00035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WPG_RS00045	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WPG_RS00050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WPG_RS00090	COG0402	S-adenosylhomocysteine deaminase activity
WPG_RS00105	COG3275	phosphorelay sensor kinase activity
WPG_RS00125	COG0105	UTP biosynthetic process
WPG_RS00130	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WPG_RS00140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WPG_RS00150	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WPG_RS00155	COG0500	methyltransferase
WPG_RS00160	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
WPG_RS00165	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WPG_RS00185	COG1233	COG1233 Phytoene dehydrogenase and related
WPG_RS00200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WPG_RS00215	COG0714	Associated with various cellular activities
WPG_RS00220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WPG_RS00230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WPG_RS00250	COG0516	GMP reductase activity
WPG_RS00250	COG0517	IMP dehydrogenase activity
WPG_RS00310	COG0167	dihydroorotate dehydrogenase activity
WPG_RS00315	COG2195	Cleaves the N-terminal amino acid of tripeptides
WPG_RS00330	COG1862	Preprotein translocase
WPG_RS00340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WPG_RS00350	COG1132	(ABC) transporter
WPG_RS00365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WPG_RS00380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WPG_RS00395	COG1252	NADH dehydrogenase
WPG_RS00425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WPG_RS00465	COG0714	Associated with various cellular activities
WPG_RS00565	COG2133	pyrroloquinoline quinone binding
WPG_RS00585	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WPG_RS00595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WPG_RS00595	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WPG_RS00600	COG1192	Involved in chromosome partitioning
WPG_RS00605	COG1475	DNA binding
WPG_RS00615	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WPG_RS00620	COG0681	Belongs to the peptidase S26 family
WPG_RS00650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WPG_RS00665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WPG_RS00675	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WPG_RS00720	COG1131	(ABC) transporter
WPG_RS00730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WPG_RS00740	COG0514	ATP-dependent DNA helicase (RecQ)
WPG_RS00750	COG0805	protein transport
WPG_RS00760	COG1137	ATPase activity
WPG_RS00770	COG1253	flavin adenine dinucleotide binding
WPG_RS00775	COG1183	phosphatidylcholine synthase activity
WPG_RS00790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WPG_RS00805	COG0438	transferase activity, transferring glycosyl groups
WPG_RS00835	COG1696	Membrane protein involved in D-alanine export
WPG_RS00850	COG2089	acid synthase
WPG_RS00855	COG2755	lipolytic protein G-D-S-L family
WPG_RS00855	COG1083	cytidylyl-transferase
WPG_RS00865	COG1215	transferase activity, transferring glycosyl groups
WPG_RS00875	COG1215	transferase activity, transferring glycosyl groups
WPG_RS00885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WPG_RS00925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WPG_RS00930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WPG_RS00945	COG0488	(ABC) transporter
WPG_RS00955	COG1136	(ABC) transporter
WPG_RS00975	COG0653	protein targeting
WPG_RS00990	COG0564	pseudouridine synthase activity
WPG_RS01040	COG1595	DNA-templated transcription, initiation
WPG_RS01050	COG1703	isobutyryl-CoA mutase activity
WPG_RS01055	COG0463	Glycosyl transferase, family 2
WPG_RS01060	COG3952	Lipid A Biosynthesis
WPG_RS01060	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WPG_RS01070	COG0671	phosphoesterase, PA-phosphatase related
WPG_RS01080	COG0534	Mate efflux family protein
WPG_RS01095	COG0482	sulfurtransferase activity
WPG_RS01105	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
WPG_RS01115	COG0706	membrane insertase activity
WPG_RS01120	COG0504	CTP synthase activity
WPG_RS01135	COG0336	Belongs to the RNA methyltransferase TrmD family
WPG_RS01140	COG0335	large ribosomal subunit rRNA binding
WPG_RS01165	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
WPG_RS01200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WPG_RS01205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WPG_RS01210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WPG_RS01215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WPG_RS01220	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
WPG_RS01240	COG0305	Participates in initiation and elongation during chromosome replication
WPG_RS01245	COG0825	malonyl-CoA metabolic process
WPG_RS01260	COG0343	queuine tRNA-ribosyltransferase activity
WPG_RS01265	COG3959	Transketolase, thiamine diphosphate binding domain
WPG_RS01275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WPG_RS01285	COG2195	Cleaves the N-terminal amino acid of tripeptides
WPG_RS01295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WPG_RS01315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WPG_RS01320	COG0501	Belongs to the peptidase M48B family
WPG_RS01335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WPG_RS01345	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WPG_RS01355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WPG_RS01375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WPG_RS01390	COG3956	TIGRFAM MazG family protein
WPG_RS01400	COG0242	peptide deformylase activity
WPG_RS01405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WPG_RS01410	COG2171	N-acyltransferase activity
WPG_RS01420	COG1216	Glycosyl transferase, family 2
WPG_RS01420	COG0463	Glycosyl transferase, family 2
WPG_RS01425	COG1216	Glycosyl transferase, family 2
WPG_RS01430	COG0463	Glycosyl transferase, family 2
WPG_RS01455	COG0517	IMP dehydrogenase activity
WPG_RS01455	COG0617	tRNA 3'-terminal CCA addition
WPG_RS01455	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WPG_RS01460	COG0456	acetyltransferase
WPG_RS01465	COG1612	heme a metabolic process
WPG_RS01480	COG1131	(ABC) transporter
WPG_RS01530	COG0556	nucleotide-excision repair
WPG_RS01550	COG0045	succinate-CoA ligase (ADP-forming) activity
WPG_RS01560	COG0019	diaminopimelate decarboxylase activity
WPG_RS01575	COG4946	Tricorn protease homolog
WPG_RS01575	COG1506	peptidase
WPG_RS01575	COG0823	Involved in the tonB-independent uptake of proteins
WPG_RS01610	COG2326	polyphosphate kinase activity
WPG_RS01615	COG0655	NAD(P)H dehydrogenase (quinone) activity
WPG_RS01630	COG3264	Mechanosensitive ion channel
WPG_RS01630	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WPG_RS01635	COG1668	transmembrane transport
WPG_RS01640	COG4152	abc transporter atp-binding protein
WPG_RS01645	COG0484	heat shock protein binding
WPG_RS01650	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WPG_RS01670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WPG_RS01680	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WPG_RS01680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WPG_RS01685	COG1090	epimerase
WPG_RS01700	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
WPG_RS01715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WPG_RS01740	COG1522	sequence-specific DNA binding
WPG_RS01755	COG1595	DNA-templated transcription, initiation
WPG_RS01760	COG1703	isobutyryl-CoA mutase activity
WPG_RS01760	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WPG_RS01760	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
WPG_RS01765	COG0788	formyltetrahydrofolate deformylase activity
WPG_RS01780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WPG_RS01785	COG0284	orotidine-5'-phosphate decarboxylase activity
WPG_RS01790	COG0563	adenylate kinase activity
WPG_RS01795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WPG_RS01820	COG0174	glutamine synthetase
WPG_RS01845	COG2356	endonuclease I
WPG_RS01860	COG4206	TonB-dependent receptor
WPG_RS01885	COG1960	acyl-CoA dehydrogenase activity
WPG_RS01900	COG2423	ornithine cyclodeaminase activity
WPG_RS01920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WPG_RS01925	COG2091	lysine biosynthetic process via aminoadipic acid
WPG_RS01930	COG0666	response to abiotic stimulus
WPG_RS02015	COG0730	response to heat
WPG_RS02020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WPG_RS02035	COG2264	protein methyltransferase activity
WPG_RS02040	COG0149	triose-phosphate isomerase activity
WPG_RS02045	COG0601	transmembrane transport
WPG_RS02060	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WPG_RS02085	COG1132	(ABC) transporter
WPG_RS02090	COG0101	tRNA pseudouridine synthase activity
