locus-tag	class	description
FK497_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FK497_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
FK497_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FK497_RS00105	COG0424	maF-like protein
FK497_RS00115	COG1115	amino acid carrier protein
FK497_RS00125	COG0459	protein refolding
FK497_RS00130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FK497_RS00150	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FK497_RS00165	COG2239	Acts as a magnesium transporter
FK497_RS00185	COG0564	pseudouridine synthase activity
FK497_RS00195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FK497_RS00215	COG1138	Cytochrome C-type biogenesis protein
FK497_RS00245	COG1686	Belongs to the peptidase S11 family
FK497_RS00250	COG1322	Protein conserved in bacteria
FK497_RS00270	COG0653	protein targeting
FK497_RS00280	COG2801	Transposase and inactivated derivatives
FK497_RS00295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FK497_RS00305	COG2801	Transposase and inactivated derivatives
FK497_RS00315	COG0626	cystathionine gamma-synthase activity
FK497_RS00320	COG0271	Belongs to the BolA IbaG family
FK497_RS00325	COG0443	Heat shock 70 kDa protein
FK497_RS00330	COG1530	ribonuclease E activity
FK497_RS00335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FK497_RS00345	COG1121	(ABC) transporter
FK497_RS00350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FK497_RS00365	COG0450	alkyl hydroperoxide reductase
FK497_RS00380	COG0805	protein transport
FK497_RS00420	COG0617	tRNA 3'-terminal CCA addition
FK497_RS00430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FK497_RS00430	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FK497_RS00445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FK497_RS00460	COG1074	ATP-dependent DNA helicase activity
FK497_RS00465	COG3088	subunit of a heme lyase
FK497_RS00480	COG0484	heat shock protein binding
FK497_RS00490	COG0358	DNA primase activity
FK497_RS00495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FK497_RS00515	COG0235	Class ii aldolase
FK497_RS00530	COG2801	Transposase and inactivated derivatives
FK497_RS00540	COG0484	heat shock protein binding
FK497_RS00545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FK497_RS00590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FK497_RS00595	COG0148	phosphopyruvate hydratase activity
FK497_RS00610	COG3346	SURF1 family
FK497_RS00640	COG0114	fumarate hydratase activity
FK497_RS00655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FK497_RS00670	COG0484	heat shock protein binding
FK497_RS00680	COG0823	Involved in the tonB-independent uptake of proteins
FK497_RS00685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FK497_RS00690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FK497_RS00725	COG2801	Transposase and inactivated derivatives
FK497_RS00750	COG3328	transposase activity
FK497_RS00990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FK497_RS00995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FK497_RS01015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FK497_RS01020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FK497_RS01030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FK497_RS01060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FK497_RS01075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FK497_RS01090	COG0508	dehydrogenase complex catalyzes the overall conversion of
FK497_RS01090	COG0022	dehydrogenase e1 component
FK497_RS01100	COG0681	Belongs to the peptidase S26 family
FK497_RS01110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FK497_RS01115	COG0316	Belongs to the HesB IscA family
FK497_RS01120	COG0822	iron-sulfur transferase activity
FK497_RS01125	COG0552	protein localization to endoplasmic reticulum
FK497_RS01130	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FK497_RS01135	COG0477	Major facilitator Superfamily
FK497_RS01140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FK497_RS01155	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FK497_RS01170	COG3736	Type IV secretory pathway, component VirB8
FK497_RS01190	COG0717	Belongs to the dCTP deaminase family
FK497_RS01195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FK497_RS01215	COG0233	cytoplasmic translational termination
FK497_RS01220	COG0528	UMP kinase activity
FK497_RS01225	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FK497_RS01230	COG0052	Belongs to the universal ribosomal protein uS2 family
FK497_RS01240	COG1862	Preprotein translocase
FK497_RS01275	COG0504	CTP synthase activity
FK497_RS01285	COG0590	tRNA wobble adenosine to inosine editing
FK497_RS01295	COG4133	protoheme IX ABC transporter activity
FK497_RS01300	COG0018	arginyl-trna synthetase
FK497_RS01310	COG1132	(ABC) transporter
FK497_RS01315	COG2226	methyltransferase
FK497_RS01320	COG2814	Major facilitator Superfamily
FK497_RS01355	COG0739	heme binding
FK497_RS01360	COG0217	transcriptional regulatory protein
FK497_RS01375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FK497_RS01380	COG0281	malic enzyme
FK497_RS01380	COG0280	phosphate acetyltransferase
FK497_RS01390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FK497_RS01395	COG1566	PFAM secretion protein HlyD family protein
