locus-tag	class	description
EA652_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EA652_RS00025	COG3736	Type IV secretory pathway, component VirB8
EA652_RS00040	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
EA652_RS00045	COG3505	Type IV secretory pathway VirD4
EA652_RS00075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EA652_RS00090	COG0250	Participates in transcription elongation, termination and antitermination
EA652_RS00095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EA652_RS00100	COG0081	regulation of translation
EA652_RS00105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EA652_RS00110	COG0222	ribosome binding
EA652_RS00115	COG0085	RNA polymerase activity
EA652_RS00115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EA652_RS00120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EA652_RS00130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EA652_RS00155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EA652_RS00160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EA652_RS00220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EA652_RS00260	COG2801	Transposase and inactivated derivatives
EA652_RS00300	COG3827	peptidoglycan binding
EA652_RS00305	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EA652_RS00330	COG2801	Transposase and inactivated derivatives
EA652_RS00365	COG0489	protein tyrosine kinase activity
EA652_RS00370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EA652_RS00410	COG0477	Major facilitator Superfamily
EA652_RS00415	COG0024	Methionine aminopeptidase
EA652_RS00420	COG0849	cell division
EA652_RS00430	COG1573	uracil-dna glycosylase
EA652_RS00450	COG1034	ATP synthesis coupled electron transport
EA652_RS00455	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EA652_RS00460	COG0113	porphobilinogen synthase activity
EA652_RS00470	COG0752	glycyl-tRNA synthetase alpha subunit
EA652_RS00490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EA652_RS00495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EA652_RS00505	COG3932	Exopolysaccharide synthesis, ExoD
EA652_RS00550	COG1845	cytochrome c oxidase, subunit III
EA652_RS00560	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EA652_RS00565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EA652_RS00575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EA652_RS00590	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EA652_RS00605	COG0307	riboflavin synthase, alpha
EA652_RS00640	COG1674	ftsk spoiiie
EA652_RS00655	COG3344	reverse transcriptase
EA652_RS00695	COG2801	Transposase and inactivated derivatives
EA652_RS00705	COG0187	DNA topoisomerase II activity
EA652_RS00715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EA652_RS00730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EA652_RS00755	COG1686	Belongs to the peptidase S11 family
EA652_RS00765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EA652_RS00780	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EA652_RS00785	COG0758	DNA mediated transformation
EA652_RS00790	COG0149	triose-phosphate isomerase activity
EA652_RS00820	COG2801	Transposase and inactivated derivatives
EA652_RS00825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EA652_RS00830	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EA652_RS00860	COG2801	Transposase and inactivated derivatives
EA652_RS00870	COG0237	dephospho-CoA kinase activity
EA652_RS00875	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EA652_RS00900	COG1253	flavin adenine dinucleotide binding
EA652_RS00910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EA652_RS00910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EA652_RS00950	COG0573	inorganic phosphate transmembrane transporter activity
EA652_RS00960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EA652_RS00990	COG2801	Transposase and inactivated derivatives
EA652_RS01005	COG0235	Class ii aldolase
EA652_RS01065	COG2902	Dehydrogenase
EA652_RS01070	COG0542	response to heat
EA652_RS01085	COG1217	gtp-binding protein TYPA
EA652_RS01090	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EA652_RS01095	COG1301	dicarboxylic acid transport
EA652_RS01110	COG1138	Cytochrome C-type biogenesis protein
EA652_RS01185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EA652_RS01195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EA652_RS01200	COG2814	Major facilitator Superfamily
EA652_RS01225	COG2801	Transposase and inactivated derivatives
EA652_RS01230	COG1322	Protein conserved in bacteria
EA652_RS01250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EA652_RS01300	COG0114	fumarate hydratase activity
EA652_RS01320	COG0280	phosphate acetyltransferase
