locus-tag	class	description
WBP_RS00005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WBP_RS00010	COG0436	Aminotransferase
WBP_RS00030	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WBP_RS00075	COG0477	Major facilitator Superfamily
WBP_RS00080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WBP_RS00090	COG4133	protoheme IX ABC transporter activity
WBP_RS00100	COG0772	Belongs to the SEDS family
WBP_RS00105	COG0651	ATP synthesis coupled electron transport
WBP_RS00130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WBP_RS00145	COG1104	cysteine desulfurase activity
WBP_RS00150	COG2945	thiolester hydrolase activity
WBP_RS00165	COG0316	Belongs to the HesB IscA family
WBP_RS00170	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WBP_RS00175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WBP_RS00175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WBP_RS00185	COG1104	cysteine desulfurase activity
WBP_RS00210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WBP_RS00240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WBP_RS00250	COG1178	ABC-type Fe3 transport system permease component
WBP_RS00260	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WBP_RS00265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WBP_RS00280	COG1113	amino acid transport
WBP_RS00285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WBP_RS00300	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WBP_RS00310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WBP_RS00335	COG0275	rRNA processing
WBP_RS00375	COG1830	Aldolase
WBP_RS00395	COG0167	dihydroorotate dehydrogenase activity
WBP_RS00400	COG0571	ribonuclease III activity
WBP_RS00415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WBP_RS00430	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WBP_RS00435	COG0343	queuine tRNA-ribosyltransferase activity
WBP_RS00440	COG0651	ATP synthesis coupled electron transport
WBP_RS00475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WBP_RS00490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WBP_RS00500	COG1160	GTP binding
WBP_RS00510	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
WBP_RS00515	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WBP_RS00535	COG0194	GDP metabolic process
WBP_RS00550	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WBP_RS00565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WBP_RS00585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WBP_RS00590	COG1181	Belongs to the D-alanine--D-alanine ligase family
WBP_RS00600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WBP_RS00615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WBP_RS00620	COG0450	alkyl hydroperoxide reductase
WBP_RS00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WBP_RS00665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WBP_RS00685	COG0544	peptidyl-prolyl cis-trans isomerase activity
WBP_RS00690	COG0740	serine-type endopeptidase activity
WBP_RS00695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WBP_RS00700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WBP_RS00710	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WBP_RS00715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WBP_RS00770	COG1999	signal sequence binding
WBP_RS00775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WBP_RS00785	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WBP_RS00795	COG0506	proline dehydrogenase activity
WBP_RS00795	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WBP_RS00795	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WBP_RS00820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WBP_RS00830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WBP_RS00845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WBP_RS00850	COG0142	geranyltranstransferase activity
WBP_RS00855	COG0228	four-way junction DNA binding
WBP_RS00870	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WBP_RS00920	COG0045	succinate-CoA ligase (ADP-forming) activity
WBP_RS00930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WBP_RS00940	COG1268	BioY protein
WBP_RS00970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WBP_RS01000	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WBP_RS01020	COG0114	fumarate hydratase activity
WBP_RS01040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WBP_RS01045	COG0359	binds to the 23S rRNA
WBP_RS01050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WBP_RS01055	COG0360	Binds together with S18 to 16S ribosomal RNA
WBP_RS01070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WBP_RS01075	COG1530	ribonuclease E activity
WBP_RS01080	COG0443	Heat shock 70 kDa protein
WBP_RS01085	COG0271	Belongs to the BolA IbaG family
WBP_RS01090	COG0626	cystathionine gamma-synthase activity
WBP_RS01105	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WBP_RS01110	COG0670	Belongs to the BI1 family
WBP_RS01115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WBP_RS01135	COG2009	succinate dehydrogenase
WBP_RS01140	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WBP_RS01170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WBP_RS01195	COG1295	ribonuclease BN
WBP_RS01200	COG1028	Short-chain dehydrogenase reductase Sdr
WBP_RS01215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WBP_RS01225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WBP_RS01230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WBP_RS01235	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WBP_RS01240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WBP_RS01280	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WBP_RS01290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WBP_RS01295	COG0072	phenylalanine-tRNA ligase activity
WBP_RS01295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WBP_RS01305	COG0356	it plays a direct role in the translocation of protons across the membrane
WBP_RS01310	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WBP_RS01330	COG1612	heme a metabolic process
WBP_RS01335	COG4770	biotin carboxylase activity
WBP_RS01345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WBP_RS01365	COG2171	N-acyltransferase activity
WBP_RS01375	COG1053	succinate dehydrogenase
WBP_RS01385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WBP_RS01395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WBP_RS01410	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WBP_RS01410	COG0519	Catalyzes the synthesis of GMP from XMP
WBP_RS01415	COG0861	Integral membrane protein TerC family
WBP_RS01425	COG0527	aspartate kinase activity
WBP_RS01450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WBP_RS01475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WBP_RS01480	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WBP_RS01505	COG0101	tRNA pseudouridine synthase activity
WBP_RS01510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WBP_RS01515	COG0688	phosphatidylethanolamine metabolic process
WBP_RS01520	COG1183	phosphatidylcholine synthase activity
WBP_RS01530	COG1115	amino acid carrier protein
WBP_RS01535	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WBP_RS01545	COG1863	multisubunit Na H antiporter MnhE subunit
WBP_RS01555	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WBP_RS01575	COG0612	Peptidase, M16
WBP_RS01580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WBP_RS01585	COG0196	riboflavin kinase activity
WBP_RS01610	COG0124	histidyl-tRNA synthetase
WBP_RS01615	COG0138	bifunctional purine biosynthesis protein purh
WBP_RS01625	COG1132	(ABC) transporter
WBP_RS01635	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WBP_RS01635	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WBP_RS01640	COG0149	triose-phosphate isomerase activity
WBP_RS01645	COG0567	Dehydrogenase, E1 component
WBP_RS01655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WBP_RS01660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WBP_RS01665	COG1840	ABC-type Fe3 transport system, periplasmic component
WBP_RS01675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WBP_RS01680	COG0254	rRNA binding
WBP_RS01685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WBP_RS01690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WBP_RS01735	COG0723	plastoquinol--plastocyanin reductase activity
WBP_RS01740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WBP_RS01755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WBP_RS01760	COG1006	Multisubunit Na H antiporter MnhC subunit
WBP_RS01785	COG1758	RNA polymerase activity
WBP_RS01795	COG0540	Belongs to the ATCase OTCase family
WBP_RS01810	COG1230	cation diffusion facilitator family transporter
WBP_RS01840	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WBP_RS01860	COG1034	ATP synthesis coupled electron transport
WBP_RS01865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WBP_RS01875	COG0113	porphobilinogen synthase activity
WBP_RS01890	COG0322	excinuclease ABC activity
WBP_RS01895	COG0751	glycine-tRNA ligase activity
WBP_RS01900	COG0752	glycyl-tRNA synthetase alpha subunit
WBP_RS01915	COG0473	3-isopropylmalate dehydrogenase activity
WBP_RS01930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WBP_RS01935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WBP_RS01940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WBP_RS01950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WBP_RS01965	COG2814	Major facilitator Superfamily
WBP_RS01970	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WBP_RS01975	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WBP_RS01980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WBP_RS01985	COG0756	dUTP diphosphatase activity
WBP_RS02020	COG0459	protein refolding
WBP_RS02025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WBP_RS02030	COG0354	folic acid binding
WBP_RS02060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WBP_RS02065	COG0049	tRNA binding
WBP_RS02070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WBP_RS02075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WBP_RS02085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WBP_RS02090	COG0088	Forms part of the polypeptide exit tunnel
WBP_RS02100	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WBP_RS02105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WBP_RS02110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WBP_RS02115	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WBP_RS02120	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WBP_RS02130	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WBP_RS02135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WBP_RS02140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WBP_RS02145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WBP_RS02150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WBP_RS02155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WBP_RS02160	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WBP_RS02165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WBP_RS02170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WBP_RS02175	COG0200	Binds to the 23S rRNA
WBP_RS02180	COG0201	protein transport
WBP_RS02185	COG0563	adenylate kinase activity
WBP_RS02190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WBP_RS02195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WBP_RS02200	COG0202	RNA polymerase activity
WBP_RS02205	COG0203	ribosomal protein L17
WBP_RS02215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WBP_RS02220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WBP_RS02225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WBP_RS02255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WBP_RS02260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WBP_RS02265	COG0109	protoheme IX farnesyltransferase activity
WBP_RS02285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WBP_RS02290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WBP_RS02305	COG1132	(ABC) transporter
WBP_RS02310	COG0018	arginyl-trna synthetase
WBP_RS02320	COG0564	pseudouridine synthase activity
WBP_RS02325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WBP_RS02335	COG0574	Belongs to the PEP-utilizing enzyme family
WBP_RS02335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WBP_RS02350	COG1494	fructose-1,6-bisphosphatase
WBP_RS02355	COG0012	GTP binding
WBP_RS02360	COG0617	tRNA 3'-terminal CCA addition
WBP_RS02395	COG0477	Major facilitator Superfamily
WBP_RS02405	COG0590	tRNA wobble adenosine to inosine editing
WBP_RS02410	COG0504	CTP synthase activity
WBP_RS02425	COG1074	ATP-dependent DNA helicase activity
WBP_RS02430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WBP_RS02440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WBP_RS02460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WBP_RS02470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WBP_RS02480	COG0542	response to heat
WBP_RS02485	COG2902	Dehydrogenase
WBP_RS02510	COG0805	protein transport
WBP_RS02525	COG0305	Participates in initiation and elongation during chromosome replication
WBP_RS02535	COG1714	RDD family
WBP_RS02555	COG2814	Major facilitator Superfamily
WBP_RS02580	COG1115	amino acid carrier protein
WBP_RS02590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WBP_RS02600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WBP_RS02605	COG0358	DNA primase activity
WBP_RS02615	COG0424	maF-like protein
WBP_RS02620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WBP_RS02630	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WBP_RS02660	COG2239	Acts as a magnesium transporter
WBP_RS02675	COG0717	Belongs to the dCTP deaminase family
WBP_RS02690	COG1686	Belongs to the peptidase S11 family
WBP_RS02715	COG1138	Cytochrome C-type biogenesis protein
WBP_RS02720	COG2890	protein-(glutamine-N5) methyltransferase activity
WBP_RS02720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WBP_RS02735	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WBP_RS02750	COG3736	Type IV secretory pathway, component VirB8
WBP_RS02770	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WBP_RS02775	COG0174	glutamine synthetase
WBP_RS02790	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WBP_RS02795	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
WBP_RS02800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WBP_RS02825	COG0653	protein targeting
WBP_RS02865	COG0237	dephospho-CoA kinase activity
WBP_RS02870	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WBP_RS02875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WBP_RS02890	COG0493	'glutamate synthase
WBP_RS02890	COG0543	2 iron, 2 sulfur cluster binding
WBP_RS02895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WBP_RS02900	COG2094	Belongs to the DNA glycosylase MPG family
WBP_RS02910	COG2255	four-way junction helicase activity
WBP_RS02915	COG0632	four-way junction helicase activity
WBP_RS02940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WBP_RS02950	COG0494	nUDIX hydrolase
WBP_RS02955	COG0084	hydrolase, TatD family'
WBP_RS02960	COG0039	L-malate dehydrogenase activity
WBP_RS02965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WBP_RS02970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WBP_RS02975	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WBP_RS03005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WBP_RS03010	COG0321	lipoyl(octanoyl) transferase activity
WBP_RS03020	COG0047	phosphoribosylformylglycinamidine synthase activity
WBP_RS03025	COG0581	inorganic phosphate transmembrane transporter activity
WBP_RS03035	COG0335	large ribosomal subunit rRNA binding
WBP_RS03040	COG0336	Belongs to the RNA methyltransferase TrmD family
WBP_RS03045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WBP_RS03050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WBP_RS03080	COG0612	Peptidase, M16
WBP_RS03085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WBP_RS03100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WBP_RS03140	COG0629	single-stranded DNA binding
WBP_RS03145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WBP_RS03155	COG0482	sulfurtransferase activity
WBP_RS03170	COG2885	chlorophyll binding
WBP_RS03175	COG0037	tRNA processing
WBP_RS03180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WBP_RS03195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WBP_RS03235	COG0326	Molecular chaperone. Has ATPase activity
WBP_RS03280	COG0156	8-amino-7-oxononanoate synthase activity
WBP_RS03290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WBP_RS03295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WBP_RS03300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WBP_RS03305	COG2205	protein histidine kinase activity
WBP_RS03310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WBP_RS03315	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WBP_RS03340	COG0745	RESPONSE REGULATOR receiver
WBP_RS03345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WBP_RS03350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WBP_RS03365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WBP_RS03370	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WBP_RS03395	COG0606	chelatase, subunit chli
WBP_RS03420	COG0495	leucyl-tRNA aminoacylation
WBP_RS03480	COG0445	tRNA wobble uridine modification
WBP_RS03485	COG0006	proline dipeptidase activity
WBP_RS03495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WBP_RS03500	COG0416	fatty acid biosynthetic process
WBP_RS03505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WBP_RS03510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WBP_RS03515	COG4175	Glycine betaine
WBP_RS03520	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WBP_RS03530	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WBP_RS03530	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WBP_RS03535	COG1007	ATP synthesis coupled electron transport
WBP_RS03540	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WBP_RS03545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WBP_RS03550	COG0713	ATP synthesis coupled electron transport
WBP_RS03595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WBP_RS03600	COG3485	protocatechuate 3,4-dioxygenase
WBP_RS03605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WBP_RS03610	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WBP_RS03615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WBP_RS03635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WBP_RS03650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WBP_RS03660	COG0009	L-threonylcarbamoyladenylate synthase
WBP_RS03680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WBP_RS03685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WBP_RS03690	COG1674	ftsk spoiiie
WBP_RS03710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WBP_RS03710	COG0085	RNA polymerase activity
WBP_RS03715	COG0222	ribosome binding
WBP_RS03720	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WBP_RS03725	COG0081	regulation of translation
WBP_RS03730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WBP_RS03735	COG0250	Participates in transcription elongation, termination and antitermination
WBP_RS03750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WBP_RS03765	COG0505	Belongs to the CarA family
WBP_RS03780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WBP_RS03785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WBP_RS03825	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WBP_RS03830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WBP_RS03845	COG0508	dehydrogenase complex catalyzes the overall conversion of
WBP_RS03845	COG0022	dehydrogenase e1 component
WBP_RS03855	COG0481	GTPase activity
WBP_RS03895	COG0217	transcriptional regulatory protein
WBP_RS03910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WBP_RS03915	COG0280	phosphate acetyltransferase
WBP_RS03915	COG0281	malic enzyme
WBP_RS03940	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WBP_RS03945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WBP_RS03950	COG3932	Exopolysaccharide synthesis, ExoD
WBP_RS03955	COG0215	cysteine-tRNA ligase activity
WBP_RS03975	COG0126	phosphoglycerate kinase activity
WBP_RS03980	COG0492	ferredoxin-NADP+ reductase activity
WBP_RS03985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WBP_RS03990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WBP_RS03995	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WBP_RS04000	COG0573	inorganic phosphate transmembrane transporter activity
WBP_RS04005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WBP_RS04030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WBP_RS04035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WBP_RS04035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WBP_RS04040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WBP_RS04045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WBP_RS04050	COG1845	cytochrome c oxidase, subunit III
WBP_RS04065	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WBP_RS04075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WBP_RS04080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WBP_RS04135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WBP_RS04140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WBP_RS04145	COG0312	modulator of DNA gyrase
WBP_RS04150	COG1278	Cold shock
WBP_RS04155	COG0513	Belongs to the DEAD box helicase family
WBP_RS04205	COG1322	Protein conserved in bacteria
WBP_RS04235	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WBP_RS04240	COG1121	(ABC) transporter
WBP_RS04250	COG0105	UTP biosynthetic process
WBP_RS04260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WBP_RS04280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WBP_RS04285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WBP_RS04285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WBP_RS04295	COG0312	modulator of DNA gyrase
WBP_RS04330	COG0628	permease
WBP_RS04335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WBP_RS04340	COG4974	Belongs to the 'phage' integrase family
WBP_RS04350	COG0268	Binds directly to 16S ribosomal RNA
WBP_RS04355	COG0372	Belongs to the citrate synthase family
WBP_RS04370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WBP_RS04375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WBP_RS04380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WBP_RS04385	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
WBP_RS04420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WBP_RS04440	COG0508	dehydrogenase complex catalyzes the overall conversion of
WBP_RS04460	COG3451	type IV secretory pathway VirB4
WBP_RS04475	COG2070	2-Nitropropane dioxygenase
WBP_RS04490	COG0552	protein localization to endoplasmic reticulum
WBP_RS04495	COG0822	iron-sulfur transferase activity
WBP_RS04500	COG0316	Belongs to the HesB IscA family
WBP_RS04510	COG0443	Heat shock 70 kDa protein
WBP_RS04515	COG0681	Belongs to the peptidase S26 family
WBP_RS04525	COG0154	amidase activity
WBP_RS04530	COG0187	DNA topoisomerase II activity
WBP_RS04550	COG0539	negative regulation of cytoplasmic translation
WBP_RS04555	COG0776	regulation of translation
WBP_RS04570	COG0750	zinc metalloprotease
WBP_RS04585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WBP_RS04590	COG0543	2 iron, 2 sulfur cluster binding
WBP_RS04590	COG0493	'glutamate synthase
WBP_RS04600	COG0508	dehydrogenase complex catalyzes the overall conversion of
WBP_RS04615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WBP_RS04635	COG0849	cell division
WBP_RS04640	COG0242	peptide deformylase activity
WBP_RS04645	COG1573	uracil-dna glycosylase
WBP_RS04655	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WBP_RS04660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WBP_RS04665	COG0148	phosphopyruvate hydratase activity
WBP_RS04670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WBP_RS04680	COG0728	peptidoglycan biosynthetic process
WBP_RS04695	COG3474	cytochrome
WBP_RS04700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WBP_RS04705	COG0649	NAD binding
WBP_RS04725	COG0193	aminoacyl-tRNA hydrolase activity
WBP_RS04730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WBP_RS04755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WBP_RS04760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WBP_RS04770	COG0307	riboflavin synthase, alpha
WBP_RS04790	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WBP_RS04795	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WBP_RS04800	COG0736	holo-[acyl-carrier-protein] synthase activity
WBP_RS04805	COG0442	prolyl-tRNA aminoacylation
WBP_RS04825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WBP_RS04830	COG0163	prenyltransferase activity
WBP_RS04835	COG3750	Belongs to the UPF0335 family
WBP_RS04840	COG4536	flavin adenine dinucleotide binding
WBP_RS04885	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WBP_RS04885	COG0116	Belongs to the methyltransferase superfamily
WBP_RS04895	COG0419	ATPase involved in DNA repair
WBP_RS04895	COG3704	protein secretion by the type IV secretion system
WBP_RS04900	COG3704	protein secretion by the type IV secretion system
WBP_RS04905	COG3704	protein secretion by the type IV secretion system
WBP_RS04910	COG3704	protein secretion by the type IV secretion system
WBP_RS04915	COG3451	type IV secretory pathway VirB4
WBP_RS04925	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WBP_RS04960	COG0330	HflC and HflK could
WBP_RS04985	COG0556	nucleotide-excision repair
WBP_RS04990	COG2857	Cytochrome c1
WBP_RS04990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WBP_RS04995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WBP_RS05030	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WBP_RS05065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WBP_RS05090	COG0484	heat shock protein binding
WBP_RS05095	COG0525	valine-tRNA ligase activity
WBP_RS05105	COG0284	orotidine-5'-phosphate decarboxylase activity
WBP_RS05115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WBP_RS05130	COG1301	dicarboxylic acid transport
WBP_RS05135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WBP_RS05145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WBP_RS05150	COG0489	protein tyrosine kinase activity
WBP_RS05180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WBP_RS05190	COG0575	Belongs to the CDS family
WBP_RS05195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WBP_RS05205	COG0233	cytoplasmic translational termination
WBP_RS05210	COG0528	UMP kinase activity
WBP_RS05215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WBP_RS05220	COG0052	Belongs to the universal ribosomal protein uS2 family
WBP_RS05240	COG1253	flavin adenine dinucleotide binding