locus-tag	class	description
HM990_RS00015	ENOG4105KAC	Antibiotic biosynthesis monooxygenase
HM990_RS00070	ENOG4105C26	Dehydrogenase
HM990_RS00095	ENOG4107QM2	Aldo Keto reductase
HM990_RS00105	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HM990_RS00170	ENOG4105CHH	sulfate transporter
HM990_RS00175	ENOG41077A9	carbonic anhydrase
HM990_RS00190	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HM990_RS00205	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HM990_RS00215	ENOG4109066	lysm domain bon superfamily protein
HM990_RS00230	ENOG4108JA2	transcriptioN-repair coupling factor
HM990_RS00240	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HM990_RS00250	ENOG4105CFH	Aspartokinase
HM990_RS00280	ENOG4105WH1	Two component transcriptional regulator luxr family
HM990_RS00285	ENOG4105EWK	phytoene
HM990_RS00290	ENOG4108JQ1	Dehydrogenase
HM990_RS00300	ENOG4105CJW	magnesium transporter
HM990_RS00305	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HM990_RS00320	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HM990_RS00330	ENOG4105DTN	riboflavin biosynthesis protein ribF
HM990_RS00340	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HM990_RS00345	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HM990_RS00350	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HM990_RS00360	ENOG4105FA0	parb-like partition protein
HM990_RS00485	ENOG4108D32	Methyltransferase
HM990_RS00545	ENOG4108UUM	single-stranded DNA-binding protein
HM990_RS00630	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HM990_RS00635	ENOG4105C3J	Cysteine desulfurase
HM990_RS00675	ENOG4105JD4	ATPase yjob
HM990_RS00715	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HM990_RS00725	ENOG4105CY0	Metallo-Beta-Lactamase
HM990_RS00750	ENOG4105C5I	Dehydrogenase
HM990_RS00755	ENOG4107PU6	Membrane
HM990_RS00760	ENOG4105CTQ	phosphohexokinase
HM990_RS00775	ENOG4105EIE	fructose-bisphosphate aldolase
HM990_RS00860	ENOG4108IJF	Heavy metal efflux pump, CzcA
HM990_RS00870	ENOG4105E3B	Multicopper oxidase
HM990_RS00905	ENOG4108M4U	conserved membrane protein
HM990_RS00920	ENOG410624X	efflux transporter, rnd family, mfp subunit
HM990_RS00930	ENOG41075H3	AraC family transcriptional regulator
HM990_RS00955	ENOG4107QN2	dihydrolipoyl dehydrogenase
HM990_RS00975	ENOG4105C59	p-type ATPase
HM990_RS01010	ENOG4105D2H	Uronic isomerase
HM990_RS01015	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HM990_RS01025	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HM990_RS01030	ENOG4107QZW	Altronate oxidoreductase
HM990_RS01035	ENOG4105CTX	dehydratase
HM990_RS01040	ENOG4105ETE	Transcriptional regulator (LacI family
HM990_RS01100	ENOG4107XII	Glycosyl Hydrolase Family 88
HM990_RS01105	ENOG4105D9R	oxidoreductase
HM990_RS01110	ENOG4105E4I	Glycoside hydrolase family 28
HM990_RS01125	ENOG4107TDE	lipolytic protein G-D-S-L family
HM990_RS01140	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HM990_RS01145	ENOG4105F4R	Transcriptional regulator mode
HM990_RS01155	ENOG41080H2	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HM990_RS01160	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HM990_RS01185	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HM990_RS01190	ENOG4105E6M	Sulphatase-modifying factor protein
HM990_RS01195	ENOG4105SYT	Methylenetetrahydrofolate reductase
HM990_RS01200	ENOG4105C3R	Methionine synthase
HM990_RS01205	ENOG4105C3R	Methionine synthase
HM990_RS01210	ENOG4105C28	cystathionine
HM990_RS01225	ENOG4105CN1	protease
HM990_RS01230	ENOG4105H3G	oxidoreductase
HM990_RS01275	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HM990_RS01290	ENOG4108HRK	Histidine kinase
HM990_RS01295	ENOG4105DY9	regulatoR
HM990_RS01300	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HM990_RS01305	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HM990_RS01355	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HM990_RS01365	ENOG4108Z6B	deaminase
HM990_RS01380	ENOG4105C0B	DNA polymerase III (alpha subunit)
HM990_RS01400	ENOG4108T1X	regulatory protein FlaEY
HM990_RS01415	ENOG4105BZU	Histidine kinase
HM990_RS01450	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HM990_RS01455	ENOG4105CSA	Coproporphyrinogen iii oxidase
HM990_RS01475	ENOG4105MSB	protein, conserved in bacteria
HM990_RS01490	ENOG4105BZU	Histidine kinase
HM990_RS01500	ENOG4105BZU	Histidine kinase
HM990_RS01510	ENOG4105DY9	regulatoR
HM990_RS01570	ENOG4105DG6	mannose-6-phosphate isomerase
HM990_RS01575	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HM990_RS01605	ENOG4105VEQ	Cold shock protein
HM990_RS01620	ENOG4105C9M	aspartyl-trna synthetase
HM990_RS01625	ENOG4105BZS	acriflavin resistance protein
HM990_RS01660	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
HM990_RS01745	ENOG4105C7S	Dehydrogenase
HM990_RS01750	ENOG4107ZHV	Transcriptional regulator
HM990_RS01760	ENOG4105F8V	Hydrolase, tatD family
HM990_RS01765	ENOG4105HDK	L-asparaginase
HM990_RS01810	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HM990_RS01815	ENOG4105C5S	asparaginyl-tRNA synthetase
HM990_RS01830	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HM990_RS01835	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HM990_RS01840	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HM990_RS01845	ENOG4105CE9	30S ribosomal protein S2
HM990_RS01850	ENOG4108UJD	30S ribosomal protein S9
HM990_RS01855	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HM990_RS01865	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HM990_RS01880	ENOG4105C5H	ABC transporter
HM990_RS01885	ENOG4105CCT	upf0313 protein
HM990_RS01895	ENOG4105WDY	DNA (cytosine-5-)-methyltransferase
HM990_RS01905	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
HM990_RS01910	ENOG4105C2M	dna polymerase I
HM990_RS01950	ENOG4105DY9	regulatoR
HM990_RS01965	ENOG4105K63	Thioredoxin
HM990_RS01990	ENOG41090IP	Required for maturation of 30S ribosomal subunits (By similarity)
HM990_RS01995	ENOG4105CHV	Transcription elongation factor NusA
HM990_RS02000	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HM990_RS02020	ENOG4107SFQ	iron-sulfur binding
HM990_RS02025	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HM990_RS02045	ENOG4105E2S	oxidase) subunit II
HM990_RS02050	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HM990_RS02055	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HM990_RS02060	ENOG4105JZI	cytochrome P450
HM990_RS02065	ENOG4105CA0	peroxidase
HM990_RS02085	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HM990_RS02090	ENOG4105ETE	Transcriptional regulator (LacI family
HM990_RS02100	ENOG4107RBJ	symporter
HM990_RS02105	ENOG4107Y7Q	pfkb domain protein
HM990_RS02110	ENOG4107RK0	Sucrose phosphorylase
HM990_RS02125	ENOG4105C6K	Malic enzyme
HM990_RS02130	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HM990_RS02140	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HM990_RS02200	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HM990_RS02205	ENOG4105CCU	oxidase (Subunit III)
HM990_RS02225	ENOG4108KF3	Electron transport protein SCO1 SenC
HM990_RS02230	ENOG4108SJC	Membrane
HM990_RS02240	ENOG4105C19	ABC transporter
HM990_RS02245	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HM990_RS02250	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HM990_RS02255	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HM990_RS02270	ENOG41072GX	Peptidase M22 Glycoprotease
HM990_RS02275	ENOG4105D64	Mechanosensitive ion channel
HM990_RS02290	ENOG41083MR	nifu domain-containing protein
HM990_RS02320	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HM990_RS02345	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HM990_RS02350	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HM990_RS02355	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HM990_RS02370	ENOG4105EV9	Alpha Beta Hydrolase
HM990_RS02375	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HM990_RS02385	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HM990_RS02395	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HM990_RS02415	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HM990_RS02425	ENOG4108Z0R	Transferase
HM990_RS02430	ENOG41083X6	30S ribosomal protein S21
HM990_RS02460	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HM990_RS02465	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HM990_RS02495	ENOG4105CHR	reductase
HM990_RS02500	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HM990_RS02505	ENOG410854A	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HM990_RS02520	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HM990_RS02530	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HM990_RS02545	ENOG4105CJ1	ABC, transporter
HM990_RS02575	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HM990_RS02580	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HM990_RS02610	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HM990_RS02620	ENOG41088M2	Glycosyl transferase family 2
HM990_RS02645	ENOG4105E2Q	3-(3-hydroxy-phenyl)propionate hydroxylase
HM990_RS02755	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HM990_RS02760	ENOG4105CMR	udp-glucose 4-epimerase
HM990_RS02765	ENOG4105CPN	adenine deaminase
HM990_RS02775	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HM990_RS02780	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HM990_RS02785	ENOG4108UW5	maltose o-acetyltransferase
HM990_RS02790	ENOG4105DZ0	fad dependent oxidoreductase
HM990_RS02795	ENOG4107PU6	Membrane
HM990_RS02805	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HM990_RS02810	ENOG4105ZMH	deoxynucleoside kinase
HM990_RS02850	ENOG4107ZT5	Thiol disulfide interchange protein
HM990_RS02865	ENOG4105C26	Dehydrogenase
HM990_RS02875	ENOG4105NWN	ApaG protein
HM990_RS02895	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HM990_RS02900	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HM990_RS02905	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