EA652_RS01320	COG0281	malic enzyme
EA652_RS01325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EA652_RS01345	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EA652_RS01355	COG0739	heme binding
EA652_RS01390	COG0805	protein transport
EA652_RS01395	COG1438	arginine binding
EA652_RS01400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EA652_RS01405	COG0765	amino acid transport
EA652_RS01410	COG1126	abc transporter atp-binding protein
EA652_RS01430	COG0284	orotidine-5'-phosphate decarboxylase activity
EA652_RS01445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EA652_RS01455	COG0525	valine-tRNA ligase activity
EA652_RS01475	COG0504	CTP synthase activity
EA652_RS01480	COG0590	tRNA wobble adenosine to inosine editing
EA652_RS01500	COG0477	Major facilitator Superfamily
EA652_RS01510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EA652_RS01515	COG0022	dehydrogenase e1 component
EA652_RS01515	COG0508	dehydrogenase complex catalyzes the overall conversion of
EA652_RS01565	COG0617	tRNA 3'-terminal CCA addition
EA652_RS01575	COG0012	GTP binding
EA652_RS01590	COG0194	GDP metabolic process
EA652_RS01600	COG1053	succinate dehydrogenase
EA652_RS01610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EA652_RS01620	COG4770	biotin carboxylase activity
EA652_RS01645	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EA652_RS01660	COG0072	phenylalanine-tRNA ligase activity
EA652_RS01660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EA652_RS01670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EA652_RS01680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EA652_RS01685	COG1981	membrane
EA652_RS01690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EA652_RS01695	COG0564	pseudouridine synthase activity
EA652_RS01700	COG0477	Major facilitator Superfamily
EA652_RS01715	COG4133	protoheme IX ABC transporter activity
EA652_RS01775	COG0575	Belongs to the CDS family
EA652_RS01780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EA652_RS01795	COG0528	UMP kinase activity
EA652_RS01815	COG1862	Preprotein translocase
EA652_RS01835	COG3344	reverse transcriptase
EA652_RS01860	COG0508	dehydrogenase complex catalyzes the overall conversion of
EA652_RS01885	COG0653	protein targeting
EA652_RS01900	COG2801	Transposase and inactivated derivatives
EA652_RS01915	COG3344	reverse transcriptase
EA652_RS01930	COG1132	(ABC) transporter
EA652_RS01955	COG0018	arginyl-trna synthetase
EA652_RS01960	COG2801	Transposase and inactivated derivatives
EA652_RS01975	COG0649	NAD binding
EA652_RS01980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EA652_RS01985	COG4536	flavin adenine dinucleotide binding
EA652_RS01995	COG0163	prenyltransferase activity
EA652_RS02010	COG2801	Transposase and inactivated derivatives
EA652_RS02065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EA652_RS02090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EA652_RS02125	COG2814	Major facilitator Superfamily
EA652_RS02155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EA652_RS02160	COG2239	Acts as a magnesium transporter
EA652_RS02170	COG2801	Transposase and inactivated derivatives
EA652_RS02210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EA652_RS02225	COG1074	ATP-dependent DNA helicase activity
EA652_RS02235	COG2003	Belongs to the UPF0758 family
EA652_RS02240	COG1714	RDD family
EA652_RS02250	COG0305	Participates in initiation and elongation during chromosome replication
EA652_RS02265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EA652_RS02275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EA652_RS02285	COG0358	DNA primase activity
EA652_RS02300	COG2801	Transposase and inactivated derivatives
EA652_RS02330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EA652_RS02365	COG1115	amino acid carrier protein
EA652_RS02410	COG0354	folic acid binding
EA652_RS02415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EA652_RS02425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EA652_RS02435	COG1132	(ABC) transporter
EA652_RS02440	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EA652_RS02445	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EA652_RS02455	COG0544	peptidyl-prolyl cis-trans isomerase activity
EA652_RS02485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EA652_RS02535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EA652_RS02540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EA652_RS02560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EA652_RS02585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EA652_RS02600	COG0792	nuclease activity
EA652_RS02610	COG0202	RNA polymerase activity
EA652_RS02620	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EA652_RS02630	COG0201	protein transport
