locus-tag	class	description
WwMa_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WwMa_RS00015	COG3577	Aspartyl protease
WwMa_RS00040	COG0756	dUTP diphosphatase activity
WwMa_RS00070	COG0736	holo-[acyl-carrier-protein] synthase activity
WwMa_RS00090	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WwMa_RS00105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WwMa_RS00130	COG0284	orotidine-5'-phosphate decarboxylase activity
WwMa_RS00145	COG0525	valine-tRNA ligase activity
WwMa_RS00155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WwMa_RS00175	COG4974	Belongs to the 'phage' integrase family
WwMa_RS00180	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WwMa_RS00185	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WwMa_RS00190	COG1981	membrane
WwMa_RS00195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WwMa_RS00200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WwMa_RS00205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WwMa_RS00210	COG0109	protoheme IX farnesyltransferase activity
WwMa_RS00225	COG0215	cysteine-tRNA ligase activity
WwMa_RS00230	COG3932	Exopolysaccharide synthesis, ExoD
WwMa_RS00245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WwMa_RS00250	COG3842	ATPase activity
WwMa_RS00265	COG1494	fructose-1,6-bisphosphatase
WwMa_RS00275	COG0012	GTP binding
WwMa_RS00290	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WwMa_RS00310	COG2816	NAD+ diphosphatase activity
WwMa_RS00320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WwMa_RS00330	COG2814	Major facilitator Superfamily
WwMa_RS00335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WwMa_RS00350	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
WwMa_RS00440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WwMa_RS00450	COG0575	Belongs to the CDS family
WwMa_RS00465	COG0508	dehydrogenase complex catalyzes the overall conversion of
WwMa_RS00490	COG0542	response to heat
WwMa_RS00495	COG2902	Dehydrogenase
WwMa_RS00510	COG1381	Involved in DNA repair and RecF pathway recombination
WwMa_RS00525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WwMa_RS00550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WwMa_RS00555	COG0459	protein refolding
WwMa_RS00565	COG1115	amino acid carrier protein
WwMa_RS00575	COG0424	maF-like protein
WwMa_RS00645	COG0450	alkyl hydroperoxide reductase
WwMa_RS00660	COG1138	Cytochrome C-type biogenesis protein
WwMa_RS00670	COG2003	Belongs to the UPF0758 family
WwMa_RS00675	COG1686	Belongs to the peptidase S11 family
WwMa_RS00680	COG1322	Protein conserved in bacteria
WwMa_RS00700	COG0653	protein targeting
WwMa_RS00705	COG3335	DDE superfamily endonuclease
WwMa_RS00715	COG0758	DNA mediated transformation
WwMa_RS00720	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WwMa_RS00740	COG1181	Belongs to the D-alanine--D-alanine ligase family
WwMa_RS00765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WwMa_RS00785	COG2003	Belongs to the UPF0758 family
WwMa_RS00830	COG3621	Patatin-like phospholipase
WwMa_RS00945	COG2239	Acts as a magnesium transporter
WwMa_RS00965	COG0564	pseudouridine synthase activity
WwMa_RS00975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WwMa_RS00995	COG0805	protein transport
WwMa_RS01020	COG0617	tRNA 3'-terminal CCA addition
WwMa_RS01025	COG1217	gtp-binding protein TYPA
WwMa_RS01030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WwMa_RS01030	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WwMa_RS01045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WwMa_RS01060	COG1074	ATP-dependent DNA helicase activity
WwMa_RS01065	COG3088	subunit of a heme lyase
WwMa_RS01090	COG0358	DNA primase activity
WwMa_RS01095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WwMa_RS01115	COG0235	Class ii aldolase
WwMa_RS01145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WwMa_RS01160	COG1674	ftsk spoiiie
WwMa_RS01190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WwMa_RS01195	COG0148	phosphopyruvate hydratase activity
WwMa_RS01210	COG3346	SURF1 family
WwMa_RS01245	COG0114	fumarate hydratase activity
WwMa_RS01260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WwMa_RS01275	COG0484	heat shock protein binding
WwMa_RS01285	COG0823	Involved in the tonB-independent uptake of proteins
WwMa_RS01290	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WwMa_RS01295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WwMa_RS01300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WwMa_RS01305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WwMa_RS01325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WwMa_RS01330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WwMa_RS01340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WwMa_RS01375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WwMa_RS01400	COG0508	dehydrogenase complex catalyzes the overall conversion of
WwMa_RS01400	COG0022	dehydrogenase e1 component
WwMa_RS01410	COG0681	Belongs to the peptidase S26 family
