locus-tag	class	description
GZ064_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GZ064_RS00100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GZ064_RS00115	COG0424	maF-like protein
GZ064_RS00125	COG1115	amino acid carrier protein
GZ064_RS00135	COG0459	protein refolding
GZ064_RS00140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GZ064_RS00160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GZ064_RS00175	COG2239	Acts as a magnesium transporter
GZ064_RS00195	COG0564	pseudouridine synthase activity
GZ064_RS00205	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GZ064_RS00225	COG1138	Cytochrome C-type biogenesis protein
GZ064_RS00235	COG2003	Belongs to the UPF0758 family
GZ064_RS00245	COG2003	Belongs to the UPF0758 family
GZ064_RS00255	COG1686	Belongs to the peptidase S11 family
GZ064_RS00260	COG1322	Protein conserved in bacteria
GZ064_RS00280	COG0653	protein targeting
GZ064_RS00290	COG2801	Transposase and inactivated derivatives
GZ064_RS00310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZ064_RS00320	COG2801	Transposase and inactivated derivatives
GZ064_RS00330	COG0626	cystathionine gamma-synthase activity
GZ064_RS00335	COG0271	Belongs to the BolA IbaG family
GZ064_RS00340	COG0443	Heat shock 70 kDa protein
GZ064_RS00345	COG1530	ribonuclease E activity
GZ064_RS00350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GZ064_RS00360	COG1121	(ABC) transporter
GZ064_RS00365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GZ064_RS00380	COG0450	alkyl hydroperoxide reductase
GZ064_RS00395	COG0450	alkyl hydroperoxide reductase
GZ064_RS00445	COG0805	protein transport
GZ064_RS00485	COG0617	tRNA 3'-terminal CCA addition
GZ064_RS00490	COG1217	gtp-binding protein TYPA
GZ064_RS00495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZ064_RS00495	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GZ064_RS00510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZ064_RS00525	COG1074	ATP-dependent DNA helicase activity
GZ064_RS00530	COG3088	subunit of a heme lyase
GZ064_RS00560	COG0358	DNA primase activity
GZ064_RS00565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GZ064_RS00585	COG0235	Class ii aldolase
GZ064_RS00600	COG2801	Transposase and inactivated derivatives
GZ064_RS00610	COG0484	heat shock protein binding
GZ064_RS00615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GZ064_RS00660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GZ064_RS00665	COG0148	phosphopyruvate hydratase activity
GZ064_RS00680	COG3346	SURF1 family
GZ064_RS00710	COG0114	fumarate hydratase activity
GZ064_RS00725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GZ064_RS00740	COG0484	heat shock protein binding
GZ064_RS00750	COG0823	Involved in the tonB-independent uptake of proteins
GZ064_RS00755	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZ064_RS00760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GZ064_RS00795	COG2801	Transposase and inactivated derivatives
GZ064_RS00815	COG3547	Transposase (IS116 IS110 IS902 family)
GZ064_RS00820	COG3328	transposase activity
GZ064_RS00890	COG3547	Transposase (IS116 IS110 IS902 family)
GZ064_RS01075	COG3621	Patatin-like phospholipase
GZ064_RS01090	COG2003	Belongs to the UPF0758 family
GZ064_RS01155	COG3328	transposase activity
GZ064_RS01255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZ064_RS01270	COG2801	Transposase and inactivated derivatives
GZ064_RS01290	COG3621	Patatin-like phospholipase
GZ064_RS01345	COG2003	Belongs to the UPF0758 family
GZ064_RS01395	COG3328	transposase activity
GZ064_RS01540	COG3547	Transposase (IS116 IS110 IS902 family)
GZ064_RS01550	COG1396	sequence-specific DNA binding
GZ064_RS01560	COG2003	Belongs to the UPF0758 family
GZ064_RS01570	COG3547	Transposase (IS116 IS110 IS902 family)
GZ064_RS01625	COG3547	Transposase (IS116 IS110 IS902 family)
GZ064_RS01640	COG2801	Transposase and inactivated derivatives
GZ064_RS01670	COG0012	GTP binding
GZ064_RS01680	COG1494	fructose-1,6-bisphosphatase
GZ064_RS01695	COG3842	ATPase activity
GZ064_RS01700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZ064_RS01705	COG2801	Transposase and inactivated derivatives
GZ064_RS01715	COG3932	Exopolysaccharide synthesis, ExoD
GZ064_RS01720	COG0215	cysteine-tRNA ligase activity
GZ064_RS01745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZ064_RS01750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GZ064_RS01755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZ064_RS01760	COG1981	membrane
GZ064_RS01765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GZ064_RS01770	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZ064_RS01775	COG4974	Belongs to the 'phage' integrase family
GZ064_RS01780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZ064_RS01795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZ064_RS01825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZ064_RS01830	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZ064_RS01865	COG3547	Transposase (IS116 IS110 IS902 family)
GZ064_RS01875	COG2801	Transposase and inactivated derivatives
GZ064_RS01885	COG0284	orotidine-5'-phosphate decarboxylase activity
GZ064_RS01895	COG2801	Transposase and inactivated derivatives