HM990_RS02935	ENOG4107QHQ	amino acid
HM990_RS02940	ENOG4105DHF	Membrane
HM990_RS02950	ENOG4107T66	Releases the N-terminal proline from various substrates (By similarity)
HM990_RS02955	ENOG4105KME	endoribonuclease L-psp
HM990_RS02975	ENOG4105DY9	regulatoR
HM990_RS02995	ENOG4105CJ2	(LipO)protein
HM990_RS03015	ENOG4105CYC	Transferase
HM990_RS03025	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HM990_RS03040	ENOG4105EQ6	Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity)
HM990_RS03065	ENOG4108CSZ	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HM990_RS03085	ENOG4105C3W	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity)
HM990_RS03090	ENOG4105CHR	reductase
HM990_RS03105	ENOG4107RQD	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity)
HM990_RS03110	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
HM990_RS03115	ENOG4105BZU	Histidine kinase
HM990_RS03130	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HM990_RS03140	ENOG4105EGD	dinuclear metal center protein, YbgI family
HM990_RS03145	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HM990_RS03160	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HM990_RS03180	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HM990_RS03190	ENOG4105EMN	RNA polymerase sigma factor
HM990_RS03195	ENOG4107R0I	Cell wall formation (By similarity)
HM990_RS03215	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HM990_RS03220	ENOG4105CNI	cell division protein FtsW
HM990_RS03225	ENOG4105CJN	penicillin-binding protein
HM990_RS03240	ENOG4105DFF	Rod shape-determining protein mreb
HM990_RS03245	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HM990_RS03255	ENOG4107S85	alpha-2-macroglobulin domain protein
HM990_RS03270	ENOG4108JJA	ABC, transporter
HM990_RS03285	ENOG4105DFU	Cell wall formation (By similarity)
HM990_RS03330	ENOG4105W5Q	DNA repair protein (RadC
HM990_RS03350	ENOG4105D1H	recombination factor protein RarA
HM990_RS03360	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HM990_RS03395	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HM990_RS03400	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HM990_RS03405	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HM990_RS03410	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HM990_RS03415	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HM990_RS03420	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HM990_RS03425	ENOG41082S5	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HM990_RS03430	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HM990_RS03435	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HM990_RS03440	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HM990_RS03445	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HM990_RS03450	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HM990_RS03455	ENOG4105WNB	50s ribosomal protein l29
HM990_RS03460	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HM990_RS03465	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HM990_RS03470	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HM990_RS03475	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HM990_RS03480	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HM990_RS03485	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HM990_RS03490	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HM990_RS03495	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HM990_RS03500	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HM990_RS03505	ENOG41084HK	50S ribosomal protein L30
HM990_RS03510	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HM990_RS03515	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HM990_RS03520	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HM990_RS03525	ENOG410864M	50S ribosomal protein L36
HM990_RS03530	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HM990_RS03535	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HM990_RS03540	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HM990_RS03545	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HM990_RS03550	ENOG4108ZT0	50S ribosomal protein l17
HM990_RS03555	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HM990_RS03560	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HM990_RS03600	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
HM990_RS03605	ENOG4105KNE	Phosphatidate cytidylyltransferase
HM990_RS03615	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HM990_RS03620	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HM990_RS03635	ENOG4107RIV	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HM990_RS03640	ENOG41062IR	nudix hydrolase
HM990_RS03655	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HM990_RS03670	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HM990_RS03690	ENOG4105BZU	Histidine kinase
HM990_RS03695	ENOG4105C75	arginyL-tRNA synthetase
HM990_RS03720	ENOG4108S3W	Anti-feci sigma factor, fecr
HM990_RS03745	ENOG4105D7A	ATP-binding protein
HM990_RS03755	ENOG4108Z2K	Cupin 2, conserved barrel domain protein
HM990_RS03765	ENOG4105FE9	pseudouridine synthase
HM990_RS03785	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HM990_RS03800	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
HM990_RS03810	ENOG4105CAQ	asparagine synthetase
HM990_RS03815	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HM990_RS03850	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HM990_RS03870	ENOG4107QZC	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HM990_RS03875	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HM990_RS03880	ENOG4105C8N	cysteinyl-tRNA synthetase
HM990_RS03885	ENOG4105EUJ	GTP cyclohydrolase i
HM990_RS03910	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HM990_RS03920	ENOG4105RA3	Binds directly to 16S ribosomal RNA (By similarity)
HM990_RS03950	ENOG4105BZU	Histidine kinase
HM990_RS03990	ENOG4108K8S	endonuclease I
HM990_RS04000	ENOG4107R5B	glutamine synthetase
HM990_RS04020	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HM990_RS04035	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HM990_RS04040	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
HM990_RS04045	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HM990_RS04065	ENOG4105D5P	Methylmalonyl-coA mutase
HM990_RS04085	ENOG4108YXU	transcriptional regulator AsnC family
HM990_RS04095	ENOG4105E4T	pyridine nucleotide-disulfide oxidoreductase
HM990_RS04105	ENOG4107XZQ	multidrug resistance protein
HM990_RS04120	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HM990_RS04130	ENOG4105CI3	gtp-binding protein typa
HM990_RS04150	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HM990_RS04160	ENOG4105CKK	Glycosyl transferase, family 2
HM990_RS04175	ENOG4105EGZ	biosynthesis protein
HM990_RS04205	ENOG4105K64	Glycosyl transferase, family 2
HM990_RS04210	ENOG4105K64	Glycosyl transferase, family 2
HM990_RS04220	ENOG4105CAK	Cell division ATP-binding protein ftsE
HM990_RS04230	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HM990_RS04235	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HM990_RS04240	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HM990_RS04245	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HM990_RS04250	ENOG4105DDQ	anthranilate synthase
HM990_RS04255	ENOG4105CRQ	synthase (Component I)
HM990_RS04265	ENOG410834F	Transcriptional regulator
HM990_RS04280	ENOG41085GJ	domain protein
HM990_RS04320	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HM990_RS04325	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HM990_RS04330	ENOG4105E0X	reductase
HM990_RS04360	ENOG4105WH1	Two component transcriptional regulator luxr family
HM990_RS04370	ENOG4105BZU	Histidine kinase
HM990_RS04375	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HM990_RS04380	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
HM990_RS04385	ENOG4105E98	transcriptional regulator DeoR family
HM990_RS04390	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HM990_RS04400	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HM990_RS04440	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HM990_RS04455	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
HM990_RS04500	ENOG4105F6J	Alpha beta hydrolase fold
HM990_RS04525	ENOG4105EMN	RNA polymerase sigma factor
HM990_RS04535	ENOG4105C1J	atp-dependent rna helicase
HM990_RS04540	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
HM990_RS04560	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
HM990_RS04565	ENOG4108RPX	mosc domain containing protein
HM990_RS04590	ENOG4105FQP	Beta-lactamase
HM990_RS04600	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HM990_RS04605	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HM990_RS04615	ENOG4105X54	addiction module antidote protein
HM990_RS04640	ENOG4107RJ1	sodium solute
HM990_RS04655	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HM990_RS04670	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HM990_RS04675	ENOG4105D3R	alkyl hydroperoxide reductase
HM990_RS04695	ENOG4107RZZ	dna polymerase iii epsilon subunit
HM990_RS04700	ENOG4105FBJ	fumarylacetoacetate (faa) hydrolase
HM990_RS04710	ENOG4105CEV	competence damage-inducible protein
HM990_RS04715	ENOG4105KDC	50s ribosomal protein l28
HM990_RS04720	ENOG41083ND	50S ribosomal protein L33
HM990_RS04730	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HM990_RS04740	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HM990_RS04750	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HM990_RS04760	ENOG4107ENK	receptor
HM990_RS04810	ENOG41074B2	UPF0747 protein
HM990_RS04815	ENOG4105DY8	decarboxylase
HM990_RS04855	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HM990_RS04900	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HM990_RS04905	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HM990_RS04920	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HM990_RS04930	ENOG4105EA8	2-Nitropropane dioxygenase
HM990_RS04965	ENOG4107QI1	Mate efflux family protein
HM990_RS04990	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HM990_RS05005	ENOG4105EMN	RNA polymerase sigma factor
HM990_RS05050	ENOG4108HRK	Histidine kinase
HM990_RS05070	ENOG4105DY9	regulatoR
HM990_RS05125	ENOG4105D4P	Coproporphyrinogen iii oxidase
HM990_RS05130	ENOG4108U51	Universal stress protein
HM990_RS05155	ENOG4105C58	cytochrome c oxidase accessory protein ccog
HM990_RS05170	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HM990_RS05185	ENOG4107V6Q	Cyclic nucleotide-binding domain
HM990_RS05305	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HM990_RS05315	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HM990_RS05325	ENOG4105C8Y	Acetylornithine aminotransferase
HM990_RS05355	ENOG4105C3J	Cysteine desulfurase
HM990_RS05390	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HM990_RS05405	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HM990_RS05415	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HM990_RS05425	ENOG4107QN2	dihydrolipoyl dehydrogenase
HM990_RS05440	ENOG4105E0X	reductase
HM990_RS05445	ENOG4107QPH	glycogen) synthase
HM990_RS05455	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
HM990_RS05460	ENOG4105BZP	glycoside hydrolase 15-related
HM990_RS05465	ENOG4107S9Q	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
HM990_RS05470	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
HM990_RS05475	ENOG4107R91	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HM990_RS05500	ENOG4107SN7	NLP P60 protein
HM990_RS05505	ENOG4105CHU	acetyl-coa acetyltransferase
HM990_RS05510	ENOG4105CTJ	Metal Dependent Phosphohydrolase
HM990_RS05535	ENOG4107T0X	DNA ligase
HM990_RS05585	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HM990_RS05595	ENOG4105CTQ	phosphohexokinase
HM990_RS05610	ENOG4108Z5K	methylglyoxal synthase
HM990_RS05625	ENOG4107QX3	carboxylase
HM990_RS05655	ENOG4105C5H	ABC transporter
HM990_RS05680	ENOG4107VIJ	nudix hydrolase
HM990_RS05715	ENOG4105CYW	agmatinase
HM990_RS05725	ENOG4105CI2	imidazolone-5-propionate hydrolase
HM990_RS05735	ENOG4105C9Q	fumarate hydratase class II
HM990_RS05755	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
HM990_RS05770	ENOG4107UI5	Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity)
HM990_RS05775	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HM990_RS05785	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HM990_RS05810	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HM990_RS05820	ENOG4105D05	Receptor
HM990_RS05850	ENOG4108JQ1	Dehydrogenase
HM990_RS05855	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HM990_RS05865	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HM990_RS05905	ENOG410836F	Transposase
HM990_RS05930	ENOG4108IUK	alpha amylase, catalytic
HM990_RS05935	ENOG4105CBG	Sulfatase
HM990_RS05940	ENOG410836F	Transposase
HM990_RS05955	ENOG4107UQD	Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity)
HM990_RS06025	ENOG4105C0H	protease
HM990_RS06030	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HM990_RS06040	ENOG4105HHA	aminodeoxychorismate lyase
HM990_RS06055	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HM990_RS06065	ENOG4105KJF	protein tyrosine phosphatase
HM990_RS06070	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HM990_RS06080	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HM990_RS06085	ENOG4108TZV	Membrane
HM990_RS06095	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HM990_RS06105	ENOG4108MJ3	acetyltransferase
HM990_RS06110	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HM990_RS06115	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HM990_RS06125	ENOG4105CGH	5'-nucleotidase
HM990_RS06140	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HM990_RS06165	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HM990_RS06190	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HM990_RS06210	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HM990_RS06215	ENOG4105EYW	Ion transport protein
HM990_RS06225	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HM990_RS06230	ENOG4105DFA	alanine racemase domain protein
HM990_RS06245	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HM990_RS06250	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HM990_RS06255	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HM990_RS06260	ENOG4105GYP	Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity)
HM990_RS06280	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HM990_RS06300	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HM990_RS06305	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HM990_RS06315	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HM990_RS06340	ENOG4105D3G	Pseudouridine synthase
HM990_RS06350	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HM990_RS06390	ENOG4105E1F	short-chain dehydrogenase reductase
HM990_RS06400	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HM990_RS06410	ENOG4105C5H	ABC transporter
HM990_RS06425	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
HM990_RS06430	ENOG4108MCI	Transcriptional regulator, ARAC family
HM990_RS06445	ENOG41080RH	Thioredoxin
HM990_RS06450	ENOG4105D3R	alkyl hydroperoxide reductase
HM990_RS06455	ENOG4105DFD	Na H antiporter
HM990_RS06465	ENOG4105C28	cystathionine
HM990_RS06470	ENOG4105J0Q	Transcriptional regulator
HM990_RS06480	ENOG4107QN2	dihydrolipoyl dehydrogenase
HM990_RS06485	ENOG4105RKW	reductase (By
HM990_RS06495	ENOG4105DY9	regulatoR
HM990_RS06500	ENOG4108HRK	Histidine kinase
HM990_RS06530	ENOG4105C1J	atp-dependent rna helicase
HM990_RS06540	ENOG4105CRQ	synthase (Component I)
HM990_RS06555	ENOG4105CPN	adenine deaminase
HM990_RS06560	ENOG4105C26	Dehydrogenase
HM990_RS06565	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HM990_RS06570	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HM990_RS06585	ENOG4105BZ8	glutamate synthase
HM990_RS06590	ENOG4107SJI	Dehydrogenase
HM990_RS06600	ENOG4105DNZ	Alpha Beta Hydrolase
HM990_RS06625	ENOG4105C0P	Mg chelatase subunit ChlI
HM990_RS06655	ENOG4105E7W	lamb ycsf family protein
HM990_RS06660	ENOG4105P4J	Allophanate hydrolase, subunit 1
HM990_RS06680	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HM990_RS06690	ENOG4108RCM	Nitroreductase
HM990_RS06695	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HM990_RS06755	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HM990_RS06770	ENOG4105CNU	cell division protein FtsK
HM990_RS06785	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
HM990_RS06815	ENOG4105D7N	magnesium and cobalt transport protein CorA
HM990_RS06830	ENOG4108Z03	MAF-like protein
HM990_RS06865	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HM990_RS06870	ENOG4105CRE	cytochrome C
HM990_RS06875	ENOG4105C28	cystathionine
HM990_RS06885	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HM990_RS06890	ENOG4107QWE	)-transporter
HM990_RS06895	ENOG4107W19	lmbE family
HM990_RS06915	ENOG4108I0Z	Aconitate hydratase
HM990_RS06930	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HM990_RS06965	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HM990_RS06970	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HM990_RS06980	ENOG4105VEJ	Heat shock protein
HM990_RS06995	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HM990_RS07000	ENOG4108HHA	Transketolase
HM990_RS07005	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HM990_RS07020	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HM990_RS07025	ENOG4105CDU	Replicative dna helicase
HM990_RS07030	ENOG4105DSF	transport protein
HM990_RS07035	ENOG4105F0I	Aminotransferase
HM990_RS07060	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
HM990_RS07065	ENOG4108HCJ	Hydrolase
HM990_RS07070	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HM990_RS07075	ENOG4105VJV	50s ribosomal protein L35
HM990_RS07080	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HM990_RS07085	ENOG4105C22	threonyL-tRNA synthetase
HM990_RS07120	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HM990_RS07125	ENOG4105EJQ	L-serine dehydratase
HM990_RS07135	ENOG4105CFG	Acts as a chaperone (By similarity)
HM990_RS07150	ENOG4105C84	Histidine ammonia-lyase
HM990_RS07210	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HM990_RS07225	ENOG4105CAT	Cytidine monophosphate kinase
HM990_RS07235	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HM990_RS07240	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HM990_RS07245	ENOG4105CXT	aspartate transcarbamylase
HM990_RS07255	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HM990_RS07265	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HM990_RS07280	ENOG4105UYK	outer membrane protein a
HM990_RS07300	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HM990_RS07315	ENOG4105IIU	Aminopeptidase
HM990_RS07320	ENOG4105IIU	Aminopeptidase
HM990_RS07335	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HM990_RS07360	ENOG41061MV	Arylsulfatase
HM990_RS07370	ENOG41061MV	Arylsulfatase
HM990_RS07380	ENOG4105EF1	ribulokinase
HM990_RS07385	ENOG4105EDR	glucose galactose transporter
HM990_RS07405	ENOG4105ETE	Transcriptional regulator (LacI family
HM990_RS07445	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HM990_RS07450	ENOG4105D60	lipoprotein releasing system transmembrane protein
HM990_RS07470	ENOG4105BZU	Histidine kinase
HM990_RS07475	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HM990_RS07495	ENOG4107YZX	Universal stress protein
HM990_RS07515	ENOG4105CY0	Metallo-Beta-Lactamase
HM990_RS07535	ENOG4107YZX	Universal stress protein
HM990_RS07550	ENOG4105E9K	Isocitrate dehydrogenase
HM990_RS07560	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HM990_RS07565	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HM990_RS07570	ENOG4105DF9	Lipoate-protein, ligase
HM990_RS07575	ENOG4108WC5	Alpha Beta Hydrolase Fold protein
HM990_RS07580	ENOG4105DGW	oligopeptidase A
HM990_RS07585	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HM990_RS07610	ENOG4105CEP	NADH dehydrogenase
HM990_RS07630	ENOG41068WN	
HM990_RS07640	ENOG4105D6J	arsenicaL-resistance protein
HM990_RS07675	ENOG4105D98	threonine synthase
HM990_RS07685	ENOG4107RDY	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
HM990_RS07690	ENOG4105CFH	Aspartokinase
HM990_RS07695	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HM990_RS07700	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HM990_RS07705	ENOG4105DR4	Methyltransferase
HM990_RS07755	ENOG4105KA0	thioesterase Superfamily protein
HM990_RS07760	ENOG4105E4F	Isochorismate synthase
HM990_RS07765	ENOG4107RE3	peptidase, S41
HM990_RS07770	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
HM990_RS07780	ENOG4105QNR	S1 RNA binding domain protein
HM990_RS07795	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
HM990_RS07800	ENOG4107W2A	UPF0173 metal-dependent hydrolase
HM990_RS07820	ENOG4105DTQ	mandelate racemase muconate lactonizing
HM990_RS07835	ENOG4105CP2	von willebrand factor, type a
HM990_RS07845	ENOG4108HRK	Histidine kinase
HM990_RS07850	ENOG4108NEV	two component transcriptional regulator, LytTR family
HM990_RS07855	ENOG410836F	Transposase
HM990_RS07865	ENOG4105C3G	gtp-binding protein
HM990_RS07875	ENOG4108UZ3	Transporter
HM990_RS07885	ENOG4105DNX	Dna topoisomerase iv (Subunit b)
HM990_RS07895	ENOG4105DF5	DNA topoisomerase IV, subunit A
HM990_RS07905	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HM990_RS07910	ENOG4105EE5	Membrane protein terC
HM990_RS07930	ENOG4108VVK	transcriptional Regulator, AsnC
HM990_RS07940	ENOG4105D49	3-dehydroquinate synthase
HM990_RS07945	ENOG41062BK	proline dehydrogenase
HM990_RS07965	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HM990_RS07980	ENOG4105D3Q	Sugar transferase
HM990_RS07990	ENOG4105CAQ	asparagine synthetase
HM990_RS07995	ENOG4105CG5	Glycosyl transferase (Group 1
HM990_RS08010	ENOG4105K64	Glycosyl transferase, family 2
HM990_RS08020	ENOG4105CG5	Glycosyl transferase (Group 1
HM990_RS08030	ENOG4105K64	Glycosyl transferase, family 2
HM990_RS08040	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HM990_RS08070	ENOG4105K8N	protein family UPF0079, ATPase
HM990_RS08075	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HM990_RS08080	ENOG4105DCI	Phosphohydrolase
HM990_RS08085	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HM990_RS08090	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HM990_RS08095	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HM990_RS08100	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HM990_RS08105	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HM990_RS08115	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HM990_RS08120	ENOG4105CHR	reductase
HM990_RS08145	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HM990_RS08165	ENOG4108RMU	ferritin dps family protein
HM990_RS08195	ENOG4108RAV	Conserved protein
HM990_RS08205	ENOG4105CUY	Mechanosensitive ion channel
HM990_RS08210	ENOG4105VCH	membrane
HM990_RS08220	ENOG4105VEQ	Cold shock protein
HM990_RS08245	ENOG4108K5P	(LipO)protein
HM990_RS08255	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HM990_RS08275	ENOG4105C1J	atp-dependent rna helicase
HM990_RS08290	ENOG4105VEQ	Cold shock protein
HM990_RS08310	ENOG4105C26	Dehydrogenase
HM990_RS08315	ENOG4107GJV	short-chain dehydrogenase reductase
HM990_RS08325	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HM990_RS08455	ENOG4105Y7M	Transcriptional regulator, TetR family
HM990_RS08460	ENOG4105K4T	epimerase
HM990_RS08470	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
HM990_RS08475	ENOG4108I6A	alcohol dehydrogenase
HM990_RS08500	ENOG4105F57	Anthranilate dioxygenase reductase
HM990_RS08510	ENOG4107S1E	Beta-lactamase
HM990_RS08520	ENOG4105DEN	Luciferase family
HM990_RS08525	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HM990_RS08540	ENOG4105DJT	lAO AO transport system ATPase
HM990_RS08550	ENOG4105D5P	Methylmalonyl-coA mutase
HM990_RS08555	ENOG4105CMN	Methylmalonyl-coA mutase
HM990_RS08560	ENOG4105CYC	Transferase
HM990_RS08565	ENOG4105D9Q	decarboxylase (Beta subunit)
HM990_RS08570	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
HM990_RS08580	ENOG4107QX3	carboxylase
HM990_RS08590	ENOG4105C1G	acyl-Coa dehydrogenase
HM990_RS08615	ENOG4105WH1	Two component transcriptional regulator luxr family
HM990_RS08635	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
HM990_RS08665	ENOG4105CSV	Glutaminase
HM990_RS08675	ENOG4105NPQ	Pfam:DUF403
HM990_RS08710	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HM990_RS08715	ENOG4105EGS	Mechanosensitive ion channel
HM990_RS08720	ENOG4105VDW	Csbd family
HM990_RS08730	ENOG4105CV6	ABC transporter, permease
HM990_RS08735	ENOG4108I0Y	(ABC) transporter
HM990_RS08740	ENOG4108UJV	acyl-CoA thioesterase i
HM990_RS08755	ENOG4105D64	Mechanosensitive ion channel
HM990_RS08820	ENOG4105D8V	Glucose sorbosone dehydrogenase
HM990_RS08830	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HM990_RS08850	ENOG4108R99	pseudouridine synthase
HM990_RS08860	ENOG4105KHC	sulfurtransferase
HM990_RS08870	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HM990_RS08880	ENOG4105CQB	FAD linked oxidase domain protein
HM990_RS08930	ENOG4108QY0	Membrane
HM990_RS08935	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HM990_RS08945	ENOG4105KZX	Pterin carbinolamine dehydratase
HM990_RS08950	ENOG4105CDY	transcriptional regulatory protein
HM990_RS08970	ENOG4105EE0	oxidoreductase
HM990_RS08995	ENOG4105CGD	Nad-dependent epimerase dehydratase
HM990_RS09010	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
HM990_RS09015	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HM990_RS09030	ENOG4105EUJ	GTP cyclohydrolase i
HM990_RS09045	ENOG4108V06	Glutathione peroxidase
HM990_RS09065	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HM990_RS09075	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HM990_RS09095	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HM990_RS09100	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HM990_RS09105	ENOG4105K70	DNA-binding protein
HM990_RS09110	ENOG4108UJU	UPF0301 protein
HM990_RS09115	ENOG4105F0I	Aminotransferase
HM990_RS09145	ENOG4105DZR	Type I site-specific deoxyribonuclease
HM990_RS09170	ENOG4105CVR	type I restriction-modification system
HM990_RS09175	ENOG4105KWG	Pfam:DUF1696
HM990_RS09195	ENOG4105KK6	nuclease
HM990_RS09250	ENOG4107QWK	SAICAR synthetase
HM990_RS09255	ENOG4105C9A	Phoh family
HM990_RS09260	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
HM990_RS09295	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HM990_RS09310	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
HM990_RS09360	ENOG4105K63	Thioredoxin
HM990_RS09385	ENOG4105D64	Mechanosensitive ion channel
HM990_RS09425	ENOG4108M4U	conserved membrane protein
HM990_RS09440	ENOG4105DQE	DNA ligase
HM990_RS09445	ENOG4105FDF	Could be involved in DNA repair (By similarity)
HM990_RS09465	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HM990_RS09475	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HM990_RS09495	ENOG4105C5I	Dehydrogenase
HM990_RS09500	ENOG4105EZV	Transcriptional regulator
HM990_RS09555	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HM990_RS09555	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HM990_RS09565	ENOG4105D74	hydrolase
HM990_RS09590	ENOG4105C31	Tryptophanyl-tRNA synthetase
HM990_RS09605	ENOG4108HRK	Histidine kinase
HM990_RS09610	ENOG4108NEV	two component transcriptional regulator, LytTR family
HM990_RS09625	ENOG4105EMN	RNA polymerase sigma factor
HM990_RS09645	ENOG4105DY9	regulatoR
HM990_RS09655	ENOG4105CJ1	ABC, transporter
HM990_RS09670	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HM990_RS09675	ENOG4107ZT5	Thiol disulfide interchange protein
HM990_RS09685	ENOG4105D1S	lipid A biosynthesis
HM990_RS09695	ENOG4107QKV	phosphomannomutase
HM990_RS09735	ENOG4108ETH	Formylglycinamide ribotide synthetase
HM990_RS09750	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
HM990_RS09765	ENOG4105CHU	acetyl-coa acetyltransferase
HM990_RS09770	ENOG4105C1G	acyl-Coa dehydrogenase
HM990_RS09780	ENOG4105C6E	dna polymerase iii
HM990_RS09800	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HM990_RS09805	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HM990_RS09815	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HM990_RS09845	ENOG4105CD8	aminopeptidase N
HM990_RS09855	ENOG4108Z0Z	intracellular protease Pfpi family
HM990_RS09870	ENOG4105K3M	)-transporter
HM990_RS09875	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HM990_RS09910	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HM990_RS09915	ENOG4108U51	Universal stress protein
HM990_RS09920	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HM990_RS09940	ENOG4108JA2	transcriptioN-repair coupling factor
HM990_RS09955	ENOG4105VN1	Heat shock protein
HM990_RS09960	ENOG4105CPP	Dehydrogenase, E1 component
HM990_RS09980	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
HM990_RS09990	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HM990_RS09995	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
HM990_RS10000	ENOG4105C98	muts2 protein
HM990_RS10005	ENOG4105KIR	Thiol-disulfide oxidoreductase dcc
HM990_RS10010	ENOG4105VIE	preprotein translocase, subunit YajC
HM990_RS10020	ENOG4107R6T	Involved in the transcription termination process (By similarity)
HM990_RS10025	ENOG4107RDP	Dehydrogenase
HM990_RS10030	ENOG4105BZ1	(ABC) transporter
HM990_RS10040	ENOG4108Z7R	Chaperone CsaA
HM990_RS10060	ENOG4108UT2	hemolysin iii
HM990_RS10070	ENOG4105CN9	Peptidase m42 family protein