EA652_RS02640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EA652_RS02650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EA652_RS02660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EA652_RS02695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EA652_RS02725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EA652_RS02735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EA652_RS02765	COG1494	fructose-1,6-bisphosphatase
EA652_RS02780	COG0574	Belongs to the PEP-utilizing enzyme family
EA652_RS02780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EA652_RS02790	COG3344	reverse transcriptase
EA652_RS02935	COG0666	response to abiotic stimulus
EA652_RS02945	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EA652_RS02985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EA652_RS03005	COG0450	alkyl hydroperoxide reductase
EA652_RS03020	COG0196	riboflavin kinase activity
EA652_RS03025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EA652_RS03030	COG0612	Peptidase, M16
EA652_RS03040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EA652_RS03100	COG0629	single-stranded DNA binding
EA652_RS03105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EA652_RS03115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EA652_RS03130	COG0360	Binds together with S18 to 16S ribosomal RNA
EA652_RS03150	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EA652_RS03165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EA652_RS03185	COG0473	3-isopropylmalate dehydrogenase activity
EA652_RS03200	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EA652_RS03235	COG4804	nuclease activity
EA652_RS03380	COG3621	Patatin-like phospholipase
EA652_RS03405	COG0666	response to abiotic stimulus
EA652_RS03420	COG0071	Belongs to the small heat shock protein (HSP20) family
EA652_RS03520	COG2003	Belongs to the UPF0758 family
EA652_RS03530	COG0768	penicillin binding
EA652_RS03560	COG2171	N-acyltransferase activity
EA652_RS03570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EA652_RS03580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EA652_RS03580	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EA652_RS03585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EA652_RS03590	COG0316	Belongs to the HesB IscA family
EA652_RS03605	COG2945	thiolester hydrolase activity
EA652_RS03610	COG1104	cysteine desulfurase activity
EA652_RS03630	COG2801	Transposase and inactivated derivatives
EA652_RS03665	COG4974	Belongs to the 'phage' integrase family
EA652_RS03710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EA652_RS03715	COG1294	oxidase, subunit
EA652_RS03720	COG1271	oxidase subunit
EA652_RS03725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EA652_RS03730	COG0612	Peptidase, M16
EA652_RS03740	COG0343	queuine tRNA-ribosyltransferase activity
EA652_RS03745	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EA652_RS03760	COG0745	RESPONSE REGULATOR receiver
EA652_RS03770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EA652_RS03785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EA652_RS03815	COG0606	chelatase, subunit chli
EA652_RS03890	COG0142	geranyltranstransferase activity
EA652_RS03910	COG3474	cytochrome
EA652_RS03960	COG0009	L-threonylcarbamoyladenylate synthase
EA652_RS03980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EA652_RS04030	COG0330	HflC and HflK could
EA652_RS04065	COG0556	nucleotide-excision repair
EA652_RS04085	COG3088	subunit of a heme lyase
EA652_RS04085	COG4235	cytochrome complex assembly
EA652_RS04105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EA652_RS04125	COG0742	ribosomal rna small subunit methyltransferase
EA652_RS04140	COG3704	protein secretion by the type IV secretion system
EA652_RS04145	COG3704	protein secretion by the type IV secretion system
EA652_RS04150	COG3704	protein secretion by the type IV secretion system
EA652_RS04155	COG3451	type IV secretory pathway VirB4
EA652_RS04165	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EA652_RS04180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EA652_RS04215	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EA652_RS04220	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EA652_RS04225	COG0254	rRNA binding
EA652_RS04230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EA652_RS04255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EA652_RS04295	COG1840	ABC-type Fe3 transport system, periplasmic component
EA652_RS04305	COG0681	Belongs to the peptidase S26 family
EA652_RS04310	COG0443	Heat shock 70 kDa protein
EA652_RS04315	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EA652_RS04320	COG0316	Belongs to the HesB IscA family