WPG_RS02110	COG0268	Binds directly to 16S ribosomal RNA
WPG_RS02120	COG0442	prolyl-tRNA aminoacylation
WPG_RS02145	COG0302	gtp cyclohydrolase
WPG_RS02150	COG0215	cysteine-tRNA ligase activity
WPG_RS02155	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
WPG_RS02160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WPG_RS02175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WPG_RS02190	COG0039	L-malate dehydrogenase activity
WPG_RS02220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WPG_RS02235	COG0187	DNA topoisomerase II activity
WPG_RS02240	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
WPG_RS02250	COG0367	asparagine synthase
WPG_RS02290	COG0602	queuosine metabolic process
WPG_RS02295	COG0251	oxidation-reduction process
WPG_RS02300	COG0433	COG0433 Predicted ATPase
WPG_RS02310	COG0662	Cupin 2, conserved barrel domain protein
WPG_RS02310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WPG_RS02360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WPG_RS02365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WPG_RS02380	COG3712	iron ion homeostasis
WPG_RS02390	COG2318	DinB family
WPG_RS02400	COG0018	arginyl-trna synthetase
WPG_RS02405	COG3867	Arabinogalactan endo-beta-1,4-galactanase
WPG_RS02440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WPG_RS02450	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WPG_RS02450	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WPG_RS02455	COG0799	negative regulation of ribosome biogenesis
WPG_RS02460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WPG_RS02475	COG0688	phosphatidylethanolamine metabolic process
WPG_RS02495	COG0148	phosphopyruvate hydratase activity
WPG_RS02510	COG0203	ribosomal protein L17
WPG_RS02515	COG0202	RNA polymerase activity
WPG_RS02520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WPG_RS02525	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WPG_RS02530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WPG_RS02535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WPG_RS02545	COG0200	Binds to the 23S rRNA
WPG_RS02550	COG1841	ribosomal large subunit assembly
WPG_RS02555	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WPG_RS02560	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WPG_RS02565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WPG_RS02570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WPG_RS02575	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WPG_RS02580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WPG_RS02585	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WPG_RS02590	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WPG_RS02595	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WPG_RS02600	COG0255	Belongs to the universal ribosomal protein uL29 family
WPG_RS02605	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WPG_RS02610	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WPG_RS02615	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WPG_RS02620	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WPG_RS02625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WPG_RS02630	COG0089	rRNA binding
WPG_RS02635	COG0088	Forms part of the polypeptide exit tunnel
WPG_RS02640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WPG_RS02645	COG0051	transcription antitermination factor activity, RNA binding
WPG_RS02650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WPG_RS02655	COG0049	tRNA binding
WPG_RS02660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WPG_RS02670	COG1629	transport
WPG_RS02670	COG4206	TonB-dependent receptor
WPG_RS02680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WPG_RS02690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WPG_RS02705	COG1011	Hydrolase
WPG_RS02715	COG2003	Belongs to the UPF0758 family
WPG_RS02770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WPG_RS02830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WPG_RS02835	COG0563	adenylate kinase activity
WPG_RS02840	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WPG_RS02845	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WPG_RS02850	COG0339	signal peptide processing
WPG_RS02890	COG1090	epimerase
WPG_RS02910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WPG_RS02910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WPG_RS02915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WPG_RS02925	COG1215	transferase activity, transferring glycosyl groups
WPG_RS02935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WPG_RS02940	COG1127	ABC transporter
WPG_RS02960	COG2304	oxidoreductase activity
WPG_RS02980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WPG_RS03005	COG0508	dehydrogenase complex catalyzes the overall conversion of
WPG_RS03015	COG0295	cytidine deaminase activity
WPG_RS03030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WPG_RS03035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WPG_RS03050	COG0285	dihydrofolate synthase activity
WPG_RS03060	COG0848	biopolymer transport protein
WPG_RS03065	COG0811	peptide transport
WPG_RS03085	COG1960	acyl-CoA dehydrogenase activity
WPG_RS03090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WPG_RS03135	COG1629	transport
WPG_RS03140	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WPG_RS03165	COG0321	lipoyl(octanoyl) transferase activity
WPG_RS03195	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WPG_RS03260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WPG_RS03265	COG1388	LysM domain
WPG_RS03265	COG0791	NLP P60 protein
WPG_RS03270	COG2515	1-aminocyclopropane-1-carboxylate deaminase
WPG_RS03280	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WPG_RS03290	COG0659	secondary active sulfate transmembrane transporter activity
WPG_RS03295	COG1278	Cold shock
WPG_RS03300	COG3781	membrane
WPG_RS03305	COG0022	dehydrogenase e1 component
WPG_RS03310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WPG_RS03315	COG0508	dehydrogenase complex catalyzes the overall conversion of
WPG_RS03335	COG1012	belongs to the aldehyde dehydrogenase family
WPG_RS03335	COG2030	dehydratase
WPG_RS03340	COG0183	Belongs to the thiolase family
WPG_RS03350	COG1250	3-hydroxyacyl-CoA dehydrogenase
WPG_RS03355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WPG_RS03360	COG1024	Enoyl-CoA hydratase
WPG_RS03365	COG2151	metal-sulfur cluster biosynthetic enzyme
WPG_RS03370	COG3396	Phenylacetate-CoA oxygenase
WPG_RS03375	COG3460	Phenylacetate-CoA oxygenase
WPG_RS03380	COG3396	Phenylacetate-CoA oxygenase
WPG_RS03385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WPG_RS03395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WPG_RS03430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WPG_RS03435	COG2197	response regulator
WPG_RS03440	COG0358	DNA primase activity
WPG_RS03470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WPG_RS03475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WPG_RS03480	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WPG_RS03505	COG1490	D-aminoacyl-tRNA deacylase activity
WPG_RS03510	COG1162	GTPase activity
WPG_RS03525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WPG_RS03545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
WPG_RS03550	COG0287	Prephenate dehydrogenase
WPG_RS03555	COG0436	Aminotransferase
WPG_RS03565	COG1131	(ABC) transporter
WPG_RS03580	COG0633	Ferredoxin
WPG_RS03585	COG0492	ferredoxin-NADP+ reductase activity
WPG_RS03590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WPG_RS03590	COG1648	precorrin-2 dehydrogenase activity
WPG_RS03600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WPG_RS03615	COG1959	2 iron, 2 sulfur cluster binding
WPG_RS03630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WPG_RS03690	COG1428	Deoxynucleoside kinase
WPG_RS03715	COG3420	alginic acid biosynthetic process
WPG_RS03720	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
WPG_RS03745	COG0508	dehydrogenase complex catalyzes the overall conversion of
WPG_RS03745	COG0022	dehydrogenase e1 component
WPG_RS03750	COG2086	electron transfer activity
WPG_RS03755	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
WPG_RS03765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WPG_RS03770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WPG_RS03780	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
WPG_RS03800	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
WPG_RS03805	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WPG_RS03810	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WPG_RS03815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WPG_RS03840	COG1331	Highly conserved protein containing a thioredoxin domain
WPG_RS03865	COG2211	Major facilitator Superfamily
WPG_RS03905	COG0702	epimerase
WPG_RS03910	COG4771	TonB-dependent receptor
