locus-tag	class	description
HF197_RS00035	ENOG4105F8V	Hydrolase, tatD family
HF197_RS00075	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HF197_RS00080	ENOG4108WIW	Aspartyl protease
HF197_RS00100	ENOG4105FA0	parb-like partition protein
HF197_RS00115	ENOG4108EHY	type IV secretion system
HF197_RS00120	ENOG4105CMA	conjugation trbi family protein
HF197_RS00130	ENOG4108V42	Type IV secretion system protein VirB8
HF197_RS00135	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HF197_RS00180	ENOG4108IEH	NADH dehydrogenase subunit g
HF197_RS00190	ENOG4105K46	50S ribosomal protein l27
HF197_RS00240	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF197_RS00250	ENOG4105C9M	aspartyl-trna synthetase
HF197_RS00295	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HF197_RS00310	ENOG4105K59	histidine triad (HIT) protein
HF197_RS00315	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HF197_RS00325	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HF197_RS00350	ENOG4108R6K	riboflavin synthase, subunit alpha
HF197_RS00385	ENOG4105C3M	thioredoxin reductase
HF197_RS00390	ENOG4105D3R	alkyl hydroperoxide reductase
HF197_RS00395	ENOG4108UFP	Essential cell division protein (By similarity)
HF197_RS00415	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HF197_RS00430	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HF197_RS00465	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HF197_RS00495	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HF197_RS00510	ENOG4105EKQ	RNA-directed DNA polymerase
HF197_RS00520	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HF197_RS00555	ENOG4105EKQ	RNA-directed DNA polymerase
HF197_RS00565	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
HF197_RS00600	ENOG4105EKQ	RNA-directed DNA polymerase
HF197_RS00635	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HF197_RS00650	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HF197_RS00660	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HF197_RS00670	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HF197_RS00675	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HF197_RS00690	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HF197_RS00710	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HF197_RS00725	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HF197_RS00735	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HF197_RS00745	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HF197_RS00755	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HF197_RS00765	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HF197_RS00775	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HF197_RS00785	ENOG41082FP	UPF0102 protein
HF197_RS00790	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HF197_RS00800	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HF197_RS00820	ENOG4107RIZ	hflk protein
HF197_RS00825	ENOG4105EPW	hflc protein
HF197_RS00850	ENOG4107R3N	Filamentation induced by cAMP protein fic
HF197_RS00890	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HF197_RS00915	ENOG4105C3F	Signal peptidase i
HF197_RS00925	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HF197_RS00930	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HF197_RS00955	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HF197_RS00965	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HF197_RS00995	ENOG4105CNI	cell division protein FtsW
HF197_RS01020	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HF197_RS01035	ENOG4105FAV	ABC, transporter
HF197_RS01055	ENOG4107QX3	carboxylase
HF197_RS01090	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HF197_RS01095	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HF197_RS01105	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HF197_RS01155	ENOG4105BZA	Phosphoglycerate kinase
HF197_RS01170	ENOG4105CB5	ATP-dependent DNA helicase recG
HF197_RS01180	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HF197_RS01185	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HF197_RS01225	ENOG4105K6T	rare lipoprotein A
HF197_RS01340	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HF197_RS01350	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
HF197_RS01365	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HF197_RS01380	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HF197_RS01410	ENOG4105MP9	class II Aldolase
HF197_RS01415	ENOG4105C7S	Dehydrogenase
HF197_RS01445	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HF197_RS01450	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
HF197_RS01485	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HF197_RS01490	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HF197_RS01510	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HF197_RS01610	ENOG4105CSH	Transporter
HF197_RS01620	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HF197_RS01630	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HF197_RS01655	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HF197_RS01675	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
HF197_RS01685	ENOG4108ZAI	phosphatidylglycerophosphatase a
HF197_RS01705	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HF197_RS01715	ENOG4108Z1B	Cyclase dehydrase
HF197_RS01725	ENOG4105BZG	amino acid carrier protein
HF197_RS01730	ENOG4105BZG	amino acid carrier protein
HF197_RS01735	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HF197_RS01740	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HF197_RS01750	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HF197_RS01755	ENOG4107QI6	Cysteine desulfurase
HF197_RS01760	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HF197_RS01765	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HF197_RS01770	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
HF197_RS01780	ENOG4105C1V	Peptidase, M16
HF197_RS01790	ENOG4105D5Q	Arginine ornithine antiporter
HF197_RS01860	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HF197_RS01895	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HF197_RS01910	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HF197_RS01915	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
HF197_RS01955	ENOG4105CE9	30S ribosomal protein S2
HF197_RS01960	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HF197_RS01965	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HF197_RS01980	ENOG4105KNE	Phosphatidate cytidylyltransferase
HF197_RS02020	ENOG4107QKV	phosphomannomutase
HF197_RS02025	ENOG4105K5M	30s ribosomal protein S16
HF197_RS02030	ENOG4105EAH	synthase
HF197_RS02035	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HF197_RS02075	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HF197_RS02080	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HF197_RS02100	ENOG4108JJ6	Type I secretion system ATPase
HF197_RS02170	ENOG4108JYK	Dehydrogenase
HF197_RS02175	ENOG4108YXA	Membrane
HF197_RS02190	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HF197_RS02195	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HF197_RS02260	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HF197_RS02270	ENOG4105CJN	penicillin-binding protein
HF197_RS02295	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HF197_RS02300	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HF197_RS02305	ENOG4105CTB	Polyprenyl synthetase
HF197_RS02350	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HF197_RS02410	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HF197_RS02415	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HF197_RS02420	ENOG4108WRK	Transcriptional regulator
HF197_RS02460	ENOG4108RCM	Nitroreductase
HF197_RS02490	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HF197_RS02500	ENOG4105M85	Bola protein
HF197_RS02525	ENOG41081BE	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HF197_RS02530	ENOG4105C7I	Dehydrogenase
HF197_RS02535	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HF197_RS02545	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HF197_RS02550	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HF197_RS02555	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HF197_RS02575	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HF197_RS02580	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HF197_RS02585	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HF197_RS02595	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HF197_RS02630	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HF197_RS02635	ENOG41082FS	50S ribosomal protein L31
HF197_RS02640	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HF197_RS02675	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HF197_RS02705	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HF197_RS02715	ENOG4105K63	Thioredoxin
HF197_RS02820	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HF197_RS02845	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HF197_RS02850	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HF197_RS02880	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HF197_RS02945	ENOG4105F0N	pyrophosphate phospho-hydrolase
HF197_RS02980	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HF197_RS02990	ENOG4105CAY	ferredoxin--nadp reductase
HF197_RS02995	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HF197_RS03000	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HF197_RS03010	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HF197_RS03020	ENOG41082WC	Transport-associated protein
HF197_RS03025	ENOG4105D7Z	glutathione synthase
HF197_RS03085	ENOG4105CI3	gtp-binding protein typa
HF197_RS03115	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HF197_RS03135	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HF197_RS03145	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HF197_RS03155	ENOG4105C8S	subunit m
HF197_RS03170	ENOG41067UH	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HF197_RS03180	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HF197_RS03205	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
HF197_RS03220	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HF197_RS03225	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HF197_RS03250	ENOG4105EIE	fructose-bisphosphate aldolase
HF197_RS03260	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HF197_RS03265	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HF197_RS03270	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HF197_RS03280	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HF197_RS03360	ENOG4105CBT	Fructose-1,6-bisphosphatase
HF197_RS03370	ENOG4108Z4U	Ferredoxin
HF197_RS03385	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HF197_RS03455	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HF197_RS03475	ENOG4105EA8	2-Nitropropane dioxygenase
HF197_RS03515	ENOG4108VZM	50s ribosomal protein L10
HF197_RS03520	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HF197_RS03525	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HF197_RS03530	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HF197_RS03545	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HF197_RS03580	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HF197_RS03595	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HF197_RS03600	ENOG4105CSH	Transporter
HF197_RS03620	ENOG4107QM5	aconitate hydratase
HF197_RS03645	ENOG4105CGK	Exodeoxyribonuclease III
HF197_RS03655	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HF197_RS03660	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HF197_RS03685	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HF197_RS03690	ENOG4105CPP	Dehydrogenase, E1 component
HF197_RS03710	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HF197_RS03715	ENOG4107QN2	dihydrolipoyl dehydrogenase
HF197_RS03745	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HF197_RS03750	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HF197_RS03755	ENOG4105BZG	amino acid carrier protein
HF197_RS03785	ENOG4105DF2	NADH dehydrogenase subunit j
HF197_RS03790	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF197_RS03805	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF197_RS03810	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HF197_RS03820	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
HF197_RS03835	ENOG4105C4R	Atp-dependent dna helicase
HF197_RS03860	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HF197_RS03865	ENOG4105EIX	cytochrome c1
HF197_RS03870	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
HF197_RS03925	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HF197_RS03945	ENOG4105DHZ	alpha beta
HF197_RS03950	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HF197_RS03960	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HF197_RS03965	ENOG4105D1F	ATP-binding protein
HF197_RS03985	ENOG4105RHY	Pfam:UPF0157
HF197_RS03995	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HF197_RS04010	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HF197_RS04015	ENOG4108IJ6	ABC transporter
HF197_RS04035	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HF197_RS04085	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HF197_RS04115	ENOG4105C6K	Malic enzyme
HF197_RS04120	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HF197_RS04140	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HF197_RS04145	ENOG4105Y2X	UPF0335 protein
HF197_RS04150	ENOG4108JU6	CBS domain protein
HF197_RS04170	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HF197_RS04180	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HF197_RS04185	ENOG4105DZP	Membrane-associated zinc metalloprotease
HF197_RS04225	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HF197_RS04265	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HF197_RS04280	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HF197_RS04290	ENOG4105C02	permease
HF197_RS04300	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HF197_RS04320	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
HF197_RS04350	ENOG4105DWF	phosphomethylpyrimidine kinase
HF197_RS04355	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HF197_RS04375	ENOG4105CAS	nag kinase
HF197_RS04385	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HF197_RS04415	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HF197_RS04420	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HF197_RS04430	ENOG4105EKQ	RNA-directed DNA polymerase
HF197_RS04480	ENOG4105DZ1	carboxypeptidase
HF197_RS04495	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HF197_RS04500	ENOG4105HFZ	Membrane
HF197_RS04505	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
HF197_RS04520	ENOG4105ETU	transcriptional activator (TenA
HF197_RS04545	ENOG4105DC7	peptidase M24
HF197_RS04560	ENOG4108Z4V	iron-sulfur cluster assembly
HF197_RS04565	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HF197_RS04590	ENOG4105DHP	deoxycytidine triphosphate deaminase
HF197_RS04595	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HF197_RS04620	ENOG4105CUT	histidyl-tRNA synthetase
HF197_RS04630	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
HF197_RS04645	ENOG4105DA4	cytochrome c-type biogenesis protein
HF197_RS04675	ENOG4105MJ2	Competence protein
HF197_RS04690	ENOG4105BZ1	(ABC) transporter
HF197_RS04695	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HF197_RS04700	ENOG4105CFQ	glutamine synthetase
HF197_RS04710	ENOG41082IR	Excinuclease ABC C subunit domain protein
HF197_RS04740	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HF197_RS04755	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HF197_RS04770	ENOG4105K63	Thioredoxin
HF197_RS04815	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HF197_RS04870	ENOG4105D52	delta-aminolevulinic acid dehydratase
HF197_RS04885	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HF197_RS04895	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HF197_RS04900	ENOG4108VX5	3-methyladenine DNA glycosylase
HF197_RS04920	ENOG4105G9V	cytochrome C
HF197_RS04935	ENOG4105VF7	tolerance protein
HF197_RS04955	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HF197_RS04960	ENOG4105C75	arginyL-tRNA synthetase
HF197_RS04985	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HF197_RS05005	ENOG4108JPZ	Monovalent cation H antiporter subunit D
HF197_RS05015	ENOG4105C8T	Leucyl-tRNA synthetase
HF197_RS05025	ENOG4105CFH	Aspartokinase
HF197_RS05060	ENOG4105CJW	magnesium transporter
HF197_RS05080	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HF197_RS05085	ENOG4107QN2	dihydrolipoyl dehydrogenase
HF197_RS05105	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HF197_RS05110	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HF197_RS05135	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HF197_RS05160	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HF197_RS05170	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
HF197_RS05215	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HF197_RS05220	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HF197_RS05260	ENOG4105C8N	cysteinyl-tRNA synthetase
HF197_RS05275	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HF197_RS05335	ENOG4108QTG	type IV secretion system protein
HF197_RS05355	ENOG4105C8U	phosphate abc transporter
HF197_RS05360	ENOG4105VG0	50S ribosomal protein l34
HF197_RS05380	ENOG4105EKQ	RNA-directed DNA polymerase
HF197_RS05385	ENOG4105C72	UPF0176 protein
HF197_RS05395	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HF197_RS05410	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
HF197_RS05430	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HF197_RS05435	ENOG4105M2J	Glutaredoxin
HF197_RS05440	ENOG4107VCP	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HF197_RS05445	ENOG4105CK2	sodium dicarboxylate symporter
HF197_RS05460	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HF197_RS05480	ENOG4105CP7	Triose-phosphate isomerase
HF197_RS05505	ENOG41087N0	50S ribosomal protein L36
HF197_RS05540	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HF197_RS05550	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HF197_RS05555	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HF197_RS05560	ENOG4105VGS	50s ribosomal protein l32
HF197_RS05605	ENOG4108ZX6	Electron transport protein SCO1 SenC
HF197_RS05610	ENOG4107RZZ	dna polymerase iii epsilon subunit
HF197_RS05625	ENOG41080IJ	Diacylglycerol kinase
HF197_RS05655	ENOG4105C1J	atp-dependent rna helicase
HF197_RS05660	ENOG4105VEQ	Cold shock protein
HF197_RS05680	ENOG4105CSH	Transporter
HF197_RS05695	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HF197_RS05705	ENOG4105W0E	50S ribosomal protein L33
HF197_RS05710	ENOG4105C03	ribonuclease
HF197_RS05715	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HF197_RS05730	ENOG4105DWF	phosphomethylpyrimidine kinase
HF197_RS05735	ENOG4105DWF	phosphomethylpyrimidine kinase
HF197_RS05740	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
HF197_RS05745	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HF197_RS05760	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HF197_RS05775	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HF197_RS05790	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HF197_RS05805	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HF197_RS05810	ENOG4105KDC	50s ribosomal protein l28
HF197_RS05820	ENOG4105BZU	Histidine kinase
HF197_RS05825	ENOG4105C8Y	Acetylornithine aminotransferase
HF197_RS05850	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HF197_RS05870	ENOG4105FDK	ABC transporter
HF197_RS05945	ENOG4107RDP	Dehydrogenase
HF197_RS05950	ENOG4105C3J	Cysteine desulfurase
HF197_RS05960	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HF197_RS05965	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HF197_RS05975	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HF197_RS05980	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HF197_RS05990	ENOG4108Z4V	iron-sulfur cluster assembly
HF197_RS05995	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HF197_RS06000	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HF197_RS06015	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
HF197_RS06070	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HF197_RS06085	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HF197_RS06095	ENOG4105CNU	cell division protein FtsK
HF197_RS06105	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HF197_RS06125	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HF197_RS06135	ENOG4107QIZ	NADH dehydrogenase
HF197_RS06155	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HF197_RS06160	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HF197_RS06180	ENOG41060IM	Heme exporter protein
HF197_RS06185	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HF197_RS06190	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HF197_RS06220	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HF197_RS06225	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HF197_RS06300	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HF197_RS06315	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HF197_RS06375	ENOG4105WVQ	Fe-S assembly protein IscX
HF197_RS06405	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HF197_RS06415	ENOG4105KWW	Biogenesis protein
HF197_RS06455	ENOG4105C3G	gtp-binding protein
HF197_RS06515	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HF197_RS06535	ENOG4105VQU	rdd domain containing protein
HF197_RS06570	ENOG4105CDU	Replicative dna helicase
HF197_RS06600	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HF197_RS06605	ENOG4105C2C	drug resistance transporter, Bcr CflA
HF197_RS06610	ENOG4105EE5	Membrane protein terC
HF197_RS06625	ENOG4105DJV	ribulose-phosphate 3-epimerase
HF197_RS06635	ENOG4108Z6B	deaminase
HF197_RS06645	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HF197_RS06655	ENOG4105W5Q	DNA repair protein (RadC
HF197_RS06670	ENOG4105BZN	citrate synthase
HF197_RS06675	ENOG4105E33	succinate dehydrogenase
HF197_RS06685	ENOG4105DR5	peptidase
HF197_RS06695	ENOG4107XMQ	Peptidyl-prolyl cis-trans isomerase
HF197_RS06740	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HF197_RS06755	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HF197_RS06760	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HF197_RS06770	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HF197_RS06855	ENOG4105EKQ	RNA-directed DNA polymerase
HF197_RS06900	ENOG4105CEC	DNA methylase N-4 N-6
HF197_RS06935	ENOG4105ERU	peptidase
HF197_RS07070	ENOG4105EKQ	RNA-directed DNA polymerase
HF197_RS07085	ENOG4105W5Q	DNA repair protein (RadC
HF197_RS07105	ENOG41089UC	methyltransferase, type 11
HF197_RS07115	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HF197_RS07125	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HF197_RS07140	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HF197_RS07150	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HF197_RS07155	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HF197_RS07160	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
HF197_RS07175	ENOG4105PGM	cation diffusion facilitator family transporter
HF197_RS07180	ENOG4105DHJ	ABC, transporter
HF197_RS07185	ENOG4105CY3	ABC transporter, permease
HF197_RS07190	ENOG4107U9T	Pfam:Ribonuclease_BN
HF197_RS07195	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
HF197_RS07220	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HF197_RS07260	ENOG4105C83	adenylosuccinate lyase
HF197_RS07265	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HF197_RS07275	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HF197_RS07295	ENOG4105C3J	Cysteine desulfurase
HF197_RS07310	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase