locus-tag	class	description
HM990_RS00015	COG2329	Antibiotic biosynthesis monooxygenase
HM990_RS00070	COG1012	belongs to the aldehyde dehydrogenase family
HM990_RS00095	COG4989	oxidoreductase activity
HM990_RS00105	COG0714	Associated with various cellular activities
HM990_RS00120	COG2304	oxidoreductase activity
HM990_RS00170	COG0659	secondary active sulfate transmembrane transporter activity
HM990_RS00175	COG0288	reversible hydration of carbon dioxide
HM990_RS00190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HM990_RS00205	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HM990_RS00215	COG1652	LysM domain
HM990_RS00230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HM990_RS00240	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HM990_RS00250	COG0527	aspartate kinase activity
HM990_RS00280	COG2197	response regulator
HM990_RS00285	COG1233	COG1233 Phytoene dehydrogenase and related
HM990_RS00290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM990_RS00300	COG2239	Acts as a magnesium transporter
HM990_RS00305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HM990_RS00320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HM990_RS00330	COG0196	riboflavin kinase activity
HM990_RS00340	COG0193	aminoacyl-tRNA hydrolase activity
HM990_RS00345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HM990_RS00350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HM990_RS00360	COG1475	DNA binding
HM990_RS00485	COG2226	methyltransferase
HM990_RS00545	COG0629	single-stranded DNA binding
HM990_RS00630	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM990_RS00635	COG1104	cysteine desulfurase activity
HM990_RS00675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HM990_RS00695	COG2814	Major facilitator Superfamily
HM990_RS00700	COG2217	Heavy metal translocating P-type atpase
HM990_RS00715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HM990_RS00725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HM990_RS00750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM990_RS00755	COG3174	membrane
HM990_RS00760	COG0205	6-phosphofructokinase activity
HM990_RS00770	COG1301	dicarboxylic acid transport
HM990_RS00775	COG1830	Aldolase
HM990_RS00860	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HM990_RS00870	COG2132	Multicopper oxidase
HM990_RS00905	COG0701	Predicted permease
HM990_RS00920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM990_RS00930	COG2207	Transcriptional regulator
HM990_RS00955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HM990_RS00975	COG2217	Heavy metal translocating P-type atpase
HM990_RS01000	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HM990_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS01010	COG1904	glucuronate isomerase
HM990_RS01015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HM990_RS01030	COG0246	Mannitol dehydrogenase
HM990_RS01035	COG2721	sulfolactate sulfo-lyase activity
HM990_RS01065	COG4771	TonB-dependent receptor
HM990_RS01100	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HM990_RS01105	COG0673	inositol 2-dehydrogenase activity
HM990_RS01125	COG2755	lipolytic protein G-D-S-L family
HM990_RS01130	COG2755	lipolytic protein G-D-S-L family
HM990_RS01130	COG0657	acetylesterase activity
HM990_RS01140	COG0303	'Molybdopterin
HM990_RS01155	COG0746	molybdenum cofactor guanylyltransferase activity
HM990_RS01160	COG1648	precorrin-2 dehydrogenase activity
HM990_RS01160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HM990_RS01175	COG0314	molybdopterin synthase activity
HM990_RS01185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HM990_RS01190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM990_RS01195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HM990_RS01205	COG1410	methionine synthase
HM990_RS01205	COG0646	methionine synthase
HM990_RS01225	COG0793	Belongs to the peptidase S41A family
HM990_RS01275	COG2095	MarC family integral membrane protein
HM990_RS01290	COG3275	phosphorelay sensor kinase activity
HM990_RS01295	COG3279	Response regulator of the LytR AlgR family
HM990_RS01300	COG1328	CTP reductase activity
HM990_RS01300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HM990_RS01305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HM990_RS01335	COG1629	transport
HM990_RS01345	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HM990_RS01355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HM990_RS01365	COG0590	tRNA wobble adenosine to inosine editing
HM990_RS01400	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HM990_RS01450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HM990_RS01455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HM990_RS01475	COG2315	Protein conserved in bacteria
HM990_RS01480	COG0784	Response regulator, receiver
HM990_RS01490	COG4251	negative regulation of phosphorylation
HM990_RS01500	COG5002	protein histidine kinase activity
HM990_RS01510	COG3279	Response regulator of the LytR AlgR family
HM990_RS01570	COG1482	cell wall glycoprotein biosynthetic process
HM990_RS01575	COG2824	Alkylphosphonate utilization operon protein PhnA
HM990_RS01605	COG1278	Cold shock
HM990_RS01620	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HM990_RS01625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HM990_RS01640	COG1309	transcriptional regulator
HM990_RS01655	COG1959	2 iron, 2 sulfur cluster binding
HM990_RS01660	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HM990_RS01720	COG4263	nitrous-oxide reductase activity
HM990_RS01725	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM990_RS01745	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM990_RS01760	COG0084	hydrolase, TatD family'
HM990_RS01765	COG0252	asparaginase activity
HM990_RS01775	COG0811	peptide transport
HM990_RS01810	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HM990_RS01815	COG0017	Asparaginyl-tRNA synthetase
HM990_RS01830	COG0233	cytoplasmic translational termination
HM990_RS01835	COG0528	UMP kinase activity
HM990_RS01840	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HM990_RS01845	COG0052	Belongs to the universal ribosomal protein uS2 family
HM990_RS01850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HM990_RS01855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HM990_RS01860	COG0589	response to stress
HM990_RS01865	COG0009	L-threonylcarbamoyladenylate synthase
HM990_RS01880	COG0488	(ABC) transporter
HM990_RS01885	COG1032	radical SAM domain protein
HM990_RS01895	COG2852	Protein conserved in bacteria
HM990_RS01905	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HM990_RS01910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM990_RS01910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM990_RS01930	COG3292	Two component regulator propeller
HM990_RS01930	COG2205	protein histidine kinase activity
HM990_RS01930	COG0745	RESPONSE REGULATOR receiver
HM990_RS01950	COG3279	Response regulator of the LytR AlgR family
HM990_RS01965	COG3118	belongs to the thioredoxin family
HM990_RS01990	COG0779	Required for maturation of 30S ribosomal subunits
HM990_RS01995	COG0195	Participates in both transcription termination and antitermination
HM990_RS02000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HM990_RS02020	COG0437	4 iron, 4 sulfur cluster binding
HM990_RS02025	COG3743	rRNA binding
HM990_RS02025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HM990_RS02045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HM990_RS02050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HM990_RS02055	COG2255	four-way junction helicase activity
HM990_RS02060	COG2124	cytochrome p450
HM990_RS02065	COG1858	cytochrome C peroxidase
HM990_RS02070	COG3292	Two component regulator propeller
HM990_RS02070	COG2205	protein histidine kinase activity
HM990_RS02070	COG0745	RESPONSE REGULATOR receiver
HM990_RS02085	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HM990_RS02090	COG1609	Transcriptional regulator
HM990_RS02105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HM990_RS02110	COG0366	Alpha amylase catalytic
HM990_RS02125	COG0281	malic enzyme
HM990_RS02125	COG0280	phosphate acetyltransferase
HM990_RS02130	COG0632	four-way junction helicase activity
HM990_RS02140	COG0509	glycine decarboxylation via glycine cleavage system
HM990_RS02200	COG0109	protoheme IX farnesyltransferase activity
HM990_RS02205	COG1845	cytochrome c oxidase, subunit III
HM990_RS02225	COG1999	signal sequence binding
HM990_RS02230	COG2322	membrane
HM990_RS02240	COG1136	(ABC) transporter
HM990_RS02245	COG0577	efflux transmembrane transporter activity
HM990_RS02245	COG1136	(ABC) transporter
HM990_RS02250	COG0577	efflux transmembrane transporter activity
HM990_RS02250	COG1136	(ABC) transporter
HM990_RS02255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM990_RS02275	COG0668	transmembrane transport
HM990_RS02290	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HM990_RS02315	COG2972	Histidine kinase
HM990_RS02315	COG0745	RESPONSE REGULATOR receiver
HM990_RS02345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HM990_RS02350	COG0740	serine-type endopeptidase activity
HM990_RS02355	COG0544	peptidyl-prolyl cis-trans isomerase activity
HM990_RS02370	COG0596	Alpha beta hydrolase
HM990_RS02375	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HM990_RS02385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HM990_RS02395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HM990_RS02415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HM990_RS02425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HM990_RS02430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HM990_RS02450	COG1428	Deoxynucleoside kinase
HM990_RS02460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM990_RS02465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HM990_RS02495	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS02500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM990_RS02505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM990_RS02520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM990_RS02530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM990_RS02545	COG1131	(ABC) transporter
HM990_RS02575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM990_RS02580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM990_RS02610	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM990_RS02620	COG0463	Glycosyl transferase, family 2