WPG_RS03950	COG2146	nitrite reductase [NAD(P)H] activity
WPG_RS03950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WPG_RS03955	COG2192	nodulation
WPG_RS03970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WPG_RS03985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WPG_RS04005	COG0438	transferase activity, transferring glycosyl groups
WPG_RS04010	COG2244	polysaccharide biosynthetic process
WPG_RS04015	COG2089	acid synthase
WPG_RS04055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WPG_RS04060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WPG_RS04065	COG1086	Polysaccharide biosynthesis protein
WPG_RS04070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WPG_RS04085	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WPG_RS04100	COG1428	Deoxynucleoside kinase
WPG_RS04115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WPG_RS04120	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WPG_RS04140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WPG_RS04145	COG0740	serine-type endopeptidase activity
WPG_RS04150	COG0544	peptidyl-prolyl cis-trans isomerase activity
WPG_RS04155	COG1950	PFAM Membrane protein of
WPG_RS04165	COG0596	Alpha beta hydrolase
WPG_RS04170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WPG_RS04180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WPG_RS04190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WPG_RS04210	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WPG_RS04220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WPG_RS04230	COG3275	phosphorelay sensor kinase activity
WPG_RS04255	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WPG_RS04265	COG0668	transmembrane transport
WPG_RS04270	COG1214	PFAM Peptidase M22, glycoprotease
WPG_RS04275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WPG_RS04285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WPG_RS04290	COG1136	(ABC) transporter
WPG_RS04290	COG0577	efflux transmembrane transporter activity
WPG_RS04295	COG0577	efflux transmembrane transporter activity
WPG_RS04295	COG1136	(ABC) transporter
WPG_RS04300	COG1136	(ABC) transporter
WPG_RS04310	COG2322	membrane
WPG_RS04315	COG1999	signal sequence binding
WPG_RS04335	COG1845	cytochrome c oxidase, subunit III
WPG_RS04340	COG0109	protoheme IX farnesyltransferase activity
WPG_RS04370	COG0509	glycine decarboxylation via glycine cleavage system
WPG_RS04380	COG0632	four-way junction helicase activity
WPG_RS04385	COG0280	phosphate acetyltransferase
WPG_RS04385	COG0281	malic enzyme
WPG_RS04395	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WPG_RS04400	COG1858	cytochrome C peroxidase
WPG_RS04405	COG2255	four-way junction helicase activity
WPG_RS04410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WPG_RS04415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WPG_RS04440	COG0437	4 iron, 4 sulfur cluster binding
WPG_RS04460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WPG_RS04465	COG0195	Participates in both transcription termination and antitermination
WPG_RS04465	COG2251	uridine kinase activity
WPG_RS04470	COG0779	Required for maturation of 30S ribosomal subunits
WPG_RS04475	COG0589	response to stress
WPG_RS04490	COG0726	polysaccharide deacetylase
WPG_RS04495	COG3118	belongs to the thioredoxin family
WPG_RS04500	COG1408	metallophosphoesterase
WPG_RS04510	COG3142	Participates in the control of copper homeostasis
WPG_RS04515	COG3525	Glycosyl hydrolase, family 20, catalytic domain
WPG_RS04525	COG3537	Alpha-1,2-mannosidase
WPG_RS04535	COG1446	asparaginase
WPG_RS04545	COG4585	Histidine kinase
WPG_RS04550	COG0745	RESPONSE REGULATOR receiver
WPG_RS04575	COG0189	ligase activity
WPG_RS04575	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WPG_RS04595	COG3292	Two component regulator propeller
WPG_RS04595	COG2205	protein histidine kinase activity
WPG_RS04595	COG0745	RESPONSE REGULATOR receiver
WPG_RS04655	COG0009	L-threonylcarbamoyladenylate synthase
WPG_RS04675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WPG_RS04705	COG2813	Specifically methylates the guanine in position
WPG_RS04735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WPG_RS04740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WPG_RS04745	COG0052	Belongs to the universal ribosomal protein uS2 family
WPG_RS04750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WPG_RS04755	COG0528	UMP kinase activity
WPG_RS04760	COG0233	cytoplasmic translational termination
WPG_RS04775	COG0017	Asparaginyl-tRNA synthetase
WPG_RS04780	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WPG_RS04810	COG0811	peptide transport
WPG_RS04820	COG0252	asparaginase activity
WPG_RS04825	COG0084	hydrolase, TatD family'
WPG_RS04835	COG2197	response regulator
WPG_RS04840	COG0508	dehydrogenase complex catalyzes the overall conversion of
WPG_RS04845	COG0567	Dehydrogenase, E1 component
WPG_RS04860	COG0142	geranyltranstransferase activity
WPG_RS04865	COG1309	transcriptional regulator
WPG_RS04880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WPG_RS04885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WPG_RS04905	COG0590	tRNA wobble adenosine to inosine editing
WPG_RS04920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WPG_RS04925	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WPG_RS04930	COG4771	TonB-dependent receptor
WPG_RS04960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WPG_RS04970	COG3279	Response regulator of the LytR AlgR family
WPG_RS04975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WPG_RS04980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WPG_RS04980	COG1328	CTP reductase activity
WPG_RS05020	COG2095	MarC family integral membrane protein
WPG_RS05035	COG0793	Belongs to the peptidase S41A family
WPG_RS05050	COG1410	methionine synthase
WPG_RS05050	COG0646	methionine synthase
WPG_RS05055	COG2329	Antibiotic biosynthesis monooxygenase
WPG_RS05065	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
WPG_RS05120	COG0800	Aldolase
WPG_RS05130	COG1609	Transcriptional regulator
WPG_RS05145	COG2186	Transcriptional regulator
WPG_RS05185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WPG_RS05190	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WPG_RS05195	COG0193	aminoacyl-tRNA hydrolase activity
WPG_RS05200	COG0196	riboflavin kinase activity
WPG_RS05210	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WPG_RS05225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WPG_RS05230	COG2239	Acts as a magnesium transporter
WPG_RS05245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WPG_RS05295	COG0527	aspartate kinase activity
WPG_RS05305	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WPG_RS05315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WPG_RS05340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WPG_RS05365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WPG_RS05385	COG0659	secondary active sulfate transmembrane transporter activity
WPG_RS05420	COG2304	oxidoreductase activity
WPG_RS05425	COG2304	oxidoreductase activity
WPG_RS05440	COG0714	Associated with various cellular activities
WPG_RS05450	COG4989	oxidoreductase activity
WPG_RS05455	COG4221	oxidoreductase activity
WPG_RS05500	COG1012	belongs to the aldehyde dehydrogenase family
WPG_RS05505	COG1446	asparaginase
WPG_RS05515	COG4447	cellulose binding
WPG_RS05545	COG2329	Antibiotic biosynthesis monooxygenase
WPG_RS05605	COG0612	Peptidase, M16
WPG_RS05610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WPG_RS05615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WPG_RS05620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WPG_RS05625	COG2234	aminopeptidase activity
WPG_RS05630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WPG_RS05635	COG1053	succinate dehydrogenase
WPG_RS05670	COG0006	proline dipeptidase activity
WPG_RS05680	COG1114	Component of the transport system for branched-chain amino acids
WPG_RS05690	COG2267	carboxylic ester hydrolase activity
WPG_RS05700	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WPG_RS05715	COG0316	Belongs to the HesB IscA family
WPG_RS05720	COG0719	Fe-S assembly protein
WPG_RS05730	COG0396	ATPase activity
WPG_RS05735	COG0719	Fe-S assembly protein
WPG_RS05740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WPG_RS05750	COG2166	iron-sulfur cluster assembly
WPG_RS05755	COG2151	metal-sulfur cluster biosynthetic enzyme
WPG_RS05770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WPG_RS05800	COG2954	triphosphatase activity
WPG_RS05805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WPG_RS05815	COG0469	pyruvate kinase activity
WPG_RS05825	COG0571	ribonuclease III activity
WPG_RS05830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WPG_RS05835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WPG_RS05845	COG0328	RNA-DNA hybrid ribonuclease activity
WPG_RS05845	COG3341	Caulimovirus viroplasmin
WPG_RS05860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WPG_RS05865	COG1074	ATP-dependent DNA helicase activity
WPG_RS05905	COG0720	synthase
WPG_RS05910	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WPG_RS05915	COG3119	arylsulfatase activity
WPG_RS05935	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
WPG_RS05935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WPG_RS05945	COG1765	OsmC-like protein
WPG_RS05955	COG1573	uracil-dna glycosylase
WPG_RS05960	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WPG_RS05975	COG1435	thymidine kinase activity
WPG_RS05980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WPG_RS05985	COG1970	mechanosensitive ion channel activity
WPG_RS05990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WPG_RS05995	COG1505	serine-type exopeptidase activity
WPG_RS06015	COG3842	ATPase activity
WPG_RS06030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WPG_RS06035	COG4935	Belongs to the peptidase S8 family
WPG_RS06035	COG2234	aminopeptidase activity
WPG_RS06040	COG0439	Biotin carboxylase
WPG_RS06045	COG0511	ligase activity, forming carbon-carbon bonds
WPG_RS06050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WPG_RS06055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WPG_RS06065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WPG_RS06090	COG3604	Transcriptional regulator
WPG_RS06130	COG3525	Glycosyl hydrolase, family 20, catalytic domain
WPG_RS06140	COG0363	glucosamine-6-phosphate deaminase activity
WPG_RS06150	COG1629	transport
WPG_RS06150	COG4206	TonB-dependent receptor
WPG_RS06155	COG3275	phosphorelay sensor kinase activity
WPG_RS06160	COG3279	Response regulator of the LytR AlgR family
WPG_RS06185	COG0346	lactoylglutathione lyase activity
WPG_RS06190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WPG_RS06195	COG4591	ABC-type transport system involved in lipoprotein release permease component
WPG_RS06200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WPG_RS06225	COG0481	GTPase activity
WPG_RS06235	COG2197	response regulator
WPG_RS06255	COG3263	regulation of cellular component size
WPG_RS06260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WPG_RS06275	COG0594	ribonuclease P activity
WPG_RS06280	COG0793	Belongs to the peptidase S41A family
WPG_RS06290	COG2153	protein acetylation
WPG_RS06295	COG0698	ribose 5-phosphate isomerase
WPG_RS06315	COG0557	exoribonuclease II activity
WPG_RS06320	COG0393	Putative heavy-metal-binding
WPG_RS06360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WPG_RS06385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WPG_RS06390	COG3239	Fatty acid desaturase
WPG_RS06400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WPG_RS06405	COG0445	tRNA wobble uridine modification
WPG_RS06420	COG0470	DNA polymerase III
WPG_RS06425	COG0126	phosphoglycerate kinase activity
WPG_RS06430	COG1388	LysM domain
WPG_RS06430	COG0741	lytic transglycosylase activity
WPG_RS06440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WPG_RS06490	COG3551	Protein conserved in bacteria
WPG_RS06545	COG1215	transferase activity, transferring glycosyl groups
WPG_RS06555	COG0151	Belongs to the GarS family
WPG_RS06570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WPG_RS06585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WPG_RS06640	COG0356	it plays a direct role in the translocation of protons across the membrane
WPG_RS06645	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WPG_RS06650	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WPG_RS06655	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WPG_RS06660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WPG_RS06665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WPG_RS06685	COG0756	dUTP diphosphatase activity
WPG_RS06690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WPG_RS06715	COG1607	acyl-coa hydrolase
WPG_RS06725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WPG_RS06725	COG0758	DNA mediated transformation
WPG_RS06730	COG0180	Tryptophanyl-tRNA synthetase
WPG_RS06755	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WPG_RS06770	COG1774	PSP1 C-terminal conserved region
WPG_RS06780	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WPG_RS06785	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WPG_RS06845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WPG_RS06850	COG1253	flavin adenine dinucleotide binding
WPG_RS06890	COG0113	porphobilinogen synthase activity
WPG_RS06905	COG0408	coproporphyrinogen oxidase activity
WPG_RS06930	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WPG_RS06940	COG0181	hydroxymethylbilane synthase activity
WPG_RS06945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WPG_RS06965	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WPG_RS06980	COG1981	membrane
WPG_RS06990	COG1024	Enoyl-CoA hydratase
WPG_RS06995	COG0673	inositol 2-dehydrogenase activity
WPG_RS07010	COG2207	Transcriptional regulator
WPG_RS07015	COG1418	mRNA catabolic process
WPG_RS07035	COG0484	heat shock protein binding
WPG_RS07050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WPG_RS07055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WPG_RS07065	COG1121	(ABC) transporter
WPG_RS07070	COG0803	Belongs to the bacterial solute-binding protein 9 family
WPG_RS07075	COG4771	TonB-dependent receptor
WPG_RS07100	COG1999	signal sequence binding
WPG_RS07130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WPG_RS07140	COG3590	peptidase
WPG_RS07155	COG0516	GMP reductase activity
WPG_RS07155	COG0517	IMP dehydrogenase activity
WPG_RS07170	COG0629	single-stranded DNA binding
WPG_RS07195	COG1528	Iron-storage protein
WPG_RS07220	COG1690	Belongs to the RtcB family
WPG_RS07230	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WPG_RS07380	COG0123	including yeast histone deacetylase and acetoin utilization protein
WPG_RS07390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WPG_RS07390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WPG_RS07405	COG1619	proteins homologs of microcin C7 resistance protein MccF
WPG_RS07415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WPG_RS07425	COG0792	nuclease activity
WPG_RS07430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WPG_RS07435	COG0194	GDP metabolic process
WPG_RS07440	COG1561	YicC-like family, N-terminal region
WPG_RS07480	COG0626	cystathionine gamma-synthase activity
WPG_RS07490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WPG_RS07500	COG1381	Involved in DNA repair and RecF pathway recombination
WPG_RS07530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WPG_RS07540	COG2268	Band 7 protein
WPG_RS07560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WPG_RS07565	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WPG_RS07600	COG3655	Transcriptional regulator
WPG_RS07605	COG2135	peptidase activity
WPG_RS07610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WPG_RS07625	COG3279	Response regulator of the LytR AlgR family
WPG_RS07640	COG0673	inositol 2-dehydrogenase activity
WPG_RS07645	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WPG_RS07660	COG4771	TonB-dependent receptor
WPG_RS07665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WPG_RS07675	COG0297	glycogen (starch) synthase activity
WPG_RS07680	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WPG_RS07685	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
WPG_RS07705	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WPG_RS07720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WPG_RS07730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WPG_RS07735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WPG_RS07745	COG0189	ligase activity
WPG_RS07750	COG0322	excinuclease ABC activity
WPG_RS07755	COG1752	Esterase of the alpha-beta hydrolase superfamily
WPG_RS07760	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WPG_RS07770	COG3185	4-Hydroxyphenylpyruvate dioxygenase
WPG_RS07780	COG3483	tryptophan 2,3-dioxygenase activity
WPG_RS07790	COG0166	Belongs to the GPI family
WPG_RS07795	COG4771	TonB-dependent receptor
WPG_RS07820	COG1194	a g-specific adenine glycosylase
WPG_RS07825	COG0776	regulation of translation
WPG_RS07830	COG1530	ribonuclease E activity
WPG_RS07835	COG0667	Aldo Keto reductase
WPG_RS07845	COG0708	Exodeoxyribonuclease III
WPG_RS07875	COG0423	glycine-tRNA ligase activity
WPG_RS07885	COG1040	competence protein
WPG_RS07895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WPG_RS07905	COG0436	Aminotransferase
WPG_RS07945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WPG_RS07955	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
WPG_RS07980	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WPG_RS07995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WPG_RS08000	COG0537	adenosine 5'-monophosphoramidase activity
WPG_RS08005	COG3852	Histidine kinase
WPG_RS08010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WPG_RS08020	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WPG_RS08035	COG0519	Catalyzes the synthesis of GMP from XMP
WPG_RS08050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WPG_RS08055	COG1968	undecaprenyl-diphosphatase activity
WPG_RS08060	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
WPG_RS08085	COG2177	Part of the ABC transporter FtsEX involved in
WPG_RS08090	COG0495	leucyl-tRNA aminoacylation
WPG_RS08100	COG0686	Belongs to the AlaDH PNT family
WPG_RS08110	COG0697	spore germination
WPG_RS08115	COG1522	sequence-specific DNA binding
WPG_RS08125	COG2363	Small membrane protein
WPG_RS08130	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
WPG_RS08145	COG0463	Glycosyl transferase, family 2
WPG_RS08150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WPG_RS08160	COG1090	epimerase
WPG_RS08165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WPG_RS08185	COG0745	RESPONSE REGULATOR receiver
WPG_RS08190	COG5002	protein histidine kinase activity
WPG_RS08200	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WPG_RS08215	COG0489	protein tyrosine kinase activity
WPG_RS08220	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WPG_RS08225	COG0492	ferredoxin-NADP+ reductase activity
WPG_RS08230	COG0633	Ferredoxin
WPG_RS08250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WPG_RS08255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WPG_RS08260	COG0228	four-way junction DNA binding
WPG_RS08300	COG4585	Histidine kinase
WPG_RS08350	COG0463	Glycosyl transferase, family 2
WPG_RS08365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WPG_RS08375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WPG_RS08395	COG2315	Protein conserved in bacteria
WPG_RS08405	COG0784	Response regulator, receiver
WPG_RS08415	COG4251	negative regulation of phosphorylation
WPG_RS08435	COG3279	Response regulator of the LytR AlgR family
WPG_RS08440	COG0745	RESPONSE REGULATOR receiver
WPG_RS08470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WPG_RS08480	COG0438	transferase activity, transferring glycosyl groups
WPG_RS08490	COG0110	maltose O-acetyltransferase activity
WPG_RS08545	COG1482	cell wall glycoprotein biosynthetic process
WPG_RS08550	COG2824	Alkylphosphonate utilization operon protein PhnA
WPG_RS08585	COG2234	aminopeptidase activity
WPG_RS08615	COG1523	belongs to the glycosyl hydrolase 13 family
WPG_RS08625	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WPG_RS08630	COG4206	TonB-dependent receptor
WPG_RS08630	COG1629	transport
WPG_RS08645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WPG_RS08650	COG1554	hydrolase, family 65, central catalytic
WPG_RS08655	COG0366	Alpha amylase catalytic
WPG_RS08660	COG2819	hydrolase of the alpha beta superfamily
WPG_RS08665	COG1501	Belongs to the glycosyl hydrolase 31 family
WPG_RS08675	COG0366	Alpha amylase catalytic
WPG_RS08695	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WPG_RS08710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WPG_RS08730	COG2081	HI0933 family
WPG_RS08765	COG1187	pseudouridine synthase activity
WPG_RS08770	COG2205	protein histidine kinase activity
WPG_RS08770	COG0784	Response regulator, receiver
WPG_RS08780	COG1629	transport
WPG_RS08825	COG1215	transferase activity, transferring glycosyl groups
WPG_RS08850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WPG_RS08905	COG0463	Glycosyl transferase, family 2
WPG_RS08925	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
WPG_RS08955	COG3608	succinylglutamate desuccinylase aspartoacylase
WPG_RS08955	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
WPG_RS08975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WPG_RS08985	COG0590	tRNA wobble adenosine to inosine editing
WPG_RS08990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WPG_RS08995	COG3938	Belongs to the proline racemase family
WPG_RS09005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WPG_RS09015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WPG_RS09030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WPG_RS09035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WPG_RS09040	COG0066	3-isopropylmalate dehydratase activity
WPG_RS09050	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WPG_RS09055	COG0004	ammonium transporteR
WPG_RS09065	COG0004	ammonium transporteR
WPG_RS09075	COG0069	glutamate synthase activity
WPG_RS09075	COG0067	glutamate synthase
WPG_RS09075	COG0070	glutamate synthase
WPG_RS09085	COG0165	Argininosuccinate lyase
WPG_RS09095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WPG_RS09105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WPG_RS09110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WPG_RS09115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WPG_RS09120	COG0137	argininosuccinate synthase activity
WPG_RS09130	COG1012	belongs to the aldehyde dehydrogenase family
WPG_RS09135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WPG_RS09140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WPG_RS09150	COG0028	Belongs to the TPP enzyme family
WPG_RS09155	COG0129	dihydroxy-acid dehydratase activity
WPG_RS09160	COG0477	Major facilitator Superfamily
WPG_RS09160	COG2814	Major facilitator Superfamily
WPG_RS09175	COG4206	TonB-dependent receptor
WPG_RS09175	COG1629	transport
WPG_RS09210	COG0572	uridine kinase
WPG_RS09230	COG0738	Major facilitator superfamily
WPG_RS09235	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WPG_RS09240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WPG_RS09275	COG2211	Major facilitator Superfamily
WPG_RS09280	COG0673	inositol 2-dehydrogenase activity
WPG_RS09295	COG0366	Alpha amylase catalytic
WPG_RS09300	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WPG_RS09315	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
WPG_RS09360	COG0823	Involved in the tonB-independent uptake of proteins
WPG_RS09360	COG1506	peptidase
WPG_RS09365	COG3104	oligopeptide transport
WPG_RS09370	COG4232	protein-disulfide reductase activity
WPG_RS09375	COG2333	competence protein COMEC
WPG_RS09375	COG0658	competence protein
WPG_RS09380	COG0791	NLP P60 protein
WPG_RS09385	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WPG_RS09395	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WPG_RS09400	COG0793	Belongs to the peptidase S41A family
WPG_RS09405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WPG_RS09410	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WPG_RS09415	COG2267	carboxylic ester hydrolase activity
WPG_RS09420	COG2001	Belongs to the MraZ family
WPG_RS09425	COG0275	rRNA processing
WPG_RS09435	COG0768	penicillin binding
WPG_RS09440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WPG_RS09445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WPG_RS09450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WPG_RS09455	COG0772	Belongs to the SEDS family
WPG_RS09460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WPG_RS09465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WPG_RS09480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WPG_RS09485	COG1610	YqeY-like protein
WPG_RS09520	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
WPG_RS09525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WPG_RS09535	COG0529	Catalyzes the synthesis of activated sulfate
WPG_RS09590	COG1216	Glycosyl transferase, family 2
WPG_RS09615	COG0297	glycogen (starch) synthase activity
WPG_RS09655	COG1216	Glycosyl transferase, family 2
WPG_RS09660	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WPG_RS09670	COG0489	protein tyrosine kinase activity
WPG_RS09675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WPG_RS09680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WPG_RS09700	COG1185	polyribonucleotide nucleotidyltransferase activity
WPG_RS09705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WPG_RS09720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WPG_RS09725	COG0191	fructose-bisphosphate aldolase activity
WPG_RS09745	COG2226	methyltransferase
WPG_RS09750	COG0569	domain protein
WPG_RS09755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WPG_RS09775	COG0436	Aminotransferase
WPG_RS09780	COG3239	Fatty acid desaturase
WPG_RS09785	COG0357	Ribosomal RNA small subunit methyltransferase G
WPG_RS09805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WPG_RS09820	COG1012	belongs to the aldehyde dehydrogenase family
WPG_RS09830	COG2967	ApaG domain
WPG_RS09835	COG0076	glutamate decarboxylase activity
WPG_RS09850	COG1805	sodium ion transport