EA652_RS04325	COG0822	iron-sulfur transferase activity
EA652_RS04330	COG0552	protein localization to endoplasmic reticulum
EA652_RS04335	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EA652_RS04360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EA652_RS04365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EA652_RS04365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EA652_RS04375	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
EA652_RS04420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EA652_RS04450	COG0626	cystathionine gamma-synthase activity
EA652_RS04465	COG1530	ribonuclease E activity
EA652_RS04470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EA652_RS04485	COG1121	(ABC) transporter
EA652_RS04490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EA652_RS04500	COG2801	Transposase and inactivated derivatives
EA652_RS04515	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EA652_RS04520	COG0670	Belongs to the BI1 family
EA652_RS04525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EA652_RS04535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EA652_RS04560	COG0531	amino acid
EA652_RS04575	COG0527	aspartate kinase activity
EA652_RS04620	COG0839	Belongs to the complex I subunit 6 family
EA652_RS04625	COG0713	ATP synthesis coupled electron transport
EA652_RS04630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EA652_RS04635	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EA652_RS04640	COG1007	ATP synthesis coupled electron transport
EA652_RS04645	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EA652_RS04645	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EA652_RS04680	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EA652_RS04685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EA652_RS04700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EA652_RS04715	COG0492	ferredoxin-NADP+ reductase activity
EA652_RS04725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EA652_RS04735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EA652_RS04740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EA652_RS04745	COG1127	ABC transporter
EA652_RS04775	COG3344	reverse transcriptase
EA652_RS04785	COG1104	cysteine desulfurase activity
EA652_RS04790	COG0312	modulator of DNA gyrase
EA652_RS04820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EA652_RS04820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EA652_RS04825	COG2801	Transposase and inactivated derivatives
EA652_RS04860	COG0006	proline dipeptidase activity
EA652_RS04895	COG4695	Portal protein
EA652_RS04910	COG0321	lipoyl(octanoyl) transferase activity
EA652_RS04930	COG0047	phosphoribosylformylglycinamidine synthase activity
EA652_RS04960	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EA652_RS04975	COG1253	flavin adenine dinucleotide binding
EA652_RS04985	COG0436	Aminotransferase
EA652_RS05000	COG0372	Belongs to the citrate synthase family
EA652_RS05015	COG4974	Belongs to the 'phage' integrase family
EA652_RS05025	COG0628	permease
EA652_RS05035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EA652_RS05035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EA652_RS05040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EA652_RS05060	COG3344	reverse transcriptase
EA652_RS05195	COG0666	response to abiotic stimulus
EA652_RS05205	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EA652_RS05245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EA652_RS05250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EA652_RS05255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EA652_RS05275	COG1132	(ABC) transporter
EA652_RS05300	COG0697	spore germination
EA652_RS05320	COG2003	Belongs to the UPF0758 family
EA652_RS05325	COG1396	sequence-specific DNA binding
EA652_RS05340	COG3344	reverse transcriptase
EA652_RS05350	COG1178	ABC-type Fe3 transport system permease component
EA652_RS05355	COG1054	Belongs to the UPF0176 family
EA652_RS05360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EA652_RS05410	COG0477	Major facilitator Superfamily
EA652_RS05440	COG1230	cation diffusion facilitator family transporter
EA652_RS05450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EA652_RS05455	COG1115	amino acid carrier protein
EA652_RS05460	COG1115	amino acid carrier protein
EA652_RS05465	COG1183	phosphatidylcholine synthase activity
EA652_RS05490	COG0484	heat shock protein binding
EA652_RS05495	COG0285	dihydrofolate synthase activity
EA652_RS05510	COG2867	negative regulation of translational initiation
EA652_RS05515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EA652_RS05545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EA652_RS05550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EA652_RS05560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EA652_RS05590	COG2857	Cytochrome c1
EA652_RS05590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EA652_RS05595	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EA652_RS05610	COG0484	heat shock protein binding
EA652_RS05635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EA652_RS05645	COG0493	'glutamate synthase
EA652_RS05645	COG0543	2 iron, 2 sulfur cluster binding
EA652_RS05665	COG0750	zinc metalloprotease
EA652_RS05680	COG0776	regulation of translation
EA652_RS05685	COG0539	negative regulation of cytoplasmic translation
EA652_RS05690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EA652_RS05705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EA652_RS05720	COG0259	pyridoxamine-phosphate oxidase activity
EA652_RS05730	COG2333	competence protein COMEC
EA652_RS05730	COG0658	competence protein
EA652_RS05740	COG0564	pseudouridine synthase activity
EA652_RS05770	COG2070	2-Nitropropane dioxygenase
EA652_RS05785	COG3451	type IV secretory pathway VirB4
EA652_RS05805	COG0508	dehydrogenase complex catalyzes the overall conversion of
EA652_RS05820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EA652_RS05860	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EA652_RS05875	COG0142	geranyltranstransferase activity
EA652_RS05880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EA652_RS05885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EA652_RS05910	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
EA652_RS05935	COG0723	plastoquinol--plastocyanin reductase activity
EA652_RS05960	COG1268	BioY protein
EA652_RS05965	COG0778	Nitroreductase
EA652_RS05995	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EA652_RS06025	COG1475	DNA binding
EA652_RS06040	COG2009	succinate dehydrogenase
EA652_RS06045	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EA652_RS06060	COG4591	ABC-type transport system involved in lipoprotein release permease component
EA652_RS06080	COG0312	modulator of DNA gyrase
EA652_RS06085	COG1278	Cold shock
EA652_RS06090	COG0513	Belongs to the DEAD box helicase family
EA652_RS06105	COG1830	Aldolase
EA652_RS06115	COG0167	dihydroorotate dehydrogenase activity
EA652_RS06130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EA652_RS06155	COG3346	SURF1 family
EA652_RS06170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EA652_RS06180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EA652_RS06190	COG2885	chlorophyll binding
EA652_RS06220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EA652_RS06230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EA652_RS06235	COG0493	'glutamate synthase
EA652_RS06235	COG0543	2 iron, 2 sulfur cluster binding
EA652_RS06250	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EA652_RS06420	COG1160	GTP binding
EA652_RS06430	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EA652_RS06460	COG0651	ATP synthesis coupled electron transport
EA652_RS06465	COG0772	Belongs to the SEDS family
EA652_RS06470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EA652_RS06475	COG2094	Belongs to the DNA glycosylase MPG family
EA652_RS06520	COG0084	hydrolase, TatD family'
EA652_RS06530	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EA652_RS06565	COG1090	epimerase
EA652_RS06585	COG0326	Molecular chaperone. Has ATPase activity
EA652_RS06600	COG0156	8-amino-7-oxononanoate synthase activity
EA652_RS06625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EA652_RS06630	COG2205	protein histidine kinase activity
EA652_RS06630	COG2202	Pas domain
EA652_RS06635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EA652_RS06640	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EA652_RS06675	COG1295	ribonuclease BN
EA652_RS06680	COG1028	Short-chain dehydrogenase reductase Sdr
EA652_RS06690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EA652_RS06710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EA652_RS06715	COG1006	Multisubunit Na H antiporter MnhC subunit
EA652_RS06725	COG2111	Na H antiporter
EA652_RS06725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EA652_RS06750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EA652_RS06765	COG0567	Dehydrogenase, E1 component
EA652_RS06790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EA652_RS06805	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EA652_RS06810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EA652_RS06815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EA652_RS06825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EA652_RS06835	COG0174	glutamine synthetase