FK497_RS01410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FK497_RS01410	COG0574	Belongs to the PEP-utilizing enzyme family
FK497_RS01440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK497_RS01445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FK497_RS01450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FK497_RS01455	COG0792	nuclease activity
FK497_RS01460	COG0203	ribosomal protein L17
FK497_RS01465	COG0202	RNA polymerase activity
FK497_RS01470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FK497_RS01475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FK497_RS01480	COG0563	adenylate kinase activity
FK497_RS01485	COG0201	protein transport
FK497_RS01490	COG0200	Binds to the 23S rRNA
FK497_RS01495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FK497_RS01500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FK497_RS01505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FK497_RS01510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FK497_RS01515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FK497_RS01520	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FK497_RS01525	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FK497_RS01530	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FK497_RS01540	COG0255	Belongs to the universal ribosomal protein uL29 family
FK497_RS01545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FK497_RS01550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FK497_RS01555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FK497_RS01560	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FK497_RS01565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FK497_RS01575	COG0088	Forms part of the polypeptide exit tunnel
FK497_RS01580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FK497_RS01585	COG0051	transcription antitermination factor activity, RNA binding
FK497_RS01590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FK497_RS01625	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FK497_RS01630	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FK497_RS01635	COG0573	inorganic phosphate transmembrane transporter activity
FK497_RS01640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FK497_RS01645	COG0594	ribonuclease P activity
FK497_RS01670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FK497_RS01670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FK497_RS01685	COG1845	cytochrome c oxidase, subunit III
FK497_RS01695	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FK497_RS01700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FK497_RS01710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FK497_RS01715	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FK497_RS01735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FK497_RS01740	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FK497_RS01750	COG0307	riboflavin synthase, alpha
FK497_RS01760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FK497_RS01790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FK497_RS01790	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FK497_RS01795	COG0154	amidase activity
FK497_RS01800	COG0187	DNA topoisomerase II activity
FK497_RS01820	COG1183	phosphatidylcholine synthase activity
FK497_RS01825	COG1115	amino acid carrier protein
FK497_RS01830	COG1115	amino acid carrier protein
FK497_RS01835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FK497_RS01845	COG1230	cation diffusion facilitator family transporter
FK497_RS01865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK497_RS01875	COG0322	excinuclease ABC activity
FK497_RS01880	COG0751	glycine-tRNA ligase activity
FK497_RS01885	COG0752	glycyl-tRNA synthetase alpha subunit
FK497_RS01900	COG0113	porphobilinogen synthase activity
FK497_RS01905	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FK497_RS01910	COG1034	ATP synthesis coupled electron transport
FK497_RS01920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FK497_RS01935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FK497_RS01940	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FK497_RS01950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FK497_RS01955	COG1999	signal sequence binding
FK497_RS01960	COG0571	ribonuclease III activity
FK497_RS01965	COG0167	dihydroorotate dehydrogenase activity
FK497_RS01980	COG1830	Aldolase
FK497_RS01995	COG0513	Belongs to the DEAD box helicase family
FK497_RS02000	COG1278	Cold shock
FK497_RS02005	COG0312	modulator of DNA gyrase
FK497_RS02010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FK497_RS02025	COG4591	ABC-type transport system involved in lipoprotein release permease component
FK497_RS02040	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FK497_RS02045	COG2009	succinate dehydrogenase
FK497_RS02075	COG0330	HflC and HflK could
FK497_RS02090	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FK497_RS02100	COG1758	RNA polymerase activity
FK497_RS02110	COG1320	monovalent cation:proton antiporter activity
FK497_RS02125	COG1006	Multisubunit Na H antiporter MnhC subunit
FK497_RS02130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FK497_RS02160	COG3328	transposase activity
FK497_RS02180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FK497_RS02185	COG0539	negative regulation of cytoplasmic translation
FK497_RS02190	COG0776	regulation of translation
FK497_RS02205	COG0750	zinc metalloprotease
FK497_RS02225	COG0493	'glutamate synthase
FK497_RS02225	COG0543	2 iron, 2 sulfur cluster binding
FK497_RS02245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FK497_RS02250	COG4175	Glycine betaine
FK497_RS02255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FK497_RS02260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FK497_RS02265	COG0416	fatty acid biosynthetic process
FK497_RS02270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FK497_RS02280	COG1090	epimerase
FK497_RS02300	COG0537	adenosine 5'-monophosphoramidase activity
FK497_RS02305	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK497_RS02310	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK497_RS02315	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK497_RS02320	COG0039	L-malate dehydrogenase activity
FK497_RS02325	COG0084	hydrolase, TatD family'
FK497_RS02330	COG0494	nUDIX hydrolase
FK497_RS02340	COG0799	negative regulation of ribosome biogenesis
FK497_RS02345	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FK497_RS02380	COG2094	Belongs to the DNA glycosylase MPG family
FK497_RS02395	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FK497_RS02405	COG2827	Endonuclease containing a URI domain
FK497_RS02425	COG2255	four-way junction helicase activity
FK497_RS02430	COG0632	four-way junction helicase activity
FK497_RS02435	COG3474	cytochrome
FK497_RS02455	COG0839	Belongs to the complex I subunit 6 family
FK497_RS02460	COG0713	ATP synthesis coupled electron transport
FK497_RS02465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FK497_RS02470	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK497_RS02475	COG1007	ATP synthesis coupled electron transport
FK497_RS02480	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FK497_RS02480	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FK497_RS02490	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FK497_RS02520	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FK497_RS02525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FK497_RS02530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FK497_RS02535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK497_RS02550	COG0492	ferredoxin-NADP+ reductase activity
FK497_RS02575	COG1104	cysteine desulfurase activity
FK497_RS02580	COG0772	Belongs to the SEDS family
FK497_RS02645	COG0372	Belongs to the citrate synthase family
FK497_RS02660	COG4974	Belongs to the 'phage' integrase family
FK497_RS02670	COG0628	permease
FK497_RS02680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FK497_RS02680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FK497_RS02685	COG1475	DNA binding
FK497_RS02720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FK497_RS02735	COG0045	succinate-CoA ligase (ADP-forming) activity
FK497_RS02760	COG1268	BioY protein
FK497_RS02785	COG0723	plastoquinol--plastocyanin reductase activity
FK497_RS02800	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FK497_RS02810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FK497_RS02835	COG0629	single-stranded DNA binding
FK497_RS02840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FK497_RS02860	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FK497_RS02865	COG0670	Belongs to the BI1 family
FK497_RS02870	COG1104	cysteine desulfurase activity
FK497_RS02875	COG2945	thiolester hydrolase activity
FK497_RS02885	COG0316	Belongs to the HesB IscA family
FK497_RS02890	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FK497_RS02895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK497_RS02895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK497_RS02905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FK497_RS02910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FK497_RS02915	COG1185	polyribonucleotide nucleotidyltransferase activity
FK497_RS02920	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FK497_RS02935	COG0126	phosphoglycerate kinase activity
FK497_RS02940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FK497_RS02960	COG0436	Aminotransferase
FK497_RS02965	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FK497_RS02970	COG1253	flavin adenine dinucleotide binding
FK497_RS02985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FK497_RS02990	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FK497_RS02995	COG0336	Belongs to the RNA methyltransferase TrmD family
FK497_RS03000	COG0335	large ribosomal subunit rRNA binding
FK497_RS03005	COG0581	inorganic phosphate transmembrane transporter activity
FK497_RS03010	COG0047	phosphoribosylformylglycinamidine synthase activity
FK497_RS03030	COG0259	pyridoxamine-phosphate oxidase activity
FK497_RS03035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FK497_RS03055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FK497_RS03085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK497_RS03095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FK497_RS03105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FK497_RS03110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FK497_RS03130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FK497_RS03165	COG0564	pseudouridine synthase activity
FK497_RS03170	COG3328	transposase activity
FK497_RS03190	COG0312	modulator of DNA gyrase
FK497_RS03210	COG0285	dihydrofolate synthase activity
FK497_RS03225	COG2867	negative regulation of translational initiation
FK497_RS03255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FK497_RS03260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FK497_RS03270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FK497_RS03285	COG0101	tRNA pseudouridine synthase activity
FK497_RS03290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FK497_RS03295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FK497_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
FK497_RS03305	COG1295	ribonuclease BN
FK497_RS03320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FK497_RS03330	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
FK497_RS03335	COG1573	uracil-dna glycosylase
FK497_RS03340	COG0242	peptide deformylase activity
FK497_RS03345	COG0849	cell division
FK497_RS03350	COG0024	Methionine aminopeptidase
FK497_RS03355	COG0477	Major facilitator Superfamily
FK497_RS03360	COG0275	rRNA processing
FK497_RS03370	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FK497_RS03380	COG3335	DDE superfamily endonuclease
FK497_RS03395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FK497_RS03400	COG0037	tRNA processing
FK497_RS03405	COG2885	chlorophyll binding
FK497_RS03420	COG0482	sulfurtransferase activity
FK497_RS03430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FK497_RS03440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK497_RS03445	COG0493	'glutamate synthase
FK497_RS03445	COG0543	2 iron, 2 sulfur cluster binding
FK497_RS03470	COG1178	ABC-type Fe3 transport system permease component
FK497_RS03480	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FK497_RS03485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FK497_RS03495	COG1113	amino acid transport
FK497_RS03500	COG0531	amino acid
FK497_RS03510	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FK497_RS03515	COG0124	histidyl-tRNA synthetase
FK497_RS03525	COG0484	heat shock protein binding
FK497_RS03550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FK497_RS03555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FK497_RS03555	COG2857	Cytochrome c1
FK497_RS03560	COG0556	nucleotide-excision repair
FK497_RS03570	COG0776	regulation of translation
FK497_RS03585	COG0495	leucyl-tRNA aminoacylation
FK497_RS03600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FK497_RS03605	COG0163	prenyltransferase activity
FK497_RS03610	COG3750	Belongs to the UPF0335 family
FK497_RS03615	COG4536	flavin adenine dinucleotide binding
FK497_RS03620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FK497_RS03625	COG0105	UTP biosynthetic process
FK497_RS03635	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FK497_RS03650	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FK497_RS03655	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FK497_RS03665	COG0142	geranyltranstransferase activity
FK497_RS03670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK497_RS03675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FK497_RS03685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FK497_RS03690	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
FK497_RS03700	COG0666	response to abiotic stimulus
FK497_RS03725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FK497_RS03740	COG0326	Molecular chaperone. Has ATPase activity
FK497_RS03750	COG0156	8-amino-7-oxononanoate synthase activity
FK497_RS03760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FK497_RS03765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FK497_RS03775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FK497_RS03780	COG2205	protein histidine kinase activity
FK497_RS03790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FK497_RS03810	COG0508	dehydrogenase complex catalyzes the overall conversion of
FK497_RS03850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FK497_RS03870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FK497_RS03875	COG1301	dicarboxylic acid transport
FK497_RS03885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FK497_RS03900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FK497_RS03950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FK497_RS03990	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
FK497_RS04000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FK497_RS04000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FK497_RS04045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FK497_RS04065	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FK497_RS04070	COG0359	binds to the 23S rRNA
FK497_RS04080	COG0360	Binds together with S18 to 16S ribosomal RNA
FK497_RS04090	COG1619	proteins homologs of microcin C7 resistance protein MccF
FK497_RS04095	COG0321	lipoyl(octanoyl) transferase activity
FK497_RS04115	COG4695	Portal protein
FK497_RS04130	COG2801	Transposase and inactivated derivatives
FK497_RS04140	COG0728	peptidoglycan biosynthetic process
FK497_RS04155	COG0445	tRNA wobble uridine modification
FK497_RS04160	COG0006	proline dipeptidase activity
FK497_RS04180	COG0666	response to abiotic stimulus
FK497_RS04185	COG3328	transposase activity
FK497_RS04195	COG3451	type IV secretory pathway VirB4
FK497_RS04210	COG2070	2-Nitropropane dioxygenase
FK497_RS04225	COG0649	NAD binding
