locus-tag	class	description
GZ065_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GZ065_RS00095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GZ065_RS00110	COG0424	maF-like protein
GZ065_RS00120	COG1115	amino acid carrier protein
GZ065_RS00130	COG0459	protein refolding
GZ065_RS00135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GZ065_RS00155	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GZ065_RS00170	COG2239	Acts as a magnesium transporter
GZ065_RS00190	COG0564	pseudouridine synthase activity
GZ065_RS00200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GZ065_RS00220	COG1138	Cytochrome C-type biogenesis protein
GZ065_RS00230	COG2003	Belongs to the UPF0758 family
GZ065_RS00240	COG2003	Belongs to the UPF0758 family
GZ065_RS00250	COG1686	Belongs to the peptidase S11 family
GZ065_RS00255	COG1322	Protein conserved in bacteria
GZ065_RS00275	COG0653	protein targeting
GZ065_RS00285	COG2801	Transposase and inactivated derivatives
GZ065_RS00305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZ065_RS00315	COG2801	Transposase and inactivated derivatives
GZ065_RS00325	COG0626	cystathionine gamma-synthase activity
GZ065_RS00330	COG0271	Belongs to the BolA IbaG family
GZ065_RS00335	COG0443	Heat shock 70 kDa protein
GZ065_RS00350	COG0443	Heat shock 70 kDa protein
GZ065_RS00360	COG0443	Heat shock 70 kDa protein
GZ065_RS00370	COG0443	Heat shock 70 kDa protein
GZ065_RS00375	COG0271	Belongs to the BolA IbaG family
GZ065_RS00410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GZ065_RS00425	COG1530	ribonuclease E activity
GZ065_RS00430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GZ065_RS00440	COG1121	(ABC) transporter
GZ065_RS00445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GZ065_RS00460	COG0450	alkyl hydroperoxide reductase
GZ065_RS00480	COG0805	protein transport
GZ065_RS00520	COG0617	tRNA 3'-terminal CCA addition
GZ065_RS00525	COG1217	gtp-binding protein TYPA
GZ065_RS00530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZ065_RS00530	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GZ065_RS00545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZ065_RS00560	COG1074	ATP-dependent DNA helicase activity
GZ065_RS00565	COG3088	subunit of a heme lyase
GZ065_RS00595	COG0358	DNA primase activity
GZ065_RS00600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GZ065_RS00620	COG0235	Class ii aldolase
GZ065_RS00635	COG2801	Transposase and inactivated derivatives
GZ065_RS00645	COG0484	heat shock protein binding
GZ065_RS00650	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GZ065_RS00695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GZ065_RS00700	COG0148	phosphopyruvate hydratase activity
GZ065_RS00715	COG3346	SURF1 family
GZ065_RS00745	COG0114	fumarate hydratase activity
GZ065_RS00760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GZ065_RS00775	COG0484	heat shock protein binding
GZ065_RS00785	COG0823	Involved in the tonB-independent uptake of proteins
GZ065_RS00790	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZ065_RS00795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GZ065_RS00830	COG2801	Transposase and inactivated derivatives
GZ065_RS00850	COG3547	Transposase (IS116 IS110 IS902 family)
GZ065_RS00855	COG3328	transposase activity
GZ065_RS00925	COG3547	Transposase (IS116 IS110 IS902 family)
GZ065_RS01110	COG3621	Patatin-like phospholipase
GZ065_RS01125	COG2003	Belongs to the UPF0758 family
GZ065_RS01190	COG3328	transposase activity
GZ065_RS01195	COG3328	transposase activity
GZ065_RS01335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GZ065_RS01350	COG2801	Transposase and inactivated derivatives
GZ065_RS01370	COG3621	Patatin-like phospholipase
GZ065_RS01450	COG2003	Belongs to the UPF0758 family
GZ065_RS01525	COG0590	tRNA wobble adenosine to inosine editing
GZ065_RS01560	COG3328	transposase activity
GZ065_RS01700	COG3547	Transposase (IS116 IS110 IS902 family)
GZ065_RS01710	COG1396	sequence-specific DNA binding
GZ065_RS01720	COG2003	Belongs to the UPF0758 family
GZ065_RS01730	COG3547	Transposase (IS116 IS110 IS902 family)
GZ065_RS01785	COG3547	Transposase (IS116 IS110 IS902 family)
GZ065_RS01800	COG2801	Transposase and inactivated derivatives
GZ065_RS01830	COG0012	GTP binding
GZ065_RS01840	COG1494	fructose-1,6-bisphosphatase
GZ065_RS01855	COG3842	ATPase activity
GZ065_RS01860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZ065_RS01865	COG2801	Transposase and inactivated derivatives
GZ065_RS01875	COG3932	Exopolysaccharide synthesis, ExoD
GZ065_RS01880	COG0215	cysteine-tRNA ligase activity