GZ064_RS01905	COG2801	Transposase and inactivated derivatives
GZ064_RS01915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GZ064_RS01930	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GZ064_RS01950	COG0736	holo-[acyl-carrier-protein] synthase activity
GZ064_RS01955	COG2801	Transposase and inactivated derivatives
GZ064_RS02010	COG3577	Aspartyl protease
GZ064_RS02105	COG2003	Belongs to the UPF0758 family
GZ064_RS02140	COG2801	Transposase and inactivated derivatives
GZ064_RS02165	COG3621	Patatin-like phospholipase
GZ064_RS02180	COG2003	Belongs to the UPF0758 family
GZ064_RS02235	COG2801	Transposase and inactivated derivatives
GZ064_RS02270	COG3547	Transposase (IS116 IS110 IS902 family)
GZ064_RS02355	COG4804	nuclease activity
GZ064_RS02365	COG2801	Transposase and inactivated derivatives
GZ064_RS02375	COG1396	sequence-specific DNA binding
GZ064_RS02385	COG2003	Belongs to the UPF0758 family
GZ064_RS02415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZ064_RS02430	COG1381	Involved in DNA repair and RecF pathway recombination
GZ064_RS02445	COG2902	Dehydrogenase
GZ064_RS02450	COG0542	response to heat
GZ064_RS02465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZ064_RS02490	COG0237	dephospho-CoA kinase activity
GZ064_RS02495	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GZ064_RS02510	COG1714	RDD family
GZ064_RS02520	COG0305	Participates in initiation and elongation during chromosome replication
GZ064_RS02540	COG0196	riboflavin kinase activity
GZ064_RS02545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GZ064_RS02550	COG0612	Peptidase, M16
GZ064_RS02585	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GZ064_RS02605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GZ064_RS02610	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GZ064_RS02620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GZ064_RS02625	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GZ064_RS02655	COG0567	Dehydrogenase, E1 component
GZ064_RS02690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GZ064_RS02695	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GZ064_RS02720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GZ064_RS02745	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GZ064_RS02755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GZ064_RS02760	COG0254	rRNA binding
GZ064_RS02765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GZ064_RS02775	COG1840	ABC-type Fe3 transport system, periplasmic component
GZ064_RS02780	COG0540	Belongs to the ATCase OTCase family
GZ064_RS02795	COG0194	GDP metabolic process
GZ064_RS02805	COG1053	succinate dehydrogenase
GZ064_RS02820	COG2171	N-acyltransferase activity
GZ064_RS02845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GZ064_RS02850	COG0612	Peptidase, M16
GZ064_RS02860	COG0343	queuine tRNA-ribosyltransferase activity
GZ064_RS02865	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GZ064_RS02880	COG0666	response to abiotic stimulus
GZ064_RS02895	COG0745	RESPONSE REGULATOR receiver
GZ064_RS02900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GZ064_RS02905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GZ064_RS02920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GZ064_RS02925	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GZ064_RS02945	COG0606	chelatase, subunit chli
GZ064_RS02950	COG0726	polysaccharide deacetylase
GZ064_RS02955	COG0768	penicillin binding
GZ064_RS02960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GZ064_RS02965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GZ064_RS02970	COG0740	serine-type endopeptidase activity
GZ064_RS02975	COG0544	peptidyl-prolyl cis-trans isomerase activity
GZ064_RS02995	COG2890	protein-(glutamine-N5) methyltransferase activity
GZ064_RS02995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GZ064_RS03005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GZ064_RS03010	COG0049	tRNA binding
GZ064_RS03015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GZ064_RS03020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GZ064_RS03035	COG0250	Participates in transcription elongation, termination and antitermination
GZ064_RS03040	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GZ064_RS03045	COG0081	regulation of translation
GZ064_RS03050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GZ064_RS03055	COG0222	ribosome binding
GZ064_RS03060	COG0085	RNA polymerase activity
GZ064_RS03060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GZ064_RS03065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZ064_RS03075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GZ064_RS03095	COG0473	3-isopropylmalate dehydrogenase activity
GZ064_RS03115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GZ064_RS03130	COG0742	ribosomal rna small subunit methyltransferase
GZ064_RS03145	COG3704	protein secretion by the type IV secretion system
GZ064_RS03145	COG1340	protein secretion by the type IV secretion system
GZ064_RS03150	COG3704	protein secretion by the type IV secretion system
GZ064_RS03155	COG3704	protein secretion by the type IV secretion system
GZ064_RS03160	COG3451	type IV secretory pathway VirB4
