locus-tag	class	description
HM991_RS00045	COG0745	RESPONSE REGULATOR receiver
HM991_RS00055	COG1482	cell wall glycoprotein biosynthetic process
HM991_RS00060	COG2824	Alkylphosphonate utilization operon protein PhnA
HM991_RS00115	COG2814	Major facilitator Superfamily
HM991_RS00140	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HM991_RS00145	COG4206	TonB-dependent receptor
HM991_RS00145	COG1629	transport
HM991_RS00160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HM991_RS00165	COG1554	hydrolase, family 65, central catalytic
HM991_RS00170	COG0366	Alpha amylase catalytic
HM991_RS00175	COG2819	hydrolase of the alpha beta superfamily
HM991_RS00180	COG1501	Belongs to the glycosyl hydrolase 31 family
HM991_RS00190	COG0366	Alpha amylase catalytic
HM991_RS00195	COG1082	Xylose isomerase domain protein TIM barrel
HM991_RS00200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HM991_RS00220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM991_RS00240	COG2081	HI0933 family
HM991_RS00245	COG2198	Histidine kinase
HM991_RS00245	COG0784	Response regulator, receiver
HM991_RS00245	COG5002	protein histidine kinase activity
HM991_RS00270	COG1187	pseudouridine synthase activity
HM991_RS00310	COG3279	Response regulator of the LytR AlgR family
HM991_RS00315	COG2972	Histidine kinase
HM991_RS00325	COG0427	acetyl-CoA hydrolase
HM991_RS00340	COG0010	Belongs to the arginase family
HM991_RS00345	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HM991_RS00350	COG3153	acetyltransferase
HM991_RS00350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HM991_RS00375	COG1215	transferase activity, transferring glycosyl groups
HM991_RS00380	COG0463	Glycosyl transferase, family 2
HM991_RS00390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HM991_RS00435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HM991_RS00465	COG1629	transport
HM991_RS00465	COG4206	TonB-dependent receptor
HM991_RS00485	COG3608	succinylglutamate desuccinylase aspartoacylase
HM991_RS00485	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HM991_RS00515	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HM991_RS00530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM991_RS00535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HM991_RS00550	COG0590	tRNA wobble adenosine to inosine editing
HM991_RS00585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HM991_RS00590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HM991_RS00595	COG0066	3-isopropylmalate dehydratase activity
HM991_RS00610	COG0004	ammonium transporteR
HM991_RS00620	COG0067	glutamate synthase
HM991_RS00620	COG0070	glutamate synthase
HM991_RS00620	COG0069	glutamate synthase activity
HM991_RS00630	COG0165	Argininosuccinate lyase
HM991_RS00640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HM991_RS00645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HM991_RS00650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM991_RS00660	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HM991_RS00675	COG1012	belongs to the aldehyde dehydrogenase family
HM991_RS00680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HM991_RS00685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HM991_RS00695	COG0028	Belongs to the TPP enzyme family
HM991_RS00700	COG0129	dihydroxy-acid dehydratase activity
HM991_RS00705	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM991_RS00715	COG1629	transport
HM991_RS00720	COG0702	epimerase
HM991_RS00750	COG3250	beta-galactosidase activity
HM991_RS00760	COG3119	arylsulfatase activity
HM991_RS00780	COG2814	Major facilitator Superfamily
HM991_RS00780	COG0477	Major facilitator Superfamily
HM991_RS00820	COG1472	Belongs to the glycosyl hydrolase 3 family
HM991_RS00825	COG5520	Belongs to the glycosyl hydrolase 30 family
HM991_RS00825	COG4447	cellulose binding
HM991_RS00825	COG3291	Pkd domain containing protein
HM991_RS00840	COG2942	2-epimerase
HM991_RS00845	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HM991_RS00860	COG2169	Transcriptional regulator
HM991_RS00865	COG4771	TonB-dependent receptor
HM991_RS00870	COG0561	phosphatase activity
HM991_RS00885	COG3292	Two component regulator propeller
HM991_RS00885	COG0745	RESPONSE REGULATOR receiver
HM991_RS00885	COG2205	protein histidine kinase activity
HM991_RS00890	COG4771	TonB-dependent receptor
HM991_RS00905	COG1914	H( )-stimulated, divalent metal cation uptake system
HM991_RS00910	COG1482	cell wall glycoprotein biosynthetic process
HM991_RS00935	COG1028	Short-chain dehydrogenase reductase Sdr
HM991_RS00940	COG1312	Catalyzes the dehydration of D-mannonate
HM991_RS00950	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HM991_RS00980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HM991_RS00995	COG0823	Involved in the tonB-independent uptake of proteins
HM991_RS00995	COG1506	peptidase
HM991_RS01000	COG3104	oligopeptide transport
HM991_RS01005	COG3104	oligopeptide transport
HM991_RS01015	COG0658	competence protein
HM991_RS01015	COG2333	competence protein COMEC
HM991_RS01020	COG0791	NLP P60 protein
HM991_RS01030	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM991_RS01040	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HM991_RS01045	COG0793	Belongs to the peptidase S41A family
HM991_RS01050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HM991_RS01055	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HM991_RS01060	COG2267	carboxylic ester hydrolase activity
HM991_RS01065	COG2001	Belongs to the MraZ family
HM991_RS01070	COG0275	rRNA processing
HM991_RS01080	COG0768	penicillin binding
HM991_RS01085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HM991_RS01090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM991_RS01095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HM991_RS01100	COG0772	Belongs to the SEDS family
HM991_RS01105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HM991_RS01110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HM991_RS01125	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HM991_RS01130	COG1610	YqeY-like protein
HM991_RS01185	COG1289	transmembrane transporter activity
HM991_RS01190	COG0069	glutamate synthase activity
HM991_RS01200	COG1320	monovalent cation:proton antiporter activity
HM991_RS01205	COG2212	antiporter activity
HM991_RS01225	COG2111	Na H antiporter
HM991_RS01235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM991_RS01280	COG0529	Catalyzes the synthesis of activated sulfate
HM991_RS01300	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HM991_RS01305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM991_RS01315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HM991_RS01330	COG1132	(ABC) transporter
HM991_RS01355	COG0463	Glycosyl transferase, family 2
HM991_RS01360	COG1215	transferase activity, transferring glycosyl groups
HM991_RS01390	COG0438	transferase activity, transferring glycosyl groups
HM991_RS01405	COG2171	N-acyltransferase activity
HM991_RS01415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HM991_RS01430	COG0617	tRNA 3'-terminal CCA addition
HM991_RS01430	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HM991_RS01430	COG0517	IMP dehydrogenase activity
HM991_RS01435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HM991_RS01440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HM991_RS01450	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HM991_RS01455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HM991_RS01465	COG1215	transferase activity, transferring glycosyl groups
HM991_RS01475	COG1185	polyribonucleotide nucleotidyltransferase activity
HM991_RS01480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HM991_RS01490	COG5002	protein histidine kinase activity
HM991_RS01490	COG3447	MASE1 domain protein
HM991_RS01490	COG5001	Diguanylate cyclase
HM991_RS01495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HM991_RS01500	COG0191	fructose-bisphosphate aldolase activity
HM991_RS01510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM991_RS01520	COG2226	methyltransferase
HM991_RS01525	COG0569	domain protein
HM991_RS01550	COG0436	Aminotransferase
HM991_RS01555	COG3239	Fatty acid desaturase
HM991_RS01560	COG0357	Ribosomal RNA small subunit methyltransferase G
HM991_RS01585	COG1012	belongs to the aldehyde dehydrogenase family
HM991_RS01590	COG2967	ApaG domain
HM991_RS01605	COG1805	sodium ion transport
HM991_RS01610	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HM991_RS01630	COG0643	Histidine kinase
HM991_RS01630	COG0784	Response regulator, receiver
HM991_RS01630	COG2198	Histidine kinase
HM991_RS01635	COG5002	protein histidine kinase activity
HM991_RS01635	COG5001	Diguanylate cyclase
HM991_RS01635	COG3447	MASE1 domain protein
HM991_RS01650	COG2311	Membrane
HM991_RS01680	COG4585	Histidine kinase
HM991_RS01685	COG2197	response regulator
HM991_RS01700	COG1477	protein flavinylation
HM991_RS01705	COG3275	phosphorelay sensor kinase activity
HM991_RS01710	COG2972	Histidine kinase
HM991_RS01715	COG3279	Response regulator of the LytR AlgR family
HM991_RS01750	COG3275	phosphorelay sensor kinase activity
HM991_RS01755	COG3279	Response regulator of the LytR AlgR family
HM991_RS01775	COG2363	Small membrane protein
HM991_RS01780	COG2226	methyltransferase
HM991_RS01800	COG0427	acetyl-CoA hydrolase
HM991_RS01810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HM991_RS01820	COG3340	Belongs to the peptidase S51 family
HM991_RS01850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HM991_RS01885	COG1028	Short-chain dehydrogenase reductase Sdr
HM991_RS01910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HM991_RS01915	COG3844	kynureninase activity
HM991_RS01920	COG2205	protein histidine kinase activity
HM991_RS01920	COG0784	Response regulator, receiver
HM991_RS01950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HM991_RS01955	COG1663	tetraacyldisaccharide 4'-kinase activity
HM991_RS01960	COG0784	Response regulator, receiver
HM991_RS01960	COG2205	protein histidine kinase activity
HM991_RS01965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HM991_RS01970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HM991_RS02000	COG1595	DNA-templated transcription, initiation
HM991_RS02005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HM991_RS02010	COG0436	Aminotransferase
HM991_RS02020	COG0525	valine-tRNA ligase activity
HM991_RS02025	COG0772	Belongs to the SEDS family
HM991_RS02030	COG0768	penicillin binding
HM991_RS02045	COG1077	Cell shape determining protein MreB Mrl
HM991_RS02050	COG0138	bifunctional purine biosynthesis protein purh
HM991_RS02095	COG0459	protein refolding
HM991_RS02100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HM991_RS02130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM991_RS02155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM991_RS02185	COG0488	(ABC) transporter
HM991_RS02305	COG2732	(Barnase) inhibitor
HM991_RS02400	COG4974	Belongs to the 'phage' integrase family
HM991_RS02430	COG0784	Response regulator, receiver
HM991_RS02435	COG4251	negative regulation of phosphorylation
HM991_RS02475	COG0101	tRNA pseudouridine synthase activity
HM991_RS02480	COG1132	(ABC) transporter
HM991_RS02505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HM991_RS02520	COG0601	transmembrane transport
HM991_RS02525	COG0149	triose-phosphate isomerase activity
HM991_RS02535	COG2264	protein methyltransferase activity
HM991_RS02555	COG0730	response to heat
HM991_RS02615	COG3609	addiction module antidote protein, CC2985 family
HM991_RS02670	COG2356	endonuclease I
HM991_RS02695	COG0174	glutamine synthetase
HM991_RS02715	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HM991_RS02725	COG1129	ABC transporter
HM991_RS02735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HM991_RS02740	COG0681	Belongs to the peptidase S26 family
HM991_RS02745	COG0284	orotidine-5'-phosphate decarboxylase activity
HM991_RS02750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HM991_RS02775	COG0788	formyltetrahydrofolate deformylase activity
HM991_RS02780	COG1703	isobutyryl-CoA mutase activity
HM991_RS02780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM991_RS02780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM991_RS02790	COG1595	DNA-templated transcription, initiation
HM991_RS02805	COG1522	sequence-specific DNA binding
HM991_RS02810	COG0492	ferredoxin-NADP+ reductase activity
HM991_RS02830	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HM991_RS02855	COG2244	polysaccharide biosynthetic process
HM991_RS02880	COG1216	Glycosyl transferase, family 2
HM991_RS02890	COG2884	Cell division ATP-binding protein ftsE
HM991_RS02895	COG0133	tryptophan synthase activity
HM991_RS02900	COG0135	phosphoribosylanthranilate isomerase activity
HM991_RS02905	COG0134	indole-3-glycerol-phosphate synthase activity
HM991_RS02910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HM991_RS02915	COG0512	Glutamine amidotransferase of anthranilate synthase
HM991_RS02920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HM991_RS02935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HM991_RS02950	COG3852	Histidine kinase
HM991_RS02965	COG1136	(ABC) transporter
HM991_RS02965	COG0577	efflux transmembrane transporter activity
HM991_RS02970	COG0577	efflux transmembrane transporter activity
HM991_RS02970	COG1136	(ABC) transporter
HM991_RS02975	COG0577	efflux transmembrane transporter activity
HM991_RS02980	COG0577	efflux transmembrane transporter activity
HM991_RS02985	COG0577	efflux transmembrane transporter activity
HM991_RS03000	COG1136	(ABC) transporter
HM991_RS03020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM991_RS03025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM991_RS03030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM991_RS03040	COG1047	Peptidyl-prolyl cis-trans
HM991_RS03055	COG1349	DNA-binding transcription factor activity
HM991_RS03060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HM991_RS03065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HM991_RS03070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HM991_RS03080	COG4771	TonB-dependent receptor
HM991_RS03155	COG2949	membrane
HM991_RS03210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HM991_RS03270	COG0438	transferase activity, transferring glycosyl groups
HM991_RS03275	COG0438	transferase activity, transferring glycosyl groups
HM991_RS03280	COG1090	epimerase
HM991_RS03285	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HM991_RS03285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HM991_RS03300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HM991_RS03320	COG4585	Histidine kinase
HM991_RS03325	COG4585	Histidine kinase
HM991_RS03330	COG2197	response regulator
HM991_RS03360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HM991_RS03365	COG0484	heat shock protein binding
HM991_RS03370	COG4152	abc transporter atp-binding protein
HM991_RS03375	COG1668	transmembrane transport
HM991_RS03380	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HM991_RS03380	COG3264	Mechanosensitive ion channel
HM991_RS03390	COG2326	polyphosphate kinase activity
HM991_RS03410	COG0019	diaminopimelate decarboxylase activity
HM991_RS03420	COG0045	succinate-CoA ligase (ADP-forming) activity
HM991_RS03430	COG2819	hydrolase of the alpha beta superfamily
HM991_RS03440	COG0556	nucleotide-excision repair
HM991_RS03500	COG1131	(ABC) transporter
HM991_RS03515	COG1612	heme a metabolic process
HM991_RS03520	COG0517	IMP dehydrogenase activity
HM991_RS03520	COG0617	tRNA 3'-terminal CCA addition
HM991_RS03520	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HM991_RS03540	COG0463	Glycosyl transferase, family 2
HM991_RS03545	COG1216	Glycosyl transferase, family 2
HM991_RS03565	COG2171	N-acyltransferase activity
HM991_RS03570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HM991_RS03575	COG0242	peptide deformylase activity
HM991_RS03585	COG3956	TIGRFAM MazG family protein
HM991_RS03600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HM991_RS03620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM991_RS03630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HM991_RS03640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HM991_RS03650	COG0300	oxidoreductase activity
HM991_RS03655	COG0501	Belongs to the peptidase M48B family
HM991_RS03660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM991_RS03690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM991_RS03700	COG4106	trans-aconitate 2-methyltransferase activity
HM991_RS03705	COG5520	Belongs to the glycosyl hydrolase 30 family
HM991_RS03710	COG2195	Cleaves the N-terminal amino acid of tripeptides
HM991_RS03715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM991_RS03725	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HM991_RS03730	COG0105	UTP biosynthetic process
HM991_RS03735	COG1028	Short-chain dehydrogenase reductase Sdr
HM991_RS03745	COG1309	transcriptional regulator
HM991_RS03765	COG3275	phosphorelay sensor kinase activity
HM991_RS03785	COG3279	Response regulator of the LytR AlgR family
HM991_RS03820	COG4206	TonB-dependent receptor
HM991_RS03865	COG3591	Belongs to the peptidase S1B family
HM991_RS03875	COG1234	tRNA 3'-trailer cleavage
HM991_RS03910	COG2032	superoxide dismutase activity
HM991_RS03920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HM991_RS03925	COG0589	response to stress
HM991_RS03945	COG0348	domain, Protein
HM991_RS03950	COG2010	Cytochrome c
HM991_RS03970	COG2217	Heavy metal translocating P-type atpase
HM991_RS04010	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HM991_RS04015	COG3387	PFAM Glycoside hydrolase 15-related
HM991_RS04040	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM991_RS04045	COG1960	acyl-CoA dehydrogenase activity
HM991_RS04055	COG0183	Belongs to the thiolase family
HM991_RS04060	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM991_RS04060	COG1024	Enoyl-CoA hydratase
HM991_RS04065	COG1846	Transcriptional regulator
HM991_RS04070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HM991_RS04095	COG2356	endonuclease I
HM991_RS04105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HM991_RS04105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HM991_RS04110	COG1595	DNA-templated transcription, initiation
HM991_RS04210	COG1595	DNA-templated transcription, initiation
HM991_RS04215	COG1132	(ABC) transporter
HM991_RS04220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HM991_RS04235	COG0254	rRNA binding
HM991_RS04250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM991_RS04275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HM991_RS04285	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HM991_RS04290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HM991_RS04300	COG1607	acyl-coa hydrolase
HM991_RS04320	COG1120	ATPase activity
HM991_RS04325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HM991_RS04430	COG0564	pseudouridine synthase activity
HM991_RS04435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HM991_RS04460	COG2855	membrane
HM991_RS04465	COG0583	DNA-binding transcription factor activity
HM991_RS04470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HM991_RS04485	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HM991_RS04495	COG1295	ribonuclease BN
HM991_RS04500	COG3279	Response regulator of the LytR AlgR family
HM991_RS04505	COG2972	Histidine kinase
HM991_RS04505	COG0745	RESPONSE REGULATOR receiver
HM991_RS04530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HM991_RS04535	COG3279	Response regulator of the LytR AlgR family
HM991_RS04540	COG0360	Binds together with S18 to 16S ribosomal RNA
HM991_RS04545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HM991_RS04550	COG0359	binds to the 23S rRNA
HM991_RS04555	COG0584	glycerophosphoryl diester phosphodiesterase
HM991_RS04565	COG0577	efflux transmembrane transporter activity
HM991_RS04570	COG0124	histidyl-tRNA synthetase
HM991_RS04615	COG3275	phosphorelay sensor kinase activity
HM991_RS04620	COG3279	Response regulator of the LytR AlgR family
HM991_RS04625	COG0471	metal ion transport
HM991_RS04640	COG3665	Urea carboxylase-associated protein
HM991_RS04670	COG4251	negative regulation of phosphorylation
HM991_RS04685	COG1028	Short-chain dehydrogenase reductase Sdr
HM991_RS04705	COG4585	Histidine kinase
HM991_RS04730	COG0732	type I restriction modification DNA specificity domain
HM991_RS04730	COG0827	DNA restriction-modification system
HM991_RS04790	COG1678	Uncharacterized ACR, COG1678
HM991_RS04800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HM991_RS04805	COG0514	ATP-dependent DNA helicase (RecQ)
HM991_RS04825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HM991_RS04835	COG0415	Belongs to the DNA photolyase family
HM991_RS04855	COG0386	Belongs to the glutathione peroxidase family
HM991_RS04870	COG0302	gtp cyclohydrolase
HM991_RS04880	COG0702	epimerase
HM991_RS04895	COG0798	PFAM Bile acid sodium symporter
HM991_RS04920	COG0673	inositol 2-dehydrogenase activity
HM991_RS04945	COG0598	Magnesium transport protein CorA
HM991_RS04960	COG0424	maF-like protein
HM991_RS04990	COG1970	mechanosensitive ion channel activity
HM991_RS04995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HM991_RS04995	COG1333	cytochrome c biogenesis protein
HM991_RS05010	COG0626	cystathionine gamma-synthase activity
HM991_RS05020	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HM991_RS05025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HM991_RS05035	COG2234	aminopeptidase activity
HM991_RS05040	COG4935	Belongs to the peptidase S8 family
HM991_RS05040	COG2234	aminopeptidase activity
HM991_RS05170	COG1136	(ABC) transporter
HM991_RS05175	COG0577	efflux transmembrane transporter activity
HM991_RS05175	COG1136	(ABC) transporter
HM991_RS05195	COG5002	protein histidine kinase activity
HM991_RS05205	COG0589	response to stress
HM991_RS05230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HM991_RS05280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM991_RS05285	COG3292	Two component regulator propeller
HM991_RS05285	COG0745	RESPONSE REGULATOR receiver
HM991_RS05285	COG2205	protein histidine kinase activity
HM991_RS05290	COG0745	RESPONSE REGULATOR receiver
HM991_RS05290	COG3292	Two component regulator propeller
HM991_RS05290	COG2205	protein histidine kinase activity
HM991_RS05320	COG1360	Flagellar Motor Protein
HM991_RS05365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM991_RS05365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM991_RS05380	COG1674	ftsk spoiiie
HM991_RS05390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HM991_RS05395	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HM991_RS05420	COG0339	signal peptide processing
HM991_RS05430	COG0494	nUDIX hydrolase
HM991_RS05495	COG0693	protein deglycase activity
HM991_RS05500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HM991_RS05505	COG0318	PFAM AMP-dependent synthetase and ligase
HM991_RS05510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HM991_RS05515	COG0367	asparagine synthase
HM991_RS05530	COG0308	aminopeptidase N
HM991_RS05575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HM991_RS05590	COG0714	Associated with various cellular activities
HM991_RS05620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM991_RS05635	COG1233	COG1233 Phytoene dehydrogenase and related
HM991_RS05660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HM991_RS05665	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HM991_RS05675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HM991_RS05695	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HM991_RS05700	COG3959	Transketolase, thiamine diphosphate binding domain
HM991_RS05705	COG0343	queuine tRNA-ribosyltransferase activity
HM991_RS05720	COG0825	malonyl-CoA metabolic process
HM991_RS05725	COG0305	Participates in initiation and elongation during chromosome replication
HM991_RS05745	COG0432	Pfam Uncharacterised protein family UPF0047
HM991_RS05750	COG0561	phosphatase activity
HM991_RS05760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HM991_RS05765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HM991_RS05770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HM991_RS05775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HM991_RS05840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM991_RS05845	COG1960	acyl-CoA dehydrogenase activity
HM991_RS05865	COG0811	peptide transport
HM991_RS05870	COG0848	biopolymer transport protein
HM991_RS05880	COG0285	dihydrofolate synthase activity
HM991_RS05900	COG1556	Lactate utilization protein
HM991_RS05905	COG1139	Iron-sulfur cluster binding protein
HM991_RS05910	COG0247	lactate metabolic process
HM991_RS05915	COG0738	Major facilitator superfamily
HM991_RS05920	COG1012	belongs to the aldehyde dehydrogenase family
HM991_RS05925	COG4977	sequence-specific DNA binding
HM991_RS05930	COG0235	Class ii aldolase
HM991_RS05935	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
HM991_RS05945	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HM991_RS05950	COG3292	Two component regulator propeller
HM991_RS05950	COG0745	RESPONSE REGULATOR receiver
HM991_RS05950	COG2205	protein histidine kinase activity
HM991_RS05970	COG3119	arylsulfatase activity
HM991_RS05990	COG3119	arylsulfatase activity
HM991_RS05995	COG3119	arylsulfatase activity
HM991_RS06005	COG3119	arylsulfatase activity
HM991_RS06010	COG3119	arylsulfatase activity
HM991_RS06010	COG3408	Glycogen debranching enzyme
HM991_RS06020	COG3119	arylsulfatase activity
HM991_RS06040	COG3119	arylsulfatase activity
HM991_RS06050	COG3119	arylsulfatase activity
HM991_RS06055	COG3119	arylsulfatase activity
HM991_RS06070	COG3119	arylsulfatase activity
HM991_RS06075	COG3119	arylsulfatase activity
HM991_RS06080	COG3119	arylsulfatase activity
HM991_RS06110	COG3119	arylsulfatase activity
HM991_RS06115	COG3119	arylsulfatase activity
HM991_RS06120	COG3119	arylsulfatase activity
HM991_RS06130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM991_RS06140	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HM991_RS06145	COG0671	phosphoesterase, PA-phosphatase related
HM991_RS06150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HM991_RS06155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HM991_RS06170	COG0295	cytidine deaminase activity
HM991_RS06180	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM991_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
HM991_RS06195	COG0789	Transcriptional regulator
HM991_RS06240	COG1127	ABC transporter
HM991_RS06245	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HM991_RS06260	COG1216	Glycosyl transferase, family 2
HM991_RS06270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM991_RS06275	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HM991_RS06275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HM991_RS06320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HM991_RS06325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HM991_RS06330	COG0563	adenylate kinase activity
HM991_RS06340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HM991_RS06345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HM991_RS06375	COG3275	phosphorelay sensor kinase activity
HM991_RS06380	COG3279	Response regulator of the LytR AlgR family
HM991_RS06385	COG2373	Large extracellular alpha-helical protein
HM991_RS06395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HM991_RS06490	COG2003	Belongs to the UPF0758 family
HM991_RS06500	COG1011	Hydrolase
HM991_RS06510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HM991_RS06520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HM991_RS06535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HM991_RS06540	COG0049	tRNA binding
HM991_RS06545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HM991_RS06550	COG0051	transcription antitermination factor activity, RNA binding
HM991_RS06555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HM991_RS06560	COG0088	Forms part of the polypeptide exit tunnel
HM991_RS06565	COG0089	rRNA binding
HM991_RS06570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HM991_RS06575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HM991_RS06580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HM991_RS06585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HM991_RS06590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HM991_RS06595	COG0255	Belongs to the universal ribosomal protein uL29 family
HM991_RS06600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HM991_RS06605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HM991_RS06610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HM991_RS06615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HM991_RS06620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HM991_RS06625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HM991_RS06630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HM991_RS06635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HM991_RS06640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HM991_RS06645	COG1841	ribosomal large subunit assembly
HM991_RS06650	COG0200	Binds to the 23S rRNA
HM991_RS06655	COG0201	protein transport
HM991_RS06660	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HM991_RS06665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HM991_RS06670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HM991_RS06675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HM991_RS06680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HM991_RS06685	COG0202	RNA polymerase activity
HM991_RS06690	COG0203	ribosomal protein L17
HM991_RS06700	COG0148	phosphopyruvate hydratase activity
HM991_RS06730	COG0688	phosphatidylethanolamine metabolic process
HM991_RS06735	COG4589	Belongs to the CDS family
HM991_RS06745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HM991_RS06750	COG0799	negative regulation of ribosome biogenesis
HM991_RS06765	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HM991_RS06785	COG0189	ligase activity
HM991_RS06810	COG5002	protein histidine kinase activity
HM991_RS06815	COG0018	arginyl-trna synthetase
HM991_RS06830	COG3712	iron ion homeostasis
HM991_RS06845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HM991_RS06850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HM991_RS06865	COG1187	pseudouridine synthase activity
HM991_RS06885	COG0433	COG0433 Predicted ATPase
HM991_RS06890	COG0602	queuosine metabolic process
HM991_RS06905	COG0367	asparagine synthase
HM991_RS06920	COG0187	DNA topoisomerase II activity
HM991_RS06940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HM991_RS06960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HM991_RS06965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HM991_RS06970	COG0215	cysteine-tRNA ligase activity
HM991_RS06975	COG0302	gtp cyclohydrolase
HM991_RS07000	COG0442	prolyl-tRNA aminoacylation
HM991_RS07010	COG0268	Binds directly to 16S ribosomal RNA
HM991_RS07015	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HM991_RS07020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HM991_RS07045	COG1705	Flagellar rod assembly protein muramidase FlgJ
HM991_RS07045	COG1388	LysM domain
HM991_RS07050	COG1160	GTP binding
HM991_RS07070	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HM991_RS07080	COG1704	LemA family
HM991_RS07095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HM991_RS07125	COG4585	Histidine kinase
HM991_RS07140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HM991_RS07145	COG1181	Belongs to the D-alanine--D-alanine ligase family
HM991_RS07155	COG0564	pseudouridine synthase activity
HM991_RS07160	COG3022	response to hydroperoxide
HM991_RS07185	COG2197	response regulator
HM991_RS07205	COG1132	(ABC) transporter
HM991_RS07255	COG0513	Belongs to the DEAD box helicase family
HM991_RS07265	COG4628	conserved protein (DUF2132)
HM991_RS07275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HM991_RS07280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HM991_RS07295	COG0159	tryptophan synthase activity
HM991_RS07315	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HM991_RS07350	COG0584	glycerophosphoryl diester phosphodiesterase
HM991_RS07355	COG3876	Protein conserved in bacteria
HM991_RS07360	COG0577	efflux transmembrane transporter activity
HM991_RS07370	COG2264	protein methyltransferase activity
HM991_RS07380	COG2205	protein histidine kinase activity
HM991_RS07380	COG0784	Response regulator, receiver
HM991_RS07395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HM991_RS07400	COG1115	amino acid carrier protein
HM991_RS07410	COG1960	acyl-CoA dehydrogenase activity
HM991_RS07415	COG4974	Belongs to the 'phage' integrase family
HM991_RS07420	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HM991_RS07445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HM991_RS07465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HM991_RS07470	COG0081	regulation of translation
HM991_RS07475	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HM991_RS07480	COG0222	ribosome binding
HM991_RS07485	COG0085	RNA polymerase activity
HM991_RS07490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HM991_RS07505	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HM991_RS07510	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HM991_RS07520	COG1482	cell wall glycoprotein biosynthetic process
HM991_RS07570	COG1073	alpha beta
HM991_RS07625	COG0513	Belongs to the DEAD box helicase family
HM991_RS07630	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HM991_RS07645	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HM991_RS07650	COG2258	MOSC domain
HM991_RS07675	COG1629	transport
HM991_RS07680	COG0326	Molecular chaperone. Has ATPase activity
HM991_RS07685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM991_RS07695	COG1228	amidohydrolase
HM991_RS07715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HM991_RS07725	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM991_RS07735	COG1342	Belongs to the UPF0251 family
HM991_RS07745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM991_RS07745	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM991_RS07750	COG0824	Thioesterase
HM991_RS07765	COG0179	Fumarylacetoacetate (FAA) hydrolase
HM991_RS07775	COG1058	Belongs to the CinA family
HM991_RS07775	COG1546	Belongs to the CinA family
HM991_RS07780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HM991_RS07785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HM991_RS07795	COG0552	protein localization to endoplasmic reticulum
HM991_RS07810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HM991_RS07815	COG0656	L-ascorbic acid biosynthetic process
HM991_RS07855	COG0612	Peptidase, M16
HM991_RS07865	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HM991_RS07880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HM991_RS07880	COG0519	Catalyzes the synthesis of GMP from XMP
HM991_RS07900	COG0504	CTP synthase activity
HM991_RS07905	COG0706	membrane insertase activity
HM991_RS07915	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM991_RS07925	COG0482	sulfurtransferase activity
HM991_RS07940	COG3263	regulation of cellular component size
HM991_RS07950	COG0534	Mate efflux family protein
HM991_RS07960	COG0671	phosphoesterase, PA-phosphatase related
HM991_RS07965	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM991_RS07965	COG3952	Lipid A Biosynthesis
HM991_RS07970	COG0463	Glycosyl transferase, family 2
HM991_RS07985	COG1595	DNA-templated transcription, initiation
HM991_RS08020	COG0823	Involved in the tonB-independent uptake of proteins
HM991_RS08020	COG1506	peptidase
HM991_RS08220	COG3291	Pkd domain containing protein
HM991_RS08245	COG0653	protein targeting
HM991_RS08260	COG1136	(ABC) transporter
HM991_RS08270	COG0488	(ABC) transporter
HM991_RS08280	COG3206	protein involved in exopolysaccharide biosynthesis
HM991_RS08280	COG0489	protein tyrosine kinase activity
HM991_RS08285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM991_RS08290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HM991_RS08300	COG2852	Protein conserved in bacteria
HM991_RS08325	COG3551	Protein conserved in bacteria
HM991_RS08340	COG1215	transferase activity, transferring glycosyl groups
HM991_RS08340	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HM991_RS08350	COG1215	transferase activity, transferring glycosyl groups
HM991_RS08360	COG1216	Glycosyl transferase, family 2
HM991_RS08375	COG0438	transferase activity, transferring glycosyl groups
HM991_RS08390	COG0438	transferase activity, transferring glycosyl groups
HM991_RS08395	COG0438	transferase activity, transferring glycosyl groups
HM991_RS08410	COG0438	transferase activity, transferring glycosyl groups
HM991_RS08450	COG0438	transferase activity, transferring glycosyl groups
HM991_RS08455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM991_RS08470	COG1183	phosphatidylcholine synthase activity
HM991_RS08475	COG2354	Protein conserved in bacteria
HM991_RS08485	COG1137	ATPase activity
HM991_RS08495	COG0805	protein transport
HM991_RS08500	COG0517	IMP dehydrogenase activity
HM991_RS08500	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HM991_RS08505	COG0514	ATP-dependent DNA helicase (RecQ)
HM991_RS08520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HM991_RS08550	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HM991_RS08560	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HM991_RS08575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HM991_RS08605	COG0681	Belongs to the peptidase S26 family
HM991_RS08610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HM991_RS08620	COG1475	DNA binding
HM991_RS08625	COG1192	Involved in chromosome partitioning
HM991_RS08630	COG0612	Peptidase, M16
HM991_RS08635	COG0492	ferredoxin-NADP+ reductase activity
HM991_RS08635	COG3118	belongs to the thioredoxin family
HM991_RS08645	COG0612	Peptidase, M16
HM991_RS08650	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM991_RS08650	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM991_RS08655	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM991_RS08665	COG0572	uridine kinase
HM991_RS08670	COG2010	Cytochrome c
HM991_RS08675	COG2133	pyrroloquinoline quinone binding
HM991_RS08715	COG1858	cytochrome C peroxidase
HM991_RS08745	COG0385	Bile acid
HM991_RS08755	COG1012	belongs to the aldehyde dehydrogenase family
HM991_RS08795	COG0492	ferredoxin-NADP+ reductase activity
HM991_RS08860	COG0783	Belongs to the Dps family
HM991_RS08875	COG0714	Associated with various cellular activities
HM991_RS08910	COG0071	Belongs to the small heat shock protein (HSP20) family
HM991_RS08925	COG1538	Outer membrane efflux protein
HM991_RS08955	COG2226	methyltransferase
HM991_RS08960	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HM991_RS08960	COG0116	Belongs to the methyltransferase superfamily
HM991_RS08970	COG2326	polyphosphate kinase activity
HM991_RS08975	COG2326	polyphosphate kinase activity
HM991_RS08995	COG1611	Belongs to the LOG family
HM991_RS09025	COG0179	Fumarylacetoacetate (FAA) hydrolase
HM991_RS09070	COG0793	Belongs to the peptidase S41A family
HM991_RS09070	COG4946	Tricorn protease homolog
HM991_RS09080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HM991_RS09095	COG1560	Kdo2-lipid A biosynthetic process
HM991_RS09110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM991_RS09120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HM991_RS09200	COG2217	Heavy metal translocating P-type atpase
HM991_RS09210	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HM991_RS09220	COG2132	Multicopper oxidase
HM991_RS09235	COG2217	Heavy metal translocating P-type atpase
HM991_RS09295	COG2202	Pas domain
HM991_RS09295	COG2205	protein histidine kinase activity
HM991_RS09325	COG3273	potassium ion transport
HM991_RS09325	COG0471	metal ion transport
HM991_RS09345	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HM991_RS09350	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HM991_RS09390	COG3321	synthase
HM991_RS09390	COG0300	oxidoreductase activity
HM991_RS09390	COG0318	PFAM AMP-dependent synthetase and ligase
HM991_RS09390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HM991_RS09390	COG1028	Short-chain dehydrogenase reductase Sdr
HM991_RS09405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HM991_RS09405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM991_RS09405	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HM991_RS09405	COG3321	synthase
HM991_RS09410	COG2091	lysine biosynthetic process via aminoadipic acid
HM991_RS09440	COG0450	alkyl hydroperoxide reductase
HM991_RS09445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HM991_RS09445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HM991_RS09460	COG1271	oxidase subunit
HM991_RS09465	COG1294	oxidase, subunit
HM991_RS09495	COG1131	(ABC) transporter
HM991_RS09500	COG1131	(ABC) transporter
HM991_RS09505	COG0842	Transport permease protein
HM991_RS09510	COG0842	Transport permease protein
HM991_RS09530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HM991_RS09535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HM991_RS09540	COG1335	isochorismatase
HM991_RS09545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HM991_RS09560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM991_RS09585	COG0592	DNA-directed DNA polymerase activity
HM991_RS09615	COG1702	phosphate starvation-inducible protein PhoH
HM991_RS09625	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HM991_RS09645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HM991_RS09650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HM991_RS09680	COG1104	cysteine desulfurase activity
HM991_RS09715	COG1418	mRNA catabolic process
HM991_RS09720	COG2205	protein histidine kinase activity
HM991_RS09720	COG0745	RESPONSE REGULATOR receiver
HM991_RS09720	COG3292	Two component regulator propeller
HM991_RS09725	COG4974	Belongs to the 'phage' integrase family
HM991_RS09745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HM991_RS09765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HM991_RS09785	COG0813	purine-nucleoside phosphorylase activity
HM991_RS09790	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HM991_RS09795	COG0542	response to heat
HM991_RS09815	COG0564	pseudouridine synthase activity
HM991_RS09820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HM991_RS09825	COG0540	Belongs to the ATCase OTCase family
HM991_RS09835	COG1234	tRNA 3'-trailer cleavage
HM991_RS09845	COG0259	pyridoxamine-phosphate oxidase activity
HM991_RS09885	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HM991_RS09915	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HM991_RS09925	COG0742	ribosomal rna small subunit methyltransferase
HM991_RS09940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HM991_RS09950	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HM991_RS09965	COG1454	alcohol dehydrogenase
HM991_RS10015	COG1115	amino acid carrier protein
HM991_RS10020	COG4977	sequence-specific DNA binding
HM991_RS10025	COG1012	belongs to the aldehyde dehydrogenase family
HM991_RS10050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HM991_RS10060	COG5002	protein histidine kinase activity
HM991_RS10065	COG0745	RESPONSE REGULATOR receiver
HM991_RS10080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HM991_RS10090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HM991_RS10095	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM991_RS10115	COG1393	Belongs to the ArsC family
HM991_RS10130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HM991_RS10195	COG3279	Response regulator of the LytR AlgR family
HM991_RS10200	COG2972	Histidine kinase
HM991_RS10200	COG0745	RESPONSE REGULATOR receiver
HM991_RS10205	COG0156	8-amino-7-oxononanoate synthase activity
HM991_RS10255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HM991_RS10275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HM991_RS10280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HM991_RS10340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HM991_RS10355	COG0823	Involved in the tonB-independent uptake of proteins
HM991_RS10355	COG4946	Tricorn protease homolog
HM991_RS10355	COG1506	peptidase
HM991_RS10385	COG0300	oxidoreductase activity
HM991_RS10395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HM991_RS10405	COG0488	(ABC) transporter
HM991_RS10420	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HM991_RS10430	COG1119	ATPase activity
HM991_RS10445	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HM991_RS10485	COG1131	(ABC) transporter
HM991_RS10675	COG0450	alkyl hydroperoxide reductase
HM991_RS10690	COG1522	sequence-specific DNA binding
HM991_RS10705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HM991_RS10710	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HM991_RS10725	COG3279	Response regulator of the LytR AlgR family
HM991_RS10760	COG0010	Belongs to the arginase family
HM991_RS10770	COG1228	amidohydrolase
HM991_RS10795	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HM991_RS10820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HM991_RS10825	COG2382	esterase
HM991_RS10885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM991_RS10890	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HM991_RS10900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HM991_RS10915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM991_RS10920	COG0577	efflux transmembrane transporter activity
HM991_RS10920	COG1136	(ABC) transporter
HM991_RS10925	COG1136	(ABC) transporter
HM991_RS10925	COG0577	efflux transmembrane transporter activity
HM991_RS10955	COG3279	Response regulator of the LytR AlgR family
HM991_RS11000	COG0012	GTP binding
HM991_RS11030	COG0861	Integral membrane protein TerC family
HM991_RS11050	COG1522	sequence-specific DNA binding
HM991_RS11060	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HM991_RS11065	COG0506	proline dehydrogenase activity
HM991_RS11085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HM991_RS11100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HM991_RS11110	COG0367	asparagine synthase
HM991_RS11115	COG0438	transferase activity, transferring glycosyl groups
HM991_RS11125	COG0110	maltose O-acetyltransferase activity
HM991_RS11140	COG1442	glycosyl transferase family 8
HM991_RS11140	COG1216	Glycosyl transferase, family 2
HM991_RS11145	COG0367	asparagine synthase
HM991_RS11155	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HM991_RS11185	COG0802	atpase or kinase
HM991_RS11190	COG2197	response regulator
HM991_RS11195	COG1078	dGTPase activity
HM991_RS11200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM991_RS11205	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HM991_RS11205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HM991_RS11210	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM991_RS11215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HM991_RS11230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HM991_RS11235	COG1028	Short-chain dehydrogenase reductase Sdr
HM991_RS11250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HM991_RS11255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HM991_RS11260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HM991_RS11265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HM991_RS11265	COG0131	Imidazoleglycerol-phosphate dehydratase
HM991_RS11275	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HM991_RS11280	COG0107	imidazoleglycerol-phosphate synthase activity
HM991_RS11285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HM991_RS11285	COG0140	phosphoribosyl-ATP diphosphatase activity
HM991_RS11310	COG0101	tRNA pseudouridine synthase activity
HM991_RS11320	COG0668	transmembrane transport
HM991_RS11350	COG0668	transmembrane transport
HM991_RS11355	COG2814	Major facilitator Superfamily
HM991_RS11370	COG1278	Cold shock
HM991_RS11375	COG3011	Protein conserved in bacteria
HM991_RS11380	COG1193	negative regulation of DNA recombination
HM991_RS11385	COG1288	antiporter activity
HM991_RS11390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HM991_RS11400	COG0813	purine-nucleoside phosphorylase activity
HM991_RS11420	COG0022	dehydrogenase e1 component
HM991_RS11450	COG1187	pseudouridine synthase activity
HM991_RS11470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HM991_RS11515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HM991_RS11520	COG0280	phosphate acetyltransferase
HM991_RS11520	COG0857	belongs to the CobB CobQ family
HM991_RS11525	COG1278	Cold shock
HM991_RS11540	COG1278	Cold shock
HM991_RS11550	COG0513	Belongs to the DEAD box helicase family
HM991_RS11560	COG4181	ATPase activity
HM991_RS11565	COG0577	efflux transmembrane transporter activity
HM991_RS11565	COG1136	(ABC) transporter
HM991_RS11580	COG0322	excinuclease ABC activity
HM991_RS11585	COG3237	CsbD-like
HM991_RS11595	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HM991_RS11605	COG1902	pentaerythritol trinitrate reductase activity
HM991_RS11620	COG2308	Evidence 4 Homologs of previously reported genes of
HM991_RS11645	COG2308	Evidence 4 Homologs of previously reported genes of
HM991_RS11645	COG2307	Protein conserved in bacteria
HM991_RS11655	COG2066	Belongs to the glutaminase family
HM991_RS11665	COG0352	thiamine-phosphate diphosphorylase activity
HM991_RS11675	COG1979	alcohol dehydrogenase
HM991_RS11680	COG2130	NADP-dependent
HM991_RS11695	COG1309	transcriptional regulator
HM991_RS11705	COG1733	regulation of RNA biosynthetic process
HM991_RS11720	COG2095	MarC family integral membrane protein
HM991_RS11725	COG0346	lactoylglutathione lyase activity
HM991_RS11730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HM991_RS11740	COG4770	biotin carboxylase activity
HM991_RS11745	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HM991_RS11750	COG0427	acetyl-CoA hydrolase
HM991_RS11755	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM991_RS11760	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM991_RS11760	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HM991_RS11770	COG1703	isobutyryl-CoA mutase activity
HM991_RS11775	COG0469	pyruvate kinase activity
HM991_RS11785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HM991_RS11805	COG0246	Mannitol dehydrogenase
HM991_RS11820	COG2814	Major facilitator Superfamily
HM991_RS11825	COG4251	negative regulation of phosphorylation
HM991_RS11835	COG1770	oligopeptidase
HM991_RS11855	COG3621	Patatin-like phospholipase
HM991_RS11885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HM991_RS11900	COG3279	Response regulator of the LytR AlgR family
HM991_RS11910	COG1131	(ABC) transporter
HM991_RS11940	COG1012	belongs to the aldehyde dehydrogenase family
HM991_RS11945	COG1278	Cold shock
HM991_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
HM991_RS11970	COG0484	heat shock protein binding
HM991_RS12000	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM991_RS12005	COG4771	TonB-dependent receptor
HM991_RS12020	COG1301	dicarboxylic acid transport
HM991_RS12025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HM991_RS12035	COG0247	lactate metabolic process
HM991_RS12035	COG0277	FAD linked oxidase domain protein
HM991_RS12075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HM991_RS12085	COG2154	pterin-4-alpha-carbinolamine dehydratase
HM991_RS12090	COG0217	transcriptional regulatory protein
HM991_RS12125	COG1629	transport
HM991_RS12140	COG4948	Mandelate Racemase Muconate Lactonizing
HM991_RS12155	COG0564	pseudouridine synthase activity
HM991_RS12160	COG1032	radical SAM domain protein
HM991_RS12165	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HM991_RS12175	COG1575	Belongs to the MenA family. Type 1 subfamily
HM991_RS12190	COG2996	Protein conserved in bacteria
HM991_RS12200	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HM991_RS12220	COG2201	protein-glutamate methylesterase activity
HM991_RS12225	COG4191	Histidine kinase
HM991_RS12260	COG2070	2-Nitropropane dioxygenase
HM991_RS12265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HM991_RS12290	COG0443	Heat shock 70 kDa protein
HM991_RS12305	COG1760	l-serine dehydratase
HM991_RS12315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HM991_RS12320	COG0564	pseudouridine synthase activity
HM991_RS12325	COG4585	Histidine kinase
HM991_RS12340	COG1984	allophanate hydrolase subunit 2
HM991_RS12345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HM991_RS12355	COG1914	H( )-stimulated, divalent metal cation uptake system
HM991_RS12365	COG0606	chelatase, subunit chli
HM991_RS12405	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HM991_RS12410	COG0037	tRNA processing
HM991_RS12500	COG0488	(ABC) transporter
HM991_RS12510	COG1846	Transcriptional regulator
HM991_RS12515	COG2388	GCN5-related N-acetyl-transferase
HM991_RS12525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HM991_RS12570	COG0205	6-phosphofructokinase activity
HM991_RS12580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HM991_RS12610	COG0628	permease
HM991_RS12660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HM991_RS12675	COG2205	protein histidine kinase activity
HM991_RS12675	COG0784	Response regulator, receiver
HM991_RS12680	COG0745	RESPONSE REGULATOR receiver
HM991_RS12730	COG0484	heat shock protein binding
HM991_RS12755	COG0531	amino acid
HM991_RS12765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HM991_RS12770	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM991_RS12770	COG1024	Enoyl-CoA hydratase
HM991_RS12780	COG2823	Periplasmic or secreted lipoprotein
HM991_RS12805	COG0588	phosphoglycerate mutase activity
HM991_RS12820	COG3174	membrane
HM991_RS12835	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HM991_RS12855	COG0589	response to stress
HM991_RS12875	COG1480	7TM receptor with intracellular HD hydrolase
HM991_RS12880	COG0183	Belongs to the thiolase family
HM991_RS12885	COG0791	NLP P60 protein
HM991_RS12900	COG0542	response to heat
HM991_RS12910	COG2986	histidine ammonia-lyase
HM991_RS12920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HM991_RS12925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HM991_RS12930	COG0460	homoserine dehydrogenase
HM991_RS12930	COG0527	aspartate kinase activity
HM991_RS12935	COG0083	homoserine kinase activity
HM991_RS12940	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HM991_RS12985	COG0516	GMP reductase activity
HM991_RS12985	COG0517	IMP dehydrogenase activity
HM991_RS12995	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HM991_RS13045	COG0167	dihydroorotate dehydrogenase activity
HM991_RS13050	COG0589	response to stress
HM991_RS13055	COG2195	Cleaves the N-terminal amino acid of tripeptides
HM991_RS13075	COG1862	Preprotein translocase
HM991_RS13085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HM991_RS13090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM991_RS13095	COG1132	(ABC) transporter
HM991_RS13110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM991_RS13130	COG0095	Lipoate-protein ligase
HM991_RS13150	COG1272	protein, Hemolysin III
HM991_RS13165	COG1131	(ABC) transporter
HM991_RS13170	COG1363	Peptidase, m42
HM991_RS13225	COG2339	peptidase activity
HM991_RS13235	COG0439	Biotin carboxylase
HM991_RS13240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HM991_RS13250	COG2814	Major facilitator Superfamily
HM991_RS13255	COG0009	L-threonylcarbamoyladenylate synthase
HM991_RS13270	COG1473	amidohydrolase
HM991_RS13285	COG3279	Response regulator of the LytR AlgR family
HM991_RS13290	COG3275	phosphorelay sensor kinase activity
HM991_RS13330	COG0438	transferase activity, transferring glycosyl groups
HM991_RS13335	COG1472	Belongs to the glycosyl hydrolase 3 family
HM991_RS13340	COG0560	Phosphoserine phosphatase
HM991_RS13340	COG3830	Belongs to the UPF0237 family
HM991_RS13380	COG2181	nitrate reductase activity
HM991_RS13380	COG0247	lactate metabolic process
HM991_RS13390	COG2181	nitrate reductase activity
HM991_RS13390	COG0247	lactate metabolic process
HM991_RS13400	COG0860	N-Acetylmuramoyl-L-alanine amidase
HM991_RS13410	COG0251	oxidation-reduction process
HM991_RS13435	COG0516	GMP reductase activity
HM991_RS13455	COG3104	oligopeptide transport
HM991_RS13460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HM991_RS13470	COG0791	NLP P60 protein
HM991_RS13470	COG1388	LysM domain
HM991_RS13475	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HM991_RS13515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HM991_RS13520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HM991_RS13525	COG0297	glycogen (starch) synthase activity
HM991_RS13530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HM991_RS13535	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HM991_RS13570	COG2936	dipeptidyl-peptidase activity
HM991_RS13580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HM991_RS13585	COG0673	inositol 2-dehydrogenase activity
HM991_RS13590	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM991_RS13605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HM991_RS13610	COG0322	excinuclease ABC activity
HM991_RS13620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HM991_RS13625	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HM991_RS13645	COG0237	dephospho-CoA kinase activity
HM991_RS13655	COG1216	Glycosyl transferase, family 2
HM991_RS13655	COG0463	Glycosyl transferase, family 2
HM991_RS13665	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HM991_RS13670	COG0497	DNA recombination
HM991_RS13695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HM991_RS13710	COG0737	Belongs to the 5'-nucleotidase family
HM991_RS13720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HM991_RS13730	COG2890	protein-(glutamine-N5) methyltransferase activity
HM991_RS13745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HM991_RS13745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HM991_RS13755	COG0697	spore germination
HM991_RS13765	COG1739	Uncharacterized protein family UPF0029
HM991_RS13770	COG0824	Thioesterase
HM991_RS13775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HM991_RS13780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HM991_RS13790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HM991_RS13805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HM991_RS13815	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HM991_RS13820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HM991_RS13840	COG0336	Belongs to the RNA methyltransferase TrmD family
HM991_RS13850	COG0335	large ribosomal subunit rRNA binding
HM991_RS13875	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HM991_RS13930	COG1629	transport
HM991_RS13935	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HM991_RS13965	COG0321	lipoyl(octanoyl) transferase activity
HM991_RS13975	COG0401	homolog of Blt101
HM991_RS13980	COG2197	response regulator
HM991_RS13995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HM991_RS14020	COG4682	membrane
HM991_RS14040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HM991_RS14050	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HM991_RS14075	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HM991_RS14085	COG0659	secondary active sulfate transmembrane transporter activity
HM991_RS14090	COG1278	Cold shock
HM991_RS14105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HM991_RS14110	COG0022	dehydrogenase e1 component
HM991_RS14115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HM991_RS14120	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM991_RS14150	COG2030	dehydratase
HM991_RS14150	COG1012	belongs to the aldehyde dehydrogenase family
HM991_RS14155	COG0183	Belongs to the thiolase family
HM991_RS14160	COG2321	neutral zinc metallopeptidase
HM991_RS14170	COG1250	3-hydroxyacyl-CoA dehydrogenase
HM991_RS14180	COG1024	Enoyl-CoA hydratase
HM991_RS14185	COG2151	metal-sulfur cluster biosynthetic enzyme
HM991_RS14190	COG3396	Phenylacetate-CoA oxygenase
HM991_RS14195	COG3460	Phenylacetate-CoA oxygenase
HM991_RS14200	COG3396	Phenylacetate-CoA oxygenase
HM991_RS14205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HM991_RS14250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HM991_RS14255	COG2197	response regulator
HM991_RS14260	COG0358	DNA primase activity
HM991_RS14270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HM991_RS14280	COG2076	Multidrug Resistance protein
HM991_RS14310	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HM991_RS14315	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HM991_RS14320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HM991_RS14340	COG1490	D-aminoacyl-tRNA deacylase activity
HM991_RS14345	COG1162	GTPase activity
HM991_RS14360	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HM991_RS14365	COG0287	Prephenate dehydrogenase
HM991_RS14370	COG0436	Aminotransferase
HM991_RS14375	COG0077	Prephenate dehydratase
HM991_RS14375	COG1605	Chorismate mutase
HM991_RS14380	COG1131	(ABC) transporter
HM991_RS14395	COG0633	Ferredoxin
HM991_RS14400	COG0492	ferredoxin-NADP+ reductase activity
HM991_RS14415	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HM991_RS14425	COG1959	2 iron, 2 sulfur cluster binding
HM991_RS14435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HM991_RS14440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HM991_RS14455	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HM991_RS14460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HM991_RS14470	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HM991_RS14475	COG2086	electron transfer activity
HM991_RS14480	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM991_RS14480	COG0022	dehydrogenase e1 component
HM991_RS14485	COG4771	TonB-dependent receptor
HM991_RS14495	COG1045	serine acetyltransferase
HM991_RS14500	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HM991_RS14505	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HM991_RS14550	COG1428	Deoxynucleoside kinase
HM991_RS14565	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HM991_RS14575	COG0745	RESPONSE REGULATOR receiver
HM991_RS14580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HM991_RS14585	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HM991_RS14595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM991_RS14600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HM991_RS14645	COG2211	Major facilitator Superfamily
HM991_RS14655	COG3250	beta-galactosidase activity
HM991_RS14680	COG0702	epimerase
HM991_RS14685	COG4771	TonB-dependent receptor
HM991_RS14690	COG3292	Two component regulator propeller
HM991_RS14690	COG0745	RESPONSE REGULATOR receiver
HM991_RS14690	COG2205	protein histidine kinase activity
HM991_RS14715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HM991_RS14730	COG1428	Deoxynucleoside kinase
HM991_RS14750	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HM991_RS14755	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HM991_RS14765	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HM991_RS14785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HM991_RS14795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HM991_RS14805	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HM991_RS14810	COG0596	Alpha beta hydrolase
HM991_RS14825	COG0544	peptidyl-prolyl cis-trans isomerase activity
HM991_RS14830	COG0740	serine-type endopeptidase activity
HM991_RS14835	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HM991_RS14860	COG0745	RESPONSE REGULATOR receiver
HM991_RS14860	COG2972	Histidine kinase
HM991_RS14910	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HM991_RS14925	COG0668	transmembrane transport
HM991_RS14930	COG1214	PFAM Peptidase M22, glycoprotease
HM991_RS14950	COG0577	efflux transmembrane transporter activity
HM991_RS14950	COG1136	(ABC) transporter
HM991_RS14955	COG0577	efflux transmembrane transporter activity
HM991_RS14955	COG1136	(ABC) transporter
HM991_RS14960	COG1136	(ABC) transporter
HM991_RS14970	COG2322	membrane
HM991_RS14975	COG1999	signal sequence binding
HM991_RS14995	COG1845	cytochrome c oxidase, subunit III
HM991_RS15000	COG0109	protoheme IX farnesyltransferase activity
HM991_RS15055	COG0509	glycine decarboxylation via glycine cleavage system
HM991_RS15065	COG0632	four-way junction helicase activity
HM991_RS15070	COG0280	phosphate acetyltransferase
HM991_RS15070	COG0281	malic enzyme
HM991_RS15075	COG2205	protein histidine kinase activity
HM991_RS15080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HM991_RS15085	COG2124	cytochrome p450
HM991_RS15090	COG2255	four-way junction helicase activity
HM991_RS15095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HM991_RS15100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HM991_RS15125	COG0437	4 iron, 4 sulfur cluster binding
HM991_RS15140	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HM991_RS15145	COG0195	Participates in both transcription termination and antitermination
HM991_RS15145	COG2251	uridine kinase activity
HM991_RS15150	COG0779	Required for maturation of 30S ribosomal subunits
HM991_RS15155	COG0589	response to stress
HM991_RS15180	COG1408	metallophosphoesterase
HM991_RS15190	COG1446	asparaginase
HM991_RS15220	COG1446	asparaginase
HM991_RS15230	COG3920	Histidine kinase
HM991_RS15250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM991_RS15250	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HM991_RS15260	COG1401	restriction endodeoxyribonuclease activity
HM991_RS15275	COG2852	Protein conserved in bacteria
HM991_RS15280	COG0488	(ABC) transporter
HM991_RS15290	COG0009	L-threonylcarbamoyladenylate synthase
HM991_RS15295	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HM991_RS15300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HM991_RS15305	COG0052	Belongs to the universal ribosomal protein uS2 family
HM991_RS15310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HM991_RS15315	COG0528	UMP kinase activity
HM991_RS15320	COG0233	cytoplasmic translational termination
HM991_RS15335	COG0017	Asparaginyl-tRNA synthetase
HM991_RS15340	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HM991_RS15360	COG0848	biopolymer transport protein
HM991_RS15370	COG0811	peptide transport
HM991_RS15380	COG0252	asparaginase activity
HM991_RS15385	COG0084	hydrolase, TatD family'
HM991_RS15430	COG0508	dehydrogenase complex catalyzes the overall conversion of
HM991_RS15450	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HM991_RS15455	COG4263	nitrous-oxide reductase activity
HM991_RS15545	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HM991_RS15550	COG1959	2 iron, 2 sulfur cluster binding
HM991_RS15560	COG0142	geranyltranstransferase activity
HM991_RS15565	COG1309	transcriptional regulator
HM991_RS15580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HM991_RS15585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HM991_RS15605	COG1278	Cold shock
HM991_RS15625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HM991_RS15630	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HM991_RS15670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HM991_RS15675	COG1328	CTP reductase activity
HM991_RS15675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HM991_RS15680	COG2204	response regulator
HM991_RS15685	COG3275	phosphorelay sensor kinase activity
HM991_RS15735	COG2095	MarC family integral membrane protein
HM991_RS15750	COG0793	Belongs to the peptidase S41A family
HM991_RS15770	COG0646	methionine synthase
HM991_RS15770	COG1410	methionine synthase
HM991_RS15780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HM991_RS15805	COG0800	Aldolase
HM991_RS15810	COG0205	6-phosphofructokinase activity
HM991_RS15820	COG1609	Transcriptional regulator
HM991_RS15835	COG0702	epimerase
HM991_RS15840	COG4771	TonB-dependent receptor
HM991_RS15845	COG1028	Short-chain dehydrogenase reductase Sdr
HM991_RS15850	COG2271	Major facilitator Superfamily
HM991_RS15855	COG2186	Transcriptional regulator
HM991_RS15865	COG0702	epimerase
HM991_RS15870	COG4771	TonB-dependent receptor
HM991_RS15915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HM991_RS15920	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HM991_RS15925	COG1752	Esterase of the alpha-beta hydrolase superfamily
HM991_RS15930	COG0322	excinuclease ABC activity
HM991_RS15935	COG4067	protein conserved in archaea
HM991_RS15935	COG0189	ligase activity
HM991_RS15940	COG0189	ligase activity
HM991_RS15950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HM991_RS15960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HM991_RS15975	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HM991_RS15980	COG5183	chlorophyll binding
HM991_RS15980	COG2133	pyrroloquinoline quinone binding
HM991_RS15985	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HM991_RS16010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HM991_RS16015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HM991_RS16020	COG0297	glycogen (starch) synthase activity
HM991_RS16030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HM991_RS16035	COG4206	TonB-dependent receptor
HM991_RS16035	COG1629	transport
HM991_RS16050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HM991_RS16055	COG0673	inositol 2-dehydrogenase activity
HM991_RS16070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HM991_RS16085	COG3655	Transcriptional regulator
HM991_RS16140	COG2268	Band 7 protein
HM991_RS16160	COG2137	regulation of response to DNA damage stimulus
HM991_RS16180	COG1381	Involved in DNA repair and RecF pathway recombination
HM991_RS16190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HM991_RS16200	COG0626	cystathionine gamma-synthase activity
HM991_RS16235	COG1561	YicC-like family, N-terminal region
HM991_RS16240	COG0194	GDP metabolic process
HM991_RS16245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HM991_RS16250	COG0792	nuclease activity
HM991_RS16265	COG1619	proteins homologs of microcin C7 resistance protein MccF
HM991_RS16275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM991_RS16275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HM991_RS16310	COG0123	including yeast histone deacetylase and acetoin utilization protein
HM991_RS16315	COG1528	Iron-storage protein
HM991_RS16335	COG0318	PFAM AMP-dependent synthetase and ligase
HM991_RS16340	COG2267	carboxylic ester hydrolase activity
HM991_RS16350	COG4771	TonB-dependent receptor
HM991_RS16355	COG0596	Alpha beta hydrolase
HM991_RS16360	COG1028	Short-chain dehydrogenase reductase Sdr
HM991_RS16365	COG4977	sequence-specific DNA binding
HM991_RS16385	COG0629	single-stranded DNA binding
HM991_RS16420	COG3586	endonuclease activity
HM991_RS16430	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HM991_RS16445	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HM991_RS16565	COG0516	GMP reductase activity
HM991_RS16565	COG0517	IMP dehydrogenase activity
HM991_RS16585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HM991_RS16600	COG1629	transport
HM991_RS16635	COG1999	signal sequence binding
HM991_RS16665	COG4771	TonB-dependent receptor
HM991_RS16670	COG0803	Belongs to the bacterial solute-binding protein 9 family
HM991_RS16675	COG1121	(ABC) transporter
HM991_RS16685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HM991_RS16690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HM991_RS16710	COG0484	heat shock protein binding
HM991_RS16735	COG1418	mRNA catabolic process
HM991_RS16750	COG2207	Transcriptional regulator
HM991_RS16770	COG1024	Enoyl-CoA hydratase
HM991_RS16790	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HM991_RS16815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HM991_RS16820	COG0181	hydroxymethylbilane synthase activity
HM991_RS16825	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HM991_RS16830	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HM991_RS16840	COG0408	coproporphyrinogen oxidase activity
HM991_RS16845	COG3012	SEC-C Motif Domain Protein
HM991_RS16855	COG0113	porphobilinogen synthase activity
HM991_RS16860	COG1522	sequence-specific DNA binding
HM991_RS16875	COG1253	flavin adenine dinucleotide binding
HM991_RS16880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HM991_RS16920	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HM991_RS16935	COG1774	PSP1 C-terminal conserved region
HM991_RS16950	COG0826	peptidase U32
HM991_RS16970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HM991_RS16995	COG0180	Tryptophanyl-tRNA synthetase
HM991_RS17010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HM991_RS17010	COG0758	DNA mediated transformation
HM991_RS17045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HM991_RS17055	COG0756	dUTP diphosphatase activity
HM991_RS17070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HM991_RS17075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HM991_RS17080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HM991_RS17085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HM991_RS17090	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HM991_RS17095	COG0356	it plays a direct role in the translocation of protons across the membrane
HM991_RS17120	COG1131	(ABC) transporter
HM991_RS17150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HM991_RS17165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HM991_RS17180	COG0151	Belongs to the GarS family
HM991_RS17190	COG1215	transferase activity, transferring glycosyl groups
HM991_RS17240	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HM991_RS17275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HM991_RS17285	COG0791	NLP P60 protein
HM991_RS17285	COG1388	LysM domain
HM991_RS17290	COG0126	phosphoglycerate kinase activity
HM991_RS17295	COG0470	DNA polymerase III
HM991_RS17315	COG0445	tRNA wobble uridine modification
HM991_RS17320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HM991_RS17330	COG3239	Fatty acid desaturase
HM991_RS17335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HM991_RS17365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HM991_RS17405	COG0393	Putative heavy-metal-binding
HM991_RS17410	COG0557	exoribonuclease II activity
HM991_RS17420	COG3920	Histidine kinase
HM991_RS17425	COG4565	transcriptional regulatory protein
HM991_RS17430	COG0698	ribose 5-phosphate isomerase
HM991_RS17435	COG1230	cation diffusion facilitator family transporter
HM991_RS17440	COG2153	protein acetylation
HM991_RS17450	COG0793	Belongs to the peptidase S41A family
HM991_RS17455	COG0594	ribonuclease P activity
HM991_RS17470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HM991_RS17480	COG3263	regulation of cellular component size
HM991_RS17485	COG0481	GTPase activity
HM991_RS17500	COG2234	aminopeptidase activity
HM991_RS17515	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HM991_RS17520	COG0346	lactoylglutathione lyase activity
HM991_RS17540	COG0069	glutamate synthase activity
HM991_RS17560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HM991_RS17565	COG1904	glucuronate isomerase
HM991_RS17570	COG1312	Catalyzes the dehydration of D-mannonate
HM991_RS17575	COG1028	Short-chain dehydrogenase reductase Sdr
HM991_RS17580	COG1609	Transcriptional regulator
HM991_RS17600	COG3292	Two component regulator propeller
HM991_RS17600	COG2205	protein histidine kinase activity
HM991_RS17600	COG0745	RESPONSE REGULATOR receiver
HM991_RS17605	COG1629	transport
HM991_RS17615	COG3250	beta-galactosidase activity
HM991_RS17620	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HM991_RS17620	COG5297	Belongs to the glycosyl hydrolase family 6
HM991_RS17630	COG2814	Major facilitator Superfamily
HM991_RS17630	COG0477	Major facilitator Superfamily
HM991_RS17670	COG0307	riboflavin synthase, alpha
HM991_RS17675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HM991_RS17685	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HM991_RS17690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HM991_RS17695	COG0511	ligase activity, forming carbon-carbon bonds
HM991_RS17700	COG0439	Biotin carboxylase
HM991_RS17715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HM991_RS17735	COG0156	8-amino-7-oxononanoate synthase activity
HM991_RS17740	COG2885	chlorophyll binding
HM991_RS17780	COG0720	synthase
HM991_RS17785	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HM991_RS17810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HM991_RS17810	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HM991_RS17830	COG1573	uracil-dna glycosylase
HM991_RS17845	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HM991_RS17860	COG1435	thymidine kinase activity
HM991_RS17865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HM991_RS17870	COG1970	mechanosensitive ion channel activity
HM991_RS17875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HM991_RS17880	COG1505	serine-type exopeptidase activity
HM991_RS17895	COG3842	ATPase activity
HM991_RS17905	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HM991_RS17930	COG3541	Predicted nucleotidyltransferase
HM991_RS17970	COG0328	RNA-DNA hybrid ribonuclease activity
HM991_RS17970	COG3341	Caulimovirus viroplasmin
HM991_RS17975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HM991_RS17980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HM991_RS17985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HM991_RS17990	COG0571	ribonuclease III activity
HM991_RS18000	COG0469	pyruvate kinase activity
HM991_RS18005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HM991_RS18010	COG2954	triphosphatase activity
HM991_RS18035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HM991_RS18040	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HM991_RS18060	COG2151	metal-sulfur cluster biosynthetic enzyme
HM991_RS18065	COG2166	iron-sulfur cluster assembly
HM991_RS18075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HM991_RS18080	COG1695	Transcriptional regulator
HM991_RS18090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HM991_RS18095	COG0719	Fe-S assembly protein
HM991_RS18100	COG0396	ATPase activity
HM991_RS18115	COG0719	Fe-S assembly protein
HM991_RS18120	COG0316	Belongs to the HesB IscA family
HM991_RS18130	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HM991_RS18155	COG1114	Component of the transport system for branched-chain amino acids
HM991_RS18165	COG0697	spore germination
HM991_RS18170	COG0006	proline dipeptidase activity
HM991_RS18185	COG1053	succinate dehydrogenase
HM991_RS18190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HM991_RS18195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HM991_RS18200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HM991_RS18205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HM991_RS18210	COG0612	Peptidase, M16
HM991_RS18215	COG0612	Peptidase, M16
HM991_RS18255	COG4953	penicillin-binding protein 1C
HM991_RS18345	COG1012	belongs to the aldehyde dehydrogenase family
HM991_RS18385	COG4221	oxidoreductase activity
HM991_RS18390	COG4989	oxidoreductase activity
HM991_RS18400	COG0714	Associated with various cellular activities
HM991_RS18415	COG2304	oxidoreductase activity
HM991_RS18455	COG0288	reversible hydration of carbon dioxide
HM991_RS18475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HM991_RS18485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HM991_RS18500	COG1309	transcriptional regulator
HM991_RS18510	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HM991_RS18535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HM991_RS18545	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HM991_RS18555	COG0527	aspartate kinase activity
HM991_RS18590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HM991_RS18595	COG2239	Acts as a magnesium transporter
HM991_RS18600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HM991_RS18615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HM991_RS18625	COG0196	riboflavin kinase activity
HM991_RS18630	COG0193	aminoacyl-tRNA hydrolase activity
HM991_RS18650	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HM991_RS18660	COG3483	tryptophan 2,3-dioxygenase activity
HM991_RS18670	COG0166	Belongs to the GPI family
HM991_RS18675	COG4771	TonB-dependent receptor
HM991_RS18705	COG0776	regulation of translation
HM991_RS18710	COG1530	ribonuclease E activity
HM991_RS18735	COG0495	leucyl-tRNA aminoacylation
HM991_RS18745	COG2177	Part of the ABC transporter FtsEX involved in
HM991_RS18760	COG1968	undecaprenyl-diphosphatase activity
HM991_RS18765	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HM991_RS18780	COG0519	Catalyzes the synthesis of GMP from XMP
HM991_RS18785	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HM991_RS18795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HM991_RS18800	COG3852	Histidine kinase
HM991_RS18810	COG0537	adenosine 5'-monophosphoramidase activity
HM991_RS18815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HM991_RS18830	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HM991_RS18855	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HM991_RS18865	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HM991_RS18875	COG4717	serine-type aminopeptidase activity
HM991_RS18880	COG0436	Aminotransferase
HM991_RS18900	COG1040	competence protein
HM991_RS18910	COG0423	glycine-tRNA ligase activity
HM991_RS18930	COG2072	flavoprotein involved in K transport
HM991_RS18940	COG0708	Exodeoxyribonuclease III
HM991_RS18945	COG1360	Flagellar Motor Protein
HM991_RS18950	COG0667	Aldo Keto reductase
HM991_RS18955	COG1522	sequence-specific DNA binding
HM991_RS18970	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HM991_RS18985	COG0463	Glycosyl transferase, family 2
HM991_RS18990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HM991_RS19000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HM991_RS19005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HM991_RS19020	COG0745	RESPONSE REGULATOR receiver
HM991_RS19025	COG5002	protein histidine kinase activity
HM991_RS19030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HM991_RS19035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HM991_RS19055	COG0489	protein tyrosine kinase activity
HM991_RS19060	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HM991_RS19065	COG0492	ferredoxin-NADP+ reductase activity
HM991_RS19070	COG0633	Ferredoxin
HM991_RS19110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HM991_RS19115	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HM991_RS19120	COG0228	four-way junction DNA binding
HM991_RS19150	COG1028	Short-chain dehydrogenase reductase Sdr
HM991_RS19160	COG0596	Alpha beta hydrolase
HM991_RS19240	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HM991_RS19250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HM991_RS19330	COG2315	Protein conserved in bacteria
HM991_RS19335	COG0784	Response regulator, receiver
HM991_RS19345	COG4251	negative regulation of phosphorylation
HM991_RS19355	COG4251	negative regulation of phosphorylation
HM991_RS19365	COG3279	Response regulator of the LytR AlgR family