FK497_RS04240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FK497_RS04250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FK497_RS04260	COG3328	transposase activity
FK497_RS04265	COG0072	phenylalanine-tRNA ligase activity
FK497_RS04265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK497_RS04275	COG0356	it plays a direct role in the translocation of protons across the membrane
FK497_RS04280	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FK497_RS04295	COG1215	transferase activity, transferring glycosyl groups
FK497_RS04300	COG1612	heme a metabolic process
FK497_RS04305	COG4770	biotin carboxylase activity
FK497_RS04315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FK497_RS04320	COG0071	Belongs to the small heat shock protein (HSP20) family
FK497_RS04325	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FK497_RS04340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FK497_RS04350	COG3827	peptidoglycan binding
FK497_RS04355	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FK497_RS04390	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
FK497_RS04400	COG3451	type IV secretory pathway VirB4
FK497_RS04405	COG3704	protein secretion by the type IV secretion system
FK497_RS04410	COG3704	protein secretion by the type IV secretion system
FK497_RS04415	COG1340	protein secretion by the type IV secretion system
FK497_RS04415	COG3704	protein secretion by the type IV secretion system
FK497_RS04430	COG0742	ribosomal rna small subunit methyltransferase
FK497_RS04445	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FK497_RS04460	COG0473	3-isopropylmalate dehydrogenase activity
FK497_RS04480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FK497_RS04490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FK497_RS04495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FK497_RS04495	COG0085	RNA polymerase activity
FK497_RS04500	COG0222	ribosome binding
FK497_RS04505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FK497_RS04510	COG0081	regulation of translation
FK497_RS04515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FK497_RS04520	COG0250	Participates in transcription elongation, termination and antitermination
FK497_RS04535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FK497_RS04540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FK497_RS04545	COG0049	tRNA binding
FK497_RS04550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FK497_RS04555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FK497_RS04555	COG2890	protein-(glutamine-N5) methyltransferase activity
FK497_RS04580	COG0544	peptidyl-prolyl cis-trans isomerase activity
FK497_RS04585	COG0740	serine-type endopeptidase activity
FK497_RS04590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FK497_RS04595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FK497_RS04600	COG0768	penicillin binding
FK497_RS04605	COG0726	polysaccharide deacetylase
FK497_RS04610	COG0606	chelatase, subunit chli
FK497_RS04630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FK497_RS04635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FK497_RS04650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FK497_RS04655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FK497_RS04660	COG0745	RESPONSE REGULATOR receiver
FK497_RS04675	COG0666	response to abiotic stimulus
FK497_RS04690	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FK497_RS04695	COG0343	queuine tRNA-ribosyltransferase activity
FK497_RS04705	COG0612	Peptidase, M16
FK497_RS04710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FK497_RS04735	COG2171	N-acyltransferase activity
FK497_RS04745	COG1053	succinate dehydrogenase
FK497_RS04755	COG0194	GDP metabolic process
FK497_RS04770	COG0540	Belongs to the ATCase OTCase family
FK497_RS04775	COG1840	ABC-type Fe3 transport system, periplasmic component
FK497_RS04785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FK497_RS04790	COG0254	rRNA binding
FK497_RS04795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FK497_RS04805	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FK497_RS04830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FK497_RS04855	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FK497_RS04860	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FK497_RS04895	COG0567	Dehydrogenase, E1 component
FK497_RS04925	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FK497_RS04930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FK497_RS04940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FK497_RS04945	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FK497_RS04965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FK497_RS05000	COG0612	Peptidase, M16
FK497_RS05005	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FK497_RS05010	COG0196	riboflavin kinase activity
FK497_RS05030	COG0305	Participates in initiation and elongation during chromosome replication
FK497_RS05040	COG1714	RDD family
FK497_RS05055	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FK497_RS05060	COG0237	dephospho-CoA kinase activity
FK497_RS05080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK497_RS05095	COG0542	response to heat
FK497_RS05100	COG2902	Dehydrogenase
FK497_RS05115	COG1381	Involved in DNA repair and RecF pathway recombination
FK497_RS05130	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FK497_RS05160	COG2003	Belongs to the UPF0758 family
FK497_RS05170	COG1396	sequence-specific DNA binding
FK497_RS05180	COG2801	Transposase and inactivated derivatives
FK497_RS05190	COG4804	nuclease activity
FK497_RS05295	COG2801	Transposase and inactivated derivatives
FK497_RS05375	COG2003	Belongs to the UPF0758 family
FK497_RS05530	COG3328	transposase activity
FK497_RS05580	COG2003	Belongs to the UPF0758 family
FK497_RS05620	COG3621	Patatin-like phospholipase
FK497_RS05640	COG2801	Transposase and inactivated derivatives
FK497_RS05650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FK497_RS05750	COG3328	transposase activity
FK497_RS05815	COG2003	Belongs to the UPF0758 family
FK497_RS05830	COG3621	Patatin-like phospholipase
FK497_RS05990	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FK497_RS06015	COG4804	nuclease activity
FK497_RS06085	COG3328	transposase activity
FK497_RS06195	COG0508	dehydrogenase complex catalyzes the overall conversion of
FK497_RS06205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FK497_RS06210	COG0575	Belongs to the CDS family
FK497_RS06220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FK497_RS06235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK497_RS06245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FK497_RS06255	COG2814	Major facilitator Superfamily
FK497_RS06275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FK497_RS06280	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FK497_RS06285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FK497_RS06330	COG1181	Belongs to the D-alanine--D-alanine ligase family
FK497_RS06345	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FK497_RS06350	COG0758	DNA mediated transformation
FK497_RS06360	COG0149	triose-phosphate isomerase activity
FK497_RS06370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FK497_RS06380	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FK497_RS06390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK497_RS06395	COG0228	four-way junction DNA binding
FK497_RS06400	COG0142	geranyltranstransferase activity
FK497_RS06405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FK497_RS06425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FK497_RS06430	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FK497_RS06435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FK497_RS06445	COG1450	Type ii and iii secretion system protein
FK497_RS06450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FK497_RS06450	COG0519	Catalyzes the synthesis of GMP from XMP
FK497_RS06455	COG1253	flavin adenine dinucleotide binding
FK497_RS06465	COG0481	GTPase activity
FK497_RS06475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FK497_RS06485	COG2801	Transposase and inactivated derivatives
FK497_RS06510	COG2801	Transposase and inactivated derivatives
FK497_RS06530	COG0470	DNA polymerase III
FK497_RS06535	COG0009	L-threonylcarbamoyladenylate synthase
FK497_RS06545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FK497_RS06585	COG2003	Belongs to the UPF0758 family
FK497_RS06600	COG3621	Patatin-like phospholipase
FK497_RS06625	COG2801	Transposase and inactivated derivatives
FK497_RS06655	COG2003	Belongs to the UPF0758 family
FK497_RS06745	COG3577	Aspartyl protease
FK497_RS06800	COG2801	Transposase and inactivated derivatives
FK497_RS06805	COG0736	holo-[acyl-carrier-protein] synthase activity
FK497_RS06825	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FK497_RS06840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FK497_RS06850	COG2801	Transposase and inactivated derivatives
FK497_RS06870	COG3328	transposase activity
FK497_RS06885	COG0284	orotidine-5'-phosphate decarboxylase activity
FK497_RS06895	COG2801	Transposase and inactivated derivatives
FK497_RS06915	COG0525	valine-tRNA ligase activity
FK497_RS06925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FK497_RS06935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK497_RS06940	COG4974	Belongs to the 'phage' integrase family
FK497_RS06945	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FK497_RS06950	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FK497_RS06960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK497_RS06965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FK497_RS06970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FK497_RS06990	COG0215	cysteine-tRNA ligase activity
FK497_RS06995	COG3932	Exopolysaccharide synthesis, ExoD
FK497_RS07005	COG2801	Transposase and inactivated derivatives
FK497_RS07015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FK497_RS07020	COG3842	ATPase activity
FK497_RS07035	COG1494	fructose-1,6-bisphosphatase
FK497_RS07045	COG0012	GTP binding
FK497_RS07075	COG2801	Transposase and inactivated derivatives
FK497_RS07180	COG2003	Belongs to the UPF0758 family
FK497_RS07335	COG3328	transposase activity
FK497_RS07385	COG2003	Belongs to the UPF0758 family
FK497_RS07405	COG3621	Patatin-like phospholipase
FK497_RS07640	COG2801	Transposase and inactivated derivatives
FK497_RS07645	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FK497_RS07650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FK497_RS07655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FK497_RS07665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FK497_RS07675	COG0174	glutamine synthetase