WwMa_RS01415	COG0443	Heat shock 70 kDa protein
WwMa_RS01425	COG0316	Belongs to the HesB IscA family
WwMa_RS01430	COG0822	iron-sulfur transferase activity
WwMa_RS01435	COG0552	protein localization to endoplasmic reticulum
WwMa_RS01440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WwMa_RS01445	COG0477	Major facilitator Superfamily
WwMa_RS01455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WwMa_RS01470	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
WwMa_RS01485	COG3736	Type IV secretory pathway, component VirB8
WwMa_RS01510	COG3344	reverse transcriptase
WwMa_RS01525	COG4974	Belongs to the 'phage' integrase family
WwMa_RS01535	COG0268	Binds directly to 16S ribosomal RNA
WwMa_RS01540	COG0372	Belongs to the citrate synthase family
WwMa_RS01555	COG2827	Endonuclease containing a URI domain
WwMa_RS01575	COG2255	four-way junction helicase activity
WwMa_RS01580	COG0632	four-way junction helicase activity
WwMa_RS01585	COG3474	cytochrome
WwMa_RS01605	COG0839	Belongs to the complex I subunit 6 family
WwMa_RS01610	COG0713	ATP synthesis coupled electron transport
WwMa_RS01615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WwMa_RS01620	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwMa_RS01625	COG1007	ATP synthesis coupled electron transport
WwMa_RS01630	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WwMa_RS01630	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WwMa_RS01635	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WwMa_RS01660	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
WwMa_RS01665	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WwMa_RS01670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WwMa_RS01680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwMa_RS01695	COG0492	ferredoxin-NADP+ reductase activity
WwMa_RS01770	COG3344	reverse transcriptase
WwMa_RS01780	COG0489	protein tyrosine kinase activity
WwMa_RS01800	COG0799	negative regulation of ribosome biogenesis
WwMa_RS01805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WwMa_RS01835	COG3344	reverse transcriptase
WwMa_RS01845	COG0717	Belongs to the dCTP deaminase family
WwMa_RS01850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WwMa_RS01865	COG0233	cytoplasmic translational termination
WwMa_RS01870	COG0528	UMP kinase activity
WwMa_RS01875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WwMa_RS01880	COG0052	Belongs to the universal ribosomal protein uS2 family
WwMa_RS01890	COG1862	Preprotein translocase
WwMa_RS01915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WwMa_RS01915	COG4451	ribulose bisphosphate carboxylase, small
WwMa_RS01925	COG0504	CTP synthase activity
WwMa_RS01935	COG0590	tRNA wobble adenosine to inosine editing
WwMa_RS01950	COG4133	protoheme IX ABC transporter activity
WwMa_RS01955	COG0018	arginyl-trna synthetase
WwMa_RS01970	COG1132	(ABC) transporter
WwMa_RS01980	COG2814	Major facilitator Superfamily
WwMa_RS02015	COG0739	heme binding
WwMa_RS02020	COG0217	transcriptional regulatory protein
WwMa_RS02035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WwMa_RS02040	COG0280	phosphate acetyltransferase
WwMa_RS02040	COG0281	malic enzyme
WwMa_RS02050	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WwMa_RS02055	COG1566	PFAM secretion protein HlyD family protein
WwMa_RS02070	COG0574	Belongs to the PEP-utilizing enzyme family
WwMa_RS02070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WwMa_RS02115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WwMa_RS02120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WwMa_RS02125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WwMa_RS02130	COG0792	nuclease activity
WwMa_RS02135	COG0203	ribosomal protein L17
WwMa_RS02140	COG0202	RNA polymerase activity
WwMa_RS02145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WwMa_RS02150	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WwMa_RS02155	COG0563	adenylate kinase activity
WwMa_RS02160	COG0201	protein transport
WwMa_RS02165	COG0200	Binds to the 23S rRNA
WwMa_RS02170	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WwMa_RS02175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WwMa_RS02180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WwMa_RS02185	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WwMa_RS02190	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WwMa_RS02195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WwMa_RS02200	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WwMa_RS02205	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WwMa_RS02215	COG0255	Belongs to the universal ribosomal protein uL29 family
WwMa_RS02220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WwMa_RS02225	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WwMa_RS02230	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WwMa_RS02235	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WwMa_RS02240	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WwMa_RS02250	COG0088	Forms part of the polypeptide exit tunnel
WwMa_RS02255	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WwMa_RS02260	COG0051	transcription antitermination factor activity, RNA binding
WwMa_RS02265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WwMa_RS02300	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WwMa_RS02305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WwMa_RS02310	COG0573	inorganic phosphate transmembrane transporter activity
WwMa_RS02315	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WwMa_RS02345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WwMa_RS02345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WwMa_RS02360	COG1845	cytochrome c oxidase, subunit III
WwMa_RS02370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WwMa_RS02375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
WwMa_RS02385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WwMa_RS02390	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WwMa_RS02405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WwMa_RS02410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WwMa_RS02420	COG0307	riboflavin synthase, alpha
WwMa_RS02430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WwMa_RS02460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WwMa_RS02460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WwMa_RS02465	COG0154	amidase activity
WwMa_RS02470	COG0187	DNA topoisomerase II activity
WwMa_RS02490	COG1183	phosphatidylcholine synthase activity
WwMa_RS02495	COG1115	amino acid carrier protein
WwMa_RS02500	COG1115	amino acid carrier protein
WwMa_RS02505	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WwMa_RS02515	COG1230	cation diffusion facilitator family transporter
WwMa_RS02570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WwMa_RS02580	COG0322	excinuclease ABC activity
WwMa_RS02585	COG0751	glycine-tRNA ligase activity
WwMa_RS02590	COG0752	glycyl-tRNA synthetase alpha subunit
WwMa_RS02600	COG0113	porphobilinogen synthase activity
WwMa_RS02605	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WwMa_RS02610	COG1034	ATP synthesis coupled electron transport
WwMa_RS02620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WwMa_RS02635	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WwMa_RS02640	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WwMa_RS02650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WwMa_RS02660	COG0571	ribonuclease III activity
WwMa_RS02665	COG0167	dihydroorotate dehydrogenase activity
WwMa_RS02680	COG1830	Aldolase
WwMa_RS02690	COG0542	response to heat
WwMa_RS02695	COG0513	Belongs to the DEAD box helicase family
WwMa_RS02700	COG1278	Cold shock
WwMa_RS02705	COG0312	modulator of DNA gyrase
WwMa_RS02710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WwMa_RS02725	COG4591	ABC-type transport system involved in lipoprotein release permease component
WwMa_RS02740	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WwMa_RS02745	COG2009	succinate dehydrogenase
WwMa_RS02770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WwMa_RS02775	COG1006	Multisubunit Na H antiporter MnhC subunit
WwMa_RS02785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WwMa_RS02785	COG2111	Na H antiporter
WwMa_RS02790	COG1320	monovalent cation:proton antiporter activity
WwMa_RS02800	COG1758	RNA polymerase activity
WwMa_RS02810	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WwMa_RS02825	COG0330	HflC and HflK could
WwMa_RS02850	COG0494	nUDIX hydrolase
WwMa_RS02855	COG0084	hydrolase, TatD family'
WwMa_RS02860	COG0039	L-malate dehydrogenase activity
WwMa_RS02865	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwMa_RS02870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwMa_RS02875	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WwMa_RS02880	COG0537	adenosine 5'-monophosphoramidase activity
WwMa_RS02900	COG1090	epimerase
WwMa_RS02910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WwMa_RS02915	COG0416	fatty acid biosynthetic process
WwMa_RS02920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WwMa_RS02925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WwMa_RS02930	COG3842	ATPase activity
WwMa_RS02935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WwMa_RS02945	COG0493	'glutamate synthase
WwMa_RS02945	COG0543	2 iron, 2 sulfur cluster binding
WwMa_RS02965	COG0750	zinc metalloprotease
WwMa_RS02980	COG0776	regulation of translation
WwMa_RS02985	COG0539	negative regulation of cytoplasmic translation
WwMa_RS02990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WwMa_RS03020	COG2094	Belongs to the DNA glycosylase MPG family
WwMa_RS03035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WwMa_RS03055	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WwMa_RS03060	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WwMa_RS03065	COG0336	Belongs to the RNA methyltransferase TrmD family
WwMa_RS03070	COG0335	large ribosomal subunit rRNA binding
WwMa_RS03075	COG0581	inorganic phosphate transmembrane transporter activity
WwMa_RS03080	COG0047	phosphoribosylformylglycinamidine synthase activity
WwMa_RS03090	COG0259	pyridoxamine-phosphate oxidase activity
WwMa_RS03095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WwMa_RS03120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WwMa_RS03150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WwMa_RS03160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WwMa_RS03170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WwMa_RS03175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WwMa_RS03195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WwMa_RS03205	COG2333	competence protein COMEC
WwMa_RS03205	COG0658	competence protein
WwMa_RS03230	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WwMa_RS03235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WwMa_RS03240	COG1028	Short-chain dehydrogenase reductase Sdr
WwMa_RS03245	COG1295	ribonuclease BN
WwMa_RS03260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WwMa_RS03300	COG3344	reverse transcriptase
WwMa_RS03315	COG0156	8-amino-7-oxononanoate synthase activity
WwMa_RS03325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WwMa_RS03330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WwMa_RS03340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WwMa_RS03345	COG2205	protein histidine kinase activity
WwMa_RS03355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WwMa_RS03375	COG0508	dehydrogenase complex catalyzes the overall conversion of
WwMa_RS03390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WwMa_RS03405	COG2885	chlorophyll binding
WwMa_RS03420	COG0482	sulfurtransferase activity
WwMa_RS03430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WwMa_RS03440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WwMa_RS03445	COG0493	'glutamate synthase
WwMa_RS03445	COG0543	2 iron, 2 sulfur cluster binding
WwMa_RS03460	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WwMa_RS03470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WwMa_RS03495	COG0629	single-stranded DNA binding
WwMa_RS03500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WwMa_RS03515	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WwMa_RS03520	COG0670	Belongs to the BI1 family
WwMa_RS03525	COG1104	cysteine desulfurase activity
WwMa_RS03530	COG2945	thiolester hydrolase activity
WwMa_RS03540	COG0316	Belongs to the HesB IscA family
WwMa_RS03545	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WwMa_RS03550	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WwMa_RS03550	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WwMa_RS03560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WwMa_RS03565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WwMa_RS03570	COG1185	polyribonucleotide nucleotidyltransferase activity
WwMa_RS03575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WwMa_RS03590	COG0126	phosphoglycerate kinase activity
WwMa_RS03595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WwMa_RS03610	COG2076	Multidrug Resistance protein
WwMa_RS03615	COG0436	Aminotransferase
WwMa_RS03620	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WwMa_RS03625	COG1253	flavin adenine dinucleotide binding
WwMa_RS03645	COG0651	ATP synthesis coupled electron transport
WwMa_RS03650	COG0772	Belongs to the SEDS family
WwMa_RS03655	COG1104	cysteine desulfurase activity
WwMa_RS03660	COG2003	Belongs to the UPF0758 family
WwMa_RS03705	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
WwMa_RS03710	COG1573	uracil-dna glycosylase
WwMa_RS03715	COG0242	peptide deformylase activity
WwMa_RS03720	COG0849	cell division
WwMa_RS03735	COG0275	rRNA processing
WwMa_RS03745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WwMa_RS03755	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WwMa_RS03760	COG0101	tRNA pseudouridine synthase activity
WwMa_RS03775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WwMa_RS03785	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WwMa_RS03790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WwMa_RS03825	COG2867	negative regulation of translational initiation
WwMa_RS03840	COG0285	dihydrofolate synthase activity
WwMa_RS03865	COG0312	modulator of DNA gyrase
WwMa_RS03880	COG0723	plastoquinol--plastocyanin reductase activity
WwMa_RS03905	COG1268	BioY protein
WwMa_RS03925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WwMa_RS03930	COG0045	succinate-CoA ligase (ADP-forming) activity
WwMa_RS03945	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WwMa_RS03975	COG1475	DNA binding
WwMa_RS03980	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WwMa_RS03980	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WwMa_RS03995	COG0628	permease
WwMa_RS04005	COG3344	reverse transcriptase
WwMa_RS04030	COG0326	Molecular chaperone. Has ATPase activity
WwMa_RS04045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WwMa_RS04070	COG0666	response to abiotic stimulus
WwMa_RS04085	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
