locus-tag	class	description
HF196_RS00045	ENOG4105HFZ	Membrane
HF196_RS00050	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
HF196_RS00060	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HF196_RS00095	ENOG4105ETU	transcriptional activator (TenA
HF196_RS00100	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HF196_RS00115	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HF196_RS00135	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HF196_RS00160	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
HF196_RS00165	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HF196_RS00170	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HF196_RS00180	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HF196_RS00190	ENOG4108K5P	(LipO)protein
HF196_RS00195	ENOG4105C8T	Leucyl-tRNA synthetase
HF196_RS00220	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HF196_RS00235	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HF196_RS00255	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
HF196_RS00260	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HF196_RS00265	ENOG4108ZAI	phosphatidylglycerophosphatase a
HF196_RS00280	ENOG4105E33	succinate dehydrogenase
HF196_RS00285	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HF196_RS00305	ENOG4105C0P	Mg chelatase subunit ChlI
HF196_RS00315	ENOG4105VQU	rdd domain containing protein
HF196_RS00325	ENOG4105CDU	Replicative dna helicase
HF196_RS00335	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HF196_RS00340	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HF196_RS00345	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HF196_RS00370	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HF196_RS00375	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HF196_RS00395	ENOG4105DHZ	alpha beta
HF196_RS00400	ENOG4107QI6	Cysteine desulfurase
HF196_RS00415	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HF196_RS00430	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HF196_RS00440	ENOG4105G9V	cytochrome C
HF196_RS00450	ENOG4107SVN	transposase
HF196_RS00480	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HF196_RS00495	ENOG4105KWW	Biogenesis protein
HF196_RS00540	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HF196_RS00545	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HF196_RS00555	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HF196_RS00560	ENOG41082FS	50S ribosomal protein L31
HF196_RS00565	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HF196_RS00575	ENOG4105CW7	secretion protein, HlyD family
HF196_RS00590	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HF196_RS00615	ENOG4108VX5	3-methyladenine DNA glycosylase
HF196_RS00630	ENOG4105DTN	riboflavin biosynthesis protein ribF
HF196_RS00635	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HF196_RS00655	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HF196_RS00665	ENOG4105SC1	monovalent cation H antiporter subunit E
HF196_RS00670	ENOG4105EE5	Membrane protein terC
HF196_RS00675	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HF196_RS00700	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HF196_RS00705	ENOG4105CN1	protease
HF196_RS00725	ENOG4105EIE	fructose-bisphosphate aldolase
HF196_RS00735	ENOG4105EA8	2-Nitropropane dioxygenase
HF196_RS00745	ENOG4105C1V	Peptidase, M16
HF196_RS00775	ENOG41072GX	Peptidase M22 Glycoprotease
HF196_RS00785	ENOG4105MP9	class II Aldolase
HF196_RS00790	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HF196_RS00820	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HF196_RS00835	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
HF196_RS00850	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HF196_RS00855	ENOG4105D5Q	Arginine ornithine antiporter
HF196_RS00875	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HF196_RS00885	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
HF196_RS00890	ENOG4105C72	UPF0176 protein
HF196_RS00900	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HF196_RS00910	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HF196_RS00920	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HF196_RS00935	ENOG4105CAS	nag kinase
HF196_RS00940	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HF196_RS00945	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HF196_RS00955	ENOG4105C2C	drug resistance transporter, Bcr CflA
HF196_RS01005	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HF196_RS01015	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HF196_RS01020	ENOG4105DZP	Membrane-associated zinc metalloprotease
HF196_RS01035	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HF196_RS01040	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HF196_RS01045	ENOG41060IM	Heme exporter protein
HF196_RS01070	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HF196_RS01080	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HF196_RS01100	ENOG4108UQY	Iron-storage protein
HF196_RS01110	ENOG4105N82	Endonuclease
HF196_RS01115	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HF196_RS01150	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HF196_RS01155	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HF196_RS01170	ENOG4107QIZ	NADH dehydrogenase
HF196_RS01225	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HF196_RS01245	ENOG4108QTG	type IV secretion system protein
HF196_RS01250	ENOG4106Q4M	protein secretion by the type IV secretion system
HF196_RS01285	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HF196_RS01295	ENOG4105C3J	Cysteine desulfurase
HF196_RS01300	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HF196_RS01310	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HF196_RS01320	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HF196_RS01325	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HF196_RS01330	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HF196_RS01355	ENOG4107RCQ	(CBS) domain
HF196_RS01370	ENOG4105KPY	Small multidrug resistance protein
HF196_RS01385	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HF196_RS01390	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HF196_RS01395	ENOG4105VC4	domain protein
HF196_RS01415	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HF196_RS01435	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HF196_RS01440	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HF196_RS01445	ENOG4105C3F	Signal peptidase i
HF196_RS01450	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HF196_RS01480	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HF196_RS01495	ENOG4105PGM	cation diffusion facilitator family transporter
HF196_RS01500	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HF196_RS01505	ENOG4105BZG	amino acid carrier protein
HF196_RS01510	ENOG4105BZG	amino acid carrier protein
HF196_RS01515	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HF196_RS01520	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
HF196_RS01525	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HF196_RS01530	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HF196_RS01540	ENOG4105CJN	penicillin-binding protein
HF196_RS01560	ENOG4105Y2X	UPF0335 protein
HF196_RS01565	ENOG4108JU6	CBS domain protein
HF196_RS01570	ENOG4105C8Y	Acetylornithine aminotransferase
HF196_RS01580	ENOG4105CP7	Triose-phosphate isomerase
HF196_RS01585	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HF196_RS01590	ENOG4105BZ1	(ABC) transporter
HF196_RS01595	ENOG4108KAG	Cytochrome C oxidase, subunit I
HF196_RS01630	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
HF196_RS01640	ENOG4105CY3	ABC transporter, permease
HF196_RS01645	ENOG4105DHJ	ABC, transporter
HF196_RS01650	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HF196_RS01655	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HF196_RS01665	ENOG4105C1J	atp-dependent rna helicase
HF196_RS01685	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HF196_RS01710	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HF196_RS01750	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HF196_RS01765	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HF196_RS01780	ENOG4108Z1B	Cyclase dehydrase
HF196_RS01810	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HF196_RS01815	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HF196_RS01835	ENOG4105CUT	histidyl-tRNA synthetase
HF196_RS01845	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HF196_RS01850	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HF196_RS01855	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HF196_RS01905	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF196_RS01925	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
HF196_RS01940	ENOG4105CNU	cell division protein FtsK
HF196_RS01945	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HF196_RS01950	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HF196_RS01955	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HF196_RS01960	ENOG4105E2Z	phosphate ABC transporter (Permease
HF196_RS01970	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HF196_RS01975	ENOG4107QPR	SAICAR synthetase
HF196_RS01980	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HF196_RS01985	ENOG4105CSM	endonuclease III
HF196_RS01995	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HF196_RS02020	ENOG4105CZQ	inner membrane transport protein YdhC
HF196_RS02035	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HF196_RS02040	ENOG4105CNI	cell division protein FtsW
HF196_RS02065	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HF196_RS02080	ENOG4105C0D	helicase
HF196_RS02095	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF196_RS02110	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF196_RS02115	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HF196_RS02125	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HF196_RS02135	ENOG4105VIE	preprotein translocase, subunit YajC
HF196_RS02140	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HF196_RS02155	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HF196_RS02185	ENOG4105CB5	ATP-dependent DNA helicase recG
HF196_RS02195	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HF196_RS02205	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HF196_RS02235	ENOG4105C8Y	Acetylornithine aminotransferase
HF196_RS02240	ENOG4105BZU	Histidine kinase
HF196_RS02245	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HF196_RS02250	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HF196_RS02260	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HF196_RS02270	ENOG41067UH	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HF196_RS02300	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HF196_RS02310	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HF196_RS02325	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HF196_RS02335	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HF196_RS02345	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HF196_RS02360	ENOG4105C9M	aspartyl-trna synthetase
HF196_RS02365	ENOG4105CSH	Transporter
HF196_RS02375	ENOG4105C22	threonyL-tRNA synthetase
HF196_RS02385	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF196_RS02390	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HF196_RS02410	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HF196_RS02420	ENOG4108I0Z	Aconitate hydratase
HF196_RS02430	ENOG4105EFC	phage portal protein HK97 family
HF196_RS02480	ENOG4107R3N	Filamentation induced by cAMP protein fic
HF196_RS02520	ENOG4105CPQ	Dehydrogenase
HF196_RS02535	ENOG4105K63	Thioredoxin
HF196_RS02565	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HF196_RS02590	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HF196_RS02595	ENOG4105D52	delta-aminolevulinic acid dehydratase
HF196_RS02640	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HF196_RS02655	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HF196_RS02670	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HF196_RS02675	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HF196_RS02680	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HF196_RS02685	ENOG4108VZM	50s ribosomal protein L10
HF196_RS02695	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HF196_RS02715	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HF196_RS02745	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HF196_RS02755	ENOG4107QX3	carboxylase
HF196_RS02780	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HF196_RS02785	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HF196_RS02790	ENOG4105VGS	50s ribosomal protein l32
HF196_RS02800	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HF196_RS02810	ENOG4105DC7	peptidase M24
HF196_RS02825	ENOG4108Z4V	iron-sulfur cluster assembly
HF196_RS02830	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HF196_RS02840	ENOG4105CFH	Aspartokinase
HF196_RS02875	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HF196_RS02880	ENOG4105F8V	Hydrolase, tatD family
HF196_RS02890	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HF196_RS02895	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF196_RS02900	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HF196_RS02905	ENOG4105K59	histidine triad (HIT) protein
HF196_RS02920	ENOG4105ECP	epimerase
HF196_RS02930	ENOG4105DJV	ribulose-phosphate 3-epimerase
HF196_RS02940	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HF196_RS02960	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HF196_RS02980	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HF196_RS02990	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HF196_RS02995	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HF196_RS03000	ENOG4105CTB	Polyprenyl synthetase
HF196_RS03010	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HF196_RS03030	ENOG4105BZS	acriflavin resistance protein
HF196_RS03040	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HF196_RS03045	ENOG4108AGE	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HF196_RS03070	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HF196_RS03080	ENOG4105DFU	Cell wall formation (By similarity)
HF196_RS03085	ENOG4105K6T	rare lipoprotein A
HF196_RS03155	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HF196_RS03170	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HF196_RS03175	ENOG4105EAH	synthase
HF196_RS03195	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HF196_RS03200	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HF196_RS03210	ENOG4108R6K	riboflavin synthase, subunit alpha
HF196_RS03230	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HF196_RS03250	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HF196_RS03255	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HF196_RS03265	ENOG4105C7S	Dehydrogenase
HF196_RS03280	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HF196_RS03300	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
HF196_RS03305	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HF196_RS03310	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HF196_RS03315	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HF196_RS03320	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HF196_RS03350	ENOG4105VG0	50S ribosomal protein l34
HF196_RS03355	ENOG4105C8U	phosphate abc transporter
HF196_RS03360	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HF196_RS03365	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HF196_RS03375	ENOG4105CAY	ferredoxin--nadp reductase
HF196_RS03380	ENOG4105BZA	Phosphoglycerate kinase
HF196_RS03400	ENOG4105C8N	cysteinyl-tRNA synthetase
HF196_RS03415	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HF196_RS03420	ENOG4108IJ6	ABC transporter
HF196_RS03450	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HF196_RS03455	ENOG4108JJ6	Type I secretion system ATPase
HF196_RS03485	ENOG4105DA4	cytochrome c-type biogenesis protein
HF196_RS03495	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HF196_RS03505	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HF196_RS03535	ENOG4105BZG	amino acid carrier protein
HF196_RS03555	ENOG4108EHY	type IV secretion system
HF196_RS03570	ENOG4108V42	Type IV secretion system protein VirB8
HF196_RS03575	ENOG4107QJN	gtp cyclohydrolase ii
HF196_RS03590	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HF196_RS03605	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HF196_RS03650	ENOG4105VKD	bioY protein
HF196_RS03660	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HF196_RS03670	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HF196_RS03690	ENOG4108JDX	DNA polymerase iii, epsilon subunit
HF196_RS03700	ENOG4105BZN	citrate synthase
HF196_RS03715	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HF196_RS03720	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HF196_RS03725	ENOG4105C02	permease
HF196_RS03730	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HF196_RS03765	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HF196_RS03780	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HF196_RS03795	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HF196_RS03845	ENOG4107RIZ	hflk protein
HF196_RS03850	ENOG4105EPW	hflc protein
HF196_RS03890	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HF196_RS03895	ENOG4105FDK	ABC transporter
HF196_RS03920	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HF196_RS03925	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HF196_RS03930	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HF196_RS03945	ENOG4105EEI	dihydropteroate synthase
HF196_RS03955	ENOG4107ZH2	Coenzyme PQQ synthesis protein C
HF196_RS03960	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HF196_RS03965	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HF196_RS03985	ENOG4105CK2	sodium dicarboxylate symporter
HF196_RS03990	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HF196_RS04015	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HF196_RS04050	ENOG4105VN1	Heat shock protein
HF196_RS04100	ENOG4105WVQ	Fe-S assembly protein IscX
HF196_RS04115	ENOG4105KDC	50s ribosomal protein l28
HF196_RS04120	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HF196_RS04130	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HF196_RS04135	ENOG4105C7I	Dehydrogenase
HF196_RS04170	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HF196_RS04180	ENOG4105KNE	Phosphatidate cytidylyltransferase
HF196_RS04185	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HF196_RS04190	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HF196_RS04195	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HF196_RS04200	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HF196_RS04205	ENOG4105CE9	30S ribosomal protein S2
HF196_RS04215	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HF196_RS04220	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HF196_RS04255	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HF196_RS04270	ENOG41082WC	Transport-associated protein
HF196_RS04275	ENOG4105D7Z	glutathione synthase
HF196_RS04280	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HF196_RS04315	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HF196_RS04320	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HF196_RS04325	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HF196_RS04330	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HF196_RS04335	ENOG4108UFP	Essential cell division protein (By similarity)
HF196_RS04340	ENOG4105CPF	Cell wall formation (By similarity)
HF196_RS04345	ENOG4108Z4U	Ferredoxin
HF196_RS04350	ENOG4105C79	DNA protecting protein DprA
HF196_RS04355	ENOG4108MDK	Dehydrogenase
HF196_RS04360	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HF196_RS04365	ENOG4105D3R	alkyl hydroperoxide reductase
HF196_RS04380	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HF196_RS04385	ENOG4107QN2	dihydrolipoyl dehydrogenase
HF196_RS04400	ENOG4105C03	ribonuclease
HF196_RS04405	ENOG4105W0E	50S ribosomal protein L33
HF196_RS04420	ENOG4105C83	adenylosuccinate lyase
HF196_RS04430	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HF196_RS04440	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HF196_RS04455	ENOG4105W5Q	DNA repair protein (RadC
HF196_RS04565	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HF196_RS04580	ENOG4105CSH	Transporter
HF196_RS04590	ENOG4108Z6B	deaminase
HF196_RS04595	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HF196_RS04605	ENOG4105W5Q	DNA repair protein (RadC
HF196_RS04625	ENOG4105D1F	ATP-binding protein
HF196_RS04635	ENOG4105DZ1	carboxypeptidase
HF196_RS04645	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HF196_RS04655	ENOG4105C3G	gtp-binding protein
HF196_RS04665	ENOG4105CBT	Fructose-1,6-bisphosphatase
HF196_RS04695	ENOG4105CPP	Dehydrogenase, E1 component
HF196_RS04700	ENOG4105CJW	magnesium transporter
HF196_RS04720	ENOG4105VN1	Heat shock protein
HF196_RS04730	ENOG4105CI3	gtp-binding protein typa
HF196_RS04735	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HF196_RS04740	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HF196_RS04760	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HF196_RS04765	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HF196_RS04800	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HF196_RS04805	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HF196_RS04810	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HF196_RS04825	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HF196_RS04860	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HF196_RS04870	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HF196_RS04985	ENOG4107SNB	ankyrin repeat protein YahD
HF196_RS05035	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HF196_RS05055	ENOG4105BZ1	(ABC) transporter
HF196_RS05065	ENOG4105C75	arginyL-tRNA synthetase
HF196_RS05085	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HF196_RS05100	ENOG4105FA0	parb-like partition protein
HF196_RS05150	ENOG4105C2C	drug resistance transporter, Bcr CflA
HF196_RS05170	ENOG4108JYK	Dehydrogenase
HF196_RS05175	ENOG4108YXA	Membrane
HF196_RS05185	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HF196_RS05220	ENOG4105FAV	ABC, transporter
HF196_RS05230	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HF196_RS05235	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HF196_RS05250	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HF196_RS05330	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HF196_RS05350	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HF196_RS05355	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HF196_RS05360	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HF196_RS05380	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HF196_RS05385	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HF196_RS05390	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HF196_RS05395	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HF196_RS05400	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HF196_RS05410	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HF196_RS05415	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HF196_RS05420	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HF196_RS05430	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HF196_RS05435	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HF196_RS05440	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HF196_RS05445	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HF196_RS05450	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HF196_RS05455	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HF196_RS05460	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HF196_RS05465	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HF196_RS05475	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HF196_RS05480	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HF196_RS05490	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HF196_RS05520	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HF196_RS05540	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HF196_RS05565	ENOG4107QKV	phosphomannomutase
HF196_RS05575	ENOG4107U9T	Pfam:Ribonuclease_BN
HF196_RS05580	ENOG4105EMU	Dehydrogenase
HF196_RS05605	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HF196_RS05610	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HF196_RS05625	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HF196_RS05695	ENOG4105M2J	Glutaredoxin
HF196_RS05705	ENOG4105C6K	Malic enzyme
HF196_RS05710	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HF196_RS05720	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HF196_RS05760	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HF196_RS05765	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HF196_RS05780	ENOG4105D4A	Cell wall formation (By similarity)