HM990_RS10075	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
HM990_RS10080	ENOG4108PNU	Involved in the degradation of specific anti-sigma factors (By similarity)
HM990_RS10090	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HM990_RS10095	ENOG4107QX3	carboxylase
HM990_RS10100	ENOG4105BZ1	(ABC) transporter
HM990_RS10110	ENOG4105C2C	drug resistance transporter, Bcr CflA
HM990_RS10115	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HM990_RS10135	ENOG4105C4R	Atp-dependent dna helicase
HM990_RS10150	ENOG4105CPK	Glycosyl transferase (Group 1
HM990_RS10155	ENOG4105D17	glycoside hydrolase, family 3 domain protein
HM990_RS10160	ENOG4105EAC	phosphoserine phosphatase
HM990_RS10180	ENOG4105DF6	Fe-S oxidoreductase
HM990_RS10185	ENOG4105DF6	Fe-S oxidoreductase
HM990_RS10190	ENOG4107KIA	Virulence factor Mce family protein
HM990_RS10195	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HM990_RS10225	ENOG4105DQ6	Transposase
HM990_RS10250	ENOG4105BZU	Histidine kinase
HM990_RS10260	ENOG4105K64	Glycosyl transferase, family 2
HM990_RS10310	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HM990_RS10315	ENOG4105CSM	endonuclease III
HM990_RS10325	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HM990_RS10380	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HM990_RS10395	ENOG41080WS	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HM990_RS10405	ENOG4105K64	Glycosyl transferase, family 2
HM990_RS10425	ENOG4105K89	arsenate reductase
HM990_RS10440	ENOG4107RET	Isocitrate lyase
HM990_RS10445	ENOG4107QP3	malate synthase g
HM990_RS10455	ENOG4105DQ4	alcohol dehydrogenase
HM990_RS10470	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HM990_RS10480	ENOG4105C26	Dehydrogenase
HM990_RS10505	ENOG4107QN1	sodium solute
HM990_RS10515	ENOG4105BZG	amino acid carrier protein
HM990_RS10520	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HM990_RS10550	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HM990_RS10570	ENOG4105C34	Pseudouridine synthase
HM990_RS10595	ENOG4105E0A	ABC, transporter
HM990_RS10600	ENOG4105EHG	Permease protein
HM990_RS10610	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HM990_RS10630	ENOG4105T65	Membrane-associated protein
HM990_RS10645	ENOG4107QTF	adenylosuccinate lyase
HM990_RS10660	ENOG4105CGY	Dna recombination protein
HM990_RS10690	ENOG4105VG0	50S ribosomal protein l34
HM990_RS10700	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HM990_RS10725	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HM990_RS10765	ENOG41081WG	50s ribosomal protein l31
HM990_RS10775	ENOG4105CKK	Glycosyl transferase, family 2
HM990_RS10785	ENOG4105BZ1	(ABC) transporter
HM990_RS10815	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HM990_RS10835	ENOG4108URH	decarboxylase
HM990_RS10850	ENOG4105CPP	Dehydrogenase, E1 component
HM990_RS10860	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HM990_RS10865	ENOG4108D32	Methyltransferase
HM990_RS10915	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
HM990_RS10925	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HM990_RS10930	ENOG4105C2X	Arabinose 5-phosphate isomerase
HM990_RS10935	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HM990_RS10940	ENOG4108X7C	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HM990_RS10945	ENOG4108IUZ	ABC transporter
HM990_RS10950	ENOG4105CKW	Inner membrane protein yedI
HM990_RS10955	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HM990_RS11010	ENOG4107XB0	Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
HM990_RS11015	ENOG4105FAT	Acyl-transferase
HM990_RS11025	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HM990_RS11035	ENOG41090RK	glycosyl transferase
HM990_RS11045	ENOG4107T8Q	Glycosyl transferase (Group 1
HM990_RS11050	ENOG4107T8Q	Glycosyl transferase (Group 1
HM990_RS11055	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HM990_RS11080	ENOG4107S6X	Glycosyl transferase, family 2
HM990_RS11085	ENOG4105K64	Glycosyl transferase, family 2
HM990_RS11115	ENOG4107QQG	Dehydrogenase
HM990_RS11120	ENOG4105D3Q	Sugar transferase
HM990_RS11125	ENOG4105D75	Capsular exopolysaccharide family
HM990_RS11135	ENOG4105C5H	ABC transporter
HM990_RS11145	ENOG4105C19	ABC transporter
HM990_RS11165	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HM990_RS11175	ENOG4105VC4	domain protein
HM990_RS11220	ENOG4105CBS	Chea signal transduction histidine kinase
HM990_RS11230	ENOG4105CVR	type I restriction-modification system
HM990_RS11285	ENOG4108HRK	Histidine kinase
HM990_RS11290	ENOG4108NEV	two component transcriptional regulator, LytTR family
HM990_RS11310	ENOG4105C8P	)-transporter
HM990_RS11345	ENOG4105CUT	histidyl-tRNA synthetase
HM990_RS11350	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HM990_RS11360	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HM990_RS11365	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HM990_RS11370	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HM990_RS11375	ENOG41080B9	Binds together with S18 to 16S ribosomal RNA (By similarity)
HM990_RS11380	ENOG4108NEV	two component transcriptional regulator, LytTR family
HM990_RS11385	ENOG4105C25	Primosomal protein n'
HM990_RS11420	ENOG4108HRK	Histidine kinase
HM990_RS11425	ENOG4105DY9	regulatoR
HM990_RS11430	ENOG4107U9T	Pfam:Ribonuclease_BN
HM990_RS11435	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HM990_RS11440	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HM990_RS11455	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HM990_RS11480	ENOG4107RJC	Iron-containing alcohol dehydrogenase
HM990_RS11495	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HM990_RS11505	ENOG4105C7H	Helicase, RecD TraA family
HM990_RS11520	ENOG4106H78	methyltransferase
HM990_RS11580	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
HM990_RS11630	ENOG4105EN6	Membrane
HM990_RS11660	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HM990_RS11685	ENOG4108AEY	RNA polymerase sigma factor
HM990_RS11695	ENOG4108RMU	ferritin dps family protein
HM990_RS11700	ENOG4105C5Q	Transcriptional regulator
HM990_RS11755	ENOG4105C3M	thioredoxin reductase
HM990_RS11825	ENOG4105D8V	Glucose sorbosone dehydrogenase
HM990_RS11830	ENOG4107TJ9	Cytochrome
HM990_RS11835	ENOG4105DBI	uridine monophosphokinase
HM990_RS11845	ENOG4105CMN	Methylmalonyl-coA mutase
HM990_RS11855	ENOG4105D5P	Methylmalonyl-coA mutase
HM990_RS11860	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
HM990_RS11865	ENOG4105K6S	Short-chain dehydrogenase reductase Sdr
HM990_RS11870	ENOG4107QJE	Chromosome Partitioning Protein
HM990_RS11875	ENOG4105FA0	parb-like partition protein
HM990_RS11885	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HM990_RS11890	ENOG4105C3F	Signal peptidase i
HM990_RS11920	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HM990_RS11930	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HM990_RS11940	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HM990_RS11985	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HM990_RS11990	ENOG4105SFS	phosphoesterase RecJ domain protein
HM990_RS12000	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
HM990_RS12005	ENOG4105CIN	aminoacyl-histidine dipeptidase
HM990_RS12010	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HM990_RS12035	ENOG4108RWN	rrna methyltransferase
HM990_RS12040	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
HM990_RS12060	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HM990_RS12070	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HM990_RS12080	ENOG4105C8Y	Acetylornithine aminotransferase
HM990_RS12100	ENOG4105E2X	shikimate dehydrogenase
HM990_RS12120	ENOG4105DXN	mazG family
HM990_RS12130	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HM990_RS12135	ENOG4107ZNS	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HM990_RS12140	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HM990_RS12160	ENOG4105JEU	Glycosyl transferase, family 2
HM990_RS12170	ENOG4106WTF	Glycosyl transferase, family 2
HM990_RS12175	ENOG4107BJW	polysaccharide deacetylase
HM990_RS12185	ENOG4106WTF	Glycosyl transferase, family 2
HM990_RS12190	ENOG4108TJN	glycosyl transferase group 1
HM990_RS12205	ENOG4105CAQ	asparagine synthetase
HM990_RS12220	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
HM990_RS12230	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HM990_RS12235	ENOG4107SF2	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
HM990_RS12255	ENOG4105CJ1	ABC, transporter
HM990_RS12295	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HM990_RS12315	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HM990_RS12325	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HM990_RS12385	ENOG4105CSR	polyphosphate kinase 2
HM990_RS12400	ENOG4105EGS	Mechanosensitive ion channel
HM990_RS12405	ENOG4105RHA	ABC transporter, permease
HM990_RS12410	ENOG4108IUX	(ABC) transporter
HM990_RS12415	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HM990_RS12420	ENOG4107XPB	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HM990_RS12435	ENOG4105WH1	Two component transcriptional regulator luxr family
HM990_RS12440	ENOG4105BZU	Histidine kinase
HM990_RS12450	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HM990_RS12465	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HM990_RS12470	ENOG4105ECP	epimerase
HM990_RS12505	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HM990_RS12575	ENOG4108UB4	uncharacterized protein ygjQ
HM990_RS12600	ENOG4108IXY	short-chain dehydrogenase reductase
HM990_RS12625	ENOG4105DG6	mannose-6-phosphate isomerase
HM990_RS12655	ENOG4105D82	Glutamate dehydrogenase
HM990_RS12665	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HM990_RS12675	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HM990_RS12755	ENOG4107UUY	ec 2.7.1.11
HM990_RS12765	ENOG4105ETE	Transcriptional regulator (LacI family