HM990_RS02645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HM990_RS02660	COG4771	TonB-dependent receptor
HM990_RS02665	COG0702	epimerase
HM990_RS02710	COG2211	Major facilitator Superfamily
HM990_RS02760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HM990_RS02765	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HM990_RS02775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HM990_RS02780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HM990_RS02785	COG0110	maltose O-acetyltransferase activity
HM990_RS02790	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HM990_RS02795	COG3174	membrane
HM990_RS02805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HM990_RS02810	COG1428	Deoxynucleoside kinase
HM990_RS02850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM990_RS02865	COG1012	belongs to the aldehyde dehydrogenase family
HM990_RS02875	COG2967	ApaG domain
HM990_RS02895	COG1805	sodium ion transport
HM990_RS02900	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HM990_RS02935	COG0531	amino acid
HM990_RS02940	COG2311	Membrane
HM990_RS02945	COG2311	Membrane
HM990_RS02950	COG2267	carboxylic ester hydrolase activity
HM990_RS02995	COG1477	protein flavinylation
HM990_RS03015	COG0427	acetyl-CoA hydrolase
HM990_RS03025	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HM990_RS03040	COG3340	Belongs to the peptidase S51 family
HM990_RS03065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HM990_RS03090	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS03105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HM990_RS03110	COG3844	kynureninase activity
HM990_RS03115	COG2205	protein histidine kinase activity
HM990_RS03115	COG0784	Response regulator, receiver
HM990_RS03140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HM990_RS03145	COG1663	tetraacyldisaccharide 4'-kinase activity
HM990_RS03150	COG2205	protein histidine kinase activity
HM990_RS03150	COG0784	Response regulator, receiver
HM990_RS03155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HM990_RS03160	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HM990_RS03190	COG1595	DNA-templated transcription, initiation
HM990_RS03195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HM990_RS03200	COG0436	Aminotransferase
HM990_RS03215	COG0525	valine-tRNA ligase activity
HM990_RS03220	COG0772	Belongs to the SEDS family
HM990_RS03225	COG0768	penicillin binding
HM990_RS03240	COG1077	Cell shape determining protein MreB Mrl
HM990_RS03245	COG0138	bifunctional purine biosynthesis protein purh
HM990_RS03255	COG2373	Large extracellular alpha-helical protein
HM990_RS03285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HM990_RS03330	COG2003	Belongs to the UPF0758 family
HM990_RS03340	COG1011	Hydrolase
HM990_RS03350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HM990_RS03360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM990_RS03385	COG1629	transport
HM990_RS03395	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HM990_RS03400	COG0049	tRNA binding
HM990_RS03405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HM990_RS03410	COG0051	transcription antitermination factor activity, RNA binding
HM990_RS03415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HM990_RS03420	COG0088	Forms part of the polypeptide exit tunnel
HM990_RS03425	COG0089	rRNA binding
HM990_RS03430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HM990_RS03435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HM990_RS03440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HM990_RS03445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HM990_RS03450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HM990_RS03455	COG0255	Belongs to the universal ribosomal protein uL29 family
HM990_RS03460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HM990_RS03465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HM990_RS03470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HM990_RS03475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HM990_RS03480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HM990_RS03485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HM990_RS03490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HM990_RS03495	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HM990_RS03500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HM990_RS03505	COG1841	ribosomal large subunit assembly
HM990_RS03510	COG0200	Binds to the 23S rRNA
HM990_RS03515	COG0201	protein transport
HM990_RS03520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HM990_RS03525	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HM990_RS03530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HM990_RS03535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HM990_RS03540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HM990_RS03545	COG0202	RNA polymerase activity
HM990_RS03550	COG0203	ribosomal protein L17
HM990_RS03560	COG0148	phosphopyruvate hydratase activity
HM990_RS03600	COG0688	phosphatidylethanolamine metabolic process
HM990_RS03605	COG4589	Belongs to the CDS family
HM990_RS03615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HM990_RS03620	COG0799	negative regulation of ribosome biogenesis
HM990_RS03635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HM990_RS03655	COG0189	ligase activity
HM990_RS03690	COG5002	protein histidine kinase activity
HM990_RS03695	COG0018	arginyl-trna synthetase
HM990_RS03720	COG3712	iron ion homeostasis
HM990_RS03745	COG0433	COG0433 Predicted ATPase
HM990_RS03755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HM990_RS03755	COG0662	Cupin 2, conserved barrel domain protein
HM990_RS03785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HM990_RS03795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HM990_RS03800	COG0602	queuosine metabolic process
HM990_RS03810	COG0367	asparagine synthase
HM990_RS03815	COG0187	DNA topoisomerase II activity
HM990_RS03850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HM990_RS03870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HM990_RS03875	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HM990_RS03880	COG0215	cysteine-tRNA ligase activity
HM990_RS03885	COG0302	gtp cyclohydrolase
HM990_RS03910	COG0442	prolyl-tRNA aminoacylation
HM990_RS03920	COG0268	Binds directly to 16S ribosomal RNA
HM990_RS03930	COG0673	inositol 2-dehydrogenase activity
HM990_RS03945	COG0784	Response regulator, receiver
HM990_RS03950	COG4251	negative regulation of phosphorylation
HM990_RS03990	COG2356	endonuclease I
HM990_RS04000	COG0174	glutamine synthetase
HM990_RS04020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HM990_RS04035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HM990_RS04040	COG0284	orotidine-5'-phosphate decarboxylase activity
HM990_RS04045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HM990_RS04060	COG0788	formyltetrahydrofolate deformylase activity
HM990_RS04065	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM990_RS04065	COG1703	isobutyryl-CoA mutase activity
HM990_RS04065	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM990_RS04085	COG1522	sequence-specific DNA binding
HM990_RS04095	COG0492	ferredoxin-NADP+ reductase activity
HM990_RS04105	COG2814	Major facilitator Superfamily
HM990_RS04120	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HM990_RS04150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HM990_RS04160	COG0463	Glycosyl transferase, family 2
HM990_RS04175	COG2244	polysaccharide biosynthetic process
HM990_RS04205	COG0463	Glycosyl transferase, family 2
HM990_RS04205	COG1216	Glycosyl transferase, family 2
HM990_RS04210	COG1216	Glycosyl transferase, family 2
HM990_RS04210	COG0463	Glycosyl transferase, family 2
HM990_RS04220	COG2884	Cell division ATP-binding protein ftsE
HM990_RS04230	COG0133	tryptophan synthase activity
HM990_RS04235	COG0135	phosphoribosylanthranilate isomerase activity
HM990_RS04240	COG0134	indole-3-glycerol-phosphate synthase activity
HM990_RS04245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HM990_RS04250	COG0512	Glutamine amidotransferase of anthranilate synthase
HM990_RS04255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HM990_RS04265	COG1846	Transcriptional regulator
HM990_RS04280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HM990_RS04320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM990_RS04325	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM990_RS04330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM990_RS04360	COG2197	response regulator
HM990_RS04365	COG2201	protein-glutamate methylesterase activity
HM990_RS04375	COG1047	Peptidyl-prolyl cis-trans
HM990_RS04385	COG1349	DNA-binding transcription factor activity
HM990_RS04390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HM990_RS04400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HM990_RS04410	COG4771	TonB-dependent receptor
HM990_RS04440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HM990_RS04455	COG2885	chlorophyll binding
HM990_RS04460	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HM990_RS04500	COG1073	alpha beta
HM990_RS04525	COG1595	DNA-templated transcription, initiation
HM990_RS04535	COG0513	Belongs to the DEAD box helicase family
HM990_RS04540	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HM990_RS04560	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HM990_RS04565	COG2258	MOSC domain
HM990_RS04585	COG1629	transport
HM990_RS04590	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM990_RS04600	COG0326	Molecular chaperone. Has ATPase activity
HM990_RS04605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM990_RS04615	COG3609	addiction module antidote protein, CC2985 family
HM990_RS04640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM990_RS04655	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HM990_RS04665	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM990_RS04670	COG1902	pentaerythritol trinitrate reductase activity
HM990_RS04675	COG0450	alkyl hydroperoxide reductase
HM990_RS04695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HM990_RS04700	COG0179	Fumarylacetoacetate (FAA) hydrolase
HM990_RS04710	COG1058	Belongs to the CinA family
HM990_RS04710	COG1546	Belongs to the CinA family
HM990_RS04715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HM990_RS04720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HM990_RS04730	COG0552	protein localization to endoplasmic reticulum
HM990_RS04740	COG0154	amidase activity
HM990_RS04750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM990_RS04765	COG0656	L-ascorbic acid biosynthetic process
HM990_RS04810	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HM990_RS04815	COG0076	glutamate decarboxylase activity
HM990_RS04855	COG0519	Catalyzes the synthesis of GMP from XMP
HM990_RS04855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HM990_RS04900	COG0504	CTP synthase activity
HM990_RS04905	COG0706	membrane insertase activity
HM990_RS04910	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM990_RS04920	COG0482	sulfurtransferase activity
HM990_RS04965	COG0534	Mate efflux family protein
HM990_RS04975	COG0671	phosphoesterase, PA-phosphatase related
HM990_RS04980	COG0671	phosphoesterase, PA-phosphatase related
HM990_RS04990	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM990_RS04990	COG3952	Lipid A Biosynthesis
HM990_RS04995	COG0463	Glycosyl transferase, family 2
HM990_RS05005	COG1595	DNA-templated transcription, initiation
HM990_RS05050	COG3275	phosphorelay sensor kinase activity
HM990_RS05070	COG3279	Response regulator of the LytR AlgR family
HM990_RS05125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HM990_RS05130	COG0589	response to stress
HM990_RS05155	COG0348	domain, Protein
HM990_RS05160	COG2010	Cytochrome c
HM990_RS05170	COG3278	Belongs to the heme-copper respiratory oxidase family
HM990_RS05185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HM990_RS05305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HM990_RS05315	COG1191	sigma factor activity
HM990_RS05325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM990_RS05355	COG1104	cysteine desulfurase activity
HM990_RS05390	COG1418	mRNA catabolic process
HM990_RS05415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HM990_RS05425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HM990_RS05440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM990_RS05445	COG0297	glycogen (starch) synthase activity
HM990_RS05450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HM990_RS05455	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HM990_RS05460	COG3387	PFAM Glycoside hydrolase 15-related
HM990_RS05465	COG0366	Alpha amylase catalytic
HM990_RS05475	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HM990_RS05485	COG0542	response to heat
HM990_RS05500	COG0791	NLP P60 protein
HM990_RS05505	COG0183	Belongs to the thiolase family
HM990_RS05510	COG1480	7TM receptor with intracellular HD hydrolase
HM990_RS05535	COG1793	dna ligase
HM990_RS05535	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HM990_RS05555	COG0628	permease
HM990_RS05585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HM990_RS05595	COG0205	6-phosphofructokinase activity
HM990_RS05625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HM990_RS05645	COG1741	Belongs to the pirin family
HM990_RS05655	COG0488	(ABC) transporter
HM990_RS05715	COG0010	Belongs to the arginase family
HM990_RS05725	COG1228	amidohydrolase
HM990_RS05755	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HM990_RS05770	COG2988	succinylglutamate desuccinylase activity
HM990_RS05775	COG0516	GMP reductase activity
HM990_RS05775	COG0517	IMP dehydrogenase activity
HM990_RS05785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HM990_RS05790	COG2382	esterase
HM990_RS05810	COG1136	(ABC) transporter
HM990_RS05820	COG4771	TonB-dependent receptor
HM990_RS05850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM990_RS05855	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HM990_RS05865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HM990_RS05905	COG3547	Transposase (IS116 IS110 IS902 family)
HM990_RS05930	COG0366	Alpha amylase catalytic
HM990_RS05935	COG3119	arylsulfatase activity
HM990_RS05940	COG3547	Transposase (IS116 IS110 IS902 family)
HM990_RS05955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM990_RS06025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HM990_RS06030	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HM990_RS06040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HM990_RS06055	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HM990_RS06065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HM990_RS06070	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HM990_RS06075	COG0824	Thioesterase
HM990_RS06080	COG1739	Uncharacterized protein family UPF0029
HM990_RS06085	COG0697	spore germination
HM990_RS06090	COG1011	Hydrolase
HM990_RS06095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HM990_RS06095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HM990_RS06110	COG2890	protein-(glutamine-N5) methyltransferase activity
HM990_RS06115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HM990_RS06125	COG0737	Belongs to the 5'-nucleotidase family
HM990_RS06140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HM990_RS06165	COG0497	DNA recombination
HM990_RS06180	COG0463	Glycosyl transferase, family 2
HM990_RS06180	COG1216	Glycosyl transferase, family 2
HM990_RS06190	COG0237	dephospho-CoA kinase activity
HM990_RS06210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HM990_RS06215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HM990_RS06225	COG2176	DNA-directed DNA polymerase activity
HM990_RS06245	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM990_RS06250	COG0673	inositol 2-dehydrogenase activity
HM990_RS06255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HM990_RS06260	COG2936	dipeptidyl-peptidase activity
HM990_RS06280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HM990_RS06300	COG0813	purine-nucleoside phosphorylase activity
HM990_RS06305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HM990_RS06315	COG0542	response to heat
HM990_RS06340	COG0564	pseudouridine synthase activity
HM990_RS06350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HM990_RS06390	COG0300	oxidoreductase activity
HM990_RS06400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HM990_RS06410	COG0488	(ABC) transporter
HM990_RS06425	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HM990_RS06430	COG2207	Transcriptional regulator
HM990_RS06430	COG1917	Cupin 2, conserved barrel domain protein
HM990_RS06445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM990_RS06450	COG0450	alkyl hydroperoxide reductase
HM990_RS06465	COG0626	cystathionine gamma-synthase activity
HM990_RS06480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HM990_RS06485	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HM990_RS06495	COG3279	Response regulator of the LytR AlgR family
HM990_RS06500	COG3275	phosphorelay sensor kinase activity
HM990_RS06515	COG1595	DNA-templated transcription, initiation
HM990_RS06525	COG0668	transmembrane transport
HM990_RS06530	COG0513	Belongs to the DEAD box helicase family
HM990_RS06540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HM990_RS06555	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HM990_RS06560	COG1012	belongs to the aldehyde dehydrogenase family
HM990_RS06565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HM990_RS06570	COG1953	Uracil, thiamine, allantoin
HM990_RS06585	COG0493	'glutamate synthase
HM990_RS06590	COG0167	dihydroorotate dehydrogenase activity
HM990_RS06590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HM990_RS06600	COG0429	hydrolase of the alpha beta-hydrolase fold
HM990_RS06625	COG0606	chelatase, subunit chli
HM990_RS06655	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HM990_RS06660	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HM990_RS06680	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HM990_RS06690	COG0778	Nitroreductase
HM990_RS06695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM990_RS06705	COG3292	Two component regulator propeller
HM990_RS06705	COG2205	protein histidine kinase activity
HM990_RS06705	COG0745	RESPONSE REGULATOR receiver
HM990_RS06755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM990_RS06755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM990_RS06770	COG1674	ftsk spoiiie
HM990_RS06785	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HM990_RS06815	COG0598	Magnesium transport protein CorA
HM990_RS06830	COG0424	maF-like protein
HM990_RS06865	COG1970	mechanosensitive ion channel activity
HM990_RS06870	COG1333	cytochrome c biogenesis protein
HM990_RS06870	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HM990_RS06875	COG0626	cystathionine gamma-synthase activity
HM990_RS06885	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HM990_RS06890	COG0490	domain, Protein
HM990_RS06890	COG0471	metal ion transport
HM990_RS06895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HM990_RS06930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM990_RS06965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HM990_RS06970	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HM990_RS06980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HM990_RS06995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HM990_RS07000	COG3959	Transketolase, thiamine diphosphate binding domain
HM990_RS07005	COG0343	queuine tRNA-ribosyltransferase activity
HM990_RS07020	COG0825	malonyl-CoA metabolic process
HM990_RS07025	COG0305	Participates in initiation and elongation during chromosome replication
HM990_RS07065	COG0561	phosphatase activity
HM990_RS07070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HM990_RS07075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HM990_RS07080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HM990_RS07085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HM990_RS07115	COG0564	pseudouridine synthase activity
HM990_RS07120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HM990_RS07125	COG1760	l-serine dehydratase
HM990_RS07135	COG0443	Heat shock 70 kDa protein
HM990_RS07150	COG2986	histidine ammonia-lyase
HM990_RS07210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HM990_RS07215	COG1388	LysM domain
HM990_RS07215	COG0791	NLP P60 protein
HM990_RS07225	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HM990_RS07240	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HM990_RS07245	COG0540	Belongs to the ATCase OTCase family
HM990_RS07255	COG1234	tRNA 3'-trailer cleavage
HM990_RS07265	COG0259	pyridoxamine-phosphate oxidase activity
HM990_RS07300	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HM990_RS07315	COG2234	aminopeptidase activity
HM990_RS07320	COG2234	aminopeptidase activity
HM990_RS07335	COG4974	Belongs to the 'phage' integrase family
HM990_RS07350	COG3177	Filamentation induced by cAMP protein fic
HM990_RS07360	COG3119	arylsulfatase activity
HM990_RS07370	COG3119	arylsulfatase activity
HM990_RS07380	COG1069	ribulokinase activity
HM990_RS07385	COG0738	Major facilitator superfamily
HM990_RS07445	COG1136	(ABC) transporter
HM990_RS07450	COG4591	ABC-type transport system involved in lipoprotein release permease component
HM990_RS07460	COG0517	IMP dehydrogenase activity
HM990_RS07460	COG1994	Peptidase M50
HM990_RS07470	COG2202	Pas domain
HM990_RS07470	COG1366	Belongs to the anti-sigma-factor antagonist family
HM990_RS07495	COG0589	response to stress
HM990_RS07515	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HM990_RS07535	COG0589	response to stress
HM990_RS07560	COG0335	large ribosomal subunit rRNA binding
HM990_RS07565	COG0336	Belongs to the RNA methyltransferase TrmD family
HM990_RS07570	COG0095	Lipoate-protein ligase
HM990_RS07575	COG0596	Alpha beta hydrolase
HM990_RS07585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM990_RS07610	COG1252	NADH dehydrogenase
HM990_RS07630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HM990_RS07640	COG0798	PFAM Bile acid sodium symporter
HM990_RS07675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HM990_RS07685	COG0083	homoserine kinase activity
HM990_RS07690	COG0460	homoserine dehydrogenase
HM990_RS07690	COG0527	aspartate kinase activity
HM990_RS07695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HM990_RS07700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM990_RS07705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HM990_RS07765	COG0793	Belongs to the peptidase S41A family
HM990_RS07765	COG4946	Tricorn protease homolog
HM990_RS07770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HM990_RS07780	COG2996	Protein conserved in bacteria
HM990_RS07795	COG1575	Belongs to the MenA family. Type 1 subfamily
HM990_RS07800	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HM990_RS07820	COG4948	Mandelate Racemase Muconate Lactonizing
HM990_RS07835	COG2304	oxidoreductase activity
HM990_RS07845	COG3275	phosphorelay sensor kinase activity
HM990_RS07850	COG3279	Response regulator of the LytR AlgR family
HM990_RS07855	COG3547	Transposase (IS116 IS110 IS902 family)
HM990_RS07865	COG0012	GTP binding
HM990_RS07875	COG0697	spore germination
HM990_RS07910	COG0861	Integral membrane protein TerC family
HM990_RS07930	COG1522	sequence-specific DNA binding
HM990_RS07940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HM990_RS07945	COG0506	proline dehydrogenase activity
HM990_RS07965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM990_RS07980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM990_RS07990	COG0367	asparagine synthase
HM990_RS07995	COG0438	transferase activity, transferring glycosyl groups
HM990_RS08010	COG1216	Glycosyl transferase, family 2
HM990_RS08030	COG1216	Glycosyl transferase, family 2
HM990_RS08040	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HM990_RS08070	COG0802	atpase or kinase
HM990_RS08075	COG2204	response regulator
HM990_RS08080	COG1078	dGTPase activity
HM990_RS08085	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM990_RS08090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM990_RS08090	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HM990_RS08095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM990_RS08100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HM990_RS08115	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HM990_RS08120	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS08145	COG0101	tRNA pseudouridine synthase activity
HM990_RS08165	COG0783	Belongs to the Dps family
HM990_RS08170	COG0668	transmembrane transport
HM990_RS08195	COG2135	peptidase activity
HM990_RS08205	COG0668	transmembrane transport
HM990_RS08210	COG2814	Major facilitator Superfamily
HM990_RS08220	COG1278	Cold shock
HM990_RS08225	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM990_RS08245	COG4942	peptidase
HM990_RS08255	COG0484	heat shock protein binding
HM990_RS08260	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS08275	COG0513	Belongs to the DEAD box helicase family
HM990_RS08290	COG1278	Cold shock
HM990_RS08310	COG1012	belongs to the aldehyde dehydrogenase family
HM990_RS08315	COG4221	oxidoreductase activity
HM990_RS08325	COG1902	pentaerythritol trinitrate reductase activity
HM990_RS08405	COG4251	negative regulation of phosphorylation
HM990_RS08455	COG1309	transcriptional regulator
HM990_RS08460	COG0702	epimerase
HM990_RS08470	COG2130	NADP-dependent
HM990_RS08475	COG1979	alcohol dehydrogenase
HM990_RS08495	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM990_RS08500	COG0543	2 iron, 2 sulfur cluster binding
HM990_RS08500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HM990_RS08520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HM990_RS08540	COG1703	isobutyryl-CoA mutase activity
HM990_RS08550	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM990_RS08550	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM990_RS08555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM990_RS08560	COG0427	acetyl-CoA hydrolase
HM990_RS08565	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HM990_RS08570	COG4770	biotin carboxylase activity
HM990_RS08580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HM990_RS08585	COG0346	lactoylglutathione lyase activity
HM990_RS08590	COG1960	acyl-CoA dehydrogenase activity
HM990_RS08615	COG2197	response regulator
HM990_RS08635	COG2130	NADP-dependent
HM990_RS08665	COG2066	Belongs to the glutaminase family
HM990_RS08675	COG2307	Protein conserved in bacteria
HM990_RS08675	COG2308	Evidence 4 Homologs of previously reported genes of
HM990_RS08700	COG2308	Evidence 4 Homologs of previously reported genes of
HM990_RS08710	COG2176	DNA-directed DNA polymerase activity
HM990_RS08715	COG1196	nuclear chromosome segregation
HM990_RS08715	COG3264	Mechanosensitive ion channel
HM990_RS08720	COG3237	CsbD-like
HM990_RS08730	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HM990_RS08735	COG4181	ATPase activity
HM990_RS08755	COG0668	transmembrane transport
HM990_RS08830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HM990_RS08850	COG1187	pseudouridine synthase activity
HM990_RS08860	COG2897	thiosulfate sulfurtransferase activity
HM990_RS08865	COG1301	dicarboxylic acid transport
HM990_RS08870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HM990_RS08880	COG0277	FAD linked oxidase domain protein
HM990_RS08880	COG0247	lactate metabolic process
HM990_RS08930	COG2323	membrane
HM990_RS08935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HM990_RS08945	COG2154	pterin-4-alpha-carbinolamine dehydratase
HM990_RS08950	COG0217	transcriptional regulatory protein
HM990_RS08970	COG0673	inositol 2-dehydrogenase activity
HM990_RS08995	COG0702	epimerase
HM990_RS09005	COG0415	Belongs to the DNA photolyase family
HM990_RS09010	COG3046	protein related to deoxyribodipyrimidine photolyase
HM990_RS09015	COG0415	Belongs to the DNA photolyase family
HM990_RS09030	COG0302	gtp cyclohydrolase
HM990_RS09040	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS09045	COG0386	Belongs to the glutathione peroxidase family
HM990_RS09065	COG0415	Belongs to the DNA photolyase family
HM990_RS09075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HM990_RS09095	COG0514	ATP-dependent DNA helicase (RecQ)
HM990_RS09100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM990_RS09110	COG1678	Uncharacterized ACR, COG1678
HM990_RS09115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HM990_RS09145	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HM990_RS09170	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HM990_RS09195	COG1525	nuclease
HM990_RS09250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HM990_RS09255	COG1702	phosphate starvation-inducible protein PhoH
HM990_RS09295	COG0592	DNA-directed DNA polymerase activity
HM990_RS09310	COG2920	part of a sulfur-relay system
HM990_RS09380	COG3273	potassium ion transport
HM990_RS09380	COG0471	metal ion transport
HM990_RS09385	COG0668	transmembrane transport
HM990_RS09425	COG0701	Predicted permease
HM990_RS09445	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HM990_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS09475	COG0322	excinuclease ABC activity
HM990_RS09495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM990_RS09500	COG2169	Transcriptional regulator
HM990_RS09500	COG1917	Cupin 2, conserved barrel domain protein
HM990_RS09550	COG0604	alcohol dehydrogenase
HM990_RS09555	COG0402	S-adenosylhomocysteine deaminase activity
HM990_RS09555	COG0402	S-adenosylhomocysteine deaminase activity
HM990_RS09565	COG2267	carboxylic ester hydrolase activity
HM990_RS09590	COG0180	Tryptophanyl-tRNA synthetase
HM990_RS09605	COG3275	phosphorelay sensor kinase activity
HM990_RS09645	COG3279	Response regulator of the LytR AlgR family
HM990_RS09655	COG1131	(ABC) transporter
HM990_RS09670	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HM990_RS09675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM990_RS09685	COG1560	Kdo2-lipid A biosynthetic process
HM990_RS09695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HM990_RS09725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HM990_RS09725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HM990_RS09750	COG1846	Transcriptional regulator
HM990_RS09755	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM990_RS09755	COG1024	Enoyl-CoA hydratase
HM990_RS09765	COG0183	Belongs to the thiolase family
HM990_RS09770	COG1960	acyl-CoA dehydrogenase activity
HM990_RS09780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HM990_RS09800	COG0714	Associated with various cellular activities
HM990_RS09815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HM990_RS09845	COG0308	aminopeptidase N
HM990_RS09850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HM990_RS09855	COG0693	protein deglycase activity
HM990_RS09875	COG0517	IMP dehydrogenase activity
HM990_RS09875	COG0516	GMP reductase activity
HM990_RS09910	COG0167	dihydroorotate dehydrogenase activity
HM990_RS09915	COG0589	response to stress
HM990_RS09920	COG2195	Cleaves the N-terminal amino acid of tripeptides
HM990_RS09940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HM990_RS09955	COG0071	Belongs to the small heat shock protein (HSP20) family
HM990_RS09960	COG0022	dehydrogenase e1 component
HM990_RS09980	COG0813	purine-nucleoside phosphorylase activity
HM990_RS09990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HM990_RS09995	COG1288	antiporter activity
HM990_RS10005	COG3011	Protein conserved in bacteria
HM990_RS10010	COG1862	Preprotein translocase
HM990_RS10020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HM990_RS10025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM990_RS10030	COG1132	(ABC) transporter
HM990_RS10040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM990_RS10060	COG1272	protein, Hemolysin III
HM990_RS10070	COG1363	Peptidase, m42
HM990_RS10075	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HM990_RS10080	COG2339	peptidase activity
HM990_RS10090	COG0439	Biotin carboxylase
HM990_RS10095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HM990_RS10100	COG1132	(ABC) transporter
HM990_RS10110	COG2814	Major facilitator Superfamily
HM990_RS10115	COG0009	L-threonylcarbamoyladenylate synthase
HM990_RS10150	COG0438	transferase activity, transferring glycosyl groups
HM990_RS10155	COG1472	Belongs to the glycosyl hydrolase 3 family
HM990_RS10160	COG0560	Phosphoserine phosphatase
HM990_RS10160	COG3830	Belongs to the UPF0237 family
HM990_RS10180	COG0247	lactate metabolic process
HM990_RS10180	COG2181	nitrate reductase activity
HM990_RS10185	COG0247	lactate metabolic process
HM990_RS10185	COG2181	nitrate reductase activity
HM990_RS10190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HM990_RS10195	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM990_RS10205	COG0251	oxidation-reduction process
HM990_RS10225	COG2801	Transposase and inactivated derivatives
HM990_RS10250	COG4251	negative regulation of phosphorylation
HM990_RS10260	COG1215	transferase activity, transferring glycosyl groups
HM990_RS10270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM990_RS10310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HM990_RS10315	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HM990_RS10325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HM990_RS10380	COG0156	8-amino-7-oxononanoate synthase activity
HM990_RS10395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HM990_RS10405	COG1216	Glycosyl transferase, family 2
HM990_RS10425	COG1393	Belongs to the ArsC family
HM990_RS10445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HM990_RS10455	COG1064	alcohol dehydrogenase
HM990_RS10470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HM990_RS10480	COG1012	belongs to the aldehyde dehydrogenase family
HM990_RS10505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM990_RS10515	COG1115	amino acid carrier protein
HM990_RS10520	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS10550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HM990_RS10570	COG0564	pseudouridine synthase activity
HM990_RS10595	COG1120	ATPase activity
HM990_RS10600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HM990_RS10610	COG4206	TonB-dependent receptor
HM990_RS10630	COG4640	response to antibiotic
HM990_RS10685	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HM990_RS10690	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HM990_RS10700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HM990_RS10725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM990_RS10730	COG4166	transmembrane transport
HM990_RS10765	COG0254	rRNA binding
HM990_RS10780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HM990_RS10785	COG1132	(ABC) transporter
HM990_RS10815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HM990_RS10835	COG1611	Belongs to the LOG family
HM990_RS10860	COG0116	Belongs to the methyltransferase superfamily
HM990_RS10860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HM990_RS10865	COG2226	methyltransferase
HM990_RS10915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM990_RS10925	COG0514	ATP-dependent DNA helicase (RecQ)
HM990_RS10935	COG0805	protein transport
HM990_RS10940	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HM990_RS10945	COG1137	ATPase activity
HM990_RS10950	COG2354	Protein conserved in bacteria
HM990_RS10955	COG1183	phosphatidylcholine synthase activity
HM990_RS10970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM990_RS11035	COG0463	Glycosyl transferase, family 2
HM990_RS11045	COG0438	transferase activity, transferring glycosyl groups
HM990_RS11050	COG0438	transferase activity, transferring glycosyl groups
HM990_RS11055	COG2226	methyltransferase
HM990_RS11080	COG1216	Glycosyl transferase, family 2
HM990_RS11085	COG0463	Glycosyl transferase, family 2
HM990_RS11115	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HM990_RS11120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM990_RS11125	COG3206	protein involved in exopolysaccharide biosynthesis
HM990_RS11125	COG0489	protein tyrosine kinase activity
HM990_RS11135	COG0488	(ABC) transporter
HM990_RS11145	COG1136	(ABC) transporter
HM990_RS11165	COG0653	protein targeting
HM990_RS11175	COG2827	Endonuclease containing a URI domain
HM990_RS11230	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HM990_RS11285	COG3275	phosphorelay sensor kinase activity
HM990_RS11310	COG0471	metal ion transport
HM990_RS11345	COG0124	histidyl-tRNA synthetase
HM990_RS11350	COG0577	efflux transmembrane transporter activity
HM990_RS11350	COG1136	(ABC) transporter
HM990_RS11360	COG0584	glycerophosphoryl diester phosphodiesterase
HM990_RS11365	COG0359	binds to the 23S rRNA
HM990_RS11370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HM990_RS11375	COG0360	Binds together with S18 to 16S ribosomal RNA
HM990_RS11380	COG3279	Response regulator of the LytR AlgR family
HM990_RS11385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HM990_RS11420	COG3275	phosphorelay sensor kinase activity
HM990_RS11425	COG3279	Response regulator of the LytR AlgR family
HM990_RS11430	COG1295	ribonuclease BN
HM990_RS11440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HM990_RS11455	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HM990_RS11480	COG1454	alcohol dehydrogenase
HM990_RS11495	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HM990_RS11505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM990_RS11520	COG0742	ribosomal rna small subunit methyltransferase
HM990_RS11580	COG3384	dioxygenase
HM990_RS11660	COG0714	Associated with various cellular activities
HM990_RS11685	COG1595	DNA-templated transcription, initiation
HM990_RS11695	COG0783	Belongs to the Dps family
HM990_RS11755	COG0492	ferredoxin-NADP+ reductase activity
HM990_RS11810	COG1012	belongs to the aldehyde dehydrogenase family
HM990_RS11825	COG2133	pyrroloquinoline quinone binding
HM990_RS11830	COG2010	Cytochrome c
HM990_RS11835	COG0572	uridine kinase
HM990_RS11845	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM990_RS11855	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM990_RS11855	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM990_RS11860	COG1506	peptidase
HM990_RS11860	COG0823	Involved in the tonB-independent uptake of proteins
HM990_RS11860	COG4946	Tricorn protease homolog
HM990_RS11865	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS11870	COG1192	Involved in chromosome partitioning
HM990_RS11875	COG1475	DNA binding
HM990_RS11885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HM990_RS11890	COG0681	Belongs to the peptidase S26 family
HM990_RS11920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HM990_RS11930	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HM990_RS11940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HM990_RS11985	COG0105	UTP biosynthetic process
HM990_RS11990	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HM990_RS12000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM990_RS12005	COG2195	Cleaves the N-terminal amino acid of tripeptides
HM990_RS12030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HM990_RS12030	COG5549	protein import
HM990_RS12035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM990_RS12040	COG0501	Belongs to the peptidase M48B family
HM990_RS12060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HM990_RS12070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HM990_RS12080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM990_RS12100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HM990_RS12120	COG3956	TIGRFAM MazG family protein
HM990_RS12130	COG0242	peptide deformylase activity
HM990_RS12135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HM990_RS12140	COG2171	N-acyltransferase activity
HM990_RS12165	COG0463	Glycosyl transferase, family 2
HM990_RS12170	COG0463	Glycosyl transferase, family 2
HM990_RS12175	COG0726	polysaccharide deacetylase
HM990_RS12185	COG0463	Glycosyl transferase, family 2
HM990_RS12205	COG0367	asparagine synthase
HM990_RS12230	COG0617	tRNA 3'-terminal CCA addition
HM990_RS12235	COG1612	heme a metabolic process
HM990_RS12255	COG1131	(ABC) transporter
HM990_RS12295	COG0556	nucleotide-excision repair
HM990_RS12315	COG0045	succinate-CoA ligase (ADP-forming) activity
HM990_RS12325	COG0019	diaminopimelate decarboxylase activity
HM990_RS12385	COG2326	polyphosphate kinase activity
HM990_RS12400	COG3264	Mechanosensitive ion channel
HM990_RS12400	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HM990_RS12405	COG1668	transmembrane transport
HM990_RS12410	COG4152	abc transporter atp-binding protein
HM990_RS12415	COG0484	heat shock protein binding
HM990_RS12420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HM990_RS12435	COG2197	response regulator
HM990_RS12440	COG4585	Histidine kinase
HM990_RS12450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HM990_RS12465	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HM990_RS12465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HM990_RS12470	COG1090	epimerase
HM990_RS12520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HM990_RS12575	COG2949	membrane
HM990_RS12600	COG0300	oxidoreductase activity
HM990_RS12625	COG1482	cell wall glycoprotein biosynthetic process
HM990_RS12655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM990_RS12665	COG2204	response regulator
HM990_RS12675	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HM990_RS12750	COG0800	Aldolase
HM990_RS12755	COG0205	6-phosphofructokinase activity
HM990_RS12775	COG2271	Major facilitator Superfamily
HM990_RS12780	COG2186	Transcriptional regulator
HM990_RS12800	COG0702	epimerase
HM990_RS12805	COG4771	TonB-dependent receptor
HM990_RS12820	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS12830	COG1914	H( )-stimulated, divalent metal cation uptake system
HM990_RS12855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HM990_RS12860	COG0085	RNA polymerase activity
HM990_RS12865	COG0222	ribosome binding
HM990_RS12870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HM990_RS12875	COG0081	regulation of translation
HM990_RS12880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HM990_RS12900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HM990_RS12925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HM990_RS12930	COG4974	Belongs to the 'phage' integrase family
HM990_RS12935	COG0366	Alpha amylase catalytic
HM990_RS12950	COG1115	amino acid carrier protein
HM990_RS12955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HM990_RS12980	COG3665	Urea carboxylase-associated protein
HM990_RS12990	COG2323	membrane
HM990_RS13015	COG4251	negative regulation of phosphorylation
HM990_RS13030	COG0577	efflux transmembrane transporter activity
HM990_RS13035	COG3876	Protein conserved in bacteria
HM990_RS13045	COG0584	glycerophosphoryl diester phosphodiesterase
HM990_RS13070	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HM990_RS13095	COG0159	tryptophan synthase activity
HM990_RS13125	COG4628	conserved protein (DUF2132)
HM990_RS13135	COG0513	Belongs to the DEAD box helicase family
HM990_RS13150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM990_RS13155	COG3275	phosphorelay sensor kinase activity
HM990_RS13160	COG3279	Response regulator of the LytR AlgR family
HM990_RS13180	COG3022	response to hydroperoxide
HM990_RS13200	COG0564	pseudouridine synthase activity
HM990_RS13210	COG1181	Belongs to the D-alanine--D-alanine ligase family
HM990_RS13215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HM990_RS13245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HM990_RS13285	COG1160	GTP binding
HM990_RS13290	COG0791	NLP P60 protein
HM990_RS13290	COG1388	LysM domain
HM990_RS13315	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HM990_RS13320	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HM990_RS13325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM990_RS13345	COG4946	Tricorn protease homolog
HM990_RS13345	COG0793	Belongs to the peptidase S41A family
HM990_RS13365	COG1764	response to oxidative stress
HM990_RS13370	COG4206	TonB-dependent receptor
HM990_RS13390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HM990_RS13395	COG1960	acyl-CoA dehydrogenase activity
HM990_RS13405	COG2423	ornithine cyclodeaminase activity
HM990_RS13425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HM990_RS13450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM990_RS13495	COG0409	Hydrogenase expression formation protein
HM990_RS13500	COG0298	carbon dioxide binding
HM990_RS13505	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HM990_RS13510	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HM990_RS13580	COG4942	peptidase
HM990_RS13800	COG0443	Heat shock 70 kDa protein
HM990_RS14000	COG1609	Transcriptional regulator
HM990_RS14005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HM990_RS14015	COG1085	galactose-1-phosphate uridylyltransferase
HM990_RS14020	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HM990_RS14025	COG2271	Major facilitator Superfamily
HM990_RS14030	COG0584	glycerophosphoryl diester phosphodiesterase
HM990_RS14055	COG0702	epimerase
HM990_RS14060	COG4771	TonB-dependent receptor
HM990_RS14095	COG0730	response to heat
HM990_RS14100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HM990_RS14120	COG2264	protein methyltransferase activity
HM990_RS14155	COG0149	triose-phosphate isomerase activity
HM990_RS14175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HM990_RS14195	COG1132	(ABC) transporter
HM990_RS14200	COG0101	tRNA pseudouridine synthase activity
HM990_RS14250	COG1629	transport
HM990_RS14250	COG4206	TonB-dependent receptor
HM990_RS14255	COG1621	beta-fructofuranosidase activity
HM990_RS14260	COG2814	Major facilitator Superfamily
HM990_RS14265	COG0745	RESPONSE REGULATOR receiver
HM990_RS14265	COG3292	Two component regulator propeller
HM990_RS14265	COG2205	protein histidine kinase activity
HM990_RS14275	COG4974	Belongs to the 'phage' integrase family
HM990_RS14405	COG0656	L-ascorbic acid biosynthetic process
HM990_RS14435	COG2801	Transposase and inactivated derivatives
HM990_RS14480	COG0656	L-ascorbic acid biosynthetic process
HM990_RS14505	COG3547	Transposase (IS116 IS110 IS902 family)
HM990_RS14575	COG0488	(ABC) transporter
HM990_RS14585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HM990_RS14605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM990_RS14630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM990_RS14635	COG3604	Transcriptional regulator
HM990_RS14660	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HM990_RS14665	COG0459	protein refolding
HM990_RS14720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HM990_RS14725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HM990_RS14730	COG0563	adenylate kinase activity
HM990_RS14735	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HM990_RS14745	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HM990_RS14750	COG0339	signal peptide processing
HM990_RS14795	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HM990_RS14795	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HM990_RS14800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM990_RS14810	COG1215	transferase activity, transferring glycosyl groups
HM990_RS14825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HM990_RS14830	COG1127	ABC transporter
HM990_RS14855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HM990_RS14860	COG0484	heat shock protein binding
HM990_RS14870	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS14880	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM990_RS14885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HM990_RS14890	COG0295	cytidine deaminase activity
HM990_RS14905	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM990_RS14910	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HM990_RS14915	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HM990_RS14940	COG0285	dihydrofolate synthase activity
HM990_RS14950	COG0848	biopolymer transport protein
HM990_RS14955	COG0811	peptide transport
HM990_RS14960	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HM990_RS14970	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HM990_RS14975	COG1960	acyl-CoA dehydrogenase activity
HM990_RS14980	COG0745	RESPONSE REGULATOR receiver
HM990_RS14980	COG2205	protein histidine kinase activity
HM990_RS14980	COG3292	Two component regulator propeller
HM990_RS14985	COG3292	Two component regulator propeller
HM990_RS14985	COG2205	protein histidine kinase activity
HM990_RS14985	COG0745	RESPONSE REGULATOR receiver
HM990_RS15020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM990_RS15070	COG4771	TonB-dependent receptor
HM990_RS15075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HM990_RS15100	COG0321	lipoyl(octanoyl) transferase activity
HM990_RS15110	COG0401	homolog of Blt101
HM990_RS15115	COG2197	response regulator
HM990_RS15125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HM990_RS15165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HM990_RS15175	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HM990_RS15195	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HM990_RS15205	COG0659	secondary active sulfate transmembrane transporter activity
HM990_RS15210	COG1278	Cold shock
HM990_RS15215	COG2076	Multidrug Resistance protein
HM990_RS15220	COG0358	DNA primase activity
HM990_RS15225	COG2197	response regulator
HM990_RS15230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HM990_RS15280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HM990_RS15285	COG3396	Phenylacetate-CoA oxygenase
HM990_RS15290	COG3460	Phenylacetate-CoA oxygenase
HM990_RS15295	COG3396	Phenylacetate-CoA oxygenase
HM990_RS15300	COG2151	metal-sulfur cluster biosynthetic enzyme
HM990_RS15305	COG1024	Enoyl-CoA hydratase
HM990_RS15315	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM990_RS15330	COG2321	neutral zinc metallopeptidase
HM990_RS15335	COG0183	Belongs to the thiolase family
HM990_RS15340	COG2030	dehydratase
HM990_RS15340	COG1012	belongs to the aldehyde dehydrogenase family
HM990_RS15370	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM990_RS15375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HM990_RS15380	COG0022	dehydrogenase e1 component
HM990_RS15410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HM990_RS15415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HM990_RS15420	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HM990_RS15440	COG1988	membrane-bound metal-dependent
HM990_RS15445	COG1490	D-aminoacyl-tRNA deacylase activity
HM990_RS15450	COG1162	GTPase activity
HM990_RS15465	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HM990_RS15470	COG0287	Prephenate dehydrogenase
HM990_RS15475	COG0436	Aminotransferase
HM990_RS15480	COG0077	Prephenate dehydratase
HM990_RS15480	COG1605	Chorismate mutase
HM990_RS15485	COG1131	(ABC) transporter
HM990_RS15490	COG0857	belongs to the CobB CobQ family
HM990_RS15490	COG0280	phosphate acetyltransferase
HM990_RS15495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HM990_RS15515	COG1045	serine acetyltransferase
HM990_RS15520	COG0492	ferredoxin-NADP+ reductase activity
HM990_RS15530	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HM990_RS15545	COG1959	2 iron, 2 sulfur cluster binding
HM990_RS15560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HM990_RS15565	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HM990_RS15575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HM990_RS15585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HM990_RS15595	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HM990_RS15600	COG2086	electron transfer activity
HM990_RS15605	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM990_RS15605	COG0022	dehydrogenase e1 component
HM990_RS15620	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HM990_RS15635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HM990_RS15640	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HM990_RS15645	COG0357	Ribosomal RNA small subunit methyltransferase G
HM990_RS15650	COG3239	Fatty acid desaturase
HM990_RS15655	COG0436	Aminotransferase
HM990_RS15680	COG0569	domain protein
HM990_RS15685	COG2226	methyltransferase
HM990_RS15695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM990_RS15705	COG0191	fructose-bisphosphate aldolase activity
HM990_RS15710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HM990_RS15720	COG2205	protein histidine kinase activity
HM990_RS15725	COG3290	protein histidine kinase activity
HM990_RS15730	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HM990_RS15735	COG1185	polyribonucleotide nucleotidyltransferase activity
HM990_RS15765	COG1215	transferase activity, transferring glycosyl groups
HM990_RS15770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HM990_RS15775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HM990_RS15780	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HM990_RS15790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HM990_RS15795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HM990_RS15815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM990_RS15820	COG1216	Glycosyl transferase, family 2
HM990_RS15825	COG0110	maltose O-acetyltransferase activity
HM990_RS15830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM990_RS15830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM990_RS15865	COG1216	Glycosyl transferase, family 2
HM990_RS15870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HM990_RS15875	COG1215	transferase activity, transferring glycosyl groups
HM990_RS15880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HM990_RS15895	COG1215	transferase activity, transferring glycosyl groups
HM990_RS15925	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HM990_RS15940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM990_RS15945	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HM990_RS15965	COG0529	Catalyzes the synthesis of activated sulfate
HM990_RS16020	COG0069	glutamate synthase activity
HM990_RS16025	COG1289	transmembrane transporter activity
HM990_RS16055	COG1610	YqeY-like protein
HM990_RS16060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HM990_RS16075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HM990_RS16080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HM990_RS16085	COG0772	Belongs to the SEDS family
HM990_RS16090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HM990_RS16095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM990_RS16100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HM990_RS16115	COG0275	rRNA processing
HM990_RS16120	COG2001	Belongs to the MraZ family
HM990_RS16125	COG2267	carboxylic ester hydrolase activity
HM990_RS16130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HM990_RS16135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HM990_RS16140	COG0793	Belongs to the peptidase S41A family
HM990_RS16145	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HM990_RS16150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM990_RS16155	COG0791	NLP P60 protein
HM990_RS16160	COG0658	competence protein
HM990_RS16160	COG2333	competence protein COMEC
HM990_RS16170	COG3104	oligopeptide transport
HM990_RS16175	COG3104	oligopeptide transport
HM990_RS16230	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HM990_RS16240	COG2217	Heavy metal translocating P-type atpase
HM990_RS16295	COG2217	Heavy metal translocating P-type atpase
HM990_RS16300	COG2132	Multicopper oxidase
HM990_RS16315	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HM990_RS16375	COG2814	Major facilitator Superfamily
HM990_RS16375	COG0477	Major facilitator Superfamily
HM990_RS16390	COG3119	arylsulfatase activity
HM990_RS16400	COG3250	beta-galactosidase activity
HM990_RS16440	COG0702	epimerase
HM990_RS16445	COG4771	TonB-dependent receptor
HM990_RS16455	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM990_RS16465	COG0129	dihydroxy-acid dehydratase activity
HM990_RS16470	COG0028	Belongs to the TPP enzyme family
HM990_RS16480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HM990_RS16485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HM990_RS16490	COG1012	belongs to the aldehyde dehydrogenase family
HM990_RS16500	COG0137	argininosuccinate synthase activity
HM990_RS16505	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HM990_RS16515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM990_RS16525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HM990_RS16535	COG0165	Argininosuccinate lyase
HM990_RS16540	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HM990_RS16545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HM990_RS16550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HM990_RS16560	COG0131	Imidazoleglycerol-phosphate dehydratase
HM990_RS16570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HM990_RS16575	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HM990_RS16580	COG0107	imidazoleglycerol-phosphate synthase activity
HM990_RS16585	COG0140	phosphoribosyl-ATP diphosphatase activity
HM990_RS16585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HM990_RS16595	COG0069	glutamate synthase activity
HM990_RS16595	COG0067	glutamate synthase
HM990_RS16595	COG0070	glutamate synthase
HM990_RS16605	COG0004	ammonium transporteR
HM990_RS16610	COG0347	Belongs to the P(II) protein family
HM990_RS16615	COG0004	ammonium transporteR
HM990_RS16620	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HM990_RS16630	COG0066	3-isopropylmalate dehydratase activity
HM990_RS16635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HM990_RS16640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HM990_RS16655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HM990_RS16670	COG0590	tRNA wobble adenosine to inosine editing
HM990_RS16680	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HM990_RS16690	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HM990_RS16690	COG3608	succinylglutamate desuccinylase aspartoacylase
HM990_RS16715	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HM990_RS16720	COG2226	methyltransferase
HM990_RS16755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HM990_RS16770	COG1215	transferase activity, transferring glycosyl groups
HM990_RS16795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HM990_RS16795	COG3153	acetyltransferase
HM990_RS16800	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HM990_RS16805	COG0010	Belongs to the arginase family
HM990_RS16810	COG1166	arginine decarboxylase activity
HM990_RS16815	COG3279	Response regulator of the LytR AlgR family
HM990_RS16835	COG3547	Transposase (IS116 IS110 IS902 family)
HM990_RS16845	COG1187	pseudouridine synthase activity
HM990_RS16890	COG0784	Response regulator, receiver
HM990_RS16890	COG2205	protein histidine kinase activity
HM990_RS16895	COG2081	HI0933 family
HM990_RS16915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM990_RS16935	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HM990_RS16955	COG1082	Xylose isomerase domain protein TIM barrel
HM990_RS16960	COG0366	Alpha amylase catalytic
HM990_RS16970	COG1523	belongs to the glycosyl hydrolase 13 family
HM990_RS16975	COG1501	Belongs to the glycosyl hydrolase 31 family
HM990_RS16985	COG0366	Alpha amylase catalytic
HM990_RS16990	COG1554	hydrolase, family 65, central catalytic
HM990_RS16995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HM990_RS17010	COG1629	transport
HM990_RS17010	COG4206	TonB-dependent receptor
HM990_RS17015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HM990_RS17035	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HM990_RS17040	COG0228	four-way junction DNA binding
HM990_RS17045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HM990_RS17050	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HM990_RS17055	COG0628	permease
HM990_RS17090	COG0463	Glycosyl transferase, family 2
HM990_RS17095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM990_RS17105	COG1090	epimerase
HM990_RS17110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HM990_RS17135	COG0745	RESPONSE REGULATOR receiver
HM990_RS17140	COG5002	protein histidine kinase activity
HM990_RS17145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HM990_RS17150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HM990_RS17170	COG0489	protein tyrosine kinase activity
HM990_RS17175	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HM990_RS17180	COG0492	ferredoxin-NADP+ reductase activity
HM990_RS17185	COG0633	Ferredoxin
HM990_RS17190	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HM990_RS17195	COG2363	Small membrane protein
HM990_RS17205	COG1522	sequence-specific DNA binding
HM990_RS17215	COG0667	Aldo Keto reductase
HM990_RS17220	COG1360	Flagellar Motor Protein
HM990_RS17225	COG0708	Exodeoxyribonuclease III
HM990_RS17240	COG0423	glycine-tRNA ligase activity
HM990_RS17250	COG1040	competence protein
HM990_RS17260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HM990_RS17270	COG0436	Aminotransferase
HM990_RS17275	COG4717	serine-type aminopeptidase activity
HM990_RS17305	COG0495	leucyl-tRNA aminoacylation
HM990_RS17310	COG2177	Part of the ABC transporter FtsEX involved in
HM990_RS17320	COG1968	undecaprenyl-diphosphatase activity
HM990_RS17325	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HM990_RS17340	COG0519	Catalyzes the synthesis of GMP from XMP
HM990_RS17345	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HM990_RS17355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HM990_RS17360	COG3852	Histidine kinase
HM990_RS17365	COG2827	Endonuclease containing a URI domain
HM990_RS17380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM990_RS17420	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HM990_RS17430	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HM990_RS17440	COG1530	ribonuclease E activity
HM990_RS17445	COG0776	regulation of translation
HM990_RS17450	COG1194	a g-specific adenine glycosylase
HM990_RS17475	COG4206	TonB-dependent receptor
HM990_RS17475	COG1629	transport
HM990_RS17480	COG0166	Belongs to the GPI family
HM990_RS17490	COG3483	tryptophan 2,3-dioxygenase activity
HM990_RS17500	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HM990_RS17510	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HM990_RS17535	COG4771	TonB-dependent receptor
HM990_RS17540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HM990_RS17550	COG0297	glycogen (starch) synthase activity
HM990_RS17555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HM990_RS17560	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HM990_RS17580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HM990_RS17590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HM990_RS17610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HM990_RS17615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HM990_RS17625	COG0189	ligase activity
HM990_RS17630	COG4067	protein conserved in archaea
HM990_RS17630	COG0189	ligase activity
HM990_RS17635	COG0322	excinuclease ABC activity
HM990_RS17640	COG1752	Esterase of the alpha-beta hydrolase superfamily
HM990_RS17665	COG0587	DNA-directed DNA polymerase activity
HM990_RS17670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HM990_RS17690	COG2268	Band 7 protein
HM990_RS17725	COG1381	Involved in DNA repair and RecF pathway recombination
HM990_RS17735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM990_RS17745	COG0626	cystathionine gamma-synthase activity
HM990_RS17770	COG0697	spore germination
HM990_RS17785	COG1561	YicC-like family, N-terminal region
HM990_RS17790	COG0194	GDP metabolic process
HM990_RS17795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HM990_RS17800	COG0792	nuclease activity
HM990_RS17815	COG1619	proteins homologs of microcin C7 resistance protein MccF
HM990_RS17820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM990_RS17820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM990_RS17835	COG2183	response to ionizing radiation
HM990_RS17840	COG0123	including yeast histone deacetylase and acetoin utilization protein
HM990_RS17850	COG3712	iron ion homeostasis
HM990_RS17895	COG1528	Iron-storage protein
HM990_RS17950	COG3547	Transposase (IS116 IS110 IS902 family)
HM990_RS17960	COG0629	single-stranded DNA binding
HM990_RS17965	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS17970	COG0596	Alpha beta hydrolase
HM990_RS17975	COG4771	TonB-dependent receptor
HM990_RS18005	COG0516	GMP reductase activity
HM990_RS18005	COG0517	IMP dehydrogenase activity
HM990_RS18025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM990_RS18080	COG0750	zinc metalloprotease
HM990_RS18090	COG1999	signal sequence binding
HM990_RS18115	COG4771	TonB-dependent receptor
HM990_RS18120	COG0803	Belongs to the bacterial solute-binding protein 9 family
HM990_RS18125	COG1121	(ABC) transporter
HM990_RS18130	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HM990_RS18135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HM990_RS18150	COG1629	transport
HM990_RS18165	COG1858	cytochrome C peroxidase
HM990_RS18190	COG1418	mRNA catabolic process
HM990_RS18200	COG2207	Transcriptional regulator
HM990_RS18225	COG3177	Filamentation induced by cAMP protein fic
HM990_RS18235	COG1024	Enoyl-CoA hydratase
HM990_RS18240	COG5000	phosphorelay sensor kinase activity
HM990_RS18255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HM990_RS18270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HM990_RS18275	COG0181	hydroxymethylbilane synthase activity
HM990_RS18285	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HM990_RS18300	COG0408	coproporphyrinogen oxidase activity
HM990_RS18305	COG0113	porphobilinogen synthase activity
HM990_RS18310	COG1253	flavin adenine dinucleotide binding
HM990_RS18315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HM990_RS18350	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HM990_RS18355	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HM990_RS18365	COG1774	PSP1 C-terminal conserved region
HM990_RS18370	COG0739	heme binding
HM990_RS18370	COG0741	lytic transglycosylase activity
HM990_RS18370	COG1196	nuclear chromosome segregation
HM990_RS18380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HM990_RS18420	COG1607	acyl-coa hydrolase
HM990_RS18445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HM990_RS18450	COG0756	dUTP diphosphatase activity
HM990_RS18475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HM990_RS18480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HM990_RS18485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HM990_RS18490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HM990_RS18495	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HM990_RS18500	COG0356	it plays a direct role in the translocation of protons across the membrane
HM990_RS18535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HM990_RS18550	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HM990_RS18565	COG0151	Belongs to the GarS family
HM990_RS18585	COG0297	glycogen (starch) synthase activity
HM990_RS18590	COG0110	maltose O-acetyltransferase activity
HM990_RS18615	COG2244	polysaccharide biosynthetic process
HM990_RS18650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HM990_RS18660	COG0791	NLP P60 protein
HM990_RS18660	COG1388	LysM domain
HM990_RS18665	COG0126	phosphoglycerate kinase activity
HM990_RS18670	COG0470	DNA polymerase III
HM990_RS18690	COG0445	tRNA wobble uridine modification
HM990_RS18695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HM990_RS18705	COG3239	Fatty acid desaturase
HM990_RS18710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HM990_RS18730	COG2801	Transposase and inactivated derivatives
HM990_RS18735	COG2801	Transposase and inactivated derivatives
HM990_RS18755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HM990_RS18790	COG0393	Putative heavy-metal-binding
HM990_RS18795	COG0557	exoribonuclease II activity
HM990_RS18805	COG0698	ribose 5-phosphate isomerase
HM990_RS18815	COG2153	protein acetylation
HM990_RS18825	COG0793	Belongs to the peptidase S41A family
HM990_RS18830	COG0594	ribonuclease P activity
HM990_RS18850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HM990_RS18860	COG3263	regulation of cellular component size
HM990_RS18875	COG2197	response regulator
HM990_RS18880	COG0481	GTPase activity
HM990_RS18895	COG2234	aminopeptidase activity
HM990_RS18925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HM990_RS18930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HM990_RS18935	COG4591	ABC-type transport system involved in lipoprotein release permease component
HM990_RS18940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HM990_RS18945	COG0346	lactoylglutathione lyase activity
HM990_RS18960	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS18965	COG1312	Catalyzes the dehydration of D-mannonate
HM990_RS18970	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HM990_RS18975	COG1028	Short-chain dehydrogenase reductase Sdr
HM990_RS18990	COG2249	NAD(P)H dehydrogenase (quinone) activity
HM990_RS18995	COG1538	Outer membrane efflux protein
HM990_RS19005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM990_RS19030	COG1566	PFAM secretion protein HlyD family protein
HM990_RS19035	COG1538	Outer membrane efflux protein
HM990_RS19045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM990_RS19050	COG1086	Polysaccharide biosynthesis protein
HM990_RS19055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM990_RS19065	COG0667	Aldo Keto reductase
HM990_RS19085	COG2089	acid synthase
HM990_RS19105	COG1216	Glycosyl transferase, family 2
HM990_RS19125	COG1215	transferase activity, transferring glycosyl groups
HM990_RS19135	COG3206	protein involved in exopolysaccharide biosynthesis
HM990_RS19135	COG0489	protein tyrosine kinase activity
HM990_RS19155	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HM990_RS19165	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HM990_RS19170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM990_RS19175	COG0511	ligase activity, forming carbon-carbon bonds
HM990_RS19180	COG0439	Biotin carboxylase
HM990_RS19195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HM990_RS19205	COG2353	YceI-like domain
HM990_RS19220	COG3424	synthase
HM990_RS19225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM990_RS19235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM990_RS19250	COG3842	ATPase activity
HM990_RS19260	COG1505	serine-type exopeptidase activity
HM990_RS19265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HM990_RS19270	COG1970	mechanosensitive ion channel activity
HM990_RS19275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HM990_RS19280	COG1435	thymidine kinase activity
HM990_RS19290	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HM990_RS19300	COG1573	uracil-dna glycosylase
HM990_RS19330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HM990_RS19330	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HM990_RS19345	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM990_RS19350	COG0720	synthase
HM990_RS19385	COG2205	protein histidine kinase activity
HM990_RS19385	COG0784	Response regulator, receiver
HM990_RS19400	COG0784	Response regulator, receiver
HM990_RS19400	COG2205	protein histidine kinase activity
HM990_RS19425	COG1074	ATP-dependent DNA helicase activity
HM990_RS19440	COG0352	thiamine-phosphate diphosphorylase activity
HM990_RS19440	COG0351	phosphomethylpyrimidine kinase
HM990_RS19460	COG0328	RNA-DNA hybrid ribonuclease activity
HM990_RS19460	COG3341	Caulimovirus viroplasmin
HM990_RS19470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM990_RS19475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM990_RS19480	COG0571	ribonuclease III activity
HM990_RS19490	COG0469	pyruvate kinase activity
HM990_RS19495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HM990_RS19500	COG2954	triphosphatase activity
HM990_RS19520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HM990_RS19545	COG2151	metal-sulfur cluster biosynthetic enzyme
HM990_RS19550	COG2166	iron-sulfur cluster assembly
HM990_RS19560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HM990_RS19585	COG0719	Fe-S assembly protein
HM990_RS19590	COG0396	ATPase activity
HM990_RS19600	COG0719	Fe-S assembly protein
HM990_RS19610	COG0316	Belongs to the HesB IscA family
HM990_RS19620	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HM990_RS19645	COG0527	aspartate kinase activity
HM990_RS19665	COG0006	proline dipeptidase activity
HM990_RS19670	COG4447	cellulose binding
HM990_RS19685	COG1053	succinate dehydrogenase
HM990_RS19695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HM990_RS19705	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HM990_RS19710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HM990_RS19715	COG0612	Peptidase, M16
HM990_RS19720	COG0612	Peptidase, M16
HM990_RS19765	COG4953	penicillin-binding protein 1C