GZ065_RS01900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZ065_RS01905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GZ065_RS01910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GZ065_RS01915	COG1981	membrane
GZ065_RS01920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GZ065_RS01925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZ065_RS01930	COG4974	Belongs to the 'phage' integrase family
GZ065_RS01935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZ065_RS01950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GZ065_RS01960	COG0525	valine-tRNA ligase activity
GZ065_RS01970	COG3547	Transposase (IS116 IS110 IS902 family)
GZ065_RS01980	COG2801	Transposase and inactivated derivatives
GZ065_RS01990	COG0284	orotidine-5'-phosphate decarboxylase activity
GZ065_RS02000	COG2801	Transposase and inactivated derivatives
GZ065_RS02010	COG2801	Transposase and inactivated derivatives
GZ065_RS02020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GZ065_RS02035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GZ065_RS02055	COG0736	holo-[acyl-carrier-protein] synthase activity
GZ065_RS02060	COG2801	Transposase and inactivated derivatives
GZ065_RS02115	COG3577	Aspartyl protease
GZ065_RS02210	COG2003	Belongs to the UPF0758 family
GZ065_RS02245	COG2801	Transposase and inactivated derivatives
GZ065_RS02270	COG3621	Patatin-like phospholipase
GZ065_RS02285	COG2003	Belongs to the UPF0758 family
GZ065_RS02340	COG2801	Transposase and inactivated derivatives
GZ065_RS02375	COG3547	Transposase (IS116 IS110 IS902 family)
GZ065_RS02460	COG4804	nuclease activity
GZ065_RS02470	COG2801	Transposase and inactivated derivatives
GZ065_RS02480	COG1396	sequence-specific DNA binding
GZ065_RS02490	COG2003	Belongs to the UPF0758 family
GZ065_RS02520	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZ065_RS02535	COG1381	Involved in DNA repair and RecF pathway recombination
GZ065_RS02550	COG2902	Dehydrogenase
GZ065_RS02555	COG0542	response to heat
GZ065_RS02570	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZ065_RS02595	COG0237	dephospho-CoA kinase activity
GZ065_RS02600	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GZ065_RS02615	COG1714	RDD family
GZ065_RS02625	COG0305	Participates in initiation and elongation during chromosome replication
GZ065_RS02645	COG0196	riboflavin kinase activity
GZ065_RS02650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GZ065_RS02655	COG0612	Peptidase, M16
GZ065_RS02690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GZ065_RS02710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GZ065_RS02715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GZ065_RS02725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GZ065_RS02730	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GZ065_RS02760	COG0567	Dehydrogenase, E1 component
GZ065_RS02795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GZ065_RS02800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GZ065_RS02825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GZ065_RS02850	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GZ065_RS02860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GZ065_RS02865	COG0254	rRNA binding
GZ065_RS02870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GZ065_RS02880	COG1840	ABC-type Fe3 transport system, periplasmic component
GZ065_RS02885	COG0540	Belongs to the ATCase OTCase family
GZ065_RS02900	COG0194	GDP metabolic process
GZ065_RS02910	COG1053	succinate dehydrogenase
GZ065_RS02925	COG2171	N-acyltransferase activity
GZ065_RS02950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GZ065_RS02955	COG0612	Peptidase, M16
GZ065_RS02965	COG0343	queuine tRNA-ribosyltransferase activity
GZ065_RS02970	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GZ065_RS02985	COG0666	response to abiotic stimulus
GZ065_RS03000	COG0745	RESPONSE REGULATOR receiver
GZ065_RS03005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GZ065_RS03010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GZ065_RS03025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GZ065_RS03030	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GZ065_RS03050	COG0606	chelatase, subunit chli
GZ065_RS03055	COG0726	polysaccharide deacetylase
GZ065_RS03060	COG0768	penicillin binding
GZ065_RS03065	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GZ065_RS03070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GZ065_RS03075	COG0740	serine-type endopeptidase activity
GZ065_RS03080	COG0544	peptidyl-prolyl cis-trans isomerase activity