WPG_RS09855	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WPG_RS09860	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WPG_RS09865	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WPG_RS09880	COG0471	metal ion transport
WPG_RS09895	COG1477	protein flavinylation
WPG_RS09915	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WPG_RS09925	COG0501	Belongs to the peptidase M48B family
WPG_RS09935	COG3340	Belongs to the peptidase S51 family
WPG_RS09960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WPG_RS09980	COG0662	Cupin 2, conserved barrel domain protein
WPG_RS09985	COG1028	Short-chain dehydrogenase reductase Sdr
WPG_RS10025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WPG_RS10030	COG3844	kynureninase activity
WPG_RS10065	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WPG_RS10070	COG1663	tetraacyldisaccharide 4'-kinase activity
WPG_RS10075	COG5002	protein histidine kinase activity
WPG_RS10075	COG0784	Response regulator, receiver
WPG_RS10080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WPG_RS10085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WPG_RS10120	COG1595	DNA-templated transcription, initiation
WPG_RS10125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WPG_RS10130	COG0436	Aminotransferase
WPG_RS10145	COG0525	valine-tRNA ligase activity
WPG_RS10155	COG0772	Belongs to the SEDS family
WPG_RS10160	COG0768	penicillin binding
WPG_RS10175	COG1077	Cell shape determining protein MreB Mrl
WPG_RS10190	COG0138	bifunctional purine biosynthesis protein purh
WPG_RS10240	COG0459	protein refolding
WPG_RS10245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WPG_RS10280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WPG_RS10305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WPG_RS10335	COG0488	(ABC) transporter
WPG_RS10415	COG1595	DNA-templated transcription, initiation
WPG_RS10420	COG0596	Alpha beta hydrolase
WPG_RS10530	COG2205	protein histidine kinase activity
WPG_RS10530	COG0784	Response regulator, receiver
WPG_RS10565	COG3279	Response regulator of the LytR AlgR family
WPG_RS10570	COG3275	phosphorelay sensor kinase activity
WPG_RS10585	COG1136	(ABC) transporter
WPG_RS10590	COG0577	efflux transmembrane transporter activity
WPG_RS10590	COG1136	(ABC) transporter
WPG_RS10620	COG3609	addiction module antidote protein, CC2985 family
WPG_RS10770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WPG_RS10845	COG3421	Type III restriction
WPG_RS10850	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WPG_RS10885	COG4974	Belongs to the 'phage' integrase family
WPG_RS10900	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WPG_RS10910	COG1160	GTP binding
WPG_RS10955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WPG_RS10970	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WPG_RS10975	COG1181	Belongs to the D-alanine--D-alanine ligase family
WPG_RS10985	COG0564	pseudouridine synthase activity
WPG_RS10990	COG3022	response to hydroperoxide
WPG_RS11015	COG0513	Belongs to the DEAD box helicase family
WPG_RS11025	COG4628	conserved protein (DUF2132)
WPG_RS11050	COG0159	tryptophan synthase activity
WPG_RS11055	COG0133	tryptophan synthase activity
WPG_RS11060	COG0135	phosphoribosylanthranilate isomerase activity
WPG_RS11065	COG0134	indole-3-glycerol-phosphate synthase activity
WPG_RS11070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WPG_RS11075	COG0512	Glutamine amidotransferase of anthranilate synthase
WPG_RS11080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WPG_RS11090	COG0386	Belongs to the glutathione peroxidase family
WPG_RS11095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WPG_RS11100	COG1054	Belongs to the UPF0176 family
WPG_RS11120	COG3852	Histidine kinase
WPG_RS11135	COG1136	(ABC) transporter
WPG_RS11140	COG0577	efflux transmembrane transporter activity
WPG_RS11150	COG0577	efflux transmembrane transporter activity
WPG_RS11165	COG0577	efflux transmembrane transporter activity
WPG_RS11180	COG1136	(ABC) transporter
WPG_RS11215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WPG_RS11220	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WPG_RS11255	COG1472	Belongs to the glycosyl hydrolase 3 family
WPG_RS11265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WPG_RS11390	COG3177	Filamentation induced by cAMP protein fic
WPG_RS11400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WPG_RS11465	COG2020	methyltransferase activity
WPG_RS11490	COG3177	Filamentation induced by cAMP protein fic
WPG_RS11580	COG0300	oxidoreductase activity
WPG_RS11605	COG2949	membrane
WPG_RS11645	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WPG_RS11660	COG1217	gtp-binding protein TYPA
WPG_RS11705	COG2244	polysaccharide biosynthetic process
WPG_RS11720	COG0438	transferase activity, transferring glycosyl groups
WPG_RS11740	COG2884	Cell division ATP-binding protein ftsE
WPG_RS11760	COG1574	metal-dependent hydrolase with the TIM-barrel fold
WPG_RS11790	COG0584	glycerophosphoryl diester phosphodiesterase
WPG_RS11800	COG3876	Protein conserved in bacteria
WPG_RS11825	COG2198	Histidine kinase
WPG_RS11825	COG2205	protein histidine kinase activity
WPG_RS11825	COG0784	Response regulator, receiver
WPG_RS11835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WPG_RS11840	COG1115	amino acid carrier protein
WPG_RS11845	COG1555	photosystem II stabilization
WPG_RS11850	COG1960	acyl-CoA dehydrogenase activity
WPG_RS11855	COG4974	Belongs to the 'phage' integrase family
WPG_RS11860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WPG_RS11885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WPG_RS11905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WPG_RS11910	COG0081	regulation of translation
WPG_RS11915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WPG_RS11920	COG0222	ribosome binding
WPG_RS11925	COG0085	RNA polymerase activity
WPG_RS11930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WPG_RS11970	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
WPG_RS11985	COG2885	chlorophyll binding
WPG_RS11990	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WPG_RS12035	COG1073	alpha beta
WPG_RS12065	COG1595	DNA-templated transcription, initiation
WPG_RS12100	COG0513	Belongs to the DEAD box helicase family
WPG_RS12110	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
WPG_RS12115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WPG_RS12120	COG2258	MOSC domain
WPG_RS12140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WPG_RS12155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WPG_RS12165	COG0326	Molecular chaperone. Has ATPase activity
WPG_RS12170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WPG_RS12205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WPG_RS12215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WPG_RS12225	COG0508	dehydrogenase complex catalyzes the overall conversion of
WPG_RS12235	COG0436	Aminotransferase
WPG_RS12255	COG3813	Protein conserved in bacteria
WPG_RS12265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WPG_RS12285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WPG_RS12290	COG0179	Fumarylacetoacetate (FAA) hydrolase
WPG_RS12300	COG1546	Belongs to the CinA family
WPG_RS12300	COG1058	Belongs to the CinA family
WPG_RS12305	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WPG_RS12310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WPG_RS12315	COG0552	protein localization to endoplasmic reticulum
WPG_RS12330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WPG_RS12355	COG0612	Peptidase, M16
WPG_RS12365	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
WPG_RS12390	COG0519	Catalyzes the synthesis of GMP from XMP
WPG_RS12390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WPG_RS12405	COG3530	Putative quorum-sensing-regulated virulence factor
WPG_RS12470	COG1960	acyl-CoA dehydrogenase activity
WPG_RS12475	COG0183	Belongs to the thiolase family
WPG_RS12480	COG1250	3-hydroxyacyl-CoA dehydrogenase
WPG_RS12480	COG1024	Enoyl-CoA hydratase
WPG_RS12485	COG1846	Transcriptional regulator
WPG_RS12500	COG0047	phosphoribosylformylglycinamidine synthase activity
WPG_RS12500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WPG_RS12505	COG2356	endonuclease I
WPG_RS12510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WPG_RS12510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WPG_RS12515	COG1595	DNA-templated transcription, initiation
WPG_RS12580	COG1595	DNA-templated transcription, initiation
WPG_RS12585	COG1132	(ABC) transporter
WPG_RS12590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WPG_RS12595	COG0463	Glycosyl transferase, family 2
WPG_RS12605	COG0254	rRNA binding
WPG_RS12625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WPG_RS12650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WPG_RS12655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WPG_RS12665	COG1607	acyl-coa hydrolase
WPG_RS12680	COG1120	ATPase activity
WPG_RS12685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WPG_RS12695	COG4206	TonB-dependent receptor
WPG_RS12715	COG4640	response to antibiotic
WPG_RS12770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WPG_RS12815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WPG_RS12835	COG0673	inositol 2-dehydrogenase activity
WPG_RS12845	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WPG_RS12855	COG1295	ribonuclease BN
WPG_RS12860	COG3279	Response regulator of the LytR AlgR family
WPG_RS12865	COG3275	phosphorelay sensor kinase activity
WPG_RS12920	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WPG_RS12925	COG3279	Response regulator of the LytR AlgR family
WPG_RS12930	COG0360	Binds together with S18 to 16S ribosomal RNA
WPG_RS12935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WPG_RS12940	COG0359	binds to the 23S rRNA
WPG_RS12945	COG0584	glycerophosphoryl diester phosphodiesterase
WPG_RS12955	COG0577	efflux transmembrane transporter activity
WPG_RS12960	COG0124	histidyl-tRNA synthetase
WPG_RS12985	COG0402	S-adenosylhomocysteine deaminase activity
WPG_RS12990	COG3291	Pkd domain containing protein
WPG_RS13015	COG1678	Uncharacterized ACR, COG1678
WPG_RS13025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WPG_RS13050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WPG_RS13075	COG0415	Belongs to the DNA photolyase family
WPG_RS13095	COG0386	Belongs to the glutathione peroxidase family
WPG_RS13110	COG0302	gtp cyclohydrolase
WPG_RS13125	COG0415	Belongs to the DNA photolyase family
WPG_RS13130	COG3046	protein related to deoxyribodipyrimidine photolyase
WPG_RS13140	COG0415	Belongs to the DNA photolyase family
WPG_RS13145	COG0702	epimerase
WPG_RS13165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WPG_RS13215	COG0424	maF-like protein
WPG_RS13245	COG1970	mechanosensitive ion channel activity
WPG_RS13250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WPG_RS13250	COG1333	cytochrome c biogenesis protein
WPG_RS13265	COG0534	Mate efflux family protein
WPG_RS13275	COG0626	cystathionine gamma-synthase activity
WPG_RS13280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
WPG_RS13290	COG2234	aminopeptidase activity
WPG_RS13295	COG2234	aminopeptidase activity
WPG_RS13325	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WPG_RS13330	COG0778	Nitroreductase
WPG_RS13335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WPG_RS13345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WPG_RS13345	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WPG_RS13360	COG1674	ftsk spoiiie
WPG_RS13420	COG2031	fatty acid transporter
WPG_RS13430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WPG_RS13455	COG0069	glutamate synthase activity
WPG_RS13460	COG1473	amidohydrolase
WPG_RS13495	COG0009	L-threonylcarbamoyladenylate synthase
WPG_RS13500	COG2814	Major facilitator Superfamily
WPG_RS13510	COG1132	(ABC) transporter
WPG_RS13520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WPG_RS13525	COG0439	Biotin carboxylase
WPG_RS13535	COG2339	peptidase activity
WPG_RS13540	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WPG_RS13550	COG1363	Peptidase, m42
WPG_RS13560	COG1272	protein, Hemolysin III
WPG_RS13590	COG1028	Short-chain dehydrogenase reductase Sdr
WPG_RS13595	COG0778	Nitroreductase
WPG_RS13600	COG1733	regulation of RNA biosynthetic process
WPG_RS13655	COG3591	Belongs to the peptidase S1B family
WPG_RS13675	COG0523	cobalamin synthesis protein
WPG_RS13715	COG2226	methyltransferase
WPG_RS13720	COG0116	Belongs to the methyltransferase superfamily
WPG_RS13730	COG3279	Response regulator of the LytR AlgR family
WPG_RS13735	COG2972	Histidine kinase
WPG_RS13795	COG1611	Belongs to the LOG family
WPG_RS13800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WPG_RS13840	COG0793	Belongs to the peptidase S41A family
WPG_RS13840	COG4946	Tricorn protease homolog
WPG_RS13845	COG0405	Gamma-glutamyltransferase
WPG_RS13855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WPG_RS13870	COG1560	Kdo2-lipid A biosynthetic process
WPG_RS13880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WPG_RS13885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WPG_RS13895	COG0592	DNA-directed DNA polymerase activity
WPG_RS13925	COG1702	phosphate starvation-inducible protein PhoH
WPG_RS13930	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WPG_RS13965	COG1595	DNA-templated transcription, initiation
WPG_RS13975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WPG_RS14005	COG1104	cysteine desulfurase activity
WPG_RS14035	COG1418	mRNA catabolic process
WPG_RS14040	COG4974	Belongs to the 'phage' integrase family
WPG_RS14050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WPG_RS14065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WPG_RS14075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WPG_RS14080	COG0297	glycogen (starch) synthase activity
WPG_RS14085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WPG_RS14090	COG0366	Alpha amylase catalytic
WPG_RS14100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WPG_RS14115	COG2270	Major facilitator Superfamily
WPG_RS14145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WPG_RS14150	COG1388	LysM domain
WPG_RS14150	COG1705	Flagellar rod assembly protein muramidase FlgJ
WPG_RS14160	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WPG_RS14165	COG1652	LysM domain
WPG_RS14165	COG2823	Periplasmic or secreted lipoprotein
WPG_RS14185	COG0540	Belongs to the ATCase OTCase family
WPG_RS14195	COG1234	tRNA 3'-trailer cleavage
WPG_RS14205	COG0259	pyridoxamine-phosphate oxidase activity
WPG_RS14240	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WPG_RS14285	COG0742	ribosomal rna small subunit methyltransferase
WPG_RS14300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WPG_RS14310	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WPG_RS14325	COG1454	alcohol dehydrogenase
WPG_RS14365	COG1115	amino acid carrier protein
WPG_RS14375	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WPG_RS14390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WPG_RS14395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WPG_RS14420	COG1393	Belongs to the ArsC family
WPG_RS14430	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WPG_RS14445	COG1216	Glycosyl transferase, family 2
WPG_RS14460	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WPG_RS14475	COG0156	8-amino-7-oxononanoate synthase activity
WPG_RS14535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WPG_RS14550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WPG_RS14555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WPG_RS14585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WPG_RS14595	COG1215	transferase activity, transferring glycosyl groups
WPG_RS14625	COG0251	oxidation-reduction process
WPG_RS14635	COG0860	N-Acetylmuramoyl-L-alanine amidase
WPG_RS14645	COG2181	nitrate reductase activity
WPG_RS14645	COG0247	lactate metabolic process
WPG_RS14655	COG2181	nitrate reductase activity
WPG_RS14655	COG0247	lactate metabolic process
WPG_RS14665	COG0560	Phosphoserine phosphatase
WPG_RS14665	COG3830	Belongs to the UPF0237 family
WPG_RS14670	COG1472	Belongs to the glycosyl hydrolase 3 family
WPG_RS14675	COG0438	transferase activity, transferring glycosyl groups
WPG_RS14690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WPG_RS14700	COG0346	lactoylglutathione lyase activity
WPG_RS14730	COG1595	DNA-templated transcription, initiation
WPG_RS14760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WPG_RS14785	COG4974	Belongs to the 'phage' integrase family
WPG_RS14790	COG0217	transcriptional regulatory protein
WPG_RS14795	COG2154	pterin-4-alpha-carbinolamine dehydratase
WPG_RS14805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WPG_RS14815	COG0277	FAD linked oxidase domain protein
WPG_RS14815	COG0247	lactate metabolic process
WPG_RS14825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WPG_RS14835	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
WPG_RS14840	COG1301	dicarboxylic acid transport
WPG_RS14845	COG0189	ligase activity
WPG_RS14870	COG3011	Protein conserved in bacteria
WPG_RS14875	COG1193	negative regulation of DNA recombination
WPG_RS14880	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WPG_RS14910	COG0022	dehydrogenase e1 component
WPG_RS14945	COG1187	pseudouridine synthase activity
WPG_RS15085	COG4181	ATPase activity
WPG_RS15095	COG2169	Transcriptional regulator
WPG_RS15095	COG1917	Cupin 2, conserved barrel domain protein
WPG_RS15125	COG0604	alcohol dehydrogenase
WPG_RS15175	COG0405	Gamma-glutamyltransferase
WPG_RS15195	COG2197	response regulator
WPG_RS15200	COG4585	Histidine kinase
WPG_RS15220	COG1231	oxidoreductase activity
WPG_RS15270	COG3279	Response regulator of the LytR AlgR family
WPG_RS15325	COG4942	peptidase
WPG_RS15350	COG1278	Cold shock
WPG_RS15385	COG2814	Major facilitator Superfamily
WPG_RS15390	COG0668	transmembrane transport
WPG_RS15410	COG1309	transcriptional regulator
WPG_RS15440	COG0101	tRNA pseudouridine synthase activity
WPG_RS15445	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WPG_RS15445	COG0140	phosphoribosyl-ATP diphosphatase activity
WPG_RS15450	COG0107	imidazoleglycerol-phosphate synthase activity
WPG_RS15455	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WPG_RS15460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WPG_RS15465	COG0131	Imidazoleglycerol-phosphate dehydratase
WPG_RS15465	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WPG_RS15470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WPG_RS15475	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WPG_RS15480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WPG_RS15495	COG1028	Short-chain dehydrogenase reductase Sdr
WPG_RS15500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WPG_RS15510	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WPG_RS15515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WPG_RS15520	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WPG_RS15525	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WPG_RS15525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WPG_RS15530	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WPG_RS15535	COG1078	dGTPase activity
WPG_RS15540	COG2204	response regulator
WPG_RS15570	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
WPG_RS15610	COG1045	serine acetyltransferase
WPG_RS15615	COG0438	transferase activity, transferring glycosyl groups
WPG_RS15625	COG0367	asparagine synthase
WPG_RS15635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WPG_RS15650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WPG_RS15675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WPG_RS15685	COG1522	sequence-specific DNA binding
WPG_RS15705	COG0861	Integral membrane protein TerC family
WPG_RS15750	COG0012	GTP binding
WPG_RS15775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WPG_RS15785	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WPG_RS15790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WPG_RS15855	COG1228	amidohydrolase
WPG_RS15895	COG0494	nUDIX hydrolase
WPG_RS15935	COG0488	(ABC) transporter
WPG_RS15955	COG1741	Belongs to the pirin family
WPG_RS15975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WPG_RS15980	COG2223	nitrite transmembrane transporter activity
WPG_RS16005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WPG_RS16010	COG0205	6-phosphofructokinase activity
WPG_RS16020	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WPG_RS16055	COG0628	permease
WPG_RS16085	COG1480	7TM receptor with intracellular HD hydrolase
WPG_RS16090	COG0183	Belongs to the thiolase family
WPG_RS16095	COG0791	NLP P60 protein
WPG_RS16110	COG0542	response to heat
WPG_RS16120	COG2986	histidine ammonia-lyase
WPG_RS16125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WPG_RS16130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WPG_RS16135	COG0527	aspartate kinase activity
WPG_RS16135	COG0460	homoserine dehydrogenase
WPG_RS16140	COG0083	homoserine kinase activity
WPG_RS16145	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WPG_RS16185	COG2304	oxidoreductase activity
WPG_RS16190	COG0318	PFAM AMP-dependent synthetase and ligase
WPG_RS16280	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
WPG_RS16285	COG0402	S-adenosylhomocysteine deaminase activity
WPG_RS16335	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
WPG_RS16340	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WPG_RS16345	COG1575	Belongs to the MenA family. Type 1 subfamily
WPG_RS16360	COG2996	Protein conserved in bacteria
WPG_RS16370	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WPG_RS16415	COG0659	secondary active sulfate transmembrane transporter activity
WPG_RS16425	COG2070	2-Nitropropane dioxygenase
WPG_RS16430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WPG_RS16470	COG3246	L-lysine catabolic process to acetate
WPG_RS16495	COG0443	Heat shock 70 kDa protein
WPG_RS16505	COG1760	l-serine dehydratase
WPG_RS16515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WPG_RS16520	COG0564	pseudouridine synthase activity
WPG_RS16525	COG4585	Histidine kinase
WPG_RS16545	COG1984	allophanate hydrolase subunit 2
WPG_RS16550	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
WPG_RS16555	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
WPG_RS16560	COG1914	H( )-stimulated, divalent metal cation uptake system
WPG_RS16575	COG0606	chelatase, subunit chli
WPG_RS16590	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
WPG_RS16595	COG0037	tRNA processing
WPG_RS16615	COG0513	Belongs to the DEAD box helicase family
WPG_RS16620	COG0668	transmembrane transport
WPG_RS16630	COG1595	DNA-templated transcription, initiation
WPG_RS16665	COG3279	Response regulator of the LytR AlgR family
WPG_RS16680	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WPG_RS16685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WPG_RS16705	COG1522	sequence-specific DNA binding
WPG_RS16720	COG1757	Na H antiporter
WPG_RS16730	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WPG_RS16740	COG0488	(ABC) transporter
WPG_RS16750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WPG_RS16760	COG0300	oxidoreductase activity
WPG_RS16770	COG1629	transport
WPG_RS16800	COG3275	phosphorelay sensor kinase activity
WPG_RS16805	COG3279	Response regulator of the LytR AlgR family
WPG_RS16810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WPG_RS16820	COG0564	pseudouridine synthase activity
WPG_RS16865	COG0542	response to heat
WPG_RS16885	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WPG_RS16900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WPG_RS16915	COG2936	dipeptidyl-peptidase activity
WPG_RS16920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WPG_RS16925	COG0673	inositol 2-dehydrogenase activity
WPG_RS16930	COG1250	3-hydroxyacyl-CoA dehydrogenase
WPG_RS16960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WPG_RS16965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WPG_RS16980	COG0237	dephospho-CoA kinase activity
WPG_RS16990	COG1216	Glycosyl transferase, family 2
WPG_RS16990	COG0463	Glycosyl transferase, family 2
WPG_RS17005	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WPG_RS17010	COG0497	DNA recombination
WPG_RS17040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WPG_RS17055	COG0737	Belongs to the 5'-nucleotidase family
WPG_RS17070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WPG_RS17080	COG2890	protein-(glutamine-N5) methyltransferase activity
WPG_RS17085	COG0456	acetyltransferase
WPG_RS17095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WPG_RS17095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WPG_RS17100	COG1011	Hydrolase
WPG_RS17115	COG1739	Uncharacterized protein family UPF0029
WPG_RS17120	COG0824	Thioesterase
WPG_RS17155	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WPG_RS17170	COG0745	RESPONSE REGULATOR receiver
WPG_RS17170	COG2205	protein histidine kinase activity
WPG_RS17170	COG3292	Two component regulator propeller
WPG_RS17180	COG1629	transport
WPG_RS17205	COG2197	response regulator
WPG_RS17300	COG0674	pyruvate-flavodoxin oxidoreductase activity
WPG_RS17300	COG1013	pyruvate-flavodoxin oxidoreductase activity
WPG_RS17300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WPG_RS17300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WPG_RS17305	COG0674	pyruvate-flavodoxin oxidoreductase activity
WPG_RS17305	COG1013	pyruvate-flavodoxin oxidoreductase activity
WPG_RS17305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WPG_RS17305	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WPG_RS17310	COG1013	pyruvate-flavodoxin oxidoreductase activity
WPG_RS17310	COG0674	pyruvate-flavodoxin oxidoreductase activity
WPG_RS17310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WPG_RS17310	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WPG_RS17340	COG0556	nucleotide-excision repair
WPG_RS17355	COG3541	Predicted nucleotidyltransferase
WPG_RS17370	COG3275	phosphorelay sensor kinase activity
WPG_RS17395	COG5002	protein histidine kinase activity
WPG_RS17430	COG1132	(ABC) transporter
WPG_RS17440	COG1216	Glycosyl transferase, family 2
WPG_RS17445	COG0110	maltose O-acetyltransferase activity
WPG_RS17545	COG1215	transferase activity, transferring glycosyl groups
WPG_RS17590	COG2356	endonuclease I
WPG_RS17605	COG1216	Glycosyl transferase, family 2
WPG_RS17620	COG1595	DNA-templated transcription, initiation
WPG_RS17635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins