locus-tag	class	description
HF196_RS00015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HF196_RS00020	COG2009	succinate dehydrogenase
HF196_RS00045	COG0670	Belongs to the BI1 family
HF196_RS00050	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HF196_RS00065	COG0626	cystathionine gamma-synthase activity
HF196_RS00085	COG1845	cytochrome c oxidase, subunit III
HF196_RS00095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HF196_RS00100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HF196_RS00115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HF196_RS00135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HF196_RS00160	COG1573	uracil-dna glycosylase
HF196_RS00165	COG0242	peptide deformylase activity
HF196_RS00170	COG0849	cell division
HF196_RS00180	COG1160	GTP binding
HF196_RS00190	COG4942	peptidase
HF196_RS00190	COG1388	LysM domain
HF196_RS00195	COG0495	leucyl-tRNA aminoacylation
HF196_RS00220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HF196_RS00235	COG0343	queuine tRNA-ribosyltransferase activity
HF196_RS00240	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HF196_RS00255	COG0745	RESPONSE REGULATOR receiver
HF196_RS00260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HF196_RS00265	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HF196_RS00280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HF196_RS00285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HF196_RS00305	COG0606	chelatase, subunit chli
HF196_RS00315	COG1714	RDD family
HF196_RS00325	COG0305	Participates in initiation and elongation during chromosome replication
HF196_RS00335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HF196_RS00340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HF196_RS00345	COG0358	DNA primase activity
HF196_RS00370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HF196_RS00370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HF196_RS00375	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HF196_RS00395	COG2945	thiolester hydrolase activity
HF196_RS00400	COG1104	cysteine desulfurase activity
HF196_RS00415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HF196_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HF196_RS00430	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HF196_RS00430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HF196_RS00440	COG3474	cytochrome
HF196_RS00480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HF196_RS00495	COG3088	subunit of a heme lyase
HF196_RS00505	COG0114	fumarate hydratase activity
HF196_RS00540	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HF196_RS00545	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HF196_RS00555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HF196_RS00560	COG0254	rRNA binding
HF196_RS00565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HF196_RS00575	COG1566	PFAM secretion protein HlyD family protein
HF196_RS00590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HF196_RS00615	COG2094	Belongs to the DNA glycosylase MPG family
HF196_RS00630	COG0196	riboflavin kinase activity
HF196_RS00635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HF196_RS00640	COG0612	Peptidase, M16
HF196_RS00655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HF196_RS00665	COG1863	multisubunit Na H antiporter MnhE subunit
HF196_RS00670	COG0861	Integral membrane protein TerC family
HF196_RS00675	COG0519	Catalyzes the synthesis of GMP from XMP
HF196_RS00675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HF196_RS00700	COG0167	dihydroorotate dehydrogenase activity
HF196_RS00705	COG0793	Belongs to the peptidase S41A family
HF196_RS00725	COG1830	Aldolase
HF196_RS00735	COG2070	2-Nitropropane dioxygenase
HF196_RS00745	COG0612	Peptidase, M16
HF196_RS00750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HF196_RS00785	COG0235	Class ii aldolase
HF196_RS00790	COG0321	lipoyl(octanoyl) transferase activity
HF196_RS00820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HF196_RS00835	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HF196_RS00850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HF196_RS00870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HF196_RS00875	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HF196_RS00885	COG1178	ABC-type Fe3 transport system permease component
HF196_RS00900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HF196_RS00910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HF196_RS00920	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HF196_RS00935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HF196_RS00940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HF196_RS00945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HF196_RS00955	COG2814	Major facilitator Superfamily
HF196_RS00985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HF196_RS01000	COG0543	2 iron, 2 sulfur cluster binding
HF196_RS01000	COG0493	'glutamate synthase
HF196_RS01005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HF196_RS01020	COG0750	zinc metalloprotease
HF196_RS01035	COG0776	regulation of translation
HF196_RS01040	COG0539	negative regulation of cytoplasmic translation
HF196_RS01045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HF196_RS01070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HF196_RS01080	COG0326	Molecular chaperone. Has ATPase activity
HF196_RS01110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HF196_RS01115	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HF196_RS01150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HF196_RS01150	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HF196_RS01155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HF196_RS01160	COG1034	ATP synthesis coupled electron transport
HF196_RS01170	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HF196_RS01215	COG0666	response to abiotic stimulus
HF196_RS01225	COG0275	rRNA processing
HF196_RS01245	COG3704	protein secretion by the type IV secretion system
HF196_RS01245	COG1340	protein secretion by the type IV secretion system
HF196_RS01250	COG3704	protein secretion by the type IV secretion system
HF196_RS01255	COG3704	protein secretion by the type IV secretion system
HF196_RS01260	COG3451	type IV secretory pathway VirB4
HF196_RS01270	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HF196_RS01285	COG0101	tRNA pseudouridine synthase activity
HF196_RS01295	COG1104	cysteine desulfurase activity
HF196_RS01310	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HF196_RS01320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HF196_RS01325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HF196_RS01330	COG0723	plastoquinol--plastocyanin reductase activity
HF196_RS01355	COG1253	flavin adenine dinucleotide binding
HF196_RS01365	COG0436	Aminotransferase
HF196_RS01370	COG2076	Multidrug Resistance protein
HF196_RS01385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HF196_RS01390	COG0525	valine-tRNA ligase activity
HF196_RS01395	COG2827	Endonuclease containing a URI domain
HF196_RS01415	COG0009	L-threonylcarbamoyladenylate synthase
HF196_RS01435	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HF196_RS01440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HF196_RS01445	COG0681	Belongs to the peptidase S26 family
HF196_RS01450	COG0484	heat shock protein binding
HF196_RS01480	COG0154	amidase activity
HF196_RS01495	COG1230	cation diffusion facilitator family transporter
HF196_RS01500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HF196_RS01505	COG1115	amino acid carrier protein
HF196_RS01510	COG1115	amino acid carrier protein
HF196_RS01515	COG1183	phosphatidylcholine synthase activity
HF196_RS01520	COG0688	phosphatidylethanolamine metabolic process
HF196_RS01525	COG0736	holo-[acyl-carrier-protein] synthase activity
HF196_RS01530	COG0442	prolyl-tRNA aminoacylation
HF196_RS01540	COG0768	penicillin binding
HF196_RS01560	COG3750	Belongs to the UPF0335 family
HF196_RS01565	COG4536	flavin adenine dinucleotide binding
HF196_RS01570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HF196_RS01580	COG0149	triose-phosphate isomerase activity
HF196_RS01585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HF196_RS01585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HF196_RS01590	COG1132	(ABC) transporter
HF196_RS01595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HF196_RS01605	COG1053	succinate dehydrogenase
HF196_RS01630	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HF196_RS01640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HF196_RS01645	COG1127	ABC transporter
HF196_RS01650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HF196_RS01655	COG0312	modulator of DNA gyrase
HF196_RS01660	COG1278	Cold shock
HF196_RS01665	COG0513	Belongs to the DEAD box helicase family
HF196_RS01685	COG2171	N-acyltransferase activity
HF196_RS01710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HF196_RS01720	COG4770	biotin carboxylase activity
HF196_RS01745	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HF196_RS01750	COG0356	it plays a direct role in the translocation of protons across the membrane
HF196_RS01765	COG0285	dihydrofolate synthase activity
HF196_RS01810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HF196_RS01815	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HF196_RS01835	COG0124	histidyl-tRNA synthetase
HF196_RS01845	COG0484	heat shock protein binding
HF196_RS01850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HF196_RS01870	COG1840	ABC-type Fe3 transport system, periplasmic component
HF196_RS01905	COG0649	NAD binding
HF196_RS01915	COG0564	pseudouridine synthase activity
HF196_RS01925	COG2333	competence protein COMEC
HF196_RS01925	COG0658	competence protein
HF196_RS01940	COG1674	ftsk spoiiie
HF196_RS01945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HF196_RS01950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HF196_RS01955	COG0047	phosphoribosylformylglycinamidine synthase activity
HF196_RS01960	COG0581	inorganic phosphate transmembrane transporter activity
HF196_RS01970	COG0336	Belongs to the RNA methyltransferase TrmD family
HF196_RS01975	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HF196_RS01980	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HF196_RS01985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HF196_RS01995	COG0473	3-isopropylmalate dehydrogenase activity
HF196_RS02020	COG2814	Major facilitator Superfamily
HF196_RS02040	COG0772	Belongs to the SEDS family
HF196_RS02065	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HF196_RS02080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HF196_RS02090	COG0839	Belongs to the complex I subunit 6 family
HF196_RS02095	COG0713	ATP synthesis coupled electron transport
HF196_RS02100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HF196_RS02105	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF196_RS02110	COG1007	ATP synthesis coupled electron transport
HF196_RS02115	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HF196_RS02115	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HF196_RS02125	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HF196_RS02130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HF196_RS02135	COG1862	Preprotein translocase
HF196_RS02140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HF196_RS02155	COG0571	ribonuclease III activity
HF196_RS02185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HF196_RS02195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HF196_RS02205	COG0156	8-amino-7-oxononanoate synthase activity
HF196_RS02235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HF196_RS02240	COG2205	protein histidine kinase activity
HF196_RS02240	COG2202	Pas domain
HF196_RS02245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HF196_RS02250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HF196_RS02260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HF196_RS02270	COG1758	RNA polymerase activity
HF196_RS02300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HF196_RS02310	COG0482	sulfurtransferase activity
HF196_RS02325	COG2885	chlorophyll binding
HF196_RS02335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HF196_RS02345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HF196_RS02360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HF196_RS02375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HF196_RS02385	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF196_RS02390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HF196_RS02410	COG0823	Involved in the tonB-independent uptake of proteins
HF196_RS02420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HF196_RS02430	COG4695	Portal protein
HF196_RS02460	COG0629	single-stranded DNA binding
HF196_RS02490	COG0543	2 iron, 2 sulfur cluster binding
HF196_RS02490	COG0493	'glutamate synthase
HF196_RS02520	COG1063	alcohol dehydrogenase
HF196_RS02555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HF196_RS02560	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HF196_RS02565	COG0194	GDP metabolic process
HF196_RS02590	COG0024	Methionine aminopeptidase
HF196_RS02595	COG0113	porphobilinogen synthase activity
HF196_RS02640	COG0505	Belongs to the CarA family
HF196_RS02655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HF196_RS02670	COG0250	Participates in transcription elongation, termination and antitermination
HF196_RS02675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HF196_RS02680	COG0081	regulation of translation
HF196_RS02685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HF196_RS02690	COG0222	ribosome binding
HF196_RS02695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HF196_RS02695	COG0085	RNA polymerase activity
HF196_RS02715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HF196_RS02745	COG4133	protoheme IX ABC transporter activity
HF196_RS02755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HF196_RS02780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HF196_RS02785	COG0259	pyridoxamine-phosphate oxidase activity
HF196_RS02790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HF196_RS02800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HF196_RS02825	COG0316	Belongs to the HesB IscA family
HF196_RS02830	COG0822	iron-sulfur transferase activity
HF196_RS02835	COG0552	protein localization to endoplasmic reticulum
HF196_RS02840	COG0527	aspartate kinase activity
HF196_RS02875	COG0494	nUDIX hydrolase
HF196_RS02880	COG0084	hydrolase, TatD family'
HF196_RS02890	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF196_RS02895	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF196_RS02900	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF196_RS02905	COG0537	adenosine 5'-monophosphoramidase activity
HF196_RS02920	COG1090	epimerase
HF196_RS02930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HF196_RS02940	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HF196_RS02960	COG0776	regulation of translation
HF196_RS02980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HF196_RS02990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HF196_RS02995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HF196_RS03000	COG0142	geranyltranstransferase activity
HF196_RS03010	COG0651	ATP synthesis coupled electron transport
HF196_RS03030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HF196_RS03040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HF196_RS03070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HF196_RS03080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HF196_RS03085	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HF196_RS03120	COG3451	type IV secretory pathway VirB4
HF196_RS03140	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF196_RS03155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HF196_RS03170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HF196_RS03175	COG0142	geranyltranstransferase activity
HF196_RS03185	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HF196_RS03195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HF196_RS03200	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HF196_RS03210	COG0307	riboflavin synthase, alpha
HF196_RS03230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HF196_RS03250	COG0237	dephospho-CoA kinase activity
HF196_RS03255	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HF196_RS03265	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF196_RS03280	COG0653	protein targeting
HF196_RS03300	COG0752	glycyl-tRNA synthetase alpha subunit
HF196_RS03305	COG0751	glycine-tRNA ligase activity
HF196_RS03310	COG0322	excinuclease ABC activity
HF196_RS03315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HF196_RS03320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HF196_RS03320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HF196_RS03350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HF196_RS03355	COG0573	inorganic phosphate transmembrane transporter activity
HF196_RS03360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HF196_RS03365	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HF196_RS03375	COG0492	ferredoxin-NADP+ reductase activity
HF196_RS03380	COG0126	phosphoglycerate kinase activity
HF196_RS03400	COG0215	cysteine-tRNA ligase activity
HF196_RS03405	COG3932	Exopolysaccharide synthesis, ExoD
HF196_RS03415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HF196_RS03420	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HF196_RS03450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HF196_RS03485	COG1138	Cytochrome C-type biogenesis protein
HF196_RS03490	COG1396	sequence-specific DNA binding
HF196_RS03535	COG1115	amino acid carrier protein
HF196_RS03550	COG3505	Type IV secretory pathway VirD4
HF196_RS03555	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HF196_RS03570	COG3736	Type IV secretory pathway, component VirB8
HF196_RS03590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HF196_RS03605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HF196_RS03650	COG1268	BioY protein
HF196_RS03660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HF196_RS03670	COG0045	succinate-CoA ligase (ADP-forming) activity
HF196_RS03690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HF196_RS03700	COG0372	Belongs to the citrate synthase family
HF196_RS03715	COG4974	Belongs to the 'phage' integrase family
HF196_RS03720	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HF196_RS03725	COG0628	permease
HF196_RS03730	COG0477	Major facilitator Superfamily
HF196_RS03765	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HF196_RS03780	COG2890	protein-(glutamine-N5) methyltransferase activity
HF196_RS03790	COG0354	folic acid binding
HF196_RS03795	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HF196_RS03850	COG0330	HflC and HflK could
HF196_RS03890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HF196_RS03895	COG1121	(ABC) transporter
HF196_RS03920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HF196_RS03925	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HF196_RS03925	COG2857	Cytochrome c1
HF196_RS03930	COG0556	nucleotide-excision repair
HF196_RS03945	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HF196_RS03945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HF196_RS03955	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HF196_RS03960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HF196_RS03965	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HF196_RS03975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HF196_RS03985	COG1301	dicarboxylic acid transport
HF196_RS03990	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HF196_RS04015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HF196_RS04025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HF196_RS04050	COG0071	Belongs to the small heat shock protein (HSP20) family
HF196_RS04115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HF196_RS04120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HF196_RS04130	COG0542	response to heat
HF196_RS04135	COG2902	Dehydrogenase
HF196_RS04170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HF196_RS04180	COG0575	Belongs to the CDS family
HF196_RS04185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HF196_RS04190	COG0233	cytoplasmic translational termination
HF196_RS04195	COG0528	UMP kinase activity
HF196_RS04200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HF196_RS04205	COG0052	Belongs to the universal ribosomal protein uS2 family
HF196_RS04215	COG1271	oxidase subunit
HF196_RS04220	COG1294	oxidase, subunit
HF196_RS04255	COG0312	modulator of DNA gyrase
HF196_RS04280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HF196_RS04290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HF196_RS04315	COG0544	peptidyl-prolyl cis-trans isomerase activity
HF196_RS04320	COG0740	serine-type endopeptidase activity
HF196_RS04325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HF196_RS04330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HF196_RS04335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HF196_RS04340	COG1181	Belongs to the D-alanine--D-alanine ligase family
HF196_RS04345	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HF196_RS04350	COG0758	DNA mediated transformation
HF196_RS04360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HF196_RS04365	COG0450	alkyl hydroperoxide reductase
HF196_RS04380	COG4974	Belongs to the 'phage' integrase family
HF196_RS04400	COG1530	ribonuclease E activity
HF196_RS04405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HF196_RS04420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HF196_RS04430	COG0359	binds to the 23S rRNA
HF196_RS04440	COG0360	Binds together with S18 to 16S ribosomal RNA
HF196_RS04455	COG2003	Belongs to the UPF0758 family
HF196_RS04565	COG0574	Belongs to the PEP-utilizing enzyme family
HF196_RS04565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HF196_RS04580	COG0477	Major facilitator Superfamily
HF196_RS04590	COG0590	tRNA wobble adenosine to inosine editing
HF196_RS04595	COG0504	CTP synthase activity
HF196_RS04605	COG2003	Belongs to the UPF0758 family
HF196_RS04610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HF196_RS04625	COG0489	protein tyrosine kinase activity
HF196_RS04635	COG1686	Belongs to the peptidase S11 family
HF196_RS04645	COG0617	tRNA 3'-terminal CCA addition
HF196_RS04655	COG0012	GTP binding
HF196_RS04665	COG1494	fructose-1,6-bisphosphatase
HF196_RS04695	COG0022	dehydrogenase e1 component
HF196_RS04695	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF196_RS04700	COG2239	Acts as a magnesium transporter
HF196_RS04720	COG0071	Belongs to the small heat shock protein (HSP20) family
HF196_RS04740	COG0805	protein transport
HF196_RS04760	COG0109	protoheme IX farnesyltransferase activity
HF196_RS04765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HF196_RS04770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HF196_RS04775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HF196_RS04800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HF196_RS04805	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HF196_RS04810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HF196_RS04825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HF196_RS04835	COG1322	Protein conserved in bacteria
HF196_RS04860	COG0284	orotidine-5'-phosphate decarboxylase activity
HF196_RS04870	COG0525	valine-tRNA ligase activity
HF196_RS04985	COG0666	response to abiotic stimulus
HF196_RS05035	COG0484	heat shock protein binding
HF196_RS05055	COG1132	(ABC) transporter
HF196_RS05065	COG0018	arginyl-trna synthetase
HF196_RS05100	COG1475	DNA binding
HF196_RS05150	COG2814	Major facilitator Superfamily
HF196_RS05155	COG0564	pseudouridine synthase activity
HF196_RS05170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HF196_RS05185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HF196_RS05220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HF196_RS05230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HF196_RS05235	COG1074	ATP-dependent DNA helicase activity
HF196_RS05250	COG0072	phenylalanine-tRNA ligase activity
HF196_RS05250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HF196_RS05330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HF196_RS05350	COG0202	RNA polymerase activity
HF196_RS05355	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HF196_RS05360	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HF196_RS05370	COG0201	protein transport
HF196_RS05380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HF196_RS05385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HF196_RS05395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HF196_RS05400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HF196_RS05410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HF196_RS05415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HF196_RS05420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HF196_RS05430	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HF196_RS05435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HF196_RS05440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HF196_RS05445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HF196_RS05450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HF196_RS05460	COG0088	Forms part of the polypeptide exit tunnel
HF196_RS05465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HF196_RS05475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HF196_RS05480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HF196_RS05490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HF196_RS05520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HF196_RS05540	COG0567	Dehydrogenase, E1 component
HF196_RS05565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HF196_RS05575	COG1295	ribonuclease BN
HF196_RS05580	COG4221	oxidoreductase activity
HF196_RS05595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HF196_RS05595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HF196_RS05605	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HF196_RS05610	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HF196_RS05625	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HF196_RS05670	COG0187	DNA topoisomerase II activity
HF196_RS05695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HF196_RS05705	COG0280	phosphate acetyltransferase
HF196_RS05705	COG0281	malic enzyme
HF196_RS05710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HF196_RS05720	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HF196_RS05760	COG0481	GTPase activity
HF196_RS05765	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HF196_RS05780	COG0812	UDP-N-acetylmuramate dehydrogenase activity