GZ065_RS03105	COG2890	protein-(glutamine-N5) methyltransferase activity
GZ065_RS03105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GZ065_RS03115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GZ065_RS03120	COG0049	tRNA binding
GZ065_RS03125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GZ065_RS03130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GZ065_RS03145	COG0250	Participates in transcription elongation, termination and antitermination
GZ065_RS03150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GZ065_RS03155	COG0081	regulation of translation
GZ065_RS03160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GZ065_RS03165	COG0222	ribosome binding
GZ065_RS03170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GZ065_RS03170	COG0085	RNA polymerase activity
GZ065_RS03175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZ065_RS03200	COG0085	RNA polymerase activity
GZ065_RS03200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GZ065_RS03205	COG0085	RNA polymerase activity
GZ065_RS03205	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GZ065_RS03210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GZ065_RS03210	COG0085	RNA polymerase activity
GZ065_RS03225	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GZ065_RS03245	COG0473	3-isopropylmalate dehydrogenase activity
GZ065_RS03265	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GZ065_RS03280	COG0742	ribosomal rna small subunit methyltransferase
GZ065_RS03295	COG1340	protein secretion by the type IV secretion system
GZ065_RS03295	COG3704	protein secretion by the type IV secretion system
GZ065_RS03300	COG3704	protein secretion by the type IV secretion system
GZ065_RS03305	COG3704	protein secretion by the type IV secretion system
GZ065_RS03310	COG3451	type IV secretory pathway VirB4
GZ065_RS03320	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
GZ065_RS03355	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GZ065_RS03360	COG3827	peptidoglycan binding
GZ065_RS03370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GZ065_RS03385	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GZ065_RS03390	COG0071	Belongs to the small heat shock protein (HSP20) family
GZ065_RS03395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZ065_RS03405	COG4770	biotin carboxylase activity
GZ065_RS03410	COG1612	heme a metabolic process
GZ065_RS03415	COG1215	transferase activity, transferring glycosyl groups
GZ065_RS03430	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZ065_RS03435	COG0356	it plays a direct role in the translocation of protons across the membrane
GZ065_RS03445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZ065_RS03445	COG0072	phenylalanine-tRNA ligase activity
GZ065_RS03450	COG3328	transposase activity
GZ065_RS03460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GZ065_RS03465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZ065_RS03480	COG0649	NAD binding
GZ065_RS03495	COG2070	2-Nitropropane dioxygenase
GZ065_RS03510	COG3451	type IV secretory pathway VirB4
GZ065_RS03520	COG3328	transposase activity
GZ065_RS03525	COG0666	response to abiotic stimulus
GZ065_RS03545	COG0006	proline dipeptidase activity
GZ065_RS03550	COG0445	tRNA wobble uridine modification
GZ065_RS03565	COG0728	peptidoglycan biosynthetic process
GZ065_RS03575	COG2801	Transposase and inactivated derivatives
GZ065_RS03590	COG4695	Portal protein
GZ065_RS03610	COG0321	lipoyl(octanoyl) transferase activity
GZ065_RS03615	COG1619	proteins homologs of microcin C7 resistance protein MccF
GZ065_RS03625	COG0360	Binds together with S18 to 16S ribosomal RNA
GZ065_RS03635	COG0359	binds to the 23S rRNA
GZ065_RS03640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GZ065_RS03655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZ065_RS03700	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GZ065_RS03700	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GZ065_RS03710	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GZ065_RS03750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GZ065_RS03795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZ065_RS03810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GZ065_RS03820	COG1301	dicarboxylic acid transport
GZ065_RS03825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GZ065_RS03845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GZ065_RS03900	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZ065_RS03920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GZ065_RS03930	COG2205	protein histidine kinase activity
GZ065_RS03935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZ065_RS03945	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GZ065_RS03950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GZ065_RS03960	COG0156	8-amino-7-oxononanoate synthase activity
GZ065_RS03970	COG0326	Molecular chaperone. Has ATPase activity
GZ065_RS03980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GZ065_RS04005	COG0666	response to abiotic stimulus
GZ065_RS04015	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GZ065_RS04020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZ065_RS04030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GZ065_RS04035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZ065_RS04040	COG0142	geranyltranstransferase activity
GZ065_RS04050	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GZ065_RS04055	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GZ065_RS04070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GZ065_RS04080	COG0105	UTP biosynthetic process
GZ065_RS04085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GZ065_RS04090	COG4536	flavin adenine dinucleotide binding
GZ065_RS04095	COG3750	Belongs to the UPF0335 family
GZ065_RS04100	COG0163	prenyltransferase activity
GZ065_RS04105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GZ065_RS04120	COG0495	leucyl-tRNA aminoacylation
GZ065_RS04135	COG0776	regulation of translation
GZ065_RS04145	COG0556	nucleotide-excision repair
GZ065_RS04150	COG2857	Cytochrome c1
GZ065_RS04150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GZ065_RS04155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GZ065_RS04185	COG0484	heat shock protein binding
GZ065_RS04195	COG0124	histidyl-tRNA synthetase
GZ065_RS04200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GZ065_RS04210	COG0531	amino acid
GZ065_RS04215	COG1113	amino acid transport
GZ065_RS04225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GZ065_RS04230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GZ065_RS04280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GZ065_RS04290	COG1178	ABC-type Fe3 transport system permease component
GZ065_RS04295	COG1054	Belongs to the UPF0176 family
GZ065_RS04320	COG0493	'glutamate synthase
GZ065_RS04320	COG0543	2 iron, 2 sulfur cluster binding
GZ065_RS04325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZ065_RS04335	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GZ065_RS04345	COG0482	sulfurtransferase activity
GZ065_RS04360	COG2885	chlorophyll binding
GZ065_RS04365	COG0037	tRNA processing
GZ065_RS04370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZ065_RS04385	COG3335	DDE superfamily endonuclease
GZ065_RS04395	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GZ065_RS04405	COG0275	rRNA processing
GZ065_RS04410	COG0477	Major facilitator Superfamily
GZ065_RS04415	COG0024	Methionine aminopeptidase
GZ065_RS04420	COG0849	cell division
GZ065_RS04425	COG0242	peptide deformylase activity
GZ065_RS04430	COG1573	uracil-dna glycosylase
GZ065_RS04435	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
GZ065_RS04450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GZ065_RS04465	COG1295	ribonuclease BN
GZ065_RS04470	COG1028	Short-chain dehydrogenase reductase Sdr
GZ065_RS04475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GZ065_RS04480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GZ065_RS04485	COG0101	tRNA pseudouridine synthase activity
GZ065_RS04500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GZ065_RS04510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GZ065_RS04515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GZ065_RS04545	COG2867	negative regulation of translational initiation
GZ065_RS04560	COG0285	dihydrofolate synthase activity
GZ065_RS04580	COG0312	modulator of DNA gyrase
GZ065_RS04600	COG3328	transposase activity
GZ065_RS04605	COG0564	pseudouridine synthase activity
GZ065_RS04625	COG2333	competence protein COMEC
GZ065_RS04625	COG0658	competence protein
GZ065_RS04635	COG0527	aspartate kinase activity
GZ065_RS04690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GZ065_RS04710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GZ065_RS04715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GZ065_RS04725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GZ065_RS04735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZ065_RS04760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GZ065_RS04780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GZ065_RS04785	COG0259	pyridoxamine-phosphate oxidase activity