WwMa_RS04090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WwMa_RS04100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WwMa_RS04105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WwMa_RS04110	COG0142	geranyltranstransferase activity
WwMa_RS04120	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WwMa_RS04125	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WwMa_RS04140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WwMa_RS04155	COG0105	UTP biosynthetic process
WwMa_RS04160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WwMa_RS04165	COG4536	flavin adenine dinucleotide binding
WwMa_RS04170	COG3750	Belongs to the UPF0335 family
WwMa_RS04175	COG0163	prenyltransferase activity
WwMa_RS04180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WwMa_RS04190	COG0495	leucyl-tRNA aminoacylation
WwMa_RS04205	COG0776	regulation of translation
WwMa_RS04215	COG0556	nucleotide-excision repair
WwMa_RS04220	COG2857	Cytochrome c1
WwMa_RS04220	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WwMa_RS04225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WwMa_RS04255	COG0124	histidyl-tRNA synthetase
WwMa_RS04260	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WwMa_RS04270	COG0531	amino acid
WwMa_RS04285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WwMa_RS04290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WwMa_RS04300	COG1178	ABC-type Fe3 transport system permease component
WwMa_RS04365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WwMa_RS04405	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
WwMa_RS04415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WwMa_RS04415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WwMa_RS04445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WwMa_RS04465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WwMa_RS04470	COG0359	binds to the 23S rRNA
WwMa_RS04480	COG0360	Binds together with S18 to 16S ribosomal RNA
WwMa_RS04500	COG0321	lipoyl(octanoyl) transferase activity
WwMa_RS04545	COG0445	tRNA wobble uridine modification
WwMa_RS04580	COG3451	type IV secretory pathway VirB4
WwMa_RS04595	COG2070	2-Nitropropane dioxygenase
WwMa_RS04610	COG0649	NAD binding
WwMa_RS04615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WwMa_RS04620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WwMa_RS04625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WwMa_RS04635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WwMa_RS04635	COG0072	phenylalanine-tRNA ligase activity
WwMa_RS04645	COG0356	it plays a direct role in the translocation of protons across the membrane
WwMa_RS04650	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WwMa_RS04665	COG1215	transferase activity, transferring glycosyl groups
WwMa_RS04670	COG1612	heme a metabolic process
WwMa_RS04675	COG4770	biotin carboxylase activity
WwMa_RS04685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WwMa_RS04695	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WwMa_RS04710	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WwMa_RS04720	COG3827	peptidoglycan binding
WwMa_RS04725	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WwMa_RS04735	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WwMa_RS04745	COG3451	type IV secretory pathway VirB4
WwMa_RS04750	COG3704	protein secretion by the type IV secretion system
WwMa_RS04755	COG3704	protein secretion by the type IV secretion system
WwMa_RS04775	COG0742	ribosomal rna small subunit methyltransferase
WwMa_RS04780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WwMa_RS04785	COG0612	Peptidase, M16
WwMa_RS04795	COG0343	queuine tRNA-ribosyltransferase activity
WwMa_RS04800	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WwMa_RS04815	COG0745	RESPONSE REGULATOR receiver
WwMa_RS04820	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WwMa_RS04825	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WwMa_RS04840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WwMa_RS04845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WwMa_RS04870	COG0606	chelatase, subunit chli
WwMa_RS04875	COG0726	polysaccharide deacetylase
WwMa_RS04880	COG0768	penicillin binding
WwMa_RS04885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WwMa_RS04890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WwMa_RS04895	COG0740	serine-type endopeptidase activity
WwMa_RS04900	COG0544	peptidyl-prolyl cis-trans isomerase activity
WwMa_RS04925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WwMa_RS04925	COG2890	protein-(glutamine-N5) methyltransferase activity
WwMa_RS04930	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WwMa_RS04935	COG0049	tRNA binding
WwMa_RS04940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WwMa_RS04945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WwMa_RS04960	COG0250	Participates in transcription elongation, termination and antitermination
WwMa_RS04965	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WwMa_RS04970	COG0081	regulation of translation
WwMa_RS04975	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WwMa_RS04980	COG0222	ribosome binding
WwMa_RS04985	COG0085	RNA polymerase activity
WwMa_RS04985	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WwMa_RS04990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WwMa_RS05000	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WwMa_RS05015	COG0473	3-isopropylmalate dehydrogenase activity
WwMa_RS05025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WwMa_RS05040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WwMa_RS05050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WwMa_RS05070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WwMa_RS05085	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WwMa_RS05090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WwMa_RS05095	COG0254	rRNA binding
WwMa_RS05120	COG1840	ABC-type Fe3 transport system, periplasmic component
WwMa_RS05125	COG0540	Belongs to the ATCase OTCase family
WwMa_RS05140	COG0194	GDP metabolic process
WwMa_RS05150	COG1053	succinate dehydrogenase
WwMa_RS05165	COG2171	N-acyltransferase activity
WwMa_RS05195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WwMa_RS05215	COG2003	Belongs to the UPF0758 family
WwMa_RS05230	COG3344	reverse transcriptase
WwMa_RS05250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WwMa_RS05255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WwMa_RS05275	COG1132	(ABC) transporter
WwMa_RS05300	COG0697	spore germination
WwMa_RS05315	COG0149	triose-phosphate isomerase activity
WwMa_RS05325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WwMa_RS05335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WwMa_RS05350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WwMa_RS05355	COG0228	four-way junction DNA binding
WwMa_RS05360	COG0142	geranyltranstransferase activity
WwMa_RS05365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WwMa_RS05380	COG0567	Dehydrogenase, E1 component
WwMa_RS05420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WwMa_RS05435	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WwMa_RS05440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WwMa_RS05460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WwMa_RS05475	COG0612	Peptidase, M16
WwMa_RS05480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WwMa_RS05485	COG0196	riboflavin kinase activity
WwMa_RS05500	COG0481	GTPase activity
WwMa_RS05515	COG1253	flavin adenine dinucleotide binding
WwMa_RS05520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WwMa_RS05520	COG0519	Catalyzes the synthesis of GMP from XMP
WwMa_RS05525	COG1450	Type ii and iii secretion system protein
WwMa_RS05535	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WwMa_RS05540	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WwMa_RS05545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WwMa_RS05550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WwMa_RS05565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WwMa_RS05580	COG3335	DDE superfamily endonuclease
WwMa_RS05585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WwMa_RS05600	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WwMa_RS05610	COG1301	dicarboxylic acid transport
WwMa_RS05615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WwMa_RS05660	COG4804	nuclease activity
WwMa_RS05705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WwMa_RS05710	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WwMa_RS05715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WwMa_RS05725	COG2814	Major facilitator Superfamily
WwMa_RS05750	COG1121	(ABC) transporter
WwMa_RS05755	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WwMa_RS05765	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WwMa_RS05770	COG1530	ribonuclease E activity
WwMa_RS05775	COG0443	Heat shock 70 kDa protein
WwMa_RS05780	COG0271	Belongs to the BolA IbaG family
WwMa_RS05785	COG0626	cystathionine gamma-synthase activity
WwMa_RS05795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WwMa_RS05805	COG0009	L-threonylcarbamoyladenylate synthase
WwMa_RS05810	COG0470	DNA polymerase III
WwMa_RS05830	COG0305	Participates in initiation and elongation during chromosome replication
WwMa_RS05865	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
WwMa_RS05870	COG0237	dephospho-CoA kinase activity
WwMa_RS05900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WwMa_RS05920	COG2801	Transposase and inactivated derivatives
WwMa_RS05955	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WwMa_RS05960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WwMa_RS06210	COG0484	heat shock protein binding
WwMa_RS06225	COG0666	response to abiotic stimulus
WwMa_RS06230	COG0071	Belongs to the small heat shock protein (HSP20) family
WwMa_RS06280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WwMa_RS06285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WwMa_RS06305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)