locus-tag	class	description
WwAu_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WwAu_RS00025	COG3736	Type IV secretory pathway, component VirB8
WwAu_RS00040	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WwAu_RS00045	COG3505	Type IV secretory pathway VirD4
WwAu_RS00055	COG2890	protein-(glutamine-N5) methyltransferase activity
WwAu_RS00065	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WwAu_RS00080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WwAu_RS00095	COG0250	Participates in transcription elongation, termination and antitermination
WwAu_RS00100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WwAu_RS00105	COG0081	regulation of translation
WwAu_RS00110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WwAu_RS00115	COG0222	ribosome binding
WwAu_RS00120	COG0085	RNA polymerase activity
WwAu_RS00120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WwAu_RS00125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WwAu_RS00135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WwAu_RS00155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WwAu_RS00160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WwAu_RS00165	COG0823	Involved in the tonB-independent uptake of proteins
WwAu_RS00225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WwAu_RS00235	COG0776	regulation of translation
WwAu_RS00250	COG0495	leucyl-tRNA aminoacylation
WwAu_RS00260	COG2801	Transposase and inactivated derivatives
WwAu_RS00265	COG2801	Transposase and inactivated derivatives
WwAu_RS00290	COG0489	protein tyrosine kinase activity
WwAu_RS00300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WwAu_RS00310	COG0193	aminoacyl-tRNA hydrolase activity
WwAu_RS00330	COG0275	rRNA processing
WwAu_RS00335	COG0477	Major facilitator Superfamily
WwAu_RS00340	COG0024	Methionine aminopeptidase
WwAu_RS00345	COG0849	cell division
WwAu_RS00350	COG0242	peptide deformylase activity
WwAu_RS00355	COG1573	uracil-dna glycosylase
WwAu_RS00375	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WwAu_RS00380	COG0113	porphobilinogen synthase activity
WwAu_RS00390	COG0752	glycyl-tRNA synthetase alpha subunit
WwAu_RS00400	COG0322	excinuclease ABC activity
WwAu_RS00410	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WwAu_RS00415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WwAu_RS00425	COG3932	Exopolysaccharide synthesis, ExoD
WwAu_RS00430	COG0215	cysteine-tRNA ligase activity
WwAu_RS00445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WwAu_RS00455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WwAu_RS00465	COG1845	cytochrome c oxidase, subunit III
WwAu_RS00475	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WwAu_RS00485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WwAu_RS00495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WwAu_RS00500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WwAu_RS00505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WwAu_RS00510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WwAu_RS00520	COG0307	riboflavin synthase, alpha
WwAu_RS00575	COG1674	ftsk spoiiie
WwAu_RS00590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WwAu_RS00605	COG2801	Transposase and inactivated derivatives
WwAu_RS00625	COG0187	DNA topoisomerase II activity
WwAu_RS00640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WwAu_RS00655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WwAu_RS00680	COG1686	Belongs to the peptidase S11 family
WwAu_RS00685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WwAu_RS00700	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WwAu_RS00710	COG0149	triose-phosphate isomerase activity
WwAu_RS00720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WwAu_RS00745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WwAu_RS00750	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WwAu_RS00775	COG2801	Transposase and inactivated derivatives
WwAu_RS00780	COG2801	Transposase and inactivated derivatives
WwAu_RS00815	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WwAu_RS00820	COG3827	peptidoglycan binding
WwAu_RS00845	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WwAu_RS00860	COG2801	Transposase and inactivated derivatives
WwAu_RS00865	COG2801	Transposase and inactivated derivatives
WwAu_RS00880	COG0237	dephospho-CoA kinase activity
WwAu_RS00885	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WwAu_RS00890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WwAu_RS00905	COG1253	flavin adenine dinucleotide binding
WwAu_RS00915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WwAu_RS00915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WwAu_RS00950	COG0573	inorganic phosphate transmembrane transporter activity
WwAu_RS00955	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WwAu_RS00960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WwAu_RS00990	COG2814	Major facilitator Superfamily
WwAu_RS00995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WwAu_RS01000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WwAu_RS01005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WwAu_RS01010	COG0756	dUTP diphosphatase activity
WwAu_RS01055	COG3577	Aspartyl protease
WwAu_RS01070	COG1138	Cytochrome C-type biogenesis protein
WwAu_RS01085	COG1301	dicarboxylic acid transport
WwAu_RS01090	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WwAu_RS01095	COG1217	gtp-binding protein TYPA
WwAu_RS01110	COG0542	response to heat
WwAu_RS01115	COG2902	Dehydrogenase
WwAu_RS01135	COG1381	Involved in DNA repair and RecF pathway recombination
WwAu_RS01145	COG4804	nuclease activity
WwAu_RS01185	COG0235	Class ii aldolase
WwAu_RS01205	COG1322	Protein conserved in bacteria
WwAu_RS01225	COG0649	NAD binding
WwAu_RS01230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WwAu_RS01235	COG4536	flavin adenine dinucleotide binding
WwAu_RS01240	COG3750	Belongs to the UPF0335 family
WwAu_RS01245	COG0163	prenyltransferase activity
WwAu_RS01250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WwAu_RS01260	COG2801	Transposase and inactivated derivatives
WwAu_RS01305	COG1396	sequence-specific DNA binding
WwAu_RS01310	COG2003	Belongs to the UPF0758 family
WwAu_RS01335	COG0697	spore germination
WwAu_RS01350	COG3621	Patatin-like phospholipase
WwAu_RS01355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WwAu_RS01490	COG0666	response to abiotic stimulus
WwAu_RS01635	COG2801	Transposase and inactivated derivatives
WwAu_RS01640	COG2801	Transposase and inactivated derivatives
WwAu_RS01645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WwAu_RS01650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WwAu_RS01655	COG0109	protoheme IX farnesyltransferase activity
WwAu_RS01660	COG0328	RNA-DNA hybrid ribonuclease activity
WwAu_RS01670	COG0459	protein refolding
WwAu_RS01675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WwAu_RS01680	COG0354	folic acid binding
WwAu_RS01685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WwAu_RS01700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WwAu_RS01710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WwAu_RS01715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WwAu_RS01725	COG0544	peptidyl-prolyl cis-trans isomerase activity
WwAu_RS01755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WwAu_RS01835	COG1115	amino acid carrier protein
WwAu_RS01850	COG0424	maF-like protein
WwAu_RS01870	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WwAu_RS01885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WwAu_RS01915	COG2801	Transposase and inactivated derivatives
WwAu_RS01920	COG2801	Transposase and inactivated derivatives
WwAu_RS01935	COG0358	DNA primase activity
WwAu_RS01945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WwAu_RS01955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WwAu_RS01965	COG0305	Participates in initiation and elongation during chromosome replication
WwAu_RS01975	COG1714	RDD family
WwAu_RS01980	COG2003	Belongs to the UPF0758 family
WwAu_RS01990	COG1074	ATP-dependent DNA helicase activity
WwAu_RS01995	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WwAu_RS02005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WwAu_RS02025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WwAu_RS02045	COG2801	Transposase and inactivated derivatives
WwAu_RS02050	COG2801	Transposase and inactivated derivatives
WwAu_RS02060	COG2239	Acts as a magnesium transporter
WwAu_RS02065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WwAu_RS02100	COG2814	Major facilitator Superfamily
WwAu_RS02125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WwAu_RS02150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WwAu_RS02155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WwAu_RS02160	COG2226	methyltransferase
WwAu_RS02195	COG1132	(ABC) transporter
WwAu_RS02205	COG0018	arginyl-trna synthetase
WwAu_RS02235	COG4133	protoheme IX ABC transporter activity
WwAu_RS02250	COG0477	Major facilitator Superfamily
WwAu_RS02255	COG0564	pseudouridine synthase activity
WwAu_RS02260	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WwAu_RS02265	COG1981	membrane
WwAu_RS02275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WwAu_RS02285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WwAu_RS02295	COG0072	phenylalanine-tRNA ligase activity
WwAu_RS02295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WwAu_RS02305	COG0356	it plays a direct role in the translocation of protons across the membrane
WwAu_RS02310	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WwAu_RS02330	COG1612	heme a metabolic process
WwAu_RS02335	COG4770	biotin carboxylase activity
WwAu_RS02345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WwAu_RS02350	COG1053	succinate dehydrogenase
WwAu_RS02360	COG0194	GDP metabolic process
WwAu_RS02380	COG0012	GTP binding
WwAu_RS02390	COG0617	tRNA 3'-terminal CCA addition
WwAu_RS02410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WwAu_RS02415	COG0805	protein transport
WwAu_RS02420	COG1438	arginine binding
WwAu_RS02425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WwAu_RS02430	COG0765	amino acid transport
WwAu_RS02435	COG1126	abc transporter atp-binding protein
WwAu_RS02455	COG0284	orotidine-5'-phosphate decarboxylase activity
WwAu_RS02465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WwAu_RS02480	COG0525	valine-tRNA ligase activity
WwAu_RS02500	COG0504	CTP synthase activity
WwAu_RS02505	COG0590	tRNA wobble adenosine to inosine editing
WwAu_RS02510	COG0477	Major facilitator Superfamily
WwAu_RS02525	COG0022	dehydrogenase e1 component
WwAu_RS02525	COG0508	dehydrogenase complex catalyzes the overall conversion of
WwAu_RS02535	COG0481	GTPase activity
WwAu_RS02560	COG0739	heme binding
WwAu_RS02565	COG0217	transcriptional regulatory protein
WwAu_RS02570	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WwAu_RS02580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WwAu_RS02585	COG0280	phosphate acetyltransferase
WwAu_RS02585	COG0281	malic enzyme
WwAu_RS02605	COG0114	fumarate hydratase activity
WwAu_RS02615	COG0148	phosphopyruvate hydratase activity
WwAu_RS02620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WwAu_RS02645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WwAu_RS02650	COG0154	amidase activity
WwAu_RS02675	COG2801	Transposase and inactivated derivatives
WwAu_RS02700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WwAu_RS02710	COG0575	Belongs to the CDS family
WwAu_RS02715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WwAu_RS02730	COG0233	cytoplasmic translational termination
WwAu_RS02735	COG0528	UMP kinase activity
WwAu_RS02740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WwAu_RS02745	COG0052	Belongs to the universal ribosomal protein uS2 family
WwAu_RS02755	COG1862	Preprotein translocase
WwAu_RS02790	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WwAu_RS02800	COG0508	dehydrogenase complex catalyzes the overall conversion of
WwAu_RS02820	COG0653	protein targeting
WwAu_RS02840	COG2801	Transposase and inactivated derivatives
WwAu_RS02855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WwAu_RS02880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WwAu_RS02885	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WwAu_RS02890	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WwAu_RS02895	COG0792	nuclease activity
WwAu_RS02905	COG0202	RNA polymerase activity
WwAu_RS02910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WwAu_RS02915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WwAu_RS02925	COG0201	protein transport
WwAu_RS02935	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WwAu_RS02945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WwAu_RS02955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WwAu_RS02990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WwAu_RS03005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WwAu_RS03020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WwAu_RS03030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WwAu_RS03045	COG0505	Belongs to the CarA family
WwAu_RS03085	COG1494	fructose-1,6-bisphosphatase
WwAu_RS03095	COG0574	Belongs to the PEP-utilizing enzyme family
WwAu_RS03095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WwAu_RS03285	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WwAu_RS03310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WwAu_RS03315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WwAu_RS03320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WwAu_RS03340	COG1132	(ABC) transporter
WwAu_RS03365	COG0697	spore germination
WwAu_RS03390	COG2003	Belongs to the UPF0758 family
WwAu_RS03395	COG1396	sequence-specific DNA binding
WwAu_RS03425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WwAu_RS03445	COG3547	Transposase (IS116 IS110 IS902 family)
WwAu_RS03450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WwAu_RS03465	COG1104	cysteine desulfurase activity
WwAu_RS03470	COG2945	thiolester hydrolase activity
WwAu_RS03485	COG0316	Belongs to the HesB IscA family
WwAu_RS03490	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WwAu_RS03495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WwAu_RS03495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WwAu_RS03505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WwAu_RS03515	COG2171	N-acyltransferase activity
WwAu_RS03540	COG0768	penicillin binding
WwAu_RS03550	COG0606	chelatase, subunit chli
WwAu_RS03580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WwAu_RS03595	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WwAu_RS03600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WwAu_RS03605	COG0745	RESPONSE REGULATOR receiver
WwAu_RS03620	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WwAu_RS03625	COG0343	queuine tRNA-ribosyltransferase activity
WwAu_RS03635	COG0612	Peptidase, M16
WwAu_RS03640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WwAu_RS03645	COG1271	oxidase subunit
WwAu_RS03650	COG1294	oxidase, subunit
WwAu_RS03655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WwAu_RS03695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WwAu_RS03700	COG4974	Belongs to the 'phage' integrase family
WwAu_RS03715	COG0450	alkyl hydroperoxide reductase
WwAu_RS03730	COG0196	riboflavin kinase activity
WwAu_RS03735	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WwAu_RS03740	COG0612	Peptidase, M16
WwAu_RS03750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WwAu_RS03775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WwAu_RS03805	COG0629	single-stranded DNA binding
WwAu_RS03810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WwAu_RS03815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WwAu_RS03820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WwAu_RS03830	COG0360	Binds together with S18 to 16S ribosomal RNA
WwAu_RS03840	COG0359	binds to the 23S rRNA
WwAu_RS03850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WwAu_RS03865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WwAu_RS03870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WwAu_RS03880	COG0473	3-isopropylmalate dehydrogenase activity
WwAu_RS03895	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WwAu_RS03915	COG0142	geranyltranstransferase activity
WwAu_RS03920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WwAu_RS03935	COG3474	cytochrome
WwAu_RS03965	COG0442	prolyl-tRNA aminoacylation
WwAu_RS03970	COG0736	holo-[acyl-carrier-protein] synthase activity
WwAu_RS04000	COG0009	L-threonylcarbamoyladenylate synthase
WwAu_RS04010	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WwAu_RS04020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WwAu_RS04070	COG0330	HflC and HflK could
WwAu_RS04100	COG0556	nucleotide-excision repair
WwAu_RS04120	COG3088	subunit of a heme lyase
WwAu_RS04120	COG4235	cytochrome complex assembly
WwAu_RS04140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WwAu_RS04155	COG0742	ribosomal rna small subunit methyltransferase
WwAu_RS04170	COG1340	protein secretion by the type IV secretion system
WwAu_RS04170	COG3704	protein secretion by the type IV secretion system
WwAu_RS04175	COG3704	protein secretion by the type IV secretion system
WwAu_RS04180	COG3704	protein secretion by the type IV secretion system
WwAu_RS04185	COG3451	type IV secretory pathway VirB4
WwAu_RS04195	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WwAu_RS04210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WwAu_RS04230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WwAu_RS04245	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WwAu_RS04250	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WwAu_RS04255	COG0254	rRNA binding
WwAu_RS04260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WwAu_RS04280	COG2801	Transposase and inactivated derivatives
WwAu_RS04320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WwAu_RS04340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WwAu_RS04345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WwAu_RS04365	COG0651	ATP synthesis coupled electron transport
WwAu_RS04370	COG0772	Belongs to the SEDS family
WwAu_RS04375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WwAu_RS04380	COG2094	Belongs to the DNA glycosylase MPG family
WwAu_RS04390	COG2255	four-way junction helicase activity
WwAu_RS04395	COG0632	four-way junction helicase activity
WwAu_RS04440	COG0084	hydrolase, TatD family'
WwAu_RS04450	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwAu_RS04460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwAu_RS04485	COG1090	epimerase
WwAu_RS04500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WwAu_RS04505	COG1054	Belongs to the UPF0176 family
WwAu_RS04510	COG1178	ABC-type Fe3 transport system permease component
WwAu_RS04535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WwAu_RS04545	COG1127	ABC transporter
WwAu_RS04550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WwAu_RS04555	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WwAu_RS04565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WwAu_RS04575	COG0492	ferredoxin-NADP+ reductase activity
WwAu_RS04585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WwAu_RS04590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwAu_RS04600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WwAu_RS04605	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WwAu_RS04610	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WwAu_RS04640	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WwAu_RS04650	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WwAu_RS04650	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WwAu_RS04650	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WwAu_RS04650	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WwAu_RS04655	COG1007	ATP synthesis coupled electron transport
WwAu_RS04660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwAu_RS04665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WwAu_RS04670	COG0713	ATP synthesis coupled electron transport
WwAu_RS04675	COG0839	Belongs to the complex I subunit 6 family
WwAu_RS04705	COG0527	aspartate kinase activity
WwAu_RS04720	COG0531	amino acid
WwAu_RS04740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WwAu_RS04750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WwAu_RS04755	COG0670	Belongs to the BI1 family
WwAu_RS04760	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WwAu_RS04805	COG1840	ABC-type Fe3 transport system, periplasmic component
WwAu_RS04815	COG0681	Belongs to the peptidase S26 family
WwAu_RS04820	COG0443	Heat shock 70 kDa protein
WwAu_RS04825	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WwAu_RS04830	COG0316	Belongs to the HesB IscA family
WwAu_RS04835	COG0822	iron-sulfur transferase activity
WwAu_RS04840	COG0552	protein localization to endoplasmic reticulum
WwAu_RS04845	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WwAu_RS04860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WwAu_RS04860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WwAu_RS04870	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
WwAu_RS04910	COG1185	polyribonucleotide nucleotidyltransferase activity
WwAu_RS04920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WwAu_RS04970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WwAu_RS04975	COG1121	(ABC) transporter
WwAu_RS05000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WwAu_RS05015	COG0101	tRNA pseudouridine synthase activity
WwAu_RS05025	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WwAu_RS05025	COG2857	Cytochrome c1
WwAu_RS05035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WwAu_RS05050	COG0484	heat shock protein binding
WwAu_RS05060	COG0124	histidyl-tRNA synthetase
WwAu_RS05070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WwAu_RS05080	COG0493	'glutamate synthase
WwAu_RS05080	COG0543	2 iron, 2 sulfur cluster binding
WwAu_RS05085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WwAu_RS05100	COG0750	zinc metalloprotease
WwAu_RS05115	COG0776	regulation of translation
WwAu_RS05120	COG0539	negative regulation of cytoplasmic translation
WwAu_RS05125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WwAu_RS05150	COG1160	GTP binding
WwAu_RS05160	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
WwAu_RS05190	COG0626	cystathionine gamma-synthase activity
WwAu_RS05200	COG0443	Heat shock 70 kDa protein
WwAu_RS05205	COG1530	ribonuclease E activity
WwAu_RS05210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WwAu_RS05230	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WwAu_RS05235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WwAu_RS05270	COG2867	negative regulation of translational initiation
WwAu_RS05285	COG0285	dihydrofolate synthase activity
WwAu_RS05290	COG0484	heat shock protein binding
WwAu_RS05295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WwAu_RS05305	COG1183	phosphatidylcholine synthase activity
WwAu_RS05310	COG1115	amino acid carrier protein
WwAu_RS05315	COG1115	amino acid carrier protein
WwAu_RS05320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WwAu_RS05330	COG1230	cation diffusion facilitator family transporter
WwAu_RS05360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WwAu_RS05390	COG0436	Aminotransferase
WwAu_RS05395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WwAu_RS05400	COG1253	flavin adenine dinucleotide binding
WwAu_RS05415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WwAu_RS05420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WwAu_RS05440	COG0047	phosphoribosylformylglycinamidine synthase activity
WwAu_RS05455	COG0321	lipoyl(octanoyl) transferase activity
WwAu_RS05470	COG4695	Portal protein
WwAu_RS05490	COG0445	tRNA wobble uridine modification
WwAu_RS05525	COG2801	Transposase and inactivated derivatives
WwAu_RS05530	COG2801	Transposase and inactivated derivatives
WwAu_RS05535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WwAu_RS05535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WwAu_RS05565	COG0312	modulator of DNA gyrase
WwAu_RS05575	COG1104	cysteine desulfurase activity
WwAu_RS05605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WwAu_RS05610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WwAu_RS05610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WwAu_RS05615	COG0628	permease
WwAu_RS05630	COG4974	Belongs to the 'phage' integrase family
WwAu_RS05640	COG0268	Binds directly to 16S ribosomal RNA
WwAu_RS05645	COG0372	Belongs to the citrate synthase family
WwAu_RS05665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WwAu_RS05680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WwAu_RS05685	COG0259	pyridoxamine-phosphate oxidase activity
WwAu_RS05695	COG0658	competence protein
WwAu_RS05695	COG2333	competence protein COMEC
WwAu_RS05705	COG0564	pseudouridine synthase activity
WwAu_RS05720	COG0126	phosphoglycerate kinase activity
WwAu_RS05730	COG2070	2-Nitropropane dioxygenase
WwAu_RS05745	COG3451	type IV secretory pathway VirB4
WwAu_RS05765	COG0508	dehydrogenase complex catalyzes the overall conversion of
WwAu_RS05780	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WwAu_RS05790	COG0105	UTP biosynthetic process
WwAu_RS05800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WwAu_RS05820	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WwAu_RS05830	COG0142	geranyltranstransferase activity
WwAu_RS05835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WwAu_RS05840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WwAu_RS05855	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
WwAu_RS05870	COG0723	plastoquinol--plastocyanin reductase activity
WwAu_RS05905	COG1268	BioY protein
WwAu_RS05910	COG0778	Nitroreductase
WwAu_RS05920	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WwAu_RS05925	COG0045	succinate-CoA ligase (ADP-forming) activity
WwAu_RS05940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WwAu_RS05970	COG1475	DNA binding
WwAu_RS05990	COG2009	succinate dehydrogenase
WwAu_RS05995	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WwAu_RS06025	COG4591	ABC-type transport system involved in lipoprotein release permease component
WwAu_RS06040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WwAu_RS06045	COG0312	modulator of DNA gyrase
WwAu_RS06050	COG1278	Cold shock
WwAu_RS06055	COG0513	Belongs to the DEAD box helicase family
WwAu_RS06065	COG1830	Aldolase
WwAu_RS06075	COG0167	dihydroorotate dehydrogenase activity
WwAu_RS06095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WwAu_RS06140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WwAu_RS06150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WwAu_RS06155	COG0037	tRNA processing
WwAu_RS06160	COG2885	chlorophyll binding
WwAu_RS06175	COG0482	sulfurtransferase activity
WwAu_RS06185	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WwAu_RS06195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WwAu_RS06200	COG0493	'glutamate synthase
WwAu_RS06200	COG0543	2 iron, 2 sulfur cluster binding
WwAu_RS06215	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WwAu_RS06230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WwAu_RS06240	COG0326	Molecular chaperone. Has ATPase activity
WwAu_RS06250	COG0156	8-amino-7-oxononanoate synthase activity
WwAu_RS06260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WwAu_RS06270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WwAu_RS06275	COG2202	Pas domain
WwAu_RS06275	COG2205	protein histidine kinase activity
WwAu_RS06280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WwAu_RS06285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WwAu_RS06305	COG1295	ribonuclease BN
WwAu_RS06320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WwAu_RS06340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WwAu_RS06345	COG1006	Multisubunit Na H antiporter MnhC subunit
WwAu_RS06355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WwAu_RS06355	COG2111	Na H antiporter
WwAu_RS06380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WwAu_RS06390	COG0567	Dehydrogenase, E1 component
WwAu_RS06420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WwAu_RS06425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WwAu_RS06430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WwAu_RS06435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WwAu_RS06445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WwAu_RS06455	COG0174	glutamine synthetase
WwAu_RS06590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WwAu_RS06755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family