GZ065_RS04815	COG0047	phosphoribosylformylglycinamidine synthase activity
GZ065_RS04820	COG0581	inorganic phosphate transmembrane transporter activity
GZ065_RS04825	COG0335	large ribosomal subunit rRNA binding
GZ065_RS04840	COG0573	inorganic phosphate transmembrane transporter activity
GZ065_RS04885	COG0335	large ribosomal subunit rRNA binding
GZ065_RS04890	COG0336	Belongs to the RNA methyltransferase TrmD family
GZ065_RS04895	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GZ065_RS04900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GZ065_RS04915	COG1253	flavin adenine dinucleotide binding
GZ065_RS04920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GZ065_RS04925	COG0436	Aminotransferase
GZ065_RS04945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GZ065_RS04950	COG0126	phosphoglycerate kinase activity
GZ065_RS04965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GZ065_RS04970	COG1185	polyribonucleotide nucleotidyltransferase activity
GZ065_RS04975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GZ065_RS04980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GZ065_RS04990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZ065_RS04990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZ065_RS04995	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GZ065_RS05000	COG0316	Belongs to the HesB IscA family
GZ065_RS05010	COG2945	thiolester hydrolase activity
GZ065_RS05015	COG1104	cysteine desulfurase activity
GZ065_RS05020	COG0670	Belongs to the BI1 family
GZ065_RS05025	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GZ065_RS05045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZ065_RS05050	COG0629	single-stranded DNA binding
GZ065_RS05075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GZ065_RS05085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GZ065_RS05100	COG0723	plastoquinol--plastocyanin reductase activity
GZ065_RS05125	COG1268	BioY protein
GZ065_RS05150	COG0045	succinate-CoA ligase (ADP-forming) activity
GZ065_RS05165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GZ065_RS05200	COG1475	DNA binding
GZ065_RS05205	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GZ065_RS05205	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GZ065_RS05215	COG0628	permease
GZ065_RS05225	COG4974	Belongs to the 'phage' integrase family
GZ065_RS05240	COG0372	Belongs to the citrate synthase family
GZ065_RS05305	COG0651	ATP synthesis coupled electron transport
GZ065_RS05310	COG0772	Belongs to the SEDS family
GZ065_RS05315	COG1104	cysteine desulfurase activity
GZ065_RS05325	COG3547	Transposase (IS116 IS110 IS902 family)
GZ065_RS05340	COG0492	ferredoxin-NADP+ reductase activity
GZ065_RS05355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZ065_RS05360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZ065_RS05365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GZ065_RS05370	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GZ065_RS05400	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GZ065_RS05410	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GZ065_RS05410	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GZ065_RS05415	COG1007	ATP synthesis coupled electron transport
GZ065_RS05420	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZ065_RS05425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GZ065_RS05430	COG0713	ATP synthesis coupled electron transport
GZ065_RS05435	COG0839	Belongs to the complex I subunit 6 family
GZ065_RS05455	COG3474	cytochrome
GZ065_RS05460	COG0632	four-way junction helicase activity
GZ065_RS05465	COG2255	four-way junction helicase activity
GZ065_RS05485	COG2827	Endonuclease containing a URI domain
GZ065_RS05495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GZ065_RS05510	COG2094	Belongs to the DNA glycosylase MPG family
GZ065_RS05545	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GZ065_RS05550	COG0799	negative regulation of ribosome biogenesis
GZ065_RS05560	COG0494	nUDIX hydrolase
GZ065_RS05565	COG0084	hydrolase, TatD family'
GZ065_RS05570	COG0039	L-malate dehydrogenase activity
GZ065_RS05575	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZ065_RS05580	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZ065_RS05585	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GZ065_RS05590	COG0537	adenosine 5'-monophosphoramidase activity
GZ065_RS05610	COG1090	epimerase
GZ065_RS05620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GZ065_RS05625	COG0416	fatty acid biosynthetic process
GZ065_RS05630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GZ065_RS05635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GZ065_RS05640	COG4175	Glycine betaine
GZ065_RS05645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GZ065_RS05665	COG0543	2 iron, 2 sulfur cluster binding
GZ065_RS05665	COG0493	'glutamate synthase
GZ065_RS05685	COG0750	zinc metalloprotease
GZ065_RS05700	COG0776	regulation of translation
GZ065_RS05705	COG0539	negative regulation of cytoplasmic translation
GZ065_RS05710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GZ065_RS05730	COG3328	transposase activity
GZ065_RS05765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GZ065_RS05770	COG1006	Multisubunit Na H antiporter MnhC subunit
GZ065_RS05785	COG1320	monovalent cation:proton antiporter activity
GZ065_RS05795	COG1758	RNA polymerase activity
GZ065_RS05805	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GZ065_RS05820	COG0330	HflC and HflK could
GZ065_RS05855	COG2009	succinate dehydrogenase
GZ065_RS05860	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GZ065_RS05875	COG4591	ABC-type transport system involved in lipoprotein release permease component
GZ065_RS05890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GZ065_RS05895	COG0312	modulator of DNA gyrase
GZ065_RS05900	COG1278	Cold shock
GZ065_RS05905	COG0513	Belongs to the DEAD box helicase family
GZ065_RS05920	COG1830	Aldolase
GZ065_RS05935	COG0167	dihydroorotate dehydrogenase activity
GZ065_RS05940	COG0571	ribonuclease III activity
GZ065_RS05945	COG1999	signal sequence binding
GZ065_RS05950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GZ065_RS05960	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GZ065_RS05965	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GZ065_RS05980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GZ065_RS05990	COG1034	ATP synthesis coupled electron transport
GZ065_RS05995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GZ065_RS06000	COG0113	porphobilinogen synthase activity
GZ065_RS06015	COG0752	glycyl-tRNA synthetase alpha subunit
GZ065_RS06020	COG0751	glycine-tRNA ligase activity
GZ065_RS06025	COG0322	excinuclease ABC activity
GZ065_RS06035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZ065_RS06055	COG1230	cation diffusion facilitator family transporter
GZ065_RS06065	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GZ065_RS06070	COG1115	amino acid carrier protein
GZ065_RS06075	COG1115	amino acid carrier protein
GZ065_RS06080	COG1183	phosphatidylcholine synthase activity
GZ065_RS06105	COG0187	DNA topoisomerase II activity
GZ065_RS06110	COG0154	amidase activity
GZ065_RS06115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZ065_RS06115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZ065_RS06145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZ065_RS06155	COG0307	riboflavin synthase, alpha
GZ065_RS06165	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GZ065_RS06170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GZ065_RS06190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GZ065_RS06195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GZ065_RS06205	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GZ065_RS06210	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GZ065_RS06220	COG1845	cytochrome c oxidase, subunit III
GZ065_RS06235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GZ065_RS06235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZ065_RS06265	COG0594	ribonuclease P activity
GZ065_RS06270	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GZ065_RS06275	COG0573	inorganic phosphate transmembrane transporter activity
GZ065_RS06280	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GZ065_RS06285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GZ065_RS06320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GZ065_RS06325	COG0051	transcription antitermination factor activity, RNA binding
GZ065_RS06330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GZ065_RS06335	COG0088	Forms part of the polypeptide exit tunnel
GZ065_RS06345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GZ065_RS06350	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GZ065_RS06355	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GZ065_RS06360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GZ065_RS06365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GZ065_RS06370	COG0255	Belongs to the universal ribosomal protein uL29 family
GZ065_RS06380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GZ065_RS06385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GZ065_RS06390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GZ065_RS06395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GZ065_RS06400	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GZ065_RS06405	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GZ065_RS06410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GZ065_RS06415	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GZ065_RS06420	COG0200	Binds to the 23S rRNA
GZ065_RS06425	COG0201	protein transport
GZ065_RS06430	COG0563	adenylate kinase activity
GZ065_RS06435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GZ065_RS06440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GZ065_RS06445	COG0202	RNA polymerase activity
GZ065_RS06450	COG0203	ribosomal protein L17
GZ065_RS06455	COG0792	nuclease activity
GZ065_RS06460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZ065_RS06465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GZ065_RS06470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GZ065_RS06500	COG0574	Belongs to the PEP-utilizing enzyme family
GZ065_RS06500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZ065_RS06515	COG1566	PFAM secretion protein HlyD family protein
GZ065_RS06520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GZ065_RS06530	COG0280	phosphate acetyltransferase
GZ065_RS06530	COG0281	malic enzyme
GZ065_RS06535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GZ065_RS06550	COG0217	transcriptional regulatory protein
GZ065_RS06555	COG0739	heme binding
GZ065_RS06585	COG2814	Major facilitator Superfamily
GZ065_RS06590	COG2226	methyltransferase
GZ065_RS06595	COG1132	(ABC) transporter
GZ065_RS06605	COG0018	arginyl-trna synthetase
GZ065_RS06610	COG4133	protoheme IX ABC transporter activity
GZ065_RS06620	COG0590	tRNA wobble adenosine to inosine editing
GZ065_RS06630	COG0504	CTP synthase activity
GZ065_RS06640	COG4451	ribulose bisphosphate carboxylase, small
GZ065_RS06640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GZ065_RS06665	COG1862	Preprotein translocase
GZ065_RS06675	COG0052	Belongs to the universal ribosomal protein uS2 family
GZ065_RS06680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GZ065_RS06685	COG0528	UMP kinase activity
GZ065_RS06690	COG0233	cytoplasmic translational termination
GZ065_RS06710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZ065_RS06715	COG0717	Belongs to the dCTP deaminase family
GZ065_RS06740	COG3736	Type IV secretory pathway, component VirB8
GZ065_RS06755	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
GZ065_RS06770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZ065_RS06775	COG0477	Major facilitator Superfamily
GZ065_RS06780	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GZ065_RS06785	COG0552	protein localization to endoplasmic reticulum
GZ065_RS06790	COG0822	iron-sulfur transferase activity
GZ065_RS06795	COG0316	Belongs to the HesB IscA family
GZ065_RS06800	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GZ065_RS06810	COG0681	Belongs to the peptidase S26 family
GZ065_RS06820	COG0022	dehydrogenase e1 component
GZ065_RS06820	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZ065_RS06835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GZ065_RS06840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GZ065_RS06855	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZ065_RS06855	COG0022	dehydrogenase e1 component
GZ065_RS06920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZ065_RS06925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZ065_RS06955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GZ065_RS06965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GZ065_RS06970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GZ065_RS06990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GZ065_RS06995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GZ065_RS07110	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GZ065_RS07135	COG4804	nuclease activity
GZ065_RS07170	COG3547	Transposase (IS116 IS110 IS902 family)
GZ065_RS07205	COG3328	transposase activity
GZ065_RS07210	COG3547	Transposase (IS116 IS110 IS902 family)
GZ065_RS07325	COG2801	Transposase and inactivated derivatives
GZ065_RS07330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GZ065_RS07335	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GZ065_RS07340	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GZ065_RS07350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZ065_RS07360	COG0174	glutamine synthetase