locus-tag	class	description
WD_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WD_RS00035	COG3736	Type IV secretory pathway, component VirB8
WD_RS00050	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WD_RS00055	COG3505	Type IV secretory pathway VirD4
WD_RS00065	COG2890	protein-(glutamine-N5) methyltransferase activity
WD_RS00070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WD_RS00085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WD_RS00100	COG0250	Participates in transcription elongation, termination and antitermination
WD_RS00105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WD_RS00110	COG0081	regulation of translation
WD_RS00115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WD_RS00120	COG0222	ribosome binding
WD_RS00125	COG0085	RNA polymerase activity
WD_RS00125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WD_RS00130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WD_RS00130	COG0085	RNA polymerase activity
WD_RS00135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WD_RS00145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WD_RS00170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WD_RS00175	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WD_RS00180	COG0823	Involved in the tonB-independent uptake of proteins
WD_RS00190	COG0484	heat shock protein binding
WD_RS00255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WD_RS00265	COG0776	regulation of translation
WD_RS00280	COG0495	leucyl-tRNA aminoacylation
WD_RS00300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WD_RS00315	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WD_RS00325	COG3827	peptidoglycan binding
WD_RS00330	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WD_RS00385	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WD_RS00390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WD_RS00405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WD_RS00415	COG0149	triose-phosphate isomerase activity
WD_RS00420	COG0758	DNA mediated transformation
WD_RS00425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WD_RS00440	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WD_RS00445	COG1686	Belongs to the peptidase S11 family
WD_RS00475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WD_RS00490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WD_RS00500	COG0187	DNA topoisomerase II activity
WD_RS00525	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WD_RS00540	COG1674	ftsk spoiiie
WD_RS00580	COG0307	riboflavin synthase, alpha
WD_RS00590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WD_RS00595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WD_RS00600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WD_RS00605	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WD_RS00615	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WD_RS00630	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WD_RS00640	COG1845	cytochrome c oxidase, subunit III
WD_RS00645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WD_RS00650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WD_RS00655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WD_RS00670	COG0215	cysteine-tRNA ligase activity
WD_RS00675	COG3932	Exopolysaccharide synthesis, ExoD
WD_RS00685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WD_RS00690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WD_RS00700	COG0322	excinuclease ABC activity
WD_RS00710	COG0752	glycyl-tRNA synthetase alpha subunit
WD_RS00720	COG0113	porphobilinogen synthase activity
WD_RS00725	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WD_RS00745	COG1573	uracil-dna glycosylase
WD_RS00750	COG0242	peptide deformylase activity
WD_RS00755	COG0849	cell division
WD_RS00760	COG0024	Methionine aminopeptidase
WD_RS00765	COG0477	Major facilitator Superfamily
WD_RS00770	COG0275	rRNA processing
WD_RS00790	COG0193	aminoacyl-tRNA hydrolase activity
WD_RS00800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WD_RS00840	COG0237	dephospho-CoA kinase activity
WD_RS00845	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WD_RS00850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WD_RS00865	COG1253	flavin adenine dinucleotide binding
WD_RS00875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WD_RS00875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WD_RS00900	COG0573	inorganic phosphate transmembrane transporter activity
WD_RS00905	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WD_RS00910	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WD_RS00925	COG0235	Class ii aldolase
WD_RS00970	COG4804	nuclease activity
WD_RS00975	COG1381	Involved in DNA repair and RecF pathway recombination
WD_RS00990	COG2902	Dehydrogenase
WD_RS00995	COG0542	response to heat
WD_RS01005	COG1217	gtp-binding protein TYPA
WD_RS01010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WD_RS01015	COG1823	symporter activity
WD_RS01030	COG1138	Cytochrome C-type biogenesis protein
WD_RS01045	COG3577	Aspartyl protease
WD_RS01085	COG0756	dUTP diphosphatase activity
WD_RS01090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WD_RS01095	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WD_RS01100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WD_RS01105	COG2814	Major facilitator Superfamily
WD_RS01120	COG1322	Protein conserved in bacteria
WD_RS01130	COG3328	transposase activity
WD_RS01150	COG2003	Belongs to the UPF0758 family
WD_RS01170	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WD_RS01325	COG2963	transposase activity
WD_RS01335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WD_RS01340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WD_RS01345	COG0109	protoheme IX farnesyltransferase activity
WD_RS01350	COG0328	RNA-DNA hybrid ribonuclease activity
WD_RS01360	COG0459	protein refolding
WD_RS01365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WD_RS01370	COG0354	folic acid binding
WD_RS01375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WD_RS01385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WD_RS01395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WD_RS01400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WD_RS01405	COG0740	serine-type endopeptidase activity
WD_RS01410	COG0544	peptidyl-prolyl cis-trans isomerase activity
WD_RS01440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WD_RS01480	COG1115	amino acid carrier protein
WD_RS01490	COG0424	maF-like protein
WD_RS01510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WD_RS01525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WD_RS01555	COG2801	Transposase and inactivated derivatives
WD_RS01570	COG0358	DNA primase activity
WD_RS01575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WD_RS01585	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WD_RS01595	COG0305	Participates in initiation and elongation during chromosome replication
WD_RS01605	COG1714	RDD family
WD_RS01610	COG2003	Belongs to the UPF0758 family
WD_RS01620	COG1074	ATP-dependent DNA helicase activity
WD_RS01625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WD_RS01635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WD_RS01655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WD_RS01675	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WD_RS01680	COG2239	Acts as a magnesium transporter
WD_RS01725	COG2814	Major facilitator Superfamily
WD_RS01735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WD_RS01760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WD_RS01765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WD_RS01770	COG2226	methyltransferase
WD_RS01795	COG1132	(ABC) transporter
WD_RS01805	COG0018	arginyl-trna synthetase
WD_RS01825	COG4133	protoheme IX ABC transporter activity
WD_RS01835	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WD_RS01840	COG0477	Major facilitator Superfamily
WD_RS01845	COG0564	pseudouridine synthase activity
WD_RS01850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WD_RS01855	COG1981	membrane
WD_RS01860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WD_RS01870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WD_RS01880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WD_RS01880	COG0072	phenylalanine-tRNA ligase activity
WD_RS01890	COG0356	it plays a direct role in the translocation of protons across the membrane
WD_RS01895	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WD_RS01915	COG1612	heme a metabolic process
WD_RS01920	COG4770	biotin carboxylase activity
WD_RS01930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WD_RS01935	COG1053	succinate dehydrogenase
WD_RS01945	COG0194	GDP metabolic process
WD_RS01960	COG0012	GTP binding
WD_RS01970	COG0617	tRNA 3'-terminal CCA addition
WD_RS01990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WD_RS01995	COG0805	protein transport
WD_RS02000	COG1438	arginine binding
WD_RS02005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WD_RS02010	COG0765	amino acid transport
WD_RS02015	COG1126	abc transporter atp-binding protein
WD_RS02045	COG0284	orotidine-5'-phosphate decarboxylase activity
WD_RS02060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WD_RS02065	COG0525	valine-tRNA ligase activity
WD_RS02085	COG0504	CTP synthase activity
WD_RS02090	COG0590	tRNA wobble adenosine to inosine editing
WD_RS02095	COG0477	Major facilitator Superfamily
WD_RS02105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WD_RS02110	COG0508	dehydrogenase complex catalyzes the overall conversion of
WD_RS02110	COG0022	dehydrogenase e1 component
WD_RS02120	COG0481	GTPase activity
WD_RS02145	COG0739	heme binding
WD_RS02150	COG0217	transcriptional regulatory protein
WD_RS02155	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WD_RS02165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WD_RS02170	COG0280	phosphate acetyltransferase
WD_RS02170	COG0281	malic enzyme
WD_RS02190	COG0114	fumarate hydratase activity
WD_RS02195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WD_RS02200	COG0148	phosphopyruvate hydratase activity
WD_RS02205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WD_RS02230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WD_RS02235	COG0154	amidase activity
WD_RS02255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WD_RS02315	COG2963	transposase activity
WD_RS02335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WD_RS02345	COG0575	Belongs to the CDS family
WD_RS02350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WD_RS02355	COG0233	cytoplasmic translational termination
WD_RS02360	COG0528	UMP kinase activity
WD_RS02365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WD_RS02370	COG0052	Belongs to the universal ribosomal protein uS2 family
WD_RS02380	COG1862	Preprotein translocase
WD_RS02410	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WD_RS02420	COG0508	dehydrogenase complex catalyzes the overall conversion of
WD_RS02445	COG0653	protein targeting
WD_RS02475	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WD_RS02480	COG0163	prenyltransferase activity
WD_RS02485	COG3750	Belongs to the UPF0335 family
WD_RS02490	COG4536	flavin adenine dinucleotide binding
WD_RS02495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WD_RS02500	COG0649	NAD binding
WD_RS02520	COG3621	Patatin-like phospholipase
WD_RS02665	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WD_RS02675	COG0666	response to abiotic stimulus
WD_RS02735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WD_RS02740	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WD_RS02745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WD_RS02765	COG1132	(ABC) transporter
WD_RS02790	COG0697	spore germination
WD_RS02810	COG2003	Belongs to the UPF0758 family
WD_RS02815	COG1396	sequence-specific DNA binding
WD_RS02920	COG2963	transposase activity
WD_RS02925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WD_RS02950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WD_RS02955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WD_RS02960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WD_RS02965	COG0792	nuclease activity
WD_RS02975	COG0202	RNA polymerase activity
WD_RS02980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WD_RS02985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WD_RS02990	COG0563	adenylate kinase activity
WD_RS02995	COG0201	protein transport
WD_RS03005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WD_RS03015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WD_RS03025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WD_RS03050	COG0255	Belongs to the universal ribosomal protein uL29 family
WD_RS03060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WD_RS03075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WD_RS03085	COG0088	Forms part of the polypeptide exit tunnel
WD_RS03090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WD_RS03095	COG0051	transcription antitermination factor activity, RNA binding
WD_RS03100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WD_RS03115	COG0505	Belongs to the CarA family
WD_RS03130	COG1494	fructose-1,6-bisphosphatase
WD_RS03140	COG0574	Belongs to the PEP-utilizing enzyme family
WD_RS03140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WD_RS03150	COG3344	reverse transcriptase
WD_RS03160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WD_RS03175	COG3547	Transposase (IS116 IS110 IS902 family)
WD_RS03180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WD_RS03190	COG1104	cysteine desulfurase activity
WD_RS03195	COG2945	thiolester hydrolase activity
WD_RS03205	COG0316	Belongs to the HesB IscA family
WD_RS03210	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WD_RS03215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WD_RS03215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WD_RS03225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WD_RS03235	COG2171	N-acyltransferase activity
WD_RS03260	COG0768	penicillin binding
WD_RS03270	COG0606	chelatase, subunit chli
WD_RS03295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WD_RS03310	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WD_RS03315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WD_RS03320	COG0745	RESPONSE REGULATOR receiver
WD_RS03330	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WD_RS03335	COG0343	queuine tRNA-ribosyltransferase activity
WD_RS03345	COG0612	Peptidase, M16
WD_RS03350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WD_RS03355	COG1271	oxidase subunit
WD_RS03360	COG1294	oxidase, subunit
WD_RS03365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WD_RS03405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WD_RS03410	COG4974	Belongs to the 'phage' integrase family
WD_RS03425	COG0450	alkyl hydroperoxide reductase
WD_RS03440	COG0196	riboflavin kinase activity
WD_RS03445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WD_RS03450	COG0612	Peptidase, M16
WD_RS03460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WD_RS03485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WD_RS03515	COG0629	single-stranded DNA binding
WD_RS03520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WD_RS03525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WD_RS03530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WD_RS03540	COG0360	Binds together with S18 to 16S ribosomal RNA
WD_RS03550	COG0359	binds to the 23S rRNA
WD_RS03555	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WD_RS03570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WD_RS03575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WD_RS03585	COG0473	3-isopropylmalate dehydrogenase activity
WD_RS03600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WD_RS03620	COG0142	geranyltranstransferase activity
WD_RS03625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WD_RS03640	COG3474	cytochrome
WD_RS03665	COG0442	prolyl-tRNA aminoacylation
WD_RS03670	COG0736	holo-[acyl-carrier-protein] synthase activity
WD_RS03695	COG0009	L-threonylcarbamoyladenylate synthase
WD_RS03705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WD_RS03715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WD_RS03750	COG0330	HflC and HflK could
WD_RS03780	COG0556	nucleotide-excision repair
WD_RS03800	COG3088	subunit of a heme lyase
WD_RS03800	COG4235	cytochrome complex assembly
WD_RS03815	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WD_RS03830	COG0742	ribosomal rna small subunit methyltransferase
WD_RS03845	COG1340	protein secretion by the type IV secretion system
WD_RS03845	COG3704	protein secretion by the type IV secretion system
WD_RS03850	COG3704	protein secretion by the type IV secretion system
WD_RS03855	COG3704	protein secretion by the type IV secretion system
WD_RS03860	COG3451	type IV secretory pathway VirB4
WD_RS03870	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WD_RS03875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WD_RS03890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WD_RS03895	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WD_RS03910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WD_RS03915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WD_RS03920	COG0254	rRNA binding
WD_RS03925	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WD_RS03975	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
WD_RS04000	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WD_RS04005	COG0552	protein localization to endoplasmic reticulum
WD_RS04010	COG0822	iron-sulfur transferase activity
WD_RS04015	COG0316	Belongs to the HesB IscA family
WD_RS04020	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WD_RS04030	COG0681	Belongs to the peptidase S26 family
WD_RS04040	COG1840	ABC-type Fe3 transport system, periplasmic component
WD_RS04075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WD_RS04080	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WD_RS04085	COG1185	polyribonucleotide nucleotidyltransferase activity
WD_RS04125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WD_RS04170	COG0626	cystathionine gamma-synthase activity
WD_RS04180	COG0443	Heat shock 70 kDa protein
WD_RS04185	COG1530	ribonuclease E activity
WD_RS04190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WD_RS04230	COG1121	(ABC) transporter
WD_RS04235	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WD_RS04285	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WD_RS04290	COG0670	Belongs to the BI1 family
WD_RS04295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WD_RS04305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WD_RS04320	COG0531	amino acid
WD_RS04330	COG0527	aspartate kinase activity
WD_RS04355	COG0839	Belongs to the complex I subunit 6 family
WD_RS04360	COG0713	ATP synthesis coupled electron transport
WD_RS04365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WD_RS04370	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WD_RS04375	COG1007	ATP synthesis coupled electron transport
WD_RS04380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WD_RS04380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WD_RS04380	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WD_RS04380	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WD_RS04385	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WD_RS04415	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WD_RS04420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WD_RS04425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WD_RS04435	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WD_RS04440	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WD_RS04450	COG0492	ferredoxin-NADP+ reductase activity
WD_RS04455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WD_RS04460	COG0416	fatty acid biosynthetic process
WD_RS04465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WD_RS04470	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WD_RS04475	COG1127	ABC transporter
WD_RS04485	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WD_RS04495	COG3344	reverse transcriptase
WD_RS04505	COG1104	cysteine desulfurase activity
WD_RS04510	COG0312	modulator of DNA gyrase
WD_RS04540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WD_RS04540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WD_RS04575	COG0445	tRNA wobble uridine modification
WD_RS04595	COG4695	Portal protein
WD_RS04605	COG0321	lipoyl(octanoyl) transferase activity
WD_RS04620	COG0047	phosphoribosylformylglycinamidine synthase activity
WD_RS04640	COG0336	Belongs to the RNA methyltransferase TrmD family
WD_RS04645	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WD_RS04650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WD_RS04665	COG1253	flavin adenine dinucleotide binding
WD_RS04670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WD_RS04675	COG0436	Aminotransferase
WD_RS04700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WD_RS04720	COG1230	cation diffusion facilitator family transporter
WD_RS04730	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WD_RS04735	COG1115	amino acid carrier protein
WD_RS04740	COG1115	amino acid carrier protein
WD_RS04745	COG1183	phosphatidylcholine synthase activity
WD_RS04755	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WD_RS04760	COG0484	heat shock protein binding
WD_RS04765	COG0285	dihydrofolate synthase activity
WD_RS04775	COG2867	negative regulation of translational initiation
WD_RS04805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WD_RS04810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WD_RS04820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WD_RS04835	COG0101	tRNA pseudouridine synthase activity
WD_RS04845	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WD_RS04845	COG2857	Cytochrome c1
WD_RS04850	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WD_RS04865	COG0484	heat shock protein binding
WD_RS04875	COG0124	histidyl-tRNA synthetase
WD_RS04880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WD_RS04885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WD_RS04895	COG0543	2 iron, 2 sulfur cluster binding
WD_RS04895	COG0493	'glutamate synthase
WD_RS04900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WD_RS04915	COG0750	zinc metalloprotease
WD_RS04930	COG0776	regulation of translation
WD_RS04935	COG0539	negative regulation of cytoplasmic translation
WD_RS04940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WD_RS04970	COG1160	GTP binding
WD_RS04980	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
WD_RS04985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WD_RS04990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WD_RS05010	COG0651	ATP synthesis coupled electron transport
WD_RS05015	COG0772	Belongs to the SEDS family
WD_RS05020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WD_RS05025	COG2094	Belongs to the DNA glycosylase MPG family
WD_RS05035	COG2255	four-way junction helicase activity
WD_RS05040	COG0632	four-way junction helicase activity
WD_RS05080	COG0494	nUDIX hydrolase
WD_RS05085	COG0084	hydrolase, TatD family'
WD_RS05095	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WD_RS05105	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WD_RS05130	COG1090	epimerase
WD_RS05145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WD_RS05150	COG1054	Belongs to the UPF0176 family
WD_RS05155	COG1178	ABC-type Fe3 transport system permease component
WD_RS05165	COG3344	reverse transcriptase
WD_RS05180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WD_RS05185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WD_RS05185	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WD_RS05190	COG0628	permease
WD_RS05200	COG4974	Belongs to the 'phage' integrase family
WD_RS05210	COG0268	Binds directly to 16S ribosomal RNA
WD_RS05215	COG0372	Belongs to the citrate synthase family
WD_RS05235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WD_RS05245	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WD_RS05250	COG0259	pyridoxamine-phosphate oxidase activity
WD_RS05260	COG2333	competence protein COMEC
WD_RS05260	COG0658	competence protein
WD_RS05270	COG0564	pseudouridine synthase activity
WD_RS05295	COG0126	phosphoglycerate kinase activity
WD_RS05305	COG2070	2-Nitropropane dioxygenase
WD_RS05320	COG3451	type IV secretory pathway VirB4
WD_RS05340	COG0508	dehydrogenase complex catalyzes the overall conversion of
WD_RS05355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WD_RS05360	COG0105	UTP biosynthetic process
WD_RS05370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WD_RS05390	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WD_RS05405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WD_RS05410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WD_RS05420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WD_RS05425	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
WD_RS05440	COG0723	plastoquinol--plastocyanin reductase activity
WD_RS05465	COG1268	BioY protein
WD_RS05470	COG0778	Nitroreductase
WD_RS05480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WD_RS05485	COG0045	succinate-CoA ligase (ADP-forming) activity
WD_RS05500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WD_RS05530	COG1475	DNA binding
WD_RS05545	COG2009	succinate dehydrogenase
WD_RS05580	COG4591	ABC-type transport system involved in lipoprotein release permease component
WD_RS05595	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WD_RS05600	COG0312	modulator of DNA gyrase
WD_RS05605	COG1278	Cold shock
WD_RS05610	COG0513	Belongs to the DEAD box helicase family
WD_RS05620	COG1830	Aldolase
WD_RS05630	COG0167	dihydroorotate dehydrogenase activity
WD_RS05645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WD_RS05685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WD_RS05695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WD_RS05700	COG0037	tRNA processing
WD_RS05705	COG2885	chlorophyll binding
WD_RS05720	COG0482	sulfurtransferase activity
WD_RS05730	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WD_RS05740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WD_RS05745	COG0493	'glutamate synthase
WD_RS05745	COG0543	2 iron, 2 sulfur cluster binding
WD_RS05760	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WD_RS05775	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WD_RS05780	COG0326	Molecular chaperone. Has ATPase activity
WD_RS05790	COG0156	8-amino-7-oxononanoate synthase activity
WD_RS05800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WD_RS05810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WD_RS05815	COG2202	Pas domain
WD_RS05815	COG2205	protein histidine kinase activity
WD_RS05820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WD_RS05825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WD_RS05845	COG1295	ribonuclease BN
WD_RS05850	COG1028	Short-chain dehydrogenase reductase Sdr
WD_RS05860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WD_RS05875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WD_RS05880	COG1006	Multisubunit Na H antiporter MnhC subunit
WD_RS05890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WD_RS05890	COG2111	Na H antiporter
WD_RS05915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WD_RS05925	COG0567	Dehydrogenase, E1 component
WD_RS05950	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WD_RS05955	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WD_RS05960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WD_RS05965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WD_RS05975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WD_RS05985	COG0174	glutamine synthetase
WD_RS06140	COG0142	geranyltranstransferase activity