GZ064_RS03170	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GZ064_RS03205	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GZ064_RS03210	COG3827	peptidoglycan binding
GZ064_RS03220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GZ064_RS03235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GZ064_RS03240	COG0071	Belongs to the small heat shock protein (HSP20) family
GZ064_RS03245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZ064_RS03255	COG4770	biotin carboxylase activity
GZ064_RS03260	COG1612	heme a metabolic process
GZ064_RS03265	COG1215	transferase activity, transferring glycosyl groups
GZ064_RS03280	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZ064_RS03285	COG0356	it plays a direct role in the translocation of protons across the membrane
GZ064_RS03295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZ064_RS03295	COG0072	phenylalanine-tRNA ligase activity
GZ064_RS03300	COG3328	transposase activity
GZ064_RS03310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GZ064_RS03355	COG0649	NAD binding
GZ064_RS03370	COG2070	2-Nitropropane dioxygenase
GZ064_RS03385	COG3451	type IV secretory pathway VirB4
GZ064_RS03395	COG3328	transposase activity
GZ064_RS03400	COG0666	response to abiotic stimulus
GZ064_RS03420	COG0006	proline dipeptidase activity
GZ064_RS03425	COG0445	tRNA wobble uridine modification
GZ064_RS03440	COG0728	peptidoglycan biosynthetic process
GZ064_RS03450	COG2801	Transposase and inactivated derivatives
GZ064_RS03465	COG4695	Portal protein
GZ064_RS03485	COG0321	lipoyl(octanoyl) transferase activity
GZ064_RS03490	COG1619	proteins homologs of microcin C7 resistance protein MccF
GZ064_RS03500	COG0360	Binds together with S18 to 16S ribosomal RNA
GZ064_RS03510	COG0359	binds to the 23S rRNA
GZ064_RS03515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GZ064_RS03530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZ064_RS03575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GZ064_RS03575	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GZ064_RS03585	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GZ064_RS03625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GZ064_RS03675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZ064_RS03690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GZ064_RS03700	COG1301	dicarboxylic acid transport
GZ064_RS03705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GZ064_RS03725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GZ064_RS03780	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZ064_RS03800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GZ064_RS03810	COG2205	protein histidine kinase activity
GZ064_RS03815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZ064_RS03825	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GZ064_RS03830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GZ064_RS03840	COG0156	8-amino-7-oxononanoate synthase activity
GZ064_RS03850	COG0326	Molecular chaperone. Has ATPase activity
GZ064_RS03860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GZ064_RS03885	COG0666	response to abiotic stimulus
GZ064_RS03895	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GZ064_RS03900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZ064_RS03910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZ064_RS03915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZ064_RS03920	COG0142	geranyltranstransferase activity
GZ064_RS03930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GZ064_RS03935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GZ064_RS03950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GZ064_RS03960	COG0105	UTP biosynthetic process
GZ064_RS03965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZ064_RS03970	COG4536	flavin adenine dinucleotide binding
GZ064_RS03975	COG3750	Belongs to the UPF0335 family
GZ064_RS03980	COG0163	prenyltransferase activity
GZ064_RS03985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GZ064_RS04000	COG0495	leucyl-tRNA aminoacylation
GZ064_RS04015	COG0776	regulation of translation
GZ064_RS04025	COG0556	nucleotide-excision repair
GZ064_RS04030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GZ064_RS04030	COG2857	Cytochrome c1
GZ064_RS04035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GZ064_RS04065	COG0484	heat shock protein binding
GZ064_RS04075	COG0124	histidyl-tRNA synthetase
GZ064_RS04080	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GZ064_RS04090	COG0531	amino acid
GZ064_RS04095	COG1113	amino acid transport
GZ064_RS04105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GZ064_RS04110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GZ064_RS04120	COG1178	ABC-type Fe3 transport system permease component
GZ064_RS04125	COG1054	Belongs to the UPF0176 family
GZ064_RS04150	COG0493	'glutamate synthase
GZ064_RS04150	COG0543	2 iron, 2 sulfur cluster binding
GZ064_RS04155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZ064_RS04165	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GZ064_RS04220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GZ064_RS04230	COG0482	sulfurtransferase activity
GZ064_RS04245	COG2885	chlorophyll binding
GZ064_RS04250	COG0037	tRNA processing
