locus-tag	class	description
HF197_RS00030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HF197_RS00030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HF197_RS00035	COG0084	hydrolase, TatD family'
HF197_RS00080	COG3577	Aspartyl protease
HF197_RS00100	COG1475	DNA binding
HF197_RS00105	COG0436	Aminotransferase
HF197_RS00110	COG3505	Type IV secretory pathway VirD4
HF197_RS00115	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HF197_RS00120	COG2948	multi-organism process
HF197_RS00130	COG3736	Type IV secretory pathway, component VirB8
HF197_RS00135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HF197_RS00135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HF197_RS00180	COG1034	ATP synthesis coupled electron transport
HF197_RS00190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HF197_RS00240	COG0649	NAD binding
HF197_RS00250	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HF197_RS00295	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HF197_RS00315	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF197_RS00325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF197_RS00345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HF197_RS00350	COG0307	riboflavin synthase, alpha
HF197_RS00385	COG0492	ferredoxin-NADP+ reductase activity
HF197_RS00390	COG0450	alkyl hydroperoxide reductase
HF197_RS00395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HF197_RS00415	COG0723	plastoquinol--plastocyanin reductase activity
HF197_RS00425	COG0612	Peptidase, M16
HF197_RS00430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HF197_RS00465	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HF197_RS00495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HF197_RS00510	COG3344	reverse transcriptase
HF197_RS00520	COG0356	it plays a direct role in the translocation of protons across the membrane
HF197_RS00525	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HF197_RS00555	COG3344	reverse transcriptase
HF197_RS00565	COG0356	it plays a direct role in the translocation of protons across the membrane
HF197_RS00570	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HF197_RS00600	COG3344	reverse transcriptase
HF197_RS00635	COG0505	Belongs to the CarA family
HF197_RS00650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HF197_RS00660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HF197_RS00670	COG0089	rRNA binding
HF197_RS00675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HF197_RS00690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HF197_RS00710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HF197_RS00725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HF197_RS00735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HF197_RS00745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HF197_RS00755	COG0201	protein transport
HF197_RS00765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HF197_RS00775	COG0202	RNA polymerase activity
HF197_RS00785	COG0792	nuclease activity
HF197_RS00790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HF197_RS00800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HF197_RS00825	COG0330	HflC and HflK could
HF197_RS00850	COG3177	Filamentation induced by cAMP protein fic
HF197_RS00890	COG0653	protein targeting
HF197_RS00915	COG0681	Belongs to the peptidase S26 family
HF197_RS00925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HF197_RS00930	COG0154	amidase activity
HF197_RS00950	COG0666	response to abiotic stimulus
HF197_RS00955	COG0156	8-amino-7-oxononanoate synthase activity
HF197_RS00965	COG0326	Molecular chaperone. Has ATPase activity
HF197_RS00995	COG0772	Belongs to the SEDS family
HF197_RS01020	COG1074	ATP-dependent DNA helicase activity
HF197_RS01035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HF197_RS01055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HF197_RS01090	COG0445	tRNA wobble uridine modification
HF197_RS01095	COG2890	protein-(glutamine-N5) methyltransferase activity
HF197_RS01105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HF197_RS01155	COG0126	phosphoglycerate kinase activity
HF197_RS01170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HF197_RS01180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HF197_RS01185	COG0567	Dehydrogenase, E1 component
HF197_RS01225	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HF197_RS01245	COG0187	DNA topoisomerase II activity
HF197_RS01285	COG0114	fumarate hydratase activity
HF197_RS01340	COG0459	protein refolding
HF197_RS01365	COG0045	succinate-CoA ligase (ADP-forming) activity
HF197_RS01380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HF197_RS01410	COG0235	Class ii aldolase
HF197_RS01415	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF197_RS01445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HF197_RS01450	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HF197_RS01485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HF197_RS01490	COG2226	methyltransferase
HF197_RS01510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HF197_RS01610	COG0477	Major facilitator Superfamily
HF197_RS01620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HF197_RS01630	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HF197_RS01655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HF197_RS01675	COG0745	RESPONSE REGULATOR receiver
HF197_RS01685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HF197_RS01705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HF197_RS01715	COG2867	negative regulation of translational initiation
HF197_RS01725	COG1115	amino acid carrier protein
HF197_RS01730	COG1115	amino acid carrier protein
HF197_RS01735	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HF197_RS01740	COG0237	dephospho-CoA kinase activity
HF197_RS01750	COG2171	N-acyltransferase activity
HF197_RS01755	COG1104	cysteine desulfurase activity
HF197_RS01760	COG0849	cell division
HF197_RS01765	COG0242	peptide deformylase activity
HF197_RS01770	COG1573	uracil-dna glycosylase
HF197_RS01775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HF197_RS01780	COG0612	Peptidase, M16
HF197_RS01790	COG0531	amino acid
HF197_RS01860	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HF197_RS01895	COG0617	tRNA 3'-terminal CCA addition
HF197_RS01910	COG1183	phosphatidylcholine synthase activity
HF197_RS01915	COG0284	orotidine-5'-phosphate decarboxylase activity
HF197_RS01930	COG0666	response to abiotic stimulus
HF197_RS01935	COG1840	ABC-type Fe3 transport system, periplasmic component
HF197_RS01955	COG0052	Belongs to the universal ribosomal protein uS2 family
HF197_RS01960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HF197_RS01965	COG0528	UMP kinase activity
HF197_RS01980	COG0575	Belongs to the CDS family
HF197_RS02020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HF197_RS02025	COG0228	four-way junction DNA binding
HF197_RS02030	COG0142	geranyltranstransferase activity
HF197_RS02035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HF197_RS02050	COG0552	protein localization to endoplasmic reticulum
HF197_RS02075	COG0358	DNA primase activity
HF197_RS02080	COG0101	tRNA pseudouridine synthase activity
HF197_RS02170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HF197_RS02190	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HF197_RS02195	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HF197_RS02260	COG0343	queuine tRNA-ribosyltransferase activity
HF197_RS02265	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HF197_RS02270	COG0768	penicillin binding
HF197_RS02295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HF197_RS02300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HF197_RS02305	COG0142	geranyltranstransferase activity
HF197_RS02350	COG0556	nucleotide-excision repair
HF197_RS02410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HF197_RS02415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HF197_RS02420	COG1396	sequence-specific DNA binding
HF197_RS02495	COG0626	cystathionine gamma-synthase activity
HF197_RS02500	COG0271	Belongs to the BolA IbaG family
HF197_RS02525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HF197_RS02530	COG2902	Dehydrogenase
HF197_RS02535	COG0542	response to heat
HF197_RS02545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HF197_RS02550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HF197_RS02555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HF197_RS02575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HF197_RS02580	COG0539	negative regulation of cytoplasmic translation
HF197_RS02585	COG0776	regulation of translation
HF197_RS02595	COG0105	UTP biosynthetic process
HF197_RS02630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HF197_RS02635	COG0254	rRNA binding
HF197_RS02640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HF197_RS02675	COG0167	dihydroorotate dehydrogenase activity
HF197_RS02705	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HF197_RS02820	COG0823	Involved in the tonB-independent uptake of proteins
HF197_RS02850	COG0805	protein transport
HF197_RS02880	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HF197_RS02945	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HF197_RS02980	COG0756	dUTP diphosphatase activity
HF197_RS02990	COG0492	ferredoxin-NADP+ reductase activity
HF197_RS02995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HF197_RS03000	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HF197_RS03010	COG0544	peptidyl-prolyl cis-trans isomerase activity
HF197_RS03075	COG1322	Protein conserved in bacteria
HF197_RS03115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HF197_RS03135	COG1619	proteins homologs of microcin C7 resistance protein MccF
HF197_RS03145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HF197_RS03155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HF197_RS03155	COG2111	Na H antiporter
HF197_RS03170	COG1758	RNA polymerase activity
HF197_RS03180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HF197_RS03205	COG4133	protoheme IX ABC transporter activity
HF197_RS03220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HF197_RS03220	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HF197_RS03225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HF197_RS03235	COG0473	3-isopropylmalate dehydrogenase activity
HF197_RS03250	COG1830	Aldolase
HF197_RS03260	COG0316	Belongs to the HesB IscA family
HF197_RS03265	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HF197_RS03270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HF197_RS03270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HF197_RS03280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HF197_RS03285	COG0629	single-stranded DNA binding
HF197_RS03340	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HF197_RS03360	COG1494	fructose-1,6-bisphosphatase
HF197_RS03385	COG0484	heat shock protein binding
HF197_RS03455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HF197_RS03475	COG2070	2-Nitropropane dioxygenase
HF197_RS03510	COG0222	ribosome binding
HF197_RS03515	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HF197_RS03520	COG0081	regulation of translation
HF197_RS03525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HF197_RS03530	COG0250	Participates in transcription elongation, termination and antitermination
HF197_RS03545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HF197_RS03570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HF197_RS03580	COG1160	GTP binding
HF197_RS03595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HF197_RS03600	COG0477	Major facilitator Superfamily
HF197_RS03605	COG0666	response to abiotic stimulus
HF197_RS03655	COG0312	modulator of DNA gyrase
HF197_RS03660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HF197_RS03685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HF197_RS03690	COG0022	dehydrogenase e1 component
HF197_RS03690	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF197_RS03710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HF197_RS03715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HF197_RS03745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HF197_RS03750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HF197_RS03755	COG1115	amino acid carrier protein
HF197_RS03790	COG0713	ATP synthesis coupled electron transport
HF197_RS03795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HF197_RS03800	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF197_RS03805	COG1007	ATP synthesis coupled electron transport
HF197_RS03810	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HF197_RS03810	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HF197_RS03820	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HF197_RS03835	COG0210	DNA helicase
HF197_RS03860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HF197_RS03870	COG1178	ABC-type Fe3 transport system permease component
HF197_RS03945	COG2945	thiolester hydrolase activity
HF197_RS03950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HF197_RS03960	COG0525	valine-tRNA ligase activity
HF197_RS03965	COG0489	protein tyrosine kinase activity
HF197_RS03970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HF197_RS03985	COG0456	acetyltransferase
HF197_RS03985	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HF197_RS03995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HF197_RS04010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HF197_RS04015	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HF197_RS04035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HF197_RS04085	COG0312	modulator of DNA gyrase
HF197_RS04115	COG0281	malic enzyme
HF197_RS04115	COG0280	phosphate acetyltransferase
HF197_RS04120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HF197_RS04140	COG0163	prenyltransferase activity
HF197_RS04145	COG3750	Belongs to the UPF0335 family
HF197_RS04150	COG4536	flavin adenine dinucleotide binding
HF197_RS04170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HF197_RS04185	COG0750	zinc metalloprotease
HF197_RS04225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HF197_RS04265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HF197_RS04285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HF197_RS04290	COG0628	permease
HF197_RS04300	COG4974	Belongs to the 'phage' integrase family
HF197_RS04320	COG1381	Involved in DNA repair and RecF pathway recombination
HF197_RS04330	COG4770	biotin carboxylase activity
HF197_RS04350	COG0352	thiamine-phosphate diphosphorylase activity
HF197_RS04350	COG0351	phosphomethylpyrimidine kinase
HF197_RS04350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HF197_RS04355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HF197_RS04355	COG1372	Participates in initiation and elongation during chromosome replication
HF197_RS04375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HF197_RS04385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HF197_RS04390	COG2076	Multidrug Resistance protein
HF197_RS04415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HF197_RS04420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HF197_RS04480	COG1686	Belongs to the peptidase S11 family
HF197_RS04495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HF197_RS04500	COG0670	Belongs to the BI1 family
HF197_RS04505	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HF197_RS04520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HF197_RS04545	COG0006	proline dipeptidase activity
HF197_RS04560	COG0316	Belongs to the HesB IscA family
HF197_RS04565	COG0822	iron-sulfur transferase activity
HF197_RS04570	COG2814	Major facilitator Superfamily
HF197_RS04590	COG0717	Belongs to the dCTP deaminase family
HF197_RS04595	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HF197_RS04620	COG0124	histidyl-tRNA synthetase
HF197_RS04630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HF197_RS04645	COG1138	Cytochrome C-type biogenesis protein
HF197_RS04690	COG1132	(ABC) transporter
HF197_RS04695	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HF197_RS04700	COG0174	glutamine synthetase
HF197_RS04710	COG2827	Endonuclease containing a URI domain
HF197_RS04730	COG0564	pseudouridine synthase activity
HF197_RS04740	COG0072	phenylalanine-tRNA ligase activity
HF197_RS04740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HF197_RS04800	COG0508	dehydrogenase complex catalyzes the overall conversion of
HF197_RS04815	COG1136	(ABC) transporter
HF197_RS04855	COG0564	pseudouridine synthase activity
HF197_RS04870	COG0113	porphobilinogen synthase activity
HF197_RS04885	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HF197_RS04895	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HF197_RS04900	COG2094	Belongs to the DNA glycosylase MPG family
HF197_RS04920	COG3474	cytochrome
HF197_RS04925	COG1845	cytochrome c oxidase, subunit III
HF197_RS04935	COG1324	tolerance protein
HF197_RS04955	COG0736	holo-[acyl-carrier-protein] synthase activity
HF197_RS04960	COG0018	arginyl-trna synthetase
HF197_RS04985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HF197_RS05005	COG0651	ATP synthesis coupled electron transport
HF197_RS05015	COG0495	leucyl-tRNA aminoacylation
HF197_RS05025	COG0527	aspartate kinase activity
HF197_RS05035	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HF197_RS05040	COG2009	succinate dehydrogenase
HF197_RS05060	COG2239	Acts as a magnesium transporter
HF197_RS05070	COG3451	type IV secretory pathway VirB4
HF197_RS05080	COG4974	Belongs to the 'phage' integrase family
HF197_RS05105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HF197_RS05110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HF197_RS05110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HF197_RS05135	COG0047	phosphoribosylformylglycinamidine synthase activity
HF197_RS05170	COG0662	Cupin 2, conserved barrel domain protein
HF197_RS05170	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HF197_RS05215	COG0481	GTPase activity
HF197_RS05220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HF197_RS05260	COG0215	cysteine-tRNA ligase activity
HF197_RS05265	COG3932	Exopolysaccharide synthesis, ExoD
HF197_RS05275	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HF197_RS05305	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HF197_RS05315	COG3451	type IV secretory pathway VirB4
HF197_RS05320	COG3704	protein secretion by the type IV secretion system
HF197_RS05330	COG3704	protein secretion by the type IV secretion system
HF197_RS05335	COG1340	protein secretion by the type IV secretion system
HF197_RS05335	COG3704	protein secretion by the type IV secretion system
HF197_RS05340	COG0419	ATPase involved in DNA repair
HF197_RS05340	COG3704	protein secretion by the type IV secretion system
HF197_RS05360	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HF197_RS05365	COG0594	ribonuclease P activity
HF197_RS05375	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HF197_RS05395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HF197_RS05410	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HF197_RS05430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HF197_RS05435	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HF197_RS05440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HF197_RS05445	COG1301	dicarboxylic acid transport
HF197_RS05460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HF197_RS05480	COG0149	triose-phosphate isomerase activity
HF197_RS05505	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HF197_RS05540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HF197_RS05540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HF197_RS05550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HF197_RS05555	COG0416	fatty acid biosynthetic process
HF197_RS05560	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HF197_RS05605	COG1999	signal sequence binding
HF197_RS05610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HF197_RS05660	COG1278	Cold shock
HF197_RS05680	COG0477	Major facilitator Superfamily
HF197_RS05695	COG0024	Methionine aminopeptidase
HF197_RS05705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HF197_RS05710	COG1530	ribonuclease E activity
HF197_RS05715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HF197_RS05730	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HF197_RS05730	COG0352	thiamine-phosphate diphosphorylase activity
HF197_RS05730	COG0351	phosphomethylpyrimidine kinase
HF197_RS05740	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HF197_RS05745	COG0352	thiamine-phosphate diphosphorylase activity
HF197_RS05760	COG2022	thiamine diphosphate biosynthetic process
HF197_RS05775	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HF197_RS05790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HF197_RS05805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HF197_RS05810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HF197_RS05820	COG2202	Pas domain
HF197_RS05820	COG2205	protein histidine kinase activity
HF197_RS05825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HF197_RS05850	COG0525	valine-tRNA ligase activity
HF197_RS05870	COG1121	(ABC) transporter
HF197_RS05935	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HF197_RS05950	COG1104	cysteine desulfurase activity
HF197_RS05955	COG0697	spore germination
HF197_RS05960	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HF197_RS05975	COG2226	methyltransferase
HF197_RS05980	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HF197_RS05990	COG0316	Belongs to the HesB IscA family
HF197_RS05995	COG0822	iron-sulfur transferase activity
HF197_RS06000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HF197_RS06015	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HF197_RS06060	COG1253	flavin adenine dinucleotide binding
HF197_RS06070	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HF197_RS06085	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HF197_RS06095	COG1674	ftsk spoiiie
HF197_RS06105	COG0321	lipoyl(octanoyl) transferase activity
HF197_RS06125	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HF197_RS06135	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HF197_RS06155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HF197_RS06160	COG0542	response to heat
HF197_RS06180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HF197_RS06185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HF197_RS06190	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HF197_RS06220	COG0138	bifunctional purine biosynthesis protein purh
HF197_RS06225	COG0574	Belongs to the PEP-utilizing enzyme family
HF197_RS06225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HF197_RS06285	COG0666	response to abiotic stimulus
HF197_RS06300	COG0776	regulation of translation
HF197_RS06315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HF197_RS06320	COG0543	2 iron, 2 sulfur cluster binding
HF197_RS06320	COG0493	'glutamate synthase
HF197_RS06360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HF197_RS06405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HF197_RS06415	COG4235	cytochrome complex assembly
HF197_RS06415	COG3088	subunit of a heme lyase
HF197_RS06455	COG0012	GTP binding
HF197_RS06515	COG0109	protoheme IX farnesyltransferase activity
HF197_RS06525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HF197_RS06535	COG1714	RDD family
HF197_RS06570	COG0305	Participates in initiation and elongation during chromosome replication
HF197_RS06600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HF197_RS06605	COG2814	Major facilitator Superfamily
HF197_RS06610	COG1253	flavin adenine dinucleotide binding
HF197_RS06625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HF197_RS06635	COG0590	tRNA wobble adenosine to inosine editing
HF197_RS06645	COG0504	CTP synthase activity
HF197_RS06655	COG2003	Belongs to the UPF0758 family
HF197_RS06670	COG0372	Belongs to the citrate synthase family
HF197_RS06675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HF197_RS06685	COG0739	heme binding
HF197_RS06695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HF197_RS06740	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HF197_RS06755	COG0194	GDP metabolic process
HF197_RS06760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HF197_RS06855	COG3344	reverse transcriptase
HF197_RS06900	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HF197_RS06935	COG0616	signal peptide processing
HF197_RS07035	COG3621	Patatin-like phospholipase
HF197_RS07105	COG2226	methyltransferase
HF197_RS07115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HF197_RS07125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HF197_RS07140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HF197_RS07150	COG0322	excinuclease ABC activity
HF197_RS07155	COG0751	glycine-tRNA ligase activity
HF197_RS07160	COG0752	glycyl-tRNA synthetase alpha subunit
HF197_RS07175	COG1230	cation diffusion facilitator family transporter
HF197_RS07180	COG1127	ABC transporter
HF197_RS07185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HF197_RS07190	COG1295	ribonuclease BN
HF197_RS07195	COG1028	Short-chain dehydrogenase reductase Sdr
HF197_RS07220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HF197_RS07260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HF197_RS07265	COG0359	binds to the 23S rRNA
HF197_RS07275	COG0360	Binds together with S18 to 16S ribosomal RNA
HF197_RS07295	COG1104	cysteine desulfurase activity
HF197_RS07310	COG0285	dihydrofolate synthase activity