HM990_RS12775	ENOG4105DJB	Major Facilitator Superfamily
HM990_RS12780	ENOG4107YCY	Transcriptional regulator
HM990_RS12815	ENOG4105EY3	heparinase II III family protein
HM990_RS12830	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
HM990_RS12835	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HM990_RS12855	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HM990_RS12860	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HM990_RS12865	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HM990_RS12870	ENOG4107VNI	ribosomal protein l10
HM990_RS12875	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HM990_RS12880	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HM990_RS12885	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HM990_RS12900	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HM990_RS12925	ENOG4105MS2	ribosomal subunit Interface protein
HM990_RS12930	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HM990_RS12935	ENOG4105E5K	Alpha-amylase
HM990_RS12940	ENOG4105C1G	acyl-Coa dehydrogenase
HM990_RS12950	ENOG4105BZG	amino acid carrier protein
HM990_RS12955	ENOG4107SVH	Potassium channel protein
HM990_RS12980	ENOG4105EIG	urea carboxylase-associated protein 1
HM990_RS13030	ENOG4107R34	abc transporter permease protein
HM990_RS13035	ENOG4105EHZ	conserved protein UCP016719
HM990_RS13045	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HM990_RS13065	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HM990_RS13070	ENOG4105EFZ	amidohydrolase
HM990_RS13095	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HM990_RS13125	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
HM990_RS13135	ENOG4105C1J	atp-dependent rna helicase
HM990_RS13145	ENOG4105KNA	-acetyltransferase
HM990_RS13150	ENOG4105FQP	Beta-lactamase
HM990_RS13155	ENOG4108HRK	Histidine kinase
HM990_RS13160	ENOG4108NEV	two component transcriptional regulator, LytTR family
HM990_RS13180	ENOG4105D1Q	UPF0246 protein
HM990_RS13200	ENOG4105C34	Pseudouridine synthase
HM990_RS13210	ENOG4105CPF	Cell wall formation (By similarity)
HM990_RS13215	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HM990_RS13245	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HM990_RS13285	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HM990_RS13305	ENOG4105CDV	Ompa motb domain protein
HM990_RS13315	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HM990_RS13325	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HM990_RS13335	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HM990_RS13345	ENOG4107RE3	peptidase, S41
HM990_RS13365	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HM990_RS13370	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HM990_RS13425	ENOG4105CEY	Amp-dependent synthetase and ligase
HM990_RS13490	ENOG4105C45	hydrogenase expression formation protein (HypE)
HM990_RS13495	ENOG4105CQS	hydrogenase expression formation protein HypD
HM990_RS13510	ENOG4107RSS	Hydrogenase accessory protein HypB
HM990_RS13545	ENOG4105DPX	Hydrogenase, large subunit
HM990_RS13580	ENOG4105E7D	Protein of unknown function (DUF3375)
HM990_RS13620	ENOG4108JUB	Transcriptional regulator
HM990_RS13800	ENOG4105CFG	Acts as a chaperone (By similarity)
HM990_RS13825	ENOG4105D8D	Type III
HM990_RS14000	ENOG4105ETE	Transcriptional regulator (LacI family
HM990_RS14005	ENOG4105CMR	udp-glucose 4-epimerase
HM990_RS14015	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
HM990_RS14020	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HM990_RS14025	ENOG4105CXY	transporter
HM990_RS14030	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HM990_RS14080	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
HM990_RS14095	ENOG4108VCT	Sulfite exporter TauE/SafE
HM990_RS14100	ENOG4105C5X	domain protein
HM990_RS14120	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HM990_RS14155	ENOG4105CP7	Triose-phosphate isomerase
HM990_RS14160	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HM990_RS14175	ENOG4105EEI	dihydropteroate synthase
HM990_RS14195	ENOG4105BZ1	(ABC) transporter
HM990_RS14200	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HM990_RS14215	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HM990_RS14250	ENOG4105C27	TonB-dependent Receptor Plug
HM990_RS14255	ENOG4108HKT	sucrose-6-phosphate hydrolase
HM990_RS14275	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HM990_RS14435	ENOG4105DQ6	Transposase
HM990_RS14505	ENOG410836F	Transposase
HM990_RS14575	ENOG4105C5H	ABC transporter
HM990_RS14585	ENOG4108DNB	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HM990_RS14605	ENOG4105E6M	Sulphatase-modifying factor protein
HM990_RS14630	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HM990_RS14635	ENOG4107WT5	transcriptional regulator (NifA
HM990_RS14660	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HM990_RS14665	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HM990_RS14710	ENOG4105CHR	reductase
HM990_RS14720	ENOG4105EYW	Ion transport protein
HM990_RS14725	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HM990_RS14730	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HM990_RS14735	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HM990_RS14745	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HM990_RS14750	ENOG4105DGW	oligopeptidase A
HM990_RS14795	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HM990_RS14800	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HM990_RS14810	ENOG4107R8N	Glycosyl transferase, family 2
HM990_RS14830	ENOG4105DHJ	ABC, transporter
HM990_RS14855	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HM990_RS14860	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HM990_RS14880	ENOG4105C7S	Dehydrogenase
HM990_RS14890	ENOG4105KG3	cytidine deaminase
HM990_RS14905	ENOG4105E6M	Sulphatase-modifying factor protein
HM990_RS14910	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HM990_RS14915	ENOG4108SQ4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HM990_RS14940	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HM990_RS14950	ENOG4109015	Biopolymer transport protein exbD tolR
HM990_RS14955	ENOG4105M8K	biopolymer transport protein
HM990_RS14960	ENOG4105DN9	Na H antiporter
HM990_RS14970	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HM990_RS14975	ENOG4105C1G	acyl-Coa dehydrogenase
HM990_RS15020	ENOG4107QUV	Domain protein
HM990_RS15075	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HM990_RS15100	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HM990_RS15110	ENOG4105VPI	YqaE family transport protein
HM990_RS15115	ENOG4105WH1	Two component transcriptional regulator luxr family
HM990_RS15125	ENOG4105CRK	lysyL-tRNA synthetase
HM990_RS15165	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HM990_RS15175	ENOG4105K6H	D-cysteine desulfhydrase
HM990_RS15195	ENOG4105CGP	Urocanate hydratase
HM990_RS15205	ENOG4105CHH	sulfate transporter
HM990_RS15210	ENOG4105VEQ	Cold shock protein
HM990_RS15215	ENOG4105KPY	Small multidrug resistance protein
HM990_RS15220	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HM990_RS15225	ENOG4105WH1	Two component transcriptional regulator luxr family
HM990_RS15230	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
HM990_RS15280	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HM990_RS15285	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
HM990_RS15290	ENOG4105N76	Phenylacetate-CoA oxygenase, subunit
HM990_RS15295	ENOG4105D9S	phenylacetate-CoA oxygenase PaaI subunit
HM990_RS15300	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
HM990_RS15305	ENOG4108UKI	Enoyl-CoA hydratase
HM990_RS15315	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HM990_RS15330	ENOG4105CGZ	zinc metallopeptidase
HM990_RS15335	ENOG4105CHU	acetyl-coa acetyltransferase
HM990_RS15340	ENOG4105DXM	phenylacetic acid degradation protein
HM990_RS15365	ENOG4105J0Q	Transcriptional regulator
HM990_RS15370	ENOG4105C7S	Dehydrogenase
HM990_RS15375	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HM990_RS15380	ENOG4105CPP	Dehydrogenase, E1 component
HM990_RS15410	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HM990_RS15415	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HM990_RS15420	ENOG4107S18	3-phosphoshikimate 1-carboxyvinyltransferase
HM990_RS15440	ENOG4105S2T	inner membrane protein YbcI
HM990_RS15445	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HM990_RS15450	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HM990_RS15460	ENOG4105CTQ	phosphohexokinase
HM990_RS15465	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
HM990_RS15475	ENOG4105CHM	Aminotransferase
HM990_RS15480	ENOG4105CQC	Prephenate dehydratase
HM990_RS15485	ENOG4105CJ1	ABC, transporter
HM990_RS15490	ENOG4105C6K	Malic enzyme
HM990_RS15495	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HM990_RS15510	ENOG4105C6T	cysteine synthase
HM990_RS15515	ENOG4105D7W	serine acetyltransferase
HM990_RS15520	ENOG4105CAY	ferredoxin--nadp reductase
HM990_RS15525	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HM990_RS15530	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HM990_RS15545	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
HM990_RS15560	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HM990_RS15565	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
HM990_RS15575	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HM990_RS15585	ENOG4105D9N	nucleoside
HM990_RS15595	ENOG4105C10	Electron transfer flavoprotein
HM990_RS15600	ENOG4105BZJ	Electron transfer flavoprotein
HM990_RS15605	ENOG4105CPP	Dehydrogenase, E1 component
HM990_RS15620	ENOG4105CZ9	Domain of unknown function (DU1801)
HM990_RS15640	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HM990_RS15645	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HM990_RS15675	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HM990_RS15680	ENOG4105C1A	potassium transporter peripheral membrane
HM990_RS15685	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HM990_RS15695	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HM990_RS15705	ENOG4105D2N	Aldolase
HM990_RS15710	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HM990_RS15720	ENOG4105EWM	Histidine kinase
HM990_RS15725	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HM990_RS15730	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HM990_RS15735	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HM990_RS15765	ENOG4108PBI	Polysaccharide metabolism
HM990_RS15770	ENOG4105II7	pyrroline-5-carboxylate reductase
HM990_RS15775	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HM990_RS15780	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HM990_RS15790	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HM990_RS15815	ENOG4105ESV	Glycosyl transferase, family 4
HM990_RS15820	ENOG4107S6X	Glycosyl transferase, family 2
HM990_RS15825	ENOG4108Z90	colanic acid biosynthesis acetyltransferase wcaF
HM990_RS15830	ENOG4108JU4	Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
HM990_RS15865	ENOG4105K64	Glycosyl transferase, family 2
HM990_RS15870	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HM990_RS15880	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HM990_RS15895	ENOG4105K64	Glycosyl transferase, family 2
HM990_RS15915	ENOG4105MFV	ABC-2 type transporter
HM990_RS15920	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HM990_RS15925	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HM990_RS15930	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HM990_RS15935	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HM990_RS15940	ENOG4105C30	Nad-dependent epimerase dehydratase
HM990_RS15945	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
HM990_RS15950	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
HM990_RS15965	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
HM990_RS16020	ENOG4105CBC	glutamate synthase
HM990_RS16025	ENOG4105EM2	membrane
HM990_RS16055	ENOG4105KTH	gatB Yqey
HM990_RS16060	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HM990_RS16065	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HM990_RS16075	ENOG4105DFU	Cell wall formation (By similarity)
HM990_RS16080	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HM990_RS16085	ENOG4105CNI	cell division protein FtsW
HM990_RS16090	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HM990_RS16095	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HM990_RS16100	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HM990_RS16105	ENOG4105CJN	penicillin-binding protein
HM990_RS16115	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HM990_RS16120	ENOG4107YM1	mraZ protein
HM990_RS16130	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HM990_RS16135	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HM990_RS16140	ENOG4105CN1	protease
HM990_RS16145	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HM990_RS16150	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HM990_RS16155	ENOG4107TT5	NLP P60 protein
HM990_RS16160	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
HM990_RS16170	ENOG4105DUX	Transporter
HM990_RS16175	ENOG4105DUX	Transporter
HM990_RS16205	ENOG4105C37	(CBS) domain
HM990_RS16230	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HM990_RS16250	ENOG41090R7	Ferric uptake
HM990_RS16295	ENOG4105C59	p-type ATPase
HM990_RS16300	ENOG4105E3B	Multicopper oxidase
HM990_RS16315	ENOG4108IJF	Heavy metal efflux pump, CzcA
HM990_RS16375	ENOG4107QNK	)-transporter
HM990_RS16390	ENOG4105CBG	Sulfatase
HM990_RS16405	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
HM990_RS16410	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
HM990_RS16465	ENOG4105C01	Dihydroxy-acid dehydratase
HM990_RS16470	ENOG4105C7K	acetolactate synthase
HM990_RS16480	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HM990_RS16485	ENOG4105C7B	Threonine dehydratase
HM990_RS16490	ENOG4105C26	Dehydrogenase
HM990_RS16500	ENOG4105CDH	Citrulline--aspartate ligase
HM990_RS16505	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HM990_RS16515	ENOG4105C8Y	Acetylornithine aminotransferase
HM990_RS16525	ENOG4107T6X	nag kinase
HM990_RS16535	ENOG4105CH7	arginosuccinase
HM990_RS16540	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HM990_RS16545	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HM990_RS16550	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HM990_RS16560	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HM990_RS16570	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HM990_RS16575	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HM990_RS16580	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HM990_RS16585	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HM990_RS16610	ENOG4108YZA	Nitrogen regulatory protein pii
HM990_RS16620	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HM990_RS16630	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HM990_RS16635	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HM990_RS16640	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HM990_RS16655	ENOG4105DWV	Homoserine O-trans-acetylase
HM990_RS16670	ENOG4107Y2X	deaminase
HM990_RS16680	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
HM990_RS16690	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
HM990_RS16715	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
HM990_RS16720	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HM990_RS16755	ENOG4108IFG	nitrite reductase, (NAD(P)H)
HM990_RS16765	ENOG410838F	Glycosyl transferase family 2
HM990_RS16770	ENOG4105CND	Glycosyl transferase, family 2
HM990_RS16795	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
HM990_RS16800	ENOG4105E0R	Deoxyhypusine synthase
HM990_RS16810	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
HM990_RS16815	ENOG4105DY9	regulatoR
HM990_RS16835	ENOG410836F	Transposase
HM990_RS16845	ENOG4105FE9	pseudouridine synthase
HM990_RS16890	ENOG4105BZU	Histidine kinase
HM990_RS16895	ENOG4105CBX	hi0933 family
HM990_RS16915	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
HM990_RS16935	ENOG4105CNG	UPF0061 protein
HM990_RS16960	ENOG4107T9C	Alpha amylase catalytic region
HM990_RS16970	ENOG4108IUM	Glycogen debranching enzyme
HM990_RS16975	ENOG4105CJQ	hydrolase, family 31
HM990_RS16985	ENOG4108IUK	alpha amylase, catalytic
HM990_RS16995	ENOG4107URF	beta-phospho-glucomutase
HM990_RS17005	ENOG4105ETE	Transcriptional regulator (LacI family
HM990_RS17010	ENOG4105C27	TonB-dependent Receptor Plug
HM990_RS17035	ENOG4106FKC	arabinogalactan endo-1,4-beta-galactosidase
HM990_RS17040	ENOG4105K5M	30s ribosomal protein S16
HM990_RS17045	ENOG4107YAY	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HM990_RS17050	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HM990_RS17055	ENOG4105C02	permease
HM990_RS17090	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HM990_RS17095	ENOG4105CD3	dihydroorotase
HM990_RS17105	ENOG4105ECP	epimerase
HM990_RS17110	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HM990_RS17135	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HM990_RS17140	ENOG4105BZU	Histidine kinase
HM990_RS17145	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HM990_RS17150	ENOG4107UGT	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HM990_RS17170	ENOG4105D1F	ATP-binding protein
HM990_RS17175	ENOG41083MR	nifu domain-containing protein
HM990_RS17180	ENOG4105CAY	ferredoxin--nadp reductase
HM990_RS17185	ENOG4108ZIT	Ferredoxin, 2FE-2S
HM990_RS17190	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
HM990_RS17195	ENOG4105M08	Membrane
HM990_RS17205	ENOG4108VVK	transcriptional Regulator, AsnC
HM990_RS17215	ENOG4105CPC	Aldo Keto reductase
HM990_RS17220	ENOG4105ER2	Ompa motb domain protein
HM990_RS17225	ENOG4105CGK	Exodeoxyribonuclease III
HM990_RS17240	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HM990_RS17250	ENOG4105MJ2	Competence protein
HM990_RS17260	ENOG4105CZ7	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
HM990_RS17270	ENOG4105CHM	Aminotransferase
HM990_RS17275	ENOG4105CZH	peptidase
HM990_RS17285	ENOG4108MN8	Membrane
HM990_RS17305	ENOG4105C8T	Leucyl-tRNA synthetase
HM990_RS17310	ENOG4107RJ9	Cell division protein FtsX
HM990_RS17320	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HM990_RS17325	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HM990_RS17340	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HM990_RS17345	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HM990_RS17355	ENOG4107XWI	flavin reductase domain protein, FMN-binding
HM990_RS17360	ENOG4105BZU	Histidine kinase
HM990_RS17365	ENOG4105VC4	domain protein
HM990_RS17380	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HM990_RS17420	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
HM990_RS17430	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HM990_RS17440	ENOG4105C03	ribonuclease
HM990_RS17445	ENOG4105K70	DNA-binding protein
HM990_RS17450	ENOG4105CEN	a g-specific adenine glycosylase
HM990_RS17455	ENOG4108UUM	single-stranded DNA-binding protein
HM990_RS17460	ENOG4105C37	(CBS) domain
HM990_RS17475	ENOG4105C27	TonB-dependent Receptor Plug
HM990_RS17480	ENOG4107QP8	phosphohexose isomerase
HM990_RS17490	ENOG4105HJ8	Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity)
HM990_RS17500	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HM990_RS17510	ENOG4105F1J	Homogentisate 1,2-dioxygenase
HM990_RS17520	ENOG41082MC	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HM990_RS17525	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HM990_RS17540	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HM990_RS17550	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HM990_RS17555	ENOG4107RWD	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HM990_RS17560	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HM990_RS17580	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HM990_RS17590	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HM990_RS17610	ENOG4107T7F	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HM990_RS17615	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HM990_RS17625	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HM990_RS17630	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
HM990_RS17635	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HM990_RS17640	ENOG4105D78	K07001 NTE family protein
HM990_RS17665	ENOG4105C0B	DNA polymerase III (alpha subunit)
HM990_RS17670	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HM990_RS17720	ENOG4107ENK	receptor
HM990_RS17725	ENOG41060VI	Involved in DNA repair and RecF pathway recombination (By similarity)
HM990_RS17735	ENOG4107R37	Glutamate dehydrogenase
HM990_RS17745	ENOG4105C28	cystathionine
HM990_RS17755	ENOG4105EEQ	Na H antiporter
HM990_RS17770	ENOG4108PCN	EamA-like transporter family
HM990_RS17785	ENOG4105DSJ	YicC domain protein
HM990_RS17790	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HM990_RS17795	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HM990_RS17800	ENOG41080R2	UPF0102 protein
HM990_RS17815	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HM990_RS17820	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HM990_RS17830	ENOG4105UYK	outer membrane protein a
HM990_RS17835	ENOG4105BZM	domain protein
HM990_RS17840	ENOG4105DGU	Histone deacetylase
HM990_RS17850	ENOG4108S3W	Anti-feci sigma factor, fecr
HM990_RS17895	ENOG41090A1	ferritin
HM990_RS17950	ENOG410836F	Transposase
HM990_RS17960	ENOG4108UUM	single-stranded DNA-binding protein
HM990_RS17970	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
HM990_RS17975	ENOG4107ZSV	Receptor
HM990_RS18005	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HM990_RS18025	ENOG4105EXW	epimerase dehydratase
HM990_RS18080	ENOG4105DZP	Membrane-associated zinc metalloprotease
HM990_RS18090	ENOG4108KF3	Electron transport protein SCO1 SenC
HM990_RS18100	ENOG4105CE1	Ferrous iron transport protein b
HM990_RS18110	ENOG4107RPQ	ABC transporter
HM990_RS18115	ENOG4105D05	Receptor
HM990_RS18120	ENOG4105DSE	periplasmic solute binding protein
HM990_RS18125	ENOG4105DIK	(ABC) transporter
HM990_RS18130	ENOG4107RPQ	ABC transporter
HM990_RS18135	ENOG4107RBD	ABC, transporter
HM990_RS18140	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HM990_RS18165	ENOG4105CA0	peroxidase
HM990_RS18175	ENOG4108Y6J	UPF0403 protein
HM990_RS18200	ENOG4108R6W	Transcriptional regulator, ARAC family
HM990_RS18235	ENOG4105E39	Enoyl-CoA hydratase
HM990_RS18240	ENOG4108HWS	Histidine kinase
HM990_RS18255	ENOG4107SF0	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HM990_RS18270	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HM990_RS18275	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HM990_RS18285	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HM990_RS18300	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HM990_RS18305	ENOG4105D52	delta-aminolevulinic acid dehydratase
HM990_RS18315	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HM990_RS18320	ENOG4107S1E	Beta-lactamase
HM990_RS18350	ENOG4107QP7	CoA-transferase subunit A
HM990_RS18355	ENOG4108JQC	penicillin-binding protein 1A
HM990_RS18360	ENOG410647Z	gliding motility-associated lipoprotein GldH
HM990_RS18365	ENOG4105MA4	psp1 domain protein
HM990_RS18370	ENOG4105E4C	Lytic transglycosylase catalytic
HM990_RS18380	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HM990_RS18420	ENOG4105NAU	thioesterase Superfamily protein
HM990_RS18445	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HM990_RS18450	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HM990_RS18475	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HM990_RS18480	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HM990_RS18485	ENOG4107Z4P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HM990_RS18490	ENOG4107Z65	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
HM990_RS18495	ENOG4105VHG	atp synthase
HM990_RS18500	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HM990_RS18535	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HM990_RS18550	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HM990_RS18585	ENOG4106CD9	glycosyl transferase group 1
HM990_RS18590	ENOG4108Z90	colanic acid biosynthesis acetyltransferase wcaF
HM990_RS18615	ENOG4105ER6	polysaccharide biosynthesis protein
HM990_RS18625	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HM990_RS18650	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HM990_RS18660	ENOG4105K4H	Nlp p60 protein
HM990_RS18665	ENOG4105BZA	Phosphoglycerate kinase
HM990_RS18670	ENOG4107QRG	dna polymerase iii
HM990_RS18690	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HM990_RS18695	ENOG41080AX	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HM990_RS18705	ENOG4105EEF	Alkane 1-monooxygenase
HM990_RS18710	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HM990_RS18730	ENOG4105DQ6	Transposase
HM990_RS18735	ENOG4105DQ6	Transposase
HM990_RS18755	ENOG4105CX6	glutaminyL-tRNA synthetase
HM990_RS18790	ENOG4105K8R	UPF0145 protein
HM990_RS18795	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HM990_RS18805	ENOG4108YZG	isomerase
HM990_RS18810	ENOG4105PGM	cation diffusion facilitator family transporter
HM990_RS18815	ENOG4107YB6	acetyltransferase, (GNAT) family
HM990_RS18825	ENOG4105CN1	protease
HM990_RS18830	ENOG4105WG6	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HM990_RS18850	ENOG4105C8F	Beta-lactamase domain protein
HM990_RS18860	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
HM990_RS18880	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HM990_RS18895	ENOG4107VAM	peptidase, m28
HM990_RS18925	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HM990_RS18930	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HM990_RS18935	ENOG4105D60	lipoprotein releasing system transmembrane protein
HM990_RS18940	ENOG4105H4N	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HM990_RS18945	ENOG4108ZVT	methylmalonyl-coA epimerase
HM990_RS18960	ENOG4105DMW	Dehydrogenase reductase
HM990_RS18965	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HM990_RS18985	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HM990_RS18990	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HM990_RS18995	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HM990_RS19005	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HM990_RS19030	ENOG4105Y49	secretion protein, HlyD family
HM990_RS19035	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HM990_RS19045	ENOG4105ESV	Glycosyl transferase, family 4
HM990_RS19050	ENOG4105C5E	polysaccharide biosynthesis protein
HM990_RS19055	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HM990_RS19065	ENOG4105CPC	Aldo Keto reductase
HM990_RS19105	ENOG4105ECJ	Glycosyl Transferase
HM990_RS19125	ENOG4105K64	Glycosyl transferase, family 2
HM990_RS19135	ENOG4105D75	Capsular exopolysaccharide family
HM990_RS19150	ENOG4108R6K	riboflavin synthase, subunit alpha
HM990_RS19155	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HM990_RS19165	ENOG4105WXV	50S ribosomal protein L32
HM990_RS19170	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HM990_RS19175	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HM990_RS19180	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HM990_RS19195	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
HM990_RS19205	ENOG4108YYC	ycei family
HM990_RS19220	ENOG41065KQ	synthase
HM990_RS19225	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HM990_RS19235	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HM990_RS19250	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HM990_RS19265	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HM990_RS19270	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HM990_RS19275	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HM990_RS19280	ENOG4107T8J	thymidine kinase
HM990_RS19300	ENOG4108RG0	uracil-dna glycosylase
HM990_RS19330	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HM990_RS19345	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HM990_RS19350	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
HM990_RS19400	ENOG4105BZU	Histidine kinase
HM990_RS19420	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HM990_RS19425	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HM990_RS19435	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HM990_RS19440	ENOG4105DWF	phosphomethylpyrimidine kinase
HM990_RS19460	ENOG4108B1Q	Ribonuclease
HM990_RS19470	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HM990_RS19475	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HM990_RS19480	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HM990_RS19490	ENOG4105CA9	Pyruvate kinase
HM990_RS19520	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HM990_RS19525	ENOG4108JQC	penicillin-binding protein 1A
HM990_RS19545	ENOG4105VG1	fes assembly suf system protein
HM990_RS19550	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
HM990_RS19560	ENOG4105C9B	Cysteine desulfurase
HM990_RS19610	ENOG4108Z4V	iron-sulfur cluster assembly
HM990_RS19620	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HM990_RS19645	ENOG4105CFH	Aspartokinase
HM990_RS19665	ENOG4105DC7	peptidase M24
HM990_RS19690	ENOG4105E33	succinate dehydrogenase
HM990_RS19705	ENOG4105K46	50S ribosomal protein l27
HM990_RS19710	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HM990_RS19725	ENOG4108594	Permease of the drug metabolite transporter
HM990_RS19730	ENOG4105XIV	Mercuric transport protein, periplasmic component
HM990_RS19765	ENOG4108JQB	penicillin-binding protein 1C