GZ064_RS04255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZ064_RS04270	COG3335	DDE superfamily endonuclease
GZ064_RS04280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GZ064_RS04290	COG0275	rRNA processing
GZ064_RS04295	COG0477	Major facilitator Superfamily
GZ064_RS04300	COG0024	Methionine aminopeptidase
GZ064_RS04305	COG0849	cell division
GZ064_RS04335	COG1573	uracil-dna glycosylase
GZ064_RS04345	COG0849	cell division
GZ064_RS04350	COG0849	cell division
GZ064_RS04355	COG0242	peptide deformylase activity
GZ064_RS04360	COG1573	uracil-dna glycosylase
GZ064_RS04365	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GZ064_RS04375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GZ064_RS04390	COG1295	ribonuclease BN
GZ064_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
GZ064_RS04400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GZ064_RS04405	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GZ064_RS04410	COG0101	tRNA pseudouridine synthase activity
GZ064_RS04425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GZ064_RS04435	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GZ064_RS04440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GZ064_RS04470	COG2867	negative regulation of translational initiation
GZ064_RS04485	COG0285	dihydrofolate synthase activity
GZ064_RS04505	COG0312	modulator of DNA gyrase
GZ064_RS04525	COG3328	transposase activity
GZ064_RS04530	COG0564	pseudouridine synthase activity
GZ064_RS04550	COG2333	competence protein COMEC
GZ064_RS04550	COG0658	competence protein
GZ064_RS04565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GZ064_RS04585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GZ064_RS04590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GZ064_RS04600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GZ064_RS04610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZ064_RS04635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GZ064_RS04655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GZ064_RS04660	COG0259	pyridoxamine-phosphate oxidase activity
GZ064_RS04690	COG0047	phosphoribosylformylglycinamidine synthase activity
GZ064_RS04695	COG0581	inorganic phosphate transmembrane transporter activity
GZ064_RS04700	COG0335	large ribosomal subunit rRNA binding
GZ064_RS04745	COG0335	large ribosomal subunit rRNA binding
GZ064_RS04750	COG0336	Belongs to the RNA methyltransferase TrmD family
GZ064_RS04755	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GZ064_RS04760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GZ064_RS04775	COG1253	flavin adenine dinucleotide binding
GZ064_RS04780	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GZ064_RS04785	COG0436	Aminotransferase
GZ064_RS04805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GZ064_RS04810	COG0126	phosphoglycerate kinase activity
GZ064_RS04825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GZ064_RS04830	COG1185	polyribonucleotide nucleotidyltransferase activity
GZ064_RS04835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GZ064_RS04840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GZ064_RS04850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZ064_RS04850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZ064_RS04855	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GZ064_RS04860	COG0316	Belongs to the HesB IscA family
GZ064_RS04870	COG2945	thiolester hydrolase activity
GZ064_RS04875	COG1104	cysteine desulfurase activity
GZ064_RS04880	COG0670	Belongs to the BI1 family
GZ064_RS04885	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GZ064_RS04905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZ064_RS04910	COG0629	single-stranded DNA binding
GZ064_RS04935	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GZ064_RS04945	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GZ064_RS04960	COG0723	plastoquinol--plastocyanin reductase activity
GZ064_RS04985	COG1268	BioY protein
GZ064_RS05010	COG0045	succinate-CoA ligase (ADP-forming) activity
GZ064_RS05025	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GZ064_RS05060	COG1475	DNA binding
GZ064_RS05065	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GZ064_RS05065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GZ064_RS05075	COG0628	permease
GZ064_RS05085	COG4974	Belongs to the 'phage' integrase family
GZ064_RS05100	COG0372	Belongs to the citrate synthase family
GZ064_RS05165	COG0651	ATP synthesis coupled electron transport
GZ064_RS05170	COG0772	Belongs to the SEDS family
GZ064_RS05175	COG1104	cysteine desulfurase activity
GZ064_RS05185	COG3547	Transposase (IS116 IS110 IS902 family)
GZ064_RS05200	COG0492	ferredoxin-NADP+ reductase activity
GZ064_RS05215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZ064_RS05220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZ064_RS05225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GZ064_RS05230	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GZ064_RS05260	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GZ064_RS05270	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GZ064_RS05270	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GZ064_RS05275	COG1007	ATP synthesis coupled electron transport
GZ064_RS05280	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZ064_RS05285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GZ064_RS05290	COG0713	ATP synthesis coupled electron transport
GZ064_RS05295	COG0839	Belongs to the complex I subunit 6 family
GZ064_RS05315	COG3474	cytochrome
GZ064_RS05320	COG0632	four-way junction helicase activity
GZ064_RS05325	COG2255	four-way junction helicase activity
GZ064_RS05330	COG2255	four-way junction helicase activity
GZ064_RS05335	COG0632	four-way junction helicase activity
GZ064_RS05385	COG2827	Endonuclease containing a URI domain
GZ064_RS05395	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GZ064_RS05405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GZ064_RS05420	COG2094	Belongs to the DNA glycosylase MPG family
GZ064_RS05455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GZ064_RS05460	COG0799	negative regulation of ribosome biogenesis
GZ064_RS05470	COG0494	nUDIX hydrolase
GZ064_RS05475	COG0084	hydrolase, TatD family'
GZ064_RS05480	COG0039	L-malate dehydrogenase activity
GZ064_RS05485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZ064_RS05490	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZ064_RS05495	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZ064_RS05500	COG0537	adenosine 5'-monophosphoramidase activity
GZ064_RS05520	COG1090	epimerase
GZ064_RS05530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZ064_RS05535	COG0416	fatty acid biosynthetic process
GZ064_RS05540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GZ064_RS05545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GZ064_RS05550	COG4175	Glycine betaine
GZ064_RS05555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GZ064_RS05575	COG0543	2 iron, 2 sulfur cluster binding
GZ064_RS05575	COG0493	'glutamate synthase
GZ064_RS05595	COG0750	zinc metalloprotease
GZ064_RS05610	COG0776	regulation of translation
GZ064_RS05615	COG0539	negative regulation of cytoplasmic translation
GZ064_RS05620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GZ064_RS05640	COG3328	transposase activity
GZ064_RS05675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GZ064_RS05680	COG1006	Multisubunit Na H antiporter MnhC subunit
GZ064_RS05695	COG1320	monovalent cation:proton antiporter activity
GZ064_RS05705	COG1758	RNA polymerase activity
GZ064_RS05715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GZ064_RS05730	COG0330	HflC and HflK could
GZ064_RS05760	COG2009	succinate dehydrogenase
GZ064_RS05765	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GZ064_RS05780	COG4591	ABC-type transport system involved in lipoprotein release permease component
GZ064_RS05795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GZ064_RS05800	COG0312	modulator of DNA gyrase
GZ064_RS05805	COG1278	Cold shock
GZ064_RS05810	COG0513	Belongs to the DEAD box helicase family
GZ064_RS05825	COG1830	Aldolase
GZ064_RS05840	COG0167	dihydroorotate dehydrogenase activity
GZ064_RS05845	COG0571	ribonuclease III activity
GZ064_RS05850	COG1999	signal sequence binding
GZ064_RS05855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GZ064_RS05865	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GZ064_RS05870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GZ064_RS05885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GZ064_RS05895	COG1034	ATP synthesis coupled electron transport
GZ064_RS05900	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GZ064_RS05905	COG0113	porphobilinogen synthase activity
GZ064_RS05920	COG0752	glycyl-tRNA synthetase alpha subunit
GZ064_RS05925	COG0751	glycine-tRNA ligase activity
GZ064_RS05930	COG0322	excinuclease ABC activity
GZ064_RS05940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZ064_RS05960	COG1230	cation diffusion facilitator family transporter
GZ064_RS05970	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GZ064_RS05975	COG1115	amino acid carrier protein
GZ064_RS05980	COG1115	amino acid carrier protein
GZ064_RS05985	COG1183	phosphatidylcholine synthase activity
GZ064_RS06010	COG0187	DNA topoisomerase II activity
GZ064_RS06015	COG0154	amidase activity
GZ064_RS06020	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZ064_RS06020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZ064_RS06050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZ064_RS06060	COG0307	riboflavin synthase, alpha
GZ064_RS06070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GZ064_RS06075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GZ064_RS06095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GZ064_RS06100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GZ064_RS06110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GZ064_RS06115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GZ064_RS06125	COG1845	cytochrome c oxidase, subunit III
GZ064_RS06140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GZ064_RS06140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZ064_RS06170	COG0594	ribonuclease P activity
GZ064_RS06175	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GZ064_RS06180	COG0573	inorganic phosphate transmembrane transporter activity
GZ064_RS06185	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GZ064_RS06190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GZ064_RS06225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GZ064_RS06230	COG0051	transcription antitermination factor activity, RNA binding
GZ064_RS06235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GZ064_RS06240	COG0088	Forms part of the polypeptide exit tunnel
GZ064_RS06250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GZ064_RS06255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GZ064_RS06260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GZ064_RS06265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GZ064_RS06270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GZ064_RS06275	COG0255	Belongs to the universal ribosomal protein uL29 family
GZ064_RS06285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GZ064_RS06290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GZ064_RS06300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GZ064_RS06310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GZ064_RS06315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GZ064_RS06320	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GZ064_RS06325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GZ064_RS06330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GZ064_RS06335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GZ064_RS06340	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GZ064_RS06345	COG0200	Binds to the 23S rRNA
GZ064_RS06350	COG0201	protein transport
GZ064_RS06355	COG0563	adenylate kinase activity
GZ064_RS06360	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GZ064_RS06365	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GZ064_RS06370	COG0202	RNA polymerase activity
GZ064_RS06375	COG0203	ribosomal protein L17
GZ064_RS06380	COG0792	nuclease activity
GZ064_RS06385	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZ064_RS06390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GZ064_RS06395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZ064_RS06425	COG0574	Belongs to the PEP-utilizing enzyme family
GZ064_RS06425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZ064_RS06440	COG1566	PFAM secretion protein HlyD family protein
GZ064_RS06445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GZ064_RS06455	COG0280	phosphate acetyltransferase
GZ064_RS06455	COG0281	malic enzyme
GZ064_RS06460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GZ064_RS06475	COG0217	transcriptional regulatory protein
GZ064_RS06480	COG0739	heme binding
GZ064_RS06510	COG2814	Major facilitator Superfamily
GZ064_RS06515	COG2226	methyltransferase
GZ064_RS06520	COG1132	(ABC) transporter
GZ064_RS06530	COG0018	arginyl-trna synthetase
GZ064_RS06535	COG4133	protoheme IX ABC transporter activity
GZ064_RS06545	COG0590	tRNA wobble adenosine to inosine editing
GZ064_RS06555	COG0504	CTP synthase activity
GZ064_RS06565	COG4451	ribulose bisphosphate carboxylase, small
GZ064_RS06565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GZ064_RS06590	COG1862	Preprotein translocase
GZ064_RS06600	COG0052	Belongs to the universal ribosomal protein uS2 family
GZ064_RS06605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GZ064_RS06610	COG0528	UMP kinase activity
GZ064_RS06615	COG0233	cytoplasmic translational termination
GZ064_RS06635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZ064_RS06640	COG0717	Belongs to the dCTP deaminase family
GZ064_RS06665	COG3736	Type IV secretory pathway, component VirB8
GZ064_RS06680	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
GZ064_RS06695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZ064_RS06700	COG0477	Major facilitator Superfamily
GZ064_RS06705	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GZ064_RS06710	COG0552	protein localization to endoplasmic reticulum
GZ064_RS06715	COG0822	iron-sulfur transferase activity
GZ064_RS06720	COG0316	Belongs to the HesB IscA family
GZ064_RS06725	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GZ064_RS06735	COG0681	Belongs to the peptidase S26 family
GZ064_RS06745	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZ064_RS06745	COG0022	dehydrogenase e1 component
GZ064_RS06760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GZ064_RS06780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZ064_RS06810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GZ064_RS06820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GZ064_RS06825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GZ064_RS06845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GZ064_RS06850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GZ064_RS06965	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GZ064_RS06990	COG4804	nuclease activity
GZ064_RS07025	COG3547	Transposase (IS116 IS110 IS902 family)
GZ064_RS07060	COG3328	transposase activity
GZ064_RS07065	COG3547	Transposase (IS116 IS110 IS902 family)
GZ064_RS07220	COG2801	Transposase and inactivated derivatives
GZ064_RS07225	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GZ064_RS07230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GZ064_RS07235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GZ064_RS07245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZ064_RS07255	COG0